CN103055257A - Traditional Chinese medicine for treating chronic gastritis and preparation method thereof - Google Patents
Traditional Chinese medicine for treating chronic gastritis and preparation method thereof Download PDFInfo
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- CN103055257A CN103055257A CN201210573526XA CN201210573526A CN103055257A CN 103055257 A CN103055257 A CN 103055257A CN 201210573526X A CN201210573526X A CN 201210573526XA CN 201210573526 A CN201210573526 A CN 201210573526A CN 103055257 A CN103055257 A CN 103055257A
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Abstract
The invention aims to provide a traditional Chinese medicine for treating chronic gastritis and a preparation method thereof. The traditional Chinese medicine comprises coptis, root of large-flowered skullcap, dried orange peel, prepared pinellia tuber, Poria cocos, bighead atractylodes rhizome, coix seed, honey-fried licorice root, curcuma rhizome, hairyvein agrimony, madder, cuttlebone and Zhejiang fritillaria bulb. The traditional Chinese medicine provided by the invention mainly clears heat, drains dampness, harmonizes the stomach and relieves pains, and comprehensive adjustment of all the internal organs is carried out; deficiency and excess are clearly differentiated, and tonifying, clearing and surrendering are organically combined together, which is a combined therapy for comprehensive adjustment of a human body. The traditional Chinese medicine for treating chronic gastritis has a good therapeutic effect on chronic gastritis and is particularly applicable to treatment of damp-heat type chronic gastritis; no adverse reaction is spotted in treatment process, and the traditional Chinese medicine is safe and reliable.
Description
Technical field
The present invention relates to field of medicaments, be specifically related to a kind of Chinese medicine for the treatment of chronic gastritis and preparation method thereof.
Background technology
Chronic gastritis (chronic gestritis) means chronic inflammatory disease or the atrophic lesion of the gastric mucosa that different pathogeny causes, after its essence is that gastric epithelial suffers repeatedly to damage, because the special regeneration capacity of mucosa, so that mucosa is reconstructed, and finally cause the atrophy of irreversible intrinsic gastric gland body, even disappear.Primary disease is very common, accounts for to accept gastroscopy patient's 80～90%, and the male increases with the age growth sickness rate gradually more than the women.The pathological change of chronic gastritis is confined to mucous layer substantially, therefore strictly says to be referred to as " chronic gastric mucositis " or " gastric mucosa is sick ".According to the record of Schindler, " chronic gastritis " is that Stahl at first proposed in 1728, constantly reports to some extent thereafter.But there is difference all the time in this diagnosis.Especially after Cruveilhier in 1830 finds gastric ulcer, for the patient that epigastrium pain is arranged, often be diagnosed as Peptic Ulcers or stomach neurosis and do not diagnose gastritis.
The main clinical manifestation of chronic gastritis is Upper abdominal pain, feeling of repletion, heating installation, feel sick, acid regurgitation etc.The cause of disease of chronic gastritis is many with being invaded by exogenous pathogen, temperament and interest internal injury, eating and drinking without temperance and have a delicate constitution etc. relevant.Along with the raising of people's living standard, the quickening of rhythm of life and the increase of operating pressure.The sickness rate of chronic gastritis is year by year ascendant trend.Modern medicine understanding, chronic gastritis mainly infects caused gastric mucosa chronic inflammatory disease by stomach Helicobacter pylori (H. pylori), most take gastric antrum as main full gastritis, gastric mucosa layer is take lymphocyte and plasmocyte infiltrating as main, and the some patients were later stage can show as the body of gland atrophy and change and give birth to.China H. pylori infection population estimates 50% ~ 70%, and infection rate has with the age and increase the trend that raises, estimates that accordingly China is grown up the chronic gastritis prevalence at least more than 50%.
Damp-heat syndrome is the common disease of tcm clinical practice, along with the change of current spectrum of disease, and the variation of people's body constitution and dietary structure, damp-heat syndrome is more and more common.To the clinical studies show of damp-heat syndrome in the spleen-stomach disease excess syndrome, syndrome of dampness-heat of spleen and stomach accounts for the first place in the chronic gastritis.The key of chronic gastritis will " be prevented and treated ", Patients with Chronic Gastritis is generally being deposited in several years more than ten years even Relapse rate outbreak decades, even progress causes peptic ulcer, gastric cancer, bad during the symptom fashion, the maintenance drug therapy curative effect is limited, even hospitalization, and effect is undesirable, can not get radical cure, its reason is not fundamentally executed to control.
Summary of the invention
The purpose of this invention is to provide a kind of Chinese medicine for the treatment of chronic gastritis and preparation method thereof, the treatment by Chinese herbs chronic gastritis for the treatment of chronic gastritis provided by the present invention is respond well, especially be fit to the chronic gastritis for the treatment of damp-heat type, and in therapeutic process, do not find untoward reaction, safe and reliable.
The Chinese medicine for the treatment of chronic gastritis of the present invention is to be prepared from by the raw material that comprises following weight portion:
Rhizoma Coptidis 3～20 Radix Scutellariaes 5～40 Pericarpium Citri Reticulataes 5～40 Rhizoma Pinelliae Preparatum 5～40
Poria 10～50 Rhizoma Atractylodis Macrocephalaes 10～50 Semen Coiciss 20～60 Radix Glycyrrhizae Preparata 5～40
Rhizoma Curcumae 10～50 Herba Agrimoniaes 10～50 Radix Rubiaes 2～15 Endoconcha Sepiaes 20～60
Bulbus Fritillariae Thunbergii 5～40.
The Chinese medicine for the treatment of chronic gastritis of the present invention, its preferred version are to be prepared from by the raw material that comprises following weight portion:
Rhizoma Coptidis 5～15 Radix Scutellariaes 10～30 Pericarpium Citri Reticulataes 10～30 Rhizoma Pinelliae Preparatum 10～30
Poria 20～40 Rhizoma Atractylodis Macrocephalaes 20～40 Semen Coiciss 30～50 Radix Glycyrrhizae Preparata 10～30
Rhizoma Curcumae 20～40 Herba Agrimoniaes 20～40 Radix Rubiaes 3～9 Endoconcha Sepiaes 30～50
Bulbus Fritillariae Thunbergii 10～30.
The Chinese medicine for the treatment of chronic gastritis of the present invention, its further preferred version is to be prepared from by the raw material that comprises following weight portion:
Rhizoma Coptidis 8 Radix Scutellariaes 20 Pericarpium Citri Reticulataes 20 Rhizoma Pinelliae Preparatum 24
Poria 30 Rhizoma Atractylodis Macrocephalaes 30 Semen Coiciss 40 Radix Glycyrrhizae Preparata 20
Rhizoma Curcumae 30 Herba Agrimoniaes 30 Radix Rubiaes 6 Endoconcha Sepiaes 40
Bulbus Fritillariae Thunbergii 20.
The Chinese medicine for the treatment of chronic gastritis of the present invention, its active component is prepared from by the following method:
Get whole 13 flavor medical materials, extracting in water twice adds the water that is equivalent to 6～12 times of medical material gross weights for the first time, extracts 1～3 hour, adds for the second time the water that is equivalent to 6～12 times of medical material gross weights, extracts 1～3 hour; Merge extractive liquid,, relative density is 1.20～1.26 extractum when being concentrated into 80 ℃, adding ethanol to the concentration of volume percent that contains the alcohol amount is 50%～60%, stir even, left standstill 12～24 hours, filter, relative density was 1.22～1.30 extractum when filtrate was concentrated into 80 ℃, namely got described active component.
The Chinese medicine for the treatment of chronic gastritis of the present invention, its active component are to be prepared from by following method for optimizing:
Get whole 13 flavor medical materials, extracting in water twice adds the water that is equivalent to 8～10 times of medical material gross weights for the first time, extracts 2 hours, adds for the second time the water that is equivalent to 8～10 times of medical material gross weights, extracts 2 hours; Merge extractive liquid,, relative density is 1.23 extractum when being concentrated into 80 ℃, adding ethanol to the concentration of volume percent that contains the alcohol amount is 56%, stir and spare, left standstill 12～24 hours, filter, relative density was 1.26 extractum when filtrate was concentrated into 80 ℃, namely got described active component.
The Chinese medicine for the treatment of chronic gastritis of the present invention, its capsule is prepared from by the following method: get whole 13 flavor medical materials, clean, drying and sterilizing is pulverized, and crosses 80 orders～l20 mesh sieve, incapsulates, and get final product.
The Chinese medicine for the treatment of chronic gastritis of the present invention can cooperate with pharmaceutically acceptable carrier, makes various common dosage forms.
The Chinese medicine details is as follows among the present invention:
Rhizoma Coptidis
This product is the dry rhizome of ranunculaceae plant Rhizoma Coptidis Coplis chinensis Franch., Coptis deltoidea C.Y.Cheng et Hsiao Coptis deltoidea C.Y.Cheng et Hsiao or Coptis Teeta Wall Coptisteeta Wall..More than three kinds practise to claim respectively " flavor connects ", " refined company ", " Coptis Teeta Wall ".Dig autumn, removes fibrous root and silt, and drying is hit residual fibrous root.Bitter in the mouth, cold in nature.GUIXIN, spleen, stomach, liver, gallbladder, large intestine channel.The function heat clearing and damp drying, eliminating fire and detoxication.Be used for damp and hot feeling of fullness, the vomiting acid regurgitation, dysentery, jaundice, unconsciousness due to high fever, hyperactivity of heart-fire, dysphoria and insomnia, palpitation and uneasiness, heat in blood is told nosebleed, conjunctival congestion, toothache is quenched one's thirst, and carbuncle is treated skin ulcer; External treatment eczema, eczema, auditory meatus is suppurated.The kind clear part of the body cavity above the diaphragm housing the heart and lungs of Rhizoma Coptidis (processed with wine) is burning hot.Be used for conjunctival congestion, aphtha.Prepared RHIZOMA COPTIDIS with rhizoma zingiberis recens juice clearing stomach stomach function regulating preventing or arresting vomiting.Be used for cold and heat and tie mutually, damp and hot middle resistance, feeling of fullness vomiting.Cornel Rhizoma Coptidis soothing liver-QI stomach function regulating preventing or arresting vomiting.Be used for incoordination between the liver and stomach, the vomiting acid regurgitation.
Radix Scutellariae
This product is the dry root of labiate Radix Scutellariae Scutellaria baicalensis Georgi.Spring, Qiu Erji excavate, and remove fibrous root and silt, hit rough bark after the solarization, dry.Bitter in the mouth, cold in nature.Return lung, gallbladder, spleen, large intestine, small intestine meridian.The function heat clearing and damp drying, eliminating fire and detoxication, hemostasis, antiabortive.Be used for hygropyrexia, fever disease in summer vomiting and nausea uncomfortable in chest, damp and hot feeling of fullness, dysentery, jaundice, the cough due to lung-heat, high hot excessive thirst, heat in blood is told nosebleed, carbuncle sore tumefacting virus, frequent fetal movement.
Pericarpium Citri Reticulatae
This product is the dry mature skin of rutaceae orange Citrus reticulata Blanco and variety thereof.Medical material is divided into " Pericarpium Citri Reticulatae " and " Pericarpium citri reticuatae chachiensis ".Pluck mature fruit, strip peel, dry or cold drying.Bitter in the mouth, suffering, warm in nature.Return lung, spleen channel.The function regulating qi-flowing for strengthening spleen, drying dampness to eliminate phlegm.Be used for distension and fullness in the abdomen, lack of appetite and vomiting, cough with copious phlegm.Acrid in the mouth, warm in nature.Return spleen, stomach, lung meridian.The function drying dampness to eliminate phlegm.Be used for the abundant expectoration cough with asthma, phlegm retention vertigo and palpitation, dizziness due to wind-phlegm, syncope due to accumulation of phlegm headache.
Rhizoma Pinelliae Preparatum
This product is for being the tuber of the aroid Rhizoma Pinelliae (Pinellia ternata (Thunb) Breit.).The Preparation process product that drying forms after the soaking with the Radix Glycyrrhizae lime liquor of Rhizoma Pinelliae.Acrid in the mouth, warm in nature.Return spleen, stomach, lung meridian.The function drying dampness to eliminate phlegm.Be used for the abundant expectoration cough with asthma, phlegm retention vertigo and palpitation, dizziness due to wind-phlegm, syncope due to accumulation of phlegm headache.
Poria
This product is On Polyporaceae Poria Poria cocos(Schw.) dry sclerotia of Wolf.More than excavating the 7-9 month, remove silt after digging out, after bank up " diaphoresis ", spread out and dry in the air to dry tack free, again " diaphoresis " after extremely now wrinkle, large of internal moisture are scattered and disappeared for several times repeatedly, dries in the shade, and is called " Poria is individual "; Or bright Poria pressed the different parts cutting, cloudy in, be called " Cortex Sclerotii Poriae " and reach " Poria piece ".Sweet in the mouth, light, property is flat.GUIXIN, lung, spleen, kidney channel.The function promoting diuresis to eliminate damp pathogen, the spleen invigorating mind calming.Be used for the edema oliguria. the phlegm retention vertigo and palpitation, insufficiency of the spleen lack of appetite, have loose bowels in the loose stool, irritability, palpitation with fear insomnia.
The Rhizoma Atractylodis Macrocephalae
This product is the dry rhizome of feverfew Rhizoma Atractylodis Macrocephalae Atractylodes macrocephala Koidz..Winter the bottom leaf withered and yellow, excavate when upper leaf becomes fragile, remove silt, dry or dry, remove again fibrous root.Bitter in the mouth, sweet, warm in nature.Return spleen, stomach warp.The function invigorating the spleen and benefiting QI, the dampness diuretic, hidroschesis, antiabortive.Be used for insufficiency of the spleen lack of appetite, abdominal distention is had loose bowels, phlegm retention vertigo and palpitation, edema, spontaneous perspiration, frequent fetal movement.
Semen Coicis
This product is the dry mature kernal of grass Semen Coicis Coix lacrymajobi L.var.mayuen. (Roman.) Stapf.Tap plant during fruit maturation autumn, dries, and lays fruit, dries again, except decapsidate, yellowish-brown kind skin and impurity, collects kernel.Sweet in the mouth, light, cool in nature.Return spleen, stomach, lung meridian.The function promoting diuresis to eliminate damp pathogen, invigorating the spleen to arrest diarrhea, eliminating impediment, evacuation of pus, detoxicating and resolving stagnation of pathogens.Be used for edema, beriberi, dysuria, diarrhea due to hypofunction of the spleen, arthralgia chiefly caused by damp pathogen contracture, lung abscess, acute appendicitis, wart, cancerous protuberance.
Radix Glycyrrhizae Preparata
This product is the Preparation process product of Radix Glycyrrhizae, and Radix Glycyrrhizae Preparata is the Radix Glycyrrhizae of smoking with honey.Sweet in the mouth, property is flat.GUIXIN, lung, spleen, stomach warp.Function spleen reinforcing stomach function regulating, Yiqi and vein recovery.Be used for weakness of the spleen and stomach, fatigue and weakness, severe palpitation, irregularly intermittent and regularly intermittent pulse.
Rhizoma Curcumae
This product is the dry rhizome of zingiberaceous plant Rhizoma Curcumae Curcuma phaeocaulis Val., Guangxi zedoary Curcuma kwangsuensis S.G.Lee et C.F.Liang or RADIX CURCUMAE Curcuma wenyujin Y.H.Chen et C.Ling.The latter practises title " warm Rhizoma Curcumae ".Winter, stem and leaf was excavated after withered, cleaned, and steamed or boiled to the saturating heart, dry or cold drying after remove fibrous root and impurity.Acrid in the mouth, hardship, warm in nature.Return liver, spleen channel.Function circulation of qi promoting removing blood stasis, the removing food stagnancy pain relieving.Be used for abdominal mass abdominal mass mass in the abdomen, blood stasis amenorrhea, obstruction of qi in the chest and cardialgia, food stagnation distending pain.
Herba Agrimoniae
This product is the dry aerial parts of rosaceous plant Agrimony Agrimonia pilosa Ledeb..Summer, autumn tapped when two seasons, stem and leaf was luxuriant, removed impurity, drying.Bitter in the mouth, puckery, property is flat.GUIXIN, Liver Channel.The function astringing to arrest bleeding, preventing the attack (or recurrence) of malaria, dysentery relieving, detoxifcation, tonify deficiency.Be used for spitting of blood, spit blood, metrostaxis, malaria, dysentery, carbuncle sore tumefacting virus, the pudendal pruritus leukorrhagia takes off the power impairment caused by overstrain.
Radix Rubiae
This product is dry root and the rhizome of Maguireothamnus speciosus Radix Rubiae Rubia cordifolia L..Spring, Qiu Erji excavate, and remove silt, drying.Bitter in the mouth, cold in nature.Return Liver Channel.The function removing heat from blood, blood stasis dispelling, hemostasis is stimulated the menstrual flow.Be used for spitting blood epistaxis, metrorrhagia, traumatic hemorrhage, stasis blocking amenorrhea, arthralgia, tumbling and swelling.
Endoconcha Sepiae
This product is the dry inner shell of Sepiidae animal sepiella maindroni de Rochebrune Sepiella maindronide Rochebrune or golden cuttlefish Sepia esculenta Hoyle.Collect the bone shape inner shell of sepiellae seu sepiae fish, cleaning, drying.Salty in the mouth, puckery, warm in nature.Return spleen, kidney channel.The function astringing to arrest bleeding, relieving leukorrhea by astringents, relieving gastric hyperacidity to alleviate stomachache, removing dampness sore.Be used for hematemesis and epistaxis, metrorrhagia is had blood in stool, emission and spermatorrhea, leucorrhea with red and white discharge, stomachache acid regurgitation; The external treatment bleeding due to trauma, eczema eczema, ulcer being unable to heal.
Bulbus Fritillariae Thunbergii
This product is the dry bulb of liliaceous plant Bulbus Fritillariae Thunbergii FritillariathunbergiiMiq..Excavate when plant is withered early summer, cleans.Size is separated, and large person is except the coring bud, and habit claims " Bulbus Fritillariae Thunbergii "; Little person is the coring bud not, practises claiming " pearl shellfish ".Hit respectively wiping, remove crust, the conch meal of mixing to forge sucks the juice that clashes, drying; Or get bulb, and size is separately cleaned, and except the coring bud, take advantage of fresh-cut and become sheet, cleaning, drying, habit claims " Bulbus Fritillariae Thunbergii sheet ".Bitter in the mouth, cold in nature.Return lung, heart channel.The function clearing heat, eliminating phlegm, relieving cough, the detoxicating and resolving stagnation of pathogens eliminating carbuncle.Be used for the cough due to pathogenic wind-heat, phlegm-fire cough, lung abscess, acute mastitis, scrofula, sore.
Rhizoma Coptidis, Radix Scutellariae purging liver-fire among the present invention, heat clearing and damp drying, and energy anti-inflammation, the eradication rate of raising H.pylori reduces the inflammatory factor effect; Pericarpium Citri Reticulatae, Rhizoma Pinelliae Preparatum, Poria, the Rhizoma Atractylodis Macrocephalae, Semen Coicis have the sending down the abnormal ascending QI dampness removing, and strengthening the spleen to promote digestion can promote gastrointestinal peristalsis, and small-molecule substance has the reparation gastric mucosa, and antioxidation strengthens immunologic function; Rhizoma Curcumae, Herba Agrimoniae, Radix Rubiae energy blood circulation promoting and blood stasis dispelling, nourishing blood to restore normal menstruation, eliminating blood stasis to promote regeneration of blood, effective ingredient can activate gastrointestinal tract pacemaker cell Cajal Interstitial cell comprehensively, make impaired cytothesis regeneration; Endoconcha Sepiae, Bulbus Fritillariae Thunbergii have the effect of gastric acid inhibitory, astringing for hemostasis, contain 5-hydroxy tryptamine and another kind of material, may adsorb blood that toxin and antibacterial are arranged and ooze out mucus, and contained calcium carbonate in the medicine can be made antacid; Radix Glycyrrhizae Preparata energy benefiting vital QI and blood, relieving spasm to stop pain, effective ingredient can promote blood capillary regeneration, and antioxidation makes blood circulation steadily recover self-regulating function in the blood pressure lowering, and to Gastric cancer, tumor has fine inhibitory action.The present invention take clearing away heat-damp and promoting diuresis and stomach and alleviating pain as main, each internal organs is regulated comprehensively, differentiate deficiency and excess, accomplish that invigorating middle warmer has clearly, have in clear and fall, this is the composite treatment of comprehensive balance the body.
Clinical test results such as embodiment 7 and embodiment 8 shows that treatment by Chinese herbs chronic gastritis of the present invention has preferably effect, and effective percentage can reach more than 96%; And execute in the process of controlling clinical, have no toxic and side effects, safe and reliable.
Chinese medicine provided by the invention has overcome the defective of prior art, has outstanding substantive distinguishing features and progressive significantly with respect to prior art.
The specific embodiment
Embodiment 1
Rhizoma Coptidis 30g Radix Scutellariae 50g Pericarpium Citri Reticulatae 50g Rhizoma Pinelliae Preparatum 50g
Poria 100g Rhizoma Atractylodis Macrocephalae 100g Semen Coicis 200g Radix Glycyrrhizae Preparata 50g
Rhizoma Curcumae 100g Herba Agrimoniae 100g Radix Rubiae 20g Endoconcha Sepiae 200g
Bulbus Fritillariae Thunbergii 50g
Get whole 13 flavor medical materials, extracting in water twice, the water that add 6600g the first time extracted 1 hour, added the water of 6600g for the second time, extracted 1 hour; Merge extractive liquid,, relative density is 1.20 extractum when being concentrated into 80 ℃, adding ethanol to the concentration of volume percent that contains the alcohol amount is 50%, stir and spare, left standstill 12 hours, filter, relative density was 1.22 extractum when filtrate was concentrated into 80 ℃, namely got described active component.
Embodiment 2
Rhizoma Coptidis 200g Radix Scutellariae 400g Pericarpium Citri Reticulatae 400g Rhizoma Pinelliae Preparatum 400g
Poria 500g Rhizoma Atractylodis Macrocephalae 500g Semen Coicis 600g Radix Glycyrrhizae Preparata 400g
Rhizoma Curcumae 500g Herba Agrimoniae 500g Radix Rubiae 150g Endoconcha Sepiae 600g
Bulbus Fritillariae Thunbergii 400g
Get whole 13 flavor medical materials, extracting in water twice, the water that add 71400g the first time extracted 3 hours, added the water of 71400g for the second time, extracted 3 hours; Merge extractive liquid,, relative density is 1.26 extractum when being concentrated into 80 ℃, adding ethanol to the concentration of volume percent that contains the alcohol amount is 60%, stir and spare, left standstill 24 hours, filter, relative density was 1.30 extractum when filtrate was concentrated into 80 ℃, namely got described active component.
Active component is mixed with appropriate amount of starch and dextrin, granulate, drying, tabletting namely gets tablet of the present invention.
Embodiment 3
Rhizoma Coptidis 80g Radix Scutellariae 200g Pericarpium Citri Reticulatae 200g Rhizoma Pinelliae Preparatum 240g
Poria 300g Rhizoma Atractylodis Macrocephalae 300g Semen Coicis 400g Radix Glycyrrhizae Preparata 200g
Rhizoma Curcumae 300g Herba Agrimoniae 300g Radix Rubiae 60g Endoconcha Sepiae 400g
Bulbus Fritillariae Thunbergii 200g
Get whole 13 flavor medical materials, extracting in water twice, the water that add 31800g the first time extracted 2 hours, added the water of 25440g for the second time, extracted 2 hours; Merge extractive liquid,, relative density is 1.23 extractum when being concentrated into 80 ℃, adding ethanol to the concentration of volume percent that contains the alcohol amount is 56%, stir and spare, left standstill 18 hours, filter, relative density was 1.26 extractum when filtrate was concentrated into 80 ℃, namely got described active component.
Active component is mixed with an amount of sucrose and antiseptic, add water to 3000g, namely get oral liquid of the present invention.
Embodiment 4
Rhizoma Coptidis 120g Radix Scutellariae 100g Pericarpium Citri Reticulatae 100g Rhizoma Pinelliae Preparatum 100g
Poria 200g Rhizoma Atractylodis Macrocephalae 200g Semen Coicis 300g Radix Glycyrrhizae Preparata 100g
Rhizoma Curcumae 200g Herba Agrimoniae 200g Radix Rubiae 90g Endoconcha Sepiae 300g
Bulbus Fritillariae Thunbergii 100g
Get whole 13 flavor medical materials, extracting in water twice, the water that add 16880g the first time extracted 1.5 hours, added the water of 18990g for the second time, extracted 2.5 hours; Merge extractive liquid,, relative density is 1.22 extractum when being concentrated into 80 ℃, adding ethanol to the concentration of volume percent that contains the alcohol amount is 53%, stir and spare, left standstill 16 hours, filter, relative density was 1.28 extractum when filtrate was concentrated into 80 ℃, namely got described active component.
Active component is mixed with an amount of sucrose, granulation, drying namely gets granule of the present invention.
Embodiment 5
Rhizoma Coptidis 140g Radix Scutellariae 270g Pericarpium Citri Reticulatae 300g Rhizoma Pinelliae Preparatum 280g
Poria 400g Rhizoma Atractylodis Macrocephalae 400g Semen Coicis 500g Radix Glycyrrhizae Preparata 300g
Rhizoma Curcumae 400g Herba Agrimoniae 400g Radix Rubiae 90g Endoconcha Sepiae 500g
Bulbus Fritillariae Thunbergii 300g
Get whole 13 flavor medical materials, extracting in water twice, the water that add 47080g the first time extracted 2.5 hours, added the water of 29960g for the second time, extracted 1.8 hours; Merge extractive liquid,, relative density is 1.25 extractum when being concentrated into 80 ℃, adding ethanol to the concentration of volume percent that contains the alcohol amount is 58%, stir and spare, left standstill 12～24 hours, filter, relative density was 1.23 extractum when filtrate was concentrated into 80 ℃, namely got described active component.
Active component is put 70 ℃ of dryings in the vacuum drying oven, pulverized 100 mesh sieves, add appropriate amount of starch, silicon dioxide, magnesium stearate, granulation, drying incapsulates, and namely gets capsule of the present invention.
Embodiment 6
Rhizoma Coptidis 50g Radix Scutellariae 90g Pericarpium Citri Reticulatae 90g Rhizoma Pinelliae Preparatum 90g
Poria 150g Rhizoma Atractylodis Macrocephalae 150g Semen Coicis 260g Radix Glycyrrhizae Preparata 240g
Rhizoma Curcumae 250g Herba Agrimoniae 250g Radix Rubiae 130g Endoconcha Sepiae 260g
Bulbus Fritillariae Thunbergii 240g
Get whole 13 flavor medical materials, clean, drying and sterilizing is pulverized, and crosses 80 orders～l20 mesh sieve, incapsulates, and get final product.
Embodiment 7
The clinical trial situation of Chinese medicine of the present invention:
1, case is selected, patient age scope, course of disease time
Choose Patients with Chronic Gastritis 120 examples, be divided at random 2 groups.Treatment group 60 examples, male 35 examples, women 25 examples; Age 18-70 year, average 46.5 years old; The course of disease 10 week-2 year, average 1.65.Matched group 60 examples, male 34 examples, women 26 examples; Age 19-69 year, average 45.8 years old; The course of disease 10 week-2.5 year, average 1.71.
2, diagnostic criteria brief introduction
(tentative program) is dialectical is spleen and stomach damp-heat type for " chronic gastritis combination of Chinese and Western medicine diagnosis, the dialectical and criterion of therapeutical effect " formulated with reference to Chinese Association of the Integration of Traditional Chinese Medicine and Western Medicine digestive system disease Professional Committee.Clinical manifestation: epigastrium or scorching hot, the distending pain of gastral cavilty feeling of fullness, belch, or pantothenic acid, bitter taste, halitosis, red tongue, yellow fur is thick or greasy.Gastroscopy: see the obvious edema of gastric mucosa, hyperemia, erosion under the scope.
3, curative effect determinate standard:
With reference to " chronic gastritis combination of Chinese and Western medicine diagnosis, dialectical and criterion of therapeutical effect " (tentative program), clinical recovery: clinical cardinal symptom all disappears, and gastroscope check Active inflammation disappears, and chronic inflammatory disease is pass on well slightly.Produce effects: clinical cardinal symptom disappears, and inferior disease disappears substantially, and gastroscope check Active inflammation disappears substantially, and chronic inflammatory disease takes a turn for the better.Effectively: cardinal symptom obviously alleviates.Gastroscope check mucosa extent of disease dwindles more than 1/2, and inflammation alleviates to some extent.Invalid: symptom is without change, and gastroscopy does not reach effective standard, also without deterioration person.
4, drug use method
Treatment group: take the medicine of the embodiment of the invention 3, every day twice, ante cibum 30, min was oral, each serving using the medicine that is equivalent to crude drug amount 20g.
Matched group: omeprazole enteric-coated capsules (Kunshan dragon lantern Rui Di pharmaceutical Co. Ltd, the accurate word H20033373 of traditional Chinese medicines) 20 mg, every day 2 times, ante cibum 30, min was oral.
5, the clinical treatment result gathers with form
5.1 two groups of Clinical efficacy comparisons see Table 1.
2 groups of Clinical efficacy comparisons of table l
| Group | n | Clinical recovery | Produce effects | Effectively | Invalid | Total effective rate % |
| Treatment group | 60 | 32 | 21 | 5 | 2 | 96.7* |
| Matched group | 60 | 21 | 14 | 16 | 9 | 85 |
Compare * P＜0.05 with matched group
By as seen from Table 1, two groups always have the effective percentage comparing difference that statistical significance (P＜0.05) is arranged, and the treatment group curative effect is better than matched group.
5.2 symptom integral relatively sees Table 2 before and after two groups of treatments.
Symptom integral relatively before and after the table 2 liang group treatment
Relatively front with the treatment of this group, * P＜0.05; With comparison after the treatment of control group, #P＜0.05
By as seen from Table 2, treat rear each symptom integral for 2 groups and all obviously reduce, with comparing difference before the treatment statistical significance (P＜0.05) is arranged all; The treatment after 2 groups except epigastric upset, bitter taste xerostomia, all the other symptom integral comparing differences all have statistical significance (P＜0.05), treatment group is lower than matched group.
5.3 two groups of two groups of relapse rate comparisons all followed up a case by regular visits to for 12 weeks, treatment group 60 examples are cured 32 examples, recur 3 examples, account for 9.4%; Matched group 60 examples are cured the 2l example, recur 7 examples, account for 33.3%.2 groups of relapse rate comparing differences have statistical significance (P＜0.05), and treatment group is lower than matched group.
5.4 constipation 2 examples appear in untoward reaction treatment group 60 examples, 2 examples of suffering from diarrhoea, and taupe is 1 example just; Insomnia 3 examples appear in matched group 60 examples, 4 examples of suffering from abdominal pain, and pitchy is 1 example just.In 2 weeks, two groups of untoward reaction all disappeared after finished 2 courses for the treatment of.
Embodiment 8
1, Wei *, the man, 56 years old, people from Liucheng County, Guangxi, case history 6 years, the scorching hot dull pain of symptom gastral cavilty section 6 years, bitter taste, dry pharynx, constipation with dry stool is difficult to resolve, 3-5 days 1 row, red tongue, yellow and greasy fur, the People's Hospital's outpatient service is interrupted medical, gastroscopy is shown: chronic erosive gastritis.Oral " rabeprazole enteric coated capsule " 20mg, bid, bad during the symptom fashion; Execute through medicine of the present invention and to control, treat after 14 days symptom and obviously alleviate, follow up a case by regular visits to and have no recurrence half a year.”
2, yellow *, the woman, 26 years old, people from Guilin, case history 1 year, symptom gastral cavilty feeling of fullness distending pain, belch, halitosis, red tongue, yellow fur is thick.The local hospital outpatient service is interrupted medical, and gastroscopy is shown: chronic superficial gastritis.Oral " domperidone tablet " 10 mg, every day 3 times, bad during the symptom fashion; Execute through medicine of the present invention and to control, treat after 7 days symptom and obviously alleviate, follow up a case by regular visits to and had no recurrence in 1 year.”
3, " high *, the man, 38 years old, Guangxi San Jiangxian people, case history 10 years, the scorching hot distending pain of symptom gastral cavilty section 10 years, bitter taste, dry pharynx, constipation with dry stool is difficult to resolve, and 2 days 1 row, red tongue, yellow and greasy fur, local hospital are interrupted medical (concrete medication is not quite clear), and symptom has no alleviation; Execute through medicine of the present invention and to control, treat after 18 days symptom and obviously alleviate, follow up a case by regular visits to and have no recurrence half a year.”
4, old *, the man, 56 years old, people from Liuzhou, case history 3 years, the scorching hot dull pain of symptom gastral cavilty section 3 years, bitter taste, dry pharynx, constipation with dry stool is difficult to resolve, 1 day 1 row, red tongue, yellow fur is thick, workers' hospital's outpatient service is interrupted medical, gastroscopy is shown: chronic erosive gastritis.Oral " rabeprazole enteric coated capsule " 10mg, bid, bad during the symptom fashion; Execute through medicine of the present invention and to control, treat after 14 days symptom and obviously alleviate, follow up a case by regular visits to and have no recurrence half a year.”
5, " Liu *, the woman, 65 years old, people from Liujiang County, Guangxi, case history July, the scorching hot dull pain of symptom gastral cavilty section 2 years, bitter taste, belch, dry pharynx, stool is still transferred, red tongue, yellow fur, the Liujiang hospital outpatient is interrupted medical, and gastroscopy is shown: chronic erosive gastritis.Oral " rabeprazole enteric coated capsule " 20mg, bid, " amoxicillin 0.5g, every day 2 times, bad during the symptom fashion; Execute through medicine of the present invention and to control, treat after 15 days symptom and obviously alleviate, follow up a case by regular visits to and have no recurrence half a year.”
Claims (7)
1. Chinese medicine for the treatment of chronic gastritis is characterized in that it is to be prepared from by the raw material that comprises following weight portion:
Rhizoma Coptidis 3～20 Radix Scutellariaes 5～40 Pericarpium Citri Reticulataes 5～40 Rhizoma Pinelliae Preparatum 5～40
Poria 10～50 Rhizoma Atractylodis Macrocephalaes 10～50 Semen Coiciss 20～60 Radix Glycyrrhizae Preparata 5～40
Rhizoma Curcumae 10～50 Herba Agrimoniaes 10～50 Radix Rubiaes 2～15 Endoconcha Sepiaes 20～60
Bulbus Fritillariae Thunbergii 5～40.
2. the Chinese medicine for the treatment of chronic gastritis as claimed in claim 1 is characterized in that it is to be prepared from by the raw material that comprises following weight portion:
Rhizoma Coptidis 5～15 Radix Scutellariaes 10～30 Pericarpium Citri Reticulataes 10～30 Rhizoma Pinelliae Preparatum 10～30
Poria 20～40 Rhizoma Atractylodis Macrocephalaes 20～40 Semen Coiciss 30～50 Radix Glycyrrhizae Preparata 10～30
Rhizoma Curcumae 20～40 Herba Agrimoniaes 20～40 Radix Rubiaes 3～9 Endoconcha Sepiaes 30～50
Bulbus Fritillariae Thunbergii 10～30.
3. the Chinese medicine for the treatment of chronic gastritis as claimed in claim 2 is characterized in that it is to be prepared from by the raw material that comprises following weight portion:
Rhizoma Coptidis 8 Radix Scutellariaes 20 Pericarpium Citri Reticulataes 20 Rhizoma Pinelliae Preparatum 24
Poria 30 Rhizoma Atractylodis Macrocephalaes 30 Semen Coiciss 40 Radix Glycyrrhizae Preparata 20
Rhizoma Curcumae 30 Herba Agrimoniaes 30 Radix Rubiaes 6 Endoconcha Sepiaes 40
Bulbus Fritillariae Thunbergii 20.
4. the Chinese medicine for the treatment of chronic gastritis as claimed in claim 1 is characterized in that its active component is prepared from by the following method:
Get whole 13 flavor medical materials, extracting in water twice adds the water that is equivalent to 6～12 times of medical material gross weights for the first time, extracts 1～3 hour, adds for the second time the water that is equivalent to 6～12 times of medical material gross weights, extracts 1～3 hour; Merge extractive liquid,, relative density is 1.20～1.26 extractum when being concentrated into 80 ℃, adding ethanol to the concentration of volume percent that contains the alcohol amount is 50%～60%, stir even, left standstill 12～24 hours, filter, relative density was 1.22～1.30 extractum when filtrate was concentrated into 80 ℃, namely got described active component.
5. the Chinese medicine for the treatment of chronic gastritis as claimed in claim 1 is characterized in that its active component is prepared from by the following method:
Get whole 13 flavor medical materials, extracting in water twice adds the water that is equivalent to 8～10 times of medical material gross weights for the first time, extracts 2 hours, adds for the second time the water that is equivalent to 8～10 times of medical material gross weights, extracts 2 hours; Merge extractive liquid,, relative density is 1.23 extractum when being concentrated into 80 ℃, adding ethanol to the concentration of volume percent that contains the alcohol amount is 56%, stir and spare, left standstill 12～24 hours, filter, relative density was 1.26 extractum when filtrate was concentrated into 80 ℃, namely got described active component.
6. the Chinese medicine for the treatment of chronic gastritis as claimed in claim 1 is characterized in that its capsule is prepared from by the following method:
Get whole 13 flavor medical materials, clean, drying and sterilizing is pulverized, and crosses 80 orders～l20 mesh sieve, incapsulates, and get final product.
7. a Chinese medicine preparation for the treatment of chronic gastritis comprises the Chinese medicine of each treatment chronic gastritis in the claim 1～6 and pharmaceutically acceptable carrier.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104398736A (en) * | 2014-11-05 | 2015-03-11 | 崔银方 | Pharmaceutical composition treating chronic gastritis and preparation method thereof |
| CN104888041A (en) * | 2015-06-25 | 2015-09-09 | 沈健龙 | Traditional Chinese medicine composition for treatment of liver depression invading stomach type chronic gastritis |
| CN109481594A (en) * | 2019-01-10 | 2019-03-19 | 李锟 | A kind of stomach and intestine hemostasis defoaming bacteriostatic agent and preparation method thereof |
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| CN102670889A (en) * | 2012-05-03 | 2012-09-19 | 成都绿迪科技有限公司 | Chinese medicine for treating chronic gastritis |
| CN102727788A (en) * | 2012-07-06 | 2012-10-17 | 谭曜 | Chinese medicament for treating dampness-heat spleen and stomach type chronic gastritis |
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| CN102670889A (en) * | 2012-05-03 | 2012-09-19 | 成都绿迪科技有限公司 | Chinese medicine for treating chronic gastritis |
| CN102727788A (en) * | 2012-07-06 | 2012-10-17 | 谭曜 | Chinese medicament for treating dampness-heat spleen and stomach type chronic gastritis |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104398736A (en) * | 2014-11-05 | 2015-03-11 | 崔银方 | Pharmaceutical composition treating chronic gastritis and preparation method thereof |
| CN104888041A (en) * | 2015-06-25 | 2015-09-09 | 沈健龙 | Traditional Chinese medicine composition for treatment of liver depression invading stomach type chronic gastritis |
| CN109481594A (en) * | 2019-01-10 | 2019-03-19 | 李锟 | A kind of stomach and intestine hemostasis defoaming bacteriostatic agent and preparation method thereof |
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| CN103055257B (en) | 2014-06-11 |
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