CN102925064A - Interventional anti-infective water-based adhesive - Google Patents
Interventional anti-infective water-based adhesive Download PDFInfo
- Publication number
- CN102925064A CN102925064A CN2012104124216A CN201210412421A CN102925064A CN 102925064 A CN102925064 A CN 102925064A CN 2012104124216 A CN2012104124216 A CN 2012104124216A CN 201210412421 A CN201210412421 A CN 201210412421A CN 102925064 A CN102925064 A CN 102925064A
- Authority
- CN
- China
- Prior art keywords
- parts
- infective
- interventional
- water
- based adhesive
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 230000002924 anti-infective effect Effects 0.000 title claims abstract description 14
- 239000000853 adhesive Substances 0.000 title claims abstract description 13
- 230000001070 adhesive effect Effects 0.000 title claims abstract description 13
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 title abstract 3
- 229920001651 Cyanoacrylate Polymers 0.000 claims abstract description 8
- 229920000193 polymethacrylate Polymers 0.000 claims abstract description 8
- GHMLBKRAJCXXBS-UHFFFAOYSA-N resorcinol Chemical compound OC1=CC=CC(O)=C1 GHMLBKRAJCXXBS-UHFFFAOYSA-N 0.000 claims description 14
- NWXMGUDVXFXRIG-WESIUVDSSA-N (4s,4as,5as,6s,12ar)-4-(dimethylamino)-1,6,10,11,12a-pentahydroxy-6-methyl-3,12-dioxo-4,4a,5,5a-tetrahydrotetracene-2-carboxamide Chemical compound C1=CC=C2[C@](O)(C)[C@H]3C[C@H]4[C@H](N(C)C)C(=O)C(C(N)=O)=C(O)[C@@]4(O)C(=O)C3=C(O)C2=C1O NWXMGUDVXFXRIG-WESIUVDSSA-N 0.000 claims description 7
- 230000000694 effects Effects 0.000 abstract description 4
- 206010061218 Inflammation Diseases 0.000 abstract description 2
- 208000015181 infectious disease Diseases 0.000 abstract description 2
- 230000004054 inflammatory process Effects 0.000 abstract description 2
- 239000002904 solvent Substances 0.000 abstract description 2
- QIGBRXMKCJKVMJ-UHFFFAOYSA-N Hydroquinone Chemical compound OC1=CC=C(O)C=C1 QIGBRXMKCJKVMJ-UHFFFAOYSA-N 0.000 abstract 2
- RAHZWNYVWXNFOC-UHFFFAOYSA-N Sulphur dioxide Chemical compound O=S=O RAHZWNYVWXNFOC-UHFFFAOYSA-N 0.000 abstract 2
- KPQZUUQMTUIKBP-UHFFFAOYSA-N 1-(2-methyl-5-nitro-1-imidazolyl)-2-propanol Chemical compound CC(O)CN1C(C)=NC=C1[N+]([O-])=O KPQZUUQMTUIKBP-UHFFFAOYSA-N 0.000 abstract 1
- 239000004098 Tetracycline Substances 0.000 abstract 1
- 230000003467 diminishing effect Effects 0.000 abstract 1
- -1 n-octyl Chemical group 0.000 abstract 1
- 229960004076 secnidazole Drugs 0.000 abstract 1
- 229960002180 tetracycline Drugs 0.000 abstract 1
- 229930101283 tetracycline Natural products 0.000 abstract 1
- 235000019364 tetracycline Nutrition 0.000 abstract 1
- 150000003522 tetracyclines Chemical class 0.000 abstract 1
- 239000000463 material Substances 0.000 description 2
- 230000002980 postoperative effect Effects 0.000 description 2
- 208000007536 Thrombosis Diseases 0.000 description 1
- 238000004026 adhesive bonding Methods 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- 239000003292 glue Substances 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 210000003101 oviduct Anatomy 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 238000004513 sizing Methods 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
Landscapes
- Materials For Medical Uses (AREA)
- Adhesives Or Adhesive Processes (AREA)
Abstract
The invention discloses an interventional anti-infective water-based adhesive which comprises the following components in parts by weight: 100 parts of n-octyl a-cyanoacrylate, 10-15 parts of polymethacrylate, 4-10 parts of tetracycline, 2-6 parts of secnidazole, 0.2-0.5 part of hydroquinone and 0.05-0.2 part of sulfur dioxide. The interventional anti-infective water-based adhesive disclosed by the invention enables the human body tissues to be easy for binding in an anaerobic and solvent environment, has counter force against anaerobes, can effectively relieve the infection of the human body tissues in or after operation, and has the function of diminishing inflammation, thereby ensuring the binding effect of the human body tissues.
Description
Technical field
The present invention relates to the gluing material of polymer, belong to Material Field.
Background technology
The sizing agent of intervener body tissue mainly is comprised of a-BCA and sulfurous gas etc. at present.This glue can powerfully bind when injected organism tissue, and bonding speed is rapid, and is nontoxic, little to tissue reaction, can not cause thrombus, can simply sterilize.Be usually used in the bonding to the in-vivo tissue such as uterine tube, liver, stomach be dirty.Owing to can produce the tissue of getting involved in when operation and to destroy, if be organized in the art or postoperative infects or inflammation in a short time, be easy to affect the effect of bonding, cause operative failure.
Summary of the invention
The technical problem to be solved in the present invention is to overcome existing defective, provides a kind of Interventional anti-infective, antibiotic, that cohesive force is strong anti-infective aqueous adhesive.
Purpose of the present invention is come specific implementation by the following technical programs:
The anti-infective aqueous adhesive of a kind of Interventional, each component by weight, 100 parts of a-alpha-cyanoacrylate n-octyls, polymethacrylate 10-15 part, tsiklomitsin 4-10 part, Saikexiaozuo 2-6 part, Resorcinol 0.2-0.5 part, sulfurous gas 0.05-0.2 part.
As preferred version, the anti-infective aqueous adhesive of above-mentioned Interventional, each component by weight, 100 parts of a-alpha-cyanoacrylate n-octyls, 13.5 parts of polymethacrylate, 10 parts in tsiklomitsin, 5 parts of Saikexiaozuos, 0.2 part of Resorcinol, 0.05 part of sulfurous gas.
Beneficial effect of the present invention:
The anti-infective aqueous adhesive of Interventional provided by the present invention, make tissue under anaerobism and solvent environment, be easy to bonding, and have the strong resistance of anerobe, can effectively alleviate in the art or the infection of postoperative tissue, effect with anti-inflammatory is from having guaranteed the bond effect of tissue.
Embodiment
Below the preferred embodiments of the present invention are described, should be appreciated that preferred embodiment described herein only is used for description and interpretation the present invention, is not intended to limit the present invention.
Embodiment 1:
The anti-infective aqueous adhesive of a kind of Interventional, each component by weight, 100 parts of a-alpha-cyanoacrylate n-octyls, 13.5 parts of polymethacrylate, 10 parts in tsiklomitsin, 5 parts of Saikexiaozuos, 0.2 part of Resorcinol, 0.05 part of sulfurous gas.
Embodiment 2:
The anti-infective aqueous adhesive of a kind of Interventional, each component by weight, 100 parts of a-alpha-cyanoacrylate n-octyls, 10 parts of polymethacrylate, 4 parts in tsiklomitsin, 2 parts of Saikexiaozuos, 0.2 part of Resorcinol, 0.05 part of sulfurous gas.
Embodiment 3:
The anti-infective aqueous adhesive of a kind of Interventional, each component by weight, 100 parts of a-alpha-cyanoacrylate n-octyls, 15 parts of polymethacrylate, 10 parts in tsiklomitsin, 6 parts of Saikexiaozuos, 0.5 part of Resorcinol, 0.2 part of sulfurous gas.
The above only is the preferred embodiments of the present invention, be not limited to the present invention, although with reference to previous embodiment the present invention is had been described in detail, for a person skilled in the art, it still can be made amendment to the technical scheme that aforementioned each embodiment puts down in writing, and perhaps part technical characterictic wherein is equal to replacement.Within the spirit and principles in the present invention all, any modification of doing, be equal to replacement, improvement etc., all should be included within protection scope of the present invention.
Claims (2)
1. anti-infective aqueous adhesive of Interventional, it is characterized in that: each component by weight, 100 parts of a-alpha-cyanoacrylate n-octyls, polymethacrylate 10-15 part, tsiklomitsin 4-10 part, Saikexiaozuo 2-6 part, Resorcinol 0.2-0.5 part, sulfurous gas 0.05-0.2 part.
2. the anti-infective aqueous adhesive of Interventional according to claim 1, it is characterized in that: each component by weight, 100 parts of a-alpha-cyanoacrylate n-octyls, 13.5 parts of polymethacrylate, 10 parts in tsiklomitsin, 5 parts of Saikexiaozuos, 0.2 part of Resorcinol, 0.05 part of sulfurous gas.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2012104124216A CN102925064A (en) | 2012-10-25 | 2012-10-25 | Interventional anti-infective water-based adhesive |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2012104124216A CN102925064A (en) | 2012-10-25 | 2012-10-25 | Interventional anti-infective water-based adhesive |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN102925064A true CN102925064A (en) | 2013-02-13 |
Family
ID=47639999
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2012104124216A Pending CN102925064A (en) | 2012-10-25 | 2012-10-25 | Interventional anti-infective water-based adhesive |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN102925064A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103272263A (en) * | 2013-05-22 | 2013-09-04 | 无锡市华明化工有限公司 | Medical adhesive |
| CN103432623A (en) * | 2013-08-22 | 2013-12-11 | 华南理工大学 | Medical adhesive and preparation method thereof |
| CN108939139A (en) * | 2018-08-04 | 2018-12-07 | 浙江派菲特新材料科技有限公司 | A kind of preparation method with efficient anti-inflammatory hemostatic function medical adhesive |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5807563A (en) * | 1997-01-10 | 1998-09-15 | Medlogic Global Corporation | Methods for draping surgical incision sites |
| CN1448187A (en) * | 2002-04-02 | 2003-10-15 | 成都航利生物材料研究所 | Medical surgical adhesive |
| WO2005000985A2 (en) * | 2003-06-03 | 2005-01-06 | Medlogic Global Limited | Antimicrobial phenol containing cyanoacrylate adhesive compositions |
| CN1850289A (en) * | 2006-05-08 | 2006-10-25 | 广州中医药大学 | Antibactrial wound suturing-free tissue adhesive |
-
2012
- 2012-10-25 CN CN2012104124216A patent/CN102925064A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5807563A (en) * | 1997-01-10 | 1998-09-15 | Medlogic Global Corporation | Methods for draping surgical incision sites |
| CN1448187A (en) * | 2002-04-02 | 2003-10-15 | 成都航利生物材料研究所 | Medical surgical adhesive |
| WO2005000985A2 (en) * | 2003-06-03 | 2005-01-06 | Medlogic Global Limited | Antimicrobial phenol containing cyanoacrylate adhesive compositions |
| CN1850289A (en) * | 2006-05-08 | 2006-10-25 | 广州中医药大学 | Antibactrial wound suturing-free tissue adhesive |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103272263A (en) * | 2013-05-22 | 2013-09-04 | 无锡市华明化工有限公司 | Medical adhesive |
| CN103272263B (en) * | 2013-05-22 | 2014-10-22 | 江苏高博智融科技有限公司 | Medical adhesive |
| CN103432623A (en) * | 2013-08-22 | 2013-12-11 | 华南理工大学 | Medical adhesive and preparation method thereof |
| CN103432623B (en) * | 2013-08-22 | 2015-04-22 | 华南理工大学 | Medical adhesive and preparation method thereof |
| CN108939139A (en) * | 2018-08-04 | 2018-12-07 | 浙江派菲特新材料科技有限公司 | A kind of preparation method with efficient anti-inflammatory hemostatic function medical adhesive |
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|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C12 | Rejection of a patent application after its publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20130213 |