CN103110572A - Gynecological antimicrobial gel recipe and preparation method thereof - Google Patents
Gynecological antimicrobial gel recipe and preparation method thereof Download PDFInfo
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- CN103110572A CN103110572A CN2012105563210A CN201210556321A CN103110572A CN 103110572 A CN103110572 A CN 103110572A CN 2012105563210 A CN2012105563210 A CN 2012105563210A CN 201210556321 A CN201210556321 A CN 201210556321A CN 103110572 A CN103110572 A CN 103110572A
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- chitosan
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- purified water
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- 238000002360 preparation method Methods 0.000 title claims abstract description 14
- 230000000845 anti-microbial effect Effects 0.000 title abstract 2
- 229920001661 Chitosan Polymers 0.000 claims abstract description 47
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 40
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims abstract description 26
- 239000011630 iodine Substances 0.000 claims abstract description 24
- 229910052740 iodine Inorganic materials 0.000 claims abstract description 24
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 23
- 239000008213 purified water Substances 0.000 claims abstract description 19
- 239000002994 raw material Substances 0.000 claims abstract description 17
- JLKDVMWYMMLWTI-UHFFFAOYSA-M potassium iodate Chemical compound [K+].[O-]I(=O)=O JLKDVMWYMMLWTI-UHFFFAOYSA-M 0.000 claims abstract description 15
- 239000001230 potassium iodate Substances 0.000 claims abstract description 15
- 229940093930 potassium iodate Drugs 0.000 claims abstract description 15
- 235000006666 potassium iodate Nutrition 0.000 claims abstract description 15
- 238000003756 stirring Methods 0.000 claims abstract description 15
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 claims abstract description 13
- 239000004354 Hydroxyethyl cellulose Substances 0.000 claims abstract description 13
- 229920001213 Polysorbate 20 Polymers 0.000 claims abstract description 13
- 229960000583 acetic acid Drugs 0.000 claims abstract description 13
- 239000012362 glacial acetic acid Substances 0.000 claims abstract description 13
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 claims abstract description 13
- 239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 claims abstract description 13
- 235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 claims abstract description 13
- 229940071826 hydroxyethyl cellulose Drugs 0.000 claims abstract description 12
- 238000005303 weighing Methods 0.000 claims abstract description 6
- 239000000463 material Substances 0.000 claims abstract description 4
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 claims description 22
- 230000003115 biocidal effect Effects 0.000 claims description 21
- PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical compound II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 claims description 10
- 238000000034 method Methods 0.000 claims description 3
- 238000000746 purification Methods 0.000 claims description 3
- 238000010668 complexation reaction Methods 0.000 claims description 2
- 239000012467 final product Substances 0.000 claims description 2
- 230000000694 effects Effects 0.000 abstract description 7
- 230000001954 sterilising effect Effects 0.000 abstract description 6
- 238000004659 sterilization and disinfection Methods 0.000 abstract description 6
- 206010046914 Vaginal infection Diseases 0.000 abstract description 4
- 201000008100 Vaginitis Diseases 0.000 abstract description 2
- 230000008901 benefit Effects 0.000 abstract description 2
- 206010008323 cervicitis Diseases 0.000 abstract description 2
- 201000003988 chronic cervicitis Diseases 0.000 abstract description 2
- 235000011187 glycerol Nutrition 0.000 abstract 2
- 229940068977 polysorbate 20 Drugs 0.000 abstract 2
- 239000004480 active ingredient Substances 0.000 abstract 1
- 229940045110 chitosan Drugs 0.000 abstract 1
- 229960005150 glycerol Drugs 0.000 abstract 1
- 230000000844 anti-bacterial effect Effects 0.000 description 8
- 239000000047 product Substances 0.000 description 5
- CPKVUHPKYQGHMW-UHFFFAOYSA-N 1-ethenylpyrrolidin-2-one;molecular iodine Chemical class II.C=CN1CCCC1=O CPKVUHPKYQGHMW-UHFFFAOYSA-N 0.000 description 4
- 239000000693 micelle Substances 0.000 description 3
- 241000894006 Bacteria Species 0.000 description 2
- 229920000153 Povidone-iodine Polymers 0.000 description 2
- 239000000645 desinfectant Substances 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 238000001879 gelation Methods 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 210000004877 mucosa Anatomy 0.000 description 2
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 2
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 2
- 229960001621 povidone-iodine Drugs 0.000 description 2
- 239000004094 surface-active agent Substances 0.000 description 2
- 241000304886 Bacilli Species 0.000 description 1
- 244000063299 Bacillus subtilis Species 0.000 description 1
- 235000014469 Bacillus subtilis Nutrition 0.000 description 1
- GAWIXWVDTYZWAW-UHFFFAOYSA-N C[CH]O Chemical group C[CH]O GAWIXWVDTYZWAW-UHFFFAOYSA-N 0.000 description 1
- 241000222122 Candida albicans Species 0.000 description 1
- 241000588724 Escherichia coli Species 0.000 description 1
- 241000192125 Firmicutes Species 0.000 description 1
- 241000233866 Fungi Species 0.000 description 1
- 241000187479 Mycobacterium tuberculosis Species 0.000 description 1
- 241000588652 Neisseria gonorrhoeae Species 0.000 description 1
- 241000589517 Pseudomonas aeruginosa Species 0.000 description 1
- 241000191967 Staphylococcus aureus Species 0.000 description 1
- 241000191963 Staphylococcus epidermidis Species 0.000 description 1
- 241000194017 Streptococcus Species 0.000 description 1
- 241000223238 Trichophyton Species 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 230000000259 anti-tumor effect Effects 0.000 description 1
- 239000013011 aqueous formulation Substances 0.000 description 1
- 230000004071 biological effect Effects 0.000 description 1
- 229940095731 candida albicans Drugs 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 230000006196 deacetylation Effects 0.000 description 1
- 238000003381 deacetylation reaction Methods 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 238000004821 distillation Methods 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 230000003628 erosive effect Effects 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 230000009931 harmful effect Effects 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 230000002949 hemolytic effect Effects 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 239000002085 irritant Substances 0.000 description 1
- 231100000021 irritant Toxicity 0.000 description 1
- 230000002147 killing effect Effects 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 229920002521 macromolecule Polymers 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 231100000957 no side effect Toxicity 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 229920000620 organic polymer Polymers 0.000 description 1
- 210000002640 perineum Anatomy 0.000 description 1
- -1 plays solubilization Substances 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 230000008439 repair process Effects 0.000 description 1
- 230000007928 solubilization Effects 0.000 description 1
- 238000005063 solubilization Methods 0.000 description 1
- 230000003381 solubilizing effect Effects 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 210000001215 vagina Anatomy 0.000 description 1
- 230000029663 wound healing Effects 0.000 description 1
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention discloses a gynecological antimicrobial gel recipe and a preparation method thereof. A gel takes chitosan-iodine as a main active ingredient and comprises raw materials of chitosan-iodine, glacial acetic acid, polysorbate-20, glycerin, potassium iodate, chitosan, hydroxyethyl cellulose and purified water. The preparation method comprises the following steps of: (1) weighing according to the recipe for standby; (2) adding the glacial acetic acid, the polysorbate-20, the glycerin and part of the purified water into the chitosan-iodine to be fully and uniformly mixed, and completely dissolving for standby; (3) taking a small amount of purified water to dissolve the potassium iodate, adding the dissolved potassium iodate into standby materials to be mixed, and stirring uniformly; (4) adding the chitosan according to the raw material mass ratio, and stirring to dissolve the chitosan; and (5) adding the hydroxyethyl cellulose according to the raw material mass ratio, adding the residual purified water to 100% and slowly stirring to form the gel. The gel has the advantages of good stability, excellent sterilization effect and convenience in use; and the processed gel can be used for treating colpitis mycotica, mixed vaginitis and the like as well as chronic cervicitis.
Description
Technical field
The present invention relates to medical dressing, particularly contain the dressing of chitosan iodine, specifically, relate to gynaecologic antibiotic gel.
Background technology
Iodine is used for the body sterilization history of existing 150 years, but the dissolubility in water is very little due to iodine, only has 1.315 * 10 under 25 ℃
-3Mol/L, can not be made into aqueous formulation and use, at room temperature easily distillation, content are unstable, to the mucocutaneous shortcoming such as irritant, have limited its extensive use.At present, widely used povidone iodine class disinfectant is take organic polymer or surfactant as carrier mostly, by network structure or the micelle that forms between carrier molecule, with the conformational effect in electronics and space with iodine " constraint " in wherein, thereby change the free state of iodine in general Operand, make its stability and bactericidal action enhancing, zest and xanthochromia reduction.But original micelle power can be destroyed after dilution for the finished product of this class take surfactant as carrier, makes the stability decreases of active iodine, thereby affect its sterilization effect.At present, most widely used povidone iodine class disinfectant is the povidone iodine complex in China, is recorded in version " two ones of Chinese pharmacopoeia in 2010.But polyvidone is less to the dissolubility of iodine, and molecular weight large (can up to 70000), more difficult being biodegradable, and life-time service can produce harmful effect to environment.In addition, itself there is no bactericidal action polyvidone, just forms micelle as a kind of surface activity carrier, improves the stability of iodine molecule.
Chitosan (chitosan) is the unique positively charged side chain polysaccharide of occurring in nature, has antibioticly, and antitumor strengthens the functions such as immunity, has good biocompatibility, and nonirritant, has no side effect, due to 2-NH
2Existence, chitosan has certain bacteria resistance function, but bacteriostasis property is limited, and is subject to the impact of the conditions such as chitosan molecule amount, deacetylation.Chitosan is a kind of macromolecular compound of biological property excellence, and after absorption iodine, the heat stability of iodine improves greatly, and is the same with other povidone iodine, and shell iodine can discharge elemental iodine, thereby has strong sterilization.This finished product is nontoxic, good stability, nonirritant.Bibliographical information has been arranged the sterilization effect of chitosan iodine (" laboratory observation of chitosan iodine liquid bactericidal effect ", Hengyang Medical College's journal (medicine) 05 phase in 2000), its chitosan raw material used is water-soluble chitosan.
In Chinese patent database, relate to the patent application of chitosan making gynaecologic antibiotic gel preparation few, No. 201010563054.0 " a kind of gel preparation and preparation technologies thereof that are used for the treatment of the gynaecopathias such as cervical erosion ", No. 201110031716.4 " a kind of washing-free puerpera perineum medical-care gel and preparation method thereof ", No. 201210135254.5 " Chitosangynaecologicsuppository antibacterial gel and preparation method thereof " are only arranged, but there is no the patent application of making the gynaecologic antibiotic gel preparation of chitosan iodine.
Summary of the invention
The purpose of this invention is to provide a kind of good stability, the gynaecologic antibiotic gel formula that bactericidal effect is good makes it the health service into the mankind.
Another purpose of the present invention is to provide the preparation method of above-mentioned gynaecologic antibiotic gel, enables to realize clinical practical application.
The gynaecologic antibiotic gel that the inventor provides, take chitosan iodine as main active, its raw materials quality formula is as follows:
Chitosan iodine 0.2%～5%
Glacial acetic acid 0.1%～2.5%
Tween-20 0.6%～15%
Glycerol 0.5%～12.5%
Potassium iodate 0.005%～0.125%
Chitosan 0.3%～2.4%
Hydroxyethyl-cellulose 1.5%～6.5%
Purified water adds to 100%.
The raw material preferred mass formula of above-mentioned gynaecologic antibiotic gel is as follows:
Chitosan iodine 2%
Glacial acetic acid 0.5%
Tween-20 3%
Glycerol 2.5%
Potassium iodate 0.025%
Chitosan 0.5%
Hydroxyethyl-cellulose 2.25%
Purified water adds to 100%.
Above-mentioned chitosan iodine is that water-insoluble chitosan and iodine get through complexation reaction preparation.
Above-mentioned Polysorbate-2, glycerol, potassium iodate, hydroxy ethyl fiber, purified water all meet the requirement of the Pharmacopoeia of the People's Republic of China.
The preparation method of the gynaecologic antibiotic gel that the inventor provides comprises the following steps:
1. according to the weighing of raw materials quality formula, standby;
2. add glacial acetic acid, Tween-20, glycerol, partial purification water to stir in chitosan iodine, make dissolving fully, standby;
3. the purified water that takes a morsel dissolving potassium iodate, and join in standby material and mix, stir;
4. add chitosan according to the raw materials quality formula, stir and make the chitosan dissolving;
5. add hydroxyethyl-cellulose according to the raw materials quality formula, and add to 100% with remaining purified water, slowly stir and make into gel, and get final product.
The inventor points out: the chitosan iodine in gynaecologic antibiotic gel mainly plays effect antibiotic and the promotion wound healing, glacial acetic acid is used for regulating pH value, and play collaborative solubilizing effect, Tween-20 mainly plays solubilization, glycerol plays blending and moisture-keeping function, potassium iodate plays stabilizer function, and chitosan and hydroxyethyl-cellulose have been all the effects that increases viscosity, and purified water is diluent.Gynaecologic antibiotic gel has the high-efficiency broad spectrum bactericidal action, to gram positive bacterias such as staphylococcus aureus, staphylococcus epidermidis, beta hemolytic streptococcus, bacillus subtilises, to gram negative bacterias such as escherichia coli, Pseudomonas aeruginosa, Diplococcus gonorrhoeae, to funguses such as Candida albicans, acrothesium floccosum, trichophyton, to acid-fast bacillis such as mycobacterium tuberculosis, infusorian etc. all there is extremely strong killing action.
The gynaecologic antibiotic gel that the inventor provides has good biocompatibility, to the vaginal mucosa nonirritant, and has stronger adhesiveness, and after the injection vagina, the energy secure adhesion in vaginal wall, slowly discharges sterilization component; Wherein contained constituent of chitosan has repair to the vaginal mucosa of damage.
Gynaecologic antibiotic gel of the present invention has good stability, and the advantage that bactericidal effect is good, easy to use can be used for treating colpitis mycotica due to the cause pathogeny imcrobe infections such as antibacterial, mycete, infusorian, Combination vaginitis etc. and chronic cervicitis after processing.
The specific embodiment
Describe the specific embodiment of the present invention in detail by the following example
EXAMPLE lAccording to the weighing of following raw materials according quality formula: chitosan iodine 0.2g, glacial acetic acid 0.1g, Tween-20 0.6g, glycerol 0.5g, potassium iodate 0.005g, chitosan 0.8g, hydroxyethyl-cellulose 2.4g adds purified water to 100g.Add glacial acetic acid, Tween-20, glycerol, partial purification water to stir in chitosan iodine, make dissolving fully, standby; The purified water that takes a morsel afterwards dissolving potassium iodate, and join in standby material and mix, stir; Add again the recipe quantity chitosan, stir and make the chitosan dissolving; Add at last the recipe quantity hydroxyethyl-cellulose, add remaining purified water to 100g, slowly stir and make into gel, namely get the gynaecologic antibiotic gel finished product.
Embodiment 2According to the weighing of following raw materials according quality formula: chitosan iodine 2g, glacial acetic acid 0.5 g, Tween-20 3g, glycerol 2.5g, potassium iodate 0.025g, chitosan 0.5g, hydroxyethyl-cellulose 2.25g adds purified water to 100g.Method for making obtains the gynaecologic antibiotic gel finished product with embodiment 1.
Embodiment 3According to the weighing of following raw materials according quality formula: chitosan iodine 5g, glacial acetic acid 2.5 g, Tween-20 15g, glycerol 12.5g, potassium iodate 0.125g, chitosan 2.4g, hydroxyethyl-cellulose 6.5g, purified water adds to 100g.Method for making obtains the gynaecologic antibiotic gel finished product with embodiment 1.
Claims (4)
1. a gynaecologic antibiotic gel, is characterized in that it take chitosan iodine as main active, and its raw materials quality formula is as follows:
Chitosan iodine 0.2%～5%
Glacial acetic acid 0.1%～2.5%
Tween-20 0.6%～15%
Glycerol 0.5%～12.5%
Potassium iodate 0.005%～0.125%
Chitosan 0.3%～2.4%
Hydroxyethyl-cellulose 1.5%～6.5%
Purified water adds to 100%.
2. gynaecologic antibiotic gel as claimed in claim 1 is characterized in that the raw materials quality formula of this gel is as follows:
Chitosan iodine 2%
Glacial acetic acid 0.5%
Tween-20 3%
Glycerol 2.5%
Potassium iodate 0.025%
Chitosan 0.5%
Hydroxyethyl-cellulose 2.25%
Purified water adds to 100%.
3. gynaecologic antibiotic gel as described in one of claim 1 or 2, is characterized in that described chitosan iodine is that water-insoluble chitosan and iodine get through complexation reaction preparation.
4. the method for preparing one of claim 1 or 2 described gynaecologic antibiotic gel, its feature comprises the following steps:
1. according to the weighing of raw materials quality formula, standby;
2. add glacial acetic acid, Tween-20, glycerol, partial purification water to stir in chitosan iodine, make dissolving fully, standby;
3. the purified water that takes a morsel dissolving potassium iodate, and join in standby material and mix, stir;
4. add chitosan according to the raw materials quality formula, stir and make the chitosan dissolving;
5. add hydroxyethyl-cellulose according to the raw materials quality formula, and add to 100% with remaining purified water, slowly stir and make into gel, and get final product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210556321.0A CN103110572B (en) | 2012-12-20 | 2012-12-20 | Gynecological antimicrobial gel recipe and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210556321.0A CN103110572B (en) | 2012-12-20 | 2012-12-20 | Gynecological antimicrobial gel recipe and preparation method thereof |
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| Publication Number | Publication Date |
|---|---|
| CN103110572A true CN103110572A (en) | 2013-05-22 |
| CN103110572B CN103110572B (en) | 2014-07-16 |
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| CN201210556321.0A Active CN103110572B (en) | 2012-12-20 | 2012-12-20 | Gynecological antimicrobial gel recipe and preparation method thereof |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103405382A (en) * | 2013-08-15 | 2013-11-27 | 成都益贝乐医疗器械有限公司 | Formula and preparation technology of chitosan-iodine suppository |
| CN103705535A (en) * | 2013-12-27 | 2014-04-09 | 王东宇 | Gynecological chitosan gel and preparation method thereof |
| CN105687233A (en) * | 2014-11-26 | 2016-06-22 | 天津博克尼科技发展有限公司 | Method for producing coco trimethyl ammonium chloride iodine complex gel |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102144988A (en) * | 2011-03-16 | 2011-08-10 | 贵州扬生医用器材有限公司 | Chitosan cervix uteri anti-microbial membrane and preparation method thereof |
| CN102764447A (en) * | 2012-07-27 | 2012-11-07 | 武汉人福医疗用品有限公司 | Hydrogel dressing and preparation process thereof |
-
2012
- 2012-12-20 CN CN201210556321.0A patent/CN103110572B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102144988A (en) * | 2011-03-16 | 2011-08-10 | 贵州扬生医用器材有限公司 | Chitosan cervix uteri anti-microbial membrane and preparation method thereof |
| CN102764447A (en) * | 2012-07-27 | 2012-11-07 | 武汉人福医疗用品有限公司 | Hydrogel dressing and preparation process thereof |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103405382A (en) * | 2013-08-15 | 2013-11-27 | 成都益贝乐医疗器械有限公司 | Formula and preparation technology of chitosan-iodine suppository |
| CN103705535A (en) * | 2013-12-27 | 2014-04-09 | 王东宇 | Gynecological chitosan gel and preparation method thereof |
| CN105687233A (en) * | 2014-11-26 | 2016-06-22 | 天津博克尼科技发展有限公司 | Method for producing coco trimethyl ammonium chloride iodine complex gel |
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| Publication number | Publication date |
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| CN103110572B (en) | 2014-07-16 |
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Date of cancellation: 20190918 Granted publication date: 20140716 Pledgee: Guizhou Tianxin Company limited by guarantee Pledgor: Guizhou Yangsheng Medical Instrument Co., Ltd. Registration number: 2018520000009 |
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Denomination of invention: Gynecological antimicrobial gel recipe and preparation method thereof Effective date of registration: 20191212 Granted publication date: 20140716 Pledgee: Bank of Guiyang, Limited by Share Ltd directly under the sub branch Pledgor: Guizhou Yangsheng Medical Instrument Co., Ltd. Registration number: Y2019520000014 |
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