CN103048433A - Convenient holding type dissolution cup of dissolution tester - Google Patents
Convenient holding type dissolution cup of dissolution tester Download PDFInfo
- Publication number
- CN103048433A CN103048433A CN2012101454799A CN201210145479A CN103048433A CN 103048433 A CN103048433 A CN 103048433A CN 2012101454799 A CN2012101454799 A CN 2012101454799A CN 201210145479 A CN201210145479 A CN 201210145479A CN 103048433 A CN103048433 A CN 103048433A
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- China
- Prior art keywords
- cup
- dissolution
- dissolution rate
- convenient
- stripping rotor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Links
- 238000004090 dissolution Methods 0.000 title claims abstract description 34
- 239000011241 protective layer Substances 0.000 claims description 12
- 235000019994 cava Nutrition 0.000 claims description 6
- 239000011521 glass Substances 0.000 claims description 5
- 239000000463 material Substances 0.000 claims description 4
- 238000003756 stirring Methods 0.000 abstract description 11
- 101100327917 Caenorhabditis elegans chup-1 gene Proteins 0.000 description 13
- 239000003814 drug Substances 0.000 description 8
- 238000012360 testing method Methods 0.000 description 7
- 230000029087 digestion Effects 0.000 description 5
- 238000005516 engineering process Methods 0.000 description 5
- 238000000034 method Methods 0.000 description 5
- 239000000203 mixture Substances 0.000 description 5
- 238000002360 preparation method Methods 0.000 description 5
- 239000007787 solid Substances 0.000 description 5
- 230000015572 biosynthetic process Effects 0.000 description 4
- 229940079593 drug Drugs 0.000 description 4
- 238000009472 formulation Methods 0.000 description 4
- 238000004519 manufacturing process Methods 0.000 description 4
- 239000000825 pharmaceutical preparation Substances 0.000 description 3
- 238000013461 design Methods 0.000 description 2
- 238000007922 dissolution test Methods 0.000 description 2
- 238000007689 inspection Methods 0.000 description 2
- 239000003504 photosensitizing agent Substances 0.000 description 2
- 239000002775 capsule Substances 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 210000000936 intestine Anatomy 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000002075 main ingredient Substances 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 238000003908 quality control method Methods 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 238000011287 therapeutic dose Methods 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
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- Investigating Or Analysing Biological Materials (AREA)
Abstract
The invention discloses a convenient holding type dissolution cup of a dissolution tester. The dissolution cup comprises a cup body, wherein the bottom of the cup body is inwards concave to form a cone bottom, and the side wall of the cup body is provided with a slot. The bottom of the cup body is inwards concave to form the cone bottom, so a dead zone for stirring can not be formed when a paddle shaft is used for stirring at a central zone of the dissolution cup. Therefore, a sample can be uniformly dissolved in the dissolution cup, and the slot is convenient for the taking of the dissolution cup, and meanwhile, the internal circulation is strengthened.
Description
Technical field
The invention belongs to the pharmaceutical equipment field, particularly relate to the stripping rotor of being convenient to hold the dissolution rate tester of taking.
Background technology
Dissolution rate (Dissolution rate) also claim dissolution rate, refers under the solvent and condition of regulation speed and the degree of medicine stripping from the solid pharmaceutical preparations such as tablet, capsule, granule.The process of measuring the solid pharmaceutical preparation dissolution rate is called Dissolution Rate Testing (Dissolution test), and it is a kind of disintegration of oral solid formulation in intestines and stomach and in vitro test method of stripping simulated.The drug dissolution inspection is a kind of effective means of estimating preparation quality and technological level, the difference that can reflect to a certain extent crystal formation, granularity, prescription composition, auxiliary material kind and character, the production technology etc. of main ingredient, it also is a kind of effective standard of estimating preparation active component bioavilability and preparation uniformity coefficient, can effectively distinguish the difference of same drug bioavailability, therefore be one of drug quality control essential items for inspection.
It is generally acknowledged, slightly solubility (referring generally to slightly soluble or insoluble in water) medicine, because of the medicine (comprising soluble drug) that preparation prescription and production technology cause the unsettled medicine of clinical efficacy and therapeutic dose and dosis toxica to be close, must set the dissolution test item in its oral solid formulation quality standard.In the prescription screening of solid pharmaceutical preparation and the technological process of production formulation process, also need the dissolution rate of exploitation formulation is done comprehensive investigation in addition.Feasible Dissolution Rate Testing method should be all must reach test findings at different time, place to the mensuration between the dissolution determination of same preparation or the different operator to have good reappearance.
Therefore, the digestion instrument that is used for the dissolution rate test is had very high requirement, to each small details good design should be arranged.At present, be convenient to hold the structure (as shown in Figure 1) of the stripping rotor of the dissolution rate tester of taking, the bottom of the cup 1 of stripping rotor is semisphere.When oar axle 2 stirred at the stripping rotor center, the center of this domed bottom was " dead band " 3 of stirring, and sample is inside and outside in this zone, the stripping of edge has significant difference.
Summary of the invention
Technical matters to be solved by this invention provides the stripping rotor of being convenient to hold the dissolution rate tester of taking, and there is not stirring " dead band " in the bottom of cup center of this stripping rotor, and the liquid in the stripping rotor forms the solution of homogeneous, improves the degree of accuracy that dissolution rate is measured.
The present invention solves the problems of the technologies described above the technical scheme that adopts: be convenient to hold the stripping rotor of the dissolution rate tester of taking, comprise cup, the bottom of the described cup formation conical bottom that caves inward is provided with groove on the sidewall of described cup.
Described groove is around the setting of rounding of the outer wall of cup.
In the technique scheme, the bottom of the cup formation conical bottom that caves inward when the oar axle stirs in the central area of stripping rotor, can not form stirring " dead band ", and therefore, sample can form the stripping of homogeneous in stripping rotor.
The outer wall at the rim of a cup place of described cup is arranged with protective layer, and described protective layer is along the setting of rounding of the outer wall of cup.
The rim of a cup place of described cup has past extension and turnup and the flange that forms, and described flange is arranged on the top of protective layer.
In the technique scheme, stripping rotor is fixed on the digestion instrument by flange.The contact site of stripping rotor and digestion instrument rounds protective layer is set.
Described cup is that the brown glass material consists of; The specification of described cup is 150 milliliters or 1200 milliliters.
Adopt brown glass, can carry out the dissolution rate test to photosensitizer.
In sum, the present invention compared with prior art has following advantage:
(1), the present invention arranges simple in structure, manufacturing cost is lower, groove can be conveniently to the fetching of stripping rotor, strengthen simultaneously inner circulation, be applicable to the scientific research departments such as each big-and-middle universities and colleges, medical treatment, health and epidemic prevention, environmental monitoring, pharmaceutical industry to the test of dissolution rate.
(2), the bottom of the cup formation conical bottom that caves inward, when the oar axle stirs in the central area of stripping rotor, can not form stirring " dead band ", therefore, sample can form uniform stripping in stripping rotor.
Description of drawings
Fig. 1 is the existing stripping rotor structural representation of describing in the background technology;
Fig. 2 is the surface structure synoptic diagram of the embodiment of the invention 1;
Fig. 3 is the structural representation of the embodiment of the invention 2.
The corresponding name of each parts is called among the figure: 1-cup, 2-oar axle.The 3-dead band, 4-flange, 5-protective layer, 6-conical bottom, 7-groove.
Embodiment
Below in conjunction with embodiment and accompanying drawing, the present invention is described in further detail, but embodiments of the present invention are not limited to this.
Embodiment 1:
Such as Fig. 2, be convenient to hold the stripping rotor of the dissolution rate tester of taking, be convenient to hold the stripping rotor of the dissolution rate tester of taking, comprise cup 1, the bottom of described cup 1 caves inward and forms conical bottom 6, is provided with groove 7 on the sidewall of described cup 1.Strengthened the circulation of stripping rotor inside by groove 7.
The bottom of cup 1 caves inward and forms conical bottom 6, when oar axle 2 stirs in the central area of stripping rotor, can not form stirring " dead band ", therefore, sample can form the stripping of homogeneous in stripping rotor, groove 7 can change the eddy current direction of cup 1 inside simultaneously, so that the better effects if that stirs.
Described groove 7 is around the setting of rounding of the outer wall of cup 1.
Described cup 1 consists of for the brown glass material; The specification of described cup 1 is 150 milliliters or 1200 milliliters.Adopt brown glass, can carry out the dissolution rate test to photosensitizer.The specification of cup 1 designs as required.
As shown in Figure 3, the structure of present embodiment and embodiment 1 is basic identical, and its difference only is: the outer wall at the rim of a cup place of described cup 1 is arranged with protective layer 5, and described protective layer 5 is along the setting of rounding of the outer wall of cup 1.The wall of cup of 5 pairs of stripping rotors of protective seam is protected, and prevents the phenomenon appearance such as scratch.
The rim of a cup place of described cup 1 has past extension and turnup and the flange 4 that forms, and described flange 4 is arranged on the top of protective layer 5.
When stripping rotor relies on flange when digestion instrument is located, the outer wall at rim of a cup place also is the contact site of stripping rotor and digestion instrument, protective layer 5 is set herein can protects stripping rotor, prolongs its serviceable life.
As mentioned above, just can realize preferably the present invention.
Claims (5)
1. be convenient to hold the stripping rotor of the dissolution rate tester of taking, comprise cup (1), the bottom of described cup (1) caves inward and forms conical bottom (6), it is characterized in that: be provided with groove (7) on the sidewall of described cup (1).
2. the stripping rotor of being convenient to hold the dissolution rate tester of taking according to claim 1 is characterized in that: described groove (7) is around the setting of rounding of the outer wall of cup (1).
3. the stripping rotor of being convenient to hold the dissolution rate tester of taking according to claim 1, it is characterized in that: the outer wall at the rim of a cup place of described cup (1) is arranged with protective layer (5), and described protective layer (5) is along the setting of rounding of the outer wall of cup (1).
4. the stripping rotor of being convenient to hold the dissolution rate tester of taking according to claim 3 is characterized in that: the rim of a cup place of described cup (1) has past extension and turnup and the flange (4) that forms, and described flange (4) is arranged on the top of protective layer (5).
5. each described stripping rotor of being convenient to hold the dissolution rate tester of taking according to claim 1-4 is characterized in that: described cup (1) is that the brown glass material consists of; The specification of described cup (1) is 150 milliliters or 1200 milliliters.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2012101454799A CN103048433A (en) | 2011-10-15 | 2012-05-11 | Convenient holding type dissolution cup of dissolution tester |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201110311939.6 | 2011-10-15 | ||
| CN201110311939 | 2011-10-15 | ||
| CN2012101454799A CN103048433A (en) | 2011-10-15 | 2012-05-11 | Convenient holding type dissolution cup of dissolution tester |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN103048433A true CN103048433A (en) | 2013-04-17 |
Family
ID=48061148
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2012101454799A Pending CN103048433A (en) | 2011-10-15 | 2012-05-11 | Convenient holding type dissolution cup of dissolution tester |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN103048433A (en) |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN2055740U (en) * | 1989-07-26 | 1990-04-11 | 煤炭科学研究总院唐山分院 | Stirring barrel with flow guiding ring seat |
| US5700087A (en) * | 1995-10-06 | 1997-12-23 | Beckett; Arnold H. | Device maximizing dispersion of aggregate in liquid diluent |
| US20020189378A1 (en) * | 1999-11-02 | 2002-12-19 | Duckett Gregory S. | Methods and apparatus for determining the location of a shaft within a vessel |
| CN201227101Y (en) * | 2008-07-21 | 2009-04-29 | 滕霖 | Multifunctional cup |
-
2012
- 2012-05-11 CN CN2012101454799A patent/CN103048433A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN2055740U (en) * | 1989-07-26 | 1990-04-11 | 煤炭科学研究总院唐山分院 | Stirring barrel with flow guiding ring seat |
| US5700087A (en) * | 1995-10-06 | 1997-12-23 | Beckett; Arnold H. | Device maximizing dispersion of aggregate in liquid diluent |
| US20020189378A1 (en) * | 1999-11-02 | 2002-12-19 | Duckett Gregory S. | Methods and apparatus for determining the location of a shaft within a vessel |
| CN201227101Y (en) * | 2008-07-21 | 2009-04-29 | 滕霖 | Multifunctional cup |
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| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C12 | Rejection of a patent application after its publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20130417 |