CN102813204A - Process for processing fermented ginseng extract - Google Patents
Process for processing fermented ginseng extract Download PDFInfo
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- CN102813204A CN102813204A CN201210327706XA CN201210327706A CN102813204A CN 102813204 A CN102813204 A CN 102813204A CN 201210327706X A CN201210327706X A CN 201210327706XA CN 201210327706 A CN201210327706 A CN 201210327706A CN 102813204 A CN102813204 A CN 102813204A
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Abstract
A process for processing fermented ginseng extract comprises the following steps of ginseng extract supply, wherein different ginseng raw materials include ginseng extract, red ginseng extract, American ginseng extract, stem leaf extract; fermentation, wherein the inoculum size of leuconostoc mesenteroides and the inoculum size of lactobacillus plantarum are respectively 3% and 1% by mass, the pH is 5.2-6.2, the fermentation temperature is 30-40 DEG C, and the fermentation time is 120-150 hours; secondary fermentation, wherein the inoculum size of leuconostoc mesenteroides is 2% by mass ratio, the pH is 5.2-6.2, the fermentation temperature is 30-40 DEG C, and the fermentation time is 48-72 hours; The process for processing the fermented ginseng extract is quick in absorption, small in dosage, quick in effect production and free of toxic and side effects.
Description
Technical field
The invention belongs to field of health care food, be specifically related to a kind of smart processing technology of ginseng of fermenting.
Background technology
Genseng is araliaceae ginseng plant's a dry root.Underground and the aerial part of genseng contains multiple physiologically active ingredient, and ginsenoside is an active ingredient main in the genseng, also is the most significant material of physiologically active.Isolated more than 30 kind of ginsenoside at present; Ginsenoside can divide the three major types crowd; The Rb group comprises Rao, Ra1, Ra2, Ra3, Rb1, Rb2, Rb3, Rc, Rd etc., and the Rg group comprises Re, Rg1, Rg2, Rg3, Rh1, Rh2 etc. and Ro group, and wherein sapogenin is respectively panoxadiol, panaxatriol and oleanolic acid; Rb group is stronger with Rg group physiologically active, Ro organize physiologically active a little less than.All separate the saponin(e that obtains from genseng all be that tetracyclic triterpene carries one to five glycan molecule that does not wait except that Ro; Result of study shows recently: ginsenoside is that the glucoside of parent is decomposed into the very strong metabolite of physiologically active under the effect of gut flora and enzyme with protopanoxadiol and Protopanaxatriol; And the physiologically active of ginsenoside prototype a little less than; Contain two molecular saccharides such as the ginsenoside Rg1; Metabolism is Rh1 (sloughing a part sugar) and PPt (sloughing two molecular saccharides) under the effect of gut flora and enzyme in vivo, and Rg1 prototype and metabolite Rh1, PPt has identical nootropic effect; But the effect of Rh1 and PPt obviously is better than Rg1, and is the strongest with final metabolite PPt effect.Utilizing ginsenoside to slough glycan molecule in vivo under the effect of gut flora and enzyme, to change into the very strong metabolite of biologically active theoretical; Developed pickle lactic acid bacteria fermentation and the fermented ginseng goods processed, fermented ginseng cosmetics etc. in Japan, Korea S; The elementary processed goods of the ginseng product of our domestic production is more at present; Production technology falls behind, the wasting of resources is more serious, should make full use of rich in natural resources and develop the product high in technological content, that added value is high audaciously.
Summary of the invention
The objective of the invention is provides a kind of fermentation ginseng fine-processing technique that fast, few dosage is also seen big effect, had no side effect that absorbs in order to address the above problem.
The present invention is achieved in that
A kind of smart processing technology of ginseng of fermenting may further comprise the steps:
(1) processing ginseng is smart: with the raw material ginseng put in the extractor once, secondary, add respectively for three times, four times 70%-60%, 50%-40%, 30%-20% and water purification under 80 ℃ of conditions per hour wink ring extracted 8 hours or 6 hours in 10 minutes.Separate in cooling after extraction finishes, the center of circle, cryogenic vacuum is evaporated to solid content and reaches the ginseng essence more than 60%, detects the content of Rb1, Rg1, Rg3 and Rh2 then with HPLC.
(2) dilution and sterilization: get the ginseng finishing water purification of solid content more than 60% and be diluted to 15% ginseng essence, sterilization is 15 minutes under 100 ℃ of conditions.
(3) one time fermentation: bright beading coccus of goldbeater's skin and Lactobacillus plantarum inoculum concentration are respectively 3%, 1% of mass fraction ratio, and pH is 5.2-6.2, and fermentation temperature is 30-40 ℃, and fermentation time is 120-150 hour;
(4) secondary fermentation: according to the one time fermentation situation confirm whether the carrying out of secondary fermentation (promptly get-inferior zymotic fluid 200mL adds 50%-60% edible alcohol 200mL, and to precipitate, filter, be concentrated into the fermentation ginseng of solid content more than 60% smart in the laboratory; Before the content that detects Rb1, Rg1, Rg3 and Rh2 with HPLC then and the fermentation testing result each other relatively the back confirm whether secondary fermentation carries out) concrete true mode is that the inoculum concentration of the bright beading coccus of goldbeater's skin is 2% of a mass fraction ratio; PH is 5.2-6.2; Fermentation temperature is 30-40 ℃, and fermentation time is 48-72 hour.
(5) fermentation ginseng is smart: (v/v) 50%-60% edible alcohol precipitates to add 1: 1 in the fermentation ends after fermentation liquid, carries out then that the center of circle is separated, the cryogenic vacuum decompression concentrates and obtain solid content and reach the fermentation ginseng essence 60% or more.Through the content of HPLC detection Rb1, Rg1, Rg3 and Rh2, relatively experimental data before and after the fermentation.
Rb1, Rg1, Rg3, Rh2 content (%) before and after the smart fermentation of red ginseng
| The ginsenoside Rb1 | The ginsenoside Rg1 | Ginseng sapoglycoside Rg 3 | Ginseng saponin Rh 2 | |
| Before the fermentation | 0.86 | 0.72 | ＜0.1 | ＜0.1 |
| One time fermentation | 0.48 | 0.43 | 0.29 | 0.52 |
| Secondary fermentation | 0.29 | 0.26 | 0.45 | 0.63 |
Characteristics of the present invention be through biological fermentation process make the lower material of biologically active change into the stronger material of biologically active, big molecule changes into little molecule; Thereby be prone to absorb, distribute; Few dosage is also seen big effect and is saved resource, increases the comprehensive utilization ratio of limited resources.
Fermented red ginseng essence of the present invention is following through clinical observation:
One, clinical data
Physical data: 90 routine men and women schoolboy's 70 examples among the student of taking an examination, schoolgirl's 20 examples are divided three groups at random.
Clinical indexes: concentrated force, adaptive faculty, endurance, sleep, appetite etc.
Two, eating method
First group of edible fermented red ginseng essence: early eat 1 time ante cibum edible 2 times of every day, eat 1 time before sleeping.Each 1 spoonful (about 1.5 grams) take after mixing it with water with warm water.
Second group of edible red ginseng essence: early eat 1 time ante cibum edible 2 times of every day, eat 1 time before sleeping.Each 1 (about 1.5 grams) are taken after mixing it with water with warm water.
The 3rd group of edible red ginseng essence: early eat 1 time ante cibum edible 2 times of every day, eat 1 time before sleeping.Each 2 spoonfuls (about 3.0 grams) take after mixing it with water with warm water.
Three, observed result
Edible after one month, visible first group of personnel's instant effect is and lasting, and the 3rd group of personnel take effect slowly and lasting, and second group of personnel is not as first group and the 3rd group.In addition, in the clinical trial process, taking the smart effect of fermented red ginseng is identical with the effect of taking fermented ginseng essence, fermentation American Ginseng essence.
The specific embodiment
Embodiment 1
Get the above raw material ginseng of life in 4 years (sun-dried ginseng: genseng palpus=3: 7) 200 kilograms; Put in the extractor to divide and extract for four times, temperature and was extracted 8 hours or 6 hours with the mode that per hour circulated 10 minutes all under 80 ℃ of conditions when extracting at every turn; Used edible alcohol is 70% when extracting for the first time; Used edible alcohol is 50% when extracting for the second time, and used edible alcohol is to add water purification 30%, the four time when extracting for the third time; After extracting through four times; Separate in extract cooling, the center of circle, the cryogenic vacuum decompression concentrates, and the temperature when concentrating in the concentration tank is no more than 60 ℃, and vacuum is 0.07-0.08Mp; Obtaining solid content is the panax ginseng extractum more than 60%, detects the content of Rb1, Rg1, Rg3 and Rh2 then with HPLC.Getting 50 kilograms of panax ginseng extractums puts into and adds water purification in the fermentation tank and be diluted to 15% ginseng liquid; Ferment after 15 minutes in sterilization under 100 ℃ of conditions; Bright beading coccus of goldbeater's skin and Lactobacillus plantarum inoculum concentration are respectively 3%, 1% of mass fraction ratio when fermenting for the first time; PH is 5.2-6.2, and fermentation temperature is 30-40 ℃, and fermentation time is 120-150 hour.Getting for the first time one time fermentation liquid 200mL after the fermentation ends adds 50%-60% edible alcohol 200mL and precipitate, filters, is concentrated into the fermented ginseng essence of solid content more than 60% in the laboratory; The inoculum concentration of using testing result before content that HPLC detects Rb1, Rg1, Rg3 and Rh2 and the fermentation relatively need do the bright beading coccus of goldbeater's skin when fermenting for the second time each other then is 2% of mass fraction ratio; PH is 5.2-6.2; Fermentation temperature is 30-40 ℃, and fermentation time is 48-72 hour.Secondary fermentation finishes to add 1: 1 in the after fermentation liquid, and (v/v) 50%-60% edible alcohol precipitates; Carry out then that the center of circle is separated, the cryogenic vacuum decompression concentrates that to obtain the fermented ginseng that solid content reaches 60% or more smart, behind the content of HPLC detection Rb1, Rg1, Rg3 and Rh2, processes product.
The fermented ginseng essence is as goods such as semi-finished product processing and fermentation genseng soft capsule, fermented ginseng oral liquid, fermented ginseng lozenges.
Embodiment 2
Get 200 kilograms of 4 years above raw material red ginsengs of life; Put in the extractor to divide and extract for four times, temperature and was extracted 8 hours or 6 hours with the mode that per hour circulated 10 minutes all under 80 ℃ of conditions when extracting at every turn; Used edible alcohol is 60% when extracting for the first time; Used edible alcohol is 40% when extracting for the second time, and used edible alcohol is to add water purification 20%, the four time when extracting for the third time; After extracting through four times; Separate in extract cooling, the center of circle, the cryogenic vacuum decompression concentrates, and the temperature when concentrating in the concentration tank is no more than 60 ℃, and vacuum is 0.07-0.08Mp; Obtaining solid content is the red ginseng essence more than 60%, detects the content of Rb1, Rg1, Rg3 and Rh2 then with HPLC.Getting 50 kilograms of red ginseng essences puts into and adds water purification in the fermentation tank and be diluted to 15% red ginseng liquid; Ferment after 15 minutes in sterilization under 100 ℃ of conditions; Bright beading coccus of goldbeater's skin and Lactobacillus plantarum inoculum concentration are respectively 3%, 1% of mass fraction ratio when fermenting for the first time, and pH is 5.2-6.2, and fermentation temperature is 30-40 ℃; Fermentation time is 120-150 hour; Get for the first time one time fermentation liquid 200mL after the fermentation ends and add 50%-60% edible alcohol 200mL in the laboratory precipitate, filter, be concentrated into the fermented red ginseng of solid content 60% or more smart, the inoculum concentration of using content that HPLC detects Rb1, Rg1, Rg3 and Rh2 and the preceding testing result of fermentation relatively need do the bright beading coccus of goldbeater's skin when fermenting the second time each other then is 2% of mass fraction ratio, and pH is 5.2-6.2; Fermentation temperature is 30-40 ℃, and fermentation time is 48-72 hour.Secondary fermentation finishes to add 1: 1 in the after fermentation liquid, and (v/v) 50%-60% edible alcohol precipitates; Carry out then that the center of circle is separated, the cryogenic vacuum decompression concentrates that to obtain the fermented red ginseng that solid content reaches 60% or more smart, behind the content of HPLC detection Rb1, Rg1, Rg3 and Rh2, processes product.
The fermented red ginseng essence is as goods such as semi-finished product processing and fermentation red ginseng soft capsule, fermented red ginseng oral liquid, fermented red ginseng lozenges.
Embodiment 3
Get 200 kilograms of 4 years above raw material American Ginsengs of life; Put in the extractor to divide and extract for four times, temperature and was extracted 8 hours or 6 hours with the mode that per hour circulated 10 minutes all under 80 ℃ of conditions when extracting at every turn; Used edible alcohol is 70% when extracting for the first time; Used edible alcohol is 50% when extracting for the second time, and used edible alcohol is to add water purification 30%, the four time when extracting for the third time; After extracting through four times; Separate in extract cooling, the center of circle, the cryogenic vacuum decompression concentrates, and the temperature when concentrating in the concentration tank is no more than 60 ℃, and vacuum is 0.07-0.08Mp; Obtaining solid content is the American Ginseng essence more than 60%, detects the content of Rb1, Rg1, Rg3 and Rh2 then with HPLC.Getting 50 kilograms of American Ginseng essences puts into and adds water purification in the fermentation tank and be diluted to 15% american ginseng liquid; Ferment after 15 minutes in sterilization under 100 ℃ of conditions; Bright beading coccus of goldbeater's skin and Lactobacillus plantarum inoculum concentration are respectively 3%, 1% of mass fraction ratio when fermenting for the first time, and pH is 5.2-6.2, and fermentation temperature is 30-40 ℃; Fermentation time is 120-150 hour; Get for the first time one time fermentation liquid 200mL after the fermentation ends and add 50%-60% edible alcohol 200mL in the laboratory precipitate, filter, be concentrated into the fermentation American Ginseng of solid content 60% or more smart, the inoculum concentration of using content that HPLC detects Rb1, Rg1, Rg3 and Rh2 and the preceding testing result of fermentation relatively need do the bright beading coccus of goldbeater's skin when fermenting the second time each other then is 2% of mass fraction ratio, and pH is 5.2-6.2; Fermentation temperature is 30-40 ℃, and fermentation time is 48-72 hour.Secondary fermentation finishes to add 1: 1 in the after fermentation liquid, and (v/v) 50%-60% edible alcohol precipitates; Carry out then that the center of circle is separated, the cryogenic vacuum decompression concentrates that to obtain the fermentation American Ginseng that solid content reaches 60% or more smart, behind the content of HPLC detection Rb1, Rg1, Rg3 and Rh2, processes product.
Fermentation American Ginseng essence is as goods such as semi-finished product processing and fermentation American ginseng soft capsule, fermentation Oral Liquid Radix Panacis Quinquefolii, fermentation American ginseng buccal tablets.
Embodiment 4
Get 100 kilograms of 4 years above cauline leaf gensengs of life, put into branch second extraction in the extractor, temperature and was extracted 6 hours with the mode that per hour circulated 10 minutes all under 80 ℃ of conditions when extracting at every turn, added water purification at every turn; After the process second extraction; Separate in extract cooling, the center of circle, the cryogenic vacuum decompression concentrates; Temperature when concentrating in the concentration tank is no more than 60 ℃; Vacuum is 0.07-0.08Mp, and obtaining solid content is the cauline leaf panax ginseng extractum more than 60%, detects the content of Rb1, Rg1, Rg3 and Rh2 then with HPLC.Getting 30 kilograms of cauline leaf panax ginseng extractums puts into and adds water purification in the fermentation tank and be diluted to 15% cauline leaf ginseng liquid; Ferment after 15 minutes in sterilization under 100 ℃ of conditions; Bright beading coccus of goldbeater's skin and Lactobacillus plantarum inoculum concentration are respectively 3%, 1% of mass fraction ratio when fermenting for the first time, and pH is 5.2-6.2, and fermentation temperature is 30-40 ℃; Fermentation time is 120-150 hour; Get for the first time one time fermentation liquid 200mL after the fermentation ends and add 50%-60% edible alcohol 200mL in the laboratory precipitate, filter, be concentrated into the fermented ginseng of solid content 60% or more smart, the inoculum concentration of using content that HPLC detects Rb1, Rg1, Rg3 and Rh2 and the preceding testing result of fermentation relatively need do the bright beading coccus of goldbeater's skin when fermenting the second time each other then is 2% of mass fraction ratio, and pH is 5.2-6.2; Fermentation temperature is 30-40 ℃, and fermentation time is 48-72 hour.Secondary fermentation finishes to add 1: 1 in the after fermentation liquid, and (v/v) 50%-60% edible alcohol precipitates, and carries out then that the center of circle is separated, the cryogenic vacuum decompression concentrates and obtain solid content and reach the fermentation cauline leaf panax ginseng extractum more than 60%.
Fermentation cauline leaf panax ginseng extractum is processed goods such as series cosmetics, mildy wash, hair washing breast, bath foam, perfumed soap as semi-finished product.
Claims (5)
1. smart processing technology of ginseng of fermenting may further comprise the steps:
(1) providing of ginseng essence: smart in panax ginseng extractum, red ginseng essence, American Ginseng is smart and the cauline leaf panax ginseng extractum according to the difference ginseng of the raw material ginseng that is provided;
(2) fermentation:
(a) one time fermentation: bright beading coccus of goldbeater's skin and Lactobacillus plantarum inoculum concentration are respectively 3%, 1% of mass fraction ratio, and pH is 5.2-6.2, and fermentation temperature is 30-40 ℃, and fermentation time is 120-150 hour;
(b) secondary fermentation: the inoculum concentration of the bright beading coccus of goldbeater's skin is 2% of a mass fraction ratio, and pH is 5.2-6.2, and fermentation temperature is 30-40 ℃, and fermentation time is 48-72 hour.
2. a kind of smart processing technology of ginseng of fermenting according to claim 1 is characterized in that the smart solid content of described ginseng is more than 60%.
3. a kind of smart processing technology of ginseng of fermenting according to claim 1 is characterized in that described fermentation temperature is 30-40 ℃.
4. a kind of smart processing technology of ginseng of fermenting according to claim 1 is characterized in that described fermentation ginseng is smart in fermented ginseng is smart, fermented red ginseng is smart, the fermentation American Ginseng is smart and fermentation cauline leaf panax ginseng extractum.
5. a kind of smart processing technology of ginseng of fermenting according to claim 1 is characterized in that the smart solid content of described fermentation ginseng is more than 60%.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104544083A (en) * | 2015-01-19 | 2015-04-29 | 金日制药（中国）有限公司 | American ginseng fermented product and preparation method thereof |
| CN104585826A (en) * | 2015-01-19 | 2015-05-06 | 中国食品发酵工业研究院 | Ginseng fermentation product and preparation method thereof |
| CN104643062A (en) * | 2015-01-26 | 2015-05-27 | 邱芳萍 | American ginseng ferment |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1646150A (en) * | 2002-04-08 | 2005-07-27 | 弘林通产株式会社 | Novel use of the extract of processed ginseng and saponin isolated therefrom |
| CN101804086A (en) * | 2010-04-21 | 2010-08-18 | 许兰 | Preparation method of fermented red ginseng product |
-
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- 2012-08-27 CN CN201210327706XA patent/CN102813204A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1646150A (en) * | 2002-04-08 | 2005-07-27 | 弘林通产株式会社 | Novel use of the extract of processed ginseng and saponin isolated therefrom |
| CN101804086A (en) * | 2010-04-21 | 2010-08-18 | 许兰 | Preparation method of fermented red ginseng product |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104544083A (en) * | 2015-01-19 | 2015-04-29 | 金日制药（中国）有限公司 | American ginseng fermented product and preparation method thereof |
| CN104585826A (en) * | 2015-01-19 | 2015-05-06 | 中国食品发酵工业研究院 | Ginseng fermentation product and preparation method thereof |
| CN104585826B (en) * | 2015-01-19 | 2016-06-08 | 中国食品发酵工业研究院 | A kind of fermented ginseng goods and preparation method thereof |
| CN104643062A (en) * | 2015-01-26 | 2015-05-27 | 邱芳萍 | American ginseng ferment |
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