CN102989089A - Ultrasonic focusing device for treating Parkinson's disease - Google Patents
Ultrasonic focusing device for treating Parkinson's disease Download PDFInfo
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- CN102989089A CN102989089A CN2012105858880A CN201210585888A CN102989089A CN 102989089 A CN102989089 A CN 102989089A CN 2012105858880 A CN2012105858880 A CN 2012105858880A CN 201210585888 A CN201210585888 A CN 201210585888A CN 102989089 A CN102989089 A CN 102989089A
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Abstract
本发明公开了一种治疗帕金森综合症的超声聚焦设备，由磁共振扫描装置、超声发射装置、超声信息设置装置、超声显像装置、磁共振信息转化装置和磁共振图像显示系统构成，磁共振扫描装置与磁共振信息转化装置连接，磁共振扫描装置与磁共振图像显示系统和超声信息设置装置连接，超声信息设置装置与超声发射装置和超声显像装置连接。该设备利用功能磁共振对脑结构定位，定位准确。
The invention discloses an ultrasonic focusing device for treating Parkinson's syndrome, which is composed of a magnetic resonance scanning device, an ultrasonic emitting device, an ultrasonic information setting device, an ultrasonic imaging device, a magnetic resonance information conversion device and a magnetic resonance image display system. The resonance scanning device is connected with the magnetic resonance information conversion device, the magnetic resonance scanning device is connected with the magnetic resonance image display system and the ultrasonic information setting device, and the ultrasonic information setting device is connected with the ultrasonic emitting device and the ultrasonic imaging device. The device uses functional magnetic resonance to locate the brain structure, and the positioning is accurate.
Description
Technical field
The invention belongs to the armarium technical field, relate to a kind of burnt equipment of ultrasonic copolymerization for the treatment of parkinsonism.
Background technology
Parkinson disease (PD) are a kind of gradual nervous system degenerative diseases, it is characterized in that bradykinesia, and are stiff, tremble trunk forerunner tendency and astasia during rest.
Clinical employing surgery brain be implanted into deep brain stimulation (deep brain stimulation, DBS is commonly called as: brain pacemaker) Zeng Qiang ?the matter irritability, it is active to improve DA.At present since magnetic Resonance Imaging MRI and (electronic computer x-ray tomography technology) can accurately locate each nerve nucleus (Bao Kuo of brain ?matter and striatum.In recent years because the development of molecular imaging can be carried out the function phenomenon to partial nerve cell in the nuclear group.Except the brain pacemaker of deep, the RFcoagulation damage treatment of rising gradually in recent years is the treatment critical treatment method of brain stereotactic operation, is used for the treatment of PD.In addition, the treatment such as electrical transcranial stimulation has been used for the PD treatment, but uncertain therapeutic efficacy is cut.
The brain pacemaker has the following disadvantages: implant microelectrode at Cerebrum nucleus and improve symptom, cerebral hemorrhage and cerebral edema may occur in postoperative, symptomatic recurrence in some patients were postoperative a period of time; There is the patient of serious cardiopulmonary kidney disease, unmanageable hypertension and spiritedness symptom to use; Other somewhat expensive, present one-sided treatment need more than 10 ten thousand yuan approximately, and bilateral treatment needs more than 20 ten thousand yuan approximately, need the periodic replacement battery, and required expense is higher, and general patient often is difficult to bear; Be prone to simultaneously equipment fault.
High intensity focused ultrasound as a kind of new oncotherapy means so that some lose surgical engine can get old and weak the tumour patient that loses the Radiotherapy chemotherapy chance provide treatment may, and obtained widely approval.Focus ultrasonic utilizes ultrasound wave as the energy exactly.A lot of bundle ultrasound wave go from external being transmitted in the health, in the middle of the transmission process, focus on, focusing on a point is on the tumor, transform by sound wave and heat energy, in 0.5～1 second, form 70 ℃～100 ℃ hyperthermia treatment points, it is that a scalpel is cutting tumor that this high temperature dot cans be compared to, and none escapes by luck the tumor of focal area.Focus ultrasonic knife makes tumor tissues produce coagulation necrosis, loses propagation, infiltration and transfer ability.This machine principle is similar to the poly-sunlight of solar cooker and produces huge energy in the focus place.Therefore, use the MRI molecular image and learn a skill, use high intensity focused ultrasound and destroy an amount of Ach neuronal cell, make its activity decreased, make ?matter-striatal DA and Ach reach new balance, clinical cure PD is the clinical approach that can select.
RFcoagulation damage treatment: by the altofrequency electromagnetic wave, destroy striatal cholinergic neuron treatment PD.Cerebral hemorrhage and cerebral edema may occur in the postoperative that this scheme has overcome the brain pacemaker; There is the patient of serious cardiopulmonary kidney disease, unmanageable hypertension and spiritedness symptom to use; In addition, the defective of somewhat expensive and equipment fault.RFcoagulation damage treatment shortcoming: the damage envelope difficulty is confined to very among a small circle (about 100 microns), may damage the peripheral nerve structure, causes critical function unusual.
Summary of the invention
In order to solve the problems of the technologies described above, the invention provides that a kind of therapeutic effect is remarkable, side effect is little, the focus ultrasonic equipment of the treatment parkinsonism that cost is low, its technical scheme is as follows:
A kind of focus ultrasonic equipment for the treatment of parkinsonism is made of magnetic resonance imaging equipment 1, ultrasonic transmitter 2, ultrasound information setting device 3, ultrasonoscopy device 4, magnetic resonance information transformation device 5 and magnetic resonance image (MRI) display system 6.Magnetic resonance imaging equipment 1 is connected with magnetic resonance information transformation device 5, and magnetic resonance imaging equipment 1 is connected with the ultrasound information setting device with magnetic resonance image (MRI) display system 6 and is connected, and ultrasound information setting device 3 is connected with the ultrasonoscopy device with ultrasonic transmitter 2 and is connected.
Further preferred, the quantity of described ultrasonic transmitter 2 is 3.
The principle of equipment of the present invention is: the parkinson pathogenesis be since the aging Dao Zhi of nervous system ?matter striatal dopamine neuron Dopamine Secreted mediator reduce, cholinergic neuron is active to be strengthened relatively.Clinical treatment parkinson Main Means is to replenish dopamine, active, the antagonism acetylcholine active treatment of activation dopamine neuron at present.This equipment principle: locate cholinergic neuron with functional MRI, can accurately locate and destroy 100 microns left and right sides architectural characteristics with ultrasonic copolymerization Jiao, destroy cholinergic neuron, thereby subtract the cholinergic transmitter in few ?matter striatum zone, thus treatment PD.
Compared with prior art, beneficial effect of the present invention: this device first utilizes ultrasonic copolymerization Jiao can destroy the more Magnocellular characteristic of single volume, Po Huai ?matter striatum cholinergic neuron, the treatment parkinson disease.First from Po Hua ?matter striatum cholinergic neuron set about, the treatment parkinson disease.Utilize first ultrasonic copolymerization burnt, the accurate characteristics of focusing range are destroyed single neuron.This equipment filled up domestic and international useless destruction Nao ?the blank of the cholinergic neuron special for treating PD of matter striatum system, compare the various complication that can reduce operation of opening cranium with operative treatment PD, in time aftereffect assessment is repeatedly treated simultaneously, reaches the effect of therapeutic purposes.Compare can avoid Long-term taking medicine to bring constant with Drug therapy, and side effects of pharmaceutical drugs (acting on the effect of other cholinergic neurons in the body).Therefore this equipment with existing treatment means compare have safe, convenient, feasible, side effect is little, simultaneously than operative treatment with Drug therapy is more economical for a long time.The following aspect of main manifestations:
(1) utilize functional MRI to brain structure location, accurate positioning;
(2) can accurately break the cholinergic neuron in bad ?matter striatum zone, thereby reduce the secretion of acetylcholine;
(3) more do not need operation of opening cranium with deep brain electromagnetic technique treatment PD;
(3) controllability is good, and assessment can repeated multiple timesly be treated, until reach therapeutic purposes after the treatment.
Description of drawings
Fig. 1 is the structure chart that the present invention treats the burnt equipment of ultrasonic copolymerization of parkinsonism.
The specific embodiment
Below in conjunction with the drawings and specific embodiments technical scheme of the present invention is described in more detail.
With reference to Fig. 1, a kind of focus ultrasonic equipment for the treatment of parkinsonism, consisted of by magnetic resonance imaging equipment 1, ultrasonic transmitter 2, ultrasound information setting device 3, ultrasonoscopy device 4, magnetic resonance information transformation device 5 and magnetic resonance image (MRI) display system 6, magnetic resonance imaging equipment 1 is connected with magnetic resonance information transformation device 5, magnetic resonance imaging equipment 1 is connected with the ultrasound information setting device with magnetic resonance image (MRI) display system 6 and is connected, and ultrasound information setting device 3 is connected with the ultrasonoscopy device with ultrasonic transmitter 2 and is connected.Magnetic resonance imaging equipment 1 is connected with magnetic resonance information transformation device 5, and magnetic resonance imaging equipment 1 is connected with the ultrasound information setting device with magnetic resonance image (MRI) display system 6 and is connected, and ultrasound information setting device 3 is connected with the ultrasonoscopy device with ultrasonic transmitter 2 and is connected.The quantity of described ultrasonic transmitter 2 is 3.
Equipment of the present invention in use, magnetic resonance imaging equipment 1 scanning, the information of scanning is sent to magnetic resonance information transformation device 5, magnetic resonance information transforms 5 information that will sweep magnetic resonance imaging equipment 1 scanning and changes, the information of scanning passes to ultrasound information setting device 3 simultaneously, ultrasound information setting device 3 passes to demonstration with this information and passes to ultrasonoscopy device 4, ultrasound information setting device 3 is integrated the information that comes from magnetic resonance information transformation device 5, and the burnt position of ultrasonic copolymerization is set, and with this position display on ultrasonoscopy device 4, device 3 arranges the burnt position of copolymerization according to the information from 5, and be sent to device 2,2 and send ultrasonic damage and show neuron.Cooperate functional MRI show Da Nao ?matter striatum cholinergic neuron, by magnetic resonance information transformation device 5 process informations, target image is presented on the magnetic resonance image (MRI) display system 6.
This equipment mainly can destroy people's in-vivo tissue structure with the burnt high temperature that forms of ultrasonic copolymerization.The at present burnt treatment of ultrasonic copolymerization tumor technology maturation, wide clinical application.But the burnt treatment of ultrasonic copolymerization tumor, general focusing range is large, and the volume that destroys tumor tissues is larger.The ultrasound destruction cell is neuronal cell in this device, and about neurocyte diameter 100 μ m, therefore, the precision to copolymerization Jiao in this device fixes on 100 μ m.At present to treatment of Parkinson disease adopt to replenish dopamine, Ji Huo ?matter striatal dopamine neuron, the treatment of cholinergic agonist drug.This device is at present unique accurate broken bad ?matter striatum cholinergic neuron therapeutic equipment, and this device uses present functional MRI to cerebral nerve meta function phenomenon, accurately to show and to show ?matter striatal neuron.?matter striatum cholinergic neuron diameter at 100 μ m, in the true scope of ultrasonic copolymerization pyrogene, theoretical feasible.
This equipment is the task equipment of a treatment PD, this equipment comprises functional MRI function and the burnt function of ultrasonic copolymerization, utilize the accurate definite position of a functional MRI ?matter striatum cholinergic neuron, accurately locate with the burnt equipment division of ultrasonic copolymerization, focus among a small circle and form high-order disorganize structure.This equipment treatment same cholinergic antagonist of PD (trihexyphenidyl, benzhexol etc.) has common target spot, and same mechanism; But this equipment treatment more remarkable treatment effect is avoided the inconvenience of Long-term taking medicine and to the side effect of other histoorgans.
The above only is best mode for carrying out the invention, anyly is familiar with those skilled in the art in the technical scope that the present invention discloses, and the simple change of the technical scheme that can obtain apparently or equivalence are replaced and all fallen within the scope of protection of the present invention.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107303407A (en) * | 2016-04-18 | 2017-10-31 | 曲锰 | The quick ablation treating system of lung cancer |
| WO2019119188A1 (en) * | 2017-12-18 | 2019-06-27 | 深圳先进技术研究院 | Magnetic compatibility brain ultrasonic stimulation device and manufacturing method therefor |
| US11167154B2 (en) | 2012-08-22 | 2021-11-09 | Medtronic, Inc. | Ultrasound diagnostic and therapy management system and associated method |
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| US6128522A (en) * | 1997-05-23 | 2000-10-03 | Transurgical, Inc. | MRI-guided therapeutic unit and methods |
| CN1672651A (en) * | 2004-02-17 | 2005-09-28 | 西门子共同研究公司 | System and method for patient positioning for radiotherapy in the presence of respiratory motion |
| CN203060612U (en) * | 2012-12-28 | 2013-07-17 | 成都信息工程学院 | Ultrasonic focusing device for treating Parkinson's disease |
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- 2012-12-28 CN CN2012105858880A patent/CN102989089A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6128522A (en) * | 1997-05-23 | 2000-10-03 | Transurgical, Inc. | MRI-guided therapeutic unit and methods |
| CN1672651A (en) * | 2004-02-17 | 2005-09-28 | 西门子共同研究公司 | System and method for patient positioning for radiotherapy in the presence of respiratory motion |
| CN203060612U (en) * | 2012-12-28 | 2013-07-17 | 成都信息工程学院 | Ultrasonic focusing device for treating Parkinson's disease |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11167154B2 (en) | 2012-08-22 | 2021-11-09 | Medtronic, Inc. | Ultrasound diagnostic and therapy management system and associated method |
| CN107303407A (en) * | 2016-04-18 | 2017-10-31 | 曲锰 | The quick ablation treating system of lung cancer |
| WO2019119188A1 (en) * | 2017-12-18 | 2019-06-27 | 深圳先进技术研究院 | Magnetic compatibility brain ultrasonic stimulation device and manufacturing method therefor |
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Inventor after: Huang Changchuo Inventor after: Guo Panpan Inventor after: Yang Xiaoping Inventor after: Li Yonghong Inventor after: Peng Xiaodong Inventor after: Wang Hui Inventor after: Liu Qingxiu Inventor after: Liu Liang Inventor after: Tao Rong Inventor after: Zeng Chengyu Inventor after: Yu Hang Inventor before: Huang Changchuo Inventor before: Li Yonghong Inventor before: Peng Xiaodong Inventor before: Wang Hui Inventor before: Liu Qingxiu Inventor before: Liu Liang Inventor before: Tao Rong |
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Free format text: CORRECT: INVENTOR; FROM: HUANG CHANGQUAN LI YONGHONG PENG XIAODONG WANG HUI LIU QINGXIU LIU LIANG TAO RONG TO: HUANG CHANGQUAN LI YONGHONG PENG XIAODONG WANG HUI LIU QINGXIU LIU LIANG TAO RONG CENG CHENGYU YU HANG GUO PANPAN YANG XIAOPING |
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Application publication date: 20130327 |