CN103080763A - Magnetic resonance imaging system, computer system, and computer program product for sending control messages to an anesthesia system - Google Patents
Magnetic resonance imaging system, computer system, and computer program product for sending control messages to an anesthesia system Download PDFInfo
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Abstract
A magnetic resonance imaging system (500) comprising: a magnet (502) for generating a magnetic field; a radio frequency system (516) for acquiring magnetic resonance data; a magnetic field gradient coil (510) for spatial encoding of the magnetic spins of nuclei within the imaging volume; a magnetic field gradient coil power supply (512) for supplying current to the magnetic field gradient coil; an anesthesia system interface (532) for sending control messages to an anesthesia system (524) for controlling the delivery of inhalation gases to a subject and a computer system comprising a processor (534) and a memory (538, 540), wherein the memory contains instructions (542, 544, 546, 548, 550, 552) for execution by the processor, wherein execution of the instructions causes the processor to: control (100, 200, 300, 400) the operation of the magnetic resonance imaging system to acquire magnetic resonance data, and to send (102, 202, 302, 402) control messages to the anesthesia system via the anesthesia system interface.
Description
Technical field
The present invention relates to magnetic resonance imaging, in particular to the synchro control to magnetic resonance imaging system and anesthesiaing system.
Background technology
Measurement is in response to causing the O2(hyperoxia) and the CO2(hypercapnia) magnetic resonance (MR) of breathing challenge (RC) of the level rise can understand large-scale physiological parameter in depth, for example blood and tissue oxygenation, vascular is ripe and function, tumor hypoxia and Clinical study of cerebrovascular reactivity.These parameters for example select, plan in (dosage) and the monitoring to have important effect at tumor therapy in oncology studies.In those experiments, the patient sucks the air be rich in O2 and/or CO2, and this causes depending on dissolved oxygen amount in the maturation of vascular and oxygen function and/or blood plasma and the tissue and to the adjusting of blood flow, volume and oxygenation.As response, the MR relaxation rate and thereby the MR contrast respectively the impact of tissue and the magnetic characteristic of blood and relaxation parameter is changed according to this challenge that (oxygenated blood is the T2* of diamagnetic increase, dissolved oxygen DO in blood and the tissue is the paramagnetic T1 that reduces, the inflow that accelerates in the CO2 horizontal period that strengthens reduces T1 artificially, etc.).
Journal of writings " Selective Reduction of Blood Flow to White Matter During Hypercapnia " Stroke at Mandell etc., among the DOl:10.1161/STROKEAHA.107.501692, with the automatic gas sequence carbon dioxide state is being replaced between end-tidal high pressure and low pressure during the BOLD magnetic resonance acquisition.
In paper " MR compatible ventilator for small animals:computer controlled ventilation for proton and noble gas imaging " Magnetic Resonance Imaging18 (2000) 753-759 of L.W.Hedlund etc., mentioning can be by so that ventilator triggers imaging on one's own initiative or by coming synchronized ventilation and imaging so that imaging triggers ventilator.
Summary of the invention
The present invention provides magnetic resonance imaging system, computer system in independent claims, and computer program.Embodiment provides in the dependent claims.
The difficult point of current breathing challenge (RC) process is that conventional scheme comprises one or more MR scannings, it is sucking the O2 of variation the patient, CO2 composition or suck when other suck gases is carried out, and is also referred to as RC, namely separates fully with the MR unit and is independent of its controlled unit.In other words, radiology expert and anesthetist approve of specific RC agreement (for example, 1 minute normal air, 4 minutes oxygen, 2 minutes normal air).Then, manually synchronously (respectively) MR scanning with suck sending and mixing of gas, and manually the accurate timing that scans with respect to MR of the breathing scheme in fact used of record with for after a while MR data analysis.
When MR scanning not with the RC agreement ideally synchronously the time problem produced, perhaps vice versa, for example owing to:
Misunderstanding between the anesthetist in the technician of outside, MR room and radiology expert and the MR room,
Regularly unreliable,
The patient sucks the leakage of the sucting mask of applied potpourri via it, perhaps
The aftertreatment failure is when (manually) RC agreement record is lost or be wrong.
For example, at the O2 to increasing, CO2 send the MR response of level parametric description (also namely, in time the MR signal or relaxation constant in time) disclose in the situation of mark of tumour physiological parameter (oxygenation, vascular reactivity).For this reason, signal model is fitted to a series of images that records.But experimentally or based on organizing gap model to obtain this model.The numerical fitting program needs suitably initialization model parameter.These are as the starting value of the iterative approximation of actual parameter.Depend on algorithm, fitting result for example, is transferred in the RC of mistake agreement in the situation of MR processing for the wrong initialization of fitting parameter, will be more responsive or more insensitive.For example, the anesthetist uses the RC agreement to the patient, and it comprises breathe air/carbogenes/air (carbogenes is the combination of O2 and CO2) of 1/4/2 minute.After a while, during data analysis, radiology expert or MR technician are with RC agreement (2/4/1 minute) the typing post-processing module of mistake (obscuring of typing error, wrong report, two " air " periods, etc.).
One embodiment of the present of invention are the communication link modules between MR environment and RC environment, its substituted between MR and the RC operator " manually " communication with:
Ideally synchronously (respectively) MR scanning and breathing challenge
Guarantee the Accurate Analysis of MR data (for example, is fitted to the suction During at signal model
In the situation of a series of dynamic images of record, this major requirement about challenge when begin/
The cognition that changes/finish).
O2 and CO2 are breathed the phenomenal growth of interest of MR imaging during the challenge and especially be still to increase in oncology.The routine " manually " of breathing and MR scan protocols is synchronously especially difficult in the MR environment, and the communication between MR operator and the RC operator (anesthetist) is easy to misunderstand, and this is converted to the analysis of MR data and the systematic error in the explanation.Synchronously and the automatically use of communication link has overcome these problems and the best of guaranteeing to test and the use of robust between MR and the RC environment, and thereby will improve significantly this effective diagnostic tool.The Realization of Product mode of oxygen or CO2 Contrast-enhanced MRI is so that be used for two environment synchronously being mounted at least necessity with some devices of guaranteeing robustness (user is independent).This comprises in the present invention.
" computer-readable recording medium " that uses in this article is that can store can be by any storage medium of the instruction of the processor of computing equipment operation.This computer-readable recording medium is computer-readable permanent storage media.This computer-readable recording medium is tangible computer-readable medium also.In certain embodiments, computer-readable recording medium also may be able to store can be by the data of the processor access of computing equipment.The example of computer-readable recording medium includes but not limited to: floppy disk, magnetic hard drive, solid state hard disc, flash memory, USB finger-like driver, random access (RAM) storer, read-only (ROM) storer, CD, magneto-optic disk, and the register file of processor.The example of CD comprises compact disk (CD) and DVD (DVD), for example CD-ROM, CD-RW, CD-R, DVD-ROM, DVD-RW or DVD-R dish.The term computer readable storage medium storing program for executing also relates to can be by the various types of recording mediums of computer equipment via network or communication link access.For example, can be by modulator-demodular unit, fetch data via the Internet or via LAN (Local Area Network).
Computer memory is the example of computer-readable recording medium.Computer memory is any storer that processor can directly be accessed.The example of computer memory includes but not limited to: RAM storer, register and register file.
Computer memory device is the example of computer-readable recording medium.Computer memory device is any non-volatile computer-readable recording medium.The example of computer memory device includes but not limited to: hard disk drive, USB finger-like driver, floppy disk, smart card, DVD, CD-ROM, and solid state hard disc.Also computer memory or vice versa of computer memory device in certain embodiments.
" processor " that uses in this article comprises can working procedure or the electronic unit of machine-executable instruction.The processor that should be interpreted as to comprise more than of mentioning to the computing equipment that comprises " processor ".The term computing equipment also should be interpreted as relating to set or the network of the computing equipment that comprises separately processor.The instruction that a lot of programs have by may within the same computing equipment or even a plurality of processors that may be distributed on a plurality of computing equipments carry out.
MR data is defined in during the MRI scan measurement result by the radiofrequency signal of atomic spin emission by the antenna record of magnetic resonance device in this article.Magnetic resonance imaging (MRI) image is defined as reconstruction two or the three-dimensional visualization of the anatomical data that comprises within the magnetic resonance imaging data in this article.Can carry out with computing machine that this is visual.
In one aspect, the invention provides a kind of magnetic resonance imaging system and comprise magnet, this magnet is suitable for generating the magnetic field of magnetic spin that is positioned at the nuclear of the object within the imaging volume for orientation.This magnetic resonance imaging system also comprises radio system, and this radio system is used for acquisition of magnetic resonance data.This radio system comprises radio-frequency (RF) transceiver, and this radio-frequency (RF) transceiver is suitable for being connected with radio-frequency coil.As using in this article, radio-frequency (RF) transceiver also can relate to independent radiofrequency launcher and receiver.This radio-frequency coil is the independent coil that transmits and receives also.This magnetic resonance imaging system also comprises magnetic field gradient coils, and this magnetic field gradient coils is used for space encoding is carried out in the magnetic spin within this imaging volume and nuclear.This magnetic resonance imaging system also comprises the magnetic field gradient coils power supply, and this magnetic field gradient coils power supply is used for providing electric current to this magnetic field gradient coils.This magnetic resonance imaging system also comprises the anesthesiaing system interface, and it is suitable for transmitting control message to anesthesiaing system.
" anesthesiaing system " that uses in this article comprises the system or the device that flow and be suitable for this gas is mixed that is suitable for controlling the gas that offers object.Although used the term anesthesiaing system, this does not also mean that the gas that uses for carrying out anesthesia.Anesthesiaing system is used for control to the gas delivery of the suction gas of object.For example can control the concentration of oxygen and/or carbon dioxide.Use wording " anesthesiaing system " to be because anesthesiaing system is supervised by the anesthesia expert in theory.
Magnetic resonance imaging system also comprises the computer system that comprises processor and storer.Storer comprises for the instruction by the processor operation.The operation of instruction is so that this processor is carried out the step of the operation of controlling magnetic resonance imaging system with acquisition of magnetic resonance data.Computer system is in essence with the control system that acts on magnetic resonance imaging system.The operation of instruction further requires processor to carry out the step that transmits control message to this anesthesiaing system via the anesthesiaing system interface.This computer system is in essence also with the control system that acts on anesthesiaing system.This embodiment is especially favourable, because this computer system is with acting on magnetic resonance imaging system and being used for both control system of anesthesiaing system.This permission is controlled more accurately to two kinds of devices, and allows more synchronously their function.This is so that anesthesiaing system can be used in the breathing challenge study of using magnetic resonance imaging system.By so that two kinds of equipment of computer system control, the MR data that can be used for making up magnetic resonance image (MRI) or other reconstructions may be relevant more nearly with the breathing challenge of being carried out by anesthesiaing system.
In another embodiment, computer memory comprises the pulse train for the collection of planning MR data.The timing planning of instruction group or the operation that is used for the control magnetic resonance imaging system such as " pulse train " used in this article.The operation of magnetic resonance imaging system is controlled in this instruction according to pulse train.Storer comprises the gas sequence, and it is used for planning to be delivered to object with the control for the gas componant of breathing by anesthesiaing system during magnetic resonance data acquisition.This instruction comes to transmit control message to anesthesiaing system according to the gas sequence.
In another embodiment, the anesthesiaing system interface also is suitable for from anesthesiaing system receiver gases sensing data." gas sensor data " used in this article comprise within the anesthesiaing system for detection of being sucked by object or the measurement result of the sensor of the characteristic of breath.This gas sensor data is included in the time correlation gas concentration in object suction and/or the breath.This gas sensor data be time correlation according to the MR data of pulse train.In this embodiment, this is especially favourable, relies on research fully to the air-flow of object because be alternative in, and can measure actual suction or breath with the gas sensor that gas sensor data is provided.This allows any breathing challenge process very accurately relevant with pulse train.This allows relevant with pulse train very accurately is correlated with from the MR data magnetic resonance image (MRI) that generates and this part of breathing the challenge process.
In another embodiment, measured gas concentration comprises oxygen concentration in gas.
In another embodiment, measured gas concentration comprises gas concentration lwevel in gas.
In another embodiment, measured gas concentration comprises nitrogen gas concn in gas.
In another embodiment, instruction is also so that this processor executive basis is breathed the step that the challenge algorithm comes the analysis of magnetic resonance data.The breathing challenge algorithm that uses in this article comprises the statistical analysis of carrying out MR data in order to infer the algorithm of the effect of breathing the challenge agreement.During being contained in magnetic resonant imaging examination, the breathing challenge protocol package of using in this article changes the characteristic that object sucks gas.Carry out the initialization of breathing the challenge protocol algorithm according to gas sensor data.The statistical analysis of MR data is relevant with timing from the data of gas sensor data in essence.For example, if the carbon dioxide level that object sucks in the gas improves, when measuring the carbon dioxide level of raising in the face shield at object, breathing the challenge algorithm can be associated with beginning so.
In another embodiment, the operation of instruction is also so that processor is carried out the step that gathers the MR data that can be resorted to tissue oxygenation relevant contrast image.This can be for example by measuring so-called T2* or T1, perhaps by indicate T2*-or T1-weighted image realize.The operation of instruction is also so that processor is carried out the step that MR data is redeveloped into tissue oxygenation relevant contrast image.The operation of instruction is also so that processor is carried out the step of determining the tissue oxygenation set of measurements.For example, can pass through T2* or T1 value, perhaps from T2*-or T1-weighted image determine tissue oxygenation tolerance.The tissue oxygenation set of measurements measures to make up by the tissue oxygenation of determining the oxygenate test volume in each tissue oxygenation relevant contrast image.Breathe the challenge algorithm and come the analysis of magnetic resonance data by the statistical analysis of carrying out at least the subgroup of tissue oxygenation set of measurements.Determine this subgroup according to gas sensor data.
In another embodiment, during the collection of MR data, calculate each tissue oxygenation tolerance.This instruction is also so that the horizontal set of measurements of processor executive basis tissue oxygen is come the step of corrected impulse sequence and/or gas sequence.Can revise this gas sequence by the effect of measuring tissue oxygen level tolerance.For example, if detect remarkable change in the tissue oxygen level, can stop so experiment and the gas sequence can be modified to so that the normal air of subject breathed.The contrast that depends on the horizontal set of measurements of tissue oxygen that detects in magnetic resonance image (MRI) can the corrected impulse sequence.For example, can revise repetition time and the quantity of the echo of measuring for T2*.
In another embodiment, the operation of instruction is also so that processor is carried out the step that gathers the MR data that can be resorted to the vascular reactivity contrast image.This can for example can be resorted to the MR data of T1 weighting or T2*-weighted image by collection or finish by measuring T2* or T1.This instruction is also so that processor is carried out the step that MR data is redeveloped into the vascular reactivity contrast image.This vascular reactivity contrast image can for example be T1 weighting contrast image.The operation of instruction further requires processor to carry out the step of determining the vascular reactivity set of measurements.This vascular reactivity set of measurements makes up by the vascular reactivity level of determining the vascular reactivity test volume in each vascular reactivity contrast image.
Be the use of gas with various for the difference of the RC agreement that gathers the MR data that can be resorted to vascular reactivity contrast image or tissue oxygenation relevant contrast image.The analysis of MR data is identical or similar.Information about oxygenate and vascular reactivity can be from T1, T2 or T2* weighted image or T1, T2 or the acquisition of T2* value.
Breathe the challenge algorithm and come the analysis of magnetic resonance data by the statistical analysis of carrying out at least the subgroup of vascular reactivity set of measurements.Determine this subgroup according to gas sensor data.Gas sensor data can be for example be used for determining carbon dioxide or for example the concentration of carbogenes when improve.This can be used for determining when to carry out statistical analysis.
In another embodiment, during the collection of MR data, calculate each vascular reactivity tolerance.This instruction is also so that processor executive basis vascular reactivity set of measurements is come the step of corrected impulse sequence and/or gas sequence.Pulse train can be modified to so that its contrast changes to optimize the speed during contrast and the image data.For example, can change repetition time and the quantity of the echo that uses.Also can revise the gas sequence according to vascular reactivity set of measurements herein, if for example vascular reactivity tolerance has reached certain contrast level in the vascular reactivity contrast image, can stop so experiment, and the gas sequence can finish and can be corrected for so that object begins eupneic air again.
In another embodiment, the operation of instruction is also so that processor executive basis gas sensor data is come the step of corrected impulse sequence and/or gas sequence.If object does not have suction or the gas concentration of the expection of breathing out, can revise so the gas sequence to proofread and correct this air.Also can be by coming the corrected impulse sequence with new gas sensor data.For example, the gaseous mixture of expection if object breathes no more, the timing of pulse train can be delayed a period of time so.
In another embodiment, pulse train is many Gradient echoes sequences.This embodiment is favourable, because this pulse train can be used for gathering the image with different T2* weighting contrasts, and is used for from this image sets calculation in quantity T2* value.
In another embodiment, magnetic resonance imaging system comprises anesthesiaing system.
In another aspect, the invention provides a kind of computer system for the control magnetic resonance imaging system.This computer system comprises the processor for operating instruction.This computer system is connected with magnetic resonance imaging system.This computer system is connected with the anesthesiaing system interface that is used for transmitting control message to anesthesiaing system.This computer system also can transmit control signal to magnetic resonance imaging system.The operation of machine readable instructions is so that this processor is carried out the step of the operation of control magnetic resonance imaging system.The operation of machine readable instructions is also so that this processor is carried out the step that transmits control message to anesthesiaing system via the anesthesiaing system interface.
In another aspect, the invention provides a kind of computer program that comprises by the machine readable instructions of the processor of computer system operation.This computer program also is stored in the machine readable instructions on the computer-readable recording medium.This computer system is connected with magnetic resonance imaging system.This computer system is connected with the anesthesiaing system interface that is used for transmitting control message to anesthesiaing system.The operation of machine readable instructions is so that this processor is carried out the step of the operation of control magnetic resonance imaging system.The operation of machine readable instructions is also so that this processor is carried out the step that transmits control message to anesthesiaing system via the anesthesiaing system interface.
Description of drawings
To only by way of example and with reference to figure the preferred embodiments of the present invention be described hereinafter, wherein:
Block scheme shown in Fig. 1 has illustrated the embodiment according to the inventive method;
Block scheme shown in Fig. 2 has illustrated another embodiment according to the inventive method;
Block scheme shown in Fig. 3 has illustrated another embodiment according to the inventive method;
Block scheme shown in Fig. 4 has illustrated another embodiment according to the inventive method;
Fig. 5 shows the magnetic resonance imaging system according to the embodiment of the invention;
Fig. 6 shows according to another embodiment of the present invention magnetic resonance imaging system; And
Fig. 7 illustrates for MR data and the synchronous correct timing of breathing challenge experiment and wrong result.
Reference numerals list
500 magnetic resonance imaging systems
502 magnets
504 imaging volumes
506 objects
508 object supporters
510 magnetic field gradient coils
512 magnetic field gradient coils power supplys
514 radio-frequency coils
516 radio-frequency (RF) transceiver
518 face shields
520 inlet tubes
522 outlets
524 anesthesiaing systems
526 inlet gas sensors
528 exit gas sensors
530 computer systems
532 hardware interfaces
534 processors
536 user interfaces
538 computer memorys
540 computer memory devices
542 magnetic resonance imaging system control modules
544 anesthesiaing system control modules
546 breathe the challenge protocol algorithm
548 image reconstruction module
550 gas sequence correcting modules
552 pulse train correcting modules
554 pulse trains
556 gas sequences
558 gas sensor data
560 MR data
The magnetic resonance imaging image of 562 transverse plane relaxation time weightings
600 function chards
602 anesthetic gaseses
604 air amounts
606 communication link modules
608 anesthetists
610 operators
612 principal computers
614 clinical protocols
616 results
618 sweep parameters
620 scan control modules
The control of 622 resonance
624 magnetic resonance raw data
626 rebuild module
628 reconstruction parameters
630 magnetic resonance image (MRI)
632 aftertreatments and analysis module
The 634 real challenge agreements of breathing
636 feedback level
638 monitoring of respiration modules
640 in response to the ventilation of breathing the challenge agreement
642 challenges
The challenge agreement is regularly breathed in 644 scannings
646 synchronization modules
648 breathe the challenge agreement
650 breathe the challenge control module
652 control commands
700 correct timings
The timing of 702 mistakes
The breathing challenge agreement of 704 expections
The breathing challenge agreement of 706 reality
The breathing challenge agreement of 708 reality
712 frames
714 frames
716 zones
718 Δ R2* figure
720 Δ R2* figure
Embodiment
The element by similar numbering in these figure is identical element or carries out identical function.Needn't be discussed in figure after a while if the element function of before having discussed is identical.
Block scheme shown in Fig. 1 has illustrated the embodiment according to the inventive method.The operation of control magnetic resonance imaging system is with acquisition of magnetic resonance data in step 100.In step 102, via the anesthesiaing system interface control message is sent to anesthesiaing system.
Block scheme shown in Fig. 2 has illustrated the embodiment according to other method of the present invention.The operation of control magnetic resonance imaging system is so that acquisition of magnetic resonance data in step 200.In step 202, via the anesthesiaing system interface control message is sent to anesthesiaing system.In step 204, come the analysis of magnetic resonance data according to breathing the challenge algorithm.
Block scheme shown in Fig. 3 has illustrated another embodiment according to the inventive method.The operation of control magnetic resonance imaging system is so that acquisition of magnetic resonance data in step 300.In step 302, via the anesthesiaing system interface control message is sent to anesthesiaing system.In step 304, gather the MR data that can be resorted to tissue oxygenation relevant contrast image.This MR data comprises the MR data of T2* information.In step 306, determine the tissue oxygenation set of measurements.Step 306 can comprise MR data is redeveloped into tissue oxygenation relevant contrast image.And in step 308, come corrected impulse sequence and/or gas sequence according to the tissue oxygenation group at last.
Block scheme shown in Fig. 4 has illustrated another embodiment according to the inventive method.The operation of control magnetic resonance imaging system is so that acquisition of magnetic resonance data in step 400.In step 402, via the anesthesiaing system interface control message is sent to anesthesiaing system.In step 404, gather the MR data that can be resorted to the vascular reactivity contrast image.In step 406, determine the vascular reactivity set of measurements.Step 406 can comprise MR data is redeveloped into the vascular reactivity contrast image.In step 408, come corrected impulse sequence and/or gas sequence according to the vascular reactivity set of measurements.
Fig. 5 shows the magnetic resonance imaging system 500 according to the embodiment of the invention.This magnetic resonance imaging system comprises magnet 502, and it is used for the position of the magnetic spin within the imaging volume 504 of the object 506 within the directed thorax that is positioned at magnet 502.Magnet 502 is depicted as the magnet of right cylinder type, its have pass central authorities thorax to hold object.Yet, also can use the magnet of other kinds, for example so-called open or toroidal magnet.Object 506 is depicted as and reposes on object supporter 508.Within the thorax of magnet 502 is magnetic field gradient coils 510.This magnetic field gradient coils 510 is connected with magnetic field gradient coils power supply 512.Magnetic resonance imaging system typically has three independent coil systems.Gradient coil 510 and gradient coil power supply 512 are intended to the gradient coil of the standard that represents.On imaging volume 504 is radio-frequency coil 514.This radio-frequency coil 514 is connected with radio-frequency (RF) transceiver 516.Radio-frequency coil 514 is used for handling the orientation of the magnetic spin within the imaging volume 504 with the combination of radio-frequency (RF) transceiver 516, and also is used for coming acquisition of magnetic resonance data by measuring the radio signal that receives.
Fig. 6 shows the embodiment according to the functional block diagram 600 of the magnetic resonance imaging system 500 of the embodiment of the invention.In Fig. 6, discussed the control aspect of system 600.Have anesthesiaing system, its representative is to the control of anesthetic gases 602.Anesthesiaing system 504 receives air amount 604 from this anesthetic gases.Anesthesiaing system 524 control gaseous mixture to the flowing of face shield 518, and receive them via exhale tube 522 via tail pipe 520.Face shield 518 is on the patient 506 within the magnetic resonance system 500.Anesthesiaing system 524 is via communication link module 606 receipt messages and send message to principal computer 612.Magnetic resonance imaging system operator 610 is depicted as the clinical protocol 614 that control sends to principal computer 612.This principal computer 612 also bears results 616 from agreement, and this result can be displayed to operator 610 at principal computer 612.Principal computer sends sweep parameter 618 to scan control module 620.This scan control module 620 is equal to the magnetic resonance imaging system control module 542 of Fig. 5.Scan control module 620 transmits control signal 622 to magnetic resonance imaging system 500.Original magnetic resonance imaging data 624 is sent to image reconstruction module 626 by magnetic resonance imaging system 500.Reconstruction module 626 is equal to the image reconstruction module 548 of Fig. 5.Magnetic resonance raw data 624 is equal to the MR data 560 of Fig. 5.Principal computer 612 sends reconstruction parameter 628 to rebuilding module 626.
Fig. 6 has summarized and has been used for the mechanism that challenge is breathed in the MR monitoring.Conventionally, its comprise similar separate fully by MR(radioactive ray expert, MR technician) 610 and RC608 operator (anesthetist) respectively independently MR and the RC environment of control.
The RC environment comprises anesthesiaing system 524, it comprises following any composition: sucks gas 602, is used for anaesthetize delivery apparatus 520,522 that potpourri is sent to patient 506, via breathing out 520 and suck 522 pipes and transmit to the patient and from the patient and suck and delivery apparatus, the monitoring of exhalation air sucks and sensor, the absorption unit of dioxide carbon of the gas level of exhale tube, prevent from again breathing that the device of exhalation air, optimization sent the demand valve of the consumption of anesthesia, etc.Anesthesiaing system has been supplied to suction gas, outside and this system that for example carbogenes, CO2, pure oxygen or from other gases of gas feed unit, this anesthesiaing system are placed in MR cover room usually further can " normally " space air introducing suction potpourri.This suction potpourri is delivered to the patient via tail pipe 520 and face shield 518.The exhalation air is sent to cleaning system by independent exhalation 522 pipes from the patient.This anesthesiaing system is manually controlled by the anesthetist usually, the anesthetist further will suck and/or the composition of exhalation air in unusually convey to MR operator 610 so that consider should be unusual in aftertreatment after a while.
The MR environment comprises the MR scanner 500 by radiology expert 610 or MR technician's operation, and this radiology expert 610 or MR technician select according to clinical problem or even optimization scan protocols.Selected scan protocols 614 is sent to the scan control module 620 of control MR machine 500.This of scan protocols regularly (for example, dynamic quantity and length in dynamic scan) need to RC agreement 648 synchronously (for example, MR and RC agreement need to begin simultaneously, and the number needs of dynamic image will suitably represent the variation at experimental session MR signal).The data 624 that gather are sent to rebuilds module 626, rebuilds the data of being selected by the MR operator based on information and the demand determined by scan protocols 614.
Aftertreatment and analysis module 632 carry out some processing to image 630 (for example, motion correction, relaxation are measured, data filtering, etc.) and to the quantitative test of response (for example, oxygen between respiratory period to the intensity of signal intensity and dynamicly determine).Can be manually with the timing of scanning and to the aftertreatment of return data with analyze and synchronously (for example breathe agreement 648, analysis module need to be about the knowledge of baseline and RC data to compare in the statistics test, the signal model that is used for the numerical fitting data depends on the timing of RC agreement, etc.).
One embodiment of the present of invention are communication link modules 606, its robotization and the synchronously communication between MR scanning and processing/analysis environments and RC environment.This has substituted anesthetist 608 control action.He further need to supervise the patient and be used for possible experiment safety interruption.
In a preferred embodiment, the communication link module is included in synchronization module 646, the breathing challenge control module 650 of more describing in detail in the following paragraph, and monitoring of respiration module 638.This communication link is driven by the scanning management environment on the MR principal computer, and the anesthesiaing system 524 of control MR compatibility.
In the embodiment shown in fig. 6, MR operator 610 selects certain process according to given clinical problem.This comprise the RC648((that will be employed each) type of gas and regularly).Synchronization module is so that RC is suitable for MR scanning and vice versa:
Sending and composition of the length of its capable of regulating MR scanning and specific suction potpourri: it is guaranteed to send during the MR image acquisition and is not changed, and it tests both synchronization length and start time for MR and RC, etc.
If necessary, it (for example revises sweep parameter according to particular challenge, it can select the insensitive imaging protocol of convection current amount using in the suction potpourri situation that blood flow is had appreciable impact, but its optimal imaging agreement is to optimize contrast with respect to the suction potpourri of being sent).
MR agreement and the RC agreement through optimizing to principal computer and breathing that then synchronization module 646 sends respectively through optimizing are challenged control module.This RC agreement also is provided to aftertreatment/analysis module to be used for after a while processing reconstructed data.Synchronization module may be implemented as the software of carrying out at the scanner main frame.
Breathe challenge control module 650 and comprise computer-readable recording medium, it receives RC agreement 648 and converts thereof into programming instruction 652 with control anesthesiaing system 524 from synchronization module 646.When processor moved, at least some valves of its control anesthesiaing system were automatically to select specific anesthetic gases and to adjust required gaseous tension, flow and cabin according to the RC agreement.Itself thus substituted anesthetist's manual control.In certain embodiments, breathe the challenge control module and be integrated into or be attached to anesthesiaing system.
Monitoring of respiration module 638 reads the monitoring sensor of anesthesiaing system 524, and this sensor provides patient respiratory signal (for example, sucking suction and the exhalation pressure in cabin).The patient respiratory signal is at first by graphical demonstration and/or be expressed in parametric description.This expression can be provided by the LCD display that is integrated in the monitoring of respiration module, and is for security reasons monitored by the anesthetist.Allow the second expression be sent to MR principal computer display to be used for by the extra supervision of MR operator but useful (be similar to the ECG signal and how be indicated on routinely the principal computer display).The more important thing is, reflect that the actual patient breath signal that the true breathing of challenging is responded changes the potential correction of the RC agreement of using in aftertreatment after a while.This RC agreement thereby be updated and be sent to the after a while processing that aftertreatment/analysis module is used for the MR data.For example, after experiment is carried out half, remove in the situation of face shield the patient, must correspondingly shorten the RC agreement and the signal model that are used by analysis module.The monitoring of respiration module also may be implemented as be included on the computer-readable recording medium by with the instruction of MR principal computer 612 operations of the sensor communication of anesthesiaing system, perhaps it is integrated or is attached to anesthesiaing system, send monitoring result to the MR principal computer, perhaps it is the part of the control of breathing unit that is connected with the RC environment with MR, etc.
Fig. 7 is divided into two parts.First 700 illustrates for MR data and breathes the synchronous correct timing 700 of challenging.Second portion 702 illustrates the analysis of magnetic resonance imaging data and breathes regularly wrong between the timing of challenge.Have timeline 704 in two parts 700,702, it shows the expection timing of breathing the challenge agreement.In this breathing challenge agreement, four minutes carbogenes gas of one minute air of subject breathed is two minutes air then.Timeline 706 shows the actual breathing challenge agreement of carrying out with correct timing 700, and timeline 708 shows the actual breathing challenge agreement of carrying out when timing is asynchronous.Timeline 706 is consistent with timeline 704.Yet timeline 708 is inconsistent with timeline 704.
The initial breathing of object two minutes rather than one minute air in timeline 708.Consequently object is than late one minute breathing carbogenes gas of expection.The chart that shows the R2* variation under this timeline, timeline all provides take second as unit in both cases.In the first 700 of figure, frame 712 indications are used for the data point 712 of execution analysis.In the second portion 702 of figure, chart frame 714 indications are used for the data of statistical analysis.Chart in second portion 702 shows two regularly not right zones 716.Data are used for rebuilding Δ R2* response diagram 718 in first 700, and it is used for illustrating the tumour figure of meningioma.R2* is the inverse of T2*.Δ R2* response diagram shows the chart that R2* changes.For the above-mentioned agreement that reads.Use the timing of displacement, same image 720 is calculated in the timing 702 of mistake in using.Image 718 and 720 the contrast that relatively shows in the image 718 are better than in 720.
Fig. 7 shows the mistake reception and registration/false sync of RC and MR data analysis agreement to the impact (right hurdle) of tumour response diagram and model.Left hurdle has been described and has been used the correct result who arranges.This response diagram is based on the statistics test that compared with last 2 minutes carbogenes challenge the period of baseline breathing.The false sync of breathing challenge and MR data analysis causes " more black " figure, because response amplitude is owing to test is compared base-line data and underestimated with carbogenes " mistake " data between respiratory period.Owing to the beginning of carbogenes challenge and the wrong initialization of end point, model can not with the match of data phase.
Although illustrate in detail and described the present invention in the drawings with in the aforementioned description, this diagram and description will be considered to illustrative or exemplary, rather than restrictive; The invention is not restricted to the disclosed embodiments.
Those skilled in the art are when putting into practice desired invention, and the research by to figure, disclosure and appended claims is appreciated that and realizes other modification to disclosed embodiment.In the claims, wording " comprises " does not get rid of other elements or step, and indefinite article " " or " one " do not get rid of a plurality of.Several functions putting down in writing in the claims can be realized in single-processor or other unit.This of some measure of record only has the fact in mutually different dependent claims, do not represent and the combination of these measures can not be used.Computer program can be stored/distributed on the suitable medium, for example provide with other hardware or as optical storage medium or the solid state medium of other hardware parts, but it also may be with other formal distributions, for example via the Internet or other wired or wireless communication systems.Any Reference numeral in the claims should not be construed as the restriction to scope.
Claims (12)
1. a magnetic resonance imaging system (500) comprising:
Magnet (502), it is suitable for generate being used for the magnetic field of magnetic spin that orientation is positioned at the nuclear of the object within the imaging volume (504);
Radio system (516), it is used for acquisition of magnetic resonance data, and wherein, described radio system comprises the radio-frequency (RF) transceiver (516) that is suitable for being connected to radio-frequency coil (514);
Magnetic field gradient coils (510), it is used for space encoding is carried out in the described magnetic spin of the nuclear within the described imaging volume;
Magnetic field gradient coils power supply (512), it is used for providing electric current to described magnetic field gradient coils;
Anesthesiaing system interface (532), it is suitable for transmitting control message to anesthesiaing system (524); And
The computer system that comprises processor (534) and storer (538,540), wherein, described storer comprises for the instruction (542 by described processor operation, 544,546,548,550,552), wherein, the operation of described instruction is so that described processor is carried out following steps:
Control the operation of (100,200,300,400) described magnetic resonance imaging system with acquisition of magnetic resonance data,
Send (102,202,302,402) control message for described anesthesiaing system via described anesthesiaing system interface, and
Wherein, described computer memory comprises the pulse train (554) for the described collection of planning MR data (560), wherein, the operation of described magnetic resonance imaging system is controlled in described instruction according to described pulse train, wherein, described storer comprises gas sequence (556), this gas sequence is used for planning and offers described object with the time control for the gas componant of breathing by described anesthesiaing system during the described collection of MR data, and wherein, described instruction comes to described anesthesiaing system transmit control message (652) according to described gas sequence.
2. as claimed in claim magnetic resonance imaging system, wherein, described anesthesiaing system interface also is suitable for from described anesthesiaing system receiver gases sensing data (558,636), wherein, described gas sensor data be included in that described object sucks and/or breath in the time correlation gas concentration, wherein, described gas sensor data is time correlation with described MR data according to described pulse train.
3. magnetic resonance imaging system as claimed in claim 2, wherein, the described gas concentration of measuring in described gas comprises with lower any: oxygen concentration, gas concentration lwevel and nitrogen gas concn.
4. magnetic resonance imaging system as claimed in claim 2 or claim 3, wherein, described instruction is also so that described processor executive basis is breathed the step that challenge algorithm (546) is analyzed (204) described MR data, wherein, carry out the initialization of described breathing challenge protocol algorithm according to described gas sensor data.
5. magnetic resonance imaging system as claimed in claim 4, wherein, the operation of described instruction is also so that described processor is carried out following steps:
-collection (304) can be resorted to the MR data of tissue oxygenation relevant contrast image;
-described MR data is redeveloped into tissue oxygenation relevant contrast image (562);
-determine (306) tissue oxygenation set of measurements, wherein, described tissue oxygenation set of measurements makes up by the tissue oxygenation tolerance of determining the oxygenate test volume in each described tissue oxygenation relevant contrast image;
Wherein, described breathing challenge algorithm is analyzed described MR data by carrying out at least to the statistical analysis of the subgroup of described tissue oxygenation set of measurements, and wherein, determines described subgroup according to described gas sensor data.
6. magnetic resonance imaging system as claimed in claim 5, wherein, during the described collection of MR data, calculate each tissue oxygenation tolerance, wherein, described instruction is also so that the horizontal set of measurements of the described tissue oxygen of described processor executive basis is revised the step of (308) described pulse train and/or gas sequence.
7. such as claim 4,5 or 6 described magnetic resonance imaging systems, wherein, the operation of described instruction is also so that described processor is carried out following steps:
-collection (404) can be resorted to the MR data of vascular reactivity contrast image (562);
-described MR data is redeveloped into the vascular reactivity contrast image;
-determine (406) vascular reactivity set of measurements, wherein, described vascular reactivity set of measurements is to make up by the vascular reactivity level of determining the vascular reactivity test volume in each described vascular reactivity contrast image;
Wherein, described breathing challenge algorithm is analyzed described MR data by carrying out at least to the statistical analysis of the subgroup of described vascular reactivity set of measurements, and wherein, determines described subgroup according to described gas sensor data.
8. magnetic resonance imaging system as claimed in claim 7, wherein, during the described collection of MR data, calculate each vascular reactivity tolerance, wherein, described instruction is also so that the described vascular reactivity set of measurements of described processor executive basis is revised the step of (408) described pulse train and/or gas sequence.
9. such as each described magnetic resonance imaging system in the claim 2 to 8, wherein, the operation of described instruction is also so that the described gas sensor data of described processor executive basis is revised the step of described pulse train and/or gas sequence.
10. magnetic resonance imaging system as claimed in claim 6, wherein, described pulse train is many Gradient echoes sequences.
11. such as each described magnetic resonance imaging system in the aforementioned claim, wherein, described magnetic resonance imaging system comprises described anesthesiaing system.
12. one kind comprises the computer program by the machine readable instructions of the processor of computer system operation, wherein, described computer system is connected to magnetic resonance imaging system, wherein, described computer system is connected to for the anesthesiaing system interface that transmits control message to anesthesiaing system, wherein, the operation of described machine readable instructions is so that described processor is carried out following steps:
The operation of control (100,200,300,400) described magnetic resonance imaging system; And
Send (102 for described anesthesiaing system via described anesthesiaing system interface, 202,302,402) control message, to be used for planning to during the described collection of MR data, offering object with the time control for the gas componant of breathing by described anesthesiaing system, and wherein, described instruction is given described anesthesiaing system transmit control message (652) according to described gas sequence.
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|---|---|---|---|
| EP10174463.9 | 2010-08-30 | ||
| EP10174463A EP2423699A1 (en) | 2010-08-30 | 2010-08-30 | Magnetic resonance imaging system, computer system, and computer program product for sending control messages to an anesthesia system |
| PCT/IB2011/053717 WO2012028997A1 (en) | 2010-08-30 | 2011-08-24 | Magnetic resonance imaging system, computer system, and computer program product for sending control messages to an anesthesia system |
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| EP (2) | EP2423699A1 (en) |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107423538A (en) * | 2016-02-16 | 2017-12-01 | 西门子保健有限责任公司 | Medical examination system |
| CN108377641A (en) * | 2016-11-08 | 2018-08-07 | 中国科学院深圳先进技术研究院 | Magnetic resonance vascular wall imaging method and equipment |
| CN111983536A (en) * | 2014-09-05 | 2020-11-24 | 海珀菲纳研究股份有限公司 | Automatic configuration of low-field magnetic resonance imaging system |
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| EP2423699A1 (en) * | 2010-08-30 | 2012-02-29 | Koninklijke Philips Electronics N.V. | Magnetic resonance imaging system, computer system, and computer program product for sending control messages to an anesthesia system |
| DE102011085399A1 (en) * | 2011-10-28 | 2013-05-02 | Siemens Aktiengesellschaft | Method for recording magnetic resonance image data using a respiratory device |
| CN103893888B (en) * | 2012-12-26 | 2017-05-24 | 北京谊安医疗系统股份有限公司 | Pulse width modulation type anesthesia machine or breathing machine |
| EP3105607B1 (en) * | 2014-02-13 | 2020-07-15 | Koninklijke Philips N.V. | Method of time-efficient 4d magnetic resonance imaging |
| WO2015126795A1 (en) * | 2014-02-18 | 2015-08-27 | The Board Of Regents Of The University Of Texas System | Systems and methods for gas mixture delivery to humans inside an mri scanner |
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| GB2527538A (en) | 2014-06-25 | 2015-12-30 | Elekta Ab | Control of breathing during MRI-based procedures |
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| DE102014221564A1 (en) * | 2014-10-23 | 2016-04-28 | Siemens Aktiengesellschaft | Improved measurement sequence for determining a magnetic resonance image |
| US11166666B2 (en) * | 2015-10-09 | 2021-11-09 | Koninklijke Philips N.V. | Enhanced acute care management combining imaging and physiological monitoring |
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| CN111243048B (en) * | 2018-11-28 | 2024-01-30 | 西门子(深圳)磁共振有限公司 | Image reconstruction method, device and system in magnetic resonance imaging and storage medium |
| KR20240099851A (en) * | 2022-12-22 | 2024-07-01 | 성균관대학교산학협력단 | Perfusion mri method and system |
| CN116628457B (en) * | 2023-07-26 | 2023-09-29 | 武汉华康世纪医疗股份有限公司 | Harmful gas detection method and device in operation of magnetic resonance equipment |
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| CN111983536A (en) * | 2014-09-05 | 2020-11-24 | 海珀菲纳研究股份有限公司 | Automatic configuration of low-field magnetic resonance imaging system |
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| CN107423538A (en) * | 2016-02-16 | 2017-12-01 | 西门子保健有限责任公司 | Medical examination system |
| CN108377641A (en) * | 2016-11-08 | 2018-08-07 | 中国科学院深圳先进技术研究院 | Magnetic resonance vascular wall imaging method and equipment |
| CN108377641B (en) * | 2016-11-08 | 2020-07-03 | 中国科学院深圳先进技术研究院 | Magnetic resonance blood vessel wall imaging method and equipment |
Also Published As
| Publication number | Publication date |
|---|---|
| JP5960140B2 (en) | 2016-08-02 |
| EP2612159B1 (en) | 2020-03-11 |
| JP2013540461A (en) | 2013-11-07 |
| EP2612159B8 (en) | 2020-04-22 |
| EP2423699A1 (en) | 2012-02-29 |
| CN103080763B (en) | 2016-06-29 |
| US20130225978A1 (en) | 2013-08-29 |
| EP2612159A1 (en) | 2013-07-10 |
| WO2012028997A1 (en) | 2012-03-08 |
| BR112013004380A2 (en) | 2020-08-25 |
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