CN103168783B - Azadirachtin emulsion composition and preparation method of azadirachtin emulsion composition - Google Patents

Abstract

Azadirachtin emulsifiable oil composition and preparation method thereof. The azadirachtin emulsifiable oil composition is composed of azadirachtin, emulsifier, penetrant, stabilizer, antifreeze agent, cosolvent and solvent, wherein the content (weight) of each component is: azadirachtin: 0.3%- 1%; Emulsifier: 8%-12%; Penetrant: 5%-8%; Stabilizer: 5%-10%; Antifreeze: 5%-10%; Co-solvent: 5%-10%; Solvent :margin. The azadirachtin emulsifiable oil composition of the present invention can fully dissolve the azadirachtin due to the synergistic effect among its components. In addition, since the vegetable oil solvent is used, the toxicity of the solvent is greatly reduced, and the obtained preparation is more environmentally friendly and safe.

Description

Azadirachtin emulsifiable oil composition and preparation method thereof

technical field

The invention relates to azadirachtin emulsifiable oil composition and a preparation method thereof. the

Background technique

The emulsifiable concentrate is a transparent liquid processed from water-insoluble raw materials, organic solvents such as benzene and xylene, and emulsifiers. It will not be turbid, stratified, or precipitated after being sealed and stored at room temperature for two years. It can be quickly and evenly dispersed when added to water. into an opaque emulsion. The characteristics of the emulsifiable concentrate are: high drug efficacy, convenient application and relatively stable properties. Due to its long history and mature processing technology, EC has many varieties, large output and wide application range. It is still a main dosage form of pesticides, but there are big problems in its use. the

The key to the EC problem is the solvent. At present, the solvents used in my country's EC are mainly volatile light aromatic solvents, which have the disadvantages of high toxicity, flammability, long half-life, and great impact on the environment. In addition, more toxic or teratogenic solvents, such as methanol and dimethylformamide, are used in some other dosage forms. Therefore, if solvents with relatively low toxicity and high safety can be used, Cream is still a good dosage form. the

Azadirachtin EC is a pesticide in the form of an emulsifiable concentrate, in which azadirachtin is a plant-derived active substance with multiple poisoning and insecticidal effects, and exists in the seeds and leaves of the neem plant of the genus Azadirachta. Because azadirachtin is easily decomposed in water, it is difficult to develop water-based products. At present, EC will still be the main dosage form of azadirachtin. Therefore, how to optimize the dosage form of azadirachtin emulsifiable concentrate, especially how to improve the dosage forms of various additives in the emulsifiable concentrate, so as to make the azadirachtin preparation more environmentally friendly and safe, is a technical problem to be solved urgently. the

Contents of the invention

The purpose of the present invention is to provide a more environmentally safe azadirachtin emulsifiable oil composition. the

According to the first aspect of the present invention, an azadirachtin emulsifiable oil composition is provided. The composition is made up of azadirachtin, emulsifier, penetrant, stabilizer, antifreeze, cosolvent and solvent, wherein the content (weight) of each component is as follows:

Azadirachtin: 0.3%-1%; Emulsifier: 8%-12%; Penetrant: 5%-8%; Stabilizer: 5%-10%; Antifreeze: 5%-10%; Cosolvent: 5%-10%; solvent: balance. the

The solvent may be selected from vegetable oils such as eucalyptus oil, turpentine-based vegetable oil, neem oil, and jatropha oil. the

The emulsifier may be selected from sorbitan monostearate, polyoxyethylene sorbitan monooleate and fatty alcohol polyoxyethylene ethers. the

The penetrant may be selected from NP-type nonionic surfactants, AEO-type nonionic surfactants, and silicones. the

Stabilizer can be selected from 2,6 di-tert-butyl p-cresol, sorbic acid, polyvinyl glycol glycidyl ether, cresyl glycidyl ether, butyl glycidyl ether and bis(2,2,6,6 - tetramethylpiperidinyl) sebacate. the

The antifreeze agent may be selected from ethylene glycol, glycerol and sorbitol. the

Co-solvents can be selected from ethanol and dibasic acid esters. the

According to another aspect of the present invention, a preparation method of the above-mentioned azadirachtin cream composition is provided. The method includes:

Fully dissolve azadirachtin with a cosolvent;

Then add 1/3 of the total amount of emulsifier and solvent to fully emulsify;

Then add the antifreeze and stabilizer and mix well; and

Finally the rest of the solvent was added and stirred. the

The azadirachtin emulsifiable oil composition prepared by the method of the invention can fully dissolve the azadirachtin due to the synergistic effect among its components. In addition, since the vegetable oil solvent is used, the toxicity of the solvent is greatly reduced, and the obtained preparation is more environmentally friendly and safe. the

Detailed ways

The azadirachtin emulsifiable oil composition of the present invention and its preparation method are described in detail below in conjunction with specific examples. the

Azadirachtin emulsifiable oil composition of the present invention is made up of azadirachtin, emulsifier, penetrating agent, stabilizer, antifreeze agent, cosolvent and solvent, and its preparation method is as follows:

Fully dissolve azadirachtin with a cosolvent;

Then add 1/3 of the total amount of emulsifier and solvent to fully emulsify;

Then add the antifreeze and stabilizer and mix well; and

Finally the rest of the solvent was added and stirring was carried out for 0.5-1 hour. the

Several specific examples of the azadirachtin emulsifiable concentrate composition of the present invention are given below. the

Azadirachtin emulsifiable oil composition 1 (the ratio of each component is weight ratio)

Azadirachtin: (0.3%);

Emulsifier: Sorbitan Monostearate (8%);

Penetrant: Alkylphenol polyoxyethylene ether (5%);

Stabilizer: 2,6 di-tert-butyl-p-cresol (5%);

Antifreeze: ethylene glycol (5%);

Co-solvent: ethanol (5%); and

Solvent: eucalyptus oil (balance). the

Azadirachtin emulsifiable oil composition 2 (the ratio of each component is weight ratio)

Azadirachtin: (0.5%);

Emulsifier: polyoxyethylene behenyl ether monooleate (10%);

Penetrant: Silicone (8%);

Stabilizer: sorbic acid (8%);

Antifreeze: glycerol (8%);

Co-solvent: dibasic acid ester (10%); and

Solvent: turpentine-based vegetable oil (balance). the

Azadirachtin emulsifiable oil composition 3 (the ratio of each component is weight ratio)

Azadirachtin: (1%);

Emulsifier: fatty alcohol polyoxyethylene ether (12%);

Penetrant: Alkylphenol polyoxyethylene ether (5%);

Stabilizer: cresyl glycidyl ether (10%);

Antifreeze: Sorbitol (10%);

Co-solvent: ethanol (8%); and

Solvent: jatropha oil (remainder). the

It should be understood by those skilled in the art that the above specific embodiments are only used to explain the present invention and not to limit it in any way. Although the azadirachtin used in the present invention can be in a purified form, other forms such as azadirachtin powder or azadirachtin extract containing active ingredients of azadirachtin can also be used, as long as the final preparation of azadirachtin cream composition contains The weight content of the azadirachtin contained is between 0.3% and 1%. For example, in the above-mentioned azadirachtin emulsifiable oil composition 1, the weight ratio of 3% azadirachtin can also be replaced by 0.72% azadirachtin powder (this neem powder contains 41% azadirachtin active ingredient) supply. the

Claims (4)

1. a nimbin emulsion composition, the weight content of each component is as follows:

Nimbin: 0.3%; Emulsifier: 8%; Bleeding agent: 5%; Stabilizing agent: 5%; Antifreeze: 5%; Cosolvent: 5%; Solvent: surplus; Wherein

Emulsifier is sorbitan monostearate;

Bleeding agent is alkylphenol polyoxyethylene;

Stabilizing agent is 2,6 BHTs;

Antifreeze is ethylene glycol;

Cosolvent is ethanol;

Solvent is volatile oil extracted from eucalyptus' leaves or twigs.

2. a nimbin emulsion composition, the weight content of each component is as follows:

Nimbin: 0.5%; Emulsifier: 10%; Bleeding agent: 8%; Stabilizing agent: 8%; Antifreeze: 8%; Cosolvent: 10%; Solvent: surplus; Wherein

Emulsifier is polyoxyethylene dehydration mountain alcohol ether monoleate;

Bleeding agent is organosilicon;

Stabilizing agent is sorbic acid;

Antifreeze is glycerine;

Cosolvent is dibasic ester;

Solvent is turpentine-based vegetable oil.

3. a nimbin emulsion composition, the weight content of each component is as follows:

Nimbin: 1%; Emulsifier: 12%; Bleeding agent: 5%; Stabilizing agent: 10%; Antifreeze: 10%; Cosolvent: 8%; Solvent: surplus; Wherein

Emulsifier is fatty alcohol-polyoxyethylene ether;

Bleeding agent is alkylphenol polyoxyethylene;

Stabilizing agent is cresyl glycidyl ether;

Antifreeze is sorbierite;

Cosolvent is ethanol;

Solvent is Jatropha curcas oil.

4. according to the preparation method of the nimbin emulsion composition described in any one in claim 1-3, comprising:

Fully dissolve nimbin with cosolvent;

Then add 1/3 of emulsifier and solvent total amount to carry out fully emulsified;

Add again antifreeze and stabilizing agent and be uniformly mixed; And finally add remaining solvent and stir.