CN103121212B - The microrobot driven based on antibacterial - Google Patents
The microrobot driven based on antibacterial Download PDFInfo
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- CN103121212B CN103121212B CN201110367127.3A CN201110367127A CN103121212B CN 103121212 B CN103121212 B CN 103121212B CN 201110367127 A CN201110367127 A CN 201110367127A CN 103121212 B CN103121212 B CN 103121212B
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- 230000000844 anti-bacterial effect Effects 0.000 title claims 11
- 241000894006 Bacteria Species 0.000 claims abstract description 41
- 230000006698 induction Effects 0.000 claims abstract description 27
- 239000000084 colloidal system Substances 0.000 claims abstract description 21
- 230000005684 electric field Effects 0.000 claims abstract description 12
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 9
- 239000007769 metal material Substances 0.000 claims description 3
- 210000003495 flagella Anatomy 0.000 claims description 2
- 238000012258 culturing Methods 0.000 claims 6
- 238000006073 displacement reaction Methods 0.000 claims 1
- 230000001580 bacterial effect Effects 0.000 abstract description 10
- 239000000243 solution Substances 0.000 description 17
- 230000033001 locomotion Effects 0.000 description 7
- -1 hydrogen ions Chemical class 0.000 description 5
- 239000001257 hydrogen Substances 0.000 description 4
- 229910052739 hydrogen Inorganic materials 0.000 description 4
- 238000000034 method Methods 0.000 description 4
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 244000005700 microbiome Species 0.000 description 3
- 238000011160 research Methods 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- 239000012670 alkaline solution Substances 0.000 description 2
- 230000007423 decrease Effects 0.000 description 2
- 230000007547 defect Effects 0.000 description 2
- 238000011161 development Methods 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 230000026058 directional locomotion Effects 0.000 description 2
- 230000007613 environmental effect Effects 0.000 description 2
- 239000011810 insulating material Substances 0.000 description 2
- 238000006722 reduction reaction Methods 0.000 description 2
- 241000588724 Escherichia coli Species 0.000 description 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 230000035605 chemotaxis Effects 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 238000005868 electrolysis reaction Methods 0.000 description 1
- 239000008151 electrolyte solution Substances 0.000 description 1
- 230000005674 electromagnetic induction Effects 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical compound [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 238000004088 simulation Methods 0.000 description 1
- 230000004083 survival effect Effects 0.000 description 1
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- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Abstract
本发明涉及一种基于细菌驱动的微型机器人,该微型机器人置于溶液中,所述的微型机器人包括本体、感应线圈、细菌培养胶体和鞭毛细菌,所述的鞭毛细菌固定在细菌培养胶体,所述的细菌培养胶体、感应线圈固定在本体上,所述的感应线圈处于交变电场中;施加交变电场后感应线圈中产生电流,溶液电解,产生pH梯度场推动鞭毛细菌定向移动,鞭毛细菌推动本体移动。与现有技术相比,本发明具有结构简单、易于实现、动力充足稳定等优点。
The present invention relates to a microrobot driven by bacteria. The microrobot is placed in a solution. The microrobot includes a body, an induction coil, a bacterial culture colloid and flagellate bacteria. The flagellate bacteria are fixed on the bacterial culture colloid. The bacterial culture colloid and the induction coil are fixed on the body, and the induction coil is in an alternating electric field; after the alternating electric field is applied, an electric current is generated in the induction coil, the solution is electrolyzed, and a pH gradient field is generated to push the flagellar bacteria to move directionally, and the flagellar bacteria Push the body to move. Compared with the prior art, the present invention has the advantages of simple structure, easy realization, sufficient and stable power and the like.
Description
技术领域 technical field
本发明涉及一种机器人,尤其是涉及一种基于细菌驱动的微型机器人。The invention relates to a robot, in particular to a micro-robot driven by bacteria.
背景技术 Background technique
近几年来,国内外对于机器人的驱动方式进行了大量研究,新型驱动原理对于扩充人类的活动范围非常重要,利用生物能量,特别是微型生物能量的探索才刚刚开始。利用微型生物的能量,通过控制微型生物运动从而带动机器人运动时一个新的研究领域。In recent years, a lot of research has been done on the driving methods of robots at home and abroad. New driving principles are very important for expanding the range of human activities. The exploration of using bio-energy, especially micro-bio-energy, has just begun. Using the energy of micro organisms to control the motion of micro organisms to drive the movement of robots is a new research field.
能量供给是微型机器人微型化设计中的关键及主要挑战,利用细菌等生物的能量作为微型机器人的能量驱动是一个非常有效地尝试。研究细菌在液体中依附于微型机器人并推动机器人运动的环境模拟与试验技术等能促进对细菌运动控制的使用并推动机器人在医疗卫生、环境以及化学等行业的发展,由于纳米技术的发展,这种具有低成本的微型机器人具有非常实用的前景。但是目前的微生物驱动的微型机器人普遍存在动力不足、状态不稳定等缺陷。Energy supply is the key and main challenge in the miniaturization design of micro-robots. It is a very effective attempt to use the energy of bacteria and other organisms as the energy drive of micro-robots. Research on environmental simulation and experimental technology that bacteria attach to micro-robots in liquid and promote robot movement can promote the use of bacterial movement control and promote the development of robots in medical, environmental and chemical industries. Due to the development of nanotechnology, this A low-cost microrobot has very practical prospects. However, the current micro-robots driven by microorganisms generally have defects such as insufficient power and unstable state.
发明内容 Contents of the invention
本发明的目的就是为了克服上述现有技术存在的缺陷而提供一种结构简单、易于实现、动力充足稳定的基于细菌驱动的微型机器人。The object of the present invention is to provide a bacteria-driven micro-robot with simple structure, easy implementation, sufficient and stable power, in order to overcome the above-mentioned defects in the prior art.
本发明的目的可以通过以下技术方案来实现:The purpose of the present invention can be achieved through the following technical solutions:
一种基于细菌驱动的微型机器人,其特征在于,该微型机器人置于溶液中,所述的微型机器人包括本体、感应线圈、细菌培养胶体和鞭毛细菌,所述的鞭毛细菌固定在细菌培养胶体,所述的细菌培养胶体、感应线圈固定在本体上,所述的感应线圈处于交变电场中;A micro-robot driven by bacteria is characterized in that the micro-robot is placed in a solution, and the micro-robot includes a body, an induction coil, a bacterial culture colloid and flagellate bacteria, and the flagellate bacteria are fixed on the bacterial culture colloid, The bacterial culture colloid and the induction coil are fixed on the body, and the induction coil is in an alternating electric field;
施加交变电场后感应线圈中产生电流,溶液电解,产生pH梯度场推动鞭毛细菌定向移动,鞭毛细菌推动本体移动。After an alternating electric field is applied, a current is generated in the induction coil, the solution is electrolyzed, and a pH gradient field is generated to push the directional movement of the flagellar bacteria, and the flagellar bacteria push the body to move.
所述的本体的直径为200~800μm。The diameter of the body is 200-800 μm.
所述的本体和细菌培养胶体均由绝缘材料加工而成,细菌培养胶体位于本体后部。Both the body and the bacteria culture colloid are processed from insulating materials, and the bacteria culture colloid is located at the rear of the body.
所述的感应线圈固定于本体的上方或下方,且浸没在溶液中。The induction coil is fixed above or below the main body and immersed in the solution.
所述的溶液为带有氢氧根的碱性溶液。The solution is an alkaline solution with hydroxide.
所述的溶液为氢氧化钠溶液。Described solution is sodium hydroxide solution.
所述的感应线圈的直径为20~50μm,所述的感应线圈构成闭合回路。The diameter of the induction coil is 20-50 μm, and the induction coil forms a closed loop.
所述的感应线圈采用惰性金属材料。The induction coil is made of inert metal material.
所述的鞭毛细菌同向、有序地排列于细菌培养胶体上,所述的鞭毛细菌的鞭毛位于本体的末端。The flagellated bacteria are arranged in the same direction and orderly on the bacterial culture colloid, and the flagella of the flagellated bacteria are located at the end of the body.
与现有技术相比,本发明具有结构简单、配合外加交变电场、可在溶液中运动、加工方便、易于实现、动力充足稳定。Compared with the prior art, the present invention has the advantages of simple structure, matching with an external alternating electric field, movement in solution, convenient processing, easy realization, sufficient and stable power.
附图说明 Description of drawings
图1为本发明的主视结构示意图;Fig. 1 is the front view structure schematic diagram of the present invention;
图2为本发明的立体结构示意图。Fig. 2 is a schematic diagram of the three-dimensional structure of the present invention.
具体实施方式 detailed description
下面结合附图和具体实施例对本发明进行详细说明。The present invention will be described in detail below in conjunction with the accompanying drawings and specific embodiments.
实施例Example
如图1、图2所示,一种基于细菌驱动的微型机器人,该微型机器人置于溶液中,所述的微型机器人包括本体1、感应线圈2、细菌培养胶体3和鞭毛细菌4,所述的鞭毛细菌4固定在细菌培养胶体3,所述的细菌培养胶体3、感应线圈2固定在本体1上,所述的感应线圈2处于交变电场中;施加交变电场后感应线圈2中电流电解溶液,产生pH梯度场推动鞭毛细菌4定向移动,鞭毛细菌4推动本体移动。As shown in Figure 1 and Figure 2, a microrobot driven by bacteria is placed in a solution, and the microrobot includes a body 1, an induction coil 2, a bacterial culture colloid 3 and a flagellate bacterium 4, and the microrobot is placed in a solution. The flagellar bacteria 4 are fixed on the bacteria culture colloid 3, the bacteria culture colloid 3 and the induction coil 2 are fixed on the body 1, and the induction coil 2 is in the alternating electric field; the current in the induction coil 2 is applied after the alternating electric field The electrolytic solution generates a pH gradient field to push the directional movement of the flagellated bacteria 4, and the flagellated bacteria 4 pushes the body to move.
(1)微型机器人置于溶液中(1) The microrobot is placed in the solution
溶液必须可电解产生氢离子,感应线圈浸没于溶液中,溶液可选择氢氧化钠、氢氧化钾等带有氢氧根的碱性溶液。The solution must be able to generate hydrogen ions by electrolysis, and the induction coil is immersed in the solution. The solution can be an alkaline solution with hydroxide radicals such as sodium hydroxide and potassium hydroxide.
(2)、感应线圈采用铂丝(2), the induction coil adopts platinum wire
要求线圈不发生物理、化学变化,具有点化学稳定性,因此采用惰性金属材料。It is required that the coil does not undergo physical and chemical changes, and has a little chemical stability, so an inert metal material is used.
(3)、外加交变电场覆盖溶液所在区域(3) Apply an alternating electric field to cover the area where the solution is located
基于电磁感应原理,外加交变电场使感应线圈中产生感应电流,金属丝中形成电流回路。基于电化学原理,电极过程启动,线圈周围溶液被电解,电解溶液的过程中,发生氧化反应的区域产氢离子和氧气,发生还原反应的区域产生氢氧根离子和氢气。因此氢离子浓度升高后,pH值减小,同理,还原反应处氢离子浓度降低,pH值增大。产生pH梯度场。Based on the principle of electromagnetic induction, an alternating electric field is applied to generate an induced current in the induction coil, and a current loop is formed in the metal wire. Based on the electrochemical principle, the electrode process is started, and the solution around the coil is electrolyzed. During the process of electrolyzing the solution, hydrogen ions and oxygen are produced in the area where the oxidation reaction occurs, and hydroxide ions and hydrogen gas are produced in the area where the reduction reaction occurs. Therefore, when the concentration of hydrogen ions increases, the pH value decreases. Similarly, the concentration of hydrogen ions at the reduction reaction decreases and the pH value increases. Generates a pH gradient field.
(4)、微型机器人运动(4), micro robot movement
由于趋药性,在pH梯度场中鞭毛细菌自发地向适合生存的pH值区域作趋化运动,因其固定在微型机器人的细菌培养胶体上,便推动机器人运动。Due to chemotaxis, flagellar bacteria spontaneously move towards the pH value region suitable for survival in the pH gradient field, and because they are fixed on the bacterial culture colloid of the micro-robot, they push the robot to move.
(5)、微型机器人控制(5), micro robot control
改变外加交变电场的频率、幅值及电场方向,即可控制细菌及微型机器人的运动速度、方向。By changing the frequency, amplitude and direction of the applied alternating electric field, the movement speed and direction of bacteria and micro-robots can be controlled.
由于细菌的微观尺寸,需选用轻质绝缘材料制作微型机器人本体及培养胶体;在胶体上培养细胞和细菌,是组织工程学上的成熟技术;由于细菌生存条件限制,实验过程中需注意温度、pH值等的影响;交变电压幅值不可过大,根据实验经验,感应电动势不宜超过3.0V,否则会使细菌失去活性;细菌特性对机器人影响极大,应选择活性高、pH浓度敏感的细菌进行培养,如大肠杆菌;细菌密度不可过大,否则细菌会相互缠绕在一起,失去动力。Due to the microscopic size of bacteria, it is necessary to use lightweight insulating materials to make the micro-robot body and culture colloids; cultivating cells and bacteria on colloids is a mature technology in tissue engineering; due to the limited living conditions of bacteria, attention should be paid to temperature, The influence of pH value, etc.; the amplitude of the alternating voltage should not be too large. According to the experimental experience, the induced electromotive force should not exceed 3.0V, otherwise the bacteria will lose their activity; the characteristics of bacteria have a great impact on the robot, and the one with high activity and pH sensitivity should be selected. Bacteria are cultivated, such as E. coli; the density of bacteria should not be too large, otherwise the bacteria will entangle with each other and lose power.
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CN115181665B (en) * | 2022-07-11 | 2025-01-21 | 苏州欧奇普系统科技有限公司 | A human organ chip microfluidic system and implementation method |
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