CN103083751B - A kind of method for building up of insulin pump foundation infusion model - Google Patents
A kind of method for building up of insulin pump foundation infusion model Download PDFInfo
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- CN103083751B CN103083751B CN201310027282.XA CN201310027282A CN103083751B CN 103083751 B CN103083751 B CN 103083751B CN 201310027282 A CN201310027282 A CN 201310027282A CN 103083751 B CN103083751 B CN 103083751B
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- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 title claims abstract description 124
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- 238000001802 infusion Methods 0.000 title claims abstract description 47
- 238000000034 method Methods 0.000 title claims abstract description 13
- 230000028327 secretion Effects 0.000 claims abstract description 5
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 13
- 239000008103 glucose Substances 0.000 claims description 13
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- 102000016261 Long-Acting Insulin Human genes 0.000 description 2
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- LEMUFSYUPGXXCM-JNEQYSBXSA-N caninsulin Chemical compound [Zn].C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@H]1CSSC[C@H]2C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@H](C(N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3C=CC(O)=CC=3)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC3N=CN=C3)NC(=O)[C@H](CO)NC(=O)CNC1=O)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)O)C(O)=O)C(=O)N[C@@H](CC(N)=O)C(O)=O)=O)CSSC[C@@H](C(N2)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)CN)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](N)CC=1C=CC=CC=1)C(C)C)C1C=NC=N1 LEMUFSYUPGXXCM-JNEQYSBXSA-N 0.000 description 2
- 206010012601 diabetes mellitus Diseases 0.000 description 2
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- Infusion, Injection, And Reservoir Apparatuses (AREA)
Abstract
The present invention provides the method for building up of a kind of insulin pump foundation infusion model, solves existing insulin pump because needing the input quantity of different time sections in inputting 24 hours, the problem that its operation is complicated.The method for building up of a kind of insulin pump foundation infusion model, comprises the following steps: for according to substantial amounts of clinical data, set up the step of foundation rate infusion model；For foundation rate infusion model being stored the step in insulin pump storage device；For the signal inputted according to insulin pump input unit, by the step controlling device selection foundation rate infusion model；For according to the insulin-type inputted by input unit, basis daily amount and the foundation rate infusion model of selection, control device controlling insulin pump transmission propulsion unit and carry out the step of infusion of insulin.The present invention is according to mass data analysis, it is established that the Mathematical Modeling of conventional foundation rate, more conforms to pancreas basic crack secretion characteristic.
Description
Technical field
The present invention relates to pump transfusion means for insulin, particularly to the method for building up of a kind of insulin pump foundation infusion model.
Background technology
Diabetes are a kind of chronic diseases endangering society's population health, and its extent of injury is ranked in all diseases at present
3rd, and continuing raising.The fluctuation range controlling blood sugar can prevent and treat various severe complication, generally acknowledges now injection pancreas
Island element is to control the mode that blood sugar is maximally efficient.Owing to human body shows as lasting basic crack and phase after the meal to the demand of insulin
To heavy dose of two kinds of forms.Traditional injection system is that manual injection, i.e. clinician or patient manually inject, every day one
Secondary long-acting or Ultrolente Insulin is injected, and for meeting the human body basic demand to insulin, carries out fugitive in addition before the meal every time
Or Semilente Insulin injection, then it is the needs in order to meet Postprandial glucose control.Up-to-date mode is program control type insulin pump
Insulin injection, its dosage can be controlled by computer program with the relation of time, can inject continuously, be administered more rationally,
Effect is more preferable.
No matter select manual injection's mode or program control injection system, be by virtue of experience to calculate insulin injection amount, the most entirely
The consumption of each period insulin be can accurately be given, because habits and customs, the residence time difference, insulin kind, individual difference selected
Different impact is bigger, it is impossible to have a basic crack model to fully meet all people.
Summary of the invention
The present invention provides the method for building up of a kind of insulin pump foundation infusion model, solves existing insulin pump because of needs
The input quantity of different time sections in inputting 24 hours, the problem that its operation is complicated.
The technical scheme is that such realization: the method for building up of a kind of insulin pump foundation infusion model, including
Following steps:
For according to substantial amounts of clinical data, setting up the step of foundation rate infusion model；
For foundation rate infusion model being stored the step in insulin pump storage device；
For the signal inputted according to insulin pump input unit, by the step of control device selection foundation rate infusion model:
Insulin-type, basis daily amount and the foundation rate infusion model of selection inputted by input unit for basis, by
Control device control insulin pump transmission propulsion unit and carry out the step of infusion of insulin.The signal of insulin pump input unit input
For: the infusion of insulin information of input unit input, input unit it is converted into signal and passes to control device.
Wherein, described foundation rate infusion model of setting up comprises the following steps:
(1) select at least two by the crowd of physiological property classification, carry out dynamic glucose test for each class crowd, and
The foundation rate change curve diagram data of its correspondence is set up for all types of experimental subjects；
(2) comprehensive all of curve diagram data, can sum up the change curve data of the amount of insulin of one day pancreatic secretion
Figure, this step is according to all of curve map, simulates the change curve datagram of an amount of insulin；
(3) being a time period with half an hour, datagram improvement becomes the time period accounts for the percentage of basis daily amount,
Obtain foundation rate infusion model.
Wherein it is preferred to, the method for building up of described insulin pump foundation infusion model also includes: for according to by insulin
The signal of pump input unit input, controls device and adjusts the step of foundation rate certain time period infusion amount of infusion model.Insulin pump
The signal of input unit input is: the infusion of insulin information of input unit input, input unit be converted into signal and pass to control
Device processed.
Wherein it is preferred to, the method for building up of described insulin pump foundation infusion model also includes: for according to by insulin
The blood glucose value fluctuation of pump input unit input and the time of correcting range, control the step of device correction foundation rate.
Wherein it is preferred to, also include, for the daily schedule relatively positive quantity according to input, being adjusted day part base by controlling device
The step of plinth amount.
The method have the advantages that
1. the present invention is according to mass data analysis, it is established that the Mathematical Modeling of conventional foundation rate, more conforms to pancreas basic crack and divides
Secrete characteristic.Different users can select different models, decreases insulin pump user and arranges each time period basic crack
Blindness, and it is not required to the infusion amount being respectively provided with in 24 time periods again, it is easy and simple to handle.
2., if as the external world or the reason of self, there is fluctuation, can adjust the infusion amount of certain time period in blood glucose value,
The application making foundation rate infusion model is more flexible.
3. the people that pair individual difference is bigger, can input actually measured blood glucose value and target blood glucose value or to directly input blood sugar inclined
Difference, by the foundation rate that algorithm correction is original, makes actual blood glucose value infinite approach target blood glucose value, instructs insulin pump user
Set foundation rate.
4. add daily schedule correction to be conducive to controlling " dawn and dusk " the most rambunctious phenomenon in diabetes patient.
Accompanying drawing explanation
Fig. 1 is the change curve datagram of the amount of insulin of pancreatic secretion；
Fig. 2 is insulin pump basal rate infusion model；
Fig. 3 is that insulin pump LCDs foundation rate infusion Model Selection operates interface；
Fig. 4 is that the correction of insulin pump LCDs foundation rate calculates interface；
Fig. 5 is insulin pump LCDs daily schedule correct operation interface；
Fig. 6 is the operation interface that insulin pump LCDs adjusts a certain period infusion amount.
Detailed description of the invention
Below this, technical scheme in embodiment of the present invention is clearly and completely described, it is clear that described reality
Executing example is only a part of embodiment of the present invention rather than whole embodiments.Based on the embodiment in the present invention, this area is general
The every other embodiment that logical technical staff is obtained under not making creative work premise, broadly falls into the model of present invention protection
Enclose.
The present embodiment provides the method for building up of a kind of insulin pump foundation infusion model, comprises the following steps:
For according to substantial amounts of clinical data, setting up the step of foundation rate infusion model；
For foundation rate infusion model being stored the step in insulin pump storage device；
For the signal inputted according to insulin pump input unit, by the step controlling device selection foundation rate infusion model；
Insulin-type, basis daily amount and the foundation rate infusion model of selection inputted by input unit for basis, by
Control device control insulin pump transmission propulsion unit and carry out the step of infusion of insulin.
Wherein, set up foundation rate infusion model to comprise the following steps:
(1) select the crowd by physiological property classification, carry out dynamic glucose test for this class crowd, and be this type
Experimental subjects set up the foundation rate change curve diagram data of its correspondence；
(2) comprehensive all of curve diagram data, the change of the amount of insulin that can sum up one day pancreatic secretion of Chinese is bent
Line datagram (see Fig. 1).This step is according to all of curve map, simulates the change curve datagram of an amount of insulin.
(3) being a time period with half an hour, datagram improvement becomes the time period accounts for the percentage of basis daily amount,
Obtain foundation rate infusion model (see Fig. 2).
The percentage that per time period accounts for basis daily amount is as shown in table 1.
Table 1
| Time period (hour) | 00-01 | 01-02 | 02-03 | 03-04 | 04-05 | 05-06 | 06-07 | 07-08 |
| Basic crack (U) | 2.11 | 2.82 | 3.42 | 4.5 | 7.11 | 8.27 | 6.54 | 5.00 |
| Time period (hour) | 08-09 | 09-10 | 10-11 | 11-12 | 12-13 | 13-14 | 14-15 | 15-16 |
| Basic crack (U) | 3.44 | 3.42 | 3.42 | 3.42 | 3.42 | 3.42 | 3.81 | 5.00 |
| Time period (hour) | 16-17 | 17-18 | 18-19 | 19-20 | 20-21 | 21-22 | 22-23 | 23-24 |
| Basic crack (U) | 5.53 | 5.53 | 4.47 | 3.97 | 3.33 | 3.33 | 2.64 | 2.07 |
Selecting the basal insulin rate infusion model (its operation interface is as shown in Figure 3) of above-mentioned foundation, the insulin of infusion is short
Effect insulin, daily amount is the basic crack (being shown in Table 2) that 24U (1U=0.01mL) comparison Fig. 2 can draw each time period.
Table 2
If patient compares few two time zones in In Wulumuqi with Beijing time, if with Semilente Insulin, medicine
Thing onset time than short-acting insulin fast about 1 little time, so arrange foundation rate than table 1 step back 3 little time, its operation interface such as
Shown in Fig. 4, it is shown in Table 3 through revised foundation rate.
Table 3
If the actual measurement blood sugar of patient is 6.3 mMs every liter as 0:00, target blood glucose is 6.0 mMs every liter, then
High blood glucose 0.3 mM every liter, it is assumed that the insulin sensitivity coefficient of patient is 1.5 mMs of every liter of per units, input fill
Put input blood glucose fluctuation value, perform correction and calculate, it can be deduced that patient should add
Big basis daily amount to 30U, revised foundation rate such as table 4.
Table 4
The process that execution correction calculates: patient's insulin input quantity=0.8+ (6.3-6.0)/1.5=1.0U during 0:00, comparison
Fig. 2 or table 1, it can be deduced that patient should strengthen basis daily amount to 30U.
Also can operation interface as shown in Figure 5, only correct several hours interior basic crack.
Wherein, if the infusion amount of certain time period need to be changed, it is also possible to according to the signal of insulin pump input unit input,
By the step controlling device adjustment foundation rate certain time period infusion amount of infusion model.Insulin pump operates interface as shown in Figure 6,
The infusion of insulin amount of certain period can be adjusted by operation insulin pump button.
Claims (1)
1. the method for building up of an insulin pump basal rate infusion model, it is characterised in that comprise the following steps: (1) selects at least
Two kinds, by the crowd of physiological property classification, carry out dynamic glucose test for each class crowd, and build for all types of experimental subjects
The foundation rate change curve diagram data of its correspondence vertical；(2) comprehensive all of curve diagram data, can sum up one day pancreatic secretion
The change curve datagram of amount of insulin, this step is that the change simulating an amount of insulin is bent according to all of curve map
Line datagram；(3) being a time period with half an hour, datagram improvement becomes the time period accounts for the percentage of basis daily amount,
Obtain foundation rate infusion model.
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| CN105311702B (en) * | 2014-09-03 | 2019-10-08 | 上海移宇科技股份有限公司 | Disposable duct free drug infusion system |
| CN105688308A (en) * | 2014-11-13 | 2016-06-22 | 上海泽生科技开发有限公司 | An injection pump control method and control unit and an injection pump |
| WO2017152346A1 (en) * | 2016-03-07 | 2017-09-14 | Medtrum Technologies Inc. | Tubeless fluid delivery system |
| CN111388796B (en) * | 2020-03-24 | 2022-05-03 | 首都医科大学宣武医院 | Syringe Pump Timing Devices and Syringe Pumps |
| CN113952542A (en) * | 2021-09-10 | 2022-01-21 | 深圳文西生物医疗科技有限公司 | Insulin pump basal rate control method, infusion device and monitoring system |
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| 不同时段胰岛素泵基础量设置治疗2型糖尿病的疗效;王晓薇;《中国药师》;20100630;第13卷(第6期);正文第2页 * |
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