CN103006512A - Hirudin anti-winkle face-softening conditioning cream and production process thereof - Google Patents
Hirudin anti-winkle face-softening conditioning cream and production process thereof Download PDFInfo
- Publication number
- CN103006512A CN103006512A CN2012105603788A CN201210560378A CN103006512A CN 103006512 A CN103006512 A CN 103006512A CN 2012105603788 A CN2012105603788 A CN 2012105603788A CN 201210560378 A CN201210560378 A CN 201210560378A CN 103006512 A CN103006512 A CN 103006512A
- Authority
- CN
- China
- Prior art keywords
- hirudin
- skin
- pot
- crease
- resistant
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Cosmetics (AREA)
Abstract
The invention belongs to the field of cosmetics and particularly relates to hirudin anti-winkle face-softening conditioning cream and a production process thereof. The conditioning cream is prepared by oil phase raw materials such as squalane, hexadecyl alcohol/hexadecyl glucoside, jojoba oil, glyceryl monostearate/PEG (polyethylene glycol)-100 stearate and dimethyl silicon oil, and water phase raw materials such as hirudin, oat polypeptide, oat beta-glucan, D panthenol, collagen polypeptide, a saffron crocus extracting solution and a ginseng extract. The production process comprises the steps of heating, sterilization, stirring, dissolving, emulsifying, homogenizing, cooling, discharging, sampling, detecting, filling, and packaging to obtain the conditioning cream. The conditioning cream can directly permeate into a corium layer of skin autonomously, can be easily absorbed by the skin, can solve the problems such as presenility of the skin and wrinkles of eyes caused by unsmooth blood circulation, is very good in wrinkle-removing effect, improves facial microcirculation, and has a function of improving the skin quality; as multiple moisture-keeping, skin-moisturizing and oxidation-resisting raw materials are added, the conditioning cream has very good whitening and nourishing effects; and the production process is simple and easy to operate.
Description
Technical field
The invention belongs to cosmetic field, specifically the crease-resistant gentle face conditioning frost of a kind of hirudin and production technology thereof.
Background technology
Scientific research shows: the human skin cell can only absorb the daltonian material in molecular weight≤8000 under normal circumstances.Natural materials in the cosmetics of selling on the market such as hyaluronic acid, SOD and collagen protein etc., its molecular weight mostly is several ten thousand even a hundreds of thousands dalton, thereby be difficult to by skin absorption in full force and effect the deep layer that all needs to rely on the assosting effect of other permeation-promoter to penetrate to the skin.
Natural hirudin (Hirudin) is a kind of material of Hirudo salivary gland secretion, and the single chain polypeptide by 65～66 amino acid residues form does not contain arginine, methionine and tryptophan.The hirudin molecular weight only is 7000 dalton, does not need the auxiliary deep layer that just can directly independently penetrate to the skin of other permeation-promoter, is easily absorbed by Skin Cell.Hirudin independently penetrates into facial blood capillary: reduce the blood viscosity of facial vessels, accelerate the face blood flowing velocity, dredge facial blood capillary.Improve facial microcirculation, promoted to reduce cuticle thickness behind the skin of face metabolism, make cell obtain sufficient nutrient.Improve the self-repairing capability of cell, the growth of check melanin cell, disappear facial sunburn and pigmentation make skin fine and smooth, fair and clear.Hirudin is a kind of polypeptides matter; Be by Amino acid profile but be different from the intermediate material of protein.It has the characteristic of protein, but simpler than protein, and molecular weight is few, is easily absorbed by body.
Sun Zhiyong, Wang Gang etc. are in " natural hirudin is on the experimentation of pig random pattern skin flap venous congestion impact " (Chinese Reconstructive surgery magazine, 2008; 22,11) in, Chen Weihua etc. are in " the topical application hirudin is to the control of Cure of Expanded Flap Venous Congestion " (Chinese practical drainer for plastic surgery magazine, 2005; 16,5) all mention in, the generation of flap venous congestion is from human body blood coagulation mechanism, thrombin plays very important effect in the wound process, hirudin is as the special effect inhibitor of thrombin, but all multiactions of Trombin inhibiting, and aggregate performance is for promoting the congestion diffusion, can effectively prevent and treat Cure of Expanded Flap Venous Congestion by the hirudin interventional therapy, alleviate the venous congestion after random pattern skin flap is transplanted.
Yuan Xiaohui, Wang Wanjie etc. are in " preliminary observation of preventive function of hirudin against proliferative viteoretinopathy " (Recent Advances in Ophthalmology, 2000; 20,4) in, Yang Ying, Zheng Yanlin etc. are in " hirudin is on the impact of the fibroblast growth of In vitro culture " (ophthalmology, 2004; 13,5) mention, by injecting hirudin in the vitreous chamber to experimental external coat animal model, and set up external fibroblasts model etc., observe its turbidity and optical fundus propagation film formational situation, and the fibroblast growth situation of In vitro culture, conclusion is that hirudin can obviously suppress external fibroblastic growth and differentiation, to comprising that the position proliferative diseases such as eye, cornea, bulbar conjunctiva polyp are deformed into and have in early days good preventive effect, thereby can be used as the external raw material of the above-mentioned position for the treatment of proliferative lesion.
Li Xuan, Liu Daen etc. are in " hirudin suppresses the experimentation of in-vitro simulated scar model " (Chinese Chinese medicine magazine, 2009; 24,7) point out in the literary composition that hypertrophic cicatrix is the common disease of burn plastic surgery, fibroblast can cause the unusual disease of various hypertrophy at the abnormality proliferation of different tissue sites and the extracellular matrix excessive secretion that causes.Experimental result shows that hirudin can produce to be suppressed to the functions such as fibrocellular propagation, secretion, contraction by reducing collagen, thereby suppresses generation and the development of hypertrophic cicatrix, thereby can be used for treating hypertrophic cicatrix class disease.And " hirudin is on the structure observation of proliferative vitreoretinopathy impact " (Chinese TCM Ophthalmology magazine, 2000; 01), " hirudin is to the inhibitory action of the Cultured Rabbit Smooth Muscle Cells of cultivation " (Chinese circulation magazine, 1996; 02, Zhou Xiaoming etc.), Ogichit, " Tissue factor and cancer procoagulantexpressed by gliom a cells participate in their throm binmediated proliferation " (Neurooncol, 2000 of Hirashima etc.; 46,1) experiment report etc. has also fully confirmed this point.
Natural hirudin energy and thrombin carry out specific binding, hinder the carrying out of coagulation process, from this angle, natural hirudin has anticoagulation, thrombus, antiinflammatory and the effects such as blood fat reducing, blood viscosity lowering, at present domestic and international research to natural hirudin also concentrates on this, yet be used for from improving tissue blood microcirculation, expansion local organization blood vessel etc., natural hirudin is improving the flap venous congestion, is being suppressed to that fibrocyte is grown up and development, suppresses and removing hypertrophic cicatrix and epidermis fat the aspect such as silt up and has good effect.
Crease-resistant product commonly used is various at present, and effect is variant greatly, usually can't improve skin metabolism, promotes cutaneous circulation, increase skin-nourishing, can't fundamentally remove wrinkle and mottle that skin occurs.And most products contain heavy metal, and safety and sequela be difficult prediction still, if improper use, may after cause the damage of skin.And natural hirudin is a kind of low molecular polypeptide, molecular weight is little, do not need the auxiliary deep layer that just can directly independently penetrate to the skin of other permeation-promoter, the dredging blood capillary reduces blood viscosity, accelerate blood flow rate, improve facial microcirculation, promoted to reduce cuticle thickness behind the skin of face metabolism, make cell obtain sufficient nutrient, improve the self-repairing capability of cell, fundamentally improve skin.So the hirudin anti-wrinkle cosmetic is a kind of new type ideal skin care good product that integrates anti-, controls, makes up.
Summary of the invention
The purpose of this invention is to provide the crease-resistant gentle face conditioning frost of a kind of hirudin, skin corium can independently directly penetrate to the skin, be easy to be absorbed by the skin, can solve because the skin that blood does not freely cause is crossed the problems such as presenility and eye wrinkle-removing, the effect of wrinkle removing stricture of vagina is very good, improve facial microcirculation, have the effect that improves skin quality; The present invention also provides production technology, and is simple to operation.
The crease-resistant gentle face conditioning frost of hirudin of the present invention, made by the raw material of following percentage by weight:
Oil phase raw material: squalane 4-6%, cetyl alcohol/cetyl glucoside 1-3%, Jojoba oil 2-4%, tristerin/PEG-100 stearate 2-4%, dimethicone 0.3-0.7%, sad/certain herbaceous plants with big flowers acid glyceride 0.5-1.5%, cetearyl alcohol 0.5-1.5%, Vitamin E acetate 0.5-1.5%, myristic acid isopropyl 0.5-1.5% and white oil 0.5-1.5%;
Water raw material: glycerol 4-6%, oat polypeptide 4-6%, avenabeta glucosan 2-4%, 1,3 propylene glycol 2-4%, chitosan 2-4%, D pantothenylol 0.5-1.5%, collagen protein polypeptide 0.5-1.5%, crocus sativus 0.5-1.5%, glycyrrhizic acid diformazan 0.3-0.7%, Radix Ginseng extract 0.2-0.4%, diazolidinyl urea 0.2-0.4%, daily essence 0.1-0.2%, HV1-3% and deionized water 53.8-58.8%.
The crease-resistant gentle face conditioning frost of hirudin is preferably made by the raw material of following percentage by weight:
Oil phase raw material: squalane 5%, cetyl alcohol/cetyl glucoside 2%, Jojoba oil 3%, tristerin/PEG-100 stearate 3%, dimethicone 0.5%, sad/certain herbaceous plants with big flowers acid glyceride 1%, cetearyl alcohol 1%, Vitamin E acetate 1%, myristic acid isopropyl 1% and white oil 1%;
Water raw material: glycerol 5%, oat polypeptide 5%, avenabeta glucosan 3%, 1,3 propylene glycol 3%, chitosan 3%, D pantothenylol 1%, collagen protein polypeptide 1%, crocus sativus 1%, glycyrrhizic acid diformazan 0.5%, Radix Ginseng extract 0.3%, diazolidinyl urea 0.3%, daily essence 0.1%, hirudin 2% and deionized water 56.3%.
Wherein the effect of each raw material is as follows:
Squalane: can suppress the peroxidating of skin lipid, can effectively infiltrate through skin, and promote the propagation of skin base cell, to delay skin aging, improving and eliminating chloasma all has obvious physiologic effect.
Cetyl alcohol/cetyl glucoside: emulsifying agent.
Jojoba oil: have the effect of nourishing softening skin.
Tristerin/PEG-100 stearate: emulsifying agent.
Dimethicone: skin moistening.
Sad/the certain herbaceous plants with big flowers acid glyceride: skin moistening.
Vitamin E acetate: antioxidation.
Isopropyl myristate: skin moistening.
White oil: prevent the moisture of skin excessive vaporization.
Glycerol: moisturizing.
Oat polypeptide: strengthen skin elasticity, tighten up and softening tiny wrinkle.
1,3 propylene glycol: moisturizing.
Chitosan: the immunity that improves skin.
The D pantothenylol: the wetting agent that deeply permeates, irritate epithelial growth, promote wound healing, play antiinflammation.
Collagen protein polypeptide: replenish the collagen protein that skin runs off, improve the density of skin, increase the elasticity of skin.
Crocus sativus: activation skin, delay skin aging.
Glycyrrhizic acid diformazan: prevent skin allergy.
Radix Ginseng extract: metabolism, delaying cell aging, the removing free radical of regulating human body.
Diazolidinyl urea: anticorrosion.
Daily essence: covering agent.
Hirudin: the effect of blood circulation promoting and blood stasis dispelling, putrefaction removing and tissue regeneration promoting is arranged, and the skin corium that can independently directly penetrate to the skin is easy to be absorbed by the skin.On the other hand because the effect of antithrombase, to the blood capillary of epidermis and facial microcirculation, good assosting effect has enhanced metabolism.Fundamentally solve because pore stops up the comedo that causes, acne and because the skin that blood does not freely cause is crossed presenility and eye wrinkle-removing, chloasma, freckle, red blood streak etc.
Deionized water: solvent.
The production technology of the crease-resistant gentle face conditioning frost of hirudin of the present invention, carry out according to the following steps:
(1) agitated kettle, oil phase pot and water pot are cleaned with purified water, used ethanol disinfection;
(2) taking by weighing deionized water adds in the water pot, the glycerol, oat polypeptide, the avenabeta glucosan, 1 that add aqueous phase, 3 propylene glycol, chitosan and crocus sativus are heated to 90-100 ℃ of sterilization 18-22 minute, add the collagen protein polypeptide stirring and dissolving of aqueous phase again;
(3) the homogenizing pot is heated to 80-90 ℃ for subsequent use;
(4) with being heated to 80-90 ℃ in all oil phase raw materials adding oil phase pots, then with in the oil phase suction homogenizing pot;
(5) product that step (2) is obtained slowly stirs in the suction homogenizing pot, keeps vacuum state, adds Radix Ginseng extract, D pantothenylol and the glycyrrhizic acid diformazan of aqueous phase, stirring and emulsifying;
(6) homogenizing;
Add diazolidinyl urea, daily essence and the hirudin of aqueous phase when (7) slowly being cooled to 38-42 ℃ under the stirring, stir;
(8) be down to discharging after the room temperature, the record of weighing;
(9) sampling detection, fill, outsourcing get product.
Wherein:
Preparation before producing is: take by weighing respectively oil phase with plastic containers; With glycerol, oat polypeptide, avenabeta glucosan, 1,3 propylene glycol, chitosan, D pantothenylol, collagen protein polypeptide and the crocus sativus of plastics appearance with aqueous phase, for subsequent use; Take by weighing respectively glycyrrhizic acid diformazan, Radix Ginseng extract, diazolidinyl urea, daily essence and the hirudin of aqueous phase with beaker, for subsequent use; Take by weighing each material, container tool and instrument are special-purpose, must not obscure, and weighing is complete to be indicated at material package, stand-by.Must be strictly during weighing by claim, the requirements such as multiple, note, mark carry out.
Ethanol is 75% ethanol in the step (1).
The rotating speed of homogenizing pot remains on 38-42r/min in the step (4).
The stirring and emulsifying time is 28-32 minute in the step (5).
Processing condition is in the step (6): temperature is 73-77 ℃, and the time is 8-12 minute, and speed controlling is at 2900-3100r/min.
Speed of agitator is 50-60r/min in the step (7),, the time is 13-17 minute.
The present invention has the following advantages:
(1) skin corium that can independently directly penetrate to the skin, be easy to be absorbed by the skin, can solve because the skin that blood does not freely cause is crossed the problems such as presenility and eye wrinkle-removing, the effect of wrinkle removing stricture of vagina is very good, improve simultaneously facial microcirculation, have the effect that improves skin quality;
(2) add multiple skin-moisturizing, skin antioxidative raw material, the crease-resistant microgroove effect of going is very good;
(3) production technology is simple to operation.
The specific embodiment
The present invention will be further described below in conjunction with embodiment.
Embodiment 1
(1) agitated kettle, oil phase pot and water pot are cleaned with purified water, used 75% ethanol disinfection;
(2) taking by weighing the 56.3kg deionized water adds in the water pot, add 5kg glycerol, 5kg oat polypeptide, 3kg avenabeta glucosan, 3kg1,3 propylene glycol, 3kg chitosan and 1kg crocus sativus are heated to 95 ℃ of sterilizations 20 minutes, add 1kg collagen protein polypeptide stirring and dissolving again;
(3) the homogenizing pot is heated to 85 ℃ for subsequent use;
(4) will be heated to 85 ℃ in all oil phase raw materials adding oil phase pots, then with in the oil phase suction homogenizing pot, the rotating speed of homogenizing pot remains on 40r/min;
(5) product that step (2) is obtained slowly stirs in the suction homogenizing pot, keeps vacuum state, adds 0.3kg Radix Ginseng extract, 1kgD pantothenylol and 0.5kg glycyrrhizic acid diformazan, stirring and emulsifying 30 minutes;
(6) temperature is 75 ℃, and speed controlling is at 3000r/min, homogenizing 10 minutes.
Add 0.3kg diazolidinyl urea, 0.1kg daily essence and 2kg hirudin when (7) slowly being cooled to 40 ℃ under the stirring, stirred 15 minutes, speed of agitator is 50r/min;
(8) be down to discharging after the room temperature, the record of weighing;
(9) sampling detection, fill, outsourcing get product.
Embodiment 2
(1) agitated kettle, oil phase pot and water pot are cleaned with purified water, used 75% ethanol disinfection;
(2) taking by weighing the 53.8kg deionized water adds in the water pot, add 6kg glycerol, 6kg oat polypeptide, 2kg avenabeta glucosan, 2kg1,3 propylene glycol, 4kg chitosan and 1.5kg crocus sativus are heated to 90 ℃ of sterilizations 22 minutes, add 0.5kg collagen protein polypeptide stirring and dissolving again;
(3) the homogenizing pot is heated to 90 ℃ for subsequent use;
(4) will be heated to 80 ℃ in all oil phase raw materials adding oil phase pots, then with in the oil phase suction homogenizing pot, the rotating speed of homogenizing pot remains on 40r/min;
(5) product that step (2) is obtained slowly stirs in the suction homogenizing pot, keeps vacuum state, adds 0.2kg Radix Ginseng extract, 0.5kgD pantothenylol and 0.7kg glycyrrhizic acid diformazan, stirring and emulsifying 32 minutes;
(6) temperature is 73 ℃, and speed controlling is at 3100r/min, homogenizing 8 minutes.
Add 0.4kg diazolidinyl urea, 0.2kg daily essence and 1kg hirudin when (7) slowly being cooled to 42 ℃ under the stirring, stirred 17 minutes, speed of agitator is 50r/min;
(8) be down to discharging after the room temperature, the record of weighing;
(9) sampling detection, fill, outsourcing get product.
Embodiment 3
(1) agitated kettle, oil phase pot and water pot are cleaned with purified water, used 75% ethanol disinfection;
(2) taking by weighing the 58.8kg deionized water adds in the water pot, add 4kg glycerol, 4kg oat polypeptide, 4kg avenabeta glucosan, 4kg1,3 propylene glycol, 2kg chitosan and 0.5kg crocus sativus are heated to 100 ℃ of sterilizations 18 minutes, add 1.5kg collagen protein polypeptide stirring and dissolving again;
(3) the homogenizing pot is heated to 80 ℃ for subsequent use;
(4) will be heated to 90 ℃ in all oil phase raw materials adding oil phase pots, then with in the oil phase suction homogenizing pot, the rotating speed of homogenizing pot remains on 40r/min;
(5) product that step (2) is obtained slowly stirs in the suction homogenizing pot, keeps vacuum state, adds 0.4kg Radix Ginseng extract, 1.5kgD pantothenylol and 0.3kg glycyrrhizic acid diformazan, stirring and emulsifying 28 minutes;
(6) temperature is 77 ℃, and speed controlling is at 2900r/min, homogenizing 12 minutes.
Add 0.2kg diazolidinyl urea, 0.1kg daily essence and 3kg hirudin when (7) slowly being cooled to 38 ℃ under the stirring, stirred 13 minutes, speed of agitator is 60r/min;
(8) be down to discharging after the room temperature, the record of weighing;
(9) sampling detection, fill, outsourcing get product.
Claims (7)
1. the crease-resistant gentle face conditioning of hirudin is white, and it is characterized in that: the raw material by following percentage by weight is made:
Oil phase raw material: squalane 4-6%, cetyl alcohol/cetyl glucoside 1-3%, Jojoba oil 2-4%, tristerin/PEG-100 stearate 2-4%, dimethicone 0.3-0.7%, sad/certain herbaceous plants with big flowers acid glyceride 0.5-1.5%, cetearyl alcohol 0.5-1.5%, Vitamin E acetate 0.5-1.5%, myristic acid isopropyl 0.5-1.5% and white oil 0.5-1.5%;
Water raw material: glycerol 4-6%, oat polypeptide 4-6%, avenabeta glucosan 2-4%, 1,3 propylene glycol 2-4%, chitosan 2-4%, D pantothenylol 0.5-1.5%, collagen protein polypeptide 0.5-1.5%, crocus sativus 0.5-1.5%, glycyrrhizic acid diformazan 0.3-0.7%, Radix Ginseng extract 0.2-0.4%, diazolidinyl urea 0.2-0.4%, daily essence 0.1-0.2%, HV1-3% and deionized water 53.8-58.8%.
2. the crease-resistant gentle face conditioning of hirudin according to claim 1 is white, and it is characterized in that: the raw material by following percentage by weight is made:
Oil phase raw material: squalane 5%, cetyl alcohol/cetyl glucoside 2%, Jojoba oil 3%, tristerin/PEG-100 stearate 3%, dimethicone 0.5%, sad/certain herbaceous plants with big flowers acid glyceride 1%, cetearyl alcohol 1%, Vitamin E acetate 1%, myristic acid isopropyl 1% and white oil 1%;
Water raw material: glycerol 5%, oat polypeptide 5%, avenabeta glucosan 3%, 1,3 propylene glycol 3%, chitosan 3%, D pantothenylol 1%, collagen protein polypeptide 1%, crocus sativus 1%, glycyrrhizic acid diformazan 0.5%, Radix Ginseng extract 0.3%, diazolidinyl urea 0.3%, daily essence 0.1%, hirudin 2% and deionized water 56.3%.
3. the production technology of the crease-resistant gentle face conditioning frost of a claim 1 or 2 described hirudins is characterized in that: carry out according to the following steps:
(1) agitated kettle, oil phase pot and water pot are cleaned with purified water, used ethanol disinfection;
(2) taking by weighing deionized water adds in the water pot, the glycerol, oat polypeptide, the avenabeta glucosan, 1 that add aqueous phase, 3 propylene glycol, chitosan and crocus sativus are heated to 90-100 ℃ of sterilization 18-22 minute, add the collagen protein polypeptide stirring and dissolving of aqueous phase again;
(3) the homogenizing pot is heated to 80-90 ℃ for subsequent use;
(4) with being heated to 80-90 ℃ in all oil phase raw materials adding oil phase pots, then with in the oil phase suction homogenizing pot;
(5) product that step (2) is obtained slowly stirs in the suction homogenizing pot, keeps vacuum state, adds Radix Ginseng extract, D pantothenylol and the glycyrrhizic acid diformazan of aqueous phase, stirring and emulsifying;
(6) homogenizing;
Add diazolidinyl urea, daily essence and the hirudin of aqueous phase when (7) slowly being cooled to 38-42 ℃ under the stirring, stir;
(8) be down to discharging after the room temperature, the record of weighing;
(9) sampling detection, fill, outsourcing get product.
4. the crease-resistant gentle face of hirudin according to claim 3 is nursed one's health the production technology of frost, and it is characterized in that: the rotating speed of homogenizing pot remains on 38-42r/min in the step (4).
5. the crease-resistant gentle face of hirudin according to claim 3 is nursed one's health the production technology of frost, and it is characterized in that: the stirring and emulsifying time is 28-32 minute in the step (5).
6. the crease-resistant gentle face of hirudin according to claim 3 is nursed one's health the production technology of frost, and it is characterized in that: processing condition is in the step (6): temperature is 73-77 ℃, and the time is 8-12 minute, and speed controlling is at 2900-3100r/min.
7. the crease-resistant gentle face of hirudin according to claim 3 is nursed one's health the production technology of frost, and it is characterized in that: speed of agitator is 50-60r/min in the step (7), and the time is 13-17 minute.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210560378.8A CN103006512B (en) | 2012-12-21 | 2012-12-21 | Hirudin anti-winkle face-softening conditioning cream and production process thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210560378.8A CN103006512B (en) | 2012-12-21 | 2012-12-21 | Hirudin anti-winkle face-softening conditioning cream and production process thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103006512A true CN103006512A (en) | 2013-04-03 |
| CN103006512B CN103006512B (en) | 2014-06-11 |
Family
ID=47955981
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201210560378.8A Active CN103006512B (en) | 2012-12-21 | 2012-12-21 | Hirudin anti-winkle face-softening conditioning cream and production process thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN103006512B (en) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107510619A (en) * | 2017-09-06 | 2017-12-26 | 深圳肽之妃科技有限公司 | A kind of complex polypeptide facial mask and preparation method thereof |
| CN107519037A (en) * | 2017-09-06 | 2017-12-29 | 深圳肽之妃科技有限公司 | A kind of liquid facial mask containing polypeptide and preparation method thereof and application method |
| CN107854326A (en) * | 2017-12-19 | 2018-03-30 | 乳山寰海生物科技有限公司 | A kind of hirudin moistens face moisturizing maintenance Essence |
| CN109453059A (en) * | 2018-12-26 | 2019-03-12 | 广州市科能化妆品科研有限公司 | Skin-lightening cosmetic additive and whitening sleep mask and preparation method thereof |
| US11446286B1 (en) | 2022-02-28 | 2022-09-20 | King Faisal University | Treatment of fungal infections using dabigatran etexilate |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1522689A (en) * | 2003-09-12 | 2004-08-25 | 周维海 | Leech extract cosmetics and method for making same |
| CN1660041A (en) * | 2004-02-24 | 2005-08-31 | 刘凤鸣 | Application of hirudinoid protease chalone incosmetic |
| CN102178635A (en) * | 2011-04-27 | 2011-09-14 | 重庆时珍阁普生药业有限公司 | Use of leech for cleaning skin, skin cleaning composition and preparation method thereof |
-
2012
- 2012-12-21 CN CN201210560378.8A patent/CN103006512B/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1522689A (en) * | 2003-09-12 | 2004-08-25 | 周维海 | Leech extract cosmetics and method for making same |
| CN1660041A (en) * | 2004-02-24 | 2005-08-31 | 刘凤鸣 | Application of hirudinoid protease chalone incosmetic |
| CN102178635A (en) * | 2011-04-27 | 2011-09-14 | 重庆时珍阁普生药业有限公司 | Use of leech for cleaning skin, skin cleaning composition and preparation method thereof |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107510619A (en) * | 2017-09-06 | 2017-12-26 | 深圳肽之妃科技有限公司 | A kind of complex polypeptide facial mask and preparation method thereof |
| CN107519037A (en) * | 2017-09-06 | 2017-12-29 | 深圳肽之妃科技有限公司 | A kind of liquid facial mask containing polypeptide and preparation method thereof and application method |
| CN107510619B (en) * | 2017-09-06 | 2020-11-24 | 深圳肽之妃科技有限公司 | Composite polypeptide mask and preparation method thereof |
| CN107854326A (en) * | 2017-12-19 | 2018-03-30 | 乳山寰海生物科技有限公司 | A kind of hirudin moistens face moisturizing maintenance Essence |
| CN109453059A (en) * | 2018-12-26 | 2019-03-12 | 广州市科能化妆品科研有限公司 | Skin-lightening cosmetic additive and whitening sleep mask and preparation method thereof |
| US11446286B1 (en) | 2022-02-28 | 2022-09-20 | King Faisal University | Treatment of fungal infections using dabigatran etexilate |
Also Published As
| Publication number | Publication date |
|---|---|
| CN103006512B (en) | 2014-06-11 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN103006511B (en) | Hirudin skin-whitening moisture-keeping conditioning cream and production process thereof | |
| CN109620748B (en) | Anti-wrinkle essence and preparation method thereof | |
| CN101214200B (en) | Skin externally-applied liquid state and solid state kreotoxin (liushengtai) composite nano emulsion and preparation thereof | |
| CN103505403B (en) | Epidermal growth factor composite liposome body and its preparation method and application | |
| CN103585097B (en) | Epidermal growth factor-loaded bletilla rhizome polysaccharide compound, and preparation method and application thereof | |
| CN104856892A (en) | Cosmetic or skin care product preparation rich in growth factors and preparation method therefor | |
| CN103006512B (en) | Hirudin anti-winkle face-softening conditioning cream and production process thereof | |
| CN105963153A (en) | Active composition containing copper peptide and cosmetic or skin care product | |
| CN105193673B (en) | A kind of clear acne repairs liquid and preparation method thereof | |
| JP2009513581A (en) | Latex or topical formulation containing this fraction and cosmetic treatment method | |
| CN101791283B (en) | Cosmetic capable of eliminating striae gravidarum and scars | |
| CN105662896B (en) | A kind of lecithin liposome embedding calophyllum inophyllum kernel oil and its application in calming down light scar product | |
| CN102274141B (en) | Herba selaginellae revival moisturizing cream and preparation method thereof | |
| CN109431854A (en) | A kind of bFGF acne hole maintenance freeze-dried powder preparation and preparation method thereof | |
| CN112941010A (en) | Plant callus efficacy filtrate and exosome extraction method | |
| CN104055716A (en) | Vitamin restoring essence | |
| CN114288221A (en) | A method for preparing essence containing polypeptide and plant extractive solution with hair growth promoting effect and its application | |
| CN103479567B (en) | Epidermal growth factor complex liposome and its preparation method and application | |
| CN105232393A (en) | Beautifying composition with classic efficacies of invigorating blood circulation, removing spots, resisting wrinkles and keeping young and application of beautifying composition | |
| CN102266373A (en) | Skin externally-used matrix for treating scar and preparation method thereof | |
| WO2015163838A1 (en) | Skin treatment formulations | |
| CN104323966A (en) | Golden hydrotherapy composition and using method thereof | |
| CN107028830A (en) | It is a kind of to prevent the medicine and its preparation technology of scar hyperplasia | |
| KR20200080687A (en) | Composition For External Skin Application For Preventing Pigmentation and Promoting Skin Regeneration and a Manufacturing Method Thereof | |
| CN113476385A (en) | A bath gel containing multiple natural plant effective components for whitening skin, benefiting skin and repairing skin, and its preparation method |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20190611 Address after: 256300 No. 2 Gaoyuan East Road, Gaoqing County, Zibo City, Shandong Province Patentee after: Zibo overseas medical supplies Limited by Share Ltd Address before: 256300 No. 13 Qinghe Road, Gaoqing County, Zibo City, Shandong Province Patentee before: Shandong Qiaopai Group Co., Ltd. |
|
| TR01 | Transfer of patent right |