CN103181272A - Artificial planting method for medical raw materials of nothapodytes nimmoniana - Google Patents
Artificial planting method for medical raw materials of nothapodytes nimmoniana Download PDFInfo
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- CN103181272A CN103181272A CN2011104461357A CN201110446135A CN103181272A CN 103181272 A CN103181272 A CN 103181272A CN 2011104461357 A CN2011104461357 A CN 2011104461357A CN 201110446135 A CN201110446135 A CN 201110446135A CN 103181272 A CN103181272 A CN 103181272A
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- Prior art keywords
- planting
- transplanted seedling
- raw material
- nothapodytes
- form nothapodytes
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- 239000002994 raw material Substances 0.000 title claims abstract description 25
- 238000000034 method Methods 0.000 title claims abstract description 16
- 241000060390 Nothapodytes nimmoniana Species 0.000 title abstract 4
- 241000196324 Embryophyta Species 0.000 claims abstract description 19
- 239000000618 nitrogen fertilizer Substances 0.000 claims abstract description 6
- 241000060380 Nothapodytes Species 0.000 claims description 32
- VSJKWCGYPAHWDS-FQEVSTJZSA-N camptothecin Chemical compound C1=CC=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)[C@]5(O)CC)C4=NC2=C1 VSJKWCGYPAHWDS-FQEVSTJZSA-N 0.000 claims description 9
- 230000012010 growth Effects 0.000 claims description 5
- 239000002689 soil Substances 0.000 claims description 5
- 239000000284 extract Substances 0.000 claims description 4
- 210000003608 fece Anatomy 0.000 claims description 4
- 239000010871 livestock manure Substances 0.000 claims description 4
- 235000016709 nutrition Nutrition 0.000 claims description 4
- 230000035764 nutrition Effects 0.000 claims description 4
- 239000003337 fertilizer Substances 0.000 claims description 3
- 235000013399 edible fruits Nutrition 0.000 claims 1
- 235000015097 nutrients Nutrition 0.000 abstract description 2
- 238000011084 recovery Methods 0.000 abstract 2
- 241000208457 Icacinaceae Species 0.000 description 3
- 229940079593 drug Drugs 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- 238000011275 oncology therapy Methods 0.000 description 2
- 238000007634 remodeling Methods 0.000 description 2
- KLWPJMFMVPTNCC-UHFFFAOYSA-N Camptothecin Natural products CCC1(O)C(=O)OCC2=C1C=C3C4Nc5ccccc5C=C4CN3C2=O KLWPJMFMVPTNCC-UHFFFAOYSA-N 0.000 description 1
- 239000008186 active pharmaceutical agent Substances 0.000 description 1
- 229940127093 camptothecin Drugs 0.000 description 1
- VSJKWCGYPAHWDS-UHFFFAOYSA-N dl-camptothecin Natural products C1=CC=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)C5(O)CC)C4=NC2=C1 VSJKWCGYPAHWDS-UHFFFAOYSA-N 0.000 description 1
- 229940088679 drug related substance Drugs 0.000 description 1
- 230000035558 fertility Effects 0.000 description 1
- 239000012467 final product Substances 0.000 description 1
- 230000002015 leaf growth Effects 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Landscapes
- Cultivation Of Plants (AREA)
Abstract
The invention provides an artificial planting method for medical raw materials of nothapodytes nimmoniana, and relates to the field of plant planting, in particular to an artificial planting method for nothapodytes nimmoniana. The method for planting nothapodytes nimmoniana has the advantages that sunlight can be perfectly utilized for generating temperature for plants, the proper temperature and humidity is maintained through regulation, in addition, the nitrogen fertilizer application is combined, transplanted seedlings are prompted to fast grow roots in the early planting period, a great number of nutrients are absorbed, in addition, the transplanted seedlings fast grow towards the semiwoody period, in three to six months, the transplanted seedlings can grow to the state meeting the raw material recovery requirements, the raw material recovery utilization time is shortened, and generally, raw materials can be supplied twice in one year.
Description
Technical field
A kind of artificial method for planting of medicinal raw material form nothapodytes relates to the field of planting of plant, specifically is the artificial method for planting of form nothapodytes, and the camptothecine that form nothapodytes extracts is important cancer therapy drug.
Background technology
Form nothapodytes extensively is distributed in the south of South India, Ceylon, Cambodia and China.The Icacinaceae form nothapodytes is the fine source of camptothecin botanical drug substance, they are as the raw material of cancer therapy drug, and are in great demand, and the content of camptothecine in form nothapodytes is very low, so need a large amount of form nothapodytes of felling to extract camptothecine, as for supply falls short of demand.This way that chops at a tree is sacrificed future gains to satisfy present needs beyond doubt, because the growth of form nothapodytes is unhappy, generally needs 5-8 just can once purchase the process of raw material, and the form nothapodytes of self-sow is not enough, will adopt the manual inseminating.After deliberation, the camptothecine content of each part of form nothapodytes does not wait, and secondly the content maximum of tree root is spray, tender leaf and ripe leaf, and along with the growth of the age of tree, the camptothecine content of each several part can descend.
Summary of the invention
The artificial method for planting of a kind of medicinal raw material form nothapodytes that the present invention proposes its objective is and uses the artificial planting form nothapodytes, repeatedly plucks blade and extracts camptothecine, has increased the supply of form nothapodytes blade, shortens the leaf growth phase.
A kind of artificial method for planting of medicinal raw material form nothapodytes may further comprise the steps:
(1), sets up nursery and the planting base that form nothapodytes is transplanted facility;
(2), in nursery, bring up the form nothapodytes transplanted seedling;
(3), the transplanted seedling in the step (1) being carried out the nutrition cup exposes to be completely cured and handles and put back to original position;
(4), dig in the planting base and to be used on plantation transplanted seedling kind plant hole, and in the cave, use sufficient behind the base manure 2 centimetres of backfill soil;
(5) the form nothapodytes transplanted seedling is planted kind plant hole in step (4), the temperature of planting plant hole remains on 18-26 ℃, and relative moisture remains on 68%-90%;
(6), after 40 days, transplanted seedling has been grown the 3rd more than the leaf, discharges 30 gram/nitrogenous fertilizer of every then;
(7), after about 20 centimetres of the transplanted seedling regrowths, discharge nitrogenous fertilizer 50 grams/about every again;
(8), about 50 centimetres of transplanted seedling continued growths in (7) step, to tree dispensing organic mixed fertilizer 100 grams/every;
(9), treat that tree grows tall 80-150 centimetre the time, the blade on gathering branch to the time in grain rains the Clear and Bright in every year is gathered fully at the time in the beginning of autumn to the mid-autumn in every year complete stool leaf and to be made medicinal raw material, raw material extracts the camptothecine utilization then;
(10) to after plucking leaf, setting repeating step (9).
Described raising form nothapodytes transplanted seedling is the Icacinaceae form nothapodytes.
Transplanted seedling in the described step (3) carries out the nutrition cup to be exposed to be completely cured and handles and put back to original position after 1 hour, to the transplanted seedling watering once.
In step (6), selecting does not occur growing stops the transplanted seedling of phenomenon, and transplanted seedling and its native ball taking-up of ining succession together are planted in the kind plant hole of (4) step again, and jar is once permeable after the backfill soil then.
The present invention plants the method for form nothapodytes, can utilize the sunlight plant to produce temperature better, by regulate keeping suitable temperature and humidity, and in conjunction with dispensing nitrogenous fertilizer, impel transplanted seedling again initial planting take root fast, absorb a large amount of nutrients, and transplanted seedling was grown fast towards half wooden phase, in 3-6 month, the transplanted seedling gram grows to and meets the demand of regaining raw material, shortened the time of reclaiming prepared using, secondary generally can supply raw material in 1 year.
Embodiment
A kind of step of artificial method for planting of medicinal raw material thing form nothapodytes is:
A. set up one and have the nursery of transplanting facility, set up a planting base and to its planning and designing in early stage, bring up in nursery and plant seedling, described transplanted seedling is the bulk drug plant variety that is used for being planted in the planting base that chooses;
B. the transplanted seedling among the step a is completely cured and handles and put back to original position, transplanted seedling was sprinkled water once to transplanted seedling after 1 hour after being completely cured and handling and put back to original position, to guarantee the vitality of transplanted seedling, dig in the planting base and to plant the cave, in kind of plant hole, use sufficient base manure, thereby guaranteed that matrix is loose, water-permeable and air permeable, had certain preserve moisture and fertility ability;
C. the transplanted seedling among the step a is transported to the planting base, select not occur the transfer seedling that life stops phenomenon, then carefully with transplanted seedling from dish or connecting native ball in the bag takes out in the kind plant hole of planting in step b together, irritate once permeable after the backfill soil, the temperature of planting plant hole remains on 23-28 degree centigrade, relative moisture is regulated and is remained on 75%, just display gradually 25 days stronger growth rate of left and right sides transplanted seedling, regularly discharge fertilizer then, in 3-6 month, grow tall in tree and every strain tree to be discharged 80-150 centimetre the time organic mixed manures of 50 grams again, arrived annual Clear and Bright then to grain rains, time in the beginning of autumn to the mid-autumn begins the raw material of gathering, and then the raw material of gathering is carried out processing and utilization, adopted tree is repeated step b again get final product.
In the present invention, described medicinal raw-material kind is Icacinaceae dungarunga, for example form nothapodytes.
In a word, though the present invention has exemplified last preferred embodiment, should illustrate that obviously those skilled in the art can carry out various variations and remodeling.Therefore, unless such variation and remodeling have departed from scope of the present invention, otherwise all should be included within protection scope of the present invention.
Claims (4)
1. the artificial method for planting of a medicinal raw material form nothapodytes may further comprise the steps:
(1), sets up nursery and the planting base that form nothapodytes is transplanted facility;
(2), in nursery, bring up the form nothapodytes transplanted seedling;
(3), the transplanted seedling in the step (1) being carried out the nutrition cup exposes to be completely cured and handles and put back to original position;
(4), dig in the planting base and to be used on plantation transplanted seedling kind plant hole, and in the cave, use sufficient behind the base manure 2 centimetres of backfill soil;
(5) the form nothapodytes transplanted seedling is planted kind plant hole in step (4), the temperature of planting plant hole remains on 18-26 ℃, and relative moisture remains on 68%-90%;
(6), after 40 days, transplanted seedling has been grown the 3rd more than the leaf, discharges 30 gram/nitrogenous fertilizer of every then;
(7), after about 20 centimetres of the transplanted seedling regrowths, discharge nitrogenous fertilizer 50 grams/about every again;
(8), about 50 centimetres of transplanted seedling continued growths in (7) step, to tree dispensing organic mixed fertilizer 100 grams/every;
(9), treat that tree grows tall 80-150 centimetre the time, the blade on gathering branch to the time in grain rains the Clear and Bright in every year is gathered fully at the time in the beginning of autumn to the mid-autumn in every year complete stool leaf and to be made medicinal raw material, raw material extracts the camptothecine utilization then;
(10), to after plucking leaf, setting repeating step (9).
2. the artificial method for planting of a kind of medicinal raw material form nothapodytes according to claim 1 is characterized in that described raising form nothapodytes transplanted seedling is fruit of medicinal cornel section form nothapodytes.
3. the artificial method for planting of a kind of medicinal raw material form nothapodytes according to claim 1 and 2 is characterized in that transplanted seedling in the described step (3) carries out the nutrition cup and exposes to be completely cured and handle and put back to original position after 1 hour, to the transplanted seedling watering once.
4. the artificial method for planting of a kind of medicinal raw material form nothapodytes according to claim 1 and 2, it is characterized in that, selecting does not occur growing in the step (6) stops the transplanted seedling of phenomenon, transplanted seedling and its native ball taking-up of ining succession together are planted in the kind plant hole of (4) step again, and jar is once permeable after the backfill soil then.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011104461357A CN103181272A (en) | 2011-12-28 | 2011-12-28 | Artificial planting method for medical raw materials of nothapodytes nimmoniana |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011104461357A CN103181272A (en) | 2011-12-28 | 2011-12-28 | Artificial planting method for medical raw materials of nothapodytes nimmoniana |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN103181272A true CN103181272A (en) | 2013-07-03 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2011104461357A Pending CN103181272A (en) | 2011-12-28 | 2011-12-28 | Artificial planting method for medical raw materials of nothapodytes nimmoniana |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104686147A (en) * | 2015-02-16 | 2015-06-10 | 唐忠海 | Large-scale mappia pittosporoides seedling and cultivation method |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3615240B2 (en) * | 1994-05-30 | 2005-02-02 | インデナ・ソシエタ・ペル・アチオニ | Formulations containing alkaloids and antiviral agents from Mapia Hoetida |
| CN101288376A (en) * | 2008-06-12 | 2008-10-22 | 张苑金 | Technique for reducing the maturation phase of Nothapodytes nimmoniana (Graham) Mablerley and increasing camptothecine content |
| CN101289452A (en) * | 2008-06-12 | 2008-10-22 | 张苑金 | Process for abstracting camptothecine form nothapodytes |
| CN102071234A (en) * | 2010-12-06 | 2011-05-25 | 张苑金 | Method for synthesizing 9-methoxy-18,19-dehydrocamptothecin through artificial induction of nothapodytes nimmoniana (graham) mablerley endophytes |
-
2011
- 2011-12-28 CN CN2011104461357A patent/CN103181272A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3615240B2 (en) * | 1994-05-30 | 2005-02-02 | インデナ・ソシエタ・ペル・アチオニ | Formulations containing alkaloids and antiviral agents from Mapia Hoetida |
| CN101288376A (en) * | 2008-06-12 | 2008-10-22 | 张苑金 | Technique for reducing the maturation phase of Nothapodytes nimmoniana (Graham) Mablerley and increasing camptothecine content |
| CN101289452A (en) * | 2008-06-12 | 2008-10-22 | 张苑金 | Process for abstracting camptothecine form nothapodytes |
| CN102071234A (en) * | 2010-12-06 | 2011-05-25 | 张苑金 | Method for synthesizing 9-methoxy-18,19-dehydrocamptothecin through artificial induction of nothapodytes nimmoniana (graham) mablerley endophytes |
Non-Patent Citations (1)
| Title |
|---|
| 方力为: "青脆枝快繁及抗癌有效成分分析", 《浙江林业科技》, vol. 28, no. 06, 30 November 2008 (2008-11-30) * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104686147A (en) * | 2015-02-16 | 2015-06-10 | 唐忠海 | Large-scale mappia pittosporoides seedling and cultivation method |
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| PB01 | Publication | ||
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Application publication date: 20130703 |