CN102920885B - Medicine for treating bacterial vaginosis in gestation period - Google Patents
Medicine for treating bacterial vaginosis in gestation period Download PDFInfo
- Publication number
- CN102920885B CN102920885B CN201210471638.4A CN201210471638A CN102920885B CN 102920885 B CN102920885 B CN 102920885B CN 201210471638 A CN201210471638 A CN 201210471638A CN 102920885 B CN102920885 B CN 102920885B
- Authority
- CN
- China
- Prior art keywords
- parts
- medicine
- bacterial vaginosis
- fici pumilae
- gestation period
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Landscapes
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a medicine for treating bacterial vaginosis in a gestation period, and solves the treatment problem of bacterial vaginosis in the gestation period. The medicine is characterized in that the medicine is processed by various traditional Chinese medicines in part by weight as follows: 6-10 parts of holy basil, 8-15 parts of lindera erythrocarpa makinl, 8-15 parts of divaricate saposhnikovia root, 6-10 parts of common bombax flower, 6-10 parts of viola arcuata, 8-15 parts of Ipomoea pes-caprae, 6-10 parts of Chinese yam, 8-15 parts of white hyacinth bean and 3-6 parts of ficus pumila. Clinical experiments show that the medicine for treating bacterial vaginosis in gestation period has the characteristics of good curative effect and higher safety, and the medicine is worth applying clinically and popularizing.
Description
Technical field
The present invention relates to obstetrics' medical field, be specifically related to treat the medicine of bacterial vaginosis in pregnant women.
Background technology
Bacterial vaginosis (bacterial vaginosis, BV) is called nonspecific vaginitis in the past.First nineteen fifty-five Gardner and Dukes isolate Hemophilus vaginalis(Hemophilus vaginalis) from nonspecific vaginitis patient, thereby claim that this disease is vaginitis hemoptulus vaginalis.It is found that to the eighties this bacterium is different with other haemophilus, name as vagina Gartner bacterium, renaming as this sick is Gardnerella Vaginalis Vaginitis.Nineteen eighty-three has been selected the simplest and the clearest title---bacterial vaginosis in the international conference of Stockholm, and reason is that its pathogen is not only vagina Gartner bacterium, and also has other anaerobe; This sick inflammation is not obvious in addition, and leukocyte rareness in vaginal secretions, is called vaginosis more more appropriate than vaginitis.
Primary disease is women of child-bearing age's common disease, a certain domestic Epidemiological study demonstration, and its prevalence is 18.92% in adult healthy women, pregnant female bacterial vaginosis sickness rate 27.32%.Although bacterial vaginosis is usually considered to an inessential infection, and quite different for trimester of pregnancy anemia of pregnant woman.Modern study shows, BV is relevant with perinatal stage various diseases to trimester of pregnancy, as Intraamniotic infections, premature rupture of fetal membrane, start childbirth, premature labor, puerperal or post abortum endometritis, infection of newborn, the low weight of neonate and infect the hyperbilirubinemia of newborn causing in early days.Its approach may with pathogenic bacterium can be synthetic plurality of enzymes relevant, these enzymes reduce the elastic strength of cervical epithelial cells and chorio-amnion, bacterial penetration cervical mucosa barrier, enter uterine cavity, cause intrauterine infection and fetal infection, and can promote fetal membrane and the arachidonic release of decidua, and promote the synthetic of prostaglandin, cause premature labor.Therefore gravid woman carried out to antenatal BV examination and the anemia of pregnant woman of gestation merging BV is treated and is very important, should cause clinician's enough attention.
The proposed standard therapeutic scheme of BV is metronidazole, but metronidazole to First Trimester have teratogenesis may, therefore when gestation forbidding.Trimester of pregnancy, current generally accepted therapeutic scheme was: clindamycin 300mg, every day 2 times, the course for the treatment of 7d, but curative effect is lower, well below metronidazole.And puerpera more payes attention to for prenatal and postnatal care now, therefore a lot of puerperas use antibiotic to have resentment at First Trimester.
Summary of the invention
Technical assignment of the present invention is for above the deficiencies in the prior art, provides a kind of curative effect certainly, and side effect little the medicine for the treatment of bacterial vaginosis in pregnant women.
The technical scheme that the present invention solves its technical problem is: a kind of medicine for the treatment of bacterial vaginosis in pregnant women, it is characterized in that being processed by plurality of Chinese, its composition of raw materials and weight proportion are: 6 ~ 10 parts of Herba Lysimachiae foenum-graeci, fragrant 8 ~ 15 parts of Zhan's sugar, 8 ~ 15 parts of Radix Saposhnikoviaes, 6 ~ 10 parts of Flos Bombacis Malabaricis, 6 ~ 10 parts of Viola arcuata, 8 ~ 15 parts of Herba Ipomoeae Pes-Capraes, 6 ~ 10 parts of Rhizoma Dioscoreaes, 8 ~ 15 parts of Semen Lablab Albums, 3 ~ 6 parts of Caulis fici pumilae (Fructus Fici Pumilae)s.
Its optimum weight proportioning is: 8 parts of Herba Lysimachiae foenum-graeci, fragrant 10 parts of Zhan's sugar, 10 parts of Radix Saposhnikoviaes, 8 parts of Flos Bombacis Malabaricis, 8 parts of Viola arcuata, 10 parts of Herba Ipomoeae Pes-Capraes, 8 parts of Rhizoma Dioscoreaes, 10 parts of Semen Lablab Albums, 5 parts of Caulis fici pumilae (Fructus Fici Pumilae)s.
Wherein said: Herba Lysimachiae foenum-graeci, for Primulaceae Lysimachia plant Herba Lysimachiae foenum-graeci Lysimachia foenum-graecum Hance is with ground all herbal medicine.Nature and flavor are sweet, light, flat.Merit can heat clearing away, circulation of qi promoting, and pain relieving, drives ascarid.
Zhan's sugar is fragrant, is bark or the leaf of canella Cortex Linderae Fragrantis.Nature and flavor are pungent; Tepor.Merit can expelling wind and removing dampness; Removing toxic substances parasite killing.
Radix Saposhnikoviae is the dry root of umbelliferae Saposhnikovia divaricata Saposhnikovia divaricata (Turcz.) Schischk..Nature and flavor acrid, sweet, warm.Return bladder, liver, spleen channel.Merit can inducing diaphoresis to dispel wind, and victory is wet, relieving convulsion.
Flos Bombacis Malabarici is the flower of Bombacaceae plant kapok.Sweet in the mouth; Light; Cool in nature.Return spleen; Liver; Large intestine channel.Merit can heat clearing away; Dampness removing; Removing toxic substances; Hemostasis.
Viola arcuata is the herb of Violaceae plant common violet.Cool in nature, mildly bitter flavor.Heat-clearing and toxic substances removing; Cough-relieving; Hemostasis.
Herba Ipomoeae Pes-Capraes is the herb of Convolvulaceae morning glory two leaf Radix Ipomoeae Ipomoea pescarpae (L.) Sweet.Pungent, the micro-hardship of nature and flavor, wet.Merit can expelling wind and removing dampness, the detumescence of drawing out pus by applying a plaster to the affected part.
Rhizoma Dioscoreae is the dry rhizome of Dioscoreaceae plant Rhizoma Dioscoreae Dioscorea opposita Thunb..Nature and flavor are sweet, flat.Return spleen, lung, kidney channel.Merit can spleen reinforcing nourishing the stomach, the lung benefiting that promotes the production of body fluid, the kidney invigorating arresting seminal emission.
Semen Lablab Album is the dry mature seed of pulse family Dolichos plant Seem Lablab Album Dolichos lablab L..Nature and flavor are sweet, tepor.Return spleen, stomach warp.Merit can invigorating the spleen for eliminating dampness, and in relieve summer heat.
Caulis fici pumilae (Fructus Fici Pumilae) is stem, the leaf of moraceae plants Caulis fici pumilae (Fructus Fici Pumilae) Ficus pumila L..Sour in the mouth, cool in nature.Merit can expelling wind and removing dampness; Promoting blood circulation to remove obstruction in the collateral; Removing toxic substances and promoting subsidence of swelling.
Composition principle: the research of modern medicine pathogen shows, Gartner bacterium in Patients with Bacterial Vaginosis vaginal secretions, anaerobe are increased as bacteroid, Peptostreptococcus, Mobiluncus bacterium and mycoplasma hominis etc., than 100～1000 times of normal increases.Due to the undue growth of anaerobe, suppress the lactobacillus of normal energy generation hydrogen peroxide, after the hydrogen peroxide of energy kill bacteria reduces, anaerobe more can increase, and has formed vicious cycle.Lactobacillus reduces, and its lactic acid producing also reduces, and affects the reduction of vaginal pH.Anaerobe can produce a large amount of amines and other salt, causes the change of vaginal secretion chemical constituent, because can there is the clinical manifestation of special odor and pH value rising.We select Herba Lysimachiae foenum-graeci heat clearing away circulation of qi promoting, the fragrant expelling wind and removing dampness of Zhan's sugar, Radix Saposhnikoviae expelling wind and dampness, the clearing moist heat part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels is smooth clearly, wind degass to go and only itches, and inventor's clinical observation is for many years summed up, Herba Lysimachiae foenum-graeci, Zhan's sugar perfume, this three tastes medicine partner treatment of Radix Saposhnikoviae BV have feature rapidly and efficiently, the Experimental agents of inventor using these three herbal medicine mixing water decocts as drug sensitive experiment, discovery mixing water decoct can effectively be killed the pathogen in the positive cultivation of cervical secretions ware of BV, and can secondary fungus Bacillus proteus or staphy lococcus infection.Flos Bombacis Malabarici clearing away heat-damp and promoting diuresis, Viola arcuata heat-clearing and toxic substances removing, this two damp-heat in lower-JIAO clearly, approach is not by diuresis clearing away damp-heat, even if First Trimester uses, is safe yet, its mechanism may be relevant with its characteristic of " holding back ".Herba Ipomoeae Pes-Capraes, Caulis fici pumilae (Fructus Fici Pumilae) can strengthen the antipruritic effect de-tasting, and are the medicine taking stopgap measures.Rhizoma Dioscoreae spleen reinforcing kidney, Semen Lablab Album invigorating the spleen for eliminating dampness, to change source on water.
The present invention compared with the prior art, has following characteristics:
1, prescription uniqueness: avoid using the conventional treatment BV medicines such as Radix Sophorae Flavescentis, the Fructus Kochiae, Cortex Dictamni, be impairment of the kidney through the anxiety of Yuanyang without bitter cold, be applicable to trimester of pregnancy anemia of pregnant woman and use, even First Trimester also can be used safely;
2, fragrant, this three tastes medicine of Radix Saposhnikoviae of Herba Lysimachiae foenum-graeci, Zhan sugar is used in conjunction with, and effectively kills these BV main force pathogenic bacterium of Gartner bacterium, and can secondary fungus Bacillus proteus or staphy lococcus infection;
3, Flos Bombacis Malabarici, the clear damp-heat in lower-JIAO of Viola arcuata, the side effect increasing without urine, its mechanism may be relevant with its characteristic of " holding back ", is applicable to pregnant each phase anemia of pregnant woman and uses;
4, treating both the principal and secondary aspects of a disease: Herba Ipomoeae Pes-Capraes, Caulis fici pumilae (Fructus Fici Pumilae) can strengthen the antipruritic effect de-tasting is the medicine taking stopgap measures; Rhizoma Dioscoreae spleen reinforcing kidney, Semen Lablab Album invigorating the spleen for eliminating dampness, to change source on water;
5, medicine material consumption of the present invention is groped in a large number to sum up through inventor and is drawn, each raw material consumption is for all to have good curative effect in following weight parts scope.
Detailed description of the invention
Below in conjunction with practical situation, the specific embodiment of the present invention is elaborated.
Embodiment 1, crude drug weight proportion: Herba Lysimachiae foenum-graeci 6g, the fragrant 8g of Zhan's sugar, Radix Saposhnikoviae 8g, Flos Bombacis Malabarici 6g, Viola arcuata 6g, Herba Ipomoeae Pes-Capraes 8g, Rhizoma Dioscoreae 6g, Semen Lablab Album 8g, Caulis fici pumilae (Fructus Fici Pumilae) 3g.
Embodiment 2, crude drug weight proportion: Herba Lysimachiae foenum-graeci 10g, the fragrant 15g of Zhan's sugar, Radix Saposhnikoviae 15g, Flos Bombacis Malabarici 10g, Viola arcuata 10g, Herba Ipomoeae Pes-Capraes 15g, Rhizoma Dioscoreae 10g, Semen Lablab Album 15g, Caulis fici pumilae (Fructus Fici Pumilae) 6g.
Embodiment 3, crude drug weight proportion: Herba Lysimachiae foenum-graeci 8g, the fragrant 10g of Zhan's sugar, Radix Saposhnikoviae 10g, Flos Bombacis Malabarici 8g, Viola arcuata 8g, Herba Ipomoeae Pes-Capraes 10g, Rhizoma Dioscoreae 8g, Semen Lablab Album 10g, Caulis fici pumilae (Fructus Fici Pumilae) 5g.
When use, Chinese medicine Herba Lysimachiae foenum-graeci of the present invention, Zhan's sugar perfume, Radix Saposhnikoviae, Flos Bombacis Malabarici, Viola arcuata, Herba Ipomoeae Pes-Capraes, Rhizoma Dioscoreae, Caulis fici pumilae (Fructus Fici Pumilae) and Semen Lablab Album are decocted with water to twice, merging filtrate, a point morning and evening takes.
Except oral, decoct of the present invention also can, for pudendum washout or vaginadouche, also can be made other dosage forms in conjunction with Modern Pharmaceutics, as suppository etc.
Effective combination of said medicine, coordinates mutually, can effectively reach the object for the treatment of bacterial vaginosis in pregnant women, and side effect is less.The above results is that clinical data fully proves, interrelated data is as follows, and wherein drugs use is the crude drug weight proportion in embodiment 3.
1 object and method.
1.1 object.
1.1.1 case is chosen: be in January, 2010 ~ 2012 year JIUYUE anemia of pregnant woman 160 examples, all meet bacterial vaginosis diagnostic criteria, nearly 2 weeks without sexual life, do not use antibiotic, do not do vaginadouche.The equal nutriture of each case is good, and blood glucose, blood fat and hepatic and renal function are all in normal range.
1.1.2 bacterial vaginosis diagnostic criteria: be diagnosed as BV to meet >=7 points of three clinical diagnosis indexs the scorings of vaginal smear Nugem Gram's staining antibacterial.Clinical diagnosis index comprises: 1. homogenizing, thin vaginal secretions; 2. vaginal secretions pH value >4.5,3. the amine test positive; 4. the clues cell positive, examines under a microscope the vaginal epithelial cell coming off and sticks a large amount of granular things, and edge fogs, and is clues cell.Clues cell appears as the positive in 10 low-power fields.Nugent Gram's staining antibacterial point system, be exactly in 1000 times of oily Microscopic observation ne ar and quantity, as occur lactobacillus reduce or lack as, and mixed during with a large amount of Grain-positives or Grain-negative dialister bacterium and (or) the variable bending arc bacillus of Gram's staining, >=7 points of its scorings.
1.2 method.
1.2.1 grouping: selected anemia of pregnant woman's 160 examples, are divided into 2 groups, test group 80 examples, matched group 80 examples at random.20～38 years old test group age, average 26.21 ± 4.13 years old; Gestation 5～32 weeks, average 21.55 ± 3.51 weeks.21～36 years old test group age, average 25.27 ± 5.66 years old; Gestation 5～31 weeks, average 20.63 ± 4.83 weeks.Two groups of comparisons, age, pregnant all number difference not statistically significants, P>0.05.
1.2.2 Therapeutic Method: the control group clindamycin suppository 300mg, every day 2 times, the course for the treatment of 7d; The Chinese medicine of gained in the test group application embodiment of the present invention 3, every day 2 times, the course for the treatment of 7d.Within 7 days, bride visits her parents with her husband for the first time after the wedding examines understanding change of illness state in medication.Continue medication to 10 day, drug withdrawal 3 Tian Lai institute check clinical symptoms and lab testings.
1.2.3 curative effect determinate standard: cure: symptom, sign disappear, clues cell (-), vagina pH < 4.5,10%KOH tests (-); Effective: symptom, sign disappear substantially, clues cell (-), vagina pH < 4.5,10%KOH tests (-); Effective: symptom, sign part disappear, clues cell < 20%, vagina pH > 4.5,10%KOH tests (-); Invalid: symptom, sign be without obvious change, clues cell (+), vagina pH > 4.5,10%KOH tests (+).
1.2.4 safety evaluatio: all carry out the monitorings such as blood, urine, stool routine, liver, renal function, electrocardiogram before and after medication.
1.2.5 statistical analysis: carry out statistical analysis with SPSS 13.0, P< 0.05 indicates significant.
2 results.
The curative effect comparison of 2.1 liang of group cases: see the following form, obvious effective rate and total effective rate treatment group are obviously better than matched group (P<0.05); Extremely obviously (P<0.01) of cure rate difference.
| Number of cases | Recovery from illness | Effective | Effectively | Invalid | Effectively total | |
| Treatment group | 80 | 56/70.00% | 13/16.25% | 7/8.75% | 4/5.00% | 76/95.00% |
| Matched group | 80 | 34/41.98% | 25/30.86% | 10/12.35% | 12/14.81% | 69/85.19% |
| χ 2 | ? | 12.823 | 4.767 | 0.551 | 4.332 | 4.332 |
| P value | ? | 0 | 0.029 | 0.458 | 0.037 | 0.037 |
2.2 untoward reaction: patient's vital sign (blood pressure, heart rate, body temperature, breathing), physical examination, blood biochemical analysis, electrocardiogram, routine urinalysis and pregnancy period, other checked Non Apparent Abnormality during treating.
3. conclusion.
The demonstration of this result of study, the present invention treats bacterial vaginosis in pregnant women and has good effect and the higher feature of safety, clinic application, popularization.
Claims (2)
1. treat the medicine of bacterial vaginosis in pregnant women for one kind, it is characterized in that, its composition of raw materials and weight proportion are: 6 ~ 10 parts of Herba Lysimachiae foenum-graeci, fragrant 8 ~ 15 parts of Zhan's sugar, 8 ~ 15 parts of Radix Saposhnikoviaes, 6 ~ 10 parts of Flos Bombacis Malabaricis, 6 ~ 10 parts of Viola arcuata, 8 ~ 15 parts of Herba Ipomoeae Pes-Capraes, 6 ~ 10 parts of Rhizoma Dioscoreaes, 8 ~ 15 parts of Semen Lablab Albums, 3 ~ 6 parts of Caulis fici pumilae (Fructus Fici Pumilae)s.
2. a kind of medicine for the treatment of bacterial vaginosis in pregnant women according to claim 1, is characterized in that its weight proportion is: 8 parts of Herba Lysimachiae foenum-graeci, fragrant 10 parts of Zhan's sugar, 10 parts of Radix Saposhnikoviaes, 8 parts of Flos Bombacis Malabaricis, 8 parts of Viola arcuata, 10 parts of Herba Ipomoeae Pes-Capraes, 8 parts of Rhizoma Dioscoreaes, 10 parts of Semen Lablab Albums, 5 parts of Caulis fici pumilae (Fructus Fici Pumilae)s.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210471638.4A CN102920885B (en) | 2012-11-20 | 2012-11-20 | Medicine for treating bacterial vaginosis in gestation period |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210471638.4A CN102920885B (en) | 2012-11-20 | 2012-11-20 | Medicine for treating bacterial vaginosis in gestation period |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN102920885A CN102920885A (en) | 2013-02-13 |
| CN102920885B true CN102920885B (en) | 2014-09-17 |
Family
ID=47635910
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201210471638.4A Expired - Fee Related CN102920885B (en) | 2012-11-20 | 2012-11-20 | Medicine for treating bacterial vaginosis in gestation period |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN102920885B (en) |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1067239C (en) * | 1995-04-08 | 2001-06-20 | 吴建国 | Multipurpose body-building bath preparation and its production method |
| CN102600048B (en) * | 2012-03-16 | 2013-04-10 | 张玲 | Preparation method of medical antibiosis washing-protection liquid |
-
2012
- 2012-11-20 CN CN201210471638.4A patent/CN102920885B/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CN102920885A (en) | 2013-02-13 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN103638511A (en) | Postpartum stasis removing particles | |
| CN103349766B (en) | Pharmaceutical composition for endless postpartum lochia | |
| CN103301353B (en) | Pharmaceutical composition for treating atrophic vaginitis | |
| CN104721489A (en) | Chinese patent medicine for treating Parkinson disease and preparation method thereof | |
| CN104225218A (en) | Traditional Chinese medicine preparation for chronic urinary infection treatment | |
| CN104706953A (en) | Traditional Chinese medicine preparation for treating chronic cervicitis | |
| CN102920885B (en) | Medicine for treating bacterial vaginosis in gestation period | |
| CN103341059A (en) | Chinese medicine composition for treating non-gonococcal urethritis | |
| CN103432270A (en) | Traditional Chinese medicine composition for treating chronic prostatitis | |
| CN103301373B (en) | Pharmaceutical composition for treating postpartum perineal mucosal lesions | |
| CN102743686B (en) | The scorching clearing capsule of a kind of basin | |
| CN101024054B (en) | Oral Chinese medicine composition for treating glandular cystitis | |
| CN105920488A (en) | Traditional Chinese medicine leading-in liquid for coordinating with acusector and treating overactive bladder | |
| CN104398667A (en) | Traditional Chinese medicinal preparation for treating leucopenia after radiotherapy | |
| CN104474308A (en) | Traditional Chinese medicine composition for treating acute cystitis | |
| CN103800561A (en) | Traditional Chinese medicine for treating renal hematuria | |
| CN103520638B (en) | A kind of Traditional Chinese medicine compound composition for the treatment of prostate hyperplasia and preparation method thereof and application thereof | |
| CN102274442B (en) | Deer bone wine for treating arthralgia syndrome and preparation method and application thereof | |
| CN108042744A (en) | A kind of Chinese medicine composition and preparation method for being used to treat prostatic disorders | |
| CN103316258B (en) | Medicine composition for treating infantile vaginitis | |
| CN105168746B (en) | A kind of nursing medicine for the treatment of infantile oxyuriasis and preparation method thereof | |
| CN106266970B (en) | A kind of Chinese medicine composition treated production and cause endometritis | |
| CN105381387B (en) | A kind of drug and preparation method thereof for treating cystitis | |
| CN103301354B (en) | Preparation method of powder for treating infantile vaginitis | |
| CN105641057A (en) | Medicine composition for treating primary glomerular hematuria caused by failure of spleen to control blood vessels |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20140917 Termination date: 20151120 |
|
| EXPY | Termination of patent right or utility model |