CN102809597A - Liquid resonance sensing method and system - Google Patents
Liquid resonance sensing method and system Download PDFInfo
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- CN102809597A CN102809597A CN2012102996130A CN201210299613A CN102809597A CN 102809597 A CN102809597 A CN 102809597A CN 2012102996130 A CN2012102996130 A CN 2012102996130A CN 201210299613 A CN201210299613 A CN 201210299613A CN 102809597 A CN102809597 A CN 102809597A
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Abstract
The invention discloses a liquid resonance sensing method and a system. The properties such as liquid viscoelasticity, density, composition, concentration and the like can be represented by liquid inherent frequency; liquid can generate resonance under the function of an alternating incentive oscillation signal; the resonance frequency changes accordingly when the liquid properties change; a sensor is a gold-film plated interdigital micro electrode and can be used for detecting the change of the liquid resonance frequency caused by the change of liquid viscoelasticity, density, composition and concentration; and specificity detection on a biochemical substance can be realized if the gold-film is modified with a biochemical function molecule. The sensing system consists of a resonance sensor 101, a driving oscillator 102, a vibration pickup 103, a single-chip microcomputer 104 and a computer 105. The system is simple in structure, can simultaneously detect the frequency change and the amplitude change of the sensor and an incentive response signal dynamic dissipative wave, and realize high accuracy and reliable detection of the liquid physical and chemical properties.
Description
Technical field
The invention belongs to sensing technology, biochemistry and physical technique field, be specifically related to a kind of liquid resonance sensor method and system.
Background technology
Resonance is a kind of phenomenon of extensive existence, machinery, chemistry, light, electricity and magnetic system and between each other all can observe resonance phenomena in the system of conversion process of energy.So far, people have set up the resonance theory of gaseous state and solid matter, and widespread use.In order to be familiar with the character of liquid; Current people adopt parameters such as density, concentration, pH value, viscoelasticity, conductivity and specific inductive capacity from different perspectives liquid to be characterized, and describe for Brownian movement then commonly used of the nonequilibrium process in the liquid and fluctuation etc.Any liquid all is made up of polar molecule or non-polar molecule; And molecule vibrates near corresponding equilibrium position; Its oscillation frequency and its " inwardness "---relating to parameters such as viscoelasticity, density, specific inductive capacity, composition and concentration, so oscillation frequency is characterizing the comprehensive inwardness of liquid.If in liquid, insert two electrodes, and apply with the alternation driving voltage, fluid molecule vibration meeting changes with the effect that adds alternating voltage.In the ordinary course of things; The amplitude amplitude of fluid molecule is very small; But when the frequency that adds alternating voltage was identical with the fluid molecule natural mode shape, then the amplitude of fluid molecule obviously strengthened, and is more much bigger than the amplitude under other frequency; We are called " liquid resonance " this phenomenon, and the resonance phenomena in it and LC loop has similarity.When " inwardness " of liquid was constant, its oscillation frequency was certain so.If the arbitrary character of liquid changes, then at this moment liquid has not been " originally liquid ", and its oscillation frequency is bound to change, and it is the combined reaction that liquid property changes.After the variation of the oscillation frequency of liquid, the electrode of available particular design can carry out resonance frequency through the design corresponding detecting system and measure.Thus; Under the environment of a sealing; Fixing when other parameter of liquid (like specific inductive capacity, conductivity, density, pH value etc.), only let some parameters change, the specific electrode that then adopts structural characteristic parameter to confirm; Can obtain owing to a certain parameter of liquid (like viscoelasticity) changes the liquid change of resonance frequency that causes, thereby usable resonance frequency characterizes the change of liquid " inwardness ".Because the interaction between fluid molecule is much littler than solid, so the liquid natural frequency is more vulnerable to the influence that liquid " inwardness " changes, cause the bigger variation of self frequency, act on piezoelectric crystal and cause that the piezoelectric frequency variation is much bigger than it.Therefore, in theory, characterize the liquid property variation with the liquid resonance frequency and have higher sensitivity.Thus, the present invention proposes a kind of method for sensing and system based on the liquid resonance mechanism.
Summary of the invention
The objective of the invention is to demand, a kind of novel liquid resonance sensor method and system is provided to the clinical medicine detection.Liquid resonance sensor method is set up based on the liquid resonance characteristic, utilizes the liquid resonance frequency to characterize the variation of liquid " inwardness ", the i.e. isoparametric variation of liquid viscoelasticity, density, specific inductive capacity, composition and concentration.Liquid resonance sensor system is made up of resonant transducer, signal excitation oscillation module, signals collecting and processing module and computing machine.System utilizes resonant transducer 201 as sensing unit; Driving oscillator 102 applies specific excited oscillation signal to resonant transducer; Pumping signal and liquid natural frequency produce resonance, and vibro-pickup 103 obtains resonance signal, and its corresponding hardware circuit obtains the frequency and the amplitude characteristic of resonance signal; Directly send frequency signal to single-chip microcomputer 104; Single-chip microcomputer 104 under institute's written program control, utilizes timer/counter can obtain the frequency values (Hz) of frequency signal under the standard second signal controlling; On the other hand,, convert voltage signal to, convert digital signal to through A/D converter and be input to single-chip microcomputer 104 through signal condition for the signal amplitude characteristic.The result liquor charging crystal display of single-chip microcomputer 104 shows in real time, and preserves accordingly result to storage unit, also can be sent to computing machine 105 through wave point and supply further Treatment Analysis, demonstration, storage and long-range to share etc.The excited oscillation signal that driving oscillator 102 sends can be adjusted according to vibro-pickup and single-chip microcomputer result.
Technical scheme of the present invention is following:
The liquid resonant transducer is on an insulation base, to make an interdigitation electrode (array) 201, the gold-plated film of electrode surface, and the thickness of this gold film is about 50-200nm.The single electrode that interdigital electrode is right can equivalence be the second order series resonance system, and its equivalent-circuit model is the circuit that comprises resistance R, inductance L and a capacitor C, and the sensor natural frequency is ω so
0=1/ (LC)
1/2Physical characteristics such as liquid viscoelasticity, density, dielectric property or liquid component and concentration thereof etc. change, and make the electrical characteristics of liquid produce respective change, and final general performance is the variation of liquid natural frequency.Then as exciting signal frequency ω=ω
0The time, liquid produces resonance phenomena, and parameters such as its resonance frequency and amplitude detect through external circuit.In order to improve selectivity and the sensitivity of sensor, can on golden film, solidify one deck again chemical constitution or biomolecule are had the sensitive layer that high degree of specificity combines specific biochemical component or biomolecule.
Liquid resonance sensor method and system involved in the present invention are utilized the liquid resonance principle; Based on the change of liquids physical chemistry characteristic and the variation of the liquid natural frequency that causes; Make liquid produce resonance through applying specific excited oscillation signal, come the physicochemical property of real-time tracer liquid through obtaining the liquid resonance frequency.Existing relatively detection technique, sensitivity of the present invention is higher, and detection method is more simple.To sensor array,, be easy to realize the detection of multiparameter physicochemical property in conjunction with multi-sensor information fusion technology.It is quick, convenient that sensor-based system detects; Not only can be applicable to the detection of physical parameters such as liquid viscoelasticity, density, specific inductive capacity; As hematologic disease and cardiovascular and cerebrovascular disease patients'blood coagulation process blood visco elasticity change in real time, in the body continuous monitoring; Also can realize specific detection at sensor electrode finishing different functions molecule to various diseases mark biochemical molecular.The signal data that sensor-based system obtains has multiple information parameter, like the exciter response signal dynamics dissipated wave of sensor after frequency, amplitude, the excited target etc., all can carry out analytical calculation by single-chip microcomputer, computing machine.The influence of physical characteristicss such as these different information parameter liquid body viscoelasticity, density, specific inductive capacity and biochemical substances composition and concentration etc.; Have different response results and relevance; It is multidimensional information; Through processing and analysis to this multidimensional information, with wherein arbitrarily one-dimension information all can obtain corresponding physics or chemical parameters.
Description of drawings
Fig. 1 is the sensor-based system structural representation
101 is resonant transducer among the figure; 102 is driving oscillator; 103 is vibro-pickup; 104 is single-chip microcomputer; 105 is computing machine;
Fig. 2 is the resonant transducer structural representation
201 is the single interdigital electrode of electrod-array among the figure; 202 is the interdigital electrode interface.
Fig. 3 is excited oscillation and signal acquisition module synoptic diagram
301 is operational amplifier among the figure; 302 is resonant transducer; 303 is single-chip microcomputer; 304 is the control criterion second signal circuit; 305 is wave point; 306 is the Flash flash memory; 307 is LCD (LCD).
Embodiment
Below in conjunction with accompanying drawing further description is done in practical implementation of the present invention.
The resonance electrode array is made up of 8 interdigitation comb electrodes 201 and electrode interface 202.The excited oscillation module is made up of high speed integrated operational amplifier 301 and resistance (R1, R2, R3, R4), electric capacity (C1, C2) etc., and wherein R1, R4 link to each other with power supply VCC respectively, R2; C1; R3 is continuous with 1,2,3 pin of high speed integrated operational amplifier respectively; Resonant transducer 302 is connected on capacitor C 2 and forms vibration in the circuit, and output has the frequency signal of Transistor-Transistor Logic level then.This circuit design makes resonance sensor systems under full liquid-phase condition, still can vibrate.When the liquid physicochemical property changed, the natural frequency of liquid will change thereupon, the frequency of adjustment excited oscillation signal; Make it produce resonance with the liquid natural frequency; 0 mouthful of the interruption of resonant frequency signal entering single-chip microcomputer 303, and the gate time of standard second signal is through 1 mouthful of entering of interruption of single-chip microcomputer 303, through the gate time of control criterion second signal circuit 304; The frequency of 303 pairs of hunting of frequency module outputs of single-chip microcomputer detects; Realize the detection to other signal through obtaining the A/D converter result simultaneously, testing result liquor charging crystal display 307 shows in real time, is stored in simultaneously in the Flash flash memory 306; Also can give wave point 305, be sent to computing machine during then through wireless cause for gossip and do that further processing, analysis, demonstration, storage and long-range shared etc. through the microcontroller communication oral instructions.
Claims (3)
1. liquid resonance sensor method and system is characterized in that: the interdigital microelectrode array resonant transducer of a gold-plated film is set, designs corresponding excited oscillation circuit; Based on the liquid resonance principle, utilize the frequency collection circuit to obtain resonant frequency characteristic, directly send into SCM system; After the single-chip microcomputer processing; Be sent to computing machine through wireless communication interface, utilize the relation between change of resonance frequency and liquid inherent characteristic, obtain characterisitic parameters such as liquid viscoelasticity, density, composition and concentration thereof.
2. liquid resonance sensor method and system according to claim 1; It is characterized in that: character such as liquid viscoelasticity, density, specific inductive capacity can be characterized by the liquid natural frequency, and under the alternating signal effect that the excited oscillation circuit applies, liquid produces resonance; When liquid property changes; Respective change can take place in its resonance frequency, measures the oscillatory response of resonant transducer, utilizes zero cross detection circuit that this response signal is shaped to square wave output; Utilize frequency measurement circuit to carry out frequency measurement then, also can obtain the amplitude characteristic of resonance signal through the signal conditioning circuit of system.
3. liquid resonance sensor method and system according to claim 1; It is characterized in that: modification has the functional molecular of specificity combination to biomolecule or chemical constitution on golden film; But the measurement function molecule combines and applies the frequency and the dynamic dissipated wave of output response signal behind the excited oscillation signal with composition to be measured, realizes the specific detection to biochemical molecular.
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Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109142657A (en) * | 2017-06-28 | 2019-01-04 | 中国科学院宁波工业技术研究院慈溪生物医学工程研究所 | A kind of detection analysis instrument |
| CN109164253A (en) * | 2018-10-26 | 2019-01-08 | 浙江师范大学 | A kind of tuning fork resonant mode blood platelet shrinks force measuring device and method |
| CN109844493A (en) * | 2016-06-13 | 2019-06-04 | Inl-国际伊比利亚纳米技术实验室 | Method for verifying resonator |
| CN110609081A (en) * | 2019-10-22 | 2019-12-24 | 广州蓝勃医学诊断技术有限公司 | A vibration detection sensor for liquid detection based on vibration principle and its application |
| CN110609082A (en) * | 2019-10-22 | 2019-12-24 | 广州蓝勃医学诊断技术有限公司 | Liquid detection device based on vibration principle and detection method and application thereof |
| CN112924491A (en) * | 2021-01-27 | 2021-06-08 | 江苏科技大学 | Blood coagulation detection device and detection method thereof |
| CN113089187A (en) * | 2021-02-21 | 2021-07-09 | 金大付 | Medical long fiber non-woven fabric preparation device and method |
| US11333661B2 (en) | 2017-06-28 | 2022-05-17 | Cixi Institute Of Biomedical Engineering Ningbo Institute Of Industrial Technology, Chinese Academy Of Sciences | Detection analyzer |
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Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109844493A (en) * | 2016-06-13 | 2019-06-04 | Inl-国际伊比利亚纳米技术实验室 | Method for verifying resonator |
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| CN109142657A (en) * | 2017-06-28 | 2019-01-04 | 中国科学院宁波工业技术研究院慈溪生物医学工程研究所 | A kind of detection analysis instrument |
| US11333661B2 (en) | 2017-06-28 | 2022-05-17 | Cixi Institute Of Biomedical Engineering Ningbo Institute Of Industrial Technology, Chinese Academy Of Sciences | Detection analyzer |
| CN109164253A (en) * | 2018-10-26 | 2019-01-08 | 浙江师范大学 | A kind of tuning fork resonant mode blood platelet shrinks force measuring device and method |
| CN110609081A (en) * | 2019-10-22 | 2019-12-24 | 广州蓝勃医学诊断技术有限公司 | A vibration detection sensor for liquid detection based on vibration principle and its application |
| CN110609082A (en) * | 2019-10-22 | 2019-12-24 | 广州蓝勃医学诊断技术有限公司 | Liquid detection device based on vibration principle and detection method and application thereof |
| CN110609081B (en) * | 2019-10-22 | 2025-07-11 | 广州蓝勃医学诊断技术有限公司 | A vibration detection sensor for liquid detection based on vibration principle and its application |
| CN112924491A (en) * | 2021-01-27 | 2021-06-08 | 江苏科技大学 | Blood coagulation detection device and detection method thereof |
| CN112924491B (en) * | 2021-01-27 | 2022-08-19 | 江苏科技大学 | Hemagglutination detection device and detection method thereof |
| CN113089187A (en) * | 2021-02-21 | 2021-07-09 | 金大付 | Medical long fiber non-woven fabric preparation device and method |
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