CN103126972A - Skin care composition with anti-aging and whitening effects - Google Patents
Skin care composition with anti-aging and whitening effects Download PDFInfo
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- CN103126972A CN103126972A CN2013100881141A CN201310088114A CN103126972A CN 103126972 A CN103126972 A CN 103126972A CN 2013100881141 A CN2013100881141 A CN 2013100881141A CN 201310088114 A CN201310088114 A CN 201310088114A CN 103126972 A CN103126972 A CN 103126972A
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Abstract
The invention discloses a skin care composition with anti-aging and whitening effects. The skin care composition comprises the following components in parts by weight: 1-10 parts of semen coicis extracts, 1-10 parts of sanguisorba officinalis extracts, 1-10 parts of platycodon extracts, 1-10 parts of rheum officinale, 0.1-10 parts of syringa extracts, 1-10 parts of tuckahoe extracts, 1-10 parts of red alga extracts, 1-10 parts of actinidia sinensis extracts and 1-10 parts of tremella extracts. The composition provided by the invention can be used for scavenging free radicals, absorbing ultraviolet rays, inhibiting tyrosinase activity, delaying senility, preventing skin aging after being used for a long term, whitening the skin and enhancing the resistance of the skin to the outside.
Description
Technical field
The present invention relates to a kind of skin care compositions, particularly relate to a kind of skin care compositions with defying age, whitening function.
Background technology
The mankind's skin aging is divided into the aging and exogenous photoaging of endogenous physiological, and intrinsic aging can not stop, and is merely able to delay.But photoaging just can be protected.Photoaging is the chronic injury that causes under ultraviolet due to Dermal exposure.Ultraviolet B radiation (being called for short UVB) can directly act on DNA, makes it absorb energy, undergos mutation; The reactive oxygen species (ROS) that UVB and long wave ultraviolet (be called for short UVA) produce can indirect injury nucleus and mitochondrial DNA, causes the abnormal or apoptosis of cell function.The oxidable injury protein matter of ROS and lipid that the UV irradiation produces cause the abnormal of corresponding function and structure.Ultraviolet radiation can affect the skin pigment metabolism: immediate reaction is that the reactivity of melanocyte is synthetic to be increased and redistribution; Late response is that the melanocyte number increases and vigor raises.Ultraviolet can make the up-regulated of vascular endothelial cell growth factor, thereby causes hypertrophy and the expansion of blood capillary; Simultaneously, ultraviolet has immunosuppressive action, the change that causes immunocyte quantity, vigor and relevant cell factor to be expressed, but with photoaging performance dependency maximum be the change of ratio, quality and the function of UV-induced hypodermal cell epimatrix composition.The principal character of photoaging skin is clinically: pachylosis is dry, and irregular pigmentation, elasticity reduce and dark wrinkle in property.The characteristic of photoaging skin changes: collagen fiber elastic fibers organizational structure disappearance, and the deposition of amorphous elastin sample material.
Modern western medical treatment skin photoage is mainly according to its pathogeny, and reduction, antioxidation, the stimulation dermal collagen hypertrophy that the collagen protein due to inducing by degraded, the protection UV that suppresses collagen fiber is expressed, the approach such as mRNA that increase some cytokine IL-1B, TNF-α, TGF-B1 carry out.Common drug has tretinoin, hydroxyacetic acid, iron chelating agent, Botulinum toxin, ubiquinone etc.Use the laser therapy skin photoage, can also reverse the photoaging change of epidermis and corium from ultrastructure, commonly using has CO
2Laser, YAG laser, novel C O
2Laser etc. also have the Therapeutic Method such as dermabrasion, Chemical peeling.Theory of Chinese medical science think skin photoage be mainly due to deficient five internal organs, insufficiency of vital energy and blood can not go up flourish in face, body fluid not cloth be not enough to moisten and phlegm-turbidity and blood stasis resistance skin space between skin and muscles due to, therefore it is turbid as main method for the treatment of to advocate to dispel take kidney tonifying, essence replenishing, strengthening the spleen and tonifying the lung QI invigorating, promoting flow of QI and blood, blood stasis dispelling, apply in a flexible way balance internal organs negative and positive, QI and blood regulating by square medicine reach the effect of slow down aging.It is closely related that modern study thinks that traditional Chinese medical science defying age mechanism and Chinese medicine can be removed interior free yl.And Chinese medicine is of a great variety, it is natural to draw materials, and favored by people because its toxic and side effects is little again.
Summary of the invention
The purpose of this invention is to provide a kind of skin care compositions with defying age, whitening function.
Technical scheme of the present invention is summarized as follows:
A kind of skin care compositions with defying age, whitening function comprises following component by weight:
Semen Coicis extract 1-10 part, Radix Sangusorbae extract 1-10 part, Radix Platycodonis extract 1-10 part, Radix Et Rhizoma Rhei extract 1-10 part, Flos Caryophylli extract 0.1-10 part, Poria extract 1-10 part, red autumnal leaves algae extract 1-10 part, Fructus actinidiae chinensis extract 1-10 part and Tremella extract 1-10 part.
Preferably: Semen Coicis extract is that 8 parts, Radix Sangusorbae extract are that 3 parts, Radix Platycodonis extract are that 2 parts, Radix Et Rhizoma Rhei extract are that 2 parts, Flos Caryophylli extract are that 0.5 part, Poria extract are that 2 parts, red autumnal leaves algae extract are that 2 parts, Fructus actinidiae chinensis extract are that 2 parts, Tremella extract are 5 parts.
Described Semen Coicis extract is to make with following method: take Semen Coicis, adding described Semen Coicis quality 2-5 volumetric concentration doubly is the ethanol water of 1%-99.9%, put in the ultrasonic waves for cleaning instrument of 10-100kHz ultrasonic 1-5 minute, adding described Semen Coicis quality 5-10 volumetric concentration doubly is the ethanol water of 1%-99.9% again, normal heating backflow 0.5-4 hour, filter concentrated filtrate, drying;
Described Radix Sangusorbae extract is to make with following method: take Radix Sanguisorbae, adding described Radix Sanguisorbae quality 2-5 volumetric concentration doubly is the ethanol water of 1%-99.9%, put in the ultrasonic waves for cleaning instrument of 10-100kHz ultrasonic 1-5 minute, adding described Radix Sanguisorbae quality 5-10 volumetric concentration doubly is the ethanol water of 1%-99.9% again, normal heating backflow 0.5-4 hour, filter concentrated filtrate, drying;
Described Radix Platycodonis extract is to make with following method: take Radix Platycodonis, adding described Radix Platycodonis quality 2-5 volumetric concentration doubly is the ethanol water of 1%-99.9%, put in the ultrasonic waves for cleaning instrument of 10-100kHz ultrasonic 1-5 minute, adding described Radix Platycodonis quality 5-10 volumetric concentration doubly is the ethanol water of 1%-99.9% again, normal heating backflow 0.5-4 hour, filter concentrated filtrate, drying;
Described Radix Et Rhizoma Rhei extract is to make with following method: take Radix Et Rhizoma Rhei, adding described Radix Et Rhizoma Rhei quality 2-5 volumetric concentration doubly is the ethanol water of 1%-99.9%, put in the ultrasonic waves for cleaning instrument of 10-100kHz ultrasonic 1-5 minute, adding described Radix Et Rhizoma Rhei quality 5-10 volumetric concentration doubly is the ethanol water of 1%-99.9% again, normal heating backflow 0.5-4 hour, filter concentrated filtrate, drying;
Described Flos Caryophylli extract is made with following method: get the Flos Caryophylli supercritical CO
2Extraction, extracting pressure are that 5-20MPa, extraction temperature 20-50 ℃, extraction time 0.5-5 hour namely get the Flos Caryophylli extract;
Described Poria extract is to make with following method: take Poria, add described Poria quality 2-5 water doubly, put in the ultrasonic waves for cleaning instrument of 10-100kHz ultrasonic 1-5 minute, add described Poria quality 5-10 water doubly, normal heating backflow 0.5-4 hour filters again, concentrated filtrate, drying;
Described red autumnal leaves algae extract is to make with following method: take the red autumnal leaves algae, add described red autumnal leaves algae quality 2-5 water doubly, put in the ultrasonic waves for cleaning instrument of 10-100kHz ultrasonic 1-5 minute, add again described red autumnal leaves algae quality 5-10 water doubly, normal heating backflow 0.5-4 hour, filter concentrated filtrate, drying;
Described Fructus actinidiae chinensis extract is to make with following method: take Fructus actinidiae chinensis, adding described Fructus actinidiae chinensis quality 2-5 volumetric concentration doubly is the ethanol water of 1%-99.9%, put in the ultrasonic waves for cleaning instrument of 10-100kHz ultrasonic 1-5 minute, adding described Fructus actinidiae chinensis quality 5-10 volumetric concentration doubly is the ethanol water of 1%-99.9% again, normal heating backflow 0.5-4 hour, filter concentrated filtrate, drying;
Described Tremella extract is to make with following method: take Tremella, add described Tremella quality 2-5 water doubly, put in the ultrasonic waves for cleaning instrument of 10-100kHz ultrasonic 1-5 minute, add described Tremella quality 5-10 water doubly, normal heating backflow 0.5-4 hour filters again, concentrated filtrate, drying.
Preferably Semen Coicis extract is to make with following method: take Semen Coicis, the volumetric concentration that adds 3 times of described Semen Coicis quality is 75% ethanol water, put in the ultrasonic waves for cleaning instrument of 85kHz ultrasonic 4 minutes, the volumetric concentration that adds again 7 times of described Semen Coicis quality is 75% ethanol water, normal heating refluxed 3 hours, filter concentrated filtrate, drying.
Preferably Radix Sangusorbae extract is to make with following method: take Radix Sanguisorbae, the volumetric concentration that adds 3 times of described Radix Sanguisorbae quality is 60% ethanol water, put in the ultrasonic waves for cleaning instrument of 85kHz ultrasonic 4 minutes, the volumetric concentration that adds again 7 times of described Radix Sanguisorbae quality is 60% ethanol water, normal heating refluxed 3 hours, filter concentrated filtrate, drying.
Preferably Radix Platycodonis extract is to make with following method: take Radix Platycodonis, the volumetric concentration that adds 4 times of described Radix Platycodonis quality is 75% ethanol water, put in the ultrasonic waves for cleaning instrument of 85kHz ultrasonic 4 minutes, the volumetric concentration that adds again 7 times of described Radix Platycodonis quality is 75% ethanol water, normal heating refluxed 3 hours, filter concentrated filtrate, drying.
Preferably Radix Et Rhizoma Rhei extract is to make with following method: take Radix Et Rhizoma Rhei, the volumetric concentration that adds 4.5 times of described Radix Et Rhizoma Rhei quality is 45% ethanol water, put in the ultrasonic waves for cleaning instrument of 85kHz ultrasonic 4 minutes, the volumetric concentration that adds again 9 times of described Radix Et Rhizoma Rhei quality is 45% ethanol water, normal heating refluxed 3 hours, filter concentrated filtrate, drying.
Preferably Poria extract is to make with following method: take Poria, add the water of 4 times of described Poria quality, put in the ultrasonic waves for cleaning instrument of 85kHz ultrasonic 4 minutes, the water that adds again 9 times of described Poria quality, normal heating refluxed 3 hours, filtered, concentrated filtrate, drying.
Preferably red autumnal leaves algae extract is to make with following method: take the red autumnal leaves algae, add the water of 3 times of described red autumnal leaves algae quality, put in the ultrasonic waves for cleaning instrument of 85kHz ultrasonic 3 minutes, the water that adds again 7 times of described red autumnal leaves algae quality, normal heating refluxed 3 hours, filtered, concentrated filtrate, drying.
Preferably Fructus actinidiae chinensis extract is to make with following method: take Fructus actinidiae chinensis, the volumetric concentration that adds 3 times of described Fructus actinidiae chinensis quality is 60% ethanol water, put in the ultrasonic waves for cleaning instrument of 85kHz ultrasonic 3 minutes, the volumetric concentration that adds again 7 times of described Fructus actinidiae chinensis quality is 60% ethanol water, normal heating refluxed 3 hours, filter concentrated filtrate, drying; Described Tremella extract is to make with following method: take Tremella, add the water of 4 times of described Tremella quality, put in the ultrasonic waves for cleaning instrument of 85kHz ultrasonic 3 minutes, the water that adds again 9 times of described Tremella quality, normal heating refluxed 3 hours, filtered, concentrated filtrate, drying.
Compositions of the present invention can be removed free radical, absorbs ultraviolet, and restraint of tyrosinase is active, slow down aging, life-time service can prevent skin aging, can skin whitening, and strengthen skin resistance to external world.
The specific embodiment
Below in conjunction with specific embodiment, the present invention is done further invention.
Embodiment 1
A kind of skin care compositions with defying age, whitening function comprises following component by weight:
5 parts of 8 parts of Semen Coicis extracts, 3 parts of Radix Sangusorbae extracts, 2 parts of Radix Platycodonis extracts, 2 parts of Radix Et Rhizoma Rhei extracts, 0.5 part of Flos Caryophylli extract, 2 parts of Poria extracts, 2 parts of red autumnal leaves algae extracts, 2 parts of Fructus actinidiae chinensis extracts and Tremella extracts.
Semen Coicis extract is to make with following method: take Semen Coicis, the volumetric concentration that adds 3 times of described Semen Coicis quality is 75% ethanol water, put in the ultrasonic waves for cleaning instrument of 85kHz ultrasonic 4 minutes, the volumetric concentration that adds again 7 times of described Semen Coicis quality is 75% ethanol water, normal heating refluxed 3 hours, filter concentrated filtrate, drying;
Radix Sangusorbae extract is to make with following method: take Radix Sanguisorbae, the volumetric concentration that adds 3 times of described Radix Sanguisorbae quality is 60% ethanol water, put in the ultrasonic waves for cleaning instrument of 85kHz ultrasonic 4 minutes, the volumetric concentration that adds again 7 times of described Radix Sanguisorbae quality is 60% ethanol water, normal heating refluxed 3 hours, filter concentrated filtrate, drying.
Radix Platycodonis extract is to make with following method: take Radix Platycodonis, the volumetric concentration that adds 4 times of described Radix Platycodonis quality is 75% ethanol water, put in the ultrasonic waves for cleaning instrument of 85kHz ultrasonic 4 minutes, the volumetric concentration that adds again 7 times of described Radix Platycodonis quality is 75% ethanol water, normal heating refluxed 3 hours, filter concentrated filtrate, drying.
Radix Et Rhizoma Rhei extract is to make with following method: take Radix Et Rhizoma Rhei, the volumetric concentration that adds 4.5 times of described Radix Et Rhizoma Rhei quality is 45% ethanol water, put in the ultrasonic waves for cleaning instrument of 85kHz ultrasonic 4 minutes, the volumetric concentration that adds again 9 times of described Radix Et Rhizoma Rhei quality is 45% ethanol water, normal heating refluxed 3 hours, filter concentrated filtrate, drying.
The Flos Caryophylli extract is made with following method: get the Flos Caryophylli supercritical CO
2Extraction, extracting pressure are that 10MPa, 35 ℃ of extraction temperature, extraction time namely got the Flos Caryophylli extract in 1.5 hours;
Poria extract is to make with following method: take Poria, add the water of 4 times of described Poria quality, put in the ultrasonic waves for cleaning instrument of 85kHz ultrasonic 4 minutes, the water that adds again 9 times of described Poria quality, normal heating refluxed 3 hours, filtered, concentrated filtrate, drying.
Red autumnal leaves algae extract is to make with following method: take the red autumnal leaves algae, add the water of 3 times of described red autumnal leaves algae quality, put in the ultrasonic waves for cleaning instrument of 85kHz ultrasonic 3 minutes, the water that adds again 7 times of described red autumnal leaves algae quality, normal heating refluxed 3 hours, filtered, concentrated filtrate, drying.
Fructus actinidiae chinensis extract is to make with following method: take Fructus actinidiae chinensis, the volumetric concentration that adds 3 times of described Fructus actinidiae chinensis quality is 60% ethanol water, put in the ultrasonic waves for cleaning instrument of 85kHz ultrasonic 3 minutes, the volumetric concentration that adds again 7 times of described Fructus actinidiae chinensis quality is 60% ethanol water, normal heating refluxed 3 hours, filter concentrated filtrate, drying;
Tremella extract is to make with following method: take Tremella, add the water of 4 times of described Tremella quality, put in the ultrasonic waves for cleaning instrument of 85kHz ultrasonic 3 minutes, the water that adds again 9 times of described Tremella quality, normal heating refluxed 3 hours, filtered, concentrated filtrate, drying.
Embodiment 2
A kind of skin care compositions with defying age, whitening function comprises following component by weight:
1 part of 1 part of Semen Coicis extract, 10 parts of Radix Sangusorbae extracts, 5 parts of Radix Platycodonis extracts, 2 parts of Radix Et Rhizoma Rhei extracts, 0.1 part of Flos Caryophylli extract, 10 parts of Poria extracts, 5 parts of red autumnal leaves algae extracts, 2 parts of Fructus actinidiae chinensis extracts and Tremella extract.
Semen Coicis extract is to make with following method: take Semen Coicis, the volumetric concentration that adds 2 times of described Semen Coicis quality is 99.9% ethanol water, put in the ultrasonic waves for cleaning instrument of 10kHz ultrasonic 5 minutes, the volumetric concentration that adds again 5 times of described Semen Coicis quality is 99.9% ethanol water, normal heating refluxed 0.5 hour, filter concentrated filtrate, drying;
Radix Sangusorbae extract is to make with following method: take Radix Sanguisorbae, the volumetric concentration that adds 2 times of described Radix Sanguisorbae quality is 99.9% ethanol water, put in the ultrasonic waves for cleaning instrument of 10kHz ultrasonic 5 minutes, the volumetric concentration that adds again 5 times of described Radix Sanguisorbae quality is 99.9% ethanol water, normal heating refluxed 0.5 hour, filter concentrated filtrate, drying;
Radix Platycodonis extract is to make with following method: take Radix Platycodonis, the volumetric concentration that adds 2 times of described Radix Platycodonis quality is 99.9% ethanol water, put in the ultrasonic waves for cleaning instrument of 10kHz ultrasonic 5 minutes, the volumetric concentration that adds again 5 times of described Radix Platycodonis quality is 99.9% ethanol water, normal heating refluxed 0.5 hour, filter concentrated filtrate, drying;
Radix Et Rhizoma Rhei extract is to make with following method: take Radix Et Rhizoma Rhei, the volumetric concentration that adds 2 times of described Radix Et Rhizoma Rhei quality is 99.9% ethanol water, put in the ultrasonic waves for cleaning instrument of 10kHz ultrasonic 5 minutes, the volumetric concentration that adds again 5 times of described Radix Et Rhizoma Rhei quality is 99.9% ethanol water, normal heating refluxed 0.5 hour, filter concentrated filtrate, drying;
The Flos Caryophylli extract is made with following method: get the Flos Caryophylli supercritical CO
2Extraction, extracting pressure are that 5MPa, 20 ℃ of extraction temperature, extraction time namely got the Flos Caryophylli extract in 5 hours;
Poria extract is to make with following method: take Poria, add the water of 2 times of described Poria quality, put in the ultrasonic waves for cleaning instrument of 100kHz ultrasonic 1 minute, the water that adds again 5 times of described Poria quality, normal heating refluxed 0.5 hour, filtered, concentrated filtrate, drying;
Red autumnal leaves algae extract is to make with following method: take the red autumnal leaves algae, add the water of 2 times of described red autumnal leaves algae quality, put in the ultrasonic waves for cleaning instrument of 100kHz ultrasonic 1 minute, the water that adds again 5 times of described red autumnal leaves algae quality, normal heating refluxed 0.5 hour, filtered, concentrated filtrate, drying;
Fructus actinidiae chinensis extract is to make with following method: take Fructus actinidiae chinensis, the volumetric concentration that adds 2 times of described Fructus actinidiae chinensis quality is 99.9% ethanol water, put in the ultrasonic waves for cleaning instrument of 10kHz ultrasonic 5 minutes, the volumetric concentration that adds again 5 times of described Fructus actinidiae chinensis quality is 99.9% ethanol water, normal heating refluxed 0.5 hour, filter concentrated filtrate, drying;
Tremella extract is to make with following method: take Tremella, add the water of 2 times of described Tremella quality, put in the ultrasonic waves for cleaning instrument of 10kHz ultrasonic 5 minutes, the water that adds again 5 times of described Tremella quality, normal heating refluxed 0.5 hour, filtered, concentrated filtrate, drying.
Embodiment 3
A kind of skin care compositions with defying age, whitening function comprises following component by weight:
5 parts of 5 parts of Semen Coicis extracts, 1 part of Radix Sangusorbae extract, 10 parts of Radix Platycodonis extracts, 5 parts of Radix Et Rhizoma Rhei extracts, 0.5 part of Flos Caryophylli extract, 1 part of Poria extract, 10 parts of red autumnal leaves algae extracts, 5 parts of Fructus actinidiae chinensis extracts and Tremella extracts.
Semen Coicis extract is to make with following method: take Semen Coicis, the volumetric concentration that adds 3 times of described Semen Coicis quality is 80% ethanol water, put in the ultrasonic waves for cleaning instrument of 50kHz ultrasonic 4 minutes, the volumetric concentration that adds again 6 times of described Semen Coicis quality is 80% ethanol water, normal heating refluxed 1 hour, filter concentrated filtrate, drying;
Radix Sangusorbae extract is to make with following method: take Radix Sanguisorbae, the volumetric concentration that adds 3 times of described Radix Sanguisorbae quality is 80% ethanol water, put in the ultrasonic waves for cleaning instrument of 50kHz ultrasonic 3 minutes, the volumetric concentration that adds again 6 times of described Radix Sanguisorbae quality is 80% ethanol water, normal heating refluxed 2 hours, filter concentrated filtrate, drying;
Radix Platycodonis extract is to make with following method: take Radix Platycodonis, the volumetric concentration that adds 3 times of described Radix Platycodonis quality is 75% ethanol water, put in the ultrasonic waves for cleaning instrument of 50kHz ultrasonic 3 minutes, the volumetric concentration that adds again 8 times of described Radix Platycodonis quality is 80% ethanol water, normal heating refluxed 2 hours, filter concentrated filtrate, drying;
Radix Et Rhizoma Rhei extract is to make with following method: take Radix Et Rhizoma Rhei, the volumetric concentration that adds 3 times of described Radix Et Rhizoma Rhei quality is 80% ethanol water, put in the ultrasonic waves for cleaning instrument of 50kHz ultrasonic 3 minutes, the volumetric concentration that adds again 7 times of described Radix Et Rhizoma Rhei quality is 75% ethanol water, normal heating refluxed 2 hours, filter concentrated filtrate, drying;
The Flos Caryophylli extract is made with following method: get the Flos Caryophylli supercritical CO
2Extraction, extracting pressure are that 10MPa, 30 ℃ of extraction temperature, extraction time namely got the Flos Caryophylli extract in 4 hours;
Poria extract is to make with following method: take Poria, add the water of 3 times of described Poria quality, put in the ultrasonic waves for cleaning instrument of 80kHz ultrasonic 3 minutes, the water that adds again 6 times of described Poria quality, normal heating refluxed 2 hours, filtered, concentrated filtrate, drying;
Red autumnal leaves algae extract is to make with following method: take the red autumnal leaves algae, add the water of 3 times of described red autumnal leaves algae quality, put in the ultrasonic waves for cleaning instrument of 80kHz ultrasonic 3 minutes, the water that adds again 6 times of described red autumnal leaves algae quality, normal heating refluxed 2 hours, filtered, concentrated filtrate, drying;
Fructus actinidiae chinensis extract is to make with following method: take Fructus actinidiae chinensis, the volumetric concentration that adds 3 times of described Fructus actinidiae chinensis quality is 70% ethanol water, put in the ultrasonic waves for cleaning instrument of 50kHz ultrasonic 3 minutes, the volumetric concentration that adds again 8 times of described Fructus actinidiae chinensis quality is 70% ethanol water, normal heating refluxed 2 hours, filter concentrated filtrate, drying;
Tremella extract is to make with following method: take Tremella, add the water of 3 times of described Tremella quality, put in the ultrasonic waves for cleaning instrument of 50kHz ultrasonic 3 minutes, the water that adds again 8 times of described Tremella quality, normal heating refluxed 2 hours, filtered, concentrated filtrate, drying.
Embodiment 4
A kind of skin care compositions with defying age, whitening function comprises following component by weight:
8 parts of 8 parts of Semen Coicis extracts, 3 parts of Radix Sangusorbae extracts, 1 part of Radix Platycodonis extract, 10 parts of Radix Et Rhizoma Rhei extracts, 5 parts of Flos Caryophylli extracts, 2 parts of Poria extracts, 1 part of red autumnal leaves algae extract, 10 parts of Fructus actinidiae chinensis extracts and Tremella extracts.
Semen Coicis extract is to make with following method: take Semen Coicis, the volumetric concentration that adds 4 times of described Semen Coicis quality is 50% ethanol water, put in the ultrasonic waves for cleaning instrument of 85kHz ultrasonic 2 minutes, the volumetric concentration that adds again 7 times of described Semen Coicis quality is 50% ethanol water, normal heating refluxed 2 hours, filter concentrated filtrate, drying;
Radix Sangusorbae extract is to make with following method: take Radix Sanguisorbae, the volumetric concentration that adds 4 times of described Radix Sanguisorbae quality is 50% ethanol water, put in the ultrasonic waves for cleaning instrument of 85kHz ultrasonic 2 minutes, the volumetric concentration that adds again 7 times of described Radix Sanguisorbae quality is 50% ethanol water, normal heating refluxed 3 hours, filter concentrated filtrate, drying;
Radix Platycodonis extract is to make with following method: take Radix Platycodonis, the volumetric concentration that adds 4 times of described Radix Platycodonis quality is 50% ethanol water, put in the ultrasonic waves for cleaning instrument of 85kHz ultrasonic 2 minutes, the volumetric concentration that adds again 9 times of described Radix Platycodonis quality is 50% ethanol water, normal heating refluxed 3 hours, filter concentrated filtrate, drying;
Radix Et Rhizoma Rhei extract is to make with following method: take Radix Et Rhizoma Rhei, the volumetric concentration that adds 4 times of described Radix Et Rhizoma Rhei quality is 50% ethanol water, put in the ultrasonic waves for cleaning instrument of 85kHz ultrasonic 2 minutes, the volumetric concentration that adds again 8 times of described Radix Et Rhizoma Rhei quality is 50% ethanol water, normal heating refluxed 3 hours, filter concentrated filtrate, drying;
The Flos Caryophylli extract is made with following method: get the Flos Caryophylli supercritical CO
2Extraction, extracting pressure are that 15MPa, 40 ℃ of extraction temperature, extraction time namely got the Flos Caryophylli extract in 1 hour;
Poria extract is to make with following method: take Poria, add the water of 4 times of described Poria quality, put in the ultrasonic waves for cleaning instrument of 50kHz ultrasonic 4 minutes, the water that adds again 8 times of described Poria quality, normal heating refluxed 3 hours, filtered, concentrated filtrate, drying;
Red autumnal leaves algae extract is to make with following method: take the red autumnal leaves algae, add the water of 4 times of described red autumnal leaves algae quality, put in the ultrasonic waves for cleaning instrument of 50kHz ultrasonic 4 minutes, the water that adds again 7 times of described red autumnal leaves algae quality, normal heating refluxed 3 hours, filtered, concentrated filtrate, drying;
Fructus actinidiae chinensis extract is to make with following method: take Fructus actinidiae chinensis, the volumetric concentration that adds 4 times of described Fructus actinidiae chinensis quality is 50% ethanol water, put in the ultrasonic waves for cleaning instrument of 80kHz ultrasonic 2 minutes, the volumetric concentration that adds again 9 times of described Fructus actinidiae chinensis quality is 50% ethanol water, normal heating refluxed 3 hours, filter concentrated filtrate, drying;
Tremella extract is to make with following method: take Tremella, add the water of 4 times of described Tremella quality, put in the ultrasonic waves for cleaning instrument of 70kHz ultrasonic 2 minutes, the water that adds again 9 times of described Tremella quality, normal heating refluxed 3 hours, filtered, concentrated filtrate, drying.
Embodiment 5
A kind of skin care compositions with defying age, whitening function comprises following component by weight:
10 parts of 10 parts of Semen Coicis extracts, 5 parts of Radix Sangusorbae extracts, 2 parts of Radix Platycodonis extracts, 1 part of Radix Et Rhizoma Rhei extract, 10 parts of Flos Caryophylli extracts, 5 parts of Poria extracts, 2 parts of red autumnal leaves algae extracts, 1 part of Fructus actinidiae chinensis extract and Tremella extracts.
Semen Coicis extract is to make with following method: take Semen Coicis, the volumetric concentration that adds 5 times of described Semen Coicis quality is 1% ethanol water, put in the ultrasonic waves for cleaning instrument of 100kHz ultrasonic 1 minute, the volumetric concentration that adds again 10 times of described Semen Coicis quality is 1% ethanol water, normal heating refluxed 4 hours, filter concentrated filtrate, drying;
Radix Sangusorbae extract is to make with following method: take Radix Sanguisorbae, the volumetric concentration that adds 5 times of described Radix Sanguisorbae quality is 1% ethanol water, put in the ultrasonic waves for cleaning instrument of 100kHz ultrasonic 1 minute, the volumetric concentration that adds again 10 times of described Radix Sanguisorbae quality is 1% ethanol water, normal heating refluxed 4 hours, filter concentrated filtrate, drying;
Radix Platycodonis extract is to make with following method: take Radix Platycodonis, the volumetric concentration that adds 5 times of described Radix Platycodonis quality is 1% ethanol water, put in the ultrasonic waves for cleaning instrument of 100kHz ultrasonic 1 minute, the volumetric concentration that adds again 10 times of described Radix Platycodonis quality is 1% ethanol water, normal heating refluxed 4 hours, filter concentrated filtrate, drying;
Radix Et Rhizoma Rhei extract is to make with following method: take Radix Et Rhizoma Rhei, the volumetric concentration that adds 5 times of described Radix Et Rhizoma Rhei quality is 1% ethanol water, put in the ultrasonic waves for cleaning instrument of 100kHz ultrasonic 1 minute, the volumetric concentration that adds again 10 times of described Radix Et Rhizoma Rhei quality is 1% ethanol water, normal heating refluxed 4 hours, filter concentrated filtrate, drying;
The Flos Caryophylli extract is made with following method: get the Flos Caryophylli supercritical CO
2Extraction, extracting pressure are that 20MPa, 50 ℃ of extraction temperature, extraction time namely got the Flos Caryophylli extract in 0.5 hour;
Poria extract is to make with following method: take Poria, add the water of 5 times of described Poria quality, put in the ultrasonic waves for cleaning instrument of 10kHz ultrasonic 5 minutes, the water that adds again 10 times of described Poria quality, normal heating refluxed 4 hours, filtered, concentrated filtrate, drying;
Red autumnal leaves algae extract is to make with following method: take the red autumnal leaves algae, add the water of 5 times of described red autumnal leaves algae quality, put in the ultrasonic waves for cleaning instrument of 10kHz ultrasonic 5 minutes, the water that adds again 10 times of described red autumnal leaves algae quality, normal heating refluxed 4 hours, filtered, concentrated filtrate, drying;
Fructus actinidiae chinensis extract is to make with following method: take Fructus actinidiae chinensis, the volumetric concentration that adds 5 times of described Fructus actinidiae chinensis quality is 1% ethanol water, put in the ultrasonic waves for cleaning instrument of 100kHz ultrasonic 1 minute, the volumetric concentration that adds again 10 times of described Fructus actinidiae chinensis quality is 1% ethanol water, normal heating refluxed 4 hours, filter concentrated filtrate, drying;
Tremella extract is to make with following method: take Tremella, add the water of 5 times of described Tremella quality, put in the ultrasonic waves for cleaning instrument of 100kHz ultrasonic 1 minute, the water that adds again 10 times of described Tremella quality, normal heating refluxed 4 hours, filtered, concentrated filtrate, drying.
Embodiment 6 contains the preparation of the essence of a kind of skin care compositions with defying age, whitening function of the present invention:
Take the compositions of the various embodiments described above, (in each embodiment, the weight portion of each component changes gram into, for example 8 parts of Semen Coicis extracts change Semen Coicis extract 8 grams into, by that analogy) add again carbopol 940 resin 2g, 1,3 butanediol 50g, hydroxyethyl-cellulose 1g, triethanolamine 1.8g, deionized water adds to 1000g, and mixing gets final product.
The said goods evenly is applied in facial getting final product in right amount.
Embodiment 7
Experiment
One, the mensuration of SOD, MDA, hydroxyproline
1 material
1.1 animal.70 of SD rats, body weight 180 ± 20g, ♀ ♂ half and half.
1.2 material and reagent.Compositions of the present invention is pressed the essence of the method preparation of embodiment 6; SOD mensuration test kit, MDA measure test kit, the hydroxyproline determination test kit builds up bio-engineering research by Nanjing and provides.
1.3 key instrument.Ultraviolet lamp tube (the Nanjing China limited department of forceful electric power, 80WUVA lamp and 160W UVB lamp); Uitraviolet intensity analyzer (Mei Ying Pu, Shanghai instrument and meter Manufacturing Co., Ltd, model: the ZQJ-254 type); Ultra-violet and visible spectrophotometer (east of a river, Suzhou precision instrument company limited, model: 752N); (magnetic electronic Science and Technology Ltd., model: the T10 type) are got in Shanghai in tissue refiner.
2 methods
2.1 animal grouping and administration.
Be divided at random 7 groups;
Matched group (being normal group): do not carry out ultra-vioket radiation and not administration;
Matrix group: rat is carrying out ultraviolet radiation and was smearing in front 10 minutes the mixed liquor of the adjuvant of equivalent embodiment 6 except a kind of skin care compositions with defying age, whitening function;
Of the present invention group (embodiment 1-5 presses the essence of embodiment 6 preparation, is called for short successively essence 1-essence 5): rat was smeared essence in front 10 minutes carrying out ultraviolet radiation, and 5ml/ only.
2.2 modeling
Except normal group, all the other respectively organize rat with 10%Na
2The S aqueous solution is got center, back skin depilatory, exposes 2cm * 2cm size skin.Simulation UV irradiation.Radiation source: UVA lamp 80W and UVB lamp 160W.Light source the distance rat approximately 40cm shine at the place.Shine 1 the 1st every day in week, each 1h, and the 2nd week rose and shines 2 times every day, each 40min, prolonged exposure to accumulative total exposure dose reaches UVA304.5J/cm
2, UVB6.3J/cm
2
2.3 draw materials.
After the 60th day last irradiation 2h, take off cervical vertebra and put to death rat, get the approximately 1cm of position skin that loses hair or feathers
2, the work done in the manner of a certain author hydroxyproline content detects; Remainder depilation skin of back 0.1g left and right, work done in the manner of a certain author MDA and SOD detect.
2.4 hydroxyproline content detects.
Accurately take the 0.050g skin histology, add in 95～100 ℃ of hydrolyzed solutions to be hydrolyzed 40min, centrifugal 10min gets supernatant and strictly detects by hydroxyproline determination test kit operating instruction.
2.5MDA, the SOD content detection.
Got the skin histology of 0.1 left and right with pre-cold saline rinsing, remove connective tissue and subcutaneous fat, filter paper is wiped away dried weighing, pour in interior cut homogenate tube after tissue is shredded, measure the pre-cold saline of 9 times of these skin histology weight, first take a morsel to pour into and be equipped with in piece of tissue homogenizer, homogenate 15min in frozen water, then pour the residue normal saline into, make 10% tissue homogenate.10% tissue homogenate is got supernatant with the centrifugal 10min of 3000r/min standby.Strictly press MDA, the detection of SOD test kit operating instruction.
2.6 statistical method.
(X ± S) expression is carried out check between variance analysis and group with SPSS11.5 software to result with mean ± standard deviation.
3 results
3.1 rat skin general state.
The normal rats skin surface is smooth flexible, and texture is clear, without wrinkle; There is obvious erythema on matrix group rat skin surface, follows the string and gloss, and keratinization of epidermis, coarse companion's desquamation have dark fold; Of the present invention group of rat skin wrinkle is not obvious, near normal rats skin.
3.2 the impact of the essence of various embodiments of the present invention compositions preparation on rat skin SOD, MDA.
See Table 1.With normal group relatively, matrix group skin SOD active significantly reduce (P＜0.01), MDA level significantly raise (P＜0.01).The essence group of present composition preparation is compared with matrix group, and the skin SOD activity all obviously raises (P＜0.01), MDA content obviously reduces (P＜0.01).
3.3 the impact of the essence of present composition preparation on the rat skin hydroxyproline content.See Table 1.
Table 1 pharmaceutical composition of the present invention is on rat skin SOD, MDA, hydroxyproline content impact (X ± S, N=10)
Annotate: compare * * P＜0.01 with matrix group.
In this experimental result, it is active that the present composition can obviously strengthen photoaging rat skin tissue SOD, reduces MDA content, shows that the present composition can strengthen the oxidation resistance of skin histology, reduce the skin histology free-radical contents, the effect of performance delaying skin photoaging.
Two, on the inhibiting impact of tryrosinase
1.2 reagent: the L-Dopa(Sigma 333786-250MG of company); Mushroom Tyrosinase (Sigma company's T 3824-25KU); Other reagent are commercially available analytical pure.
1.3 instrument: Shimadzu UV-2501 type ultraviolet spectrophotometer, the upper Nereid FN1004N of section analytical balance, Tianjin Ao Tesaisisi 20500 Ultrasound Instrument, SY21-K type thermostat water bath, micropipettor.
1.4.2 reagent preparation
Phosphate buffered solution (PBS): get 0.2mol/L potassium dihydrogen phosphate 250ml, add 0.2mol/L sodium hydroxide solution 118ml, be diluted with water to 1000ml, shake up, and get final product.
Tryrosinase solution: face the used time and use PBS(pH6.83) preparation, concentration 10u/ml;
L-Dopa solution: face the used time and use PBS(pH6.83) preparation, mass fraction is 0.05%);
Sample solution: the compositions of embodiment 1-5 is used PBS(pH6.83 facing the used time respectively) preparation, be mixed with 100mg/ml.
1.4.3 the mensuration of tyrosinase activity
Before mensuration, accurately prepare with micropipettor:
A1 test specimens: 2mlPBS+1ml tryrosinase solution;
A2 test specimens: 3mlPBS;
A3 test specimens: 1ml sample solution+1mlPBS+1ml tryrosinase solution;
A4 test specimens: 1ml sample solution+2mlPBS.
Establish parallel 2 groups of test tubes for every group, first put in 25 ℃ of water-baths and add respectively immediately L-Dopa solution 1ml, mixing after insulation 10min.React 2min immediately in 475nm place's survey absorbance with 25 ℃ of constant temperature water baths.
Tyrosinase activity suppression ratio (%)=[(A1-A2)-(A3-A4)]/(A1-A2) * 100
A1 does not add the enzyme mixation that adds of the present composition.
A2 does not add the liquid of the present composition and enzyme.
A3 adds the mixed liquor of the present composition and enzyme.
A4 adds the present composition and not enzyme-added mixed liquor.
2 results and analysis
By every group of parallel repetition of above-mentioned experimental technique 2 times, the addition of O.D value is averaged.Press the tyrosinase inhibition rate formula and calculate, the results are shown in Table 2.
Table 2 pharmaceutical composition of the present invention is to the tyrosinase activity rejection ratio
| Group | Suppression ratio % |
| The Vc matched group | 45.21±3.02 |
| Embodiment 1 | 67.21±2.54 |
| Embodiment 2 | 62.36±1.52 |
| Embodiment 3 | 63.68±2.30 |
| Embodiment 4 | 62.24±3.04 |
| Embodiment 5 | 62.33±2.13 |
Claims (10)
1. skin care compositions with defying age, whitening function is characterized in that comprising by weight following component:
Semen Coicis extract 1-10 part, Radix Sangusorbae extract 1-10 part, Radix Platycodonis extract 1-10 part, Radix Et Rhizoma Rhei extract 1-10 part, Flos Caryophylli extract 0.1-10 part, Poria extract 1-10 part, red autumnal leaves algae extract 1-10 part, Fructus actinidiae chinensis extract 1-10 part and Tremella extract 1-10 part.
2. compositions according to claim 1 is characterized in that described Semen Coicis extract is that 8 parts, Radix Sangusorbae extract are that 3 parts, Radix Platycodonis extract are that 2 parts, Radix Et Rhizoma Rhei extract are that 2 parts, Flos Caryophylli extract are that 0.5 part, Poria extract are that 2 parts, red autumnal leaves algae extract are that 2 parts, Fructus actinidiae chinensis extract are that 2 parts, Tremella extract are 5 parts.
3. compositions according to claim 1 and 2 is characterized in that:
Described Semen Coicis extract is to make with following method: take Semen Coicis, adding described Semen Coicis quality 2-5 volumetric concentration doubly is the ethanol water of 1%-99.9%, put in the ultrasonic waves for cleaning instrument of 10-100kHz ultrasonic 1-5 minute, adding described Semen Coicis quality 5-10 volumetric concentration doubly is the ethanol water of 1%-99.9% again, normal heating backflow 0.5-4 hour, filter concentrated filtrate, drying;
Described Radix Sangusorbae extract is to make with following method: take Radix Sanguisorbae, adding described Radix Sanguisorbae quality 2-5 volumetric concentration doubly is the ethanol water of 1%-99.9%, put in the ultrasonic waves for cleaning instrument of 10-100kHz ultrasonic 1-5 minute, adding described Radix Sanguisorbae quality 5-10 volumetric concentration doubly is the ethanol water of 1%-99.9% again, normal heating backflow 0.5-4 hour, filter concentrated filtrate, drying;
Described Radix Platycodonis extract is to make with following method: take Radix Platycodonis, adding described Radix Platycodonis quality 2-5 volumetric concentration doubly is the ethanol water of 1%-99.9%, put in the ultrasonic waves for cleaning instrument of 10-100kHz ultrasonic 1-5 minute, adding described Radix Platycodonis quality 5-10 volumetric concentration doubly is the ethanol water of 1%-99.9% again, normal heating backflow 0.5-4 hour, filter concentrated filtrate, drying;
Described Radix Et Rhizoma Rhei extract is to make with following method: take Radix Et Rhizoma Rhei, adding described Radix Et Rhizoma Rhei quality 2-5 volumetric concentration doubly is the ethanol water of 1%-99.9%, put in the ultrasonic waves for cleaning instrument of 10-100kHz ultrasonic 1-5 minute, adding described Radix Et Rhizoma Rhei quality 5-10 volumetric concentration doubly is the ethanol water of 1%-99.9% again, normal heating backflow 0.5-4 hour, filter concentrated filtrate, drying;
Described Flos Caryophylli extract is made with following method: get the Flos Caryophylli supercritical CO
2Extraction, extracting pressure are that 5-20MPa, extraction temperature 20-50 ℃, extraction time 0.5-5 hour namely get the Flos Caryophylli extract;
Described Poria extract is to make with following method: take Poria, add described Poria quality 2-5 water doubly, put in the ultrasonic waves for cleaning instrument of 10-100kHz ultrasonic 1-5 minute, add described Poria quality 5-10 water doubly, normal heating backflow 0.5-4 hour filters again, concentrated filtrate, drying;
Described red autumnal leaves algae extract is to make with following method: take the red autumnal leaves algae, add described red autumnal leaves algae quality 2-5 water doubly, put in the ultrasonic waves for cleaning instrument of 10-100kHz ultrasonic 1-5 minute, add again described red autumnal leaves algae quality 5-10 water doubly, normal heating backflow 0.5-4 hour, filter concentrated filtrate, drying;
Described Fructus actinidiae chinensis extract is to make with following method: take Fructus actinidiae chinensis, adding described Fructus actinidiae chinensis quality 2-5 volumetric concentration doubly is the ethanol water of 1%-99.9%, put in the ultrasonic waves for cleaning instrument of 10-100kHz ultrasonic 1-5 minute, adding described Fructus actinidiae chinensis quality 5-10 volumetric concentration doubly is the ethanol water of 1%-99.9% again, normal heating backflow 0.5-4 hour, filter concentrated filtrate, drying;
Described Tremella extract is to make with following method: take Tremella, add described Tremella quality 2-5 water doubly, put in the ultrasonic waves for cleaning instrument of 10-100kHz ultrasonic 1-5 minute, add described Tremella quality 5-10 water doubly, normal heating backflow 0.5-4 hour filters again, concentrated filtrate, drying.
4. compositions according to claim 3, it is characterized in that described Semen Coicis extract is to make with following method: take Semen Coicis, the volumetric concentration that adds 3 times of described Semen Coicis quality is 75% ethanol water, put in the ultrasonic waves for cleaning instrument of 85kHz ultrasonic 4 minutes, the volumetric concentration that adds again 7 times of described Semen Coicis quality is 75% ethanol water, and normal heating refluxed 3 hours, filters, concentrated filtrate, drying.
5. compositions according to claim 3, it is characterized in that described Radix Sangusorbae extract is to make with following method: take Radix Sanguisorbae, the volumetric concentration that adds 3 times of described Radix Sanguisorbae quality is 60% ethanol water, put in the ultrasonic waves for cleaning instrument of 85kHz ultrasonic 4 minutes, the volumetric concentration that adds again 7 times of described Radix Sanguisorbae quality is 60% ethanol water, and normal heating refluxed 3 hours, filters, concentrated filtrate, drying.
6. compositions according to claim 3, it is characterized in that described Radix Platycodonis extract is to make with following method: take Radix Platycodonis, the volumetric concentration that adds 4 times of described Radix Platycodonis quality is 75% ethanol water, put in the ultrasonic waves for cleaning instrument of 85kHz ultrasonic 4 minutes, the volumetric concentration that adds again 7 times of described Radix Platycodonis quality is 75% ethanol water, and normal heating refluxed 3 hours, filters, concentrated filtrate, drying.
7. compositions according to claim 3, it is characterized in that described Radix Et Rhizoma Rhei extract is to make with following method: take Radix Et Rhizoma Rhei, the volumetric concentration that adds 4.5 times of described Radix Et Rhizoma Rhei quality is 45% ethanol water, put in the ultrasonic waves for cleaning instrument of 85kHz ultrasonic 4 minutes, the volumetric concentration that adds again 9 times of described Radix Et Rhizoma Rhei quality is 45% ethanol water, and normal heating refluxed 3 hours, filters, concentrated filtrate, drying.
8. compositions according to claim 3, it is characterized in that described Poria extract is to make with following method: take Poria, the water that adds 4 times of described Poria quality, put in the ultrasonic waves for cleaning instrument of 85kHz ultrasonic 4 minutes, the water that adds again 9 times of described Poria quality, normal heating refluxed 3 hours, filtered, concentrated filtrate, drying.
9. compositions according to claim 3, it is characterized in that described red autumnal leaves algae extract is to make with following method: take the red autumnal leaves algae, the water that adds 3 times of described red autumnal leaves algae quality, put in the ultrasonic waves for cleaning instrument of 85kHz ultrasonic 3 minutes, the water that adds again 7 times of described red autumnal leaves algae quality, normal heating refluxed 3 hours, filtered, concentrated filtrate, drying.
10. compositions according to claim 3, it is characterized in that described Fructus actinidiae chinensis extract is to make with following method: take Fructus actinidiae chinensis, the volumetric concentration that adds 3 times of described Fructus actinidiae chinensis quality is 60% ethanol water, put in the ultrasonic waves for cleaning instrument of 85kHz ultrasonic 3 minutes, the volumetric concentration that adds again 7 times of described Fructus actinidiae chinensis quality is 60% ethanol water, and normal heating refluxed 3 hours, filters, concentrated filtrate, drying; Described Tremella extract is to make with following method: take Tremella, add the water of 4 times of described Tremella quality, put in the ultrasonic waves for cleaning instrument of 85kHz ultrasonic 3 minutes, the water that adds again 9 times of described Tremella quality, normal heating refluxed 3 hours, filtered, concentrated filtrate, drying.
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| CN114146019A (en) * | 2021-12-29 | 2022-03-08 | 上海应用技术大学 | Pachyman extract and application thereof in resisting ultraviolet rays |
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| CN104434706A (en) * | 2014-12-29 | 2015-03-25 | 北京一轻研究院 | Garden burnet extract for delaying skin aging and preparation method of garden burnet extract |
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| CN105250190A (en) * | 2015-11-25 | 2016-01-20 | 山西振东家庭健康护理用品有限公司 | Traditional Chinese medicine bacteriostasis skin-care liquid soap and preparation method thereof |
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| CN108478463A (en) * | 2018-04-28 | 2018-09-04 | 广州赛莱拉干细胞科技股份有限公司 | Composition containing red autumnal leaves algae extract and its application in cosmetics |
| CN111904900A (en) * | 2020-08-19 | 2020-11-10 | 广州市科能化妆品科研有限公司 | Tyrosinase inhibitor composition, skin brightening essence and preparation method thereof |
| CN114146019A (en) * | 2021-12-29 | 2022-03-08 | 上海应用技术大学 | Pachyman extract and application thereof in resisting ultraviolet rays |
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