CN102827441A - Cooling gel sheet - Google Patents
Cooling gel sheet Download PDFInfo
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- CN102827441A CN102827441A CN2012102227345A CN201210222734A CN102827441A CN 102827441 A CN102827441 A CN 102827441A CN 2012102227345 A CN2012102227345 A CN 2012102227345A CN 201210222734 A CN201210222734 A CN 201210222734A CN 102827441 A CN102827441 A CN 102827441A
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- temperature
- cooling
- patch according
- cellulose ether
- polyvinyl alcohol
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- 238000001816 cooling Methods 0.000 title claims abstract description 24
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 23
- NIXOWILDQLNWCW-UHFFFAOYSA-N 2-Propenoic acid Natural products OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims abstract description 14
- 239000003999 initiator Substances 0.000 claims abstract description 10
- 239000004372 Polyvinyl alcohol Substances 0.000 claims abstract description 7
- 229920002451 polyvinyl alcohol Polymers 0.000 claims abstract description 7
- 230000035945 sensitivity Effects 0.000 claims abstract description 6
- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 claims abstract 4
- 229920003086 cellulose ether Polymers 0.000 claims abstract 4
- 239000003431 cross linking reagent Substances 0.000 claims abstract 4
- RTZKZFJDLAIYFH-UHFFFAOYSA-N ether Substances CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims description 19
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 16
- 229920000881 Modified starch Polymers 0.000 claims description 15
- 229920002678 cellulose Polymers 0.000 claims description 13
- 235000010980 cellulose Nutrition 0.000 claims description 13
- 238000007710 freezing Methods 0.000 claims description 12
- 230000008014 freezing Effects 0.000 claims description 12
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims description 8
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims description 8
- 229910052757 nitrogen Inorganic materials 0.000 claims description 8
- 238000006116 polymerization reaction Methods 0.000 claims description 8
- 239000000243 solution Substances 0.000 claims description 8
- 238000003756 stirring Methods 0.000 claims description 8
- 239000001913 cellulose Substances 0.000 claims description 7
- USHAGKDGDHPEEY-UHFFFAOYSA-L potassium persulfate Chemical compound [K+].[K+].[O-]S(=O)(=O)OOS([O-])(=O)=O USHAGKDGDHPEEY-UHFFFAOYSA-L 0.000 claims description 7
- WFDIJRYMOXRFFG-UHFFFAOYSA-N Acetic anhydride Chemical compound CC(=O)OC(C)=O WFDIJRYMOXRFFG-UHFFFAOYSA-N 0.000 claims description 5
- ROOXNKNUYICQNP-UHFFFAOYSA-N ammonium persulfate Chemical compound [NH4+].[NH4+].[O-]S(=O)(=O)OOS([O-])(=O)=O ROOXNKNUYICQNP-UHFFFAOYSA-N 0.000 claims description 4
- 239000007864 aqueous solution Substances 0.000 claims description 3
- FPYJFEHAWHCUMM-UHFFFAOYSA-N maleic anhydride Chemical compound O=C1OC(=O)C=C1 FPYJFEHAWHCUMM-UHFFFAOYSA-N 0.000 claims description 3
- 238000002360 preparation method Methods 0.000 claims description 3
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 claims 1
- 229910001870 ammonium persulfate Inorganic materials 0.000 claims 1
- 239000001863 hydroxypropyl cellulose Substances 0.000 claims 1
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 claims 1
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims 1
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims 1
- 229920000609 methyl cellulose Polymers 0.000 claims 1
- -1 methyl cellulose ethers Chemical class 0.000 claims 1
- 239000001923 methylcellulose Substances 0.000 claims 1
- 235000010981 methylcellulose Nutrition 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 17
- 230000004044 response Effects 0.000 abstract description 2
- 229920002472 Starch Polymers 0.000 abstract 1
- 239000003292 glue Substances 0.000 abstract 1
- 239000008107 starch Substances 0.000 abstract 1
- 235000019698 starch Nutrition 0.000 abstract 1
- 239000000499 gel Substances 0.000 description 26
- 239000000017 hydrogel Substances 0.000 description 13
- 238000006243 chemical reaction Methods 0.000 description 11
- 238000000034 method Methods 0.000 description 10
- 239000003814 drug Substances 0.000 description 9
- 239000007788 liquid Substances 0.000 description 9
- 239000004159 Potassium persulphate Substances 0.000 description 6
- 239000003795 chemical substances by application Substances 0.000 description 6
- 239000011505 plaster Substances 0.000 description 6
- 235000019394 potassium persulphate Nutrition 0.000 description 6
- 239000012141 concentrate Substances 0.000 description 5
- 229940079593 drug Drugs 0.000 description 5
- NIXOWILDQLNWCW-UHFFFAOYSA-M Acrylate Chemical compound [O-]C(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-M 0.000 description 4
- CGIGDMFJXJATDK-UHFFFAOYSA-N indomethacin Chemical compound CC1=C(CC(O)=O)C2=CC(OC)=CC=C2N1C(=O)C1=CC=C(Cl)C=C1 CGIGDMFJXJATDK-UHFFFAOYSA-N 0.000 description 4
- 238000010438 heat treatment Methods 0.000 description 3
- 239000010410 layer Substances 0.000 description 3
- 239000002346 layers by function Substances 0.000 description 3
- 238000002156 mixing Methods 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- DTGKSKDOIYIVQL-WEDXCCLWSA-N (+)-borneol Chemical compound C1C[C@@]2(C)[C@@H](O)C[C@@H]1C2(C)C DTGKSKDOIYIVQL-WEDXCCLWSA-N 0.000 description 2
- REPVLJRCJUVQFA-UHFFFAOYSA-N (-)-isopinocampheol Natural products C1C(O)C(C)C2C(C)(C)C1C2 REPVLJRCJUVQFA-UHFFFAOYSA-N 0.000 description 2
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 description 2
- 201000010000 Agranulocytosis Diseases 0.000 description 2
- 239000004160 Ammonium persulphate Substances 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 208000032843 Hemorrhage Diseases 0.000 description 2
- 244000246386 Mentha pulegium Species 0.000 description 2
- 235000016257 Mentha pulegium Nutrition 0.000 description 2
- 235000004357 Mentha x piperita Nutrition 0.000 description 2
- 235000019395 ammonium persulphate Nutrition 0.000 description 2
- 230000001754 anti-pyretic effect Effects 0.000 description 2
- 239000002221 antipyretic Substances 0.000 description 2
- 208000006673 asthma Diseases 0.000 description 2
- 230000003796 beauty Effects 0.000 description 2
- 229940116229 borneol Drugs 0.000 description 2
- CKDOCTFBFTVPSN-UHFFFAOYSA-N borneol Natural products C1CC2(C)C(C)CC1C2(C)C CKDOCTFBFTVPSN-UHFFFAOYSA-N 0.000 description 2
- DTGKSKDOIYIVQL-UHFFFAOYSA-N dl-isoborneol Natural products C1CC2(C)C(O)CC1C2(C)C DTGKSKDOIYIVQL-UHFFFAOYSA-N 0.000 description 2
- 230000008020 evaporation Effects 0.000 description 2
- 238000001704 evaporation Methods 0.000 description 2
- 210000001061 forehead Anatomy 0.000 description 2
- 235000001050 hortel pimenta Nutrition 0.000 description 2
- 229960000905 indomethacin Drugs 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- YLGXILFCIXHCMC-JHGZEJCSSA-N methyl cellulose Chemical compound COC1C(OC)C(OC)C(COC)O[C@H]1O[C@H]1C(OC)C(OC)C(OC)OC1COC YLGXILFCIXHCMC-JHGZEJCSSA-N 0.000 description 2
- 210000003205 muscle Anatomy 0.000 description 2
- 229960005489 paracetamol Drugs 0.000 description 2
- 229940023462 paste product Drugs 0.000 description 2
- RMMXTBMQSGEXHJ-UHFFFAOYSA-N Aminophenazone Chemical compound O=C1C(N(C)C)=C(C)N(C)N1C1=CC=CC=C1 RMMXTBMQSGEXHJ-UHFFFAOYSA-N 0.000 description 1
- BSYNRYMUTXBXSQ-UHFFFAOYSA-N Aspirin Chemical compound CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- 229920002749 Bacterial cellulose Polymers 0.000 description 1
- 206010018687 Granulocytopenia Diseases 0.000 description 1
- 101000607872 Homo sapiens Ubiquitin carboxyl-terminal hydrolase 21 Proteins 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- HEFNNWSXXWATRW-UHFFFAOYSA-N Ibuprofen Chemical compound CC(C)CC1=CC=C(C(C)C(O)=O)C=C1 HEFNNWSXXWATRW-UHFFFAOYSA-N 0.000 description 1
- 206010067125 Liver injury Diseases 0.000 description 1
- 208000007271 Substance Withdrawal Syndrome Diseases 0.000 description 1
- 102100039918 Ubiquitin carboxyl-terminal hydrolase 21 Human genes 0.000 description 1
- 201000000839 Vitamin K Deficiency Bleeding Diseases 0.000 description 1
- 206010047634 Vitamin K deficiency Diseases 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 231100000570 acute poisoning Toxicity 0.000 description 1
- 230000000172 allergic effect Effects 0.000 description 1
- 230000007815 allergy Effects 0.000 description 1
- 229960000212 aminophenazone Drugs 0.000 description 1
- 230000000202 analgesic effect Effects 0.000 description 1
- 208000010668 atopic eczema Diseases 0.000 description 1
- 239000005016 bacterial cellulose Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- SVPXDRXYRYOSEX-UHFFFAOYSA-N bentoquatam Chemical compound O.O=[Si]=O.O=[Al]O[Al]=O SVPXDRXYRYOSEX-UHFFFAOYSA-N 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 230000000740 bleeding effect Effects 0.000 description 1
- 230000036760 body temperature Effects 0.000 description 1
- 210000004958 brain cell Anatomy 0.000 description 1
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- 239000002131 composite material Substances 0.000 description 1
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- 239000003205 fragrance Substances 0.000 description 1
- 238000003304 gavage Methods 0.000 description 1
- 231100000234 hepatic damage Toxicity 0.000 description 1
- 231100000652 hormesis Toxicity 0.000 description 1
- 230000002631 hypothermal effect Effects 0.000 description 1
- 229960001680 ibuprofen Drugs 0.000 description 1
- 230000002427 irreversible effect Effects 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 230000008818 liver damage Effects 0.000 description 1
- 229920002521 macromolecule Polymers 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 238000000465 moulding Methods 0.000 description 1
- 210000005036 nerve Anatomy 0.000 description 1
- 231100000957 no side effect Toxicity 0.000 description 1
- 239000004745 nonwoven fabric Substances 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 239000002985 plastic film Substances 0.000 description 1
- 229920006255 plastic film Polymers 0.000 description 1
- 239000003507 refrigerant Substances 0.000 description 1
- 239000012266 salt solution Substances 0.000 description 1
- 230000035807 sensation Effects 0.000 description 1
- 238000007493 shaping process Methods 0.000 description 1
- GOLXNESZZPUPJE-UHFFFAOYSA-N spiromesifen Chemical compound CC1=CC(C)=CC(C)=C1C(C(O1)=O)=C(OC(=O)CC(C)(C)C)C11CCCC1 GOLXNESZZPUPJE-UHFFFAOYSA-N 0.000 description 1
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- Medicinal Preparation (AREA)
- Thermotherapy And Cooling Therapy Devices (AREA)
- Polymerisation Methods In General (AREA)
Abstract
本发明公开了一种降温贴，由以下重量百分比的组分构成：丙烯酸1-3%，具有温敏性的非离子型纤维素醚0.05-0.3%，聚乙烯醇3-6%，预胶化淀粉0.3-1%，交联剂0.05-0.3%，引发剂0.05-0.3%，水余量。本发明具有快速响应的温度敏感性，可以达到快速降温的效果，本产品安全可靠，完全依靠物理降温。
The invention discloses a cooling patch, which is composed of the following components in weight percentage: 1-3% of acrylic acid, 0.05-0.3% of non-ionic cellulose ether with temperature sensitivity, 3-6% of polyvinyl alcohol, pre-glue Starch 0.3-1%, cross-linking agent 0.05-0.3%, initiator 0.05-0.3%, water balance. The invention has the temperature sensitivity of quick response, and can achieve the effect of rapid cooling. The product is safe and reliable, and completely relies on physical cooling.
Description
Technical field
The invention belongs to medicochemistry article compositions field, relate in particular to a kind of temperature-reducing paste.
Background technology
Clinical cooling measure commonly used mainly contains two kinds, and a kind of is Physical temperature-lowering, and a kind of is drug cooling.Any cool-down method of concrete application should decide according to patient's age, physique and the degree of heat.Drug cooling has advantages such as effect is obvious, method of use is simple; In clinical; Antipyretic and analgesic commonly used at present has Frosst) (Xaxa), Paracetamol USP23,BP98 (PARACETAMOL BP98), INDOMETHACIN BP99 (indomethacin), Ibuprofen BP/EP etc.; But these Side effects of pharmaceutical drugs are surprising or irreversible to the liver kidney and the gastral infringement of infant, and drug cooling has a lot of contraindications, as: there is the patient of antipyretic allergies should forbid febrifugee; Also should be prudent when the patient of allergic constitution uses febrifugee; Serious liver damage, vitamin K deficiency person, haemophiliac and have the patient of asthma history should avoid the use of Frosst), in case hemorrhage with bring out asthma; Pyramidon can cause agranulocytosis, and period in a medicine is as finding granulocytopenia drug withdrawal immediately.So febrifugee can not be taken for a long time, otherwise can cause acute and chronic poisoning.General body temperature below 39 ℃ preferably without drug cooling.
Traditional physical cooling method has: 1. watch-keeping cubicle warm therapy; 2. 34 ~ 35 ℃ of warm water or 30 ℃ of 25% ~ 30% ethanol songe bath method; 3. ice compress method; 4. icy salt solution bowel lavage or administration by gavage; 5. hypothermic blanket continues falling temperature method; 6. vein falling temperature method etc.Above cool-down method has been widely used in clinical by the doctor, played different cooling-down effects.But above method is more loaded down with trivial details, and what have also can cause toxic side effects.
Novel physical cooling method mainly refers to high-molecular gel temperature-reducing paste falling temperature method; Its cool principle is the evaporation through moisture in its staple hydrogel; Take away the human heat, thereby reach the purpose of local cooling, the cooling-down effect of product depends primarily on the moisture content in the hydrogel.This series products does not need refrigerating apparatus, does not need setup time, unpacks during use, leans on viscosity own to be affixed on forehead or other positions, and it is comparatively convenient to use.[Chinese invention patent 201020583841.7] provides a kind of cooling paster of measurable temperature, is made up of non-woven fabrics, hydrogel and plastics film, it is characterized in that hydrogel is divided into different temperature zones, and temperature-sensitive colour changing thermal indicutor sheet is arranged in each temperature zone.But there are many defectives in present existing temperature-reducing paste product, and is generally shorter like temperature fall time, is generally about 2-3 hour, and only for once using, increased patient's use cost virtually; Existing temperature-reducing paste is many to carry out auxiliary temperature-reducing through adding traditional Chinese medicine ingredients such as peppermint, borneol; This type traditional Chinese medicine ingredients is through stimulating human nerve; Make the people produce refrigerant sensation; But really do not play the effect that reduces the temperature protection brain cell, and these pharmaceutical cpds there are bigger hormesis to eye and wound, make troubles to the patient easily during use.[Chinese invention patent 201020239963.4] relates to a kind of reusable bacterial cellulose hydrogel temperature-reducing plaster, comprises macromolecule membrane layer and bacteria cellulose aquagel functional layer.[Chinese invention patent 200720192944.9] relates to a kind of Physical temperature-lowering and pastes; Comprise nonwoven layer, plastic film layers and hydrophilic high molecular material functional layer, it is characterized in that being mixed with in the hydrophilic high molecular material functional layer peppermint and/or borneol natural phant elite.
Therefore, have that a kind of production technique is simple, no side effects, easy to use, the temperature-reducing paste product demand fast of lowering the temperature.
In addition; High according to water-soluble cooling paster because of water cut; Can take away human heat's characteristics rapidly; Its Application Areas is also in continuous expansion, has been applied to alleviating pain, refreshment, relaxs one's muscles, improves sleep, fields such as medicine, sports goods, beauty treatment, articles for daily use such as skin moisture-keeping beauty treatment.
Summary of the invention
The objective of the invention is to propose a kind of temperature-reducing paste of temperature with high efficiency easily and fast.
The present invention adopts following technical scheme to achieve these goals:
A kind of temperature-reducing paste is characterized in that: be made up of following components in weight percentage:
Vinylformic acid 1-3%
Non-ionic celluloses ether 0.05-0.3% with temperature sensitive property
Z 150PH 3-6%
Pregelatinized Starch 0.3-1%
Linking agent 0.05-0.3%
Initiator 0.05-0.3%
Water surplus;
The preparation method may further comprise the steps:
(1) adds initiator by mass percentage in the aqueous solution of mixing by mass percentage to the non-ionic celluloses ether with temperature sensitive property and vinylformic acid; Under nitrogen protection, descend reaction after 8-12 minute in 35-40 ℃; Add the linking agent stirring reaction by mass percentage after 5-6 hour, the liquid concentrator of Mierocrystalline cellulose/acrylate/nano gel;
(2) with Z 150PH and pregelatinized Starch clear soln that is mixed with soluble in water under microwave-assisted, again to the liquid concentrator that wherein adds Mierocrystalline cellulose/acrylate/nano gel, poured into behind the mould freezing 2-3 hour, repeated freezing 2-5 time promptly gets.
Described a kind of temperature-reducing paste is characterized in that: described linking agent refers to a kind of in N ' N-methylene-bisacrylamide, diacetyl oxide, the MALEIC ANHYDRIDE.
Described a kind of temperature-reducing paste is characterized in that: described initiator refers to Potassium Persulphate or ammonium persulphate.
Described a kind of temperature-reducing paste is characterized in that: described non-ionic celluloses ether with temperature sensitive property refers to a kind of in HPMC ether, hydroxypropylcelluloether ether, the methyl cellulose ether.
Described a kind of temperature-reducing paste is characterized in that: the described Z 150PH polymerization degree is 1350-2050.
Described a kind of temperature-reducing paste is characterized in that: the temperature of described freezing operation is not for being higher than-12 ℃.
Described a kind of temperature-reducing paste is characterized in that: described microwave-assisted operation refers to Z 150PH and pregelatinized Starch soluble in water, puts into microwave reactor reaction 5-10 second again.
Principle of the present invention is:
Polyvinyl alcohol hydrogel of the present invention has excellent biological compatibility, can not cause any stimulation or sense of discomfort to human body skin, is fit to children's and uses.Z 150PH can replace with Expex, has good swelling property and water-retentivity equally.
Pregelatinized Starch of the present invention is used for improving the molding time and the shaping strength of polyvinyl alcohol hydrogel.
Temperature-reducing paste of the present invention can contain flavouring agent to bring the various fragrance of a flower or fruit smell to product, makes child patient be easy to receive treatment.
These article are not limited to as the Physical temperature-lowering product, can be used for alleviating pain, refreshment equally, relax one's muscles, improve sleep, etc. fields such as medicine, sports goods, articles for daily use.
Beneficial effect of the present invention: advantage of the present invention is; Lower critical solution temperature with HPMC/ROHM composite Nano gel of temperature sensitivity is 38 ℃, when children's's forehead temperature is higher than 38 ℃, and bleeding; Moisture evaporation in the hydrogel is taken away the heat of human body; When temperature is lower than 38 ℃, the gel swelling once again that absorbs water, thus realize reusable.The present invention has the temperature sensitivity of quick response, can reach the effect of fast cooling.This product safety is reliable, relies on Physical temperature-lowering fully.
Description of drawings
Fig. 1 is the sign collection of illustrative plates of the present invention under transmission electron microscope;
Fig. 2 is for testing cooling-down effect figure of the present invention with the anthropomorphic temperature of thermostatically heating template die;
Fig. 3 is the cooling-down effect comparison diagram of ordinary gel paster and paster of the present invention.
Embodiment
Non-limiting examples is narrated as follows:
Embodiment 1, get 0.4 g HPMC and 8.0 g vinylformic acid are dissolved in the 90 ml zero(ppm) water; Add 0.35 g Potassium Persulphate then; Charge into nitrogen; Temperature rises to 38 ℃, and preheating adds 0.35 g N ' N-methylene-bisacrylamide after 10 minutes, and stirring reaction must be received the liquid concentrator of gel in 5 hours; Getting 4.5 g Z 150PH (polymerization degree is 1950) and 0.65 g pregelatinized Starch then is dissolved under microwave assistant in the 75 ml zero(ppm) water; Fully after the dissolving; The gel concentrate of receiving of getting 25 ml adds in this solution, cold slightly after, pour into and put into refrigerated tank (15 ℃) in the mould and thaw after freezing 2.5 hours; Circulate 2 times, must contain and receive the hydrogel temperature-reducing plaster of gel.
Fig. 2 is cooling-down effect figure---with the anthropomorphic temperature test of thermostatically heating template die cooling-down effect; Temperature-reducing paste placed respectively on 37 ℃, 38 ℃, 39 ℃ the thermostatically heating plate; Measured the temperature of the temperature-constant plate (being temperature-reducing paste and temperature-constant plate contact surface) under the temperature-reducing paste in per 10 minutes respectively, test constantly 180 min.Shown in accompanying drawing 2, X-coordinate is the attaching time, and ordinate zou is measured temperature.From scheme, can draw, when the temperature-constant plate temperature was 38 ℃ of left and right sides before subsides were used, paste with temperature decline obvious (about 33.5 ℃) behind 10 min; Paste with about 34.5 ℃ of local temperatures behind 30 min, paste and weaken about 35 ℃ of local temperatures with cooling-down effect behind 1 h gradually; In 3 hours working lipe, the temperature of temperature-constant plate less than 38 ℃ of beginning, explains that temperature-reducing paste plays cooling effect always always; Compare with other two groups, cooling-down effect is obvious.
Fig. 3 receives the cooling-down effect figure of cooling paster of gel for the ordinary gel paster with containing, and from figure, can find out significantly that the ordinary gel paster does not have cooling-down effect basically.
Embodiment 2, get 0.45 g HPMC and 7.2 g vinylformic acid are dissolved in the 90 ml zero(ppm) water; Add 0.4 g Potassium Persulphate then; Charge into nitrogen; Temperature rises to 38 ℃, and preheating adds 0.4 g N ' N-methylene-bisacrylamide after 10 minutes, and stirring reaction must be received the liquid concentrator of gel in 6 hours; Getting 4.8 g Z 150PH (polymerization degree is 1800) and 0.8 g pregelatinized Starch then is dissolved under microwave assistant in the 70 ml zero(ppm) water; Fully after the dissolving; The gel concentrate of receiving of getting 25 ml adds in this solution, cold slightly after, pour into and put into refrigerated tank (20 ℃) in the mould and thaw after freezing two hours; Circulate 2 times, must contain and receive the hydrogel temperature-reducing plaster of gel.
Embodiment 3, get 0.4 g HPMC, 0.35 g MALEIC ANHYDRIDE and 8.0 g vinylformic acid mixing solutionss and be dissolved in the 90 ml zero(ppm) water; Add 0.35 g ammonium persulphate then; Charge into nitrogen, temperature rises to 38 ℃, and stirring reaction must be received the liquid concentrator of gel in 5 hours; Getting 5 g Z 150PH (polymerization degree is 1750) and 0.6 g pregelatinized Starch then is dissolved under microwave assistant in the 75 ml zero(ppm) water; Fully after the dissolving; The gel concentrate of receiving of getting 25 ml adds in this solution, cold slightly after, pour into and put into refrigerated tank (12 ℃) in the mould and thaw after freezing 3 hours; Circulate 3 times, must contain and receive the hydrogel temperature-reducing plaster of gel.
Embodiment 4, get 0.4 g HPMC and 6.0 g vinylformic acid are dissolved in the 90 ml zero(ppm) water; Add 0.4 g Potassium Persulphate then; Charge into nitrogen; Temperature rises to 38 ℃, and preheating adds 0.4 g N ' N-methylene-bisacrylamide after 10 minutes, and stirring reaction must be received the liquid concentrator of gel in 5 hours; Getting 4.5 g Z 150PH (polymerization degree is 1950) and 0.6 g pregelatinized Starch then is dissolved under microwave assistant in the 75 ml zero(ppm) water; Fully after the dissolving; The gel concentrate of receiving of getting 25 ml adds in this solution, cold slightly after, pour into and put into refrigerated tank (15 ℃) in the mould and thaw after freezing 2.5 hours; Circulate 2 times, must contain and receive the hydrogel temperature-reducing plaster of gel.
Embodiment 5, get 0.38 g HPMC and 6.8 g vinylformic acid are dissolved in the 90 ml zero(ppm) water; Add 0.35 g Potassium Persulphate then; Charge into nitrogen; Temperature rises to 38 ℃, and preheating adds 0.35 g N ' N-methylene-bisacrylamide after 10 minutes, and stirring reaction must be received the liquid concentrator of gel in 5 hours; Getting 5 g Z 150PH (polymerization degree is 1850) and 0.65 g pregelatinized Starch then is dissolved under microwave assistant in the 75 ml zero(ppm) water; Fully after the dissolving; The gel concentrate of receiving of getting 25 ml adds in this solution, cold slightly after, pour into and put into refrigerated tank (20 ℃) in the mould and thaw after freezing 2 hours; Circulate 2 times, must contain and receive the hydrogel temperature-reducing plaster of gel.
Embodiment 6, a kind of temperature-reducing paste are made up of following components in weight percentage:
Vinylformic acid 1%
Non-ionic celluloses ether 0.3% with temperature sensitive property
Z 150PH 3%
Pregelatinized Starch 1%
Linking agent 0.3%
Initiator 0.3%
Water surplus;
The preparation method may further comprise the steps:
(1) adds initiator by mass percentage in the aqueous solution of mixing by mass percentage to the non-ionic celluloses ether with temperature sensitive property and vinylformic acid; Under nitrogen protection, descend reaction after 10 minutes in 40 ℃; Add the linking agent stirring reaction by mass percentage after 5 hours, the liquid concentrator of Mierocrystalline cellulose/acrylate/nano gel;
(2) with Z 150PH and pregelatinized Starch clear soln that is mixed with soluble in water under microwave-assisted, again to the liquid concentrator that wherein adds Mierocrystalline cellulose/acrylate/nano gel, poured into behind the mould freezing 2 hours, freeze cycle 2 times promptly gets.
Described linking agent refers to diacetyl oxide.
Described initiator refers to Potassium Persulphate.
Described non-ionic celluloses ether with temperature sensitive property refers to methyl cellulose ether.
The described Z 150PH polymerization degree is 2050.
The temperature of described freezing operation is-18 ℃.
Described microwave-assisted operation refers to Z 150PH and pregelatinized Starch soluble in water, puts into microwave reactor reaction 10 seconds again.
Claims (7)
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| WO2018097425A1 (en) * | 2016-11-28 | 2018-05-31 | 롯데정밀화학 주식회사 | Method for manufacturing porous hydrogel sheet, and porous hydrogel sheet manufactured by manufacturing method |
| CN108276613A (en) * | 2017-12-29 | 2018-07-13 | 佛山市锦彤企业管理有限公司 | A kind of deep drawing quality macromolecule hydrogel |
| CN108276720A (en) * | 2017-12-29 | 2018-07-13 | 佛山市锦彤企业管理有限公司 | It is a kind of to stablize temperature sensitive antimicrobial macromolecule hydrogel |
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4472542A (en) * | 1982-08-13 | 1984-09-18 | Nippon Oil Co., Ltd. | Freeze-dried polyvinyl alcohol gel |
| CN101095634A (en) * | 2007-07-12 | 2008-01-02 | 长春吉原生物科技有限公司 | Temperature-reducing paste and method of manufacturing the same |
| CN102440979A (en) * | 2010-09-30 | 2012-05-09 | 迪特克(济源)绿色生物科技有限公司 | Cellulose derivative composite membrane and preparation method thereof |
-
2012
- 2012-06-30 CN CN201210222734.5A patent/CN102827441B/en not_active Expired - Fee Related
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4472542A (en) * | 1982-08-13 | 1984-09-18 | Nippon Oil Co., Ltd. | Freeze-dried polyvinyl alcohol gel |
| CN101095634A (en) * | 2007-07-12 | 2008-01-02 | 长春吉原生物科技有限公司 | Temperature-reducing paste and method of manufacturing the same |
| CN102440979A (en) * | 2010-09-30 | 2012-05-09 | 迪特克(济源)绿色生物科技有限公司 | Cellulose derivative composite membrane and preparation method thereof |
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