CN103040976B - Medicine for promoting postoperative rehabilitation of facial nerve injury surgical anastomosis - Google Patents
Medicine for promoting postoperative rehabilitation of facial nerve injury surgical anastomosis Download PDFInfo
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Abstract
The invention discloses a medicine for promoting postoperative rehabilitation of facial nerve injury surgical anastomosis, which solves the postoperative rehabilitation problem of facial nerve injury surgical anastomosis. The medicine is characterized by being processed by a plurality of traditional Chinese medicines and comprises following raw materials by weight ratio: 10 to 20 parts of sunglo, 8 to 15 parts of filipendula palmate, 8 to 15 parts of herb of glabrous sarcandra, 6-10 parts of cineraria repanda, 6 to 10 parts of pawpaw, 8 to 15 parts of pangolin, 6 to 10 parts of cimicifugae foetidae, 3 to 6 parts of cassia twig and 3 to 6 parts of lithocholic acid. Clinical trials prove that the medicine for promoting postoperative rehabilitation of facial nerve injury surgical anastomosis has the characteristics of good curative effect and higher safety, and is worth to be clinically applied and popularized.
Description
Technical field
The present invention relates to the field of Chinese medicines, be specifically related to a kind of medicine that promotes the postoperative rehabilitation of facial nerve injury surgical stapling.
Background technology
The incidence rate of craniocerebral injury companion facial nerve injury is about 3%, has the patient of external auditory meatus hemorrhage and discharge after wound, and wherein 1/5 can occur ipsilateral myasthenia.Its common cause is the fracture of middle cranial fossa petrous bone portion and mastoidea, and approximately there is the transverse fracture of 50% longitudinal fracture and the 25% VII injury of cranial nerve that occurs together in this portion.The longitudinal fracture parallel with talus cone major axis particularly, nervus facialis subjects to involve most, contusion or sclerite squeezing and cause early hair style or delayed facial paralysis.To lasting completeness facial paralysis, adopt of neurosurgery, substitute prosthesis, as facial accessory nerve anastomosis or facial-phrenic anastomosis more.Above-mentioned facial nerve injury Surgical anastomosis, postoperatively gives nerve growth factor to urge nerve growth rehabilitation more.But still have 10 ~ 15% the neural faulty restoration of patient, cannot reach operation Expected Results.
Summary of the invention
Technical assignment of the present invention is for above the deficiencies in the prior art, and the medicine of the sure postoperative rehabilitation of promotion facial nerve injury surgical stapling of a kind of curative effect is provided.
The technical scheme that the present invention solves its technical problem is: a kind of medicine that promotes the postoperative rehabilitation of facial nerve injury surgical stapling, it is characterized in that being processed by plurality of Chinese, its composition of raw materials and weight proportion are: 10 ~ 20 parts of Usneas, 8 ~ 15 parts of Herba Moslae Chinensis, 8 ~ 15 parts of Herba Sarcandraes, 6 ~ 10 parts of Herba Senecionis Scandentiss, 6 ~ 10 parts of Fructus Chaenomeliss, 8 ~ 15 parts of Squama Maniss, 6 ~ 10 parts of Rhizoma Cimicifugaes, 3 ~ 6 parts of Ramulus Cinnamomi, 3 ~ 6 parts, stone gallbladder.
Its optimum weight proportioning is: 15 parts of Usneas, 10 parts of Herba Moslae Chinensis, 10 parts of Herba Sarcandraes, 8 parts of Herba Senecionis Scandentiss, 8 parts of Fructus Chaenomeliss, 10 parts of Squama Maniss, 8 parts of Rhizoma Cimicifugaes, 5 parts of Ramulus Cinnamomi, 5 parts, stone gallbladder.
Wherein said: Usnea is the thallus (thallus) of Usneaceae Usnea plant USNEA Usnea diffracta (female trailing plants, Herba Cucubali) Usnea diffracta Vain. or Usnea Longissima (Scolopendra Usnea, Herba Stellariae Alsines) U. longissima Ach..Nature and flavor are sweet, flat.Merit can heat-clearing and toxic substances removing, hemostasia and promoting granulation, and pain relieving, liver heat removing and eyesight improving, moves back nebula.
Herba Moslae Chinensis is the herb of labiate Mosla chinensis Maxim. Bulbophyllum reptans Lindl..Nature and flavor are arduous, temperature.Merit can be driven away summer heat, and invigorates blood circulation, regulate the flow of vital energy, and removing dampness.
Herba Sarcandrae is the dry Herb of Chloranthaceae plant plait Corallium Japonicum Kishinouye Sarcandra glabra (Thunb.) Nakai.Bitter, pungent, flat.GUIXIN, Liver Channel.Merit can clearing away heat and cooling blood, the speckle removing of invigorating blood circulation, dispelling wind and removing obstruction in the collateral.
Herba Senecionis Scandentis is Compositae Senecio plant Herba Senecionis Scandentis Senecio scandens Buch.-Ham., with all herbal medicine.Cold in nature, bitter in the mouth.Merit can heat-clearing and toxic substances removing, removing heat from blood detumescence, removing obstruction for relieving pain.
Fructus Chaenomelis is the dry almost ripe fruit of rosaceous plant chaenomeles lagenaria Chaenomeles speciosa.Nature and flavor acid, temperature.Return liver, spleen channel.Merit can suppressing the hyperactive liver relaxing muscles and tendons, stomach function regulating removing dampness.
Squama Manis is the scute of Manidae animal Squama Manis Manis pentadactyla Linnaeus.Nature and flavor are salty, are slightly cold.Return liver, stomach warp.The merit stimulating milk secretion of can stimulating the menstrual flow, detumescence and apocenosis, expel wind to dredge collateral.
Rhizoma Cimicifugae is ranunculaceae plant C.heracleifolia Cimicifuga heracleifolia Kom., Cimicifuga Dahurica Cimicifuga dahurica (Turcz.) Maxim. or the dry rhizome of Rhizoma Cimicifugae Cimicifuga foetida L..Nature and flavor are pungent, micro-sweet, are slightly cold.Return lung, spleen, stomach, large intestine channel.Merit can be delivered rash, heat-clearing and toxic substances removing, elevate a turnable ladder yang-energy.
Ramulus Cinnamomi is the withe of canella Cortex Cinnamomi Cinnamomum cassia Presl.Nature and flavor acrid, sweet, warm.Enter the heart, lung, urinary bladder channel.Merit can relieving the exterior syndrome by diaphoresis, promoting the flow of QI-blood by warming the meridian, activating YANG and prormoting functioning of QI.
Stone gallbladder is natural or made aqueous sulfuric acid copper crystalline solid.Sour, pungent, cold.Removing the necrotic tissue; Removing toxic substances.
The present invention compared with the prior art, has following characteristics.
1, prescription is unique: the pathogenesis for the short nerve growth of facial nerve injury Surgical anastomosis is started with, and dredging collateral dispels the wind, suppressing the hyperactive liver relaxing muscles and tendons, and assistant is with removing pathogenic heat from blood and toxic substance from the body.Prescription avoids using special blood circulation promoting medicine, as Radix Salviae Miltiorrhizae, Radix Paeoniae Rubra, Radix Angelicae Sinensis, Flos Carthami etc., because said medicine is too moved blood, easily strengthens the risk of postoperative hemorrhage; Avoid using the medicine of soothing the liver circulation of qi promoting, as Radix Bupleuri, Cornu Saigae Tataricae, Ramulus Uncariae Cum Uncis, Radix Curcumae etc., its reason is the capable loose consumption gas of such medicine, is unfavorable for post-operative recovery.
2, Usnea, Herba Moslae Chinensis, Herba Sarcandrae three herbal medicines share the merit that plays altogether regulating qi and dredging collateral, regulate the flow of vital energy different from circulation of qi promoting, without the anxiety of dissipation, so-called dredging collateral, for medicine channels helps the meaning of its operation; Dredging collateral medicine has logical extremity channels, Tongxinluo, logical liver and gall network, logical spleen kidney network etc., and Usnea, Herba Moslae Chinensis the two enter Liver Channel, logical liver network, so selecting this two medicine is monarch drug; it is dispelling summer-heat and dampness medicine that Herba Moslae Chinensis " pharmacopeia " is recorded originally, but postoperative rehabilitation has special effect for facial nerve injury surgical stapling, can alleviate rapidly neural Xun Hang position sense of discomfort, and coordinate the liver heat removing pain relieving of Usnea, amount to sun clearly and rise the merit that turbid yin falls; Herba Sarcandrae clearing away heat and cooling blood, the speckle removing of invigorating blood circulation, can promote neural reparation effectively.
3, supplementary drug thing: Herba Senecionis Scandentis removing heat from blood detumescence is got by side, removing obstruction for relieving pain, this medicine feature is cold and solidifying, loose and do not consume, and is suitable for the postoperative use of neural anastomosis; Fructus Chaenomelis suppressing the hyperactive liver relaxing muscles and tendons, can also alleviate due to postoperative nervous of facial nerve injury surgical stapling; It is strong that Squama Manis walks to alter power, enters liver stomach expel wind to dredge collateral; Rhizoma Cimicifugae elevate a turnable ladder yang-energy.
4, using corrigent: use Ramulus Cinnamomi promoting the flow of QI-blood by warming the meridian, activating YANG and prormoting functioning of QI, belongs to using corrigent, this using corrigent, except activating yang network, also has the meaning of pregnant sun in the moon.
5, stone gallbladder is aqueous sulfuric acid copper crystalline solid, in we, uses, and is to separate out copper ion in its decoction process, experiment showed, that copper ion can increase our drug effect.
6, medicine material consumption of the present invention is groped in a large number to sum up through inventor and is drawn, each raw material consumption is for all to have good curative effect in following weight parts scope.
The specific embodiment
Below in conjunction with practical situation, the specific embodiment of the present invention is elaborated.
Embodiment 1, crude drug weight proportion: Usnea 10g, Herba Moslae Chinensis 8g, Herba Sarcandrae 8g, Herba Senecionis Scandentis 6g, Fructus Chaenomelis 6g, Squama Manis 8g, Rhizoma Cimicifugae 6g, Ramulus Cinnamomi 3g, stone gallbladder 3g.
Embodiment 2, crude drug weight proportion: Usnea 20g, Herba Moslae Chinensis 15g, Herba Sarcandrae 15g, Herba Senecionis Scandentis 10g, Fructus Chaenomelis 10g, Squama Manis 15g, Rhizoma Cimicifugae 10g, Ramulus Cinnamomi 6g, stone gallbladder 6g.
Embodiment 3, crude drug weight proportion: Usnea 15g, Herba Moslae Chinensis 10g, Herba Sarcandrae 10g, Herba Senecionis Scandentis 8g, Fructus Chaenomelis 8g, Squama Manis 10g, Rhizoma Cimicifugae 8g, Ramulus Cinnamomi 5g, stone gallbladder 5g.
During use, Chinese medicine Usnea of the present invention, Herba Moslae Chinensis, Herba Sarcandrae, Herba Senecionis Scandentis, Fructus Chaenomelis, Squama Manis, Rhizoma Cimicifugae, stone gallbladder, Ramulus Cinnamomi are decocted with water to twice, merging filtrate, a minute morning and evening takes.Or make the dosage forms such as oral liquid and use.
Effective combination of said medicine, coordinates mutually, can effectively reach the object of the postoperative rehabilitation of facial nerve injury surgical stapling, and side effect is less.The above results is that clinical data fully proves, interrelated data is as follows, and wherein drugs use is the crude drug weight proportion in embodiment 3.
1 object and method.
1.1 objects: be in January, 2008 ~ 2011 year JIUYUE facial nerve injury patient 42 examples, patient is row facial nerve injury Surgical anastomosis all, and the equal nutriture of each case is good, and blood glucose, blood fat and hepatic and renal function are all in normal range.
1.2 method.
1.2.1 research method: 42 routine patients are divided into matched group 22 example and experimental group 20 examples at random, and matched group gives conventional aftertreatment and nursing; Experimental group gives the embodiment of the present invention 3 gained extract orals on matched group basis.
1.2.2 safety evaluatio: all carry out the monitorings such as blood, urine, stool routine, liver, renal function, electrocardiogram before and after medication.
1.2.3 statistical analysis: carry out statistical analysis with SPSS 13.0, P < 0.05 indicates significant.
2 results.
There is the performance of electric reacting positive in patient 2.1 therapeutic evaluatioies: after treatment 7d, matched group has 27.27%(6/22), treatment group has 55.00%(11/20) patient there is electric reacting positive performance, two groups of comparisons, obvious difference (P < 0.05); 14d after treatment, this positive rate is 63.64%(14/22) and 80.00%(16/20), two groups of comparisons, obvious difference (P < 0.05).
2.2 untoward reaction: the untoward reaction that obvious medicine is relevant does not appear in treatment group.
3. conclusion.
The prompting of this result of study, the postoperative rehabilitation of facial nerve injury surgical stapling of the present invention has good effect and the higher feature of safety, clinic application, popularization.
Claims (2)
1. a medicine that promotes the postoperative rehabilitation of facial nerve injury surgical stapling, it is characterized in that, its composition of raw materials and weight proportion are: 10 ~ 20 parts of Usneas, 8 ~ 15 parts of Herba Moslae Chinensis, 8 ~ 15 parts of Herba Sarcandraes, 6 ~ 10 parts of Herba Senecionis Scandentiss, 6 ~ 10 parts of Fructus Chaenomeliss, 8 ~ 15 parts of Squama Maniss, 6 ~ 10 parts of Rhizoma Cimicifugaes, 3 ~ 6 parts of Ramulus Cinnamomi, 3 ~ 6 parts, Chalcanthitum; Its preparation method is for to decoct with water twice by Usnea, Herba Moslae Chinensis, Herba Sarcandrae, Herba Senecionis Scandentis, Fructus Chaenomelis, Squama Manis, Rhizoma Cimicifugae, Chalcanthitum, Ramulus Cinnamomi, and merging filtrate, divides and sooner or later take.
2. a kind of medicine that promotes the postoperative rehabilitation of facial nerve injury surgical stapling according to claim 1, is characterized in that its weight proportion is: 15 parts of Usneas, 10 parts of Herba Moslae Chinensis, 10 parts of Herba Sarcandraes, 8 parts of Herba Senecionis Scandentiss, 8 parts of Fructus Chaenomeliss, 10 parts of Squama Maniss, 8 parts of Rhizoma Cimicifugaes, 5 parts of Ramulus Cinnamomi, 5 parts, Chalcanthitum.
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| CN103405651A (en) * | 2013-08-19 | 2013-11-27 | 陈霞 | Preparation method of ointment for ulnar nerve injury |
| CN103463419A (en) * | 2013-08-19 | 2013-12-25 | 庞尊钊 | Preparation method of ointment used for peripheral nerve injury postoperative repair |
| CN103432385B (en) * | 2013-08-19 | 2015-04-22 | 庞尊钊 | Medicine for peripheral nerve injury postoperation recovery |
| CN104435733A (en) * | 2014-12-11 | 2015-03-25 | 青岛市市立医院 | Traditional Chinese medicine formula capable of promoting neurosurgry postoperative recovery |
| CN105412381A (en) * | 2015-12-10 | 2016-03-23 | 李龙 | Traditional Chinese medicine composition for healing of neurosurgical wounds |
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| JPS59222424A (en) * | 1983-06-01 | 1984-12-14 | Katsutaka Nagai | Remedy for disease of neuropathy |
| CN1785370A (en) * | 2005-11-15 | 2006-06-14 | 唐浩 | Medicine for treating facial paralysis spasm |
| ES2377785B2 (en) * | 2010-09-08 | 2012-09-26 | Universidad Miguel Hernández De Elche | PHARMACEUTICAL COMPOSITION FOR DRY EYE TREATMENT. |
| CN101972413B (en) * | 2010-10-22 | 2011-11-30 | 李柏文 | Traditional Chinese medicine for treating facial paralysis |
| CN102836305B (en) * | 2012-08-29 | 2014-03-05 | 邵连亭 | Traditional Chinese medicine formula of rehabilitation powder for facial neuritis |
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