CN103191460B - Chitosan-silicone dressing as well as preparation method and application thereof - Google Patents

Abstract

The invention discloses chitosan-silicone dressing as well as a preparation method and application thereof. The chitosan-silicone dressing comprises chitosan, silicone, an organosilicone antibacterial agent and matrix. The chitosan silicone dressing is reasonable in formula, convenient to prepare, capable of effectively inhibiting various hyperplastic scars caused by burn injury, trauma, surgery, infection and the like and various wounds caused by protecting burn injury, trauma, surgery, inflection and the like, controlling wound infection, keeping wounds moist and promoting the heating of wounds; and the chitosan silicone dressing has the bacteria inhibition capability being higher than or equal to 99% for Staphylococcus aureus and Escherichia coli.

Description

Chitosan silicone dressing and its preparation method and use

technical field

The invention relates to a medical dressing and its preparation method and application.

Background technique

Clinically, in order to inhibit various hypertrophic scars caused by burns, trauma, surgery, infection, etc. and protect various wounds caused by burns, trauma, surgery, infection, etc., control wound infection, keep the wound moist, and promote wound healing. Various treatment methods and products are often used, but the existing methods and products are often unsatisfactory in therapeutic effect.

Contents of the invention

The object of the present invention is to provide a chitosan silicone dressing with reasonable formula, convenient preparation and good therapeutic effect, as well as its preparation method and application.

Technical solution of the present invention is:

A kind of chitosan silicone dressing is characterized in that: it is made up of the composition of following percentage by weight:

Chitosan 0.1%~5%

Silicone 1~50%

Silicone antibacterial agent 0.5~5%

Substrate margin.

The molecular weight of the silicone is 200-10000, which is methyl silicone oil, ethyl silicone oil, phenyl silicone oil, methyl hydrogen silicone oil or methyl phenyl silicone oil.

The organosilicon antibacterial agent is organosilicon guanidine salt, organosilicon quaternary ammonium salt or flusilazole.

The dosage form of the dressing is an aerosol, and its matrix is composed of ether or petroleum ether and Freon or 134a.

The dosage form of the dressing is a gel, and its matrix component is a mixture of 2-3 components of polyvinyl alcohol, hydroxyethyl cellulose and hydroxymethyl cellulose.

The dosage form of the dressing is a cream, and its base component is composed of the following components by weight:

Glyceryl monostearate 30~60 parts

Stearic acid 80~120 parts

White Vaseline 40~60 parts

Liquid paraffin 130~180 parts

Glycerin 80~120 parts

Tween-80 120~150 parts

Purified water 350~550 parts.

The preparation method of a chitosan silicone dressing is characterized in that the chitosan, silicone and organic antibacterial agent are mixed, dissolved in a substrate, filled in a packaging container, and irradiated to obtain a product.

Application of a chitosan silicone dressing in the preparation of products for inhibiting hypertrophic scars caused by burns, trauma, surgery and infection and protecting various wounds caused by burns, trauma, surgery and infection.

The invention has reasonable formula and convenient preparation, can effectively inhibit various hypertrophic scars caused by burns, trauma, surgery, infection, etc., protect various wounds caused by burns, trauma, surgery, infection, etc., control wound infection, and maintain wound surface Moisturizes and promotes wound healing; verified by more than 100 clinical cases, the effective rate is over 95%; the antibacterial ability of the product against Staphylococcus aureus and Escherichia coli reaches ≥99%.

The present invention will be further described below in conjunction with embodiment.

Detailed ways

Example 1:

A chitosan silicone dressing consists of the following ingredients in percentage by weight:

Chitosan 0.1%~5% (eg 0.1%, 3%, 5%)

Silicone 1~50% (eg 1%, 25%, 50%)

Silicone antibacterial agent 0.5~5% (eg 0.5%, 3%, 5%)

Substrate margin.

The molecular weight of the silicone is 200-10000, which is methyl silicone oil (or ethyl silicone oil or phenyl silicone oil or methyl hydrogen silicone oil or methyl phenyl silicone oil).

The organosilicon antibacterial agent is organosilicon guanidine salt (or organosilicon quaternary ammonium salt or flusilazole).

The dosage form of the dressing is an aerosol, and its matrix is composed of ether (or petroleum ether) and Freon (or 134a); in the matrix components, the mass percentage of ether (or petroleum ether) is 20-80%, and Freon (or 134a ) The mass percentage is 20~80%.

During preparation: mix chitosan, silicone and organic silicon antibacterial agent, dissolve in ether or petroleum ether solvent, fill in aluminum cans, then fill in Freon or 134a, and after irradiation disinfection, the finished product is obtained.

The product is used to inhibit hypertrophic scars caused by burns, trauma, surgery and infection, protect various wounds caused by burns, trauma, surgery and infection, control wound infection, keep wound moist and promote wound healing. When in use, spray on the surface of scars and wounds.

Example 2:

The dosage form of the dressing is a gel, and its matrix component is a mixture of 2 to 3 components of polyvinyl alcohol, hydroxyethyl cellulose, and hydroxymethyl cellulose.

When preparing:

Mix chitosan, silicone and silicone antibacterial agent, dissolve in a matrix made of 2~3 ingredients of polyvinyl alcohol, hydroxyethyl cellulose, and hydroxymethyl cellulose, and fill in In the plastic tube, after irradiation sterilization, it is the finished product. When in use, apply to the surface of scars and wounds.

All the other are with embodiment 1.

Example 3:

The dosage form of the dressing is a cream, and its base composition is composed of the following components by weight:

Glyceryl monostearate 30~60 parts (eg 30 parts, 45 parts, 60 parts)

Stearic acid 80~120 parts (e.g. 80 parts, 100 parts, 120 parts)

White Vaseline 40~60 parts (eg 40 parts, 50 parts, 60 parts)

Liquid paraffin 130~180 parts (eg 130 parts, 150 parts, 180 parts)

Glycerin 80~120 parts (e.g. 80 parts, 100 parts, 120 parts)

Tween-80 120~150 parts (eg 120 parts, 135 parts, 150 parts)

Purified water 350~550 parts (for example 350 parts, 450 parts, 550 parts).

During preparation: mix chitosan, silicone and organic silicon antibacterial agent, miscible in glyceryl monostearate, stearic acid, white petrolatum, liquid paraffin, glycerin, Tween-80, purified water In the matrix, filled in plastic tubes, and sterilized by radiation, it is the finished product. When in use, apply to the surface of scars and wounds.

All the other are with embodiment 1.

Claims (2)

1. a chitosan silicone dressing is characterized in that: it is made up of the composition of following percentage by weight: The molecular weight of the silicone is 200-10000, which is methyl silicone oil, ethyl silicone oil, phenyl silicone oil or methyl hydrogen-containing silicone oil; the silicone antibacterial agent is organosilicon guanidine salt, organosilicon quaternary ammonium salt or fluorosilicon azole; The dosage form of the dressing is a gel, and its matrix component is hydroxyethyl cellulose and/or hydroxymethyl cellulose. 2. the application of a chitosan silicone dressing as claimed in claim 1 in the preparation of various wounds that inhibit burns, trauma, surgery, infection and protect the various wounds caused by burns, trauma, surgery, and infection .