CN103035471B - ESI ion source, for its controllable high-voltage DC power supply - Google Patents
ESI ion source, for its controllable high-voltage DC power supply Download PDFInfo
- Publication number
- CN103035471B CN103035471B CN201110293776.3A CN201110293776A CN103035471B CN 103035471 B CN103035471 B CN 103035471B CN 201110293776 A CN201110293776 A CN 201110293776A CN 103035471 B CN103035471 B CN 103035471B
- Authority
- CN
- China
- Prior art keywords
- voltage
- module
- ion source
- power supply
- output
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 238000001914 filtration Methods 0.000 claims abstract description 28
- 230000010355 oscillation Effects 0.000 claims abstract description 22
- 238000001514 detection method Methods 0.000 claims description 44
- 230000005684 electric field Effects 0.000 claims description 44
- 230000005669 field effect Effects 0.000 claims description 34
- 238000000889 atomisation Methods 0.000 claims description 16
- 238000012360 testing method Methods 0.000 claims description 10
- 230000000694 effects Effects 0.000 claims description 9
- 238000010438 heat treatment Methods 0.000 claims description 6
- 238000001035 drying Methods 0.000 claims description 3
- 239000007921 spray Substances 0.000 abstract description 6
- 230000005540 biological transmission Effects 0.000 abstract description 5
- 150000002500 ions Chemical class 0.000 description 100
- 239000007789 gas Substances 0.000 description 31
- 239000000523 sample Substances 0.000 description 13
- 239000000463 material Substances 0.000 description 6
- 239000000203 mixture Substances 0.000 description 5
- 230000008901 benefit Effects 0.000 description 4
- 238000010586 diagram Methods 0.000 description 4
- 238000000034 method Methods 0.000 description 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- 230000009471 action Effects 0.000 description 2
- 230000003321 amplification Effects 0.000 description 2
- 230000003750 conditioning effect Effects 0.000 description 2
- 238000010884 ion-beam technique Methods 0.000 description 2
- 238000003199 nucleic acid amplification method Methods 0.000 description 2
- 230000035945 sensitivity Effects 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 238000012512 characterization method Methods 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 230000001276 controlling effect Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 239000012634 fragment Substances 0.000 description 1
- 238000009434 installation Methods 0.000 description 1
- 230000000155 isotopic effect Effects 0.000 description 1
- 238000004949 mass spectrometry Methods 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 239000012488 sample solution Substances 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
Landscapes
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
- Dc-Dc Converters (AREA)
Abstract
The invention discloses a kind of for the ionogenic controllable high-voltage DC power supply of ESI, comprising: oscillation module, for carrying out self-oscillation to generate switching signal; Switch module, for alternate conduction under the control of switching signal to export initial alternating voltage; Boost module, for being boosted by initial alternating voltage, obtains secondary alternating voltage; Voltage doubling rectifier module, for boosting according to preset multiple to secondary alternating voltage, and carries out rectification with output dc voltage by the voltage after boosting; Filtration module, for carrying out filtering by direct voltage; Output module, for the direct voltage after output filtering.The invention also discloses a kind of ESI ion source.The present invention, by providing high voltage and highfield to electric spray ion source, can significantly improve the ionizing efficiency to sample and the efficiency of transmission producing ion.
Description
Technical field
The present invention relates to mass spectrometry art field, particularly a kind of ESI ion source, and for the ionogenic controllable high-voltage DC power supply of ESI.
Background technology
Mass spectrometer also known as mass spectrograph, be for separating of with detection different isotopic instrument.Specifically, mass spectrometer is the principle that can deflect at elect magnetic field according to charged particle, carries out a quasi-instrument of separation and detection material composition by the mass discrepancy of material atom, molecule or molecular fragment.
Mass spectrometer is primarily of ion source, electro-ionic osmosis and ion transfer, mass analyzer, detector and vacuum system composition.Ion source is mass spectrometric important component part, its effect is that analyzed ionized sample molecule is become charged ion, and make these ions under the effect of ion optics, accumulate the ion beam with certain geometrical shape and certain energy, then enter mass analyzer separated.
Ion source makes neutral atom or molecular ionization, and therefrom draw the device of ion beam current.ESI (Electron SprayIonization, electric spray ion source) ion source is ionogenic one.The ionogenic operation principle of ESI when to be sample solution flow out from the Capillary with atomization gas sleeve pipe electric field and atomization gas blow band effect be sprayed into countless charged microlayer model.Under certain heating-up temperature, the solvent in drop is by rapid evaporation, and liquid-drop diameter constantly diminishes, and surface charge density constantly increases, and finally makes solvent and sample ions be squeezed from drop, and sample ions enters into the analyzed detection of rear class by capillary.
ESI ion source needs to apply the electric field of some strength, forms stable taylor cone (Taylor Cone) for maintaining ESI ion source, thus realizes sample and ionize to greatest extent.Further, the sample ions that ESI ion source produces, needs under certain electric field action, could assemble importing capillary efficiently.As from the foregoing, need to provide an applicable electric field to ion source.Traditional mass spectrometer lacks the real-time control to electric spray ion source electric field, and be unfavorable for being optimized adjustment to it, this will have a strong impact on Ionization Efficiency, and even the sensitivity of mass spectrometer.
Summary of the invention
Object of the present invention is intended at least solve one of above-mentioned technological deficiency.
For this reason, first object of the present invention is to provide a kind of for the ionogenic high-voltage DC power supply of ESI, and this high-voltage DC power supply can externally provide stable high voltage and highfield.
Second object of the present invention is to provide a kind of ESI ion source, and this ESI ion source, by providing high voltage and highfield to electric spray ion source, can significantly improve the ionizing efficiency to sample and the efficiency of transmission producing ion.
For achieving the above object, the embodiment of first aspect present invention proposes a kind of for the ionogenic high-voltage DC power supply of ESI, and comprising: oscillation module, described oscillation module is used for carrying out self-oscillation to generate switching signal; Switch module, described switch module is connected with described oscillation module, for alternate conduction under the control of described switching signal to export initial alternating voltage; Boost module, described boost module is connected with described switch module, for being boosted by described initial alternating voltage, obtains secondary alternating voltage; Voltage doubling rectifier module, described voltage doubling rectifier module is connected with described boost module, for boosting according to preset multiple to described secondary alternating voltage, and the voltage after boosting is carried out rectification with output dc voltage; Filtration module, described filtration module is connected with described voltage doubling rectifier module, for described commutating voltage is carried out filtering; Output module, described output module is connected with described filtration module, for exporting described filtered direct voltage.
According to the embodiment of the present invention for the ionogenic high-voltage DC power supply of ESI, can to the high voltage of ESI ion source stable output and highfield, to make to form High Voltage electric field in the ionogenic ionization chamber of ESI.
In one embodiment of the invention, described oscillation module comprises multivibrator and d type flip flop.
In one embodiment of the invention, described multivibrator comprises cmos schmitt trigger.
In one embodiment of the invention, described switch module comprises the first field effect transistor and the second field effect transistor, wherein, the output of described oscillation module is connected with the grid of described first field effect transistor and the grid of described second field effect transistor respectively, and the drain electrode of described first field effect transistor and the drain electrode of described second field effect transistor export initial alternating voltage respectively.Adopt field effect transistor as switch, have the advantages that switching over speed is fast, highly sensitive.
In one embodiment of the invention, the input of described boost module is connected with the drain electrode of described second field effect transistor with the drain electrode of described first field effect transistor respectively, for described initial AC power being boosted, obtains secondary alternating voltage.
In one embodiment of the invention, described boost module is high frequency transformer, two taps of the primary side of described high frequency transformer are connected with the drain electrode of described second field effect transistor with the drain electrode of described first field effect transistor respectively, and a tap of the primary side of described high frequency transformer is connected with described voltage multiplying rectifier unit.
In one embodiment of the invention, described filtration module is RC filter network.
In one embodiment of the invention, described high-voltage DC power supply comprises further: current detection module, and described current detection module is connected with a tap of the primary side of described boost module, for detecting the output current of described boost module; Voltage detection module, described voltage detection module is connected with the output of described filtration module, for the direct voltage after detection filter; Control module, described control module is connected with described voltage detection module with described current detection module respectively, for obtaining output current that described current detection module detects and the filtered direct voltage that described voltage detection module detects, in described control module, be preset with regulation voltage initial value; Voltage Regulator Module, the input of described Voltage Regulator Module is connected with the output of described control module with described filtration module respectively, the output of described Voltage Regulator Module is connected with the centre tap of the primary side of described boost module, for amplifying obtains the regulation voltage after adjusting by carrying out application condition from the described filtered direct voltage of described control module and described regulation voltage initial value, and the primary side regulation voltage after described adjustment being exported to described high frequency transformer is to regulate described initial alternating voltage.
Thus, can Real-Time Monitoring electric current and voltage, thus according to the different requirements to voltage and current, realize the adjustment to voltage and current.
In one embodiment of the invention, described high-voltage DC power supply comprises further: polarity adjustment module, the input of described polarity adjustment module and the output of described control module, the output of described polarity adjustment module respectively with the input of described current detection module, the input of described Voltage Regulator Module, the input of described voltage doubling rectifier module is connected, for two signals that output level is contrary, carry out low and high level by two signals contrary to described level to switch with to described Voltage Regulator Module, the polarity of the output signal of described current detection module and described voltage doubling rectifier module regulates.
Thus, the polarity of polarity adjustment module to the High Voltage electric field that high-voltage DC power supply output voltage is formed is utilized to regulate.
In one embodiment of the invention, described high-voltage DC power supply comprises further: turn off control module, the input of described shutoff control module is connected with described control module, the output of described shutoff control module is connected with described Voltage Regulator Module with described oscillation module respectively, turn off under the control of shutoff control signal that exports in described control module the switching signal that described switch module inputs to described boost module, and described Voltage Regulator Module inputs to the regulation voltage of described boost module.
Thus, shutoff is carried out to the partial function in high-voltage DC power supply 100 and controls, relatively large deviation can be there is at the voltage of current output and objective result, ensure that the accuracy of Output rusults.
The embodiment of second aspect present invention proposes a kind of ESI ion source, comprise: DC power supply group, described DC power supply group comprises the first controllable high-voltage DC power supply, the second controllable high-voltage DC power supply, the 3rd controllable high-voltage DC power supply, wherein, described first controllable high-voltage DC power supply, described second controllable high-voltage DC power supply and described 3rd controllable high-voltage DC power supply are the high-voltage DC power supply that first aspect present invention embodiment provides; Ion source cylinder, described ion source cylinder is connected with described first controllable high-voltage DC power supply, and described first controllable high-voltage DC power supply provides electric field to described ion source cylinder; Ion source soleplate, described ion source soleplate is connected with described second controllable high-voltage DC power supply, and described second controllable high-voltage DC power supply provides electric field to described ion source soleplate; ESI nozzle needle, described ESI nozzle needle is used for testing sample to be delivered in the cavity that described ion source cylinder and described ion source soleplate surround; Atomization gas sleeve pipe, described atomization gas casing pipe sleeve is located at the outside of described ESI nozzle needle, pass into atomization gas in the ionization cavity that surrounds to described ion source cylinder and described ion source soleplate, the electric field that the described ion source cylinder of described testing sample after access power supply and described ion source soleplate are formed and described atomization gas blow band effect under form charged microlayer model; Dry gas heater, passes into dry gas in described dry gas heater, and described dry gas heater is used for heating described dry gas; Dry gas sleeve pipe, described dry gas casing pipe sleeve is connected with described dry gas heater, be located at the outside of described ion source capillary and be connected with described ionization cavity, for the dry gas after described heating being passed into described ionization cavity to carry out drying to charged microlayer model, obtain charged ion; Ion source capillary, described ion source capillary is connected with described 3rd controllable high-voltage DC power supply, described ion source cylinder, described ion source soleplate and described ion source capillary after access power supply form focusing electric field, and described dried charged ion focuses on and is directed into described ion source capillary inlet under the effect of described focusing electric field.
According to the ESI ion source of the embodiment of the present invention, be applicable to provide high voltage and highfield to electric spray ion source battery lead plate, by the optimizing regulation to ion source internal electric field, the ionizing efficiency to testing sample and the efficiency of transmission producing ion can be improved significantly.
In one embodiment of the invention, the absolute value of the voltage of electric field of the described ion source capillary inlet after the absolute value < energising of the voltage of electric field of the described ion source soleplate after the absolute value < energising of the voltage of electric field of the described ion source cylinder after power supply is accessed.
Thus, a multistage focusing electric field can be formed in ionization cavity, thus charged ion is focused on importing ion source capillary inlet.
The aspect that the present invention adds and advantage will part provide in the following description, and part will become obvious from the following description, or be recognized by practice of the present invention.
Accompanying drawing explanation
The present invention above-mentioned and/or additional aspect and advantage will become obvious and easy understand from the following description of the accompanying drawings of embodiments, wherein:
Fig. 1 is the structural representation for the ionogenic controllable high-voltage DC power supply of ESI according to the embodiment of the present invention;
Fig. 2 is the circuit diagram of Fig. 1 breaker in middle module;
Fig. 3 is the structural representation of boost module both sides in Fig. 1;
Fig. 4 is the circuit diagram of filtration module in Fig. 1;
Fig. 5 is the circuit diagram of polarity adjustment module;
Fig. 6 is according to the ionogenic structural representation of the ESI of the embodiment of the present invention.
Embodiment
Be described below in detail embodiments of the invention, the example of described embodiment is shown in the drawings, and wherein same or similar label represents same or similar element or has element that is identical or similar functions from start to finish.Being exemplary below by the embodiment be described with reference to the drawings, only for explaining the present invention, and can not limitation of the present invention being interpreted as.
Disclosing hereafter provides many different embodiments or example is used for realizing different structure of the present invention.Of the present invention open in order to simplify, hereinafter the parts of specific examples and setting are described.Certainly, they are only example, and object does not lie in restriction the present invention.In addition, the present invention can in different example repeat reference numerals and/or letter.This repetition is to simplify and clearly object, itself does not indicate the relation between discussed various embodiment and/or setting.In addition, the various specific technique that the invention provides and the example of material, but those of ordinary skill in the art can recognize the property of can be applicable to of other techniques and/or the use of other materials.In addition, fisrt feature described below second feature it " on " structure can comprise the embodiment that the first and second features are formed as directly contact, also can comprise other feature and be formed in embodiment between the first and second features, such first and second features may not be direct contacts.
In describing the invention, it will be appreciated that, term " longitudinal direction ", " transverse direction ", " on ", D score, "front", "rear", "left", "right", " vertically ", " level ", " top ", " end " " interior ", the orientation of the instruction such as " outward " or position relationship be based on orientation shown in the drawings or position relationship, only the present invention for convenience of description and simplified characterization, instead of indicate or imply that the device of indication or element must have specific orientation, with specific azimuth configuration and operation, therefore can not be interpreted as limitation of the present invention.
In describing the invention, it should be noted that, unless otherwise prescribed and limit, term " installation ", " being connected ", " connection " should be interpreted broadly, such as, can be mechanical connection or electrical connection, also can be the connection of two element internals, can be directly be connected, also indirectly can be connected by intermediary, for the ordinary skill in the art, the concrete meaning of above-mentioned term can be understood as the case may be.
Below with reference to Fig. 1 to Fig. 5 describe according to the embodiment of the present invention for the ionogenic controllable high-voltage DC power supply 100 of ESI.
As shown in Figure 1, what the embodiment of the present invention provided comprises for the ionogenic controllable high-voltage DC power supply 100 of ESI: oscillation module 1, switch module 2, boost module 3, voltage doubling rectifier module 4, filtration module 5 and output module 6, wherein, switch module 2 is connected with oscillation module 1, boost module 3 is connected with switch module 2, voltage doubling rectifier module 4 is connected with filtration module 5, and output module 6 is connected with filtration module 5.
Oscillation module 1 can generate switching signal by self-oscillation.As shown in Figure 2, oscillation module 1 comprises multivibrator and d type flip flop, and wherein multivibrator is cmos schmitt trigger, and cycle of oscillation is T,
Wherein, R is resistance, and C is electric capacity, and VDD is the supply voltage of Schmidt trigger, VT
+for the positive threshold voltage of Schmidt trigger, VT
-for the negative threshold voltage of Schmidt trigger.
With certain frequency alternate conduction under the control of the switching signal that switch module 2 exports at oscillation module 1, thus export initial alternating voltage.In one embodiment of the invention, switch module 2 can be field effect transistor, by controlling the alternate conduction of field effect transistor to export initial alternating voltage.
As shown in Figure 3, switch module 2 comprises the first field effect transistor 2a and the second field effect transistor 2b.The output of oscillation module 1 is connected with the grid of the second field effect transistor 2b with the grid of the first field effect transistor 2a respectively.First field effect transistor 2a and the second field effect transistor 2b under the control of switching signal with certain frequency alternate conduction, then the drain electrode of the first field effect transistor 2a and the drain electrode of the second field effect transistor 2b export initial alternating voltage respectively, thus electric in the interchange input that the primary side coating-forming voltage of boost module 3 is adjustable.Adopt field effect transistor as switch, have the advantages that switching over speed is fast, highly sensitive.
The initial alternating voltage that primary side inputs boosts by boost module 3, obtains secondary alternating voltage.In one embodiment of the invention, boost module 3 can be high frequency transformer.The primary side of high frequency transformer has three taps, wherein two taps are connected with the drain electrode of the second field effect transistor 2b with the drain electrode of the first field effect transistor 2a respectively, a tap of the primary side of high frequency transformer is connected with the input of voltage doubling rectifier module 4, to export the secondary alternating voltage obtained after boosting to voltage doubling rectifier module 4.
By the primary side of high frequency transformer and the coil turn ratio relation of primary side, obtain the voltage of the primary side of high frequency transformer.If the coil turn of the primary side of high frequency transformer is N1, the voltage of primary side is U1, and the coil turn of primary side is N2, and the voltage of primary side is U2, then
U1/U2＝N1/N2
Wherein, N1/N2 < 1, namely the turn number N 1 of primary side is less than the turn number N 2 of primary side, then the voltage U 1 of corresponding primary side is less than the voltage U 2 of primary side, the i.e. voltage of the voltage primary of high voltage side of primary side, thus can realize, to the boosting of initial alternating voltage, obtaining secondary alternating voltage.
Voltage doubling rectifier module 4 boosts according to preset multiple to above-mentioned secondary alternating voltage, and the voltage after boosting is carried out rectification to export DC high voltage.
DC high voltage after voltage doubling rectifier module 4 rectification is inputed to filtration module 5, and filtration module carries out filtering to the direct voltage after rectification.Fig. 4 shows the circuit diagram of filtration module 5.As can be seen from Figure 4, filtration module 5 adopts RC network.Output module 6 exports filtered DC high voltage to external equipment, such as, export the ionogenic ion source cylinder of ESI, ion source soleplate or ion source capillary inlet to.
In order to realize the detection and control to the DC high voltage exported, the high-voltage dc voltage needing output module 6 to export and the output current of boost module 3 detect, and testing result is carried out FEEDBACK CONTROL, to control the high voltage direct current that output module 6 exports.
The high-voltage DC power supply 100 that the embodiment of the present invention provides comprises control module 7, Voltage Regulator Module 8, current detection module 10 and voltage detection module 11 further.Wherein, current detection module 10 is connected for a tap of the primary side with boost module 3, voltage detection module 11 is connected with the output of filtration module 5, control module 7 is connected with voltage detection module 11 with current detection module 10 respectively, the input of Voltage Regulator Module 8 is connected with the output of control module 7 with filtration module 5 respectively, and the output of Voltage Regulator Module 8 is connected with the centre tap of the primary side of boost module 3.
Current detection module 10 detects the output current of boost module 3, namely detects the output current of the primary side of high frequency transformer.The output current value of the boost module 3 detected is sent to control module 7 by current detection module 10.Voltage detection module 11 detects the high-voltage dc voltage that output module 6 exports, and the output high-voltage dc voltage value detected is fed back to control module 7.
The high-voltage dc voltage that the output module 6 that the output current value of the boost module 3 detected from current detection module 10 and voltage detection module 11 detect exports stores by control module 7.In order to realize, to the FEEDBACK CONTROL of the DC high-voltage exported, being preset with regulation voltage initial value in control module 7.Filtered DC voltage value and default regulation voltage initial value are sent to Voltage Regulator Module 8 by control module 7.
Filtered DC voltage value and default regulation voltage initial value are carried out application condition amplification by Voltage Regulator Module 8, thus obtain the pressure regulation voltage after adjustment.Voltage Regulator Module 8 exports the regulation voltage after adjustment the input of boost module 3 to.When boost module 3 adopts high frequency transformer, Voltage Regulator Module 8 exports the regulation voltage after adjustment the primary side of high frequency transformer to, thus realizes the adjustment to initial alternating voltage.
By the adjustment of the initial alternating voltage of the primary side to boost module 3, and then the adjustment to the high voltage direct current that output module 6 exports can be realized.
The high voltage direct current exported by output module 6 can be applied to the ionogenic ion source cylinder of ESI, ion source soleplate and ion source capillary inlet, thus applies High Voltage electric field to above-mentioned three parts.By the adjustment of high voltage direct current exported output module 6, the optimizing regulation of the High Voltage electric field to ion source cylinder, ion source soleplate and ion source capillary inlet place can be realized.
In one embodiment of the invention, polarity adjustment module 9 is comprised further for the ionogenic high-voltage DC power supply 100 of ESI, the input of polarity adjustment module 9 is connected with the output of control module 7, and the output of polarity adjustment module 9 is connected with the input of current detection module 10, the input of Voltage Regulator Module 8, the input of voltage doubling rectifier module 4 respectively.
As shown in Figure 5, polarity adjustment module 9 is made up of d type flip flop and XOR gate.Wherein, d type flip flop is in triggering work pattern for a long time.The input signal of d type flip flop is polarity control signal Polarity, and high level is positive polarity, and low level is negative polarity.Two signals that d type flip flop output level is contrary, be respectively BUF-POL and BUF-POL.Contrary two signals of the level of above-mentioned output are connected with the Voltage Regulator Module 8 of rear class, current detection module 10 with voltage doubling rectifier module 4.By the conversion of low and high level, the composition of amplifying circuit can be compared by switched voltage adjustment module 8 medial error, the circuit composition of switch current detection module 10, switch the circuit composition of voltage doubling rectifier module 4, thus export different polarity, realize the function that polarity regulates.
Specifically, the electric current that the polarity of the charged ion that control module 7 ionizes out according to ESI and current detection module 10 and voltage detection module 9 detect and voltage, judge whether to need to carry out polarity adjustment to high voltage electric field.When judging to need to carry out polarity adjustment to high voltage electric field, then control polarity adjustment module 9 and carry out polarity adjustment.Specifically, polarity adjustment module 9 is respectively to Voltage Regulator Module 8, current detection module 10 and voltage doubling rectifier module 4 output polarity conditioning signal.Voltage Regulator Module 8, current detection module 10 and voltage doubling rectifier module 4 regulate corresponding magnitude of voltage and current value separately according to polarity conditioning signal, thus realize the control of the polarity of the high voltage electric field to the high voltage direct current electric forming exported, thus the charged ion of opposed polarity can be adapted to.
Due in the generative process of high voltage direct current, some functional modules are had to there will be fault in the course of the work, or the voltage of current output or current value and objective result exist relatively large deviation, in order to the accuracy of Output rusults, need that shutoff is carried out to high-voltage DC power supply 100 and control.
In one embodiment of the invention, comprising further for the ionogenic high-voltage DC power supply 100 of ESI that the embodiment of the present invention provides turns off control module 12.The input turning off control module 12 is connected with control module 7, and the output turning off control module 12 is connected with Voltage Regulator Module 8 with oscillation module 7 respectively.
The operating state of current high-voltage DC power supply 100 is detected by control module 7, according to the operating state of current high-voltage DC power supply 100, when detecting the partial function pattern needed in shutoff high-voltage DC power supply 100, then send to shutoff control module 12 and turn off control signal accordingly, turn off corresponding functional module by shutoff control module 12 according to the corresponding control signal that turns off.In one embodiment of the invention, control module 7 can to turn off that control module 12 sends in following multiple shutoff control signal one or more: switching signal turns off control signal, regulation voltage input turns off control signal and error gain amplifier turns off control signal.
Specifically, when control module 7 sends switching frequency shutoff control signal to shutoff control module 12, then shutoff control module 12 turns off the switching signal that oscillation module 1 provides to switch module 2.Because switch module 2 does not receive switching signal, thus can not control to export initial alternating voltage, and then follow-up functional module can not perform an action, without the output of high voltage direct current.
When control module 7 sends regulation voltage input shutoff control signal to shutoff control module 12, then shutoff control module 12 turns off control module 7 and inputs to Voltage Regulator Module 8 initial adjustment voltage, thus make Voltage Regulator Module 8 not receive initial adjustment voltage, can not voltage-regulation be performed.
When control module 7 sends error gain amplifier shutoff control signal to shutoff control module 12, then turn off control module 12 not to output module 6 export high voltage direct current and initial adjustment voltage carry out application condition amplification, thus initial adjustment voltage is inputed to the primary side of boost module 3, regulate with the high voltage direct current exported output module 6.
According to the embodiment of the present invention for the ionogenic high-voltage DC power supply of ESI, can to the high voltage of ESI ion source stable output and highfield, to make to form High Voltage electric field in the ionogenic ionization chamber of ESI.Further, the High Voltage electric field of above-mentioned formation can regulate.The high voltage direct current detecting output for the ionogenic high-voltage DC power supply of ESI in real time of the embodiment of the present invention, and feedback adjusting is carried out to above-mentioned high voltage direct current, realize the controllable management to the high voltage direct current exported.
Below with reference to Fig. 6, the ESI ion source 1000 according to the embodiment of the present invention is described.
As shown in Figure 6, the ESI ion source 1000 that the embodiment of the present invention provides comprises DC power supply group, ion source cylinder 200, ion source soleplate 300, ion source capillary 400, ESI nozzle needle 500, atomization gas sleeve pipe 600, dry gas heater 700 and dry gas sleeve pipe 800.
DC power supply group comprises the first controllable direct current power supply, the second controllable direct current power supply and the 3rd controllable direct current power supply, and wherein, the first controllable direct current power supply is connected with ion source cylinder 200, applies High Voltage electric field to ion source cylinder 200.Second controllable direct current power supply is connected with ion source soleplate 300, applies High Voltage electric field to ion source soleplate 300.3rd controllable direct current power supply is connected with ion source capillary 400, applies High Voltage electric field to ion source capillary 400.
In one embodiment of the invention, the first controllable direct current power supply, the second controllable direct current power supply and the 3rd controllable direct current power supply high-voltage DC power supply 100 that can provide for first aspect present invention embodiment.
Under the effect of the High Voltage electric field provided at the first controllable direct current power supply, the second controllable direct current power supply and the 3rd controllable direct current power supply, ion source cylinder 200, ion source soleplate 300 and ion source capillary 400 form a multistage focusing electric field jointly.
In one embodiment of the invention, the absolute value < that the absolute value < accessing the voltage of electric field of the ion source cylinder 200 after the first controllable direct current power supply accesses the voltage of electric field of the ion source soleplate 300 after the second controllable direct current power supply accesses the absolute value of the voltage of electric field of ion source capillary 400 entrance after the 3rd controllable direct current power supply.
Testing sample is entered in the ionization cavity that ion source cylinder 200 and ion source soleplate 300 surround by ESI nozzle needle 500.Be provided with atomization gas casing pipe sleeve 600 in the outer cover of ESI nozzle needle 500, atomization gas is passed in ionization cavity by atomization gas casing pipe sleeve 600.Testing sample High Voltage electric field and atomization gas blow band effect under form charged microlayer model.In an example of the present invention, atomization gas can be nitrogen.
Dry gas heater 700 is had, for heating dry gas in the outer setting of ion source cylinder 200.Dry gas is connected with dry gas sleeve pipe 800 further.Dry gas sleeve pipe 800 is arranged on the outside of ion source capillary 400, and is connected with ionization cavity.Dry gas after heating is passed in ionization cavity by dry gas sleeve pipe 800, utilizes dry gas to carry out drying to charged microlayer model, thus obtains charged ion.
Utilize ion source cylinder 200, ion source soleplate 300 and ion source capillary 400 jointly to form a multistage focusing electric field and charged ion is imported to ion source capillary inlet 400 efficiently.
The output DC high-voltage of the first controllable direct current power supply, the second controllable direct current power supply and the 3rd controllable direct current power supply can regulate.According to the degree of ionization of testing sample, the output high direct voltage of the first controllable direct current power supply, the second controllable direct current power supply and the 3rd controllable direct current power supply can be regulated, and then the optimizing regulation realized the electric field in ionization chamber, improve the efficiency of transmission of its ionizing efficiency and generation ion significantly.
According to the ESI ion source of the embodiment of the present invention, be applicable to provide high voltage and highfield to electric spray ion source battery lead plate, by the optimizing regulation to ion source internal electric field, the ionizing efficiency to testing sample and the efficiency of transmission producing ion can be improved significantly, help the sensitivity improving instrument, and ESI ion source can simply be expanded as ESI/APCI mixing source.
In the description of this specification, specific features, structure, material or feature that the description of reference term " embodiment ", " some embodiments ", " example ", " concrete example " or " some examples " etc. means to describe in conjunction with this embodiment or example are contained at least one embodiment of the present invention or example.In this manual, identical embodiment or example are not necessarily referred to the schematic representation of above-mentioned term.And the specific features of description, structure, material or feature can combine in an appropriate manner in any one or more embodiment or example.
Although illustrate and describe embodiments of the invention, for the ordinary skill in the art, be appreciated that and can carry out multiple change, amendment, replacement and modification to these embodiments without departing from the principles and spirit of the present invention, scope of the present invention is by claims and equivalency thereof.
Claims (8)
1., for the ionogenic high-voltage DC power supply of ESI, it is characterized in that, comprising:
Oscillation module, described oscillation module is used for carrying out self-oscillation to generate switching signal;
Switch module, described switch module is connected with described oscillation module, for alternate conduction under the control of described switching signal to export initial alternating voltage, wherein, described switch module comprises the first field effect transistor and the second field effect transistor, wherein, the output of described oscillation module is connected with the grid of described first field effect transistor and the grid of described second field effect transistor respectively, and the drain electrode of described first field effect transistor and the drain electrode of described second field effect transistor export initial alternating voltage respectively;
Boost module, described boost module is connected with described switch module, for described initial alternating voltage is boosted, obtain secondary alternating voltage, wherein, the input of described boost module is connected with the drain electrode of described second field effect transistor with the drain electrode of described first field effect transistor respectively, for described initial AC power is boosted, obtain secondary alternating voltage, described boost module is high frequency transformer, two taps of the primary side of described high frequency transformer are connected with the drain electrode of described second field effect transistor with the drain electrode of described first field effect transistor respectively, a tap of the primary side of described high frequency transformer is connected with voltage doubling rectifier module,
Current detection module, described current detection module is connected with a tap of the primary side of described boost module, for detecting the output current of described boost module;
Voltage doubling rectifier module, described voltage doubling rectifier module is connected with described boost module, for boosting according to preset multiple to described secondary alternating voltage, and the voltage after boosting is carried out rectification with output dc voltage;
Filtration module, described filtration module is connected with described voltage doubling rectifier module, for described direct voltage is carried out filtering;
Voltage detection module, described voltage detection module is connected with the output of described filtration module, for the direct voltage after detection filter;
Control module, described control module is connected with described voltage detection module with described current detection module respectively, for obtaining output current that described current detection module detects and the filtered direct voltage that described voltage detection module detects, in described control module, be preset with regulation voltage initial value;
Voltage Regulator Module, the input of described Voltage Regulator Module is connected with the output of described control module with described filtration module respectively, the output of described Voltage Regulator Module is connected with the centre tap of the primary side of described boost module, for amplifying obtains the regulation voltage after adjusting by carrying out application condition from the described filtered direct voltage of described control module and described regulation voltage initial value, and the primary side regulation voltage after described adjustment being exported to described high frequency transformer is to regulate described initial alternating voltage;
Output module, described output module is connected with described filtration module, for exporting described filtered direct voltage.
2. high-voltage DC power supply as claimed in claim 1, it is characterized in that, described oscillation module comprises multivibrator and d type flip flop.
3. high-voltage DC power supply as claimed in claim 2, it is characterized in that, described multivibrator comprises cmos schmitt trigger.
4. high-voltage DC power supply as claimed in claim 1, it is characterized in that, described filtration module is RC filter network.
5. high-voltage DC power supply as claimed in claim 1, is characterized in that, comprise further:
Polarity adjustment module, the input of described polarity adjustment module is connected with the output of described control module, the output of described polarity adjustment module is connected with the input of the input of described current detection module, described Voltage Regulator Module, the input of described voltage doubling rectifier module respectively, for two signals that output level is contrary, carry out low and high level switching by two signals contrary to described level and regulate with the polarity of the output signal to described Voltage Regulator Module, described current detection module and described voltage doubling rectifier module.
6. high-voltage DC power supply as claimed in claim 1, it is characterized in that, comprise further: turn off control module, the input of described shutoff control module is connected with described control module, the output of described shutoff control module is connected with described Voltage Regulator Module with described oscillation module respectively, turn off under the control of shutoff control signal that exports in described control module the switching signal that described switch module inputs to described boost module, and described Voltage Regulator Module inputs to the regulation voltage of described boost module.
7. an ESI ion source, is characterized in that, comprising:
DC power supply group, described DC power supply group comprises the first controllable high-voltage DC power supply, the second controllable high-voltage DC power supply, the 3rd controllable high-voltage DC power supply, wherein, described first controllable high-voltage DC power supply, described second controllable high-voltage DC power supply and described 3rd controllable high-voltage DC power supply are the high-voltage DC power supply according to any one of claim 1-6;
Ion source cylinder, described ion source cylinder is connected with described first controllable high-voltage DC power supply, and described first controllable high-voltage DC power supply provides electric field to described ion source cylinder;
Ion source soleplate, described ion source soleplate is connected with described second controllable high-voltage DC power supply, and described second controllable high-voltage DC power supply provides electric field to described ion source soleplate;
ESI nozzle needle, described ESI nozzle needle is used for testing sample to be delivered in the cavity that described ion source cylinder and described ion source soleplate surround;
Atomization gas sleeve pipe, described atomization gas casing pipe sleeve is located at the outside of described ESI nozzle needle, pass into atomization gas in the ionization cavity that surrounds to described ion source cylinder and described ion source soleplate, the electric field that the described ion source cylinder of described testing sample after access power supply and described ion source soleplate are formed and described atomization gas blow band effect under form charged microlayer model;
Dry gas heater, passes into dry gas in described dry gas heater, and described dry gas heater is used for heating described dry gas;
Dry gas sleeve pipe, described dry gas casing pipe sleeve is connected with described dry gas heater, be located at the outside of described ion source capillary and be connected with described ionization cavity, for the dry gas after described heating being passed into described ionization cavity to carry out drying to charged microlayer model, obtain charged ion;
Ion source capillary, described ion source capillary is connected with described 3rd controllable high-voltage DC power supply, described ion source cylinder, described ion source soleplate and described ion source capillary after access power supply form focusing electric field, and described dried charged ion focuses on and is directed into described ion source capillary inlet under the effect of described focusing electric field.
8. ESI ion source as claimed in claim 7, is characterized in that,
The absolute value of the voltage of electric field of the described ion source capillary inlet after the absolute value < energising of the voltage of electric field of the described ion source soleplate after the absolute value < energising of the voltage of electric field of the described ion source cylinder after access power supply.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201110293776.3A CN103035471B (en) | 2011-09-29 | 2011-09-29 | ESI ion source, for its controllable high-voltage DC power supply |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201110293776.3A CN103035471B (en) | 2011-09-29 | 2011-09-29 | ESI ion source, for its controllable high-voltage DC power supply |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103035471A CN103035471A (en) | 2013-04-10 |
| CN103035471B true CN103035471B (en) | 2015-07-29 |
Family
ID=48022259
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201110293776.3A Active CN103035471B (en) | 2011-09-29 | 2011-09-29 | ESI ion source, for its controllable high-voltage DC power supply |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN103035471B (en) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104201084B (en) * | 2014-06-12 | 2017-02-01 | 浙江好创生物技术有限公司 | Closed type molecular adduct isotope ion generator |
| CN104037047B (en) * | 2014-06-12 | 2016-04-20 | 浙江好创生物技术有限公司 | A kind of method preparing molecule adduction isotope ion |
| CN104166419B (en) * | 2014-08-29 | 2017-01-18 | 江苏天瑞仪器股份有限公司 | Controllable high-voltage direct current power supply |
| CN104409311B (en) * | 2014-11-18 | 2016-08-17 | 钢研纳克检测技术有限公司 | A kind of for mass spectrometric lens current supply |
| CN104967311A (en) * | 2015-06-09 | 2015-10-07 | 广州禾信分析仪器有限公司 | Direct-current high-voltage power supply used for mass spectrometer |
| CN115763213B (en) * | 2022-11-22 | 2023-11-14 | 广东智普生命科技有限公司 | Micro-current detection system capable of being charged online for electrospray source |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2002279930A (en) * | 2001-03-22 | 2002-09-27 | Jeol Ltd | Ion source power supply for mass spectrometer |
| CN101373695A (en) * | 2007-08-23 | 2009-02-25 | 岛津分析技术研发（上海）有限公司 | Method and apparatus for observing and controlling digital ion trap |
| WO2009041774A2 (en) * | 2007-09-28 | 2009-04-02 | Hyundai Calibration & Certification Technologies Co., Ltd. | Electrospray vaporizer |
| CN101599409A (en) * | 2009-07-23 | 2009-12-09 | 上海华质生物技术有限公司 | Electric spray ion source |
| CN102142352A (en) * | 2011-02-12 | 2011-08-03 | 浙江好创生物技术有限公司 | Electro-spray ion generator |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5122670A (en) * | 1991-05-17 | 1992-06-16 | Finnigan Corporation | Multilayer flow electrospray ion source using improved sheath liquid |
| JP4167593B2 (en) * | 2002-01-31 | 2008-10-15 | 株式会社日立ハイテクノロジーズ | Electrospray ionization mass spectrometer and method thereof |
| EP1931020B1 (en) * | 2005-09-08 | 2015-11-11 | Shimadzu Corporation | High-voltage power supply and mass spectrometer using the same |
| GB0524979D0 (en) * | 2005-12-07 | 2006-01-18 | Queen Mary & Westfield College | An electrospray device and a method of electrospraying |
-
2011
- 2011-09-29 CN CN201110293776.3A patent/CN103035471B/en active Active
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2002279930A (en) * | 2001-03-22 | 2002-09-27 | Jeol Ltd | Ion source power supply for mass spectrometer |
| CN101373695A (en) * | 2007-08-23 | 2009-02-25 | 岛津分析技术研发（上海）有限公司 | Method and apparatus for observing and controlling digital ion trap |
| WO2009041774A2 (en) * | 2007-09-28 | 2009-04-02 | Hyundai Calibration & Certification Technologies Co., Ltd. | Electrospray vaporizer |
| CN101599409A (en) * | 2009-07-23 | 2009-12-09 | 上海华质生物技术有限公司 | Electric spray ion source |
| CN102142352A (en) * | 2011-02-12 | 2011-08-03 | 浙江好创生物技术有限公司 | Electro-spray ion generator |
Also Published As
| Publication number | Publication date |
|---|---|
| CN103035471A (en) | 2013-04-10 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN103035471B (en) | ESI ion source, for its controllable high-voltage DC power supply | |
| CN107579662B (en) | Double-plasma ion source discharge power supply | |
| CN101688848A (en) | Methods and apparatus of ion mobility spectrometer | |
| CN102971827A (en) | Triple switch topology for delivering ultrafast pulser polarity switching for mass spectrometry | |
| WO2007029327A1 (en) | High-voltage power supply and mass spectrometer using the same | |
| CN102903596B (en) | A kind of ion source temperature control heating device | |
| CN107852808A (en) | Plasma generator and the method for adjusting ion ratio | |
| WO2017194333A1 (en) | Apparatus and method for detecting ions | |
| CN101208565A (en) | Heat generator | |
| CN104124131A (en) | Mass spectrum ion source and mass spectrometer | |
| CN105409106B (en) | High-voltage power supply device and the quality analysis apparatus using the device | |
| CN219552578U (en) | Switch cabinet fault monitoring circuit | |
| JP2019211440A (en) | Ion mobility analyzer | |
| CN206962710U (en) | A kind of double-plasma ion source discharge power supply | |
| CN102313776A (en) | Ion mobility spectrometry | |
| CN103903955A (en) | Ion enrichment and lead-in device and method for atmospheric ion source time-of-flight mass spectrometer | |
| CN106711010A (en) | Quadrupole guide rod radio frequency power supply circuit of mass spectrometer | |
| US8927943B2 (en) | Device for obtaining the ion source of a mass spectrometer using an ultraviolet diode and a CEM | |
| CN105097413B (en) | Novel ion source and ionization method | |
| CN112509904A (en) | Switchable digital ion trap mass spectrum radio frequency power supply system and control method thereof | |
| CN203787386U (en) | Ion enrichment introducing apparatus of atmospheric pressure ion source time-of-flight mass spectrometer | |
| CN104538273A (en) | Power supply device of high-voltage cold cathode gas discharging electronic gun and control method of power supply device | |
| CN211148673U (en) | High-field asymmetric waveform ion mobility device for protein detection | |
| Zhao et al. | Modification of reflectron time-of-flight mass spectrometer for photodissociation of mass-selected cluster ions | |
| CN204013238U (en) | Controllable high-voltage AC power |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant |