CN102872233A - Oral preparation contributed to improving gastrointestinal function - Google Patents
Oral preparation contributed to improving gastrointestinal function Download PDFInfo
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- CN102872233A CN102872233A CN2012103931256A CN201210393125A CN102872233A CN 102872233 A CN102872233 A CN 102872233A CN 2012103931256 A CN2012103931256 A CN 2012103931256A CN 201210393125 A CN201210393125 A CN 201210393125A CN 102872233 A CN102872233 A CN 102872233A
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- gastrointestinal function
- constipation
- oral preparation
- improving gastrointestinal
- oligo saccharide
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Abstract
The invention relates to an oral preparation, in particular to an oral preparation contributed to improving gastrointestinal function, aiming at solving the problems that the laxative drugs prepared in the prior art are high in side effect, cause dependence after being taken for a long time and are harmful to the health. The oral preparation contributed to improving gastrointestinal function is prepared from soybean oligosaccharide, fructus cannabis, bunge cherry seeds and mulberries. The oral preparation contributed to improving gastrointestinal function has the advantages that raw materials are easy to obtain, the preparation is convenient to prepare, has mild function, is capable of nourishing instead of diarrhoea, less in irritation and has small possibility of dependence, thus being suitable for industrial production.
Description
Technical field
The present invention relates to a kind of oral formulations.
Background technology
(constipation means that difficult defecation, defecation frequency that a variety of causes causes reduce or defecation is felt not to the utmost in constipation.In recent years, because the quickening of rhythm of life, the change of dietary structure, the in addition intestinal flora imbalance that causes of antibiotic unreasonable application, constipation has become the very common a kind of disease of modern metropolitan cities people, has had a strong impact on modern's quality of life.
France national gastroenterology's continuing education (CME) chairman Philippe professor Houcke claims, is one of very common patient main suit in French constipation, and the case of annual diagnosis can reach 4,500,000 person-times.Medical college Satish S.C associate professor Rao of U.S. Iowa university has then reported the constipation latest survey result of the U.S.: the sick rate of the constipation of U.S.'s mid-aged population is: the women 17%, and the male 12%.The correlation study result of China shows that Beijing, Tianjin and the crowd of area, Xi'an more than 60 years old chronic constipation prevalence is up to 15%～20%; Beijing adult's chronic constipation prevalence is about 6%, and this index of women is more than 4 times of male.
Long-term clinical research and practice are verified, constipation is huge on healthy impact, because the excrement block length time is detained intestinal, abnormal fermentation, produce a large amount of toxin, easily give birth to acne, erythra etc., the diseases such as the also concurrent insomnia of possibility, dysmenorrhea, colon cancer, breast carcinoma, presenile dementia have a strong impact on Quality of Life.Treatment constipation common drug and dietetic therapy way solve at present, although certain curative effect is arranged, but treat all not thorough, also produce with zest and side effect in the process of some Drug therapys, therefore long-term taking has dependency, develops a kind of taking convenience, safe and effective relieving constipation product is the needs in market.
According to the retrieval, soybean oligo saccharide and other Chinese medicinal components are not yet arranged as the loosening bowel to relieve constipation medicine of raw material at present.
Summary of the invention
The constipation relieving and the intestine moistening drug side effect that the objective of the invention is in order to solve the prior art preparation is large, long-term taking has dependency, to healthy disadvantageous problem, and provide that a kind of raw material is easy to get, prepares conveniently, action temperature and, mend and do not let out, zest is little, is difficult for forming the dependent oral formulations that improves gastrointestinal function.
A kind of oral formulations that helps to improve gastrointestinal function of the present invention is to be made by 8 ~ 12 parts soybean oligo saccharide, 5 ~ 10 parts Fructus Cannabis, 1 ~ 5 part Semen Pruni and 1 ~ 5 part Fructus Mori by weight.
The pharmacology of each crude drug and drug effect in the component of the present invention:
1, soybean oligo saccharide: the general name of soluble oligosaccharide in the Semen sojae atricolor mainly comprises stachyose, cottonseed sugar and sucrose.To be that the daily Semen sojae atricolor that eats is refining form soybean oligo saccharide, non-chemically synthetic.Its effect mainly is the foodstuff that becomes the enteral bacillus bifidus, the quantity that increases bacillus bifidus.
The health-care effect of soybean oligo saccharide: the 1. clean intestinal of relieving constipation: constipation patient is because enteral lacks due to the bacillus bifidus mostly, old people especially, and with age, the enteral bacillus bifidus reduces gradually and very easily suffers from constipation.Evidence, Healthy People absorbs 3 gram soybean oligo saccharide every day, just can promote bifidobacterium growth, produces defecating feces excretion, and soybean oligo saccharide can also promote enterokinesia to accelerate to drain.2. promote bacillus bifidus propagation in the intestinal: prove through experimentation, take in 10 ~ 15 gram soybean oligo saccharide every day, bacillus bifidus can be increased to 45% by original 0.99% after 17 days.Bacillus bifidus in the intestinal very easily utilizes soybean oligo saccharide, produces acetic acid, lactic acid and some antibiotics materials, thereby suppresses the propagation of exogenous pathogenic bacterium and enteral Putrefying bacteria; Bacillus bifidus also can by phosphatidic acid and intestinal mucosa surface, form the biomembrane barrier that one deck has protective effect, thereby the prevention harmful microbe be invaded and surely be grown.3. reduce serum cholesterol: a large amount of human experimentations has confirmed to take in the level that can reduce serum cholesterol behind the soybean oligo saccharide, takes in 6 ~ 12 gram soybean oligo saccharide every day and continues 2 thoughtful 3 months, and the total serum cholesterol can obviously reduce.4. assist and reduce blood pressure: find by human experimentation, the tested patient of hypertension takes in 11.5 gram soybean oligo saccharide every day, after continuing for 5 weeks, the ratio that the quantity of bacillus bifidus accounts for total bacteria in the height of human body diastolic pressure and its feces becomes obvious negative, this shows that soybean oligo saccharide can reach the effect that reduces blood pressure by the propagation that promotes bacillus bifidus.5. the liver protecting: human body can reduce the generation of toxic metabolite material in the body by the long-term soybean oligo saccharide of taking in, and alleviates the burden of liver detoxification, produces the mutual inductance effect, and the hepatopathys such as hepatitis and liver cirrhosis are all had prophylactic-therapeutic effect.Experiment shows, allows elderly patients that suffered from liver cirrhosis in 69 years old take soybean oligo saccharide 3 grams every day, and its hepatic coma and constipation symptom are all alleviated to some extent after 5 days.
2, Fructus Cannabis: property is sweet, and is flat.Return spleen, stomach, large intestine channel.Fructus Cannabis is used as medicine has long history in China, and all book on Chinese herbal medicine thinks that all Fructus Cannabis is loosening bowel to relieve constipation and have the medicine of the effect of taking a tonic or nourishing food to build up one's health concurrently simply.Modern study shows, the fatty oil of Fructus Cannabis, protein, mineral and multivitamin.Because fatty oil can be moisturized laxation, so traditional Chinese medical science Fructus Cannabis commonly used is treated constipation due to dry stool, be particularly useful for treating the withered constipation in old people's blood deficiency Tianjin.In addition, such as weak long-pending after being ill with heat, and the dryness of the intestine constipation patient of the withered insufficiency of blood in Tianjin in puerperal, be suitable for equally taking it.
3, Semen Pruni: property is hot, bitter, sweet, and is flat.Return stomach, large intestine, small intestine meridian.Function cures mainly as moisturizing laxation, the therapeutic method to keep the adverse QI flowing downwards, diuretic.Be used for intestine-dryness due to consumption of fluid, stagnation of QI due to dyspepsia, abdominal distention constipation, edema, beriberi, dysuria.
4, Fructus Mori: the YIN nourishing of enriching blood, promote the production of body fluid and moisturize.Be used for vertigo and tinnitus, palpitation and insomnia, early whitening of beard and hair, Tianjin wound is thirsty, and interior-heat is quenched one's thirst, blood deficiency and constipation.Tonifying liver, kidney tonifying relieves dizziness, high fever, infantile convulsions, epilepsy, etc., and grows liquid.Control hepatic and renal YIN deficiency, quench one's thirst, constipation, order is dark, tinnitus, scrofula, articular instability.
Fructus Cannabis in the component of the present invention, sweet, put down, return spleen, stomach, large intestine channel, can loosening bowel to relieve constipation, be the treatment blood deficiency and depleted fluid, the key medicine of dryness of the intestine constipation is monarch drug in the component of the present invention." medicineization justice " speech: " the body profit can be gone dry for Fructus Cannabis, energy intestine moistening, and the patent large intestine is depressed just to be closed.All old blood is uninteresting, and puerperal, QI and blood had some setbacks, and vigour is not multiple after being ill, or can not move all a little less than reporting and control." Semen Pruni is hot, bitter, sweet, flat.Return spleen, large intestine channel.Can moisturize laxation, be to be ministerial drug." Bencao Jingshu " said: " Semen Pruni, property is specially fallen, the kind dry stool retained in large intestine of leading ".The monarch and his subjects' compatibility is used, and Fructus Cannabis enters edema caused by disorder of QI partially, and downhill race circulation of qi promoting, relieving constipation are rushed down lower, two medicine compatibilities, and QI and blood is also transferred, and profit is just rushed down lower.The Fructus Mori nature and flavor are sweet, acid is cold, GUIXIN, liver, kidney channel." Bencao Jingshu " " the sweet cold beneficial blood of Fructus Mori and heat extraction are the enrich blood medicine of tonifying YIN of removing heat from blood ", we are with its YIN nourishing of enriching blood, the liver nourishing kidney tonifying, Fructus Mori is promoted the production of body fluid and moisturizes, and is adjuvant drug.The multiplication agent that adds again bacillus bifidus---soybean oligo saccharide is adjusted from the basic reason of constipation, makes the symptom of constipation obtain improving comparatively thoroughly.
The oral formulations that helps to improve gastrointestinal function of the present invention has following beneficial effect:
1, adopts pure natural extract soybean oligo saccharide for mainly containing effective constituent, the proliferation of probiotics factor is provided, improved intestinal environment when increasing intestinal motive force, fundamentally adjust the constipation symptom, safety, effective.
2, Fructus Cannabis, Semen Pruni all are the Chinese medicine of integration of edible and medicinal herbs, two medicine compatibilities, QI and blood is also transferred, profit is just rushed down lower, action temperature and, zest is little, is difficult for forming dependency, is suitable for habitual and senile constipation person.
The specific embodiment
Technical solution of the present invention is not limited to the following cited specific embodiment, also comprises the combination in any between each specific embodiment.
The specific embodiment one: the oral formulations that present embodiment a kind of helps to improve gastrointestinal function is to be made by 8 ~ 12 parts soybean oligo saccharide, 5 ~ 10 parts Fructus Cannabis, 1 ~ 5 part Semen Pruni and 1 ~ 5 part Fructus Mori by weight.
The oral formulations with functions of loosening bowel relieving constipation of present embodiment has following beneficial effect:
1, adopts pure natural extract soybean oligo saccharide for mainly containing effective constituent, the proliferation of probiotics factor is provided, improved intestinal environment when increasing intestinal motive force, fundamentally adjust the constipation symptom, safety, effective.
2, Fructus Cannabis, Semen Pruni all are the Chinese medicine of integration of edible and medicinal herbs, two medicine compatibilities, QI and blood is also transferred, profit is just rushed down lower, action temperature and, zest is little, is difficult for forming dependency, is suitable for habitual and senile constipation person.
Soybean oligo saccharide in the present embodiment is bought from Wuhan large magnificent great achievement medication chemistry company limited.
Oral formulations in the present embodiment comprises granule, tablet, capsule and liquid preparation.
The specific embodiment two: the oral formulations that present embodiment is a kind of to help to improve gastrointestinal function is to be made by 10 parts soybean oligo saccharide, 9 parts Fructus Cannabis, 3 parts Semen Pruni and 3 parts Fructus Mori by weight.
Soybean oligo saccharide in the present embodiment is bought from Wuhan large magnificent great achievement medication chemistry company limited.
By following verification experimental verification beneficial effect of the present invention:
This test a kind of helps to improve the preparation method of the oral formulations of gastrointestinal function and carries out according to the following steps:
With the Fructus Cannabis of 9g, the Semen Pruni of 3g, the Fructus Mori of 3g, add 10 times of water gagings and decoct 2 times, get water extract; Water extract is condensed into thick paste, vacuum dehydrating at lower temperature, is ground into fine powder or is spray dried to fine powder, mix with the 10g soybean oligo saccharide, add 3g starch and 2g dextrin, make 20g dose every day, obtain helping to improve the granule of gastrointestinal function.
With the Fructus Cannabis of 9g, the Semen Pruni of 3g, the Fructus Mori of 3g, add 10 times of water gagings and decoct 2 times, get water extract; Then add the 10g soybean oligo saccharide in the water extract and fully dissolve, add again proper honey, make 20mL dose every day, obtain helping to improve the oral liquid of gastrointestinal function.
Administering mode: the oral liquid that helps to improve gastrointestinal function that this test is made, by one day 2 times, the dosage of each 10mL gives the patient and takes, the granule that helps to improve gastrointestinal function that perhaps this test is made, by one day 2 times, the dosage of each 10g gives the patient and takes, and patient's disease and therapeutic outcome are as shown in table 1.
The above-mentioned clinical experiment presentation of results oral formulations that helps to improve gastrointestinal function of the present invention has good loosening bowel to relieve constipation curative effect, and total effective rate reaches 100%.
Claims (2)
1. oral formulations that helps to improve gastrointestinal function, the oral formulations that it is characterized in that helping improving gastrointestinal function is to be made by 8 ~ 12 parts soybean oligo saccharide, 5 ~ 10 parts Fructus Cannabis, 1 ~ 5 part Semen Pruni and 1 ~ 5 part Fructus Mori by weight.
2. a kind of oral formulations that helps to improve gastrointestinal function according to claim 1, the oral formulations that it is characterized in that helping improving gastrointestinal function is to be made by 10 parts soybean oligo saccharide, 9 parts Fructus Cannabis, 3 parts Semen Pruni and 3 parts Fructus Mori by weight.
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| CN2012103931256A CN102872233A (en) | 2012-10-17 | 2012-10-17 | Oral preparation contributed to improving gastrointestinal function |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106036318A (en) * | 2016-06-12 | 2016-10-26 | 中国食品发酵工业研究院 | Asparagus fermented beverage capable of improving intestinal functions and method for preparing asparagus fermented beverage |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1555849A (en) * | 2004-01-12 | 2004-12-22 | 洁 钱 | Intestine moistening oral liquid and its preparation method |
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- 2012-10-17 CN CN2012103931256A patent/CN102872233A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1555849A (en) * | 2004-01-12 | 2004-12-22 | 洁 钱 | Intestine moistening oral liquid and its preparation method |
Non-Patent Citations (2)
| Title |
|---|
| 《中国实用医药》 20090930 李本楠等 "大豆低聚糖理化性质及其生理功能" 238-239 1-2 第4卷, 第25期 * |
| 李本楠等: ""大豆低聚糖理化性质及其生理功能"", 《中国实用医药》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106036318A (en) * | 2016-06-12 | 2016-10-26 | 中国食品发酵工业研究院 | Asparagus fermented beverage capable of improving intestinal functions and method for preparing asparagus fermented beverage |
| CN106036318B (en) * | 2016-06-12 | 2019-11-12 | 中国食品发酵工业研究院有限公司 | A kind of asparagus fermented beverage and preparation method thereof that can improve function of intestinal canal |
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Application publication date: 20130116 |