CN102987092A - Feed additive for improving disease resistance of escherichia coli - Google Patents
Feed additive for improving disease resistance of escherichia coli Download PDFInfo
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- CN102987092A CN102987092A CN2012103771933A CN201210377193A CN102987092A CN 102987092 A CN102987092 A CN 102987092A CN 2012103771933 A CN2012103771933 A CN 2012103771933A CN 201210377193 A CN201210377193 A CN 201210377193A CN 102987092 A CN102987092 A CN 102987092A
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- 241000588724 Escherichia coli Species 0.000 title abstract description 11
- 239000003674 animal food additive Substances 0.000 title abstract description 8
- 208000035240 Disease Resistance Diseases 0.000 title abstract 2
- 240000005528 Arctium lappa Species 0.000 claims abstract description 11
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- 235000003130 Arctium lappa Nutrition 0.000 claims abstract description 10
- 239000002994 raw material Substances 0.000 claims abstract description 9
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- 239000010440 gypsum Substances 0.000 claims abstract description 4
- 241000282887 Suidae Species 0.000 claims description 17
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 16
- 239000000463 material Substances 0.000 claims description 15
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- 240000004980 Rheum officinale Species 0.000 claims description 10
- 235000008081 Rheum officinale Nutrition 0.000 claims description 10
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- 238000005303 weighing Methods 0.000 claims description 8
- 238000009835 boiling Methods 0.000 claims description 5
- 238000000605 extraction Methods 0.000 claims description 5
- 239000000843 powder Substances 0.000 claims description 5
- 238000010298 pulverizing process Methods 0.000 claims description 5
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- 238000011049 filling Methods 0.000 claims description 4
- 239000012467 final product Substances 0.000 claims description 2
- 210000000936 intestine Anatomy 0.000 abstract description 4
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- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 2
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- 206010028140 Mucous stools Diseases 0.000 description 1
- 206010030113 Oedema Diseases 0.000 description 1
- 241000758742 Saururaceae Species 0.000 description 1
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- WNROFYMDJYEPJX-UHFFFAOYSA-K aluminium hydroxide Chemical compound [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 description 1
- 229910021502 aluminium hydroxide Inorganic materials 0.000 description 1
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- Feed For Specific Animals (AREA)
- Fodder In General (AREA)
Abstract
The invention relates to a feed additive for improving disease resistance of escherichia coli. The feed additive is prepared from 18-24 parts of burdock, 15-20 parts of herba patriniae, 15-20 parts of cordate houttuynia, 12-16 parts of folium isatidis, 12-16 parts of radix sophorae flavescentis, 8-12 parts of submerged root rhubarb, and 3-5 parts of gypsum as raw materials. The feed additive disclosed by the invention plays the roles of resisting viruses, clearing heat, diminishing inflammation, detoxifying, invigorating stomach, dehumidifying, breaking through intestines and regulating the flow of vital energy, and also can prevent and treat colibacillosis. Therefore, the recovery rate and the daily gain of piglets are improved, and the mortality of the piglets is reduced.
Description
Technical field
The invention belongs to field of feed additive technology, relate to a kind of feed addictive that improves the colibacillosis of pigs resistance.
Background technology
At present, piglet yellow-white dysentery all has generation all over the world, country such as the U.S. that pig industry is flourishing, and the incidence of disease of its piglet yellow-white dysentery is about 20%, the death rate is 15.5%.According to statistics, the morbidity number of China 2001-2003 piglet yellow scour is 104511, and direct economic loss reaches 5,000 ten thousand yuan.Have data to show China's East China Large-Scaled Swine Farms, the piglet yellow-white dysentery average attack rate is 29.0%, and average mortality is 20.4%.If piglet yellow-white dysentery and other swine disease mixed infection, its piglet death rate can reach more than 60%.Yellow dysentery is mainly in 7 ages in days with interior suckling pig, and sick pig main manifestations is row's yellow or yellow-white watery stools, and the death rate can reach more than 80%, even 100%.Dysentery characterized by white mucous stool is mainly in 10-30 age in days piglet, and sick swine excrement is milky white or canescence, and the incidence of disease can reach 80%, and the morbidity age in days of swine escherichia coli diarrhoea has prolongation trend at present, is 60 ages in days, and coliform diarrhea also occurs the weanling pig of 60 ~ 90 ages in days.Oedema is multiple is born in 1-2 piglet in age in week after the wean, and the incidence of disease is lower, but case fatality rate reaches more than 90%.The generation of piglet yellow scour is without seasonality, and is in close relations with environmental sanitation, such as stress factor, overcast and rainy moist, cold and hot indefinite, breast milk is not enough, circle is filthy etc. all can inspire the yellow dysentery of pig and occur.The generation of the white scour of piglet is relevant with the maternal antibody minimizing with flora imbalance, and with various stress factor close relationship is arranged.Hydropsy for baby pigs throughout the year all can be popular, but with spring and autumn, rainy seasonal prevalence.Physically fit, eutrophy, the piglet of body weight about 10 ~ 40kg this disease that mostly occurs.Many flip-floies owing to feed and method for breeding, overcast and rainy humidity, feeding manner flip-flop etc. can make the piglet resistance descend, and all can bring out this disease.
The method of preventing and treating of colibacillosis of pigs is a lot, such as passing through to sow vaccinate later stage of pregnancy, make newborn piglet come study and use of adaptive immune power, oneself seedling of swine escherichia coli etc. by maternal antibody, because bacillus coli antigen complex structure, its serotype is quite a lot of again, so prevention effect is all not ideal.Present clinically with maximum still treating by antibacterials, but because Escherichia coli more easily produce drug resistance, the extensive use of antibacterials constantly increases antibody-resistant bacterium especially recently.In addition, the western medicine colibacillosis of pigs mainly is to use antibacterials, although can suppress or kill many enteropathogenic E．Colis like this, but in the body enteron aisle except enteropathogenic E．Coli, also have a large amount of non-pathogenic floras, they have important function to the eubolism of body, when using antimicrobial blindly, to suppress or kill non-pathogenic bacteria group in the body enteron aisle, and destroy its composition structure, the digestive function of body is had a strong impact on, thereby cause series of problems.Traditional Chinese veterinary medicine control colibacillosis of pigs except restraining and sterilizing bacteria, is also paid attention to adjusting improving the organism physiology situation, namely treats both principal and secondary aspect of disease.
In sum, a kind of take plant extracts as active component by researching and developing, have the feed addictive that improves the colibacillosis of pigs resistance, this seems particularly necessary.
Summary of the invention
The present invention is directed to the present situation that Colibacillosis is many in the present large-scale cultivation, harm is large; sum up existing Chinese herbal medicine formula; and carry out on the basis of existing technology science increase and decrease restructuring, thereby provide a kind of feed addictive that improves the colibacillosis of pigs resistance.This Chinese herbal feed additive can satisfy prevention and the needs for the treatment of colibacillosis in the pig large-scale cultivation.
The object of the present invention is achieved like this:
A kind of feed addictive that improves the colibacillosis of pigs resistance, by great burdock achene 18-24 part, field pennycress 15-20 part, cordate houttuynia 15-20 part, folium isatidis 12-16 part, kuh-seng 12-16 part, water root rheum officinale 8-12 part and gypsum 3-5 part are prepared from as raw material.
The amount ratio of described raw material is preferably: 22 parts of great burdock achenes, 18 parts of field pennycress, 18 parts of cordate houttuynias, 4 parts of 14 parts of folium isatidis, 14 parts of kuh-sengs, 10 parts of water root rheum officinales and gypsums.
The present invention be used for to improve the feed addictive of colibacillosis of pigs resistance, be pulverized and mixed after described raw material can being taken by weighing according to the recipe quantity proportioning and finished product.
Further preferably, the present invention is used for improving the feed addictive of colibacillosis of pigs resistance, is prepared from as follows: take by weighing dry described raw material, mix, pulverize, add water and cover powder, soak 1-1.2h, pull out medicinal material put multi-functional extraction fill with in twice of boiling, add up for the first time the water that medicinal material 8-12 doubly measures, decocted 2-4 hour, and got decocting liquid, filter, add up for the second time the water that medicinal material 6-10 doubly measures, decocted 2-4 hour, and got twice decocting liquid and merge, filter, relative density is the concentrate of 1.20-1.25 when being concentrated into 90 ℃, with the concentrate spray-drying, dried extract is through pulverizing, and get final product.
Described spray-dired condition is that EAT is 100 ℃, and leaving air temp is 80 ℃, and temperature of charge is 80 ℃, and atomizing pressure is 0.2MPa, and spray velocity is 5ml/s.
The selected great burdock achene of the present invention is the dry mature fruit of feverfew burdock Arctium lappa L.; Field pennycress has another name called Chinese ixeris herb, is the whole herb with root of feverfew Chinese ixeris herb; Cordate houttuynia is the dry above water of Saururaceae herbaceos perennial heartleaf houttuynia; Folium isatidis is the branches and leaves of cruciferae isatis; Kuh-seng is the root of the perennial semishrub plant's kuh-seng of falling leaves; Water root rheum officinale is that rheum officinale is excavated the supporting root that adds the excision in man-hour after being unearthed; The gypsum main component is hydrous calcium sulfate.Iron, magnesium etc. that a small amount of silicic acid, aluminium hydroxide, sulfide and trace are still arranged in addition.
The effect that medium-height grass extract feed additive of the present invention has is antiviral, heat-clearing, anti-inflammatory, detoxifcation, stomach invigorating, dehumidifying, logical intestines are regulated the flow of vital energy.Can find out according to above result of the test; use the Chinese herbal medicine extract feed addictive of the present invention piglet of feeding; can effectively prevent and treat colibacillosis; improve cure rate and piglet daily gain; reduce the piglet death toll; generation for prevention and control colibacillosis of piglet strengthens the resistance of livestock and poultry, and protection animal husbandry develops in a healthy way and has important practical significance and economic implications.
The specific embodiment
Below be the concrete preparation example of feed addictive of the present invention, technical scheme of the present invention is done further the description, but protection scope of the present invention is not limited to these embodiment.Every do not deviate from the change of the present invention design or be equal to substitute include within protection scope of the present invention.
The preparation of embodiment 1 feed addictive
Take by weighing 22 kilograms of clean and dry great burdock achenes, 18 kilograms of field pennycress, 18 kilograms of cordate houttuynias, 14 kilograms of folium isatidis, 14 kilograms of kuh-sengs, 4 kilograms of 10 kilograms of water root rheum officinales and gypsums mix, and pulverize, add water and cover powder, soak 1-1.2h, pull medicinal material out and put boiling twice in the multi-functional extraction filling, add up the water of 10 times of amounts of medicinal material for the first time, decocted 3 hours, get decocting liquid, filter, add up the water of 8 times of amounts of medicinal material for the second time, decocted 2 hours, get twice decocting liquid and merge, filter, relative density is 1.20 concentrate when being concentrated into 90 ℃, with the concentrate spray-drying, spray-dired condition is that EAT is 100 ℃, and leaving air temp is 80 ℃, and temperature of charge is 80 ℃, atomizing pressure is 0.2MPa, spray velocity is 5ml/s, and dried extract namely gets feed addictive through pulverizing.
The preparation of embodiment 2 feed addictives
Take by weighing 18 kilograms of clean and dry great burdock achenes, 18 kilograms of field pennycress, 15 kilograms of cordate houttuynias, 16 kilograms of folium isatidis, 12 kilograms of kuh-sengs, 4 kilograms of 8 kilograms of water root rheum officinales and gypsums mix, and pulverize, add water and cover powder, soak 1-1.2h, pull medicinal material out and put boiling twice in the multi-functional extraction filling, add up the water of 10 times of amounts of medicinal material for the first time, decocted 3 hours, get decocting liquid, filter, add up the water of 8 times of amounts of medicinal material for the second time, decocted 2 hours, get twice decocting liquid and merge, filter, relative density is 1.20 concentrate when being concentrated into 90 ℃, with the concentrate spray-drying, spray-dired condition is that EAT is 100 ℃, and leaving air temp is 80 ℃, and temperature of charge is 80 ℃, atomizing pressure is 0.2MPa, spray velocity is 5ml/s, and dried extract namely gets feed addictive through pulverizing.
The preparation of embodiment 3 feed addictives
Take by weighing 24 kilograms of clean and dry great burdock achenes, 15 kilograms of field pennycress, 20 kilograms of cordate houttuynias, 14 kilograms of folium isatidis, 16 kilograms of kuh-sengs, 3 kilograms of 12 kilograms of water root rheum officinales and gypsums mix, and pulverize, add water and cover powder, soak 1-1.2h, pull medicinal material out and put boiling twice in the multi-functional extraction filling, add up the water of 10 times of amounts of medicinal material for the first time, decocted 3 hours, get decocting liquid, filter, add up the water of 8 times of amounts of medicinal material for the second time, decocted 2 hours, get twice decocting liquid and merge, filter, relative density is 1.20 concentrate when being concentrated into 90 ℃, with the concentrate spray-drying, spray-dired condition is that EAT is 100 ℃, and leaving air temp is 80 ℃, and temperature of charge is 80 ℃, atomizing pressure is 0.2MPa, spray velocity is 5ml/s, and dried extract namely gets feed addictive through pulverizing.
The preparation of embodiment 4 feed addictives
Take by weighing 24 kilograms of clean and dry great burdock achenes, 15 kilograms of field pennycress, 20 kilograms of cordate houttuynias, 3 kilograms of 14 kilograms of folium isatidis, 16 kilograms of kuh-sengs, 12 kilograms of water root rheum officinales and gypsums are pulverized, and mix, and namely get feed addictive.
Embodiment 5 feed addictives are on the impact of colibacillosis of pigs
140 of the white commodity piglets of length in 3 ages in week, body weight 20kg ± 2kg does not use any antibacterials.Experimental animal is divided into 5 groups at random, except 20 of blank groups, and several 40 of all the other each treated animals.The complete feed that does not contain medicine is all fed in all test pig stable breedings.
Swine escherichia coli O
78Inoculate fresh broth bouillon, place 37 ℃ of insulating boxs to cultivate 16-18h, the agar plate semar technique calculates it and contains the bacterium number, swine escherichia coli O
78Containing the bacterium number is 9.6 hundred million/mL.
Each group is attacked the poison amount and is the swine escherichia coli O of the above-mentioned preparation of every pig intramuscular injection 5mL
78Bacterium liquid, observe after the inoculation each group test piglet spirit, search for food, the clinical settings such as drinking-water, ight soil, breathing, and give feed addictive by the mode of table 1, be used in conjunction 5 days.Dead piglet is carried out pathology immediately cut open inspection, bacterial isolate is cultivated from liver.Infect after inoculation 1-5 days control group morbidity piglet death time.Cuing open the inspection relatively outstanding pathology of pig of dying of illness is: the acute catarrh inflammation of enteron aisle, and wherein serious with duodenum, the intestinal tube inflation, the intestines wall is thin and transparent, and is separable to swine escherichia coli O from the pig liver of dying of illness
78
Table 1 test grouping and Feed formulation
| Process | Sample size (head) | Diet forms |
| Normal group | 20 | The basis diet |
| Model control group | 40 | The basis diet |
| Test I group | 40 | Basis diet+0.1% embodiment, 1 feed addictive |
| Test II group | 40 | Basis diet+1% embodiment, 4 feed addictives |
The index of assessment of curative effect of feed addictive is as follows:
Cure: clinical symptoms complete obiteration after the feed addictive treatment, spirit and diet wish recover normal for curing, and statistics is cured number and calculated cure rate;
Produce effects: clinical symptoms obviously alleviate after the feed addictive treatment, and spirit and diet wish improvement person count computational efficiency for treatment produce effects, statistics produce effects;
Effectively: be cure rate and obvious effective rate sum;
Invalid: symptom does not disappear after feed addictive treatment, and during the treatment because this sick died is all invalid, the statistics invalid number calculates inefficiency;
Average weight gain: according to giving before the feed addictive and the body weight of every pig during off-test, calculate the gain in weight of every pig, calculate accordingly every group of average weight gain.
The relative weight gain: the relative weight gain rate is to calculate by the ratio of each group with the average weight gain of Normal group.
Table 2 feed addictive is on the impact of wean swine escherichia coli and production performance
| Index | Model control group | Test I group | Test II group |
| Cure rate (%) | - | 95 | 62.5 |
| Obvious effective rate (%) | - | 5 | 32.5 |
| Efficient (%) | - | 100 | 95 |
| Inefficiency (%) | 87.5 | 0 | 5 |
| Death toll (head) | 29 | 0 | 1 |
| Average weight gain (%) | 1.09±0.21 | 2.15±0.20 **##￥￥ | 1.69±0.18 |
| The relative weight gain (%) | 49.3 | 97.4 | 67.5 |
Compare with model control group,
* P＜0.05,
* P＜0.01.
The effect that medium-height grass extract feed additive of the present invention has is antiviral, heat-clearing, anti-inflammatory, detoxifcation, stomach invigorating, dehumidifying, logical intestines are regulated the flow of vital energy.Result of the test according to table 2 can be found out; use the Chinese herbal medicine extract feed addictive of the present invention piglet of feeding; can effectively prevent and treat colibacillosis; improve cure rate and piglet daily gain; reduce the piglet death toll; generation for prevention and control colibacillosis of piglet strengthens the resistance of livestock and poultry, and protection animal husbandry develops in a healthy way and has important practical significance and economic implications.
Claims (5)
1. feed addictive that improves the colibacillosis of pigs resistance, it is characterized in that: by great burdock achene 18-24 part, field pennycress 15-20 part, cordate houttuynia 15-20 part, folium isatidis 12-16 part, kuh-seng 12-16 part, water root rheum officinale 8-12 part and gypsum 3-5 part are prepared from as raw material.
2. the feed addictive of raising colibacillosis of pigs resistance according to claim 1, it is characterized in that: the amount ratio of described raw material is: 22 parts of great burdock achenes, 18 parts of field pennycress, 18 parts of cordate houttuynias, 4 parts of 14 parts of folium isatidis, 14 parts of kuh-sengs, 10 parts of water root rheum officinales and gypsums.
3. the feed addictive of raising colibacillosis of pigs resistance according to claim 1 and 2 is characterized in that: be pulverized and mixed after described raw material is taken by weighing and get.
4. the feed addictive of raising colibacillosis of pigs resistance according to claim 1 and 2, it is characterized in that being prepared from as follows: take by weighing dry described raw material, mix, pulverize, add water and cover powder, soak 1-1.2h, pull medicinal material out and put boiling twice in the multi-functional extraction filling, add up the water that medicinal material 8-12 doubly measures for the first time, decocted 2-4 hour, get decocting liquid, filter, add up the water that medicinal material 6-10 doubly measures for the second time, decocted 2-4 hour, getting twice decocting liquid merges, filter, relative density is the concentrate of 1.20-1.25 when being concentrated into 90 ℃, with the concentrate spray-drying, dried extract is through pulverizing, and get final product.
5. the feed addictive of raising colibacillosis of pigs resistance according to claim 4, it is characterized in that: spray-dired condition is that EAT is 100 ℃, and leaving air temp is 80 ℃, and temperature of charge is 80 ℃, atomizing pressure is 0.2MPa, and spray velocity is 5ml/s.
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| CN201210377193.3A CN102987092B (en) | 2012-10-08 | 2012-10-08 | Feed additive for improving disease resistance of escherichia coli |
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|---|---|---|---|
| CN201210377193.3A CN102987092B (en) | 2012-10-08 | 2012-10-08 | Feed additive for improving disease resistance of escherichia coli |
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| CN102987092B CN102987092B (en) | 2014-01-08 |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106177221A (en) * | 2016-08-18 | 2016-12-07 | 中国农业科学院兰州畜牧与兽药研究所 | A kind of Chinese medicine composition for treating swine escherichia coli diarrhoea and preparation method thereof |
| CN106721044A (en) * | 2017-03-06 | 2017-05-31 | 长沙瑞多康生物科技有限公司 | A kind of feed of prevention colibacillosis of pigs |
| CN106798128A (en) * | 2017-03-06 | 2017-06-06 | 长沙瑞多康生物科技有限公司 | A kind of feed of prevention colibacillosis of pigs |
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| CN108743693A (en) * | 2018-08-28 | 2018-11-06 | 江苏农牧科技职业学院 | A kind of piglet health care growth promotion Chinese medicine composition, preparation method and applications |
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| CN106858103A (en) * | 2017-03-06 | 2017-06-20 | 长沙瑞多康生物科技有限公司 | A kind of feed of prevention colibacillosis of pigs |
| CN108743693A (en) * | 2018-08-28 | 2018-11-06 | 江苏农牧科技职业学院 | A kind of piglet health care growth promotion Chinese medicine composition, preparation method and applications |
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