CN102935178B - Chinese medicine preparation for treating cerebral arteriosclerosis - Google Patents
Chinese medicine preparation for treating cerebral arteriosclerosis Download PDFInfo
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- CN102935178B CN102935178B CN201210459441.9A CN201210459441A CN102935178B CN 102935178 B CN102935178 B CN 102935178B CN 201210459441 A CN201210459441 A CN 201210459441A CN 102935178 B CN102935178 B CN 102935178B
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Abstract
本发明提供了一种治疗脑动脉硬化的中药制剂，其主要是由下列的原料药制成的：杞果、山茱萸、石斛、当归、天麻、制首乌、怀牛膝、焦术、丹参、焦山楂、炒卜子、半夏、橘红、云苓、三七参、炒远志，将这些药物组合使得各药物功效产生协同作用，从而有效地培补肝肾、调理脾胃、活血化瘀、涤痰醒脑。与现有技术相比，本发明具有简、便、验、廉、副作用小、标本兼治，患者易于接受，能够更为有效治疗脑动脉硬化的优点，值得临床推广应用。The invention provides a traditional Chinese medicine preparation for treating cerebral arteriosclerosis, which is mainly made of the following raw materials: Qiguo, Cornus officinalis, Dendrobium, Angelica, Gastrodia elata, Zhishouwu, Achyranthes bidentata, Jiaozhu, Danshen, Burnt hawthorn, fried radish, pinellia, orange red, Yunling, notoginseng, fried polygala, the combination of these drugs makes the effects of each drug produce a synergistic effect, thereby effectively nourishing the liver and kidney, regulating the spleen and stomach, promoting blood circulation and removing blood stasis, cleaning Phlegm refreshes the brain. Compared with the prior art, the present invention has the advantages of being simple, convenient, reliable, inexpensive, has few side effects, treats both symptoms and root causes, is easily accepted by patients, and can more effectively treat cerebral arteriosclerosis, and is worthy of clinical popularization and application.
Description
Technical field
The invention belongs to technical field of Chinese medicines, be specifically related to a kind of Chinese medicine preparation for the treatment of cerebral arteriosclerosis.
Background technology
Cerebral arteriosclerosis is more common in 40 years old above male and the women in menopause, main change is steatosis and the cholesterol deposits of endarterium deep layer, form atherosclerotic plaque and various secondary affection, make tube chamber spasm, narrow, even inaccessible, then cause a series of neuropsychiatric disorders.May be closely related with factors such as age, hypertension, hyperlipidemia, diabetes, obesities, it is multifactor, the interactional complex process of too many levels, the wherein too high or metabolism disorder of vascular endothelial injury, vascular smooth muscle cell curing, blood lipid level, platelet activation, gathering etc. play an important role in arteriosclerosis evolution, but its exact cause is not yet illustrated.Thereby bring certain difficulty to treatment, and what specific medicament is doctor trained in Western medicine there is no, and just gives blood fat reducing, expands blood vessel, improves brain blood circulation, improves the treatments such as brain metabolism for symptom, and uncertain therapeutic efficacy is fixed, and easily recurrence.Cerebral arteriosclerosis belongs to the dizzy category of motherland's medical science, due to people in middle age, Liver and kidney is mainly with loss, in addition large, the long-term psychentonia of operating pressure, stay up late etc., daily life accidentally or innate deficiency, cause Liver and kidney more empty exhausted, wind is from interior life, the horizontal gram spleen soil of wind wood, insufficiency of the spleen mistake in building fortune, water retention is wet, wet consor expectorant, and with the passing of time the stagnation of phlegm stasis of blood is raw, hoodwink clearly key and fall ill, so treatment primary disease, should develop the characteristic of traditional Chinese medical science organic conception, treatment must aim at the pathogenesis of disease, adopt the method for nourishing liver and kidney, function of spleen and stomach regulating, blood circulation promoting and blood stasis dispelling, clearing away phlegm refreshment.
Summary of the invention
Therefore still there is demand to the Chinese medicine preparation of curative effect better healing cerebral arteriosclerosis in the mankind, up to now, also do not find any report about pharmaceutical composition of the present invention, the inventor is through research repeatedly, finally the Chinese medicine preparation that has found the treatment cerebral arteriosclerosis of better efficacy, has completed the present invention.The object of the invention is to provide that a kind of side effect is little, treating both the principal and secondary aspects of a disease, can more effectively treat the Chinese medicine preparation of cerebral arteriosclerosis.
The consumption of ingredients part of the present invention is that inventor gets through groping in a large number for a long time to sum up, and each component consumption all has good curative effect in following weight parts:
30～90 parts of fructus lyciis, 30～90 parts of Fructus Corni, 30～90 parts of Herba Dendrobiis, 18～54 parts of Radix Angelicae Sinensis, 18～54 parts, Rhizoma Gastrodiae, 18～54 parts of Radix Polygoni Multiflori Preparata, 18～54 parts of Radix Achyranthis Bidentataes, 18～54 parts of Rhizoma Atractylodis Macrocephalae, 18～54 parts of Radix Salviae Miltiorrhizaes, 18～54 parts of Fructus Crataegi (parched to brown)s, 18～54 parts of BUZI of stir-fry, 12～36 parts of the Rhizoma Pinelliaes, 12～36 parts of Exocarpium Citri Rubrums, 12～36 parts of Poria, 12～36 parts of Radix Notoginseng, 12～36 parts of Radix Polygalae (parched).
Medicament selection fructus lycii of the present invention, Fructus Corni, Herba Dendrobii, Radix Angelicae Sinensis, Rhizoma Gastrodiae, Radix Polygoni Multiflori Preparata, Radix Achyranthis Bidentatae, Rhizoma Atractylodis Macrocephalae, Radix Salviae Miltiorrhizae, Fructus Crataegi (parched to brown), stir-fry BUZI, the Rhizoma Pinelliae, Exocarpium Citri Rubrum, Poria, Radix Notoginseng, Radix Polygalae (parched) combine, make each efficacy of drugs produce synergism these drug regimens, thus nourishing liver and kidney, function of spleen and stomach regulating, blood circulation promoting and blood stasis dispelling, clearing away phlegm refreshment effectively.In the present invention with fructus lycii, Rhizoma Dioscoreae, Herba Dendrobii, Radix Polygoni Multiflori Preparata, nourishing liver and kidney taking Zhi Qiben as monarch, Poria, Rhizoma Atractylodis Macrocephalae, burnt short, bristly hair or beard, fry BUZI, function of spleen and stomach regulating is minister, Radix Angelicae Sinensis, Radix Salviae Miltiorrhizae, Radix Achyranthis Bidentatae, the Rhizoma Pinelliae, Exocarpium Citri Rubrum, Radix Notoginseng clearing away phlegm and removing blood stasis are controlled its mark.Rhizoma Gastrodiae endogenous wind stopping relieving convulsion, suppressing the hyperactive liver and subsiding YANG, dispelling wind and removing obstruction in the collateral." book on Chinese herbal medicine is newly organized " cloud: Rhizoma Gastrodiae, can be only giddy, treat wind and dry, control muscles and bones contracture paralysis, promoting blood circulation, has one's ideas straightened out.Modern pharmacological research Radix Salviae Miltiorrhizae has regulating blood lipid action; Fructus Crataegi has the atherosclerotic effect of disappearing; Radix Angelicae Sinensis has anticoagulant effect; Radix Polygoni Multiflori Preparata has and alleviates arteriosclerotic effect; Rhizoma Gastrodiae can increase cerebral blood flow, reduces cerebral vascular resistance, slightly shrinks cerebrovascular, increases coronary vasodilator flow.All medicine compatibilities, monarch, the merit of nourishing liver and kidney, function of spleen and stomach regulating, blood circulation promoting and blood stasis dispelling, clearing away phlegm refreshment is played in coordination altogether mutually.Take a broad view of full side, treating both the principal and secondary aspects of a disease, reinforcement and elimination in combination, heresy is gone and is not just hindered, righting and do not help heresy.Compared with prior art, the present invention have letter, just, test, honest and clean, side effect is little, treating both the principal and secondary aspects of a disease, patient is easy to accept, and can more effectively treat the advantage of cerebral arteriosclerosis, clinic is applied.
Detailed description of the invention
The Chinese medicine preparation for the treatment of cerebral arteriosclerosis of the present invention is to be made up of the crude drug of following weight portion:
30～90 parts of fructus lyciis, 30～90 parts of Fructus Corni, 30～90 parts of Herba Dendrobiis, 18～54 parts of Radix Angelicae Sinensis, 18～54 parts, Rhizoma Gastrodiae, 18～54 parts of Radix Polygoni Multiflori Preparata, 18～54 parts of Radix Achyranthis Bidentataes, 18～54 parts of Rhizoma Atractylodis Macrocephalae, 18～54 parts of Radix Salviae Miltiorrhizaes, 18～54 parts of Fructus Crataegi (parched to brown)s, 18～54 parts of BUZI of stir-fry, 12～36 parts of the Rhizoma Pinelliaes, 12～36 parts of Exocarpium Citri Rubrums, 12～36 parts of Poria, 12～36 parts of Radix Notoginseng, 12～36 parts of Radix Polygalae (parched).
The present invention takes according to said medicine weight proportion, mixes, pulverizes, sieves, sterilizing, and the general ball that is made as of wine is as large in Firmiana simplex seed; The present invention can also take according to said medicine weight proportion, mixes, pulverizes, sieves, sterilizing, makes capsule.
Medicine major function of the present invention and therapeutic domain
1, major function:
Nourishing liver and kidney, function of spleen and stomach regulating, blood circulation promoting and blood stasis dispelling, clearing away phlegm refreshment.
2, therapeutic domain:
Be applicable to cerebral arteriosclerosis and due to headache, disease, hyperlipemia, the obesity such as dizzy.
3, usage and consumption
Each 1.5g, every day 3 times, 15 days is a course for the treatment of, one week, interval between two courses for the treatment of.Period in a medicine avoids eating anything raw or cold, pungent greasy.
Further set forth the beneficial effect of the Chinese medicine preparation for the treatment of cerebral arteriosclerosis of the present invention below by test example, these test examples comprise the clinical observation on the therapeutic effect test of the Chinese medicine preparation for the treatment of cerebral arteriosclerosis of the present invention.
[
test example] clinical observation of Chinese medicine preparation for the treatment of cerebral arteriosclerosis of the present invention
1, physical data
Accept out-patient's 181 examples for medical treatment, patient is divided into two groups at random, treatment group 151 examples, give Drug therapy of the present invention, wherein male 102 examples, female's 49 examples; Minimum 40 years old of age, maximum 71 years old; The state of an illness belongs to severe person's 35 examples, moderate 56 examples, slight 60 examples.Check wherein internal carotid artery 8 examples of hardening, middle cerebral artery 45 examples of hardening, vertebra basilar artery 14 examples of hardening through rheoencephalogram or TCD.Matched group 30 examples, giving oneself has Drug therapy, male 21 examples, female's 9 examples; Minimum 41 years old of age, maximum 70 years old; The state of an illness belongs to severe person's 4 examples, moderate 10 examples, and slight 16 examples, check through rheoencephalogram or TCD, wherein internal carotid artery 2 examples of hardening, middle cerebral artery 9 examples of hardening, vertebra basilar artery 3 examples of hardening.Two groups of patients learn processing by statistics at aspects such as sex, age, the course of disease, state of an illness weight and Clinical symptoms, have balanced comparability (t inspection, P value <0.5).
2, diagnostic criteria
The card Standardization of diagnosis and curative effect of curing the desease among People's Republic of China's Chinese medicine industry standard that all cases is issued with reference to State Administration of Traditional Chinese Medicine is determined diagnosis.
3, Therapeutic Method
Therapeutic Method is under the voluntary prerequisite of patient, patient is divided into two groups at random, and treatment group 151 examples, take Drug therapy of the present invention, each 1.5g every day three times, oral, within 15 days, is a course for the treatment of, and drug withdrawal is taken next course for the treatment of for one week again, takes for 4 courses for the treatment of; Matched group 70 examples, taking oneself has Drug therapy, every day 2-3 time, takes for 4 courses for the treatment of.
4, efficacy assessment standard
Cure: symptom, sign and test chamber inspection are normal.
Effective: sings and symptoms is normal, relevant lab testing is improved.
Take a turn for the better: sings and symptoms alleviates, and lab testing is improved.
Do not heal: symptom is without improvement.
5. results and analysis (in table 1)
Table 1 liang group curative effect comparison
Treatment group curative effect is obviously better than matched group as can be seen from Table 1, and its total effective rate (95.4%) is apparently higher than matched group (76.67%).
model case:
Example 1. Caos, female, 55 years old, area just outside a city gate town, Zhenping County Cao Ying people from village.First visit on February 20 in 2003.Readme is interrupted headache, dizzy 2 years, time have tinnitus, measuring blood pressure 120/80mmHg, checks through TCD: prompting: 1. cerebral arteries compliance decline, 2. bilateral vertebral-basilar artery spasm, is diagnosed as 1. cerebral arteriosclerosis 2. cerebral vasospasms; Give drug oral of the present invention and treated for four courses for the treatment of, headache alleviates, and two courses for the treatment of of following the service, symptom and sign disappears, and follows up a case by regular visits to and within 3 years, has no recurrence.
Example 2. Liu, female, 60 years old, Guan Luhe people from village, Zhenping County.On February 16th, 2004 is medical.Patient's dizziness, headache, nape pain, left upper extremity numbness, two weakness of the lower extremities are seemingly stepped on Cotton Gossypii sense more than 2 years, and when severe symptoms, dizziness and tinnitus can not be got up, measuring blood pressure 130/80mmHg; TCD shows: right side anterior cerebral artery and left vertebral artery flow velocity slow down, diagnosis: 1. cerebral arteriosclerosis, 2. cervical spondylosis.After taking five courses for the treatment of of medicine of the present invention, symptom and sign is eliminated, and follows up a case by regular visits to not recurrence in 2 years.
Example 3. Wus, man, 65 years old, Wolong District, Nanyang.The medical date: on February 5th, 2004.Patient is unknown cause dizziness before 1 year, dizzy heavy, hypomnesis, insomnia, measuring blood pressure 130/90mmHg, blood fat is slightly high, TCD checks: two brains and posterior cerebral artery blood flow rate are symmetrical, and flow velocity is slow. bilateral vertebral artery blood flow rate left-right asymmetry, left side flow velocity is slow.Diagnosis: 1. cerebral arteriosclerosis, 2. cervical spondylosis.Give dizzy transference cure after four courses for the treatment of of Drug therapy of the present invention, following the service clinical cure four courses for the treatment of.2 years patients there is not recurrence work and live as usual in outpatient service check.
Example 4. Lee, female, 45 years old, end of the bridge people from town, Sheqi County of Henan Province, on February 11st, 2003 is medical.Patient's dizziness, headache, nape pain, two weakness of the lower extremities more than 2 years, heavy when light when symptom, when severe symptoms dizziness and tinnitus can not get up, moving nausea and vomiting, measuring blood pressure 130/80mmHg, blood fat is normal.TCD shows: the two vertebral arteries of middle cerebral artery speed, end stream noise.Diagnosis: cerebral vasospasm.After taking two courses for the treatment of of medicine of the present invention, all cards alleviate, following the service clinical cure four courses for the treatment of.Follow up a case by regular visits to not recurrence in 2 years.
When example 5., female, 40 years old, Wolong District, Nanyang people from Xie village, on the medical date: on February 8th, 2002, patient states headache, dizziness, have a rest when bad and increase the weight of, nose heave unconsciousness, take Western medicine in Duo Jia hospital, time heavy when light, measuring blood pressure 130/80mmHg, blood fat, blood glucose are normal, TCD checks: right side anterior cerebral artery and two vertebral artery compliance reduce, and blood flow speeds, diagnosis: cerebral vasospasm.Take after four courses for the treatment of of medicine of the present invention remission, following the service clinical cure four courses for the treatment of.1 year state of an illness of clinical check is basicly stable.
Example 6. what certain, female, 60 years old, Wancheng District, Nanyang, on October 12nd, 2002 is medical; Readme dizziness, dizzy heavy, hypomnesis, insomnia, time have a dizziness.Measuring blood pressure 140/86mmHg, blood fat, blood glucose are normal, and TCD checks: left anterior cerebral artery blood flow is slack-off.Diagnosis: 1. cerebral arteriosclerosis.After four courses for the treatment of of drug administration of the present invention, all diseases alleviate, following the service clinical being almost recovered two courses for the treatment of, follow up a case by regular visits to 3 years basicly stable.
Example 7. Zhao, female, 45 years old, Tanghe County, Henan Province Ma Zhen hold up village people.The medical date: on March 2nd, 2003; Patient's dizziness, headache, nape pain, two weakness of the lower extremities more than 2 years, when severe symptoms dizziness and tinnitus can not get up, moving nausea and vomiting, measuring blood pressure 120/80mmHg, blood fat is normal.TCD shows: blood flow of middle cerebral artery speeds, end stream noise.Diagnosis: 1. cerebral vasospasm.Oral medicine of the present invention patient's symptom and sign one course for the treatment of disappears and follows up a case by regular visits to not recurrence in a year.
Example 8. Lee, man, 52 years old, the new shop village people in Nanyang.The medical date: on October 23rd, 2002; Patient is the year before because of tired dizzy, dizzy heavy, hypomnesis, and insomnia, measuring blood pressure 130/90mmHg, TCD checks and shows: right side anterior cerebral artery and left vertebral artery flow velocity slow down.Diagnosis: cerebral arteriosclerosis.After taking three courses for the treatment of of medicine of the present invention, all cards alleviate, following the service clinical cure four courses for the treatment of.Advise and continue medication until recovery from illness.Follow up a case by regular visits to not recurrence in 2 years.
Example 9. Huangs, female, 42 years old, area just outside a city gate people from town, Tongbo County, Henan Province.On July 29th, 2004 is medical; Patient's readme dizziness, dizzy heavy, hypomnesis, insomnia, measuring blood pressure 130/90mmHg.The two vertebral arteries of TCD report middle cerebral artery speed.Oral medicine of the present invention headache three courses for the treatment of, dizziness alleviate, and following the service all cards four courses for the treatment of remove entirely, clinical cure.
Example 10. is thanked certain, man, 61 years old, Tanghe County, Henan Province king collect village people.The medical date: on February 13rd, 2004.Patient's dizziness, dizzy heavy, hypomnesis, insomnia, measuring blood pressure 130/90mmHg, TCD checks and shows: right anterior cerebral artery blood flow slows down.Diagnosis: cerebral arteriosclerosis.Use medicine all cards two courses for the treatment of of the present invention to have and subtract, following the service clinical cure four courses for the treatment of.Follow-up shows no obvious abnormalities for 1 year.
Further illustrate the Chinese medicine preparation for the treatment of cerebral arteriosclerosis of the present invention below by embodiment.
embodiment 1:
The Chinese medicine preparation for the treatment of cerebral arteriosclerosis of the present invention is to be made up of the crude drug of following weight portion:
30 parts of fructus lyciis, 30 parts of Fructus Corni, 30 parts of Herba Dendrobiis, 18 parts of Radix Angelicae Sinensis, 18 parts, Rhizoma Gastrodiae, 18 parts of Radix Polygoni Multiflori Preparata, 18 parts of Radix Achyranthis Bidentataes, 18 parts of Rhizoma Atractylodis Macrocephalae, 18 parts of Radix Salviae Miltiorrhizaes, 18 parts of Fructus Crataegi (parched to brown)s, 18 parts of BUZI of stir-fry, 12 parts of the Rhizoma Pinelliaes, 12 parts of Exocarpium Citri Rubrums, 12 parts of Poria, 12 parts of Radix Notoginseng, 12 parts of Radix Polygalae (parched).
embodiment 2:
The Chinese medicine preparation for the treatment of cerebral arteriosclerosis of the present invention is to be made up of the crude drug of following weight portion:
45 parts of fructus lyciis, 45 parts of Fructus Corni, 45 parts of Herba Dendrobiis, 27 parts of Radix Angelicae Sinensis, 27 parts, Rhizoma Gastrodiae, 27 parts of Radix Polygoni Multiflori Preparata, 27 parts of Radix Achyranthis Bidentataes, 27 parts of Rhizoma Atractylodis Macrocephalae, 27 parts of Radix Salviae Miltiorrhizaes, 27 parts of Fructus Crataegi (parched to brown)s, 27 parts of BUZI of stir-fry, 18 parts of the Rhizoma Pinelliaes, 18 parts of Exocarpium Citri Rubrums, 18 parts of Poria, 18 parts of Radix Notoginseng, 18 parts of Radix Polygalae (parched).
embodiment 3:
The Chinese medicine preparation for the treatment of cerebral arteriosclerosis of the present invention is to be made up of the crude drug of following weight portion:
60 parts of fructus lyciis, 60 parts of Fructus Corni, 60 parts of Herba Dendrobiis, 36 parts of Radix Angelicae Sinensis, 36 parts, Rhizoma Gastrodiae, 36 parts of Radix Polygoni Multiflori Preparata, 36 parts of Radix Achyranthis Bidentataes, 36 parts of Rhizoma Atractylodis Macrocephalae, 36 parts of Radix Salviae Miltiorrhizaes, 36 parts of Fructus Crataegi (parched to brown)s, 36 parts of BUZI of stir-fry, 24 parts of the Rhizoma Pinelliaes, 24 parts of Exocarpium Citri Rubrums, 24 parts of Poria, 24 parts of Radix Notoginseng, 24 parts of Radix Polygalae (parched).
embodiment 4:
The Chinese medicine preparation for the treatment of cerebral arteriosclerosis of the present invention is to be made up of the crude drug of following weight portion:
75 parts of fructus lyciis, 75 parts of Fructus Corni, 75 parts of Herba Dendrobiis, 45 parts of Radix Angelicae Sinensis, 45 parts, Rhizoma Gastrodiae, 45 parts of Radix Polygoni Multiflori Preparata, 45 parts of Radix Achyranthis Bidentataes, 45 parts of Rhizoma Atractylodis Macrocephalae, 45 parts of Radix Salviae Miltiorrhizaes, 45 parts of Fructus Crataegi (parched to brown)s, 45 parts of BUZI of stir-fry, 30 parts of the Rhizoma Pinelliaes, 30 parts of Exocarpium Citri Rubrums, 30 parts of Poria, 30 parts of Radix Notoginseng, 30 parts of Radix Polygalae (parched).
embodiment 5:
The Chinese medicine preparation for the treatment of cerebral arteriosclerosis of the present invention is to be made up of the crude drug of following weight portion:
90 parts of fructus lyciis, 90 parts of Fructus Corni, 90 parts of Herba Dendrobiis, 54 parts of Radix Angelicae Sinensis, 54 parts, Rhizoma Gastrodiae, 54 parts of Radix Polygoni Multiflori Preparata, 54 parts of Radix Achyranthis Bidentataes, 54 parts of Rhizoma Atractylodis Macrocephalae, 54 parts of Radix Salviae Miltiorrhizaes, 54 parts of Fructus Crataegi (parched to brown)s, 54 parts of BUZI of stir-fry, 36 parts of the Rhizoma Pinelliaes, 36 parts of Exocarpium Citri Rubrums, 36 parts of Poria, 36 parts of Radix Notoginseng, 36 parts of Radix Polygalae (parched).
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| CN1124153C (en) * | 2001-08-31 | 2003-10-15 | 石家庄以岭药业股份有限公司 | Medicinal composition for restoring cardiac collaterals and its application |
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Inventor after: Tang Xuemin Inventor after: Ding Jishan Inventor after: Cheng Lin Inventor after: Yang Shuhui Inventor after: Liu Yinwei Inventor after: Cai Yongmin Inventor after: Wei Xiaomeng Inventor before: Tang Xuemin Inventor before: Ding Jishan Inventor before: Yuan Min Inventor before: Cheng Lin Inventor before: Yang Shuhui Inventor before: Cai Yongmin Inventor before: Wei Xiaomeng |
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Free format text: CORRECT: INVENTOR; FROM: TANG XUEMIN DING JISHAN YUAN MIN CHENG LIN YANG SHUHUI CAI YONGMIN WEI XIAOMENG TO: TANG XUEMIN DING JISHAN CHENG LIN YANG SHUHUI LIU YINWEI CAI YONGMIN WEI XIAOMENG |
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