CN102805775A

CN102805775A - Medicine for treating rheumatic arthritis and preparation method thereof

Info

Publication number: CN102805775A
Application number: CN2012103047316A
Authority: CN
Inventors: 兰恒志
Original assignee: Individual
Current assignee: Individual
Priority date: 2012-08-25
Filing date: 2012-08-25
Publication date: 2012-12-05
Anticipated expiration: 2032-08-25
Also published as: CN102805775B

Abstract

The invention discloses a medicine for treating rheumatic arthritis and a preparation method thereof. The medicine is mainly prepared from broad leaf vetch, ground beetle, medicinal cyathula root, phellodendron, suberect spatholobus stem, Japanese honeysuckle stem, dried rehmannia and the like in a certain weight ratio. The medicine for treating rheumatic arthritis has effects of reinforcing qi and nourishing blood, dispelling wind and eliminating dampness, expelling wind, dredging collaterals and dissipating blood stasis, and is quick in response, short in treatment course and high in cure rate, and rheumatic arthritis does not relapse.

Description

A kind of medicine of treating rheumatic arthritis and preparation method thereof

Technical field

The present invention relates to a kind of medicine of treating rheumatic arthritis and preparation method thereof, belong to the field of Chinese medicines.

Background technology

Rheumatic arthritis is a kind of common acute or chronic ICT.Can show effect repeatedly and involve heart.Clinical miserable with joint and muscle the. fugitive, heavily work, pain is characteristic.Belong to allergic disease.Be one of main performance of rheumatic fever, how with febris acuta and arthralgia onset.Typical case's performance of rheumatic arthritis is slight or the moderate heating; Mostly migratory polyarthritis, the joint of getting involved are big joint such as knee joint, ankle, shoulder, elbow wrist, commonly are transferred to another joint by a joint; the pathological changes part presents redness, scorching hot, severe pain part patient also has several joints to fall ill simultaneously; atypical patient only has arthralgia and do not have other inflammation performances, and acute inflammation generally disappears in 2-4 week and do not stay sequela, but the Chang Fanfu outbreak.At present, because Western medicine can't effectively be treated rheumatic arthritis, and has certain side effect, therefore, there is very big demand in people to the Chinese medicine of effective treatment rheumatic arthritis.

Summary of the invention

The inventor has found the medicine of effective treatment rheumatic arthritis finally, thereby has accomplished the present invention according to the research of theory of Chinese medical science and clinical repeatedly test and checking.

The object of the invention just provides a kind of composition of medicine that can treat rheumatic arthritis.

Another object of the present invention has just provided the method for preparing of this composition of medicine.

Medicine of the present invention selects Herba Viciae Amoenae, Eupolyphaga Seu Steleophaga, Radix Achyranthis Bidentatae, RADIX ACONITILATERALIS PREPARATA, Radix Stephaniae Tetrandrae, Radix Glycyrrhizae Preparata, Cortex Phellodendri, Caulis Spatholobi, Lumbricus, Radix Gentianae Macrophyllae, Caulis Lonicerae, Semen Persicae, Semen Armeniacae Amarum, Radix Rehmanniae, the Rhizoma Atractylodis Macrocephalae, Ramulus Cinnamomi medicine to make up; Make each efficacy of drugs produce synergism these drug regimens, thereby can effectively treat the recurrence of rheumatic arthritis.Wherein selecting Herba Viciae Amoenae for use, call bean seedling, mountain Semen sojae atricolor, Herba speranskiae tuberculatae, is that temperature has wind-damp dispelling because of its nature and flavor sweetness and bitterness, invigorate blood circulation, and Shujin, the analgesic function, the dispelling the wind and dampness pathogens pain, sprain and contusion are hindered, innominate toxic swelling, eczema scrotum.It is salty because of its nature and flavor, cold, slightly poisonous selecting Eupolyphaga Seu Steleophaga for use.Return Liver Channel.Removing blood stasis with potent drugs blood, reuniting the fractured tendons and bones.Be used for the muscles and bones folding and hinder blood stasis amenorrhea ， mass in the abdomen mass in the abdomen.Select for use Radix Achyranthis Bidentatae to be because its nature and flavor sweetness and bitterness acid is flat, go into liver, kidney channel, give birth to and use dissipating blood stasis blood, subduing inflammation is controlled gonorrhea, hematuria; Amenorrhea ， mass in the abdomen, difficult labour, retention of placenta, postnatal blood stasis stomachache, sore throat, carbuncle; Traumatic injury is ripely used invigorating the liver and kidney, and bone and muscle strengthening is controlled waist kneecap pain, four fertile contractures, flaccidity syndrome and arthralgia syndrome.Aconite is chosen because of their sexual Weixin Gan, thermal, toxic, into the heart, spleen, kidney, there back to the sun make up the fire, cold and dampness features, yin Sheng Geyang, sweating death Yang, Tuli Jueni, confidants Leng Tong, spleen vent cold dysentery, beriberi edema, pediatric slow shock, wind musculoskeletal, Wei lame Spasm, overcast gangrene cold sores sink drain and all inveterate cold of the disease.Select for use Radix Stephaniae Tetrandrae to be because its nature and flavor are bitter, cold, go into wing thorax, spleen, kidney channel, capable water is arranged, rush down the function of damp-heat in lower-JIAO, the swollen tympanites of harnessing the river, hygropyretic beriberi, brothers' spasm and pain, the tinea scabies is swollen.Select for use Radix Glycyrrhizae to be because its nature and flavor are sweet flat, go into spleen, stomach, lung meridian, have and middle emergency, lung moistening, detoxifcation; The function of coordinating the actions of various ingredients in a prescription is processed with controlling weakness of the spleen and stomach, lack of appetite, stomachache loose stool; The overstrain heating, consumptive lung disease cough, cardiopalmus, frightened carbuncle; Give birth to controlling laryngopharynx swelling and pain, peptic ulcer, ulcer sores is separated poison of drug and alimentary toxicosis.Select for use Cortex Phellodendri to be because its nature and flavor are bitter, cold, go into lung, stomach, kidney channel, nourishing YIN to lower pathogenic fire is arranged, moisturize the function of laxation, control dysphoria with smothery sensation and quench one's thirst, hectic fever due to YIN-deficiency consumptive fever, cough due to lung-heat, constipation due to dry stool, dysuria.Selecting Caulis Spatholobi for use is because its property bitter but sweet flavor, and temperature is gone into the heart, spleen two warps, have invigorate blood circulation, the function of Shujin, control soreness of waist and knee joint, paralysis and numbness, menoxenia.Select for use Lumbricus to be because its nature and flavor are salty, cold, go into liver, spleen, lung meridian, heat clearing away is arranged, suppressing the hyperactive liver, Zhichuan, the function of collateral dredging; It is manic to control hyperpyrexia, convulsion with spasms, and headache due to pathogenic wind-heat, conjunctival congestion, apoplexy and hemiplegia is panted, sore throat; Arthralgia, bleeding from the gum, urinary obstruction, scrofula, mumps, skin infection.Select for use Radix Gentianae Macrophyllae to be because its nature and flavor toil is flat, go into liver, stomach, gallbladder meridian, expelling wind and removing dampness and blood Shujin are arranged, the function of clearing away heat and promoting diuresis, the dispelling the wind and dampness pathogens arthralgia pain, the muscles and bones contracture, jaundice is had blood in stool, osteopyrexia and fever, children's's infantile malnutrition with fever, dysuria.Select for use Caulis Lonicerae to be because its nature and flavor are sweet, cold, go into the heart, lung meridian, heat clearing away is arranged, detoxifcation, the function of collateral dredging is controlled the epidemic febrile disease heating, toxic-heat and blood stasis, infectious hepatitis, carbuncle sore tumefacting virus, bones and muscles pain.Select for use Semen Persicae to be because its property bitter but sweet flavor is flat, go into the heart, liver, large intestine channel, blood stasis removing and clots absorbing is arranged, moisturize the function of sliding warp, control amenorrhea, mass in the abdomen, calentura blood-retention, arthralgia due to stagnation of blood, malaria, traumatic injury, swelling and pain due to blood stasis, the dry constipation of blood.Select for use Semen Armeniacae Amarum to be because its nature and flavor are bitter, temperature, poisonous, go into lung, large intestine channel, expelling phlegm for arresting cough is arranged, to relieving asthma, the function of intestine moistening is controlled the exogenous cough, dyspnea with fullness of the chest, sore throat, dryness of the intestine constipation.Selecting Radix Rehmanniae for use is that the heart, liver, kidney channel are gone in cold, and YIN nourishing is arranged because of its nature and flavor sweetness and bitterness, and the function that nourishes blood is controlled fever due to yin deficiency, quenches one's thirst, spit blood, and epistaxis, metrorrhagia, menoxenia, frequent fetal movement, the moon is hindered constipation.Selecting the Rhizoma Atractylodis Macrocephalae for use is because its property bitter but sweet flavor, and temperature is gone into spleen, stomach warp, and spleen reinforcing is arranged, stomach reinforcing, dampness and in function, control deficient QI of the spleen and stomach, anorexia, the asthenia weak breath, deficiency-distension is had loose bowels, phlegm retention, edema, jaundice, arthralgia chiefly caused by damp pathogen, dysuria, dizziness, spontaneous perspiration, nausea is uneasy.Selecting Ramulus Cinnamomi for use is that temperature is gone into bladder, the heart, lung meridian, and the diaphoresis expelling pathogenic factors from muscles is arranged because of its property acrid-sweet flavor, and the function of warming the meridian and promoting blood circulation is controlled exterior syndrome due to wind-cold, shoulder back of the body podomere ache, thoracic obstruction phlegm retention, amenorrhea and mass in the abdomen.

The specific embodiment

Amount of drug of the present invention also is that the inventor draws through groping in a large number to sum up, and the consumption of each component all has better curative effect in following weight range

Herba Viciae Amoenae 15-25 gram Eupolyphaga Seu Steleophaga 10-20 gram Radix Achyranthis Bidentatae 3-7 gram

RADIX ACONITILATERALIS PREPARATA 5-15 gram Radix Stephaniae Tetrandrae 10-20 gram Radix Glycyrrhizae Preparata 5-15 gram

Cortex Phellodendri 5-15 gram Caulis Spatholobi 5-15 gram Lumbricus 15-25 gram

Radix Gentianae Macrophyllae 25-35 gram Caulis Lonicerae 25-35 gram Semen Persicae 5-5 gram

Semen Armeniacae Amarum 10-20 gram Radix Rehmanniae 10-20 gram Rhizoma Atractylodis Macrocephalae 3-7 gram

Ramulus Cinnamomi 5-15 gram

Wherein, be preferably

Herba Viciae Amoenae 20 gram Eupolyphaga Seu Steleophagas 15 gram Radix Achyranthis Bidentataes 5 grams

RADIX ACONITILATERALIS PREPARATA 10 gram Radix Stephaniae Tetrandrae 15 gram Radix Glycyrrhizae Preparatas 10 grams

Cortex Phellodendri 10 gram Caulis Spatholobis 10 gram Lumbricuss 20 grams

Radix Gentianae Macrophyllae 30 gram Caulis Loniceraes 30 gram Semen Persicaes 10 grams

The Semen Armeniacae Amarum 15 gram Radix Rehmanniaes 15 gram Rhizoma Atractylodis Macrocephalaes 5 grams

Ramulus Cinnamomi 10 grams

The method for preparing of medicine of the present invention is following

One, gets the raw materials ready

1, Herba Viciae Amoenae: choose decontamination, dry;

2, Eupolyphaga Seu Steleophaga: get crude drug, cleaning, drying;

3, Radix Achyranthis Bidentatae: choose decontamination, clean, moisten softly, go reed, cutting is dried;

4, RADIX ACONITILATERALIS PREPARATA: salty Radix Aconiti Lateralis Preparata is cleaned, floated 2～3 days, change water every day 2～3 times, go most saline taste, take out, put in the pot, add water and bean curd with boiling, do not have picotement to chewing, take out, remove bean curd, profit in airing to outer the doing is cut wafer thin, dries sieve dedust bits;

5, Radix Stephaniae Tetrandrae: former medicinal washing is clean, pulls out to run through, and section is dried;

6, Radix Glycyrrhizae Preparata: the extracting liquorice sheet add cooked Mel and boiled water a little, mix thoroughly, vexed slightly, put in the pot with slow fire and fry to becoming buff, tack-freely be degree, taking-up cools, 100 jin in every Radix Glycyrrhizae is with the close 25-30 jin of refining;

7, Cortex Phellodendri: remove impurity, the spray clear water runs through shredding, drying;

8, Caulis Spatholobi: water runs through, section, or steam and take advantage of fervent sheet after soft, dry;

9, Lumbricus: choose decontamination, water rinses, and in time pulls out, dries cutting;

10, Radix Gentianae Macrophyllae: choose decontamination, remove removing LU, soak slightly, run through section, dry;

11, Caulis Lonicerae: choose decontamination, be soaked in water, run through, section is dried;

12, Semen Persicae: remove duricrust impurity, put and boil in the boiling water pot to the little wrinkle of crust, pull out, immerse in the cold water, rub with the hands and remove kind of a skin, dry, it is clean to winnow with a dustpan;

13, Semen Armeniacae Amarum: choose clean impurity, put the boiling water part omitted and boil, the Pi Wei that waits purses up and pulls out, soaks in the cold water, sloughs kind of a skin, dries, and it is clean to winnow with a dustpan;

14, Radix Rehmanniae: water steeps slightly, cleans sediment contamination, pulls stewing profit out, and section is dried or dried;

15, the Rhizoma Atractylodis Macrocephalae: choose clean impurity, be soaked in water, pull out behind the bubble, run through, section is dried;

16, Ramulus Cinnamomi: water soaks slightly, pulls out, and moistening is to passing through, and section is dried, and sieves anti-dandruff.

Two, preparation

1, with Herba Viciae Amoenae, Eupolyphaga Seu Steleophaga, Radix Achyranthis Bidentatae, RADIX ACONITILATERALIS PREPARATA, Radix Stephaniae Tetrandrae, Radix Glycyrrhizae Preparata, Cortex Phellodendri, Caulis Spatholobi, Lumbricus, Radix Gentianae Macrophyllae, Caulis Lonicerae, Semen Persicae, Semen Armeniacae Amarum, Radix Rehmanniae, the Rhizoma Atractylodis Macrocephalae, the Ramulus Cinnamomi decocte with water of said weight; Add for the first time 6 times of amounts of water; Soaked 60 minutes; Decoct boiling 30 minutes with high heat, reuse slow fire boiling 20 minutes, time decoction liquor of promptly winning.

2, will filter the back medicinal residues for the first time and add 3 times of amounts of water, and decoct boiling, the reuse slow fire boiling promptly got decoction liquor for the second time in 15 minutes.

3, twice decoction liquor mixed, reuse slow fire boiling 20 minutes is divided into 2 doses with medicinal liquid and takes.

Medicine of the present invention has the effect of benefiting QI and nourishing blood, expelling wind and removing dampness, expel wind to dredge collateral silt, and treatment rheumatic arthritis instant effect, short treating period do not recur.

Below come further to set forth the beneficial effect of medicine of the present invention, these tests to comprise that the animal toxicity test of medicine of the present invention and clinical observation test through Test Example.

The animal toxicity test report of [Test Example 1] medicine of the present invention

Get 30 of rabbit, the male and female dual-purpose, body weight 2.0-2.5kg divides two groups, and 15 every group, wherein one group is the overdose test group, and another group is the normal amount test group.The super quantity group is 20ml/kg, and normal amount is 10ml/kg, and administering mode is the administration by gavage administration, serve on 7 days every day twice, observes the administration reaction every day, and the result shows that two groups of rabbit are movable, diet is normal, and medicine does not have bad toxic and side effects.

The clinical observation material of [Test Example 2] medicine of the present invention

1, physical data

Accept out-patient's 260 examples for medical treatment, male patient's 160 examples wherein, female patient 100 examples.

2, diagnostic criteria

Rheumatic arthritis: the patient joint is red, swollen, hot, pain is obvious, and stiff, site of pathological change usually is the big joints of lower limb such as knee joint, hip, ankle, secondly is shoulder, elbow, carpal joint, and brothers' little joint is rare, and the pain migration is indefinite, outbreak repeatedly, protracted course of disease.

3, Therapeutic Method

Select above-mentioned medicament for use, take, take 1 dose at every turn to the patient, every day early, respectively obey 1 time evening, 30 days is a course of treatment, takes 2-3 the course of treatment continuously.

4, efficacy assessment standard

Produce effects: treatment back clinical symptom disappearance, it is normal that recover in the joint, observes and do not have the recidivist half a year;

Take a turn for the better: clinical symptoms is obviously improved, and progressively recover in the joint;

Invalid: clinical partial symptoms disappears or does not have change, does not reach improvement standard person.

5, therapeutic outcome

Figure 2012103047316100002DEST_PATH_IMAGE001

In above-mentioned treatment, with Drug therapy rheumatic arthritis patient 260 examples of the present invention, produce effects 134 examples as a result, obvious effective rate is 87.31%%, 30 examples that take a turn for the better, improvement rate is 11.54%, invalid 3 examples, total effective rate is 98.85%.

Claims

1. medicine of treating rheumatic arthritis, it is characterized in that: it is to be processed by the crude drug in the following weight scope:

Cortex Phellodendri 5-15 gram Caulis Spatholobi 5-15 gram Lumbricus 15-25 gram

Ramulus Cinnamomi 5-15 gram.

2. medicine according to claim 1, wherein the consumption of each crude drug is:

Cortex Phellodendri 10 gram Caulis Spatholobis 10 gram Lumbricuss 20 grams

Ramulus Cinnamomi 10 grams.

3. according to the method for preparing of claim 1 or 2 said medicines, it is characterized in that: it comprises the following steps:

(1) gets the raw materials ready

(1) Herba Viciae Amoenae: choose decontamination, dry;

(2) Eupolyphaga Seu Steleophaga: get crude drug, cleaning, drying;

(3) Radix Achyranthis Bidentatae: choose decontamination, clean, moisten softly, go reed, cutting is dried;

(4) RADIX ACONITILATERALIS PREPARATA: salty Radix Aconiti Lateralis Preparata is cleaned, floated 2～3 days, change water every day 2～3 times, go most saline taste, take out, put in the pot, add water and bean curd with boiling, do not have picotement to chewing, take out, remove bean curd, profit in airing to outer the doing is cut wafer thin, dries sieve dedust bits;

(5) Radix Stephaniae Tetrandrae: former medicinal washing is clean, pulls out to run through, and section is dried;

(6) Radix Glycyrrhizae Preparata: the extracting liquorice sheet add cooked Mel and boiled water a little, mix thoroughly, vexed slightly, put in the pot with slow fire and fry to becoming buff, tack-freely be degree, taking-up cools, 100 jin in every Radix Glycyrrhizae is with the close 25-30 jin of refining;

(7) Cortex Phellodendri: remove impurity, the spray clear water runs through shredding, drying;

(8) Caulis Spatholobi: water runs through, section, or steam and take advantage of fervent sheet after soft, dry;

(9) Lumbricus: choose decontamination, water rinses, and in time pulls out, dries cutting;

(10) Radix Gentianae Macrophyllae: choose decontamination, remove removing LU, soak slightly, run through section, dry;

(11) Caulis Lonicerae: choose decontamination, be soaked in water, run through, section is dried;

(12) Semen Persicae: remove duricrust impurity, put and boil in the boiling water pot to the little wrinkle of crust, pull out, immerse in the cold water, rub with the hands and remove kind of a skin, dry, it is clean to winnow with a dustpan;

(13) Semen Armeniacae Amarum: choose clean impurity, put the boiling water part omitted and boil, the Pi Wei that waits purses up and pulls out, soaks in the cold water, sloughs kind of a skin, dries, and it is clean to winnow with a dustpan;

(14) Radix Rehmanniae: water steeps slightly, cleans sediment contamination, pulls stewing profit out, and section is dried or dried;

(15) Rhizoma Atractylodis Macrocephalae: choose clean impurity, be soaked in water, pull out behind the bubble, run through, section is dried;

(16) Ramulus Cinnamomi: water soaks slightly, pulls out, and moistening is to passing through, and section is dried, and sieves anti-dandruff;

(2) preparation

(1) with Herba Viciae Amoenae, Eupolyphaga Seu Steleophaga, Radix Achyranthis Bidentatae, RADIX ACONITILATERALIS PREPARATA, Radix Stephaniae Tetrandrae, Radix Glycyrrhizae Preparata, Cortex Phellodendri, Caulis Spatholobi, Lumbricus, Radix Gentianae Macrophyllae, Caulis Lonicerae, Semen Persicae, Semen Armeniacae Amarum, Radix Rehmanniae, the Rhizoma Atractylodis Macrocephalae, the Ramulus Cinnamomi decocte with water of said weight; Add for the first time 6 times of amounts of water; Soaked 60 minutes; Decoct boiling 30 minutes with high heat, reuse slow fire boiling 20 minutes, time decoction liquor of promptly winning;

(2) will filter the back medicinal residues for the first time and add 3 times of amounts of water, and decoct boiling, the reuse slow fire boiling promptly got decoction liquor for the second time in 15 minutes;

(3) twice decoction liquor mixed, reuse slow fire boiling 20 minutes is divided into 2 doses with medicinal liquid and takes.