CN103169894B - Traditional Chinese medicine composition for treating proteinuria - Google Patents
Traditional Chinese medicine composition for treating proteinuria Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine composition for treating proteinuria. The traditional Chinese medicine composition is prepared from codonopsis pilosula, astragalus mongholicus, raw atractylodes, tuckahoe, Chinese yam, fruit of Chinese wolfberry, pulp of dogwood fruit, raw semen coicis, monkshood, cinnamon, herba epimedii, seed of Chinese dodder, lalang grass rhizome, lysimachia christinae hance, herba leonuri, angelica sinensis, yam rhizome and pyrrosia lingua according to a certain weight ratio. The traditional Chinese medicine composition has the effects of invigorating spleen and supplementing qi, tonifying kidney and fixing sperm, promoting blood circulation to remove blood stasis, and alleviating water retention and clearing damp, and can effectively treat the proteinuria.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition, be specifically related to a kind of albuminuretic Chinese medicine composition for the treatment of.
Background technology
Albuminuria is that kidney disease is compared with commonly encountered diseases.Modern medicine is more deep in pathogenesis and the research aspect pathology of nephropathy, development is very fast, but in clinical treatment meaning, be more symptomatic treatment, and the basic link of morbidity be there is no to specific treatment, and after the medicines such as life-time service hormone and anticoagulant, produce more serious toxic and side effects, embodied the limitation of existing medicine in treatment.Though TCM Document, without albuminuretic record, is followed relevant disease performance according to it, can belong to " edema, lumbago, asthenia " category.Theory of Chinese medical science thinks, albuminuretic leakage is deficiency of YIN-essence, and sealing up for safekeeping and changing life of cloudy essence is mainly kidney spleen to lead, and deficiency of spleen and stomach is.Wet, the evil poison of water producing in lysis, blood stasis etc. are mark.Pathologic feature is deficiency in origin and excess in superficiality, simulataneous insufficiency and excessive.Chinese traditional treatment albuminuria is from integral body, therefore hold back smart spermatogenesis mainly with supplementing the kidney to control the nocturnal replenishing essence, spleen invigorating clinically, effects a permanent cure, and with diuretic, toxic removing, blood stasis dispelling, takes stopgap measures as base therapy rule.Rationally application Chinese medicine, helps and eliminates albuminuria and delay renal hypofunction.
Summary of the invention
The object of this invention is to provide a kind of Chinese medicine composition, this Chinese medicine composition has evident in efficacy for treatment albuminuria, and toxic and side effects is little, taking convenience, cheap feature.
The present invention selects Radix Codonopsis, the Radix Astragali, Rhizoma Atractylodis Macrocephalae, Poria, Rhizoma Dioscoreae, Fructus Lycii, Fructus Corni, Semen Coicis, Radix Aconiti Lateralis Preparata, Cortex Cinnamomi, Herba Epimedii, Semen Cuscutae, Rhizoma Imperatae, Herba Lysimachiae, Herba Leonuri, Radix Angelicae Sinensis, Rhizoma Dioscoreae Septemlobae, Folium Pyrrosiae to combine, make each efficacy of drugs produce synergism these drug regimens, make it to there is invigorating the spleen and benefiting QI, tonifying the kidney to consolidate the essence, blood circulation promoting and blood stasis dispelling, the effect of diuretic damp eliminating, thus albuminuria can effectively be treated.
The effect of Chinese medicine of the present invention:
Wherein:
Radix Codonopsis: be the dry root of Campanulaceae Radix Codonopsis Codonopsis pilosula (Franch.) Nannf., element flower Radix Codonopsis Codonopsis pilosula Nannf.var. modesta (Nannf.) L. T. Shen or radix codonpsis tangshen Codonopsis tangshen Oliv..Sweet, the micro-acid of nature and flavor, flat.Return spleen, lung meridian.Effect: invigorating the spleen and replenishing QI, spleen invigorating lung benefiting.
The Radix Astragali: be the root of leguminous herbaceous plant's Radix Astagali, Radix Astragali.Nature and flavor are sweet, tepor.Return liver, spleen, lung, kidney channel.Effect: benefiting QI for strengthening the superficies, arresting sweating take off, hold in the palm skin ulcer granulation promoting, inducing diuresis to remove edema admittedly.
Rhizoma Atractylodis Macrocephalae: be the dry rhizome of feverfew Rhizoma Atractylodis Macrocephalae Atractylodes macrocephala Koidz..Nature and flavor are bitter, sweet, temperature.Return spleen, stomach warp.Effect: invigorating the spleen and benefiting QI, dampness diuretic, hidroschesis.
Poria: be the dry sclerotia of On Polyporaceae Poria Poria cocos (Schw.) Wolf.Nature and flavor are sweet, light, flat.GUIXIN, lung, spleen, kidney channel.Effect: promoting diuresis to eliminate damp pathogen, strengthening the spleen stomach function regulating, mind tranquilizing and the heart calming.
Rhizoma Dioscoreae: be the dry rhizome of Dioscoreaceae plant Rhizoma Dioscoreae.Nature and flavor are sweet, flat.Return spleen, lung, kidney channel.Spleen reinforcing nourishing the stomach, the lung benefiting that promotes the production of body fluid, the kidney invigorating arresting seminal emission.
Fructus Lycii: be the dry mature fruit of plant of Solanaceae lycium barbarum Lycium barbarum L..Nature and flavor are sweet, flat.Return liver, kidney, lung meridian.Effect: nourishing the liver; Nourishing kidney; Lung moistening.
Fructus Corni: be the drying and ripening sarcocarp of Cornaceae plant Fructus Corni Cornus officinalis Sieb. et Zucc..Nature and flavor acid, puckery, tepor.Return liver, kidney channel.Effect: liver and kidney tonifying, restrain astringent or styptic treatment for spontaneous sweating, controlling nocturnal emission with astringent drugs reducing urination, leukorrhagia stopping only collapses, hidroschesis, promoting the production of body fluid to quench thirst.
Semen Coicis: be the dry mature kernal of grass Semen Coicis (Coix lachryma-jobi L).Nature and flavor are sweet, light, cool.Enter spleen, lung, kidney channel.Effect: spleen invigorating, tonifying the lung, heat clearing away, dampness removing.
Radix Aconiti Lateralis Preparata: be the processed goods of the daughter root of ranunculaceae plant Aconitum carmichjaelii Debx. Aconitum carmichaeli Debx..Nature and flavor are pungent, sweet, hot greatly; Poisonous.GUIXIN, kidney, spleen channel.Effect: recuperating depleted YANG and rescuing the patient from collapse, mend fire supporing yang, dispersing cold for relieving pain.
Cortex Cinnamomi: be the dry bark of canella Cortex Cinnamomi Cinnamomum cassia Presl.The large heat of nature and flavor, pungent, sweet.Return kidney, spleen, the heart, Liver Channel.Effect: diaphoresis expelling pathogenic factors from muscles, promoting the flow of QI-blood by warming the meridian, mends fire supporing yang, let the fire back to its origin, dispersing cold for relieving pain, promoting blood circulation to restore menstrual flow.
Herba Epimedii: be the dried leaves of Berberidaceae plant Herba Epimedii (Epimedium brevicornum Maxim.), arrow leaf Herba Epimedii (Epimedium sagittatumMaxim.), pubescence Herba Epimedii (Epimedium pubescens Maxim.) or Herba Epimedii (Epimedium koreanum Nakai).Nature and flavor acrid, sweet, warm.Return liver, kidney channel.Effect: kidney-replenishing, bone and muscle strengthening, wind-damp dispelling.
Semen Cuscutae: be the dry mature seed of convolvulus cuscuta plant Cuscuta chinensis Lam..Nature and flavor are sweet, temperature.Return liver,kidney,spleen warp.Effect: nourishing the liver and kidney, controlling nocturnal emission with astringent drugs reducing urination, antiabortive, improving eyesight, antidiarrheal.
Rhizoma Imperatae: be the dry rhizome of grass Herba Imperatae Imperata cylindrical (L.) Beauv. var. major (Nees) C. E. Hubb..Nature and flavor are sweet, cold.Enter lung, stomach, small intestine meridian.Effect: removing heat from blood, hemostasis, heat clearing away, diuresis.
Herba Lysimachiae: be the dry herb of Ofthe Primulaceae Lysimachia christinae Hance Lysimachia christinae Hance.Sweet, the micro-hardship of nature and flavor, cool.Return liver, gallbladder, kidney, urinary bladder channel.Effect: relieving stranguria by diuresis; Heat-clearing and toxic substances removing; Dissipating blood stasis for subsidence of swelling.
Herba Leonuri: be the fresh or dry aerial parts of labiate Herba Leonuri Leonurus japonicus Houtt..Nature and flavor are pungent, bitter, are slightly cold.Enter the heart, liver, urinary bladder channel.Effect: invigorate blood circulation, blood stasis dispelling, regulating menstruation, water disappears.
Radix Angelicae Sinensis: be the dry root of umbelliferae angelica Angelica sinensis (Oliv.) Diels.Nature and flavor are sweet, pungent, bitter, temperature.Return liver, the heart, spleen channel.Effect: enrich blood, invigorate blood circulation, menstruction regulating and pain relieving, moisturizes laxation.
Rhizoma Dioscoreae Septemlobae: be the rhizome of Dioscoreaceae Plant Powder back of the body Rhizoma Dioscoreae.Nature and flavor are flat, hardship.Enter Liver Channel, stomach warp, urinary bladder channel.Effect: dampness removing goes turbid, blood stasis dispelling dispels the wind.
Folium Pyrrosiae: be the dried leaves of Plants of Polypodiaceae pyrrosia sheareriChing Pyrrosia sheareri (Bak.) Ching, Folium Pyrrosiae Pyrrosia lingua (Thunb.) Farwell or pyrrosia petiolosaChing Pyrrosia petiolosa (Christ) Ching.Nature and flavor are sweet, bitter, are slightly cold.Return lung, urinary bladder channel.Effect: relieving stranguria by diuresis, lung heat clearing expels the heat-evil.
Medicine material consumption of the present invention is groped in a large number to sum up through inventor and is drawn, each raw material consumption is for all to have good curative effect in following weight parts scope: Radix Codonopsis 10-20 part, Radix Astragali 45-55 part, Rhizoma Atractylodis Macrocephalae 15-25 part, Poria 10-20 part, Rhizoma Dioscoreae 13-23 part, Fructus Lycii 15-25 part, Fructus Corni 5-15 part, Semen Coicis 25-35 part, Radix Aconiti Lateralis Preparata 7-17 part, Cortex Cinnamomi 4-14 part, Herba Epimedii 15-25 part, Semen Cuscutae 25-35 part, Rhizoma Imperatae 25-35 part, Herba Lysimachiae 19-29 part, Herba Leonuri 15-25 part, Radix Angelicae Sinensis 13-23 part, Rhizoma Dioscoreae Septemlobae 13-23 part, Folium Pyrrosiae 19-29 part.
Wherein be preferably: 15 parts of Radix Codonopsis, 50 parts of the Radixs Astragali, 20 parts of Rhizoma Atractylodis Macrocephalae, 15 parts, Poria, 18 parts of Rhizoma Dioscoreaes, 20 parts of Fructus Lycii, 10 parts of Fructus Corni, 30 parts of Semen Coicis, 12 parts of Radix Aconiti Lateralis Preparatas, 9 parts of Cortex Cinnamomis, 20 parts of Herba Epimedii, 30 parts of Semen Cuscutae, 30 parts of Rhizoma Imperataes, 24 parts of Herba Lysimachiaes, 20 parts of Herba Leonuris, 18 parts of 18 parts of, Rhizoma Dioscoreae Septemlobae of Radix Angelicae Sinensis, 24 parts of Folium Pyrrosiaes.
Medicine of the present invention can adopt the conventional preparation technology of Chinese medicine preparation, can be made into said dosage form on any pharmaceutics, as pill, powder, tablet, capsule, granule, syrup, oral liquid etc.For example these crude drug grind into fine powder mix homogeneously can be made to powder takes after mixing it with water; Can use decocting, obtain after filtration filtrate, add antiseptic to make oral liquid; Also can directly take decoction if desired.
Medicine of the present invention has invigorating the spleen and benefiting QI, tonifying the kidney to consolidate the essence, blood circulation promoting and blood stasis dispelling, the effects such as diuretic damp eliminating, and evident in efficacy, toxic and side effects is little, taking convenience is cheap, according to clinical, 100 routine patients observe statistics, use 80%, two of one of the medicine of the present invention total effective rate course for the treatment of total effective rate course for the treatment of 92%.
The specific embodiment
Embodiment mono-, 10 parts of Radix Codonopsis, 45 parts of the Radixs Astragali, 15 parts of Rhizoma Atractylodis Macrocephalae, 10 parts, Poria, 13 parts of Rhizoma Dioscoreaes, 15 parts of Fructus Lycii, 5 parts of Fructus Corni, 25 parts of Semen Coicis, 7 parts of Radix Aconiti Lateralis Preparatas, 4 parts of Cortex Cinnamomis, 15 parts of Herba Epimedii, 25 parts of Semen Cuscutae, 25 parts of Rhizoma Imperataes, 19 parts of Herba Lysimachiaes, 15 parts of Herba Leonuris, 13 parts of 13 parts of, Rhizoma Dioscoreae Septemlobae of Radix Angelicae Sinensis, 19 parts of Folium Pyrrosiaes.
Embodiment bis-, 15 parts of Radix Codonopsis, 50 parts of the Radixs Astragali, 20 parts of Rhizoma Atractylodis Macrocephalae, 15 parts, Poria, 18 parts of Rhizoma Dioscoreaes, 20 parts of Fructus Lycii, 10 parts of Fructus Corni, 30 parts of Semen Coicis, 12 parts of Radix Aconiti Lateralis Preparatas, 9 parts of Cortex Cinnamomis, 20 parts of Herba Epimedii, 30 parts of Semen Cuscutae, 30 parts of Rhizoma Imperataes, 24 parts of Herba Lysimachiaes, 20 parts of Herba Leonuris, 18 parts of 18 parts of, Rhizoma Dioscoreae Septemlobae of Radix Angelicae Sinensis, 24 parts of Folium Pyrrosiaes.
Embodiment tri-, 20 parts of Radix Codonopsis, 55 parts of the Radixs Astragali, 25 parts of Rhizoma Atractylodis Macrocephalae, 20 parts, Poria, 23 parts of Rhizoma Dioscoreaes, 25 parts of Fructus Lycii, 15 parts of Fructus Corni, 35 parts of Semen Coicis, 17 parts of Radix Aconiti Lateralis Preparatas, 14 parts of Cortex Cinnamomis, 25 parts of Herba Epimedii, 35 parts of Semen Cuscutae, 35 parts of Rhizoma Imperataes, 29 parts of Herba Lysimachiaes, 25 parts of Herba Leonuris, 23 parts of 23 parts of, Rhizoma Dioscoreae Septemlobae of Radix Angelicae Sinensis, 29 parts of Folium Pyrrosiaes.
The clinical statistics data that patient uses medicine of the present invention below:
One, physical data
Accept patient's totally 100 examples for medical treatment, male's 45 examples wherein, women's 55 examples, M-F 0.8:1,33 years old mean age.
Two, diagnostic criteria:
Twenty-four-hour urine protein quantification adult surpasses 150mg/24h clinically, and child surpasses 300mg/24h, can be diagnosed as albuminuria.
Three, Therapeutic Method
According to drug weight proportioning of the present invention, weighting raw materials (daily dose), decocting, filter and remove residue, services once sooner or later, within 30th, is a course for the treatment of.
Four, efficacy assessment standard:
1, alleviate completely: subjective symptoms, sign disappear, normal renal function, urine erythrocyte, albumen continue to disappear;
2, substantially alleviate: subjective symptoms, sign disappear, normal renal function, urine erythrocyte, albumen continuous decrease >=50%;
3, take a turn for the better: symptom, sign take a turn for the better, renal function normal, urine erythrocyte, albumen continuous decrease >=25%;
4, invalid: symptom, sign be without improvement, renal function, urine examination are substantially unchanged or increase the weight of.
Five, therapeutic outcome statistics
Wherein: total effective rate=complete remission rate+basic remission rate+improvement rate
Model case and curative effect:
Case one, in certain, female, 40 years old age, because finding urine protein +++, existing three months, through multi-treatment, without being clearly better, examined afterwards light red tongue when medical, white and thin fur, moderate pulse, have a blood test fat and renal function is all normal, and patient takes Chinese medicine of the present invention after two courses for the treatment of, and check urine protein is turned out cloudy, and alleviates completely.
Case two, Pueraria lobota, man, at 26 years old age, because of albuminuria repeatedly 3 years, though through multi-treatment, all can not take a turn for the better, albumen had urine examined while examining +++, blood fat is normal, while examining face and whole body without edema, light red tongue, white and thin fur, moderate pulse.Patient takes Chinese medicine of the present invention after two courses for the treatment of, and during check, routine urinalysis is normal, alleviates completely.
Case three, Wu, female, 23 years old age, urine protein when medical because catching a cold +++, color ultrasound shows: left kidney 94 * 39mm, and right kidney 100 * 41mm, and essence Echoenhance, be diagnosed as chronic nephritis, patient takes Chinese medicine of the present invention after two courses for the treatment of, and renal function normal takes a turn for the better.
Claims (2)
1. treat albuminuretic Chinese medicine composition for one kind, it is characterized in that, this Chinese medicine composition is the ingredients by following weight portion: Radix Codonopsis 10-20 part, Radix Astragali 45-55 part, Rhizoma Atractylodis Macrocephalae 15-25 part, Poria 10-20 part, Rhizoma Dioscoreae 13-23 part, Fructus Lycii 15-25 part, Fructus Corni 5-15 part, Semen Coicis 25-35 part, Radix Aconiti Lateralis Preparata 7-17 part, Cortex Cinnamomi 4-14 part, Herba Epimedii 15-25 part, Semen Cuscutae 25-35 part, Rhizoma Imperatae 25-35 part, Herba Lysimachiae 19-29 part, Herba Leonuri 15-25 part, Radix Angelicae Sinensis 13-23 part, Rhizoma Dioscoreae Septemlobae 13-23 part, Folium Pyrrosiae 19-29 part.
2. the albuminuretic Chinese medicine composition for the treatment of according to claim 1, it is characterized in that, by the ingredients of following weight portion: 15 parts of Radix Codonopsis, 50 parts of the Radixs Astragali, 20 parts of Rhizoma Atractylodis Macrocephalae, 15 parts, Poria, 18 parts of Rhizoma Dioscoreaes, 20 parts of Fructus Lycii, 10 parts of Fructus Corni, 30 parts of Semen Coicis, 12 parts of Radix Aconiti Lateralis Preparatas, 9 parts of Cortex Cinnamomis, 20 parts of Herba Epimedii, 30 parts of Semen Cuscutae, 30 parts of Rhizoma Imperataes, 24 parts of Herba Lysimachiaes, 20 parts of Herba Leonuris, 18 parts of 18 parts of, Rhizoma Dioscoreae Septemlobae of Radix Angelicae Sinensis, 24 parts of Folium Pyrrosiaes.
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