CN103083522B - Traditional Chinese medicine composition for hair growing and hair nourishing, as well as preparation method and application thereof - Google Patents
Traditional Chinese medicine composition for hair growing and hair nourishing, as well as preparation method and application thereof Download PDFInfo
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- CN103083522B CN103083522B CN201210523830.3A CN201210523830A CN103083522B CN 103083522 B CN103083522 B CN 103083522B CN 201210523830 A CN201210523830 A CN 201210523830A CN 103083522 B CN103083522 B CN 103083522B
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Abstract
The invention belongs to the field of traditional Chinese medicines, relates to a traditional Chinese medicine composition for hair growing and hair nourishing, and an application of the traditional Chinese medicine composition in treatment of folliculitis decalvans, alopecia, alopecia areata or anaphalantiasis, and aims at overcoming the defects of the conventional chemical medicines for treating the diseases relative to alopecia, such as higher hepatotoxicity and high skin irritation. The traditional Chinese medicine composition for hair growing and hair nourishing comprises the following components: cinnamon leaf, longana mycorhiza, willow branch, cynomorium songaricum, radix asparagi, acanthopanax, folium ginkgo, commelina communis, lotus leaf, orange peel, folium eriobotryae and dateplum persimmon. The traditional Chinese medicine composition is high in recovery rate and less in skin irritation during being applied to treatment of the diseases relative to alopecia, and has good promotion effect on hair growing and the hair nourishing, and is remarkable in clinical promotional value.
Description
Technical field
The invention belongs to field of medicaments, relate to a kind of Chinese medicine composition and application thereof, be specifically related to a kind of Chinese medicine composition of generating hair and as the application of generating hair medicine.
Background technology
Pathologic alopecia refers to abnormal or excessive the coming off of hair, and its cardinal symptom is that hair is greasy, also or shrivelledly send out fluffy, lacks gloss, have faint yellow squama set difficult de-, or canescence squama is flown upward.Along with people's work and the quickening of rhythm of life, increasing the weight of and other reasons of mental work load, causes the phenomenon of alopecia more and more general.
The cause of disease that causes alopecia has a lot, and the traditional Chinese medical science is thought hair is the sign of blood condition, and alopecia is mainly because deficiency of the liver and kindey causes.Modern medicine thinks that alopecia and inherited genetic factors, hormonal readiness and trophic factor have very close contacting.Alopecia mainly comprises following a few class by its reason: 1. seborrheic alopecia: seborrheic alopecia is called as " cancer " in alopecia, its treatment is a global problem, and a major reason that causes this present situation is not yet to have at present the most directly and the most fruitful medicine.Current western medical treatment male seborrheic alopecia, because male pattern baldness is relevant with dihydrotestosterone concentration in body.Have research to point out that women's seborrheic alopecia and scalp testosterone levels increase relevant, and raise with dihydrotestosterone level, have nothing to do, this explanation women's seborrheic alopecia should be take the treatment of androgen antagonist medicine as main.2. pathologic alopecia: mainly due to virus, antibacterial, high heat, hair follicle is had to damage, suppressed hair follicle proper splitting, make hair follicle cause alopecia in shock state, as acute infectious disease, certain medicine of long-term taking etc.3. alopecia of chemical origin: harmful chemical causes alopecia to the infringement of scalp tissue, hair follicle cell.4. physical property alopecia: air pollutants are stopped up the alopecia that the reasons such as hair follicle, harmful radiation cause.5. trophism alopecia: digest and assimilate malfunction and cause malnutrition to cause alopecia.6. obesity-related alopecia: a large amount of satisfied fatty acid produces refuse after metabolism in vivo, stops up hair follicle and causes alopecia.7. hereditary alopecia: alopecia is also to have geneticly, and general male is dominant inheritance, women's heredity that is negative.
At present, numerous for preventing and treating the medicine of alopecia, hair growth promoting on market, but contain a large amount of chemical compositions, hormone composition and harmful chemical substance in the hair growth promoting medicament of most medical or cosmetics, even the heavy metal severe overweights such as plumbous hydrargyrum in some medicine, are having a strong impact on patient's use and hair recovery.Due to these Western medicine mostly there is potential hepatotoxicity and action target spot single, what is more important, the untoward reaction problem that educating on market sent out product is more serious, safety issue is more outstanding, irritative response, allergy, phototoxic reaction incidence rate are higher, thereby, determined curative effect, safely and fast, educating of prescription science send out a product and pursued by numerous doctors patient.
The history of Chinese medicine alopecia is of long standing and well established, and as an importance of modern generating hair Comprehensive Treatment, more and more receives publicity in recent years.Patent application CN101810554A discloses a kind of hair-growing composition of defending the doctrine being comprised of Radix Ginseng extract, Radix Salviae Miltiorrhizae extract, Radix Notoginseng extract, Cortex Dictamni extract, Rhizoma Chuanxiong extract and Fructus Zanthoxyli extract, and this Chinese medicine composition is promoting to have shown good therapeutic effect aspect hair growth.Patent CN101513503B has protected a kind of a kind of hair-growing and anti-hair loss Chinese medicine composition being comprised of Chinese medicines such as the ripe Radix Polygoni Multiflori, Radix Angelicae Sinensis, Radix Rehmanniae, Radix Rehmanniae Preparata, Semen Cuscutae.
Make a general survey of the research direction of world's new drug, be mainly single chemicals and preparations thereof of research and development the eighties in the past, starts to develop biotechnology and natural medicinal plants after the eighties, and drug research direction is tending towards multiformity.In conjunction with modern Chinese medicine theory of development, from improving the angle of curative effect of medication, reduction side effect, through Chinese medicine ingredients being screened to the preparation that extraction and/or compatibility make, its side effect is little, safe, has the advantage that chemical synthetic drug can not be compared.
Summary of the invention
Deficiency for current generating hair clinical treatment medicine, first object of the present invention is to provide a kind of Chinese medicine composition of generating hair, and this Chinese medicine composition has good therapeutic effect aspect hair growth folliculitis, alopecia, alopecia areata and milphae.Chinese medicine composition for generating hair of the present invention, it comprises following component: basyleaves, Arillus Longan shuttle, Ramulus Salicis Babylonicae, Herba Cynomorii, Radix Asparagi, Radix Et Caulis Acanthopanacis Senticosi, Folium Ginkgo, Herba Commelinae, Folium Nelumbinis, orange peel, Folium Eriobotryae and black worm Chinese date.Effect according to above-mentioned Chinese medicine composition for generating hair, Chinese medicine composition of the present invention, according to components by weight percent meter, preferably include following component: basyleaves 15-25 part, Arillus Longan shuttle 12-18 part, Ramulus Salicis Babylonicae 12-18 part, Herba Cynomorii 3-6 part, Radix Asparagi 8-12 part, Radix Et Caulis Acanthopanacis Senticosi 8-12 part, Folium Ginkgo 3-6 part, Herba Commelinae 10-20 part, Folium Nelumbinis 8-12 part, orange peel 8-12 part, Folium Eriobotryae 8-12 part, black worm Chinese date 5-15 part.
Still more preferably, Chinese medicine composition of the present invention, according to components by weight percent meter, comprise following component: 20 parts of basyleaves, 15 parts, Arillus Longan shuttle, 15 parts of Ramulus Salicis Babylonicae, 5 parts of Herba Cynomoriis, 10 parts of Radix Asparagi, 10 parts of Radix Et Caulis Acanthopanacis Senticosis, 5 parts of Folium Ginkgos, 15 parts of Herba Commelinaes, 10 parts, Folium Nelumbinis, 10 parts of orange peels, 10 parts of Folium Eriobotryaes, 10 parts of black worm Chinese dates.
Cortex Cinnamomi, Lauraceae common Chinese medicine, has another name called Chinese cinnamon, and main product is in provinces such as Yunnan Province of China, Guangxi, Guangdong, Fujian, mainly with its bark or branch skin, be used as medicine clinically, there is the fire of benefit supporing yang, let the fire back to its origin, dispersing cold for relieving pain, the effect of promoting blood circulation to restore menstrual flow, has warming the spleen and stomach concurrently, removing accumulated cold, the effect of promoting blood circulation.Cure mainly clinically the diseases such as sexual impotence, cold womb, trusted subordinate's cold type of pain, deficiency and coldness vomiting and diarrhoea, amenorrhea, dysmenorrhea, warming the meridian and promoting blood circulation.In Chinese medicine composition of the present invention, with basyleaves, be used as medicine, the pungent taste temperature of its property, has warming spleen and stomach for dispelling cold, relieving the exterior syndrome by diaphoresis effect.Clinically cure mainly that affection of exogenous wind-cold, headache aversion to cold, cough, cold syndrome of the stomach are uncomfortable in chest, the disease such as gastralgia vomiting, stomachache are had loose bowels, chilblain.
Arillus Longan shuttle is the bacterial parasite on sapindaceous plant longan, is mainly distributed in middle part and the east of China, especially maximum with Fujian, Guangdong, Guangxi.Its property is flat lightly seasoned, has the effect of activating QI, cough-relieving, antiinflammatory, is mainly used in clinically treating the diseases such as phlegm-fire cough, stomachache, hernia, prior art discovery, and it also has treatment puerperal thirst, the rotten the first-born poison wind illness for the treatment of children's and the texts of enriching blood.
Willow is common deciduous tree, and Ramulus Salicis Babylonicae is the synthetism panacea that the traditional Chinese medical science is traditional, has the effect of dispelling wind and removing dampness.After being decocted in water for oral dose, can treat coronary heart disease, chronic bronchitis, urinary tract infection, burn and scald etc., decocting fumigation and wash method, has obvious curative effects to rheumatic, rheumatoid arthritis.
Herba Cynomorii is the parasitic draft of perennial meat, is the Herba indigoferae Pseudotinctoriae the most often using in the medical material of the kidney invigorating, and it can suppressing the hyperactive liver the kidney invigorating, beneficial intensive culture blood, loosening bowel to relieve constipation, and the infertility that treatment insufficiency of vital energy and blood causes also can strengthening the tendons and bones, supplement calcium.Function of human body is had to very large benefit; Strengthen immunologic function; Remove free radical; Antiplatelet aggregation; There is the effect of saccharide 17-hydroxy-11-dehydrocorticosterone sample; Vitimin supplement and mineral.Up-to-date scientific experiments proof Herba Cynomorii also has the effect of anti-cancer, antiviral, slow down aging.Be applicable to hypoimmunity, easy infection disease patient; Young and middle-aged hardworking cause and healthy overdraw person; The multiple patients with chronic diseases such as frequent micturition constipation, insomnia alopecia, asthma, the weak premature ejaculation of flaccidity.
Radix Asparagi is the tuber that Liliaceae asparagus plant has the spindle meat that clusters, and has replenishing YIN and removing heat, moisturizes the effect of promoting the production of body fluid.Cure mainly the diseases such as pulmonary tuberculosis, bronchitis, diphtheria, pertussis, dryness of the mouth and throat, calentura are thirsty, diabetes, constipation due to dry stool; Sore swollen toxin is controlled in external, venom.Modern medicine confirms that Radix Asparagi is containing asparagine, β-sitosterol, steroid saponin, the compositions such as phlegmatic temperament, furfural derivatives, and it has significant antibacterial action, antitumor action and Antitussive and Expectorant Effect.
Radix Et Caulis Acanthopanacis Senticosi is regarded as having the good medicine that adds essence benefit marrow and anti-aging effects from ancient times.Commodity are called Radix Acanthopanacis Senticosi, and former main product is in mountain area, Heilongjiang Province, and local popular name is practised and claimed " tiger is hasty and careless ", its slightly warm in nature, acrid in the mouth, micro-hardship.Return spleen, kidney, heart channel, clinical be used for the treatment of anemofrigid-damp arthralgia, lumbocrural pain, muscles and bones flaccidity soft, be slow in action, the disease such as body weakness with emaciation is weak, traumatic injury, uncontrolled urination are itched.Modern medicine studies have shown that effect feature and the Radix Ginseng of Radix Et Caulis Acanthopanacis Senticosi is basic identical, has the body of adjusting disorderly, makes it to be tending towards normal function; There is good antifatigue effect, and can significantly improve hypoxia-bearing capability; It has the functions such as invigorating middle warmer, benefit essence, strong will, wind-damp dispelling, strengthening bone and muscle, blood circulation and promoting silt, stomach invigorating diuresis.Take for a long time " make light of one's life by commiting suicide and endure hardships ".Eleutheroside in Radix Et Caulis Acanthopanacis Senticosi can stimulate mind & body vigor.Numerous scientific publications about Radix Et Caulis Acanthopanacis Senticosi have proved its antifatigue effect, strengthen endurance and ability, increase alertness and learning capacity.Numerous usages have all obtained confirmation in human experimentation.Radix Et Caulis Acanthopanacis Senticosi is rehabilitation after being ill, bears too much pressure or anxiety, works excessive, and chronic disease causes weakly crowd and those need to reach very welcome self-medication medicine in the people on physiology and psychological performance peak.
Ginkgo has another name called the rarity of maidenhair tree ，Shi China, rare valuable, is described as " hollywood lignumvitae ", " living fossil " of the earth.In Folium Ginkgo, contain the multiple components useful with health such as natural activity flavone and amarolide, there is dissolving cholesterol, the effect of blood vessel dilating, has positive effect to improving disordered brain function, arteriosclerosis, hypertension, dizzy, tinnitus, headache, senile dementia, hypomnesis etc.Its diseases prevention, cure the disease, the value of body-building is early on the books in the < of Ming Dynasty's Li Shizhen (1518-1593 A.D.) < Compendium of Materia Medica > >.Through national health department, detect proof: drink Folium Ginkgo tea and can obviously reduce serum cholesterol, triglyceride and low-density blood lipoprotein, reduce the effect of depot lipid in body.For the complementary controls of diseases of cardiovascular and cerebrovascular systems patient such as adjusting, hypertension and coronary heart disease of hyperlipidemia and obese type crowd's fat-reducing etc., having good effect, is the desirable beverage of prophylactic treatment senile dementia.Be recognized in the worldly control, the optimal pharmaceutical compositions of anti-cardiovascular and cerebrovascular disease.
Herba Commelinae is Commelianaceae herbaceous plant, and China's most area all has distribution.It is cold in nature, sweet in the mouth, micro-hardship.There is heat clearing away, removing toxic substances, the effect of diuresis.Its water decoction all has inhibitory action to staphylococcus aureus, sarcine, has trivial solution heat effect.Clinical in epidemic febrile disease edema caused by disorder of QI excess-heat, heating xerostomia, or exterior heat syndrome heating; Laryngopharynx swelling and pain, carbuncle sore tumefacting virus, or venom; Dysentery; Pyretic stranguria, oliguria with reddish urine, or edema, dysuria and have hot person.
Folium Nelumbinis is the leaf of nymphaeaceae plant lotus, and national most area is all produced.Folium Nelumbinis bitter in the mouth is pungent micro-puckery, cool in nature, and GUIXIN, liver, spleen channel, delicate fragrance rise loose; There is summer heat relieving and dampness eliminating, spleen invigorating yang invigorating, the effect of dissipating blood stasis hemostasis.Cure mainly summer-heat excessive thirst, have a headache dizzy, edema, lack of appetite abdominal distention, dysentery, leucorrhea, proctoptosis, spits blood, epistaxis, spitting of blood, has blood in stool, metrorrhagia, post partum longtime lochia, traumatic blood stasis.Modern medicine confirms that Folium Nelumbinis all has certain therapeutic effect to diarrhoea, edema, hyperlipidemia and dermatosis.
Orange peel is because the time of its placement is more of a specified duration, and its drug effect is stronger, therefore named Pericarpium Citri Reticulatae.Chinese medicine thinks that Pericarpium Citri Reticulatae acrid in the mouth is bitter, warm in nature, has the effect of warming stomach for dispelling cold, regulating qi-flowing for strengthening spleen, and the people who is applicable to the symptoms such as stomach distension, dyspepsia, inappetence, cough ant phlegm is edible.Modern study shows, contains the compositions such as a large amount of volatile oil, hesperidin in Pericarpium Citri Reticulatae, and its contained volatile oil has gentle stimulation to gastrointestinal tract, and pneumatosis in intestinal is got rid of in secretion that can facilitating digestion liquid, increases appetite.
Folium Eriobotryae is the leaf of rosaceous plant Folium Eriobotryae, has another name called Ba Ye, Lu Juye.Its cold nature, bitter in the mouth is pungent, has clearing away lung-heat to relieve cough, regulating the stomach and sending down the abnormal ascending QI, the effect of quenching the thirst.Function cures mainly clearing away lung-heat to relieve cough, stopping nausea and vomiting by lowering the adverse flow of QI.Cough due to lung-heat, QI rising in reverse order dyspnea with rapid respiration, gastropyretic vomiting, the diseases such as hiccup.Modern medicine confirms that it has stronger Antitussive and Expectorant Effect, antibacterial action and certain antiinflammatory action.
Black worm Chinese date, formal name used at school Fructus Dispyroris Loti, claims again wild Fructus Kaki, belongs to Ebenaceae Diospyros, is distributed widely in the northern area of China.One of traditional the kidney invigorating food " reactionary gang ".Fructus Jujubae has abundant nutritive value, as carbohydrate, dietary fiber, fat, pectin and protein etc., also contain abundant vitamin and mineral simultaneously, the more important thing is and in Fructus Jujubae, contains the bioactive substances such as tannin and flavochrome.Fructus Jujubae contains the nutritional labelings such as protein, saccharide, organic acid, vitamin and phosphorus, calcium, ferrum.Fructus Jujubae sweet in the mouth warm in nature, has the kidney invigorating and nourishing the stomach effect, has the title in " nutrition warehouse "
In Chinese medicine composition of the present invention, Cortex Cinnamomi, Radix Et Caulis Acanthopanacis Senticosi and Herba Cynomorii can play the effect fiery supporing yang, warming spleen and stomach for dispelling cold of mending.Radix Asparagi, Cortex Cinnamomi and Ramulus Salicis Babylonicae can blood circulation promoting and blood stasis dispelling, removing mass dredging collateral, replenishing YIN and removing heat; Arillus Longan shuttle, Folium Eriobotryae, Folium Nelumbinis, orange peel and Herba Commelinae can antiphlogistic antibacterials, summer heat relieving and dampness eliminating, eliminating stagnation induce sweat.Black worm Chinese date, Radix Et Caulis Acanthopanacis Senticosi and Folium Ginkgo can improve head blood circulation, nutrition hair.All medicines share, and play altogether the effect of antiphlogistic antibacterial, removing mass dredging collateral, activating blood circulation to dissipate blood stasis, dispelling phlegm and eliminating dampness.
The invention provides a kind of method of preparing Chinese medicine composition of the present invention, it comprises the steps: 1) take each component of above-mentioned weight portion, respectively basyleaves, Folium Ginkgo, Folium Eriobotryae, Folium Nelumbinis are soaked in mature vinegar; Arillus Longan shuttle, Ramulus Salicis Babylonicae, Herba Cynomorii, Radix Asparagi, Radix Et Caulis Acanthopanacis Senticosi are soaked in rice water; Herba Commelinae, orange peel, black worm Chinese date are soaked in spring water; Soak time is no less than 24 hours; 2) use respectively vigorous fire boiled three class medical materials after soaking, filter after boiling 1 hour with slow fire; Filtrate that three class medical materials are boiled merges, and adds after 20 portions of tea mushroom cakes boiled with vigorous fire.3) after filtration, filtrate is cooling rear standby.The thin medicated powder of the above-mentioned Chinese medicine composition of the present invention can further be prepared into conventional clinically pharmaceutical preparation, is preferably mixture.
The invention provides the another kind of method of prepare Chinese medicine composition of the present invention, each component that it comprises the steps: to take the above-mentioned weight portion of the present invention, is ground into mistake 200 mesh sieves after powder, obtains the thin medicated powder of Chinese medicine composition.The thin medicated powder of the above-mentioned Chinese medicine composition of the present invention can further be prepared into conventional clinically pharmaceutical preparation, is preferably liniment, unguentum or gel.The pharmaceutic adjuvant of described pharmaceutical preparation is selected and preparation technology is that appearance is facile to those skilled in the art.
The present invention also discloses a kind of purposes of above-mentioned Chinese medicine composition, and above-mentioned Chinese medicine composition is being prepared hair growth promoting or educated the purposes of sending out in medicine.Wherein said Chinese medicine composition, when for generating hair, can adopt suitable route of administration administration, and the preferred external of the present invention is smeared administration or applied and press.Chinese medicine composition of the present invention for educating the Therapeutic Method occurring is: first use steamed 5-10 minute scalp, then medicine is smeared to scalp place, then beat and massaging scalp 10-15 minute.The embodiment of the present invention 10 proof Chinese medicine composition of the present invention is high to disease cured rates such as folliculitis decalvans, alopecia, alopecia areata, milphaes, patient's compliance is high, wherein adopts the therapeutic effect of preparation method described in the embodiment of the present invention 3 and formula best.
The embodiment of the present invention 10 is tested by investigating the treatment of Chinese medicine composition xylol induced mice model of the present invention, find that Chinese medicine composition external provided by the invention smears the left and right ear method of double differences that administration can significantly reduce ear swelling mice, its antiphlogistic effects and hydrocortisone are quite or be better than its antiphlogistic effects.This may can improve skin surface microcirculation with Chinese medicine composition of the present invention, enhances metabolism relevant.The embodiment of the present invention 11 is by investigating the bacteriostatic experiment of Chinese medicine composition of the present invention to external various pathogens, find that Chinese medicine composition of the present invention all has good inhibitory action to various pathogens, its minimal inhibitory concentration is low, therefore can reduce scalp surface courses of infection disease and then stop up pore.The embodiment of the present invention 12 proved invention Chinese medicine compositions can significantly promote animal wool body to increase, and its gross weight, hair is thick and staple length and matched group all have the difference of significance.The embodiment of the present invention 13 has been studied the skin irritation of Chinese medicine composition, finds that Chinese medicine composition skin irritation of the present invention is little, with matched group no difference of science of statistics, is significantly better than existing commercially available alopeciaing therapeutic medicine.
In a word, the present invention compared with prior art, has the activity of fine generating hair, and can the present invention be pure Chinese medicinal preparation, and skin irritation is little, to human body avirulence.The present invention is during as the drug use of alopecia treating correlative diseases, and drug effect is comprehensive, when, eliminating stagnation antibacterial in antiinflammatory induced sweat, can also obtain the effect of activating blood circulation to dissipate blood stasis, dispelling phlegm and eliminating dampness, can make rapidly alopecia relevant disease conditions of patients take a turn for the better; Chinese medicine composition of the present invention can also improve scalp surface microcirculation, nourishes hair and Chinese medicine composition of the present invention preparation simply, and substantially nontoxic, raw material is easy to get, and is suitable for popular use, has good application prospect.
The specific embodiment
By the specific embodiment, further describe the present invention below, but the present invention is not limited only to following examples.Within the scope of the invention or within not departing from content of the present invention, spirit and scope, Chinese medicine composition of the present invention is suitably improved, replaces the component that effect is identical, within will become apparent to those skilled in the art that they are all deemed to be included in scope of the present invention.
first, the preparation of Chinese medicine composition of the present invention
embodiment 1 Chinese medicine composition mixture of the present invention
Prescription: 15 parts of basyleaves, 12 parts, Arillus Longan shuttle, 12 parts of Ramulus Salicis Babylonicae, 3 parts of Herba Cynomoriis, 8 parts of Radix Asparagi, 8 parts of Radix Et Caulis Acanthopanacis Senticosis, 3 parts of Folium Ginkgos, 10 parts of Herba Commelinaes, 8 parts, Folium Nelumbinis, 8 parts of orange peels, 8 parts of Folium Eriobotryaes, 5 parts of black worm Chinese dates.
Preparation method: take each component of above-mentioned weight portion, respectively basyleaves, Folium Ginkgo, Folium Eriobotryae, Folium Nelumbinis are soaked in mature vinegar; Arillus Longan shuttle, Ramulus Salicis Babylonicae, Herba Cynomorii, Radix Asparagi, Radix Et Caulis Acanthopanacis Senticosi are soaked in rice water; Herba Commelinae, orange peel, black worm Chinese date are soaked in spring water; Soak time is 24 hours; 2) use respectively vigorous fire boiled three class medical materials after soaking, filter after boiling 1 hour with slow fire; Filtrate that three class medical materials are boiled merges, and adds after 20 portions of tea mushroom cakes boiled with vigorous fire.3) after filtrate is cooling after filtering, obtain mixture.
embodiment 2 Chinese medicine composition mixture of the present invention
Prescription: 25 parts of basyleaves, 18 parts, Arillus Longan shuttle, 18 parts of Ramulus Salicis Babylonicae, 6 parts of Herba Cynomoriis, 12 parts of Radix Asparagi, 12 parts of Radix Et Caulis Acanthopanacis Senticosis, 6 parts of Folium Ginkgos, 20 parts of Herba Commelinaes, 12 parts, Folium Nelumbinis, 12 parts of orange peels, 12 parts of Folium Eriobotryaes, 15 parts of black worm Chinese dates.
Preparation method: take each component of above-mentioned weight portion, respectively basyleaves, Folium Ginkgo, Folium Eriobotryae, Folium Nelumbinis are soaked in mature vinegar; Arillus Longan shuttle, Ramulus Salicis Babylonicae, Herba Cynomorii, Radix Asparagi, Radix Et Caulis Acanthopanacis Senticosi are soaked in rice water; Herba Commelinae, orange peel, black worm Chinese date are soaked in spring water; Soak time is 30 hours; 2) use respectively vigorous fire boiled three class medical materials after soaking, filter after boiling 1 hour with slow fire; Filtrate that three class medical materials are boiled merges, and adds after 20 portions of tea mushroom cakes boiled with vigorous fire.3) after filtrate is cooling after filtering, obtain mixture.
embodiment 3 Chinese medicine composition mixture of the present invention
Prescription: 20 parts of basyleaves, 15 parts, Arillus Longan shuttle, 15 parts of Ramulus Salicis Babylonicae, 5 parts of Herba Cynomoriis, 10 parts of Radix Asparagi, 10 parts of Radix Et Caulis Acanthopanacis Senticosis, 5 parts of Folium Ginkgos, 15 parts of Herba Commelinaes, 10 parts, Folium Nelumbinis, 10 parts of orange peels, 10 parts of Folium Eriobotryaes, 10 parts of black worm Chinese dates.
Preparation method: take each component of above-mentioned weight portion, respectively basyleaves, Folium Ginkgo, Folium Eriobotryae, Folium Nelumbinis are soaked in mature vinegar; Arillus Longan shuttle, Ramulus Salicis Babylonicae, Herba Cynomorii, Radix Asparagi, Radix Et Caulis Acanthopanacis Senticosi are soaked in rice water; Herba Commelinae, orange peel, black worm Chinese date are soaked in spring water; Soak time is 24 hours; 2) use respectively vigorous fire boiled three class medical materials after soaking, filter after boiling 1 hour with slow fire; Filtrate that three class medical materials are boiled merges, and adds after 20 portions of tea mushroom cakes boiled with vigorous fire.3) after filtrate is cooling after filtering, obtain mixture.
embodiment 4 Chinese medicine composition mixture of the present invention
Prescription: 18 parts of basyleaves, 18 parts, Arillus Longan shuttle, 16 parts of Ramulus Salicis Babylonicae, 5 parts of Herba Cynomoriis, 8 parts of Radix Asparagi, 12 parts of Radix Et Caulis Acanthopanacis Senticosis, 5 parts of Folium Ginkgos, 15 parts of Herba Commelinaes, 9 parts, Folium Nelumbinis, 10 parts of orange peels, 12 parts of Folium Eriobotryaes, 8 parts of black worm Chinese dates.
Preparation method: take each component of above-mentioned weight portion, respectively basyleaves, Folium Ginkgo, Folium Eriobotryae, Folium Nelumbinis are soaked in mature vinegar; Arillus Longan shuttle, Ramulus Salicis Babylonicae, Herba Cynomorii, Radix Asparagi, Radix Et Caulis Acanthopanacis Senticosi are soaked in rice water; Herba Commelinae, orange peel, black worm Chinese date are soaked in spring water; Soak time is 24 hours; 2) use respectively vigorous fire boiled three class medical materials after soaking, filter after boiling 1 hour with slow fire; Filtrate that three class medical materials are boiled merges, and adds after 20 portions of tea mushroom cakes boiled with vigorous fire.3) after filtrate is cooling after filtering, obtain mixture.
embodiment 5 Chinese medicine composition mixture of the present invention
prescription:15 parts of basyleaves, 18 parts, Arillus Longan shuttle, 18 parts of Ramulus Salicis Babylonicae, 5 parts of Herba Cynomoriis, 10 parts of Radix Asparagi, 9 parts of Radix Et Caulis Acanthopanacis Senticosis, 6 parts of Folium Ginkgos, 20 parts of Herba Commelinaes, 10 parts, Folium Nelumbinis, 11 parts of orange peels, 10 parts of Folium Eriobotryaes, 12 parts of black worm Chinese dates.
Preparation method: take each component of above-mentioned weight portion, respectively basyleaves, Folium Ginkgo, Folium Eriobotryae, Folium Nelumbinis are soaked in mature vinegar; Arillus Longan shuttle, Ramulus Salicis Babylonicae, Herba Cynomorii, Radix Asparagi, Radix Et Caulis Acanthopanacis Senticosi are soaked in rice water; Herba Commelinae, orange peel, black worm Chinese date are soaked in spring water; Soak time is 24 hours; 2) use respectively vigorous fire boiled three class medical materials after soaking, filter after boiling 1 hour with slow fire; Filtrate that three class medical materials are boiled merges, and adds after 20 portions of tea mushroom cakes boiled with vigorous fire.3) after filtrate is cooling after filtering, obtain mixture.
embodiment 6 Chinese medicine composition composition liniment of the present invention
Chinese medicine composition prescription: 15 parts of basyleaves, 18 parts, Arillus Longan shuttle, 18 parts of Ramulus Salicis Babylonicae, 5 parts of Herba Cynomoriis, 10 parts of Radix Asparagi, 9 parts of Radix Et Caulis Acanthopanacis Senticosis, 6 parts of Folium Ginkgos, 20 parts of Herba Commelinaes, 10 parts, Folium Nelumbinis, 11 parts of orange peels, 10 parts of Folium Eriobotryaes, 12 parts of black worm Chinese dates.
Compositions fine powder preparation: take each Chinese medicinal components of above-mentioned weight portion, cross 200 mesh sieves after being ground into powder, obtain the thin medicated powder of Chinese medicine composition.
Preparation prescription:
Preparation technology: take prescription and measure zinc sulfate fine powder and urea granules, after mixing, in mortar, be milled to fine powder, add again glycerol to grind evenly fast, add a small amount of purified water repeatedly, all transfer in suitable vessel to mixture in mortar, add water appropriate, the thin medicated powder of the present embodiment Chinese medicine composition that adds recipe quantity, mixes, and adds bromo geramine, stir, finally add water to 1000ml.With 1%NaOH solution, adjust PH to 6.5 again, stir, standby.
embodiment 7 Chinese medicine composition composition liniment of the present invention
Chinese medicine composition prescription: 20 parts of basyleaves, 15 parts, Arillus Longan shuttle, 15 parts of Ramulus Salicis Babylonicae, 5 parts of Herba Cynomoriis, 10 parts of Radix Asparagi, 10 parts of Radix Et Caulis Acanthopanacis Senticosis, 5 parts of Folium Ginkgos, 15 parts of Herba Commelinaes, 10 parts, Folium Nelumbinis, 10 parts of orange peels, 10 parts of Folium Eriobotryaes, 10 parts of black worm Chinese dates.
Compositions fine powder preparation: take each Chinese medicinal components of above-mentioned weight portion, cross 200 mesh sieves after being ground into powder, obtain the thin medicated powder of Chinese medicine composition.
Preparation prescription:
2. preparation technology
The glycerol and the ethanol that first measure recipe quantity are dissolved in after a small amount of water, are diluted with water in right amount, add boric acid stirring and dissolving, then add the thin medicated powder of recipe quantity the present embodiment Chinese medicine composition, are stirred to dissolve evenly, finally add bromo geramine, continue to add water to 1000ml.With 1%NaOH solution, adjust PH to 6.5 left and right again, stir, standby.
embodiment 8 Chinese medicine composition unguentum of the present invention
Chinese medicine composition prescription: 18 parts of basyleaves, 18 parts, Arillus Longan shuttle, 16 parts of Ramulus Salicis Babylonicae, 5 parts of Herba Cynomoriis, 8 parts of Radix Asparagi, 12 parts of Radix Et Caulis Acanthopanacis Senticosis, 5 parts of Folium Ginkgos, 15 parts of Herba Commelinaes, 9 parts, Folium Nelumbinis, 10 parts of orange peels, 12 parts of Folium Eriobotryaes, 8 parts of black worm Chinese dates.
Compositions fine powder preparation: take each Chinese medicinal components of above-mentioned weight portion, cross 200 mesh sieves after being ground into powder, obtain the thin medicated powder of Chinese medicine composition.
Preparation prescription:
Preparation technology:
Get white vaseline, octadecanol, glyceryl monostearate, liquid Paraffin, methyl hydroxybenzoate mix homogeneously, in water-bath, heating makes fusing, and keeping temperature is 80 ℃ of left and right.
Separately get sodium lauryl sulphate and be dissolved in prescription water gaging, add glycerol, the thin medicated powder of the present embodiment Chinese medicine composition, boric acid, zinc sulfate to put and in water-bath, be heated to 80 ℃ of left and right.
Oil phase is slowly added in water, with adding with stirring, when temperature is down to 60 ℃, azone is slowly joined in emulsifiable paste matrix, stir cooling, and get final product.
embodiment 9 Chinese medicine composition gelata of the present invention
Composition prescription: 25 parts of basyleaves, 18 parts, Arillus Longan shuttle, 18 parts of Ramulus Salicis Babylonicae, 6 parts of Herba Cynomoriis, 12 parts of Radix Asparagi, 12 parts of Radix Et Caulis Acanthopanacis Senticosis, 6 parts of Folium Ginkgos, 20 parts of Herba Commelinaes, 12 parts, Folium Nelumbinis, 12 parts of orange peels, 12 parts of Folium Eriobotryaes, 15 parts of black worm Chinese dates.
Compositions fine powder preparation: take each Chinese medicinal components of above-mentioned weight portion, cross 200 mesh sieves after being ground into powder, obtain the thin medicated powder of Chinese medicine composition.
Preparation prescription:
The Carbomer-940 of getting recipe quantity adds in appropriate distilled water, makes its slow swelling, obtains carbomer gel shape thing; Get again HP-β-CD and add proper amount of boiling water it is dissolved, obtain HP-β-CD aqueous solution; Separately get the thin medicated powder of the present embodiment Chinese medicine composition, zinc sulfate, aspirin stirs in PEG-400.
After three-phase is merged, stir, add methyl hydroxybenzoate, ethyl hydroxybenzoate, azone, stir, add water to recipe quantity, stir, packing, obtains.
second portion, the pharmacodynamics of Chinese medicine composition of the present invention is investigated
the antiinflammatory action of embodiment 10 Chinese medicine composition xylol of the present invention induced mice inflammatory model
Hydrocortisone is that synthetic is also naturally occurring glucocorticoid, and hydrocortisone enters after cell, activates cytoplasmic receptor, after allosteric, enter nucleus, be combined with DNA response element, cause inhibition or the induction of genetic transcription, the expression of inflammation associated protein is changed.Hydrocortisone has stronger anti-inflammatory activity, is usually used in clinically the treatment of arthritis, conjunctivitis.
, experimental technique:
40 KM mices, male and female half and half, body weight 25-30 gram, by body weight, be divided at random four groups, i.e. dosage group in model control group, combination group high dose group, compositions, compositions low dose group, positive controls, every group 10, each administration group mice gives respectively following medicine:
Model control group: smear the normal saline that gives same volume;
Positive controls: gavage gives the hydrocortisone drug solution of 5mg/kg;
Compositions high dose group: smear and give 50mg/kg embodiment 1 Chinese medicine composition, Chinese medicine composition is by crude drug amount;
Dosage group in compositions: smear and give 20 mg/kg embodiment 1 Chinese medicine compositions, Chinese medicine composition is by crude drug amount;
Compositions low dose group: smear and give 5 mg/kg embodiment 1 Chinese medicine compositions, Chinese medicine composition is by crude drug amount;
Each administration group is administered once every day, successive administration 7d.After last administration, get dimethylbenzene 20 μ l, be applied to each mouse right ear.After 30 minutes, get and be respectively subject to reagent 0.03 ml to be evenly applied to respectively mouse right ear, auris dextra is put to death after 3.5 hours to dimethylbenzene, measures and respectively organizes the mice left and right ear method of double differences.Ear method of double differences assay method: place cuts two ears along auricle baseline, lays auricle with 8mm card punch at the same position of left and right ear, weighs, and the ear method of double differences=auris dextra sheet weight-left auricle weight.The ear method of double differences can be used as evaluates antiinflammatory index.
, experimental result:measure each experimental mice ear method of double differences and evaluate the antiphlogistic effects of each medication group medicine.Measurement result is in Table 2.
Each experimental mice ear method of double differences comparison of table 1
With model control group comparison,
* p< 0.05; With model control group comparison,
* p< 0.01;
With positive controls comparison,
# p< 0.05; With positive controls comparison,
## p< 0.01.
Result demonstration gives positive drug and Chinese medicine composition of the present invention all can be obtained significant antiphlogistic effects, wherein the antiphlogistic effects of Chinese medicine composition high dose group of the present invention and positive controls have utmost point significant difference, Chinese medicine composition low dose group and positive controls have significant difference, and this shows that the high dose group of Chinese medicine composition of the present invention and the antiphlogistic effects of low dose group will significantly be better than positive controls.
the In Vitro Bacteriostasis experiment of embodiment 11 Chinese medicine compositions of the present invention
The strain that this experiment is used and culture medium are respectively α-hemolytic streptococcus (32209), beta hemolytic streptococcus (32210), colon bacillus (44102), proteus vulgaris (49101), Salmonella paratyphi A (50001), shigella dysenteriae (51252), staphylococcus aureus [26111 (5)], hemophilus influenza (58529-4), nutrient agar (in tired pharmaceutical biological product calibrating institute); Opacity tube (Chinese bacterial turbidity standard, the biological combinations calibrating of Chinese medicine institute).
In Vitro Bacteriostasis experiment: 1. prepare pastille agar plate.Tested material is pressed to the culture medium of doubling dilution preparation different pharmaceutical concentration, heating, modulation is required pH value separately, and 121 ℃ of sterilizing 30 min, are chilled to 45 ℃.Pour into into aseptic flat board (plate d=
65 mm, 10 ml/ plates), finally make the extension rate containing tested material stock solution (2g/ml) in culture medium be respectively l:2,1:4 ... 1:1024.Do blank culture medium separately simultaneously.2. inoculation.Get the bacterium in young age that reaches the third generation, with 0.9% sodium chloride solution, by standard opacity tube corrected concentrations, be respectively the bacterium liquid to be checked of 108 cfu/ml, be inoculated in respectively the agar surface of pastille separately of different doubling dilutions, inoculate parallel point 3 points simultaneously, make at every containing 2 one bacterium liquid.The liquid-drop diameter of each vaccination is 5-8 mm.After vaccination is dry, upset is dull and stereotyped cultivates 20 h observed results (simultaneously doing blank) in 36 ℃ of constant incubators.3. criterion.Take and do not occur that the minimum dilution tested material concentration on the agar plate of bacterium colony is its minimum inhibitory concentration (MIC).
In this experiment, Chinese medicine composition is as shown in table 2 to the minimal inhibitory concentration of each pathogenic strain:
The minimal inhibitory concentration of table 2 Chinese medicine composition of the present invention to pathogenic strain
Result demonstration, Chinese medicine composition of the present invention all has good fungistatic effect to most pathogenic bacterium, and this is for hair growth relevant disease, and tool is of great significance.
The facilitation of embodiment 12 Chinese medicine composition of the present invention to animal wool bulk-growth
In this experiment, laboratory animal is selected Cavia porcellus, and body weight 100g-120g, purchased from Beijing Vital River Experimental Animals Technology Co., Ltd., 10 every group, cuts off back same area 3*3cm
2chaeta, with safety razor, scrape neat Rhizoma Imperatae, note avoiding injured skin.Smear respectively and give following medicine in 24 hours Hou unhairing districts, and coating 0.5mL/ only.
Matched group: smear the ethanol water that gives 80%;
Experimental group 1: smear and give the embodiment of the present invention 1 prepared Chinese medicine composition;
Experimental group 2: smear and give the embodiment of the present invention 2 prepared Chinese medicine composition;
Experimental group 3: smear and give the embodiment of the present invention 3 prepared Chinese medicine composition;
Experimental group 4: smear and give the embodiment of the present invention 4 prepared Chinese medicine composition;
Experimental group 5: smear and give the embodiment of the present invention 1 prepared Chinese medicine composition;
Each administration group is administered once every day, smears continuously administration and after 14 days, usings chaeta length, thickness and weight as index, relatively each administration group Cavia porcellus chaeta upgrowth situation (the results are shown in Table 3).In the middle of every Cavia porcellus administration district, 10 of chaetas are got at same area place at random, and film-making is also measured the length of chaeta, measures Rhizoma Imperatae portion with micrometer under optical microscope, and the cross section diameter of middle part and mao tip is got its meansigma methods thick as hair.
The impact of table 3 Chinese medicine composition of the present invention on Cavia porcellus hair growth
*compare with matched group, P < 0.01,
#compare P < 0.05 with 3 groups of experimental examples
In sum, to animal chaeta, growth has obvious facilitation to generating hair compositions of the present invention, its active component containing is the necessary material of hair follicle cell growth metabolism, external can directly infiltrate into hair follicle deep layer, makes hair follicle obtain sufficient nourishing, can suppress the too much secretion of sebaceous gland simultaneously, improve the oils and fats thromboembolism in follicular orifice, promote scalp blood circulation, increase blood flow, thereby make hair be able to Fast Growth.Experimental results show that, after successive administration 14 days, comparing each experimental group with model group can make hair increase more than 1/3rd, hair slightly increases more than 40%, chaeta weight increases more than 60, this shows adopt Chinese medicine composition hair staple length of the present invention, hair is thick and gross weight all has significant difference (P < 0.01) with model group, wherein experimental example 3 is compared with other experimental group and is had significant difference (P < 0.05) in the improvement degree of These parameters.
the repeatedly irritation test of embodiment 13 Chinese medicine compositions of the present invention
Laboratory animal selects regular grade white New Zealand to plant 4 of rabbit, before test, 24h shaves off back part of animal spinal column diamond wool, shave a mao scope left and right Ge Yue 3cm * 3cm, the Chinese medicine composition mixture of the present invention during test, tested material 0.5ml(being prepared by the embodiment of the present invention 3) be evenly applied on the 2.5cm * 2.5cm skin of left side, right side compares with distilled water.Smear every day once, continuously 14d.From second day, smear front unhairing every day, with warm water, clean, after 1h, observe dermoreaction and carry out skin irritation reaction scoring, after off-test, calculate respectively 14 days total marks, 14 days every animal integral mean values, every day, every animal integral mean value, and carried out skin irritation strength grading.Repeatedly irritation test result is as shown in table 4 for Chinese medicine composition of the present invention.
Table 4 Chinese medicine composition of the present invention is irritation test result repeatedly
By table 4 experimental result, shown, Chinese medicine composition of the present invention repeatedly medication is very little to skin irritation, with matched group there was no significant difference.
the clinical observation of embodiment 14 Chinese medicine composition of the present invention to alopecia relevant disease
The generating hair Chinese medicine composition that embodiment of the present invention 1-5 is prepared is respectively for the treatment to folliculitis decalvans, alopecia, alopecia areata and milphae, and its Therapeutic Method and therapeutic outcome are as shown in the table:
The clinical observation of table 5 Chinese medicine composition of the present invention to alopecia relevant disease
As can be seen from Table 5, adopt the embodiment of the present invention 2 and the preparation-obtained Chinese medicine composition of embodiment 5 for the treatment of folliculitis decalvans, alopecia, alopecia areata, milphae, cure rate all over 90%. this show to adopt Chinese medicine composition of the present invention to there is good therapeutic effect to such disease, wherein the preparation-obtained Chinese medicine composition effect of the embodiment of the present invention 3 is best, its to the cure rate of the diseases such as folliculitis decalvans, alopecia, alopecia areata, milphae all over 95%.
Claims (2)
1. the Chinese medicine composition of a generating hair, it is characterized in that, described Chinese medicine composition is comprised of following component: basyleaves 15-25 part, Arillus Longan shuttle 12-18 part, Ramulus Salicis Babylonicae 12-18 part, Herba Cynomorii 3-6 part, Radix Asparagi 8-12 part, Radix Et Caulis Acanthopanacis Senticosi 8-12 part, Folium Ginkgo 3-6 part, Herba Commelinae 10-20 part, Folium Nelumbinis 8-12 part, orange peel 8-12 part, Folium Eriobotryae 8-12 part, Fructus Dispyroris Loti 5-15 part.
2. Chinese medicine composition as claimed in claim 1, it is characterized in that, described Chinese medicine composition is comprised of following component: 20 parts of basyleaves, 15 parts, Arillus Longan shuttle, 15 parts of Ramulus Salicis Babylonicae, 5 parts of Herba Cynomoriis, 10 parts of Radix Asparagi, 10 parts of Radix Et Caulis Acanthopanacis Senticosis, 5 parts of Folium Ginkgos, 15 parts of Herba Commelinaes, 10 parts, Folium Nelumbinis, 10 parts of orange peels, 10 parts of Folium Eriobotryaes, 10 parts of Fructus Dispyroris Loti.
3. as the Chinese medicine composition as described in arbitrary in claim 1-2, it is characterized in that, it is mixture, unguentum, liniment, gel.
4. the purposes of Chinese medicine composition as claimed in claim 1 or 2 in preparing generating hair medicine.
5. the purposes of Chinese medicine composition as claimed in claim 1 or 2 in preparing hair growth folliculitis, alopecia, alopecia areata or milphae medicine.
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| CN103239537A (en) * | 2013-05-30 | 2013-08-14 | 崔新明 | Chinese medicine composition for growing and developing hair and application thereof |
| CN104414931A (en) * | 2013-09-09 | 2015-03-18 | 青岛锦涟鑫商贸有限公司 | Improved traditional Chinese medicine shampoo |
| CN105582511A (en) * | 2016-01-25 | 2016-05-18 | 英丽华 | Hair-growing traditional Chinese medicine composition as well as preparation method and application thereof |
| CN105796751A (en) * | 2016-04-05 | 2016-07-27 | 张蔓莉 | Preparation method of hair-blacking prescription |
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| CN1058901A (en) * | 1990-08-16 | 1992-02-26 | 于宗亮 | The prescription of hair stimulator and manufacture method |
| CN1399997A (en) * | 2001-08-02 | 2003-03-05 | 赵艳杰 | Liquid method for growing hair |
| CN1795006A (en) * | 2005-04-11 | 2006-06-28 | 孟悦华 | Hair regrowth agent |
| CN101352516A (en) * | 2008-09-10 | 2009-01-28 | 周小萍 | Safety high-efficient pilatory and preparation method |
| CN101897898A (en) * | 2010-08-17 | 2010-12-01 | 徐建华 | Chinese medicinal multifunctional hair-growth and health-care medicinal liquor and preparation method thereof |
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| CN1058901A (en) * | 1990-08-16 | 1992-02-26 | 于宗亮 | The prescription of hair stimulator and manufacture method |
| CN1399997A (en) * | 2001-08-02 | 2003-03-05 | 赵艳杰 | Liquid method for growing hair |
| CN1795006A (en) * | 2005-04-11 | 2006-06-28 | 孟悦华 | Hair regrowth agent |
| CN101352516A (en) * | 2008-09-10 | 2009-01-28 | 周小萍 | Safety high-efficient pilatory and preparation method |
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