CN102961564B - Pharmaceutical composition for treating alcoholic cirrhosis - Google Patents
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Abstract
The invention discloses a pharmaceutical composition for treating alcoholic cirrhosis, aiming at solving the problem of treating the alcoholic cirrhosis. The pharmaceutical composition is characterized by processing a plurality of Chinese medicinal herbs in parts by weight according to the formula: 6-10 parts of crinite uraria herb, 8-15 parts of cotton tree bark, 8-15 parts of pennycress seed, 6-10 parts of rust-brown crotalaria, 6-10 parts of shiny-leaved birch bark, 8-15 parts of jasminum officinale, 6-10 parts of allium caeruleum, 1-3 parts of chalcanthite, and 3-6 parts of semen euryales. Proved by clinical trials, the pharmaceutical composition for treating alcoholic cirrhosis has the characteristics of being good in curative effect and higher in safety, and worthy of clinical application and popularization.
Description
Technical field
The present invention relates to the field of Chinese medicines, be specifically related to treat the pharmaceutical composition of alcoholic cirrhosis.
Background technology
Alcoholic cirrhosis is due to the liver cirrhosis due to long-term heavy drinking, is the end stage eventually of alcoholic liver disease, belongs to portal cirrhosis type.At China's sickness rate, obviously increase in recent years, account for 7% left and right of liver cirrhosis, be only second to liver cirrhosis after viral hepatitis.The pathogenic factor of alcoholic cirrhosis is: long-term excessive consumption of alcohol, particularly drink the wine of the high number of degrees, and cause hepatocyte steatosis, necrosis occur repeatedly and regenerate, finally cause liver cirrhosis.
Alcoholic cirrhosis generator is shaped with: 1. hepar damnification: drink and can cause liver ultrastructure damage, hepatic fibrosis and liver cirrhosis.2. immunoreation is disorderly: ethanol can activated lymphocyte, increases the pathogenic of B-mode, hepatitis C virus, increases the endotoxic hepatic injury toxicity that causes; The cytokines such as tumor necrosis factor during alcoholic hepatitis (TNF), interleukin (TL) increase; Ethanol and metabolite have a direct impact immunoregulation effect, can make immune marker change.3. collagenic supersession disorder and liver cirrhosis form: lipid peroxidation promotes collagen to form; The synthetic key enzyme proline hydroxylase of patients with alcoholic liver disease collagen is activated; Ethanol can make fat-storing cell become myofibroblast, and synthetic layer is mucoprotein, the mRNA content of collagen increases, synthetic various collagen; Ethanol contains ferrum, drinks and causes ferrum to be taken in and absorb increase, and in hepatocyte, ferrum granule is calm, and irony can stimulate fibroplasia, increases the weight of liver cirrhosis.
The Drug therapy of alcoholic cirrhosis mainly at present: protect the liver, fall enzyme, jaundice eliminating (as glucuronolatone, vitamin C), the medicine of oral reduction portal vein pressure (as propranolol, nitrate esters or calcium channel blocker), supplementary vitamin B group and digestive enzyme.In addition be symptomatic treatment, as the treatment of hypersplenism and ascites.But the medication effect of current clinical alcoholic cirrhosis is not remarkable, and some drugs liver metabolism increases the weight of burden of liver.
And Chinese medicine protects the liver, falls enzyme, jaundice eliminating effect certainly, treatment liver cirrhosis is started with from circulation of qi promoting, blood stasis dispelling, heat clearing away, dehumidifying mostly, but alcoholic cirrhosis is not identical with posthepatitic cirrhosis, there is not the pathologic basis of virus replication liver injury cell, and that steatosis, necrosis occur is repeatedly relevant with regeneration to hepatocyte, the hypersensitivity of hepatocyte to ethanol namely.So the prescription for the treatment of posthepatitic cirrhosis is for alcoholic cirrhosis effect not obvious.
Summary of the invention
Technical assignment of the present invention is for above the deficiencies in the prior art, and the pharmaceutical composition of the sure treatment alcoholic cirrhosis of a kind of curative effect is provided.
The technical scheme that the present invention solves its technical problem is: a kind of pharmaceutical composition for the treatment of alcoholic cirrhosis, it is characterized in that being processed by plurality of Chinese, its composition of raw materials and weight proportion are: 6 ~ 10 parts of Herba Urariae crinitae, 8 ~ 15 parts of 8 ~ 15 parts of ， Semen thlaspis of Cortex Gossampini, 6 ~ 10 parts of Herba Crotalariae Ferrugineaes, 6 ~ 10 parts of Cortex Betulae Luminiferaes, 8 ~ 15 parts of Flos jasmini, 6 ~ 10 parts of blue Jacob's ladders, 1 ~ 3 part, stone gallbladder, 3 ~ 6 parts of Semen Euryaless.
Its optimum weight proportioning is: 8 parts of Herba Urariae crinitae, 10 parts of 10 parts of ， Semen thlaspis of Cortex Gossampini, 8 parts of Herba Crotalariae Ferrugineaes, 8 parts of Cortex Betulae Luminiferaes, 10 parts of Flos jasmini, 8 parts of blue Jacob's ladders, 2 parts, stone gallbladder, 5 parts of Semen Euryaless.
Wherein said: Herba Urariae crinitae, for leguminous plant cat tail is penetrated the herb of Uraria crinita (T.) Desv..Nature and flavor are sweet; Micro-hardship; Flat.GUIXIN; Lung; Liver Channel.Merit can clearing away lung-heat to relieve cough; Dissipating blood stasis hemostasis.
Cortex Gossampini is the bark of Bombacaceae plant kapok.Sweet in the mouth; Light; Cool in nature.Return spleen; Liver; Large intestine channel.Merit can clearing away heat-damp and promoting diuresis; Removing toxic substances; Promoting blood circulation and detumescence.
Semen thlaspis, Cruciferae herba thlaspis genus plant Herba Thlaspis Thlaspi arvense L. seed.Nature and flavor are pungent, bitter, tepor.Expelling wind and removing dampness, and stomach and alleviating pain.
Herba Crotalariae Ferrugineae, for leguminous plant false herb or the whole herb with root of blue rotalaria ferruginea Grah..The bitter micro-acid of nature and flavor; Flat cold.Return lung meridian.Merit can nourishing the kidney and liver, relieving cough and asthma, eliminating damp, detoxifying.
Cortex Betulae Luminiferae is Betulaceae betula luminifera Betula luminifera H. Win Flos jasmini. bark.Nature and flavor are sweet; Pungent; Slightly warm in nature.Merit can damp eliminating cold expelling; Disappear stagnant and in, removing toxic substances.
Flos jasmini is Oleaceae plants Flos jasmini Jasminu, the dry flower of grandiflorum L..Property mildly bitter flavor; Property is put down.Return Liver Channel.Merit can soothing liver-QI for relieving depression, promoting the circulation of QI to relieve pain.
Blue Jacob's ladder, for the blue Jacob's ladder Allium of Liliaceae cyaneum Regel, with all herbal medicine.Nature and flavor are pungent, temperature.Merit can dispersing wind-cold, activates yang, and stomach invigorating.
Stone gallbladder is natural or made aqueous sulfuric acid copper crystalline solid.Sour, pungent, cold.Removing the necrotic tissue; Removing toxic substances.
Semen Euryales is the dry mature kernal of nymphaeaceae plant Gorgon euryale Euryale ferox Salisb..Nature and flavor are sweet, puckery, flat.Return spleen, kidney channel.Merit can supplementing the kidney to control the nocturnal, spleen reinforcing antidiarrheal, damp eliminating leukorrhagia stopping.
Composition principle: the rule for the treatment of that the Chinese medicine of alcoholic cirrhosis adopts clinically is now regulating qi to disperse stagnation removing damp-heat mostly, and inventor's clinical research for many years shows, but alcoholic cirrhosis is not identical with posthepatitic cirrhosis, there is not the pathologic basis of virus replication liver injury cell, and that steatosis, necrosis occur is repeatedly relevant with regeneration to hepatocyte, the hypersensitivity of hepatocyte to ethanol namely.So the prescription for the treatment of posthepatitic cirrhosis is for alcoholic cirrhosis effect not obvious.
The present invention compared with the prior art, has following characteristics.
1, with Herba Urariae crinitae, Cortex Gossampini He Semen thlaspis, coordinate: in Herba Urariae crinitae < < Chinese Pharmacopoeia > >, function cures mainly record " clearing away lung-heat to relieve cough in hurdle; Dissipating blood stasis hemostasis "; but inventor's clinical experience shows; and Herba Urariae crinitae is applied to alcoholic cirrhosis patient can recover rapidly liver function; coordinate the clearing away heat-damp and promoting diuresis of Cortex Gossampini; removing toxic substances is invigorated blood circulation, dehumidifying and the stomach and alleviating pain of Semen thlaspis; can effectively reduce the endotoxic hepatic injury toxicity that causes, the pharmacological results shows, Herba Urariae crinitae, Cortex Gossampini are with Semen thlaspis mixture decocting liquid can delay rat liver progression of fibrosis, and the successful of this combination is better than the stack of unit efficacy of drugs, the further research of still needing of its mechanism; And in we, do not select the medicine (as Radix Gentianae, Spica Prunellae, Ramulus Uncariae Cum Uncis, terrible sword plumage etc.) of removing heat from the liver, its reason is that alcoholic cirrhosis is not identical with posthepatitic cirrhosis, there is not the pathologic basis of virus replication liver injury cell, and steatosis, necrosis occur repeatedly and regenerate relevant to hepatocyte, the hypersensitivity of hepatocyte to ethanol namely, removing heat from the liver medicine is applied to alcoholic cirrhosis effect not obvious.
2, Herba Crotalariae Ferrugineae nourishing the kidney and liver, eliminating damp, detoxifying, a kind of medicine not only can have been got rid of evils but also can righting, so be best suited for the situation of alcoholic cirrhosis middle and late stage vital QI being weakened and pathogen being violent.
3, Flos jasmini soothing liver-QI for relieving depression, promoting the circulation of QI to relieve pain, this medicine does not have the dissipation characteristic of other the depressed liver-energy dispersing medicine (as Radix Bupleuri, Radix Curcumae etc.), is suitable for alcoholic cirrhosis patient and uses.
4, Cortex Betulae Luminiferae disappear stagnant and in, the stomach invigorating that activates yang of blue Jacob's ladder, inventor's research shows, adds this two herbal medicine can relieve portal hypertension symptom.
5, drink and cause ferrum to be taken in and absorb increase, in hepatocyte, ferrum granule is calm, and irony can stimulate fibroplasia, increases the weight of liver cirrhosis.Stone gallbladder is natural or made aqueous sulfuric acid copper crystalline solid, can reduce the absorption of body to ferrum element.
6, Semen Euryales supplementing the kidney to control the nocturnal, plays assistant and helps effect, gets the gesture of holding back, and can reduce ascites symptom and occur.
7, drug regimen raw material consumption of the present invention is groped in a large number to sum up through inventor and is drawn, each raw material consumption is for all to have good curative effect in following weight parts scope.
The specific embodiment
Below in conjunction with practical situation, the specific embodiment of the present invention is elaborated.
Embodiment 1, crude drug weight proportion: Herba Urariae crinitae 6g, Cortex Gossampini 8g ， Semen thlaspis 8g, Herba Crotalariae Ferrugineae 6g, Cortex Betulae Luminiferae 6g, Flos jasmini 8g, blue Jacob's ladder 6g, stone gallbladder 1g, Semen Euryales 3g.
Embodiment 2, crude drug weight proportion: Herba Urariae crinitae 10g, Cortex Gossampini 15g ， Semen thlaspis 15g, Herba Crotalariae Ferrugineae 10g, Cortex Betulae Luminiferae 10g, Flos jasmini 15g, blue Jacob's ladder 10g, stone gallbladder 3g, Semen Euryales 6g.
Embodiment 3, crude drug weight proportion: Herba Urariae crinitae 8g, Cortex Gossampini 10g ， Semen thlaspis 10g, Herba Crotalariae Ferrugineae 8g, Cortex Betulae Luminiferae 8g, Flos jasmini 10g, blue Jacob's ladder 8g, stone gallbladder 2g, Semen Euryales 5g.
During use, Chinese medicine Herba Urariae crinitae of the present invention, Cortex Gossampini, Semen thlaspis, Herba Crotalariae Ferrugineae, Cortex Betulae Luminiferae, Flos jasmini, blue Jacob's ladder, Semen Euryales and stone gallbladder are decocted with water to twice, after merging filtrate, a minute morning and evening takes.
Effective combination of aforementioned pharmaceutical compositions, coordinates mutually, can effectively reach the object for the treatment of alcoholic cirrhosis, and side effect is less.The above results is that clinical data fully proves, interrelated data is as follows, and wherein the use of drugs compositions is the crude drug weight proportion in embodiment 3.
1 object and method.
1.1 objects: be in January, 2010 ~ 2012 year JIUYUE alcoholic cirrhosis 64 examples, patient all meets alcoholic cirrhosis diagnostic criteria.Male 61 examples wherein, female's 3 examples, 26～59 years old age.Be divided at random treatment group 38 examples, matched group 26 examples, two groups of patients are at aspect comparing difference not statistically significants (P>0.05) such as age, sex, the courses of disease.MethodsThe cases enrolled all meets the diagnostic criteria of the alcoholic cirrhosis of in October, 2002 Nanjing meeting formulation, MethodsThe cases enrolled all has clear and definite history of drinking history > 5 years, amount to amount of alcohol > 40g/d (women >=20g/d), all there is clinically the performance of hypofunction of liver and portal hypertension, get rid of HBV, HCV infection and metabolic, Drug, autoimmune liver disease.
1.2 methods: two groups of cases are all advised its teetotalism, the matched group treatments such as mixture, propranolol, mattress Cape jasmine Huang and vitamin C of energizing, treatment group gives the medicine composite for curing of the embodiment of the present invention 3 gained.During treatment, observe the symptoms and sign every day: weak, hepatalgia, abdominal distention, loss of appetite and hepatomegaly.Measure weekly liver function ALT, AST, GGT and TBIL.
1.3 safety evaluatio: all carry out blood, urine, stool routine before and after medication, renal function detects.
1.4 statistical analysis: carry out statistical analysis with SPSS 13.0, P<0.05 indicates significant.
2 results.
2.1 symptoms and sign are improved situation: treat after 2 weeks, treatment group is weak, the improvement of hepatalgia, abdominal distention and loss of appetite symptom is obviously better than matched group (P<0.05), compare P<0.05 simultaneously with before treatment, and portal hypertension index at two group differences without significance; The recovery for the treatment of 4 weeks treatment group portal hypertension indexs with before treatment, compare difference and have significance (P<0.05), be also obviously better than matched group P<0.05 simultaneously.Weak, the hepatalgia for the treatment of group, abdominal distention, loss of appetite are compared P<0.05 with matched group, and compare P<0.05 before treatment.
2.2 biochemical indicators improve situations: treat after 2 weeks treatment group ALT, AST and treat front difference and have significance (P<0.05), the while is obviously better than matched group (P<0.05).Treatment group GGT and TBIL are without significant change (P > 0.05), treat after 4 weeks, 4 biochemical indicators for the treatment of group are all obviously better than matched group (P<0.05), ALT, AST compare P<0.01 with before treatment, and GGT, TBIL compare P<0.05 with before treatment.
2.2 untoward reaction: treatment group has 2 examples to occur heating, erythra, does not affect treatment after anti symptom treatment, and 38 routine patients all can tolerate treatment.
3. conclusion.
This result of study prompting, the present invention treats alcoholic cirrhosis and has good effect, the feature that rapid-action and safety is higher, clinic application, promotes.
Claims (2)
1. a pharmaceutical composition for the treatment of alcoholic cirrhosis, it is characterized in that being processed by plurality of Chinese, its composition of raw materials and weight proportion are: 6 ~ 10 parts of Herba Urariae crinitae, 8 ~ 15 parts of 8 ~ 15 parts of ， Semen thlaspis of Cortex Gossampini, 6 ~ 10 parts of Herba Crotalariae Ferrugineaes, 6 ~ 10 parts of Cortex Betulae Luminiferaes, 8 ~ 15 parts of Flos jasmini, 6 ~ 10 parts of blue Jacob's ladders, 1 ~ 3 part, Chalcanthitum, 3 ~ 6 parts of Semen Euryaless.
2. a kind of pharmaceutical composition for the treatment of alcoholic cirrhosis according to claim 1, is characterized in that its weight proportion is: 8 parts of Herba Urariae crinitae, 10 parts of 10 parts of ， Semen thlaspis of Cortex Gossampini, 8 parts of Herba Crotalariae Ferrugineaes, 8 parts of Cortex Betulae Luminiferaes, 10 parts of Flos jasmini, 8 parts of blue Jacob's ladders, 2 parts, Chalcanthitum, 5 parts of Semen Euryaless.
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| CN201210543322.1A CN102961564B (en) | 2012-12-16 | 2012-12-16 | Pharmaceutical composition for treating alcoholic cirrhosis |
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| CN201210543322.1A CN102961564B (en) | 2012-12-16 | 2012-12-16 | Pharmaceutical composition for treating alcoholic cirrhosis |
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