CN103079609A - A percutaneous medication device and a needle formation used for the device - Google Patents
A percutaneous medication device and a needle formation used for the device Download PDFInfo
- Publication number
- CN103079609A CN103079609A CN2011800408335A CN201180040833A CN103079609A CN 103079609 A CN103079609 A CN 103079609A CN 2011800408335 A CN2011800408335 A CN 2011800408335A CN 201180040833 A CN201180040833 A CN 201180040833A CN 103079609 A CN103079609 A CN 103079609A
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- needle
- configuration
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- Infusion, Injection, And Reservoir Apparatuses (AREA)
Abstract
A percutaneous medication device, comprising a syringe 6 to be filled with medical liquid and a needle formation 1 attached to a leading-end of the syringe 6 is provided. The needle formation 1 comprises a needle formation body 10, from the surface of which a needle 11 projects and a cover portion 24 covers a leading-end of the needle formation body 10. The needle 11 is inserted into a through-hole 16 formed at the leading-end of the needle formation body 10 and fixed by a fixation member 18. The needle formation body 10 is mated to the cover portion 24, a space 30 is formed between an inner surface of the cover portion 24 and the leading-end of the needle formation body 10, and the needle 11 projects from the leading-end surface of the cover portion 24 through a needle insertion hole 32 formed at the leading-end of the cover portion 24.
Description
Technical field
The needle like configuration that the present invention relates to a kind of transdermal delivery device for the applied dermally medicinal liquid and be used for described transdermal delivery device.
Background technology
Usually, syringe be used for using can not oral administration medicinal liquid or medicine (below, be called medicinal liquid).Yet, in utilizing the method for syringe, large and be attended by pain to the stress level of health.Although, used the method for percutaneous dosing of the medicine of paster, the method needs the long period to express drug effect, and available medicine is limited.
In order to address these problems, Japanese Laid-Open Patent 2005-87521 (patent documentation 1), Japanese national phase PCT publication 2010-508058 (patent documentation 2) and Japanese Laid-Open Patent 2007-54194 (patent documentation 3) have proposed a kind of transdermal delivery device, and this transdermal delivery device utilizes the pin of minor diameter to be reduced in when injecting because the pain of the puncture of pin.
In these transdermal delivery devices, by binding agent and analog locking pin thereof, so that pin stretches out with preliminary dimension from the front-end surface of device.Yet, shown in Figure 1 such as patent documentation 3, because the composition that has hardened of binding agent is retained on the front-end surface of device, the size of the hardener of binding agent affects the size that pin stretches out from the surface of the hardener of binding agent.For this reason, the defective of existence is: if the use amount of binding agent changes, the size of stretching out neither be constant.
[reference listing]
[patent documentation]
PTL1: Japanese Laid-Open Patent 2005-87521
PTL2: Japanese national phase PCT publication 2010-508058
PTL3: Japanese Laid-Open Patent 2007-54194
Summary of the invention
Technical problem
Carried out the present invention for addressing the above problem; The object of the present invention is to provide a kind of transdermal delivery device and be used for the pin of this device, described transdermal delivery device can stabilization needle from the size of stretching out of body surfaces.
Solution
In order to address the above problem, the present invention characterizes by following term.
A kind of transdermal delivery device comprises: the needle like configuration (needle formation) that is filled with the syringe of medicinal liquid and is attached to described syringe front end, wherein:
Described needle like configuration comprises needle like configuration main body and cover part, and pin stretches out from the front-end surface of described needle like configuration main body, and described cover part covers the front end of described needle like configuration main body;
Described pin inserts the through hole of the front end that is formed on described needle like configuration main body; And described pin is fixed to described needle like configuration main body by fixed part;
Described needle like configuration main body and described cover part are complementary, and are formed with the space between the front-end surface of the inner surface of described cover part and described needle like configuration main body, and
Described pin stretches out from the front-end surface of described cover part by the cushion hand-hole that is formed on described cover part front end.
According to transdermal delivery device of the present invention, wherein, described cover part has: the elastic component that contacts the outer surface of described needle like configuration main body; Be formed on the mate on the outer surface of described needle like configuration main body; And on described elastic component can with the engaged part of described mate engagement.
According to transdermal delivery device of the present invention, wherein, described fixed component is binding agent, and is furnished with the composition that has hardened in described space.
According to transdermal delivery device of the present invention, further comprise: needle stand, in described needle stand, and described needle like configuration is placed in the needle stand with aseptic condition by the sealing member that can remove that is arranged in the described needle stand wherein said needle like configuration with the state arrangement that can not rotate.
According to transdermal delivery device of the present invention, wherein, described needle like configuration can be attached to the front end of described syringe by road strategic point (Lure) latch-up structure.
According to transdermal delivery device of the present invention, wherein, inner surface in described cover part is formed with the scalariform part, and the front-end surface of described needle like configuration main body and described scalariform part adjacency are to form described space between the front-end surface of the inner surface of described cover part and described needle like configuration main body.
A kind of needle like configuration that is attached to the front end of syringe, wherein:
Described needle like configuration comprises needle like configuration main body and cover part, and pin stretches out from the front-end surface of described needle like configuration main body, and described cover part covers the front end of described needle like configuration main body;
Described pin inserts the through hole of the front end that is formed on described needle like configuration main body, and described pin is fixed to described needle like configuration main body by fixed part;
Described needle like configuration main body and described cover part are complementary, and are formed with the space between the front-end surface of the inner surface of described cover part and described needle like configuration main body, and
Described pin stretches out from the front-end surface of described cover part by the cushion hand-hole that is formed on described cover part front end.
According to needle like configuration of the present invention, wherein, described fixed component is binding agent, and the composition that has hardened of described binding agent is arranged in the described space.
According to needle like configuration of the present invention, wherein, inner surface in described cover part is formed with the scalariform part, and the front-end surface of described needle like configuration main body and described scalariform part adjacency are to form described space between the front-end surface of the inner surface of described cover part and described needle like configuration main body.
Beneficial effect
Needle like configuration comprises needle like configuration main body and cover part, pin stretches out from the front-end surface of described needle like configuration main body, described cover part covers the front end of described needle like configuration main body, described pin inserts the through hole of the front end that is formed on described needle like configuration main body, and described pin is fixed to described needle like configuration main body by fixed part; Described needle like configuration main body and described cover part are complementary, between the front-end surface of the inner surface of described cover part and described needle like configuration main body, be formed with the space, and described pin stretches out from the front-end surface of described cover part by the cushion hand-hole that is formed on described cover part front end.Therefore, be used for the fixed component that described pin is fixed to described needle like configuration main body is arranged in the described space between the front-end surface of the inner surface that is formed on described cover part and described needle like configuration main body.For this reason, the variation of the application quantity of described fixed component (the size of hardener) does not affect described pin from the size of stretching out on the surface of described cover part.
Described needle like configuration comprises needle like configuration main body and the cover part that covers the front end of described needle like configuration main body; Described cover part has: contact the elastic component of the outer surface of described needle like configuration main body, be formed on the mate on the outer surface of described needle like configuration main body, and on described elastic component can with the engaged part of described mate engagement; Thereby described needle like configuration can easily dispose by simply described needle like configuration and described cover part being complementary.
Described needle like configuration is disposed in the needle stand, described needle like configuration is isolated with aseptic condition by the containment member that can remove, in described needle stand, and described needle like configuration is attached to the front end of described syringe to described needle like configuration by road strategic point latch-up structure with the state arrangement that can not rotate; Therefore, described needle like configuration is placed in the described needle stand with aseptic condition, and the front end that in addition described needle like configuration is attached to described syringe by described road strategic point latch-up structure to be to rotate described needle like configuration, and described needle like configuration can be taken out from described needle stand.
As mentioned above, can the load thinner pin of liquid injection device of the present invention is to ease the pain in skin puncture, and in addition, the size that pin stretches out from the surface of pin main body can be constant.
Description of drawings
Fig. 1 is the sectional view of needle like configuration that is attached to the front end of syringe;
Fig. 2 is syringe and makes needle like configuration be arranged in the sectional view of the needle like configuration in the needle stand;
Fig. 3 is the needle like configuration main body of formation needle like configuration and the decomposition section of cover part;
Fig. 4 is the amplification sectional view of the major part of needle like configuration;
Fig. 5 is the sectional view that is placed on the needle like configuration in the needle stand;
Fig. 6 is the sectional view from front end of the needle like configuration shown in the Fig. 5 that is placed in the needle stand;
Fig. 7 is the perspective view that is arranged in the needle like configuration in the described needle stand.
The specific embodiment
Below, explain in detail embodiments of the present invention with reference to accompanying drawing.
As shown in Figures 1 to 4, transdermal delivery device 5 of the present invention comprises: the syringe 6 that will be filled by medicinal liquid is attached to the needle like configuration 1 of the front end of syringe 6 and the needle stand 40 that holds needle like configuration 1 with aseptic condition.
Needle like configuration 1 comprises needle like configuration main body 10 and cover part 24, and in needle like configuration main body 10, pin 11 stretches out from the front-end surface of needle like configuration main body 10, and cover part 24 covers the front end of needle like configuration main body 10.Needle like configuration main body 10 forms cylindrical shape usually, and an end of needle like configuration main body 10 is opened, and is formed with the wheel rim 12 that can mesh strategic point lock part 20, road in the bottom of needle like configuration main body 10.At the front end place of needle like configuration main body 10, be formed with through hole 16 to pass pin 11.As shown in Figure 7, in the present embodiment, be formed with three through holes 16; Yet, can be formed with two through holes or equal or more than four through holes.
As shown in Figure 4, on the surface of the front end of needle like configuration main body 10, be formed with mortar shape depression 15 in the edge of through hole 16, and binding agent 18 can 15 be applied to through hole 16 by caving in.
On the outer surface of needle like configuration main body 10, semi-circular projection is stretched out as mate 17.
In elastic component 26, engaging hole 27 forms engaged part in the position corresponding with the mate (projection) 17 on the outer surface that is formed on needle like configuration main body 10.
At the inner surface of head 25, be formed with scalariform part 28.When needle like configuration main body 10 was inserted into the inside of cover part 24 and coupling when upper, the front-end surface of needle like configuration main body 10 leans on scalariform part 28 to form space 30 between the front-end surface of the inner surface of the front end of cover part 24 and needle like configuration main body 10.
At this moment, the projection 17 of needle like configuration main body 10 fastens engaging hole 27 engagements on ground and the elastic component 26 that is formed on cover part 24.
Therefore, when needle like configuration 10 during with cover part 24 coupling, the cushion hand-hole 32 of the front end of pin 11 by being formed on lid 24 stretches out (Fig. 1) from the front-end surface of cover part 24.
As shown in Figure 3, cushion hand-hole 32 can form cone shape, so that the internal diameter increase, more near needle like configuration main body 10.By forming the taper part 32a with taperer at the face of opening of cushion hand-hole 32, the pin 11 that stretches out from the front end of needle like configuration main body 10 can easily be inserted into the patchhole 32, and the resin of cover part 24 can not adhere to the tip of pin.
The example that is used for the constituent material of pin 11 is, but is not limited to, such as metal material and the analog thereof of rustless steel, aluminum or aluminum alloy, titanium or titanium alloy.The size of stretching out of the pin 11 that preferably, stretches out from the surface of needle like configuration 1 is equal to or less than 3mm; More preferably, in the scope of 0.5mm to 2.0mm, and, further preferably, in the scope of 0.5mm to 1.5mm.Preferably, the maximum outside diameter of pin 11 in the scope of 0.1mm to 0.6mm, and further preferably, in the scope of 0.2mm to 0.6mm.The tip of pin 11 is the tubular element shape of cutting sth. askew.
Can come manufacturing needles columnar structure 1 as the material injection molded by using the thermoplastic resin such as Merlon, polypropylene, ABS resin, polystyrene and analog etc.
To shown in Figure 7, above-mentioned needle stand 40 comprises: usually form the rack body 41 of cylindrical shape, an end of rack body 41 is opened such as Fig. 5; And the wheel rim of opening end face 42 that is formed on rack body 41.Depression 43 with triangular cross section is formed on the inner surface of front end face of rack body 41.This depression 43 so forms, so that 43 the shape of caving in is consistent with the shape of the front end of the cover part 24 of needle like configuration 1.Namely, the external shape of the head part 25 of cover part 24 is generally triangle, and when the head part 25 of cover part 24 was inserted the depression 43 of rack body 41, needle like configuration 1 can not be rotated with respect to rack body 41.
The containment member of opening end 44 that can closed rack body 41 is attached to the wheel rim 42 of rack body 41.Opening of containment member 44 sealed support main bodys 41 held so that the needle like configuration 1 that is placed in the needle stand 40 is isolated with aseptic condition.Utilize finger or analog can open end by removing containment member 44 from wheel rim 42.
Next, the operational approach of transdermal delivery device 5 of the present invention will be explained.
Because needle like configuration 1 is stored in the needle stand 40 with aseptic condition, the containment member 44 of needle stand 40 removes with outside exposed needle columnar structure 1 from wheel rim.
Next, clamp needle stand 40 by finger or analog, the wheel rim 12 of road strategic point lock part 20 and needle like configuration 1 that is formed on the front end of syringe 6 meshes to rotate syringe 6.Because needle like configuration 1 can not be rotated with respect to needle stand 40, wheel rim 12 engagements of the strategic point lock part 20, road of syringe 6 and needle like configuration 1.Under this situation, when syringe 6 was extracted from needle stand 40, needle like configuration 1 was attached to the front end (Fig. 1) of syringe 6.
Then, according to conventional method, by the piston 8 of extruding syringe 6, the medicinal liquid in the syringe 6 enters the space segment 36 of needle like configuration 1; In addition, release medicinal liquid by the pin 11 of needle like configuration 1 from the tip of pin 11.
Usually, the medicinal liquid for liquid injection device 1 is solution, gel or the suspension that contains medicament.Except those are not suitable for the medicament of percutaneous dosing, available medicament there is no restriction.
It below is the example of main medicament: hyaluronic acid, collagen protein, Botox, antibacterial, antiviral, vaccine, antitumor, immunosuppressant, steroid, antiinflammatory, antirheumatic, antiarthritic, antihistaminic, Claritin, diabetes medicament, hormone agents, bone/calcium metabolism medicine, vitamin, blood preparaton (hematic preparation), hematonic, antithrombotic agent, lipid lowerers, anti-arrhythmic, vasodilator, prostaglandin, calcium antagonist, ACE inhibitor, beta-blocker, depressor, diuretic, xanthine derivative, the beta receptor agonist, antiasthmatics, cough medicine, expectorant, anticholinergic agents, astringent, the invigorating the stomach and promoting digestion agent, antiulcerative, cathartic, the Gelineau's syndrome medicine, tranquilizer, antipyretic, coldrex, antuepileptic, neuroleptic agent, antidepressants, antianxiety drugs, analeptic, parasympathomimetic agent, the sympathetic nerve medicine, Bendectin, analeptic, antiparkinsonism drug, muscle relaxant, spasmolytic, anesthetics, pruritus, antimigraine, diagnostic reagent, oligonucleotide, genomic medicine and analog thereof.
Here, preferably, protein, peptide, polysaccharide, oligonucleotide, DNA and analog that medicine weakens for do not show effect or effect in oral administration, particularly, the medicine of high molecular, for example insulin, growth hormone, interferon, calcitonin and analog thereof.
The shape of cross section of needle like configuration 1 also needs not be cylindric, but may be square or elliptical shape.In addition, the external shape that is formed on the head part 25 of the shape of the depression 43 in the needle stand 40 and cover part 24 also is not limited to triangle; Alternately, this shape can be square, and is oval etc.Fang Shuanke is formed on the inner surface of wall of needle stand 40 to be meshed with protuberance on the outer surface that is formed on needle like configuration 1.Protuberance can be formed on the outer surface of needle like configuration main body 10.Taperer can be arranged on the depression 43 of needle stand 40 with such configuration needle stand: so that the front end of needle like configuration 1 easily inserts in the depression 43.
In this embodiment, in the position of the front-end surface of needle like configuration 1, three pins 11 are formed on the equidistant position of distance center, and have each other the isolation angles of 120 degree.Yet present embodiment does not limit position and the number of pin 11.
Reference numeral
1 needle like configuration
5 transdermal delivery devices
6 syringes
10 needle like configuration main bodys
11 pins
18 fixed components
24 cover parts
30 spaces
40 needle stands
Claims (9)
1. transdermal delivery device comprises: the syringe that will be filled by medicinal liquid; And the needle like configuration that is attached to described syringe front end, wherein:
Described needle like configuration comprises needle like configuration main body and cover part, and pin stretches out from the front-end surface of described needle like configuration main body, and described cover part covers the front end of described needle like configuration main body;
Described pin inserts the through hole of the front end that is formed on described needle like configuration main body, and described pin is fixed to described needle like configuration main body by fixed part;
Described needle like configuration main body and described cover part are complementary, and are formed with the space between the front-end surface of the inner surface of described cover part and described needle like configuration main body, and
Described pin stretches out from the front-end surface of described cover part by the cushion hand-hole that is formed on described cover part front end.
2. transdermal delivery device according to claim 1, wherein, described cover part comprises: the elastic component that contacts the outer surface of described needle like configuration main body; Be formed on the mate on the outer surface of described needle like configuration main body; And be formed on the described elastic component can with the engaged part of described mate engagement.
3. transdermal delivery device according to claim 1, wherein, described fixed component is binding agent, and is furnished with the composition that has hardened in described space.
4. transdermal delivery device according to claim 1, further comprise: needle stand, in described needle stand, and described needle like configuration is placed in the needle stand with aseptic condition by the sealing member that can remove that is arranged in the described needle stand wherein said needle like configuration with the state arrangement that can not rotate.
5. transdermal delivery device according to claim 1, wherein, described needle like configuration can be attached to the front end of described syringe by road strategic point latch-up structure.
6. transdermal delivery device according to claim 1, wherein, inner surface in described cover part is formed with the scalariform part, and the front-end surface of described needle like configuration main body and described scalariform part adjacency are to form described space between the front-end surface of the inner surface of described cover part and described needle like configuration main body.
7. needle like configuration that is attached to the front end of syringe, wherein,
Described needle like configuration comprises needle like configuration main body and cover part, and pin stretches out from the front-end surface of described needle like configuration main body, and described cover part covers the front end of described needle like configuration main body;
Described pin inserts the through hole of the front end that is formed on described needle like configuration main body, and described pin is fixed to described needle like configuration main body by fixed part;
Described needle like configuration main body and described cover part are complementary, and are formed with the space between the front-end surface of the inner surface of described cover part and described needle like configuration main body; And
Described pin stretches out from the front-end surface of described cover part by the cushion hand-hole that is formed on described cover part front end.
8. needle like configuration according to claim 7, wherein, described fixed component is binding agent, and the composition that has hardened of described binding agent is arranged in the described space.
9. needle like configuration according to claim 7, wherein, inner surface in described cover part is formed with the scalariform part, and the front-end surface of described needle like configuration main body and described scalariform part adjacency are to form described space between the front-end surface of the inner surface of described cover part and described needle like configuration main body.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2010186653 | 2010-08-23 | ||
| JP2010-186653 | 2010-08-23 | ||
| PCT/JP2011/004640 WO2012026100A1 (en) | 2010-08-23 | 2011-08-19 | A percutaneous medication device and a needle formation used for the device |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103079609A true CN103079609A (en) | 2013-05-01 |
| CN103079609B CN103079609B (en) | 2015-06-24 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201180040833.5A Expired - Fee Related CN103079609B (en) | 2010-08-23 | 2011-08-19 | A percutaneous medication device and a needle formation used for the device |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US9808583B2 (en) |
| EP (1) | EP2608824A4 (en) |
| JP (1) | JP5918752B2 (en) |
| KR (1) | KR101502893B1 (en) |
| CN (1) | CN103079609B (en) |
| WO (1) | WO2012026100A1 (en) |
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| CN106061543A (en) * | 2014-03-20 | 2016-10-26 | 株式会社爱茉莉太平洋 | Liquid injection device |
| CN109862863A (en) * | 2016-11-21 | 2019-06-07 | 泰尔茂株式会社 | Chemical Filling Unit, Chemical Filling Assembly, and Filling Adapter |
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| USD711531S1 (en) * | 2011-09-27 | 2014-08-19 | Nanbu Plastics Co., Ltd. | Injection needle |
| JP6037722B2 (en) * | 2012-08-27 | 2016-12-07 | 南部化成株式会社 | Needle |
| US20140350518A1 (en) | 2013-05-23 | 2014-11-27 | Allergan, Inc. | Syringe extrusion accessory |
| US10029048B2 (en) | 2014-05-13 | 2018-07-24 | Allergan, Inc. | High force injection devices |
| US10226585B2 (en) | 2014-10-01 | 2019-03-12 | Allergan, Inc. | Devices for injection and dosing |
| AU2016229013B2 (en) | 2015-03-10 | 2020-05-21 | Allergan Sales, Llc | Multiple needle injector |
| AU2017246114B2 (en) | 2016-04-08 | 2022-03-17 | Allergan, Inc. | Aspiration and injection device |
| JP3207783U (en) | 2016-09-20 | 2016-12-01 | 南部化成株式会社 | Needle |
| USD867582S1 (en) | 2017-03-24 | 2019-11-19 | Allergan, Inc. | Syringe device |
| JP7001529B2 (en) * | 2018-04-13 | 2022-01-19 | デンカ株式会社 | Jig and manufacturing method |
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Also Published As
| Publication number | Publication date |
|---|---|
| US20130184648A1 (en) | 2013-07-18 |
| EP2608824A1 (en) | 2013-07-03 |
| KR20130080838A (en) | 2013-07-15 |
| JP2013539990A (en) | 2013-10-31 |
| JP5918752B2 (en) | 2016-05-18 |
| CN103079609B (en) | 2015-06-24 |
| HK1180256A1 (en) | 2013-10-18 |
| EP2608824A4 (en) | 2017-11-08 |
| US9808583B2 (en) | 2017-11-07 |
| WO2012026100A1 (en) | 2012-03-01 |
| KR101502893B1 (en) | 2015-03-16 |
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