CN102885764A - New preparation method of acetylcysteine gel - Google Patents
New preparation method of acetylcysteine gel Download PDFInfo
- Publication number
- CN102885764A CN102885764A CN2012104393852A CN201210439385A CN102885764A CN 102885764 A CN102885764 A CN 102885764A CN 2012104393852 A CN2012104393852 A CN 2012104393852A CN 201210439385 A CN201210439385 A CN 201210439385A CN 102885764 A CN102885764 A CN 102885764A
- Authority
- CN
- China
- Prior art keywords
- gel
- acetylcysteine
- triethanolamine
- water
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- PWKSKIMOESPYIA-BYPYZUCNSA-N L-N-acetyl-Cysteine Chemical compound CC(=O)N[C@@H](CS)C(O)=O PWKSKIMOESPYIA-BYPYZUCNSA-N 0.000 title claims abstract description 20
- 229960004308 acetylcysteine Drugs 0.000 title claims abstract description 14
- 238000002360 preparation method Methods 0.000 title claims abstract description 11
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 12
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 11
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 claims abstract description 9
- 239000007788 liquid Substances 0.000 claims abstract description 8
- 238000003756 stirring Methods 0.000 claims abstract description 7
- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 claims abstract description 5
- 238000002156 mixing Methods 0.000 claims abstract description 5
- QELSKZZBTMNZEB-UHFFFAOYSA-N propylparaben Chemical compound CCCOC(=O)C1=CC=C(O)C=C1 QELSKZZBTMNZEB-UHFFFAOYSA-N 0.000 claims abstract description 5
- 239000008215 water for injection Substances 0.000 claims abstract description 5
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims abstract description 4
- 229920002125 Sokalan® Polymers 0.000 claims abstract description 4
- 229960001631 carbomer Drugs 0.000 claims abstract description 4
- 235000010270 methyl p-hydroxybenzoate Nutrition 0.000 claims abstract description 4
- 239000004292 methyl p-hydroxybenzoate Substances 0.000 claims abstract description 4
- 229960002216 methylparaben Drugs 0.000 claims abstract description 4
- 239000000203 mixture Substances 0.000 claims abstract description 4
- 235000010232 propyl p-hydroxybenzoate Nutrition 0.000 claims abstract description 4
- 239000004405 propyl p-hydroxybenzoate Substances 0.000 claims abstract description 4
- 239000002253 acid Substances 0.000 claims description 6
- 239000003172 expectorant agent Substances 0.000 claims description 6
- ZGTMUACCHSMWAC-UHFFFAOYSA-L EDTA disodium salt (anhydrous) Chemical compound [Na+].[Na+].OC(=O)CN(CC([O-])=O)CCN(CC(O)=O)CC([O-])=O ZGTMUACCHSMWAC-UHFFFAOYSA-L 0.000 claims description 3
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 3
- BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 claims description 3
- 229910000397 disodium phosphate Inorganic materials 0.000 claims description 3
- 235000019800 disodium phosphate Nutrition 0.000 claims description 3
- 239000012467 final product Substances 0.000 claims description 3
- 229910000403 monosodium phosphate Inorganic materials 0.000 claims description 3
- 235000019799 monosodium phosphate Nutrition 0.000 claims description 3
- 238000007254 oxidation reaction Methods 0.000 claims description 3
- 229910052708 sodium Inorganic materials 0.000 claims description 3
- 239000011734 sodium Substances 0.000 claims description 3
- AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical compound [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 claims description 3
- HRZFUMHJMZEROT-UHFFFAOYSA-L sodium disulfite Chemical compound [Na+].[Na+].[O-]S(=O)S([O-])(=O)=O HRZFUMHJMZEROT-UHFFFAOYSA-L 0.000 claims description 3
- 235000010262 sodium metabisulphite Nutrition 0.000 claims description 3
- 230000008961 swelling Effects 0.000 claims description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 abstract 3
- 239000003814 drug Substances 0.000 abstract 2
- 239000000758 substrate Substances 0.000 abstract 2
- KEAYESYHFKHZAL-UHFFFAOYSA-N Sodium Chemical compound [Na] KEAYESYHFKHZAL-UHFFFAOYSA-N 0.000 abstract 1
- 229960003415 propylparaben Drugs 0.000 abstract 1
- 239000002552 dosage form Substances 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 102000008186 Collagen Human genes 0.000 description 1
- 108010035532 Collagen Proteins 0.000 description 1
- 102000029816 Collagenase Human genes 0.000 description 1
- 108060005980 Collagenase Proteins 0.000 description 1
- 230000004098 cellular respiration Effects 0.000 description 1
- 229960002424 collagenase Drugs 0.000 description 1
- 239000002442 collagenase inhibitor Substances 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- 210000003560 epithelium corneal Anatomy 0.000 description 1
- 230000002061 histotrophic effect Effects 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 230000035764 nutrition Effects 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 230000008929 regeneration Effects 0.000 description 1
- 238000011069 regeneration method Methods 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
Landscapes
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention provides a new preparation method of acetylcysteine gel. The preparation method disclosed by the invention comprises the steps of: evenly mixing acetylcysteine with sodium hydroxide, natrium adetate and the like, dissolving methyl paraben and propyl paraben with water for injection and then adding into the uniformly-mixed mixture to obtain liquid medicine; preparing a gel substrate from carbomer, glycerol and triethanolamine; slowly adding the liquid medicine to the gel substrate and continuously stirring, adjusting pH is with triethanolamine, adding the water for injection until a particular amount is reached, and evenly mixing, so as to obtain the acetylcysteine gel the quality of which meets the requirements. The acetylcysteine gel prepared by the preparation method meets the requirements in identification, content and other aspects, and the product quality is effectively guaranteed.
Description
Technical field
The present invention relates to medical technical field, disclose a kind of preparation method of new mucolyticum acid gel.
Background technology
Acetylcysteine, the chemical name ACETYLCYSTEINE, chemical structural formula:
Acetylcysteine is white crystalline powder, and the foul smell of similar Bulbus Allii is arranged.Acetylcysteine is collagenase inhibitors, directly irreversibly suppresses collagenase, reduces the decomposition of collagen protein in the tissue.In addition, acetylcysteine can improve Cellular respiration and histotrophic nutrition, promotes regeneration of corneal epithelium, improves the eye metabolism.
The invention provides a kind of new acetylcysteine dosage form, filled up this blank.
Goal of the invention
The present invention has provided a kind of preparation method of new mucolyticum acid gel, to produce a new dosage form.
Summary of the invention
The invention provides a kind of preparation method of new mucolyticum acid gel.
The preparation method of new mucolyticum acid gel of the present invention is:
1, acetylcysteine hydro-oxidation sodium, disodium edetate, sodium pyrosulfite, sodium hydrogen phosphate, sodium dihydrogen phosphate mixing add methyl parahydroxybenzoate, propyl p-hydroxybenzoate in the above-mentioned homomixture with the water for injection dissolving, get medicinal liquid; Other gets carbomer and injects the abundant swelling of water, adds glycerol, drips triethanolamine and constantly stirring, gets gel-type vehicle; Medicinal liquid is slowly added in the gel-type vehicle, constantly stir, regulate pH value with triethanolamine, inject water to 1000g, mix homogeneously and get final product.
The specific embodiment
Further set forth the present invention below by example, but do not place restrictions on the present invention.
Embodiment one:
1, acetylcysteine 80g hydro-oxidation sodium 25g, disodium edetate 10g, sodium pyrosulfite 15g, sodium hydrogen phosphate 100g, sodium dihydrogen phosphate 20g mixing, methyl parahydroxybenzoate 10g, propyl p-hydroxybenzoate 5g are added in the above-mentioned homomixture with the water for injection dissolving, get medicinal liquid; Other gets carbomer 110g and injects the abundant swelling of water, adds glycerol 50g, drips triethanolamine and constantly stirring, gets gel-type vehicle; Medicinal liquid is slowly added in the gel-type vehicle, constantly stir, regulate pH value with triethanolamine, adding distil water is to 1000g, mix homogeneously and get final product.
Claims (2)
1. the preparation method of a new mucolyticum acid gel, it is characterized in that acetylcysteine hydro-oxidation sodium, disodium edetate, sodium pyrosulfite, sodium hydrogen phosphate, sodium dihydrogen phosphate mixing, methyl parahydroxybenzoate, propyl p-hydroxybenzoate are added in the above-mentioned homomixture with the water for injection dissolving, get medicinal liquid; Other gets carbomer and injects the abundant swelling of water, adds glycerol, drips triethanolamine and constantly stirring, gets gel-type vehicle; Medicinal liquid is slowly added in the gel-type vehicle, constantly stir, regulate PH5.5-7.0 with triethanolamine, it is an amount of to inject water, mix homogeneously and get final product.
2. according to claims 1 described preparation method, it is characterized in that the optimum range with triethanolamine adjusting pH value is 6.3-7.0 at pH value.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2012104393852A CN102885764A (en) | 2012-11-02 | 2012-11-02 | New preparation method of acetylcysteine gel |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2012104393852A CN102885764A (en) | 2012-11-02 | 2012-11-02 | New preparation method of acetylcysteine gel |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN102885764A true CN102885764A (en) | 2013-01-23 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2012104393852A Pending CN102885764A (en) | 2012-11-02 | 2012-11-02 | New preparation method of acetylcysteine gel |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN102885764A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104739854A (en) * | 2013-12-30 | 2015-07-01 | 天津高科生产力促进有限公司 | Compound gargle of NAC and chitosan |
| CN104739758A (en) * | 2013-12-30 | 2015-07-01 | 天津高科生产力促进有限公司 | N- acetyl-L-cysteine gargle |
| CN107049826A (en) * | 2017-03-24 | 2017-08-18 | 徐州医科大学 | A kind of external preparation with formalin buffer action |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5707635A (en) * | 1991-10-16 | 1998-01-13 | Richardson-Vicks Inc. | Gel type cosmetic compositions |
| CN101367947A (en) * | 2007-08-14 | 2009-02-18 | 南开大学 | Biocompatible natural polymer hydrogel and preparation method |
| WO2009137827A2 (en) * | 2008-05-09 | 2009-11-12 | Tiara Pharmaceuticals, Inc. | Controlled release of n-acetylcysteine (nac) for reduction of systemic and/or vascular inflammation |
| CN101947211A (en) * | 2010-08-28 | 2011-01-19 | 浙江金华康恩贝生物制药有限公司 | Method for preparing acetylcysteine effervescent tablet |
-
2012
- 2012-11-02 CN CN2012104393852A patent/CN102885764A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5707635A (en) * | 1991-10-16 | 1998-01-13 | Richardson-Vicks Inc. | Gel type cosmetic compositions |
| CN101367947A (en) * | 2007-08-14 | 2009-02-18 | 南开大学 | Biocompatible natural polymer hydrogel and preparation method |
| WO2009137827A2 (en) * | 2008-05-09 | 2009-11-12 | Tiara Pharmaceuticals, Inc. | Controlled release of n-acetylcysteine (nac) for reduction of systemic and/or vascular inflammation |
| CN101947211A (en) * | 2010-08-28 | 2011-01-19 | 浙江金华康恩贝生物制药有限公司 | Method for preparing acetylcysteine effervescent tablet |
Non-Patent Citations (2)
| Title |
|---|
| 李毅敏 等: "N-乙酰半胱氨酸的研究进展", 《天津药学》, vol. 15, no. 2, 30 April 2003 (2003-04-30), pages 50 - 53 * |
| 程天贵: "乙酰半胱氨酸制剂与临床应用研究进展", 《中国生化药物杂志》, vol. 28, no. 6, 31 December 2007 (2007-12-31), pages 430 - 432 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104739854A (en) * | 2013-12-30 | 2015-07-01 | 天津高科生产力促进有限公司 | Compound gargle of NAC and chitosan |
| CN104739758A (en) * | 2013-12-30 | 2015-07-01 | 天津高科生产力促进有限公司 | N- acetyl-L-cysteine gargle |
| CN107049826A (en) * | 2017-03-24 | 2017-08-18 | 徐州医科大学 | A kind of external preparation with formalin buffer action |
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| PB01 | Publication | ||
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| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
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Application publication date: 20130123 |