CN103028136A - Hydrocolloid dressing and preparation method thereof - Google Patents
Hydrocolloid dressing and preparation method thereof Download PDFInfo
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- CN103028136A CN103028136A CN2012105460074A CN201210546007A CN103028136A CN 103028136 A CN103028136 A CN 103028136A CN 2012105460074 A CN2012105460074 A CN 2012105460074A CN 201210546007 A CN201210546007 A CN 201210546007A CN 103028136 A CN103028136 A CN 103028136A
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- hydrocolloid
- polyisobutylene
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- 239000000416 hydrocolloid Substances 0.000 title claims abstract description 93
- 238000002360 preparation method Methods 0.000 title claims abstract description 15
- 229920002367 Polyisobutene Polymers 0.000 claims abstract description 46
- 150000001875 compounds Chemical class 0.000 claims abstract description 45
- 230000007935 neutral effect Effects 0.000 claims abstract description 17
- 229920001661 Chitosan Polymers 0.000 claims abstract description 13
- 150000003839 salts Chemical class 0.000 claims abstract description 10
- 239000001814 pectin Substances 0.000 claims abstract description 9
- 235000010987 pectin Nutrition 0.000 claims abstract description 9
- 229920001277 pectin Polymers 0.000 claims abstract description 9
- 108010010803 Gelatin Proteins 0.000 claims abstract description 8
- 239000008273 gelatin Substances 0.000 claims abstract description 8
- 229920000159 gelatin Polymers 0.000 claims abstract description 8
- 235000019322 gelatine Nutrition 0.000 claims abstract description 8
- 235000011852 gelatine desserts Nutrition 0.000 claims abstract description 8
- 229920002907 Guar gum Polymers 0.000 claims abstract description 6
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims abstract description 6
- 239000001768 carboxy methyl cellulose Substances 0.000 claims abstract description 6
- 235000010417 guar gum Nutrition 0.000 claims abstract description 6
- 239000000665 guar gum Substances 0.000 claims abstract description 6
- 229960002154 guar gum Drugs 0.000 claims abstract description 6
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 claims abstract description 6
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 claims abstract description 6
- 235000010418 carrageenan Nutrition 0.000 claims abstract description 5
- 229920001525 carrageenan Polymers 0.000 claims abstract description 5
- 229920000642 polymer Polymers 0.000 claims abstract description 5
- 235000010413 sodium alginate Nutrition 0.000 claims abstract description 5
- 239000000661 sodium alginate Substances 0.000 claims abstract description 5
- 229940005550 sodium alginate Drugs 0.000 claims abstract description 5
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 claims abstract description 4
- 229920001503 Glucan Polymers 0.000 claims abstract description 4
- 229920000161 Locust bean gum Polymers 0.000 claims abstract description 4
- 235000010420 locust bean gum Nutrition 0.000 claims abstract description 4
- 239000000711 locust bean gum Substances 0.000 claims abstract description 4
- 235000010493 xanthan gum Nutrition 0.000 claims abstract description 4
- 239000000230 xanthan gum Substances 0.000 claims abstract description 4
- 229920001285 xanthan gum Polymers 0.000 claims abstract description 4
- 229940082509 xanthan gum Drugs 0.000 claims abstract description 4
- 239000000203 mixture Substances 0.000 claims description 39
- 239000000843 powder Substances 0.000 claims description 27
- 238000001125 extrusion Methods 0.000 claims description 9
- 230000008676 import Effects 0.000 claims description 9
- 238000010030 laminating Methods 0.000 claims description 9
- 238000000465 moulding Methods 0.000 claims description 9
- 238000003756 stirring Methods 0.000 claims description 9
- TWNIBLMWSKIRAT-VFUOTHLCSA-N levoglucosan Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@H]2CO[C@@H]1O2 TWNIBLMWSKIRAT-VFUOTHLCSA-N 0.000 claims description 3
- KQCBYLOBOGMDSY-OMCTUWBCSA-N n-[(2r,3r,4r,5r,6r)-5-[(2s,3r,4r,5r,6r)-3-acetamido-5-[(2s,3r,4r,5s,6r)-3-acetamido-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-4-hydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-2,4-dihydroxy-6-(hydroxymethyl)oxan-3-yl]acetamide;2-hydroxybutanedioic acid Chemical compound OC(=O)C(O)CC(O)=O.O[C@@H]1[C@@H](NC(=O)C)[C@H](O)O[C@H](CO)[C@@H]1O[C@H]1[C@H](NC(C)=O)[C@@H](O)[C@@H](O[C@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](CO)O1 KQCBYLOBOGMDSY-OMCTUWBCSA-N 0.000 claims description 3
- 239000004745 nonwoven fabric Substances 0.000 claims description 3
- 229920006264 polyurethane film Polymers 0.000 claims description 3
- 206010052428 Wound Diseases 0.000 abstract description 16
- 208000027418 Wounds and injury Diseases 0.000 abstract description 16
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract description 9
- 230000035876 healing Effects 0.000 abstract description 3
- 230000000694 effects Effects 0.000 abstract description 2
- MZVQCMJNVPIDEA-UHFFFAOYSA-N [CH2]CN(CC)CC Chemical group [CH2]CN(CC)CC MZVQCMJNVPIDEA-UHFFFAOYSA-N 0.000 abstract 1
- 230000029663 wound healing Effects 0.000 abstract 1
- 238000010521 absorption reaction Methods 0.000 description 7
- -1 compounds chitosan malate Chemical class 0.000 description 4
- 150000002306 glutamic acid derivatives Chemical class 0.000 description 3
- 238000005303 weighing Methods 0.000 description 3
- 230000006378 damage Effects 0.000 description 2
- 235000015110 jellies Nutrition 0.000 description 2
- 239000008274 jelly Substances 0.000 description 2
- 239000008363 phosphate buffer Substances 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 1
- 229920002307 Dextran Polymers 0.000 description 1
- 206010016717 Fistula Diseases 0.000 description 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
- 208000002847 Surgical Wound Diseases 0.000 description 1
- 206010053692 Wound complication Diseases 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000004132 cross linking Methods 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 239000005038 ethylene vinyl acetate Substances 0.000 description 1
- 210000000416 exudates and transudate Anatomy 0.000 description 1
- 230000003890 fistula Effects 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 230000001473 noxious effect Effects 0.000 description 1
- 229920001200 poly(ethylene-vinyl acetate) Polymers 0.000 description 1
- 229910052814 silicon oxide Inorganic materials 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
Landscapes
- Materials For Medical Uses (AREA)
Abstract
The invention provides hydrocolloid dressing and a preparation method thereof. The hydrocolloid dressing at least comprises backlining, hydrocolloid and a stripping layer, wherein the hydrocolloid is arranged on the backlining; the stripping layer is arranged on the hydrocolloid; the hydrocolloid comprises the following components in percentage by mass: 30 to 50 percent of polyisobutene, 15 to 25 percent of polycationic compound, 15 to 20 percent of polyanionic compound and 10 to 35 percent of neutral polymer; the polycationic compound consists of at least one of chitosan salt and diethyl amino ethyl glucan; the polyanionic compound consists of at least one of pectin, sodium carboxymethylcellulose, sodium alginate, carrageenin and xanthan gum; and the neutral polymer consists of at least one of gelatin, locust bean gum and guar gum. The hydrocolloid dressing can form a wet healing environment at the wound position, has a good wound healing effect and excellent water absorbency and stability, is suitable for high-leachability wounds, has excellent softness and autohension, and is convenient to use.
Description
Technical field
The present invention relates to a kind of dressing and preparation method thereof, particularly a kind of bearing hydrocolloid dressing and preparation method thereof.
Background technology
Bearing hydrocolloid dressing should have following features: (1) can absorb a large amount of transudates and noxious substance, also can keep certain form and intensity when moistening; (2) can keep the enough humidity of wound, reasonable resistance bacterium property and bacteriostasis are arranged; (3) more change dressings to the wound not damaged; (4) excellent storage stability has degradability, and the garbage of bearing hydrocolloid dressing does not produce pollution to environment.Bearing hydrocolloid dressing since can create moist healing environment with and the character of semipermeable membrane, particularly be widely used in the dressing at medical supplies.Compare with traditional dressing, the dressing that utilizes hydrocolloid to make has following advantage: heal comparatively fast, be convenient to medical personnel's operation, antibacterial can not see through, alleviates wound pain, reduce dressing change frequency.
Many traditional hydrocolloids are arranged in the market, and structure is by partial destruction after such hydrocolloid suction, and mechanical property significantly descends, very easily fracture, and humid stability is very poor.But in the clinical practice, the liquid seepage discharge of some common wounds is larger, fistula of operative incision surgical wound for example, but using such hydrocolloid causes splitting of dressing easily, and wound exposes, and has increased patient's misery, is unfavorable for that also medical personnel operate.Therefore, for such a large amount of exudative type wounds, the bearing hydrocolloid dressing that needs the medical worker constantly more to renew.Traditional bearing hydrocolloid dressing is in wound closure in addition, can form one deck jelly at wound, when medical worker's change dressings more, need to clear up the residual jelly of dressing, and this can cause further destruction to wound, cause wound fluid to increase, and increased medical worker's workload.
Some research work have been devoted to improve the humid stability of bearing hydrocolloid dressing at present.For example, usually improve the mechanical property of hydrocolloid and the stability after the suction by in hydrocolloid, sneaking into silicon oxide or ethylene-vinyl acetate copolymer or cross-linking dextran or cross filament.But these methods all are the water absorbing capacities by the reduction hydrocolloid, thereby improve its stability.Therefore, this class bearing hydrocolloid dressing and be not suitable for some high exudative wounds.
Summary of the invention
In order to solve the deficiencies in the prior art, it is good to the invention provides a kind of water absorption and humid stability, is fit to bearing hydrocolloid dressing of high exudative wound and preparation method thereof.
The technical solution adopted for the present invention to solve the technical problems is:
A kind of bearing hydrocolloid dressing, at least comprise backing, hydrocolloid and peel ply, hydrocolloid is arranged on the backing, peel ply is arranged on the hydrocolloid, the mass percent of each composition is in the described hydrocolloid: the shared mass fraction of polyisobutylene is 30% ~ 50%, polycationic compounds is 15% ~ 25%, and polyanionic compound is 15% ~ 20%, and neutral polymer is 10% ~ 35%; Polycationic compounds is by at least a composition the in chitosan salt and the diethyllaminoethyl glucosan, polyanionic compound is by at least a composition the in pectin, sodium carboxymethyl cellulose, sodium alginate, carrageenin and the xanthan gum, and neutral compound is by at least a composition the in gelatin, locust bean gum and the guar gum.
Preferred as such scheme, described polyisobutylene includes low-molecular-weight and high molecular weight polyisobutylene.
Described polycation is comprised of chitosan salt, and chitosan salt is the chitosan malate.
Described polyanionic compound is comprised of pectin.
Described backing is comprised of polyurethane film or non-woven fabrics.
A kind of preparation method of bearing hydrocolloid dressing as described above may further comprise the steps:
(1) preparation premixed solution: choose polyisobutylene by composition proportion, polyisobutylene includes low-molecular-weight and high molecular weight polyisobutylene, the ratio of mass fraction between the two is 4:1, low-molecular-weight and high molecular weight polyisobutylene are mixed and stirs, and obtains premixed solution;
(2) preparation premix powder: choose polycationic compounds, polyanionic compound and neutral compound by composition proportion, mix homogeneously also grinds, and obtains the premix powder;
(3) produce hydrocolloid: premix powder and premixed solution are stirred, and import the mold heated extrusion forming, obtain hydrocolloid, heating-up temperature adopts 150 ℃, and pressurization pressure is 13 ~ 14MPa;
(4) overlay film molding: adopt the step-by-step movement laminating machine to cover backing in the one side of hydrocolloid, another side covers upper peel ply, obtains bearing hydrocolloid dressing, and peel ply is release paper.
Preferred as such scheme, the molecular weight of described low-molecular-weight polyisobutylene is 10000-12000, the polyisobutene molecular weight of high molecular is 80000-100000.
The present invention than the beneficial effect that prior art has is: bearing hydrocolloid dressing provided by the invention and preparation method thereof, than traditional bearing hydrocolloid dressing, can form in the wound moist healing environment, wound is played good effect better, and its water absorption and stable state are good, be applicable to some high exudative wounds, and bearing hydrocolloid dressing has good flexibility and autohension, easy to use.
The specific embodiment
The invention will be further described below in conjunction with embodiment.
A kind of bearing hydrocolloid dressing, at least comprise backing, hydrocolloid and peel ply, hydrocolloid is arranged on the backing, peel ply is arranged on the hydrocolloid, the mass percent of each composition is in the described hydrocolloid: the shared mass fraction of polyisobutylene is 30% ~ 50%, polycationic compounds is 15% ~ 25%, and polyanionic compound is 15% ~ 20%, and neutral polymer is 10% ~ 35%; Polycationic compounds is by at least a composition the in chitosan salt and the diethyllaminoethyl glucosan, polyanionic compound is by at least a composition the in pectin, sodium carboxymethyl cellulose, sodium alginate, carrageenin and the xanthan gum, and neutral compound is by at least a composition the in gelatin, locust bean gum and the guar gum.
Preferred as such scheme, described polyisobutylene includes low-molecular-weight and high molecular weight polyisobutylene.Described polycation is comprised of chitosan salt, and chitosan salt is the chitosan malate.Described polyanionic compound is comprised of pectin.Described backing is comprised of polyurethane film or non-woven fabrics.
A kind of preparation method of bearing hydrocolloid dressing, at first prepare premixed solution: choose polyisobutylene by composition proportion, polyisobutylene includes low-molecular-weight and high molecular weight polyisobutylene, the ratio of mass fraction between the two is 4:1, low-molecular-weight and high molecular weight polyisobutylene are mixed and stir, obtain premixed solution; Next prepares the premix powder: choose polycationic compounds, polyanionic compound and neutral compound by composition proportion, mix homogeneously also grinds, and obtains the premix powder; Then produce hydrocolloid: premix powder and premixed solution are stirred, and import the mold heated extrusion forming, obtain hydrocolloid, heating-up temperature adopts 150 ℃, and pressurization pressure is 13 ~ 14MPa; Last overlay film molding: adopt the step-by-step movement laminating machine to cover backing in the one side of hydrocolloid, another side covers upper peel ply, obtains bearing hydrocolloid dressing, and peel ply is release paper.
Preferred as such scheme, the molecular weight of described low-molecular-weight polyisobutylene is 10000-12000, the polyisobutene molecular weight of high molecular is 80000-100000.
In present embodiment 1, at first prepare premixed solution: choose low-molecular-weight polyisobutylene 3.2 ㎏ by composition proportion, high molecular weight polyisobutylene 0.8 ㎏ mixes low-molecular-weight and high molecular weight polyisobutylene and stirs, and obtains premixed solution; Next prepares the premix powder: choose polycationic compounds chitosan malate 2.0 ㎏, polyanionic compound pectin 2.0 ㎏ and neutral compound guar gum 2.0 ㎏ by composition proportion, mix homogeneously also grinds, and obtains the premix powder; Then produce hydrocolloid: premix powder and premixed solution are stirred, and import the mold heated extrusion forming, obtain hydrocolloid, heating-up temperature adopts 150 ℃, and pressurization pressure is 13.7MPa; Last overlay film molding: adopt the step-by-step movement laminating machine to cover backing in the one side of hydrocolloid, another side covers upper peel ply, obtains bearing hydrocolloid dressing A, and peel ply is release paper.
In present embodiment 2, at first prepare premixed solution: choose low-molecular-weight polyisobutylene 3.2 ㎏ by composition proportion, high molecular weight polyisobutylene 0.8 ㎏ mixes low-molecular-weight and high molecular weight polyisobutylene and stirs, and obtains premixed solution; Next prepares the premix powder: choose polycationic compounds chitosan malate 2.0 ㎏, polyanionic compound pectin 2.0 ㎏ and neutral compound gelatin 2.0 ㎏ by composition proportion, mix homogeneously also grinds, and obtains the premix powder; Then produce hydrocolloid: premix powder and premixed solution are stirred, and import the mold heated extrusion forming, obtain hydrocolloid, heating-up temperature adopts 150 ℃, and pressurization pressure is 13.7MPa; Last overlay film molding: adopt the step-by-step movement laminating machine to cover backing in the one side of hydrocolloid, another side covers upper peel ply, obtains bearing hydrocolloid dressing B, and peel ply is release paper.
In present embodiment 3, at first prepare premixed solution: choose low-molecular-weight polyisobutylene 3.2 ㎏ by composition proportion, high molecular weight polyisobutylene 0.8 ㎏ mixes low-molecular-weight and high molecular weight polyisobutylene and stirs, and obtains premixed solution; Next prepares the premix powder: choose polycationic compounds chitosan malate 2.0 ㎏, polyanionic compound sodium carboxymethyl cellulose 2.0 ㎏ and neutral compound gelatin 2.0 ㎏ by composition proportion, mix homogeneously also grinds, and obtains the premix powder; Then produce hydrocolloid: premix powder and premixed solution are stirred, and import the mold heated extrusion forming, obtain hydrocolloid, heating-up temperature adopts 150 ℃, and pressurization pressure is 13.7MPa; Last overlay film molding: adopt the step-by-step movement laminating machine to cover backing in the one side of hydrocolloid, another side covers upper peel ply, obtains bearing hydrocolloid dressing D, and peel ply is release paper.
In present embodiment 4, at first prepare premixed solution: choose low-molecular-weight polyisobutylene 3.2 ㎏ by composition proportion, high molecular weight polyisobutylene 0.8 ㎏ mixes low-molecular-weight and high molecular weight polyisobutylene and stirs, and obtains premixed solution; Next prepares the premix powder: choose polycationic compounds chitosan glutamate salt 2.0 ㎏, polyanionic compound sodium carboxymethyl cellulose 2.0 ㎏ and neutral compound gelatin 2.0 ㎏ by composition proportion, mix homogeneously also grinds, and obtains the premix powder; Then produce hydrocolloid: premix powder and premixed solution are stirred, and import the mold heated extrusion forming, obtain hydrocolloid, heating-up temperature adopts 150 ℃, and pressurization pressure is 13.7MPa; Last overlay film molding: adopt the step-by-step movement laminating machine to cover backing in the one side of hydrocolloid, another side covers upper peel ply, obtains bearing hydrocolloid dressing C, and peel ply is release paper.
In present embodiment 5, at first prepare premixed solution: choose low-molecular-weight polyisobutylene 3.2 ㎏ by composition proportion, high molecular weight polyisobutylene 0.8 ㎏ mixes low-molecular-weight and high molecular weight polyisobutylene and stirs, and obtains premixed solution; Next prepares the premix powder: choose polycationic compounds chitosan glutamate salt 2.0 ㎏, polyanionic compound sodium alginate 2.0 ㎏ and neutral compound gelatin 2.0 ㎏ by composition proportion, mix homogeneously also grinds, and obtains the premix powder; Then produce hydrocolloid: premix powder and premixed solution are stirred, and import the mold heated extrusion forming, obtain hydrocolloid, heating-up temperature adopts 150 ℃, and pressurization pressure is 13.7MPa; Last overlay film molding: adopt the step-by-step movement laminating machine to cover backing in the one side of hydrocolloid, another side covers upper peel ply, obtains bearing hydrocolloid dressing E, and peel ply is release paper..
In present embodiment 6, at first prepare premixed solution: choose low-molecular-weight polyisobutylene 3.2 ㎏ by composition proportion, high molecular weight polyisobutylene 0.8 ㎏ mixes low-molecular-weight and high molecular weight polyisobutylene and stirs, and obtains premixed solution; Next prepares the premix powder: choose polycationic compounds chitosan glutamate salt 2.0 ㎏, polyanionic compound carrageenin 2.0 ㎏ and neutral compound guar gum 2.0 ㎏ by composition proportion, mix homogeneously also grinds, and obtains the premix powder; Then produce hydrocolloid: premix powder and premixed solution are stirred, and import the mold heated extrusion forming, obtain hydrocolloid, heating-up temperature adopts 150 ℃, and pressurization pressure is 13.7MPa; Last overlay film molding: adopt the step-by-step movement laminating machine to cover backing in the one side of hydrocolloid, another side covers upper peel ply, obtains bearing hydrocolloid dressing F, and peel ply is release paper.
The humid stability of the hydrocolloid of the bearing hydrocolloid dressing A ~ F that makes for above-described embodiment 1 ~ 6 and water absorption are measured, and assay method is as follows:
Humid stability is measured: the hydrocolloid to be tested of choosing area and be 2.5 ㎝ *, 2.5 ㎝ is weighed, and institute weighs and is designated as W
1, the hydrocolloid to be tested of finishing weighing joins and is equipped with in the centrifuge tube of phosphate buffer that pH value is 7.4 40ml; Then centrifuge tube is rotated 18h with 50z/min, obtain sample.At last sample is weighed behind the dry 6h in the drying baker of 80 ℃ of constant temperature and constant humidity 10%, institute weighs and is designated as W
2
Humid stability is calculated as follows equation: humid stability=W
2/ W
1* 100.
Water absorption is measured: the hydrocolloid to be tested of choosing area and be 2.5 ㎝ *, 2.5 ㎝ is weighed, and institute weighs and is designated as W
3, the hydrocolloid to be tested of finishing weighing joins and is equipped with in the centrifuge tube of phosphate buffer that pH value is 7.4 40ml; Then centrifuge tube is left standstill 24h, obtain sample.With samples weighing, institute weighs and is designated as W at last
4
Water absorption is calculated as follows equation: water absorption=W
4/ W
3* 100.
The hydrocolloid humid stability of dressing A-F of the present invention and water absorption test result are as showing-1:
Table-1
Claims (7)
1. bearing hydrocolloid dressing, it is characterized in that: comprise at least backing, hydrocolloid and peel ply, hydrocolloid is arranged on the backing, peel ply is arranged on the hydrocolloid, the mass percent of each composition is in the described hydrocolloid: the shared mass fraction of polyisobutylene is 30% ~ 50%, polycationic compounds is 15% ~ 25%, and polyanionic compound is 15% ~ 20%, and neutral polymer is 10% ~ 35%; Polycationic compounds is by at least a composition the in chitosan salt and the diethyllaminoethyl glucosan, polyanionic compound is by at least a composition the in pectin, sodium carboxymethyl cellulose, sodium alginate, carrageenin and the xanthan gum, and neutral compound is by at least a composition the in gelatin, locust bean gum and the guar gum.
2. bearing hydrocolloid dressing according to claim 1, it is characterized in that: described polyisobutylene includes low-molecular-weight and high molecular weight polyisobutylene.
3. bearing hydrocolloid dressing according to claim 1, it is characterized in that: described polycation is comprised of chitosan salt, and chitosan salt is the chitosan malate.
4. bearing hydrocolloid dressing according to claim 1, it is characterized in that: described polyanionic compound is comprised of pectin.
5. bearing hydrocolloid dressing according to claim 1, it is characterized in that: described backing is comprised of polyurethane film or non-woven fabrics.
6. the preparation method of a bearing hydrocolloid dressing as claimed in claim 1 is characterized in that may further comprise the steps:
(1) preparation premixed solution: choose polyisobutylene by composition proportion, polyisobutylene includes low-molecular-weight and high molecular weight polyisobutylene, the ratio of mass fraction between the two is 4:1, low-molecular-weight and high molecular weight polyisobutylene are mixed and stirs, and obtains premixed solution;
(2) preparation premix powder: choose polycationic compounds, polyanionic compound and neutral compound by composition proportion, mix homogeneously also grinds, and obtains the premix powder;
(3) produce hydrocolloid: premix powder and premixed solution are stirred, and import the mold heated extrusion forming, obtain hydrocolloid, heating-up temperature adopts 150 ℃, and pressurization pressure is 13 ~ 14MPa;
(4) overlay film molding: adopt the step-by-step movement laminating machine to cover backing in the one side of hydrocolloid, another side covers upper peel ply, obtains bearing hydrocolloid dressing, and peel ply is release paper.
7. preparation method according to claim 6, it is characterized in that: the molecular weight of described low-molecular-weight polyisobutylene is 10000-12000, the polyisobutene molecular weight of high molecular is 80000-100000.
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| CN104784741A (en) * | 2015-04-23 | 2015-07-22 | 武汉市思泰利医疗器械发展有限公司 | Functional medical dressing containing chitosan and hydrocolloid |
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| CN109276743A (en) * | 2018-11-08 | 2019-01-29 | 广州润虹医药科技股份有限公司 | A kind of fast-acting nemostatic yarn and its preparation method and application promoting wound healing |
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| CN109276743B (en) * | 2018-11-08 | 2021-07-27 | 广州润虹医药科技股份有限公司 | Quick-acting hemostatic yarn for promoting wound healing and preparation method and application thereof |
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