There is defibrillator and the two-phase sawtooth square wave defibrillation electrion method of extended pattern H bridge road output stage
Technical field
The invention belongs to medical electronics technical field, be specifically related to a kind of cardiac defibrillator with output-stage circuit, and defibrillation electrion method.
Background technology
Cardiac sudden death (SCD) is to occur the unexpected type circulation collapse that immediately occurs in 1 hour and to asystole, be the major causes of death of cardiovascular disease in clinical symptoms.The epidemiological study result at U.S.'s health statistics center shows, exceedes 50% for SCD in all cardiovascular deaths, and the SCD sum of annual China is more than 54.4 ten thousand examples; In the past few decades, along with the generation of aged tendency of population process SCD is on the rise simultaneously.Wherein, 80% SCD is owing to malignant ventricular arrhythmia, as ventricular fibrillation (VF is called for short chamber and quivers).Because the chamber malignant ventricular arrhythmia such as quiver shows effect often without omen, when outbreak, the electrical activity of ventricle loses synchronicity, and cardiac pumping function is lost, and turns the multiple rhythm of the heart as taken measures not in time, will cause dying suddenly within several minutes.And this wherein exceedes 90% chamber and quiver outside patient's morbidity place Shi hospital, often cannot obtain in time treatment.So the chamber of termination is quivered, recovered the normal heart rhythm and pace of moving things, recovers hemodynamic stability within the short as far as possible time, be to avoid and effectively prevent the top priority that SCD occurs.At present, a kind of unique method that can effectively stop myocardium fibrillation is electric defibrillation (ED is called for short defibrillation) clinically, heart is carried out to High Voltage electric shock, makes myocardial cell repolarization, gets back to affective state separately, restarts normally to beat.The appearance of automated external defibrillator (AED) makes early stage defibrillation outside hospital become possibility, and the intelligent characteristic of its " identification automatically, automatic analysis, automatic defibrillation " becomes simple by electric defibrillation operation, the amateur common people also can take on the spot in time SCD patient is implemented to defibrillation rescue, shorten rescue time, improve the rescue survival rate of SCD.
The electric current that defibrillator discharges should be the minimum energy of can the chamber of termination quivering, and the threshold current of general adult's electric defibrillation is 10~25 amperes, and energy is 50~300 joules.Energy is excessive or electric current is too high not only can cause myocardial damage and skin burn, and can be larger to organic heart damages such as ischemic hearts.The electric energy of defibrillator output is to be finally discharged into it patient by certain discharge waveform.Therefore, in order to reduce the excessive side effect of myocardial damage and defibrillation, Chinese scholars has been carried out a large amount of research to defibrillation charging method and waveform, and some discharge waveforms that once and used comprise: single-phase damping sinusoidal wave, single-phase index chopped wave, two-phase index chopped wave, burst pulse array two-phase index chopped wave etc.Experimentation confirms, when defibrillation with biphasic wave, the required potential gradient meansigma methods of cardiac muscle be only 1/2 of single-phase ripple, and during accordingly also by single-phase DC defibrillation 360 joules of required defibrillation energy are significantly reduced to 200 joules.As can be seen here, while applying equal defibrillation energy on an equal basis, the success rate of two-phase ripple is far above single-phase ripple.At present, medical circle not yet has generally acknowledged conclusion for the electrophysiological mechanism of defibrillation technology, defibrillator on market or AED mostly are the two-phase defibrillation ripple of exponential damping type, make every effort to, in ensureing the higher synchronous defibrillation success rate of myocardial cell, realize the damage minimum to heart with minimum discharge energy as far as possible.
The breast impedance of general human body is 20~150 ohm of left and right, there is larger individual variation, existing defibrillator, conventionally according to the breast impedance magnitude measuring, changes discharge inception voltage amplitude or the discharge waveform width of two-phase defibrillation ripple, reaches discharge energy self adaptation regulation and control.The defibrillation charging method that Chinese patent 200510120801.2A " Waveform generating method of defibrillation two-phase ripple " is described, its waveform parameter comprises fixing pulse period and adjustable discharge inception voltage.Chinese patent 200580047116.A " has at the automated external defibrillator (AED) that forms the discrete sensing pulse using in treatment biphasic waveform ", this sensing pulse is used for the special parameters such as the breast impedance of definite patient before discharging defibrillation waveform, and based on this parameter adjustment discharge waveform.Chinese patent 200710046179.4A " realizes method and the device of low energy defibrillation " by burst pulse be in the time that the discharge waveform of defibrillation is two-phase index truncation exponential wave, and each pulsewidth of clicking is adjustable between 0.5ms~4ms.Chinese patent 200910061191.1 " Intelligent intermediate-frequency bi-directional square wave defibrillation method " detects breast impedance with the intermediate frequency constant current of 5KHz, and corresponding adjusting discharge waveform parameter, patient is sent to the two-phase defibrillation clump shape pulse square wave of 5KHz intermediate frequency.US Patent No. 6,671,546 and patent US6, the multiple-pulse two-phase wave technology of 493,580 disclosed a kind of similar higher frequencies, fixes the cycle of first-phase defibrillation pulse and second-phase defibrillation pulse, and biphasic waveform is divided into multiple narrow pulse waveforms and forms.Although above patent and all adopted two-phase defibrillation ripple, positive and anti-phase essence are to only have a ripple, are high pressure exponential damping decline form.Its main deficiency is: the spike part passageway of (1) exponential wave exceedes Defibrillator threshold, not only wastes energy but also easily produced strong stimulation to cardiac muscle generation damage; (2) energy control deviation is larger, and the energy that defibrillator discharges is adjusted according to breast impedance, and the more difficult individuation that realizes is accurately controlled, particularly high especially the or low especially patient of impedance; (3) the spike part of exponential wave, requires the capacitor energy of higher starting voltage and the defibrillation output stage of Geng Gao requirement of withstand voltage, has increased design complexities and the manufacturing cost of defibrillator device.
Summary of the invention
The object of the invention is to propose a kind of cardiac defibrillator with extended pattern H bridge high voltage discharge circuit road output stage for above-mentioned the deficiencies in the prior art; The two-phase sawtooth square wave electrion method with boost function based on this extended pattern H bridge road output stage is proposed simultaneously, so that for different patients, the defibrillation electric energy that individuation is accurately controlled is more provided, obtain the electric discharge output voltage higher than energy-storage capacitor source voltage simultaneously, reduce the high pressure characteristics on electric discharge bridge road is required and save device cost.
The two-phase sawtooth waveforms defibrillation charging method with boost function that the present invention proposes, by comprising an extended pattern H bridge road defibrillator output stage with inductance coil, with predefined a series of bridge way switch combinations and control strategy, by induction electric energy in the electric energy in energy-storage capacitor and inductance coil with merge (or individually) mode, the impulse form being superimposed upon on two-phase square wave with the thin ripple of sawtooth via defibrillation electrode is carried out once high-voltage electric shock electric discharge rapidly with it patient, reach cessative aspect ventricular Fibrillation with this, reduce high pressure defibrillation to myocardium damage, realize the object that patient is rescued in time, wherein, defibrillation discharge voltage can be higher than the output source voltage of energy-storage capacitor, and the output control of defibrillation electric energy obtains more accurately and controls according to individual patients difference.
Specifically being constructed as follows of extended pattern H bridge road defibrillator output stage proposed by the invention: formed by least one energy-storage capacitor, an inductance coil, a current sensor and many gauge taps, wherein, many interconnected formations of gauge tap are with the extended pattern H bridge circuit switch on three Ge Shubeiqiao roads and two transverse arm bridge roads, gauge tap forms high voltage discharge circuit according to predetermined sequential, exports the defibrillation electric current of diphasic pulse via defibrillation electrode to patient.Wherein:
In described defibrillator output stage, by controlling the compound mode of extended pattern H bridge circuit switch, can form the inductive energy storage Qiao Lu loop that at least one comprises energy-storage capacitor and inductance coil;
In described defibrillator output stage, by controlling the compound mode of extended pattern H bridge circuit switch, can form at least one patient who comprises that energy-storage capacitor is connected with patient Qiao Lu loop of discharging;
In described defibrillator output stage, by controlling the compound mode of extended pattern H bridge circuit switch, can form at least one patient who comprises that inductance coil, energy-storage capacitor and patient are connected Qiao Lu loop of discharging;
In described defibrillator output stage, described current sensor is placed in patient discharge Qiao Lu loop or inductive energy storage Qiao Lu loop, the amplitude of this loop current of sensing in real time in discharge process.
The basic structure of described defibrillator output stage as shown in Figure 3.
Use the cardiac defibrillator of defibrillator output stage of the present invention, wherein, except defibrillator output stage, comprising: main control module, battery module, breast impedance and electrocardiogram acquisition analysis module, human-computer interaction module and wireless communication module, also have high-voltage charging module in addition.High-voltage charging module provides high-tension electricity for the device output stage of quivering; Breast impedance and electrocardiogram acquisition analysis module, human-computer interaction module and wireless communication module, be connected with main control module respectively, is subject to master control module controls; Defibrillator output stage is connected with main control module, and in defibrillator output stage, the interconnected formation of gauge tap, with the extended pattern H bridge circuit switch on three Ge Shubeiqiao roads and two transverse arm bridge roads, is all subject to master control module controls.Its structure can be referring to shown in Fig. 4 or Fig. 5.
The defibrillation charging method based on above-mentioned extended pattern H bridge road defibrillator output stage that the present invention provides, concrete steps are as follows:
The first step, appearance can be shocked by electricity after the rhythm of the heart advise defibrillation electric discharge, and the charging that completes energy-storage capacitor is prepared, and sets discharge current parameter, comprises reference interval value, positive sawtooth waveforms sum and the anti-phase sawtooth waveforms sum of discharge current amplitude;
Second step, control the compound mode of H bridge circuit switch, form described positive inductance bridge road energy storage, carry out discharge energy-storage by energy-storage capacitor to inductance coil, the current amplitude of inductance coil of flowing through thus also progressively raises, and Real-time Feedback is to the current sensor on same bridge road;
The 3rd step, when being elevated to the upper of preset reference interval, the electric current on this current sensor prescribes a time limit, control H bridge circuit switch combination mode and (disconnect positive inductive energy storage bridge road, and be communicated with the positive patient bridge road of discharging), electric energy and energy-storage capacitor merging by the inductance coil of responding to are carried out defibrillation electric discharge to patient simultaneously, and on the current sensor on Real-time Feedback Dao Gaiqiao road;
The 4th step, when being reduced to the lower of preset reference interval, the discharge current on this current sensor prescribes a time limit, the compound mode of controlling H bridge circuit switch (disconnects the positive patient bridge road of discharging, and be communicated with positive inductive energy storage bridge road), increase a sawtooth waveforms counting simultaneously, and compare with default positive sawtooth waveforms sum, as deficiency, repeat second step~four step.
The 5th step, completes after the electric discharge of positive sawtooth pulse, controls the compound mode of H bridge circuit switch, by similar second step~four step, implements anti-phase sawtooth pulse electric discharge.
In the present invention, described in there is the two-phase sawtooth waveforms defibrillation charging method of boost function, can, by controlling the compound mode of H bridge circuit switch, also can be operated in decompression mode.
In the present invention, be to be that main controller is realized by microcontroller (MCU) to the control of H bridge circuit switch combination mode.
In the present invention, current sensor can be realized by ohmage, and the current value measuring is input to described microcontroller, with reference value relatively after, then export and control the compound mode of H bridge circuit switch by microcontroller.
In the present invention, described H bridge circuit switch is one or more IGBT or SCR switch.
Use the cardiac defibrillator with extended pattern H bridge road defibrillation output stage provided by the invention, and adopt above-mentioned defibrillation charging method, can be according to the shocked by electricity abnormal electrocardiogram information detecting and patient's breast impedance, automatically preset defibrillation discharge waveform parameter, and export two-phase sawtooth square wave high-voltage electric shock electric current to patient immediately.Current sensor in its extended pattern H bridge road detects the amplitude of discharge current in electric defibrillation process in real time, and compare with default current amplitude reference interval value, and then by conducting positive (or anti-phase) inductive energy storage bridge road rising current amplitude (when amplitude lower than interval under in limited time), or conducting positive (or anti-phase) patient discharge bridge road reduce current amplitude (when amplitude higher than interval under in limited time), obtain a defibrillation discharge current that presents two-phase zig-zag with it patient thus, its defibrillation discharge voltage can be higher than the output source voltage of energy-storage capacitor, the requirement of the spike part of having avoided existing two-phase exponential wave to the higher starting voltage of high voltage discharge circuit, the functional reliability that is conducive to reduce the cost of defibrillator electrion output stage and increases circuit, meanwhile, defibrillation waveform is not only less to patient's myocardial damage, and the synchronous defibrillation success rate that shocks by electricity also improves a lot, and for patient's difference of different breast impedances, can provide the accurate shock energy control of individuation more.
Brief description of the drawings
Fig. 1 is defibrillation control of discharge flow chart of the present invention.
Fig. 2 is the defibrillation discharge current waveform schematic diagram of Fig. 1.
Fig. 3 is a kind of defibrillation electric discharge extended pattern H bridge road schematic diagram of the embodiment of the present invention.
Fig. 4 is a kind of automated external defibrillator device (AED) block diagram of Fig. 3 embodiment.
Fig. 5 is another kind of automated external defibrillator device (AED) block diagram of Fig. 3 embodiment.
Fig. 6 is the defibrillation discharge waveform schematic diagram of Fig. 4 and Fig. 5 embodiment.
Detailed description of the invention
Further set forth and explanation the present invention below in conjunction with most preferred embodiment shown in the drawings:
With reference to accompanying drawing 1, Fig. 2 and Fig. 3, the electrion method realizing based on a kind of extended pattern H bridge road defibrillation output stage (2), according to the shocked by electricity abnormal electrocardiogram information detecting and patient's breast impedance, automatically preset the defibrillation discharge waveform parameter (interval Imax+~Imin+ of positive current reference, anti-phase Imax-~Imin-, positive sawtooth waveforms sum M and anti-phase sawtooth waveforms sum N), and export two-phase sawtooth square wave high-voltage electric shock electric current (I to patient immediately
p).It is characterized in that the current sensor (R in extended pattern H bridge road defibrillation output stage (2)
por R
l) detect in real time discharge current (I in electric defibrillation process
por I
l) amplitude, and compare with default current amplitude reference interval value, and then by conducting positive inductive energy storage bridge road (S1-L-R
l-S6, or anti-phase inductive energy storage bridge road S5-L-R
l-S3) rising current amplitude (when amplitude lower than interval under in limited time), or the conducting positive patient bridge road (S1-L-patient-R that discharges
p-S4, or anti-phase S2-patient-R
p-L-S3) reduce current amplitude (when amplitude higher than interval under in limited time), obtain a defibrillation discharge current (4) that presents two-phase zig-zag with it patient thus, its voltage can be higher than the voltage of storage capacitor; Its step is as follows:
The 1st step, appearance can be shocked by electricity after the rhythm of the heart advise defibrillation electric discharge, the charging that completes energy-storage capacitor is prepared, and set discharge current parameter, comprise reference interval value (the interval Imax+~Imin+ of positive current reference, anti-phase Imax-~Imin-), positive sawtooth waveforms sum (M) and the anti-phase sawtooth waveforms sum (N) of discharge current amplitude;
The 2nd step (
t 0 moment), the compound mode of control bridge way switch, forms positive inductive energy storage bridge road (S1-L-R as claimed in claim 1
l-S6), discharged to inductance coil (L) by energy-storage capacitor (C), the current amplitude (I of the inductance coil of flowing through thus
p) also progressively raise, and Real-time Feedback is to (R on the current sensor on same bridge road
l);
The 3rd step (
t 1 moment), as this current sensor (R
l) on electric current be elevated to upper in limited time (Imax+) in preset reference interval, control bridge way switch compound mode and (disconnect inductive energy storage bridge road S1-L-patient-R
p-S4, and be communicated with the positive patient bridge road S1-L-patient-R that discharges
p-S4), patient is carried out to defibrillation electric discharge by the inductance coil of responding to and energy-storage capacitor simultaneously, and on the current sensor on Real-time Feedback Dao Gaiqiao road;
The 4th step (
t 2 moment), when being reduced to the lower of preset reference interval, the discharge current on this current sensor prescribes a time limit, the compound mode of controlling bridge way switch (disconnects the positive patient bridge road of discharging, and be communicated with inductive energy storage bridge road), increase a sawtooth waveforms counting simultaneously, and compare with default positive sawtooth waveforms sum, as deficiency, repeat 2nd~4 steps.
The 5th step, complete after positive sawtooth pulse electric discharge (
t 3 moment), control the compound mode of bridge way switch, by similar 2nd~4 steps implement anti-phase sawtooth pulse electric discharge (
t 4 ~t 6 moment).
With reference to accompanying drawing 3, a kind of two-phase sawtooth square wave defibrillation charging method with boost function, by comprising the extended pattern H bridge road defibrillator output stage (2) of a band inductance coil (L), formed by least one energy-storage capacitor (C) and many gauge taps (S1 ~ S6), wherein, the interconnected formation of gauge tap is with three Ge Shubeiqiao roads (S1-S3, S5-S6, S2-S4) and two transverse arm bridge road (R
p-patient, R
l-L) extended pattern H bridge circuit, gauge tap forms high voltage discharge circuit according to predetermined sequential, exports the defibrillation electric current (I of diphasic pulse via defibrillation electrode (3) to patient
p); Realize thus by induction electric energy in the electric energy in energy-storage capacitor (C) and inductance coil (L) respectively or merge via defibrillation electrode and carry out once high-voltage electric shock electric discharge rapidly with the impulse form of two-phase sawtooth waveforms with it patient, reach cessative aspect ventricular Fibrillation with this, realize the object that patient is rescued in time.The two-phase sawtooth square wave defibrillation charging method of the present invention that the present embodiment adopts, can provide the electric discharge output voltage higher than energy-storage capacitor source voltage, is conducive to reduce the high pressure characteristics on electric discharge bridge road is required and save device cost; Meanwhile, the thin ripple of the sawtooth of generation is superimposed upon the defibrillation discharge current on two-phase square wave, can be the defibrillation electric energy that patient provides individuation accurately to control, the myocardial damage while being conducive to improve the success rate of heart electric defibrillation and effectively reduce high pressure defibrillation.Concrete formation and the feature of the defibrillator output stage that the defibrillation charging method that the present invention provides is used are as follows:
Described defibrillator output stage (2), by controlling the compound mode of extended pattern H bridge way switch, can form positive inductive energy storage Qiao Lu loop (S1-L-S6) or anti-phase inductive energy storage Qiao Lu loop (S5-L-S3) that at least one comprises energy-storage capacitor (C) and inductance coil (L);
Described defibrillator output stage (2), by controlling the compound mode of extended pattern H bridge way switch, can form at least one positive patient who comprises that inductance coil (L) is connected with patient with energy-storage capacitor (C) Qiao Lu loop (S1-L-patient-S4) or anti-phase patient Qiao Lu loop (S2-patient-L-S3) of discharging of discharging;
Described defibrillator output stage (2), by controlling the compound mode of extended pattern H bridge way switch, can form at least one positive patient who comprises that energy-storage capacitor (C) is connected with patient Qiao Lu loop (S3-L-patient-S4) or anti-phase patient Qiao Lu loop (S1-S2-patient-L) of discharging of discharging;
Described defibrillator output stage (2), at least comprises a current sensor (R
por R
l), this current sensor is placed in the patient Qiao Lu loop (or inductive energy storage Qiao Lu loop) of discharging, this branch current of sensing (I in real time in discharge process
por I
l) amplitude.
With reference to accompanying drawing 4, adopt a kind of embodiment automated external defibrillator device of the present invention (AED) block diagram, its system is configured to: the main control module (8) based on microprocessor is core, is connected respectively to the functional modules such as the physiological parameter such as electrocardio and breast impedance acquisition module (5), human-computer interaction module (6), wireless communication module (7), high-voltage charging module (10), defibrillation electric discharge H bridge road module (11) by the corresponding interface; The unification of above-mentioned functions module is by lithium battery (9) power supply, and is all placed in an airtight frivolous high strength portable box body, is connected to patient body-surface (1) by two defibrillation electrode sheets (3).Above-mentioned AED device can be operated in the daily circulation self-inspection state of battery saving mode and the electric defibrillation duty of first aid pattern.When electric defibrillation duty, each module work is controlled and is coordinated in its primary control program or embedded OS unification, comprise: preset personalized accurate discharge waveform parameter according to measured patient chest impedance information, once patient's to be rescued ecg information passes through automatic analysis continuously, its result presents can shock by electricity the rhythm of the heart time, primary control program, by the two-phase sawtooth square wave electrion method of sending immediately charging instruction and provide according to the present invention, carries out the rescue of high-voltage electric shock defibrillation; In addition in whole rescue process, above-mentioned AED device by auxiliary in sound and light prompt, substep instructs rescuer to complete a series of save operations such as " being placed with electric shock, artificial respiration, CPR external chest compression, defibrillation electric discharge ", said apparatus also can rescue whole defibrillation the information such as ecg information, control instruction and the device parameter of event and all deposit, for carry out event replay and analysis by wireless communication module output afterwards.Wherein, type selecting and the working method of the described each main hardware part of defibrillation electric discharge H bridge road output stage are as follows:
Described output stage H bridge road (11) high side switch (S1, S2, S5) select IGBT, low-side switch (S3, S4, S6) select thyrister form SCR switch, or only less one be IGBT, all there is main control module (8) on H bridge road all switches (S1 ~ S6) according to electrion method of the present invention control;
With reference to accompanying drawing 5 and Fig. 6, adopt another kind of embodiment automated external defibrillator device of the present invention (AED) block diagram, its given H bridge road is on the basis on above-described embodiment H bridge road, to have done further improvement, comprising:
Described defibrillator output stage (12), increases a fly-wheel diode in parallel (D) at energy-storage capacitor (C) two ends, form the self discharge fundamental circuit (C-S7-D) of defibrillator;
Described defibrillator output stage (12), inductive energy storage bridge road when positive and negative phase discharge is S7-R
l-L-S6;
Described defibrillator output stage (12), the one electric discharge bridge road of boosting comprises the positive patient bridge road S7-R that discharges
l-L-patient-S1-R
p-S4 and the anti-phase patient bridge road S7-R that discharges
l-L-patient-S2-R
p-S3, can realize the electric energy of energy-storage capacitor thus and the electric energy merging of inductance coil induction is carried out defibrillation electric discharge to patient, and it exports the voltage (Uc) of discharge voltage higher than energy-storage capacitor, thereby realizes the discharging function that boosts, and defibrillation discharge current is wherein by R
ldetect and obtain.
Described defibrillator output stage (12), a kind of electric discharge bridge road of blood pressure lowering mode comprises the positive patient bridge road D-L-S1-patient-R that discharges
p-S4 and the anti-phase patient bridge road D-L-S2-patient-R that discharges
p-S3, the electric energy that can realize thus inductance coil induction carries out defibrillation electric discharge to patient individually, and its output discharge voltage is lower than the voltage of energy-storage capacitor (Uc '), and defibrillation discharge current is wherein by R
pdetect and obtain.
The discharge waveform parameter of the main control module (8) of above-mentioned AED device based on setting, according to electrion method of the present invention and control strategy, adjust and change the H bridge arrangement of output stage, thereby export to patient the discharge current that boosts that is sawtooth square-wave waveform within the scope of certain amplitude described in enforcement this patent, final realization quiver patient's effective electric defibrillation fast of chamber, saves patient's valuable life.
In the above-described embodiments, the contents such as the functional modules such as the physiological parameter such as electrocardio and the breast impedance acquisition module (5) of AED electric defibrillation device, human-computer interaction module (6), wireless communication module (7), high-voltage charging module (10), electrode (3), battery module (9) and drive circuit, electrocardio automatic analysis and identification, each module communication agreement and primary control program, the auxiliary rescue method of CPR are not contents of the present invention, elaborate therefore do not provide, specifically can realize with reference to correlation technique data and existing defibrillation Apparatus and system.