CN103142841B - Traditional Chinese medicine composition for treating osteonecrosis of femoral head - Google Patents
Traditional Chinese medicine composition for treating osteonecrosis of femoral head Download PDFInfo
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Abstract
The invention provides a traditional Chinese medicine composition for treating osteonecrosis of the femoral head. The traditional Chinese medicine composition for treating the osteonecrosis of the femoral head comprises the following raw medicinal materials by weight: 50g of rhizoma cibotii, 40g of garter snake, 20g of leech, 20g of armadillidiam vulgare, 20g of scorpio, 40g of eupolyphaga, 50g of roasted tortoise plastron, 30g of pilous antler, 20g of native copper, 20g of sangusis draconis, 30g of rhizoma picrorhizae, 20g of radix bupleuri, 5g of hedyotis diffusa, 30g of radix cyathulae, 20g of radix achyranthis bidentatae, 40g of red ginseng, 40g of rhizoma drynariae, 30g of fructus psoraleae, 30g of bark of eucommia, 30g of himalayan teasel root, 30g of mastic, 30g of myrrh, 40g of safflower, 25g of parasitic loranthus, 30g of morinda officinalis, 30g of cistanche salsa, 20g of pyrola, 20g of Chinese angelica, 50g of prepared rehmannia root, 30g of epimedium, 20g of radix puerariae, 30g of radix ophiopogonis, 20g of berba aristolochiae mollissimae, 20g of obscured homalomena rhizome, 20g of garden balsam stem, 40-80g of herba siegesbeckiae, 20g of medicated leaven and 20g of large hawthorn. The traditional Chinese medicine composition has an exact curative effect through clinical verification and can be used for treating the osteonecrosis of the femoral head.
Description
Technical field
The present invention relates to a kind of medicine for the treatment of femur head necrosis, be specifically related to a kind of Chinese medicine composition of the treatment femur head necrosis being prepared from by Chinese herbal medicine.
Background technology
Femur head necrosis is called as " osteomyelitis " in the traditional Chinese medical science.The traditional Chinese medical science thinks that body has a delicate constitution, and resistance against diseases is low, and Liver and kidney asthenia of essence and blood, causes osteoporosis, is the potential cause of ischemic necrosis of femoral head.Pathological changes relates to liver,spleen,kidney.The kidney being the origin of congenital constitution, the raw marrow of main bone, and the strong marrow of kidney is raw, and marrow completely bone is hard.Otherwise marrow is withered, loses due regeneration capacity.Liver governing tendons store blood and kidney homology, the two honor declines together, if liver is got involved, store blood mistake department, can not normal regulating blood volume, blood operation is inconsiderate, and the difficult Ji of nutrition, is the key factor that causes femur head necrosis.The main fortune blood of spleen, dysfunction of the spleen in transportation, without activating QI source, muscles and bones muscle all depletion of QI with life.After pathological changes occurs, bone and cartilage contusion, QI and blood is obstructed, passages through which vital energy circulates stasis blocking, blood obstacle, limbs lose nutrition, and regeneration and repair ability go down, thereby produce primary disease.Femur head necrosis is a complicated pathological process, as do not treated timely and effectively in early days, will make ischemic femoral head, subside, joint space narrows down, finally cause osteoarthrosis inflammation, necrosis, make patient's hip joint function obstacle and the paralysis of disabling, patient is when suffering physiology slight illness, also will suffer decocting of psychic trauma, Ye Gei family, unit and society have increased white elephant.The medicine for the treatment of femur head necrosis is a lot of at present, also have certain therapeutic effect, but therapeutic effect significantly seldom.
Summary of the invention
In order to solve the problems of the technologies described above, the invention provides a kind of Chinese medicine composition for the treatment of femur head necrosis, it is through clinical verification, determined curative effect.
The present invention is prepared from by the crude drug of following weight: Rhizoma Cibotii 50g, Zaocys 40g, Hirudo 20g, Armadillidium 20g, Scorpio 20g, Eupolyphaga Seu Steleophaga 40g, Carapax Et Plastrum Testudinis (processed) 50g, Cornu Cervi Pantotrichum 30g, Pyritum 20g, Sanguis Draxonis 20g, Rhizoma Picrorhizae 30g, Radix Bupleuri 20g, Herba Hedyotidis Diffusae 5g, Radix Cyathulae 30g, Radix Achyranthis Bidentatae 20g, Radix Ginseng Rubra 40g, Rhizoma Drynariae 40g, Fructus Psoraleae 30g, Cortex Eucommiae 30g, Radix Dipsaci 30g, Olibanum 30g, Myrrha 30g, Flos Carthami 40g, Herba Taxilli 25g, Radix Morindae Officinalis 30g, Herba Cistanches 30g, Herba Pyrolae 20g, Radix Angelicae Sinensis 20g, Radix Rehmanniae Preparata 50g, Herba Epimedii 30g, Radix Puerariae 20g, Radix Ophiopogonis 30g, Herba Aristolochiae Mollissimae 20g, Rhizoma Homalomenae 20g, Herba speranskiae tuberculatae 20g, Herba Siegesbeckiae 40 ~ 80g, Massa Medicata Fermentata 20g, large Fructus Crataegi 20g.
Preparation method: get above each taste, mix, pulverize, add suitable quantity of water, the general piller of making, dry, obtain.
Instructions of taking: an above prescription is a course for the treatment of, and take 2-3 every day, each 6-9 gram, taking medicine after meal.
The present invention can also adopt modern pharmaceutical technology to adopt other preparation methoies as the effective ingredient in the method extraction medicines such as conventional water extraction, alcohol extraction, diafiltration, supercritical extraction, and can add pharmaceutically the adjuvant allowing to be prepared into other dosage form, as powder, big honeyed pills, tablet, granule, capsule, drop pill, slow controlled-release target preparation etc.
The present invention's formula is to come in long-term clinical practice optimization, and in side, all medicines share, and play altogether blood circulation promoting and blood stasis dispelling, removing obstruction in the collateral to relieve pain, and temperature male wind-supplying kidney, the effect of strengthening the tendons and bones, expelling wind and removing dampness, reaches the effect for the treatment of femur head necrosis, ankylosing spondylitis jointly.
The present invention is applicable to the diseases such as femur head necrosis, mandatory spondylitis, hemiplegia, intractable lumbago and skelalgia, sciatica, intervertebral disk hernia, spinal canal stenosis, amyotrophy.
clinical data
Case
Choose case 100 examples that are diagnosed as femur head necrosis, get rid of relative similar disease, and merge the heart, cerebrovascular disease, the abnormal person of hepatic and renal function, male 58 examples wherein, female's 42 examples; Age 22-71 is between year, average 57.4 years old; The elder of the course of disease 6 years, the shortest person 3 months, I phases 29 hip wherein, II phases 34 hip, III phases 31 hip, IV phases 71 hip, totally 165 hips.Standard that by stages can appointment with reference to international bone circulation science: i.e. 0 phase: x line sheet, MR I, E C T are all normal, could find osteonecrosis when only the tissue in taking out femoral head carries out cut sections for microscopic examination; The I phase: X-ray film is normal, MRI, ECT image can note abnormalities; The II phase: x line sheet, MRI, E C T all can note abnormalities, but femoral head profile is normal; The III phase: x line sheet shows that femoral head has slightly and subsides; The IV phase: X-ray film shows that collapse of the femoral head flattens; The V phase: X-ray film shows that hip joint space narrows down.
Therapeutic Method
Adopt the medicine of the embodiment of the present invention 1 preparation, a prescription was 1 course for the treatment of, and take 2-3 every day, each 6-9 gram, taking medicine after meal.Treat observe the curative effect after 3 courses for the treatment of, during treatment, avoid bearing a heavy burden, alleviating alcohol addiction smoking cessation.
Criterion of therapeutical effect
Cure: hip joint is without pain, and lower limb are without cripetura, and function is recovered completely, and imaging examination is normal.
Take a turn for the better: the hip arthralgia obviously alleviates, and hip joint movable function is good, lower limb shortening is less than l c m, and iconography femur head necrosis phenomenon is improved.
Invalid: the hip arthralgia is without obvious alleviation, and lower limb shortening is greater than l c m, X-ray film, C T check that femoral head becomes large or flat, and osteonecrosis phenomenon is unchanged.
Therapeutic outcome
Therapeutic outcome is as following table:
By above data, can be found out, the present invention is to the femur head necrosis I phase, and total effective rate reaches 100%; II phase total effective rate is 94.1%; The total effective rate of III phase is 93.8%; The total effective rate of IV phase is 71.8%.From above clinical data, medicine of the present invention has significant curative effect to femur head necrosis.
The specific embodiment
Below in conjunction with embodiment, the present invention is further illustrated.
embodiment 1
Take Rhizoma Cibotii 50g, Zaocys 40g, Hirudo 20g, Armadillidium 20g, Scorpio 20g, Eupolyphaga Seu Steleophaga 40g, Carapax Et Plastrum Testudinis (processed) 50g, Cornu Cervi Pantotrichum 30g, Pyritum 20g, Sanguis Draxonis 20g, Rhizoma Picrorhizae 30g, Radix Bupleuri 20g, Herba Hedyotidis Diffusae 5g, Radix Cyathulae 30g, Radix Achyranthis Bidentatae 20g, Radix Ginseng Rubra 40g, Rhizoma Drynariae 40g, Fructus Psoraleae 30g, Cortex Eucommiae 30g, Radix Dipsaci 30g, Olibanum 30g, Myrrha 30g, Flos Carthami 40g, Herba Taxilli 25g, Radix Morindae Officinalis 30g, Herba Cistanches 30g, Herba Pyrolae 20g, Radix Angelicae Sinensis 20g, Radix Rehmanniae Preparata 50g, Herba Epimedii 30g, Radix Puerariae 20g, Radix Ophiopogonis 30g, Herba Aristolochiae Mollissimae 20g, Rhizoma Homalomenae 20g, Herba speranskiae tuberculatae 20g, Herba Siegesbeckiae 40 ~ 80g, Massa Medicata Fermentata 20g, large Fructus Crataegi 20g, mix, pulverize, add suitable quantity of water, the general piller of making, dry, obtain.
Claims (1)
1. a Chinese medicine composition for the treatment of femur head necrosis, it is characterized in that, crude drug by following weight is prepared from: Rhizoma Cibotii 50g, Zaocys 40g, Hirudo 20g, Armadillidium 20g, Scorpio 20g, Eupolyphaga Seu Steleophaga 40g, Carapax Et Plastrum Testudinis (processed) 50g, Cornu Cervi Pantotrichum 30g, Pyritum 20g, Sanguis Draxonis 20g, Rhizoma Picrorhizae 30g, Radix Bupleuri 20g, Herba Hedyotidis Diffusae 5g, Radix Cyathulae 30g, Radix Achyranthis Bidentatae 20g, Radix Ginseng Rubra 40g, Rhizoma Drynariae 40g, Fructus Psoraleae 30g, Cortex Eucommiae 30g, Radix Dipsaci 30g, Olibanum 30g, Myrrha 30g, Flos Carthami 40g, Herba Taxilli 25g, Radix Morindae Officinalis 30g, Herba Cistanches 30g, Herba Pyrolae 20g, Radix Angelicae Sinensis 20g, Radix Rehmanniae Preparata 50g, Herba Epimedii 30g, Radix Puerariae 20g, Radix Ophiopogonis 30g, Herba Aristolochiae Mollissimae 20g, Rhizoma Homalomenae 20g, Herba speranskiae tuberculatae 20g, Herba Siegesbeckiae 40 ~ 80g, Massa Medicata Fermentata 20g, large Fructus Crataegi 20g.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105031540A (en) * | 2015-08-24 | 2015-11-11 | 王义朋 | Traditional Chinese medicine for treating ischemic femoral head necrosis |
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| CN103550456B (en) * | 2013-11-22 | 2015-09-09 | 简厚奎 | A kind of medicine for the treatment of bone disease |
| CN104306444A (en) * | 2014-11-04 | 2015-01-28 | 张华� | Traditional Chinese medicine for curing liver-kidney asthenia femoral head necrosis and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1174741C (en) * | 1999-09-21 | 2004-11-10 | Rtp药品公司 | Surface-modified particulate compositions of biologically active substances |
| CN1636578A (en) * | 2003-04-02 | 2005-07-13 | 吕守忠 | Chinese kmedicine bolus for treating femoral head necrosis and its prepn process |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1060952C (en) * | 1997-08-05 | 2001-01-24 | 朱成 | Traditional Chinese medicinal pill for curing osteonecrosis |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1174741C (en) * | 1999-09-21 | 2004-11-10 | Rtp药品公司 | Surface-modified particulate compositions of biologically active substances |
| CN1636578A (en) * | 2003-04-02 | 2005-07-13 | 吕守忠 | Chinese kmedicine bolus for treating femoral head necrosis and its prepn process |
Non-Patent Citations (2)
| Title |
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| 内外结合治疗小儿股骨头缺血性坏死30例;董庆民等;《山东中医杂志》;20090605;第28卷(第06期);402-403 * |
| 董庆民等.内外结合治疗小儿股骨头缺血性坏死30例.《山东中医杂志》.2009,第28卷(第06期), |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105031540A (en) * | 2015-08-24 | 2015-11-11 | 王义朋 | Traditional Chinese medicine for treating ischemic femoral head necrosis |
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Effective date of registration: 20140722 Address after: 252400 No. 136, Wenhua Road, Chiping County, Shandong, Liaocheng Applicant after: Zhang Haochen Address before: 250002, Shun King Garden, No. 6, Tian Jia Dong Road, Tianqiao District, Shandong, Ji'nan, 5-2-1401 Applicant before: Shi Xin |
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