CN102919240A - Tridemorph-containing sterilizing composition - Google Patents
Tridemorph-containing sterilizing composition Download PDFInfo
- Publication number
- CN102919240A CN102919240A CN2012103940556A CN201210394055A CN102919240A CN 102919240 A CN102919240 A CN 102919240A CN 2012103940556 A CN2012103940556 A CN 2012103940556A CN 201210394055 A CN201210394055 A CN 201210394055A CN 102919240 A CN102919240 A CN 102919240A
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- Prior art keywords
- tridemorph
- bactericidal composition
- methyl
- composition
- commercial
- Prior art date
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Landscapes
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Abstract
The invention discloses a tridemorph-containing sterilizing composition with a synergistic effect. The tridemorph-containing sterilizing composition comprises the following active ingredients of tridemorph (A) and one of methoxyl acrylate-type bactericides (B), wherein the weight ratio of the active ingredient A to the active ingredient B is 32:1-1:32. Aids and an excipient are added into the active ingredients to prepare a suspoemulsion, a suspension agent and the like. The sterilizing composition can be used for preventing and controlling diseases caused by bacteria of ascomycetes, bssidiomycetes and deuteromycetes.
Description
The application is for dividing an application, and original application is the patent application " a kind of bactericidal composition that contains tridemorph " of Shaanxi agricultural chemicals Co., Ltd of U.S. nation, and the application number of original application is ︰ 201010579234.8, and original application day is 2010.12.8.
Technical field
The invention belongs to the disinfectant use in agriculture field, relate to a kind of preparation and application that contains the bactericidal composition of tridemorph.
Background technology
Sustainable development along with agricultural development; the mankind constantly strengthen environmental protection consciousness; the impact that agricultural chemicals cause environment extremely people is paid close attention to, because a large amount of chemical pesticides that use, and the pollution in various degree that all arrived of air, water source, soil and crops.Therefore, reduce the use of chemical pesticide, release that preventive effect is good, consumption is low, environmental protection, and the Pesticidal products that can delaying drug resistance produces speed become the trend of agricultural chemicals research and development.
Tridemorph (tridemorph) is the morpholine series bactericidal agent.Molecular formula is C
19H
39NO (approximately), chemical name: 2,6-dimethyl-4-tridecyl morpholine.
Tridemorph is a kind of broad spectrum activity systemic fungicide with protection and therapeutic action, can be absorbed by the root of plant, stem, leaf, and the plurality of plant diseases that basidiomycetes, sac fungi and imperfect fungus are caused is effective, mainly is the biosynthesis that suppresses the ergosterol of germ.
But the long-term tridemorph single dose of using separately easily makes disease produce resistance, causes the problems such as dosage increase, preventive effect reduction, lasting period shortening, is unfavorable for sustainable development.And that the active ingredient of the different mechanisms of action is carried out is composite, makes to delay the common method that disease develops immunity to drugs, and according to the effect in the production application, judge this composite be synergistic effect or antagonism.Complex role is significantly filled a prescription, and can obviously improve preventive effect, greatly reduces the dosage of agricultural chemicals, also can enlarge fungicidal spectrum, improves germicidal efficiency.
Summary of the invention
The objective of the invention is to propose a kind of generation of disease drug resistance or delaying drug resistance of preventing and produce speed, the bactericidal composition that contains tridemorph that use cost is low, preventive effect is good.
Degradation problem under the resistance generation that long-term use may bring for the tridemorph single dose, the drug effect.The inventor finds by a large amount of indoor biometricses and field control effectiveness test: tridemorph and methoxy acrylic bactericide have obvious synergistic effect with the certain proportion rear use that is mixed.
Described methoxy acrylic (strobilurins) bactericide is the new type bactericide that in these years occurs, and sterilization mechanism is unique, has and permeates in systemic action, low toxicity, efficient, broad spectrum activity.This series bactericidal agent all is the cell mitochondrial respiration inhibitor of pathogen, shifts to suppress mitochondrial respiratory by the electronics in the pathogen physiological activity, and the interference cell energy supply, makes the pathogen cell death.Sac fungi, pityrosporion ovale, oomycetes and Fungi Imperfecti there is good preventive effect.Good to white powder, anthracnose, scab, epidemic disease, downy mildew control efficiency.
The inventor is by further research discovery, and in the described methoxy acrylic bactericide there be comparatively preferred composition: Fluoxastrobin, kresoxim-methyl, pyraclostrobin, ZJ0712, oxime bacterium ester, Enestroburin, alkene oxime amine etc.
Fluoxastrobin (azoxystrobin) is the heterocyclic nitrogen-group fungicide of Britain ICI company exploitation.Molecular formula: C
24H
17N
3O
5, chemical name: (E)-2-{2-[6 (2-cyano-benzene oxygen) pyrimidine-4-yl oxygen] phenyl }-the 3-methoxy acrylate.Fluoxastrobin belongs to the mitochondrial respiratory inhibitor, namely passes through to shift to the electronics of cromoci at cytochrome B cl, thereby suppresses mitochondrial breathing.The bacterial strain that 14-demethylation enzyme inhibitor, benzamides, dicarboxylic dihydrazides amine and benzimidazole is produced resistance is effective.Have protection, root out, infiltration, systemic activity.Suppress spore germination and mycelial growth and produce spore always.
Kresoxim-methyl (kresoxim-methyl) is the methoxy acrylic new type bactericide of BASF Aktiengesellschaft.Molecular formula: C
18H
19NO
4, chemical name: methyl (E)-2-methoxyimino-2-[2-(0-toloxyl) phenyl] and acetate.Kresoxim-methyl belongs to the cell mitochondrial respiration inhibitor, shifts to suppress mitochondrial respiratory by electronics between cytochrome b and C1, and the interference cell energy supply makes the pathogen cell death.Tool is protected, treats, is rooted out, infiltration, systemic activity, and fungicidal spectrum is wide, and the plurality of plant diseases that sac fungi, flagellum mattress and imperfect fungus are caused has preferably control efficiency.
Pyraclostrobin (Pyraclostrobin) molecular formula: C
19H
18CIN
3O
4, chemical name: N-[2-[[1-(4-chlorphenyl) pyrazole-3-yl] and the oxygen methyl] phenyl]-N-methoxyl group methyl carbamate.Be the efficient mitochondrial respiratory inhibitor after improve on the kresoxim-methyl basis, have protection, treatment, blade infiltration conduction.
Alkene oxime amine was found by Shenyang Chemical Engineering Inst in 1999, molecular formula: C
21H
20CI
2N
3O
3, chemical name: (E, E, E)-N-methyl-2-[((((1-methyl-3-(2,, 6 ,-dichlorophenyl)-the 2-acrylic) imino group) the oxygen base) methyl) phenyl]-the 2-methoxyimino acetic amide.Alkene oxime amine acts on the mitochondrial respiratory of fungi, medicament by with the mitochondria electron transport chain in the combination of compound III (Cyt bc1 compound), to Cyt c, the ATP that destroys fungi is synthetic by Cyt bc1 complex logistics for the blocking-up electronics, thereby plays the effect of inhibition or kill fungi.
Oxime bacterium ester (Trifloxystrobin) molecular formula: C
20H
19F
3N
2O
4, chemical name: (2Z)-2-methoxyimino-2-[2-[[1-[3-(trifluoromethyl) phenyl] ethyleneimino] the oxygen methyl] phenyl] methyl acetate.It is capable of being fast degraded in the water at soil, therefore environmentally safe.
Enestroburin (Enestroburin), molecular formula: C
22H
27ClNO
4, chemical name: 3-methoxyl group-2-[2-((((1-methyl-3-(4-chlorphenyl)-2-acrylic fork) amino) oxygen)-methyl) phenyl] methyl acrylate
ZJ0712 (kresoxim-methyl) is the novel methoxy acrylic new type bactericide by the exploitation of Zhejiang chemical research institute.Molecular formula: C
20H
22O
4, chemical name: (E) 2-[2-(2,5-dimethyl phenoxy toluene)-phenyl]-the 3-methoxy-methyl acrylate.The protection of ZJ0712 tool and therapeutic action, toxicity is low, and active high, fungicidal spectrum is wide, and the plurality of plant diseases that sac fungi, flagellum mattress and imperfect fungus are caused has preferably control efficiency, particularly powdery mildew of cucumber and downy mildew of garpe is had very excellent preventive effect.
The bactericidal composition that the present invention proposes contains A, two kinds of active components of B, and an amount of surfactant adjuvant and carrier.
Active component A is selected from tridemorph.
Active component B is selected from a kind of in the above-mentioned methoxy acrylic bactericide:
Comparatively preferred active component is a kind of in Fluoxastrobin, kresoxim-methyl, pyraclostrobin, oxime bacterium ester, Enestroburin, alkene oxime amine, the ZJ0712.
The ratio of weight and number of A, two kinds of active components of B is 32 ︰, 1～1 ︰ 32, is preferably 16 ︰, 1～1 ︰ 16.
Described bactericidal composition is characterized in that: the ratio of weight and number of tridemorph and Fluoxastrobin is 16 ︰, 1～1 ︰ 8 in the bactericidal composition, is preferably 8 ︰, 1～1 ︰ 8.
Described bactericidal composition is characterized in that: the ratio of weight and number of tridemorph and kresoxim-methyl is 16 ︰, 1～1 ︰ 8 in the bactericidal composition, is preferably 8 ︰, 1～1 ︰ 8.
Described bactericidal composition is characterized in that: the ratio of weight and number of tridemorph and pyraclostrobin is 16 ︰, 1～1 ︰ 8 in the bactericidal composition, is preferably 8 ︰, 1～1 ︰ 8.
Described bactericidal composition is characterized in that: the ratio of weight and number of tridemorph and oxime bacterium ester is 16 ︰, 1～1 ︰ 8 in the bactericidal composition, is preferably 8 ︰, 1～1 ︰ 8.
Described bactericidal composition is characterized in that: the ratio of weight and number of tridemorph and Enestroburin is 16 ︰, 1～1 ︰ 8 in the bactericidal composition, is preferably 8 ︰, 1～1 ︰ 8.
Described bactericidal composition is characterized in that: the ratio of weight and number of tridemorph and alkene oxime amine is 16 ︰, 1～1 ︰ 8 in the bactericidal composition, is preferably 16 ︰, 1～1 ︰ 4.
Described bactericidal composition is characterized in that: the ratio of weight and number of tridemorph and ZJ0712 is .16 ︰ 1～1 ︰ 8 in the bactericidal composition, is preferably 16 ︰, 1～1 ︰ 1.
Amount of application when the content of active component depends on independent use in the present composition also depends on mixed ratio and the synergistic effect degree of a kind of compound and another kind of compound, and the while is also relevant with the target fungi.Usually active weight percentage is 1～80% of gross weight in the composition, and better is 10%～50%.
At least contain a kind of surfactant in the bactericidal composition of the present invention, the dispersion of active component in water when being beneficial to use.Surface-active contents is 5～40% of total formulation weight amount, and surplus is solid or liquid diluent.
The selected surfactant of bactericidal composition of the present invention is known in those skilled in the art: can be selected from one or more in dispersant, wetting agent, emulsifier, binding agent or the defoamer.According to different dosage form, can also contain disintegrant known in those skilled in the art, antifreeze etc. in the preparation.
Composition of the present invention can be by the user before use through dilution or directly use.Its preparation can by common processing method preparation, after being about to active substance and liquid flux or solid carrier mixing, add one or more in surfactant such as dispersant, stabilizing agent, wetting agent, adhesive, the defoamer etc. again.
Bactericidal composition of the present invention can be processed into acceptable formulation on any agricultural chemicals on demand.Wherein more preferably formulation such as water dispersible granules, suspension emulsion, suspending agent, aqueous emulsion or microemulsion.
Microbicide compositions of the present invention has protection concurrently, treats and roots out activity; available and various crop be such as fruit tree, wheat, paddy rice, tomato, grape, cucumber, capsicum, pimento, eggplant, strawberry, vegetables and some flower plants, prevent and treat young Oomycete, Phycomycetes, Ascomycetes and the microbial plant disease of deuteromycetes pathogeny as: powdery mildew, gray mold, rot, leaf mold, anthracnose, rust, fusarium wilt, epidemic disease etc. have preferably preventive effect.
Composition of the present invention has following advantage: the mechanism of action of two kinds of active ingredients is different in (one) present composition, and mutually being mixed can not produce conflict; (2) present composition shows significant synergistic effect in certain ratio range, has both improved protection effect, has reduced mu dosage and cost, has enlarged again fungicidal spectrum; (3) present composition helps avoid the drug-fast generation of germ and slows down drug-fast generation speed, thereby has solved resistance and Cost Problems in the present agricultural chemicals single dose application process; (4) present composition is difficult for producing poisoning, is convenient to transportation and storage, and being mixed will be lower on the impact of environment, safer.
Embodiment
After different active ingredients are mixed, usually show three kinds of type of action, summation action, synergistic effect and antagonism.But be specially which kind of effect, unpredictable, only have by great many of experiments and just can know.The prescription that compound synergic is good owing to obviously having improved actual preventive effect, has reduced the agricultural chemicals usage amount, thereby has greatly delayed the drug-fast generation speed of germ, is the important means of scientific prevention and cure disease.
To further instruction of the present invention, the percentage among the embodiment all is weight percentage below in conjunction with embodiment, but the present invention is not limited thereto.
The embodiment of the invention is the method that adopts Toxicity Determination and field trial to combine.First by Toxicity Determination, the synergy ratio (SR) after clear and definite two kinds of medicaments are composite by a certain percentage, SR＜0.5 is antagonism, and 0.5≤SR≤1.5 are summation action, and SR＞1.5 are synergistic effect, on this basis, carry out field trial again.
Implementation of an application example one: active component (A) tridemorph is with (B) methoxy acrylic bactericide is composite to the powdery mildew of cucumber Toxicity Determination
Test medicine provides by Shaanxi agricultural chemicals Co., Ltd of U.S. nation.
After each medicament establishment concentration range was determined in prerun, each medicament was established respectively 5 dosage by active constituent content and is processed, and established the clear water contrast.Carry out with reference to " farm-chemical indoor determination test rule bactericide ", adopt the mycelial growth rate method to measure medicament to the virulence of powdery mildew of cucumber.Measure colony diameter with the right-angled intersection method behind the 72h, calculate and respectively process net growth, mycelial growth inhibition rate.
Mycelial growth inhibition rate is converted into probit value (y), and liquor strength (μ g/mL) converts logarithm value (x) to, tries to achieve virulence regression equation (y=a+bx) with method of least squares, and calculates thus the EC of every kind of medicament
50Value.Calculate the different proportioning synergy ratios (SR) of two medicaments according to the Wadley method simultaneously, SR＜0.5 is antagonism, and 0.5≤SR≤1.5 are summation action, and SR＞1.5 are synergistic effect.Computing formula is as follows:
Wherein: a, b are respectively active component (A) tridemorph and (B) methoxy acrylic bactericide shared ratio in combination;
A is selected from tridemorph;
B is methoxy acrylic bactericide: a kind of in Fluoxastrobin, kresoxim-methyl, pyraclostrobin, oxime bacterium ester, Enestroburin, alkene oxime amine, the ZJ0712.
It is as shown in the table for result of the test:
Toxicity test result one
Table 1 Fluoxastrobin, tridemorph and composite toxicity test analysis of results table to powdery mildew of cucumber thereof
As shown in Table 1, tridemorph, Fluoxastrobin are to the EC of powdery mildew of cucumber
50Be respectively 12.34mg/L and 6.02mg/L.The virulence of Fluoxastrobin is higher than the virulence of tridemorph.Tridemorph and Fluoxastrobin proportioning are mixed in 32 ︰, 1 to 1 ︰, 32 scopes and all show synergistic effect, and wherein, both mixed synergies in 16 ︰, 1 to 1 ︰, 16 scopes are comparatively desirable, and mixed synergies is particularly outstanding in 8 ︰, 1 to 1 ︰, 8 scopes.
Toxicity test result two
Table 2 kresoxim-methyl, tridemorph and composite toxicity test analysis of results table to powdery mildew of cucumber thereof
As shown in Table 2, tridemorph, kresoxim-methyl are to the EC of powdery mildew of cucumber
50Be respectively 12.34mg/L and 1.35mg/L.The virulence of kresoxim-methyl is higher than the virulence of tridemorph.Tridemorph and kresoxim-methyl proportioning are mixed in 32 ︰, 1 to 1 ︰, 32 scopes and all show synergistic effect, and wherein, both mixed synergies in 16 ︰, 1 to 1 ︰, 16 scopes are comparatively desirable, and mixed synergies is particularly outstanding in 16 ︰, 1 to 1 ︰, 8 scopes.
Toxicity test result three
Table 3 pyraclostrobin, tridemorph and composite toxicity test analysis of results table to powdery mildew of cucumber thereof
As shown in Table 3, tridemorph, kresoxim-methyl are to the EC of powdery mildew of cucumber
50Be respectively 12.34mg/L and 1.32mg/L.The virulence of kresoxim-methyl is higher than the virulence of tridemorph.Tridemorph and kresoxim-methyl proportioning are mixed in 32 ︰, 1 to 1 ︰, 32 scopes and all show synergistic effect, and wherein, both mixed synergies in 16 ︰, 1 to 1 ︰, 16 scopes are comparatively desirable, and mixed synergies is particularly outstanding in 16 ︰, 1 to 1 ︰, 8 scopes.
Toxicity test result four
Table 4 oxime bacterium ester, tridemorph and composite toxicity test analysis of results table to powdery mildew of cucumber thereof
As shown in Table 4, tridemorph, oxime bacterium ester are to the EC of powdery mildew of cucumber
50Be respectively 12.34mg/L and 1.51mg/L.The virulence of oxime bacterium ester is higher than the virulence of tridemorph.Tridemorph and oxime bacterium ester proportioning are mixed in 32 ︰, 1 to 1 ︰, 32 scopes and all show synergistic effect, and wherein, both mixed synergies in 16 ︰, 1 to 1 ︰, 16 scopes are comparatively desirable, and mixed synergies is particularly outstanding in 16 ︰, 1 to 1 ︰, 8 scopes.
Toxicity test result five
Table 5 Enestroburin, tridemorph and composite toxicity test analysis of results table to powdery mildew of cucumber thereof
As shown in Table 5, tridemorph, Enestroburin are to the EC of powdery mildew of cucumber
50Be respectively 12.34mg/L and 1.54mg/L.The virulence of Enestroburin is higher than the virulence of tridemorph.Tridemorph and Enestroburin proportioning are mixed in 32 ︰, 1 to 1 ︰, 32 scopes and all show synergistic effect, and wherein, both mixed synergies in 16 ︰, 1 to 1 ︰, 16 scopes are comparatively desirable, and mixed synergies is particularly outstanding in 16 ︰, 1 to 1 ︰, 8 scopes.
Toxicity test result six
Table 6 alkene oxime amine, tridemorph and composite toxicity test analysis of results table to powdery mildew of cucumber thereof
As shown in Table 6, tridemorph, Enestroburin are to the EC of powdery mildew of cucumber
50Be respectively 12.34mg/L and 0.83mg/L.The virulence of Enestroburin is higher than the virulence of tridemorph.Tridemorph and Enestroburin proportioning are mixed in 32 ︰, 1 to 1 ︰, 32 scopes and all show synergistic effect, and wherein, both mixed synergies in 16 ︰, 1 to 1 ︰, 8 scopes are comparatively desirable, and mixed synergies is particularly outstanding in 16 ︰, 1 to 1 ︰, 4 scopes.
Toxicity test result seven
Table 7 ZJ0712, tridemorph and composite toxicity test analysis of results table to powdery mildew of cucumber thereof
As shown in Table 7, tridemorph, ZJ0712 are to the EC of powdery mildew of cucumber
50Be respectively 12.34mg/L and 0.16mg/L.The virulence of ZJ0712 is higher than the virulence of tridemorph.Tridemorph and ZJ0712 proportioning are mixed in 64 ︰, 1 to 1 ︰, 16 scopes and all show synergistic effect, and wherein, both mixed synergies in 32 ︰, 1 to 1 ︰, 8 scopes are comparatively desirable, and mixed synergies is particularly outstanding in 16 ︰, 1 to 1 ︰, 1 scope.
Exemplary application example two:
1, the preparation of suspension emulsion
When making suspension emulsion, composition comprises following constituent content: active components A 1 ~ 40%, active component B 1 ~ 40%, emulsifier 2 ~ 12%, disperse wetting agent 2 ~ 10%, defoamer 0.1 ~ 2%, thickener 0.1 ~ 2%, antifreeze 0.1 ~ 8%, stabilizing agent 0.05 ~ 3%, water to add to 100%.
Dispersant, defoamer, thickener, antifreeze, stabilizing agent in the above-mentioned formulation material are mixed through high speed shear, add the former medicine of active components A, ball milling is 2 ~ 3 hours in ball mill, make diameter of particle all below 5 μ m, make suspension, then with the former medicine of active component B, emulsifier and various auxiliary agent with the direct emulsification of high speed agitator in suspending agent, make suspension emulsion product of the present invention.
Embodiment 1 Fluoxastrobin 20%, tridemorph 30%, OP-10 phosphate 8%, polyoxyethylene carboxylate 4%, soapberry powder 5%, silicone compound 0.1%, hydroxyethylcellulose 0.1%, ethylene glycol 2%, deionized water add to 100%, mix to make 50% Fluoxastrobin tridemorph suspension emulsion.
Embodiment 2 kresoxim-methyls 20%, tridemorph 25%, polycarboxylate 2%, alkyl benzene sulfonate calcium salt 5%, lauryl sodium sulfate 2%, silicone compound 0.1%, polyethylene glycol 0.5%, glycerine 4%, deionized water add to 100%, mix to make 45% kresoxim-methyl tridemorph suspension emulsion.
Embodiment 3 pyraclostrobins 10%, tridemorph 30%, alkylphenol-formaldehyde resin polyoxy ethyl ether 4%, naphthalene sulfonic acid-formaldehyde condensation product 2%, pull open powder 2%, silicone compound 0.1%, polyethylene glycol 0.5%, glycerine 4%, deionized water and add to 100%, mix making 40% pyraclostrobin tridemorph suspension emulsion.
Embodiment 4 alkene oxime amines 10%, tridemorph 25%, castor oil polyoxyethylene ether 5%, methyl naphthalene sulfonate formaldehyde condensate 10%, xanthans 2%, agricultural newborn 600# phosphate 3%, glycerine 4%, deionized water add to 100%, mix to make 35% alkene oxime amine tridemorph suspension emulsion.
Embodiment 5 oxime bacterium esters 5%, tridemorph 25%, triethanolamine salt 5%, sodium lignin sulfonate 4%, silkworm excrement 2%, silicone compound 0.1%, hydroxyethylcellulose 0.1%, ethylene glycol 2%, deionized water add to 100%, mix to make 30% oxime bacterium ester tridemorph suspension emulsion.
Embodiment 6 Enestroburins 15%, tridemorph 10%, Tween 80 5%, methyl naphthalene sulfonate formaldehyde condensate 10%, gelatin 2%, polyethylene glycol 2%, silicone oil 0.2%, deionized water add to 100%, mix to make 25 Enestroburin tridemorph suspension emulsions.
Embodiment 7 ZJ0712 10%, tridemorph 10%, alkyl biphenyl ether disulfonic acid magnesium salts 4%, polyoxyethylene nonylphenol ether phosphate 5%, aluminium-magnesium silicate 1%, ethylene glycol 4%, white carbon 3%, organosilicon 0.2%, deionized water adds to 100%, mixes to make 20% ZJ0712 tridemorph suspension emulsion.
2, the preparation of suspending agent
Comprise following constituent content when composition is made suspending agent: active components A 1 ~ 40%, active component B 1 ~ 40%, dispersant 2 ~ 10%, wetting agent 2 ~ 10%, defoamer 0.1 ~ 1%, thickener 0.1 ~ 2%, antifreeze 0.1 ~ 8%, deionized water add to 100%.
Dispersant, wetting agent, defoamer, thickener, antifreeze in the above-mentioned formulation material are mixed through high speed shear, add the former medicine of active components A, the former medicine of active component B, ball milling is 2 ~ 3 hours in ball mill, make diameter of particle all below 5 μ m, make suspending agent product of the present invention.
Embodiment 8 Fluoxastrobins 10%, tridemorph 40%, polyoxyethylene carboxylate 4%, soapberry powder 5%, silicone compound 0.1%, hydroxyethylcellulose 0.1%, ethylene glycol 2%, deionized water add to 100%, mix to make 50% Fluoxastrobin tridemorph suspending agent.
Embodiment 9 kresoxim-methyls 10%, tridemorph 35%, polycarboxylate 2%, lauryl sodium sulfate 2%, silicone compound 0.1%, polyethylene glycol 0.5%, glycerine 4%, deionized water add to 100%, mix to make 45% kresoxim-methyl tridemorph suspending agent.
Embodiment 10 pyraclostrobins 30%, tridemorph 10%, naphthalene sulfonic acid-formaldehyde condensation product 2%, pull open powder 2%, silicone compound 0.1%, polyethylene glycol 0.5%, glycerine 4%, deionized water and add to 100%, mix making 40% pyraclostrobin tridemorph suspending agent.
Embodiment 11 alkene oxime amines 15%, tridemorph 20%, methyl naphthalene sulfonate formaldehyde condensate 10%, xanthans 2%, agricultural newborn 600# phosphate 3%, glycerine 4%, deionized water add to 100%, mix to make 35% alkene oxime amine tridemorph suspending agent.
Embodiment 12 oxime bacterium esters 25%, tridemorph 5%, sodium lignin sulfonate 4%, silkworm excrement 2%, silicone compound 0.1%, hydroxyethylcellulose 0.1%, ethylene glycol 2%, deionized water add to 100%, mix to make 30% oxime bacterium ester tridemorph suspending agent.
Embodiment 13 Enestroburins 20%, tridemorph 5%, methyl naphthalene sulfonate formaldehyde condensate 10%, gelatin 2%, polyethylene glycol 2%, silicone oil 0.2%, deionized water add to 100%, mix to make 25 Enestroburin tridemorph suspending agents.
Embodiment 14 ZJ0712 5%, tridemorph 15%, polyoxyethylene nonylphenol ether phosphate 5%, aluminium-magnesium silicate 1%, ethylene glycol 4%, white carbon 3%, organosilicon 0.2%, deionized water adds to 100%, mixes to make 20% ZJ0712 tridemorph suspending agent.
3, the preparation of aqueous emulsion
Comprise following constituent content when composition is made aqueous emulsion: active components A 1 ~ 40%, active component B 1 ~ 40%, solvent 1 ~ 30%, emulsifier 1 ~ 15%, co-emulsifier 0 ~ 8%, antifreeze 0 ~ 10%, thickener 0.1 ~ 2%, defoamer 0.01 ~ 2%, deionized water are supplied surplus.
Above-mentioned formulation material is mixed, effective active composition, solvent, emulsifier, co-emulsifier are added together, make to be dissolved into even oil phase; Water, antifreeze, thickener, defoamer are mixed, become the homogeneous water.Under high-speed stirred, water is added oil phase, make aqueous emulsion product of the present invention.
Embodiment 15 tridemorphs 5%, kresoxim-methyl 40%, ethyl acetate 20%, acetonitrile 5%, castor oil polyoxyethylene ether 5%, polyvinyl alcohol 1%, propane diols 5%, lauric acid 0.5%, deionized water adds to 100%, mixes to make 45% tridemorph kresoxim-methyl aqueous emulsion.
Embodiment 16 tridemorphs 30%, Fluoxastrobin 8%, methyl alcohol 18%, acetone 8%, alkylphenol polyoxyethylene 5%, polyvinyl alcohol 1%, glycerine 5%, silicone oil 0.5%, deionized water adds to 100%, mixes to make 38% tridemorph azoxystrobin water emulsion.
Embodiment 17 tridemorphs 30%, pyraclostrobin 5%, methyl alcohol 15%, dimethyl sulfoxide (DMSO) 8%, fatty alcohol-polyoxyethylene ether 5%, xanthans 1%, glycerine 5%, aluminium-magnesium silicate 0.3%, deionized water adds to 100%, mixes to make 35% tridemorph pyraclostrobin aqueous emulsion.
Embodiment 18 tridemorphs 20%, ZJ0712 10%, ethanol 15%, ether 8%, sapn 5%, xanthans 1%, glycerine 5%, aluminium-magnesium silicate 0.3%, deionized water adds to 100%, mixes to make 30% tridemorph ZJ0712 aqueous emulsion.
Embodiment 19 tridemorphs 8%, alkene oxime amine 20%, cyclohexane 12%, dimethyl sulfoxide (DMSO) 8%, tween 5%, gelatin 1%, olive oil 5%, polyethylene glycol 0.5%, deionized water adds to 100%, mixes to make 28% tridemorph alkene oxime amine aqueous emulsion.
Embodiment 20 tridemorphs 15%, Enestroburin 10%, methyl alcohol 15%, ether 8%, fatty alcohol-polyoxyethylene ether 5%, xanthans 1%, glycerine 5%, aluminium-magnesium silicate 0.3%, deionized water adds to 100%, mixes to make 25% tridemorph Enestroburin aqueous emulsion.
Embodiment 21 tridemorphs 10%, oxime bacterium ester 5%, methyl alcohol 15%, dimethyl sulfoxide (DMSO) 8%, fatty alcohol-polyoxyethylene ether 5%, polyvinyl alcohol 2%, glycerine 1%, laruyl alcohol 0.3%, deionized water adds to 100%, mixes to make 15% tridemorph trifloxystrobin water emulsion.
4, the preparation of microemulsion
Comprise following constituent content when composition is made microemulsion: active components A 1 ~ 40%, active component B1 ~ 40%, solvent 1 ~ 30%, emulsifier 3 ~ 20%, co-emulsifier 0 ~ 12%, antifreeze 0 ~ 10%, thickener 0.1 ~ 2%, defoamer 0.01 ~ 2%, stabilizing agent 0 ~ 4%, deionized water is supplied surplus.
The former medicine of active components A and the former medicine of active component B are dissolved in the homogenizer that solvent and cosolvent are housed; Strongly mix after joining emulsifier, stabilizing agent and antifreeze, water in the homogenizer that mentioned solution is housed and homogenize, obtain at last the as clear as crystal microemulsion product of the present invention of outward appearance.
Embodiment 22 tridemorphs 5%, kresoxim-methyl 50%, ether 18%, alkylphenol-formaldehyde resin polyoxy ethyl ether 8%, butanols 5%, hydroxyethylcellulose 3%, sodium salicylate 2%, organosilicon 0.5%, deionized water adds to 100%, mixes to make 55% tridemorph kresoxim-methyl microemulsion.
Embodiment 23 tridemorphs 10%, Fluoxastrobin 40%, olive oil 12%, phenethyl phenol polyethenoxy ether 8%, tetradecanol-15%, polyvinyl alcohol 2%, sodium sorbate 2%, silicone defoaming agent 0.5%, deionized water adds to 100%, mixes to make 50% tridemorph Fluoxastrobin microemulsion.
Embodiment 24 tridemorphs 32%, pyraclostrobin 2%, cyclohexane 12%, castor oil polyoxyethylene ether 8%, isobutanol 5%, hydroxyethylcellulose 2%, salicylic acid 2%, silicone defoaming agent 0.5%, deionized water adds to 100%, mixes to make 34% tridemorph pyraclostrobin microemulsion.
Embodiment 25 tridemorphs 40%, oxime bacterium ester 8%, acetonitrile 20%, alkylphenol-formaldehyde resin polyoxy ethyl ether 8%, butanols 5%, hydroxyethylcellulose 2%, sodium sorbate 2%, silicone defoaming agent 0.5%, deionized water adds to 100%, mixes to make 48% tridemorph oxime bacterium ester microemulsion.
Embodiment 26 tridemorphs 40%, Enestroburin 5%, methyl alcohol 15%, phenethyl phenol polyethenoxy ether 8%, tetradecanol-15%, polyvinyl alcohol 2%, sodium salicylate 2%, silicone defoaming agent 0.5%, deionized water adds to 100%, mixes to make 45% tridemorph Enestroburin microemulsion.
Embodiment 27 tridemorphs 25%, alkene oxime amine 5%, ethyl acetate 12%, castor oil polyoxyethylene ether 8%, isobutanol 5%, hydroxyethylcellulose 2%, sodium sorbate 2%, silicone oil 0.3%, deionized water adds to 100%, mixes to make 30% tridemorph alkene oxime amine microemulsion.
Embodiment 28 tridemorphs 16%, ZJ0712 2%, ethanol 12%, castor oil polyoxyethylene ether 8%, isobutanol 5%, hydroxyethylcellulose 2%, salicylate hydrochlorate 2%, organosilicon 0.5%, deionized water adds to 100%, mixes to make 18% tridemorph ZJ0712 microemulsion.
A kind of in active components A in the above-mentioned the implementation of Formulation Example (tridemorph) and B(Fluoxastrobin, kresoxim-methyl, pyraclostrobin, ZJ0712, oxime bacterium ester, Enestroburin, the alkene oxime amine) ratio can be adjusted in the synergy scope of 32 ︰, 1 ~ 1 ︰ 32, thereby forms new the implementation of Formulation Example.
Embodiment uses three: the bactericidal composition that contains tridemorph is prevented and treated the powdery mildew of cucumber test of pesticide effectiveness
This experimental establishment is in suburb, county, Tai'an, Gansu Province, and test medicine is researched and developed, provided by Shaanxi agricultural chemicals Co., Ltd of U.S. nation; Contrast medicament: 250g/L Fluoxastrobin suspending agent (commercial), 50% water dispersion granules agent of Kresoxim (commercial), 25% pyraclostrobin missible oil (commercial), 5% alkene oxime amine missible oil (commercial), 25% oxime bacterium emulsifiable concentrate (commercial), 25% Enestroburin missible oil (commercial), 10% ZJ0712 suspending agent (commercial), 750g/L tridemorph missible oil (commercial).
The investigation powdery mildew of cucumber state of an illness before the medicine, in for the first time dispenser of state of an illness initial stage, dispenser in per 7 days once is total to dispenser 2 times.Investigated respectively the powdery mildew of cucumber disease index and calculated preventive effect in 7 days, 14 days after for the second time dispenser.Experimental result is as follows:
Table 8 contains the bactericidal composition of tridemorph and prevents and treats the powdery mildew of cucumber test of pesticide effectiveness
As can be seen from Table 8, can effectively prevent and treat powdery mildew of cucumber after tridemorph and methoxy acrylic bactericide are composite, control efficiency all is better than contrasting medicament, and the lasting period is long.In the test scope of medication target crop is had no adverse effects, preventive effect reaches more than 90%.Find simultaneously, tridemorph and methoxy acrylic bactericide are composite also to have preferably preventive effect afterwards to cucumber anthracnose, downy mildew, all reaches more than 90%.
Embodiment uses four: the bactericidal composition that contains tridemorph is prevented and treated the apple mildew test of pesticide effectiveness
This experimental establishment is at Liquan County, Shaanxi Province footpath between fields Dong Zhen, and test medicine is researched and developed, provided by Shaanxi agricultural chemicals Co., Ltd of U.S. nation; Contrast medicament: 250g/L Fluoxastrobin suspending agent (commercial), 50% water dispersion granules agent of Kresoxim (commercial), 25% pyraclostrobin missible oil (commercial), 5% alkene oxime amine missible oil (commercial), 25% oxime bacterium emulsifiable concentrate (commercial), 25% Enestroburin missible oil (commercial), 10% ZJ0712 suspending agent (commercial), 750g/L tridemorph missible oil (commercial).
The investigation apple mildew state of an illness before the medicine, in for the first time dispenser of state of an illness initial stage, dispenser in per 7 days once is total to dispenser 3 times.Investigated respectively the apple mildew disease index and calculated preventive effect in 7 days, 14 days after the dispenser for the third time.Experimental result is as follows:
Table 9 contains the bactericidal composition of tridemorph and prevents and treats the apple mildew test of pesticide effectiveness
As can be seen from Table 9, can effectively prevent and treat apple mildew after tridemorph and methoxy acrylic bactericide are composite, control efficiency all is better than contrasting medicament, and the lasting period is long.In the test scope of medication target crop is had no adverse effects, preventive effect reaches more than 90%.Find simultaneously, tridemorph and methoxy acrylic bactericide are composite also to have good preventive effect afterwards to apple canker, all reaches more than 90%.
Embodiment uses five: the bactericidal composition that contains tridemorph is prevented and treated the wheat rust test of pesticide effectiveness
This experimental establishment is at Hua County, Henan Province Cui Jiacun, and test medicine is researched and developed, provided by Shaanxi agricultural chemicals Co., Ltd of U.S. nation; Contrast medicament: 250g/L Fluoxastrobin suspending agent (commercial), 50% water dispersion granules agent of Kresoxim (commercial), 25% pyraclostrobin missible oil (commercial), 5% alkene oxime amine missible oil (commercial), 25% oxime bacterium emulsifiable concentrate (commercial), 25% Enestroburin missible oil (commercial), 10% ZJ0712 suspending agent (commercial), 750g/L tridemorph missible oil (commercial).
The investigation wheat rust state of an illness before the medicine, in for the first time dispenser of their early stage, dispenser in per 7 days once is total to dispenser 2 times.Investigated respectively the wheat rust disease index and calculated preventive effect in 7 days, 14 days after for the second time dispenser.Experimental result is as follows:
Table 10 contains the bactericidal composition of tridemorph and prevents and treats the wheat rust test of pesticide effectiveness
As can be seen from Table 10, can effectively prevent and treat wheat rust after tridemorph and methoxy acrylic bactericide are composite, control efficiency all is better than contrasting medicament, and the lasting period is long.In the test scope of medication target crop is had no adverse effects, preventive effect reaches more than 90%.Find simultaneously, tridemorph and methoxy acrylic bactericide are composite also to have preferably preventive effect afterwards to wheat powdery mildew.
Embodiment uses six: the bactericidal composition that contains tridemorph is prevented and treated the sigatoka test of pesticide effectiveness
This experimental establishment is in LongXi, Fujian Province county, and test medicine is researched and developed, provided by Shaanxi agricultural chemicals Co., Ltd of U.S. nation; Contrast medicament: 250g/L Fluoxastrobin suspending agent (commercial), 50% water dispersion granules agent of Kresoxim (commercial), 25% pyraclostrobin missible oil (commercial), 5% alkene oxime amine missible oil (commercial), 25% oxime bacterium emulsifiable concentrate (commercial), 25% Enestroburin missible oil (commercial), 10% ZJ0712 suspending agent (commercial), 750g/L tridemorph missible oil (commercial).
The investigation sigatoka state of an illness before the medicine, in for the first time dispenser of state of an illness initial stage, dispenser in per 7 days once is total to dispenser 3 times.Investigated respectively the sigatoka disease index and calculated preventive effect in 7 days, 14 days after the dispenser for the third time.Experimental result is as follows:
Table 9 contains the bactericidal composition of tridemorph and prevents and treats the sigatoka test of pesticide effectiveness
Claims (7)
1. bactericidal composition that contains tridemorph, it is characterized in that: the effective active composition tridemorph of bactericidal composition and the weight ratio of ZJ0712 are 32 ︰, 1～1 ︰ 16.
2. the bactericidal composition that contains tridemorph according to claim 1, it is characterized in that: the weight ratio of effective active composition tridemorph and ZJ0712 is 16 ︰, 1～1 ︰ 16.
3. the bactericidal composition that contains tridemorph according to claim 2, it is characterized in that: the weight ratio of effective active composition tridemorph and ZJ0712 is 16 ︰, 1～1 ︰ 4.
4. the bactericidal composition that contains tridemorph according to claim 1, it is characterized in that: the effective active component content accounts for 1～80% of gross weight.
5. the bactericidal composition that contains tridemorph according to claim 4, it is characterized in that: the effective active component content accounts for 10～50% of gross weight.
6. the bactericidal composition that contains tridemorph according to claim 1 is characterized in that: bactericidal composition is used for preventing and treating the application of disease due to Ascomycetes, Basidiomycetes and the Fungi Imperfecti germ.
7. application according to claim 6 is characterized in that: described disease comprises powdery mildew, rust, rot, anthracnose, leaf spot, downy mildew.
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4914128A (en) * | 1985-12-20 | 1990-04-03 | Basf Aktiengesellschaft | Acrylates and fungicides which contain these compounds |
| CN1456054A (en) * | 2003-03-25 | 2003-11-19 | 浙江省化工研究院 | Methoxy methyl acrylate compounds as bactericidal agent |
| CN1915019A (en) * | 2005-08-17 | 2007-02-21 | 浙江化工科技集团有限公司 | Composition of bactericide |
| CN101669495A (en) * | 2009-08-23 | 2010-03-17 | 山东兆丰年生物科技有限公司 | Bactericidal composition containing kresoxim-methyl phenylate |
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Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4914128A (en) * | 1985-12-20 | 1990-04-03 | Basf Aktiengesellschaft | Acrylates and fungicides which contain these compounds |
| CN1456054A (en) * | 2003-03-25 | 2003-11-19 | 浙江省化工研究院 | Methoxy methyl acrylate compounds as bactericidal agent |
| CN1915019A (en) * | 2005-08-17 | 2007-02-21 | 浙江化工科技集团有限公司 | Composition of bactericide |
| CN101669495A (en) * | 2009-08-23 | 2010-03-17 | 山东兆丰年生物科技有限公司 | Bactericidal composition containing kresoxim-methyl phenylate |
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