CN102772801A - Wound spray for treating bruises and preparation method of wound spray - Google Patents
Wound spray for treating bruises and preparation method of wound spray Download PDFInfo
- Publication number
- CN102772801A CN102772801A CN2012102838141A CN201210283814A CN102772801A CN 102772801 A CN102772801 A CN 102772801A CN 2012102838141 A CN2012102838141 A CN 2012102838141A CN 201210283814 A CN201210283814 A CN 201210283814A CN 102772801 A CN102772801 A CN 102772801A
- Authority
- CN
- China
- Prior art keywords
- wound
- mix homogeneously
- stock solution
- spray
- film forming
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
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- 239000010409 thin film Substances 0.000 description 1
- 230000001052 transient effect Effects 0.000 description 1
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 description 1
- 230000002087 whitening effect Effects 0.000 description 1
- 239000008096 xylene Substances 0.000 description 1
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Abstract
The invention provides a wound spray for treating bruises. The wound spray is composed of effect ingredients and a blank film formation stock solution, the effect ingredient are selected from one or more of external use disinfectants, external use antibiotics, local anesthetic and skin astringing ingredients, the blank film formation stock solution comprises polyvinyl butyral, a film formation auxiliary, a plastification viscosity-regulation agent, a surface active agent, a volatilization-assisted antisticking agent, a porogen, an aromatic and a solvent. The wound spray has the advantages that the film formation auxiliary is added so that formed films are more elastic; by means of the plastification viscosity-regulation agent, the regulated viscosity of the formed films is more suitable; by means of the volatilization-assisted antisticking agent, the volatilization of the stock solution is accelerated, and a spray valve is prevented from being blocked; and by means of combined actions of the ingredients, the wound spray is good in bactericidal effects and bioadhesive performances and capable of accelerating wound healing, ventilating wounds, preventing bacteria, inhibiting the bacteria and wetting the wounds.
Description
Technical field
The present invention relates to a kind of can be used to abrade treatment and at the rapid film forming wound spray of abrasion, belong to field of medical technology.
Background technology
Skin abrasion is a kind of very common wound, be violence with skin be the tangent line position contact due to damage, particularly palm, ancon, knee, shank, buccal etc. are located the easiest causing injury, wound surface differs in size.The visible epidermis in scratch back is damaged, and wound surface presents pale asphyxia, and has many little petechias and tissue fluid to ooze out, and the wound that has can reach subcutaneous deeply, causes the damage of skin holostrome.Wound surface that forms after the skin damage such as malpractice then are prone to cause infection suppurates, prolongedly do not heal, and form cicatrix, perhaps local pigmentation.Therefore how to handle wound well and promote wound and wound surface heals as early as possible; Reduce to greatest extent or avoid the expansion of wound surface and infection to increase the weight of, and avoid the cicatrization behind the wound healing, be to be engaged in that the treatment of wounds medical personnel pays close attention to and the problem of research for many years always; The mode of wrapping commonly used is treated at present; Its advantage is that wound surface can normal healing under glitch-free environment, but occlusive dressing is used for juxta-articular wound more, because the joint part mobility is big; The chance that is rubbed is many, makes wound be difficult to healing.
Adhesive bandage, " styptic plaster " is otherwise known as.Generally can only be used for neatly clean, hemorrhage few and don't the minor cut or wound that needs are sewed up of comparatively shallow table, wound, play temporary transient hemostasis, protect the effect of wound surface.In the life, we often can use adhesive bandage, particularly minor cut or wound, have gone out a blood, and often all think and paste an adhesive bandage with regard to everything is just fine, be not right in fact like this.The water absorption and the aeration of adhesive bandage itself are relatively poor, are unfavorable for the drain of wound secretions, and the anti-growth and breeding that is beneficial to antibacterial makes wound and skin whitening, deliquescing on every side, causes supervention to infect.And adhesive bandage when wound is torn since above the effect of pressure sensitive adhesive newborn epidermal laceration is held, cause the patient to produce pain.In order to overcome the shortcoming of traditional adhesive bandage, occurred the liquid adhesive bandage now, and selected for use the method for spraying to be injected in the wound rapidly; Form film body in wound surface fast; Play the protection wound and avoid the influence of extraneous factor, and film body is frivolous, non-stimulated; Well do not come off the effect of absorptive tissue penetrating fluid with the adhesiveness of skin.
Chinese patent CN201010200561.8 improves to existing film technique, has announced a kind and has prepared improving one's methods of liquid adhesive bandage.This patent exists following weak point: spray former fluid viscosity and surface tension are higher, are not suitable for the press type sprayer unit; And after liquid adhesive bandage volatile solvent fully volatilized, this liquid adhesive bandage film body was relatively drier; The film body poor flexibility; Easy blocking shower nozzle behind the use sprayer unit; Film body does not have ventilative pore effect.These unfavorable factors are very disadvantageous to the healing of wound, because wound is the several times under dry and/or the airtight situation at healing rate under the gas-pervious situation of moistening.
Summary of the invention
The objective of the invention is to overcome the weak point of prior art, a kind of abrasive wound spray and preparation method thereof that is used to treat is provided.
Of the present inventionly be used to treat abrasive wound spray; Form by functional component and blank film forming stock solution; Said functional component is selected from one or more in disinfectant for external use, topical antibiotic, local anesthetic and the skin contraction composition, and said blank film forming stock solution comprises polyvinyl butyral, coalescents, plasticising adjusting adhesive, surfactant, helps volatilization antiplastering aid, porogen, aromatic and solvent;
Each composition shared mass percent in the wound spray is following:
Said disinfectant for external use is selected from polymer, acrylic disulfide or the acrylic trithioether of benzalkonium chloride, benzalkonium bromide, iodine, iodine; Said topical antibiotic is selected from mupirocin, erythromycin or griseofulvin; Said local anesthetic is lignocaine, procaine, tetracaine, bupivacaine, ropivacaine or ibuprofen; Said skin contraction composition is selected from tannic acid, silver nitrate or zinc sulfate.
Said coalescents is an ethyl cellulose; Said plasticising adjusting adhesive is selected from ethyl oleate, triethyl citrate, diethyl phthalate, dimethyl phthalate, dibutyl phthalate or silicone oil and derivant thereof; Said surfactant is a sodium lauryl sulphate; Said help the volatilization antiplastering aid be isobutyltrimethylmethane.; Said porogen is polyvinylpyrrolidone-vinyl acetate co-polymer or polyvinylpyrrolidone; Said aromatic is rose essence, Flos Jasmini Sambac Oleum sesami, wintergreen oil, Oleum menthae or Eucalyptus oil; Said solvent is one or several in ethanol, ethyl acetate, acetone, the propylene glycol.
Of the present inventionly be used to treat abrasive wound spray preparing process, it is characterized in that, comprise the steps:
1) functional component pre-prepared: the functional component, aromatic, porogen, the surfactant that take by weighing recipe quantity mix
Close evenly, add proper amount of solvent, in the high speed homogenization dispersion machine, fully disperse the back subsequent use;
2) blank film forming stock solution preparation: take by weighing recipe quantity polyvinyl butyral, plasticising adjusting adhesive, coalescents,
Help volatilization antiplastering aid mix homogeneously, add the solvent of surplus, mix homogeneously dissolves it fully;
3) with the reserve liquid and the step 2 of step 1)) the abundant mix homogeneously of blank film forming stock solution, and pour into spraying
Promptly get in the device.
Among the present invention,
Polyvinyl butyral resin is not the general designation of the condensation product of polyvinyl alcohol and various aldehydes, is a kind of very ideal filmogen of pure dissolubility, has good elasticity, toughness, nonpoisonous and tasteless, and is contaminated, to outstanding character such as skin do not stimulate.
Ethyl cellulose is to be called for short EC, and is generally water insoluble, and is dissolved in different organic solvents; Heat stability is good, ash is extremely low during burning, the adhesion sense is seldom arranged or send out puckery; Can generate tough and tensile thin film, when low temperature, still can keep flexibility, these article are nontoxic; Extremely strong antibiont performance is arranged, and the metabolism inertia is used to help film forming material at these article.
Ethyl oleate (Ethyl Oleate) is used for the preparation of surfactant and other organic chemicals, also as spice, is mainly used in plasticization, the adjusting viscosity of these article.
Triethyl citrate, triethyl citrate, diethyl phthalate, dimethyl phthalate, dibutyl phthalate all are used as the plasticizer as adhesive and sealant, are mainly used in plasticization, the adjusting viscosity of these article.
Silicone oil and derivant thereof have many properties, and, high-low temperature resistant, antioxidation little like the sticking coefficient of temperature, flash-point is high, volatility is little, good insulating, surface tension are little, it is nontoxic etc. that metal is not had burn into.Because these characteristics, silicone oil has remarkable effect in many aspects to use, and is mainly used in plasticization, the adjusting viscosity of these article.
Sodium lauryl sulphate is a kind of white or faint yellow little sticking thing, is usually used in detergent and textile industry in the industry.Belong to anion surfactant.Soluble in water, compatibility is good again with anion, nonionic, has good emulsifying, foaming, infiltration, decontamination and dispersive property, can effectively reduce surface tension.
Isobutyltrimethylmethane. is a kind of colourless transparent liquid.Be dissolved in benzene,toluene,xylene, chloroform, ether, Carbon bisulfide, carbon tetrachloride, dimethyl formamide and fall the oils beyond the Oleum Ricini, be slightly soluble in dehydrated alcohol, water-soluble hardly, help volatilization and the auxiliary effect that reduces viscosity.
Vinyl pyrrolidone/vinyl acetate co-polymer also is a kind of very ideal filmogen of pure dissolubility, have well nonpoisonous and tasteless, to skin do not have to stimulate, not contaminated, with contact skin closely, outstanding character such as natural degradation easily.
Polyvinylpyrrolidone (polyvinyl pyrrolidone) is called for short PVP; A kind of very ideal filmogen of pure dissolubility is a kind of non-ionic macromolecule compound; Be most characteristic in the N vinylamide polymer, and be studied the most deeply, fine chemicals kind widely.Have colloid protective effect, film property, caking property, hygroscopicity, solubilising or cohesion, but it is most characteristic, thereby what receive that people pay attention to is its excellent solubility property and physiological compatibility.
Rose essence, jasmine Oleum sesami, Eucalyptus oil, wintergreen oil, Oleum menthae are mainly used in the fragrance of these article of adjusting.
Ethyl acetate, ethanol, acetone, propylene glycol all are good volatile solvents, and ethyl acetate has fruit aroma, are the aromatic of this spray.
Wound spray of the present invention has following technique effect:
1) through adding coalescents, makes its more high resilience of film body that becomes;
2) it is more suitable that the plasticising adjusting adhesive makes the viscosity adjustment of its film body that becomes;
3) help the volatilization antiplastering aid can quicken the volatilization of stock solution, prevent that spray valve from stopping up;
4) various composition combineds effect make that spray of the present invention can accelerating wound, have better bactericidal effect, more ventilative, fungi-proofing, antibacterial, bioadhesive is good, can the moistening wound.
Description of drawings
The injured situation map of scratch mark when Fig. 1 is the product of uncoated embodiment 1;
Fig. 2 is scratch mark incrustation situation map behind the product in using embodiment 1 after 1 day; As can beappreciated from fig. 2, healing rate is obviously accelerated, no bacterial infection;
Fig. 3 be after 5 days scratch mark in using embodiment 1 behind the product the recovery from illness situation map; As can beappreciated from fig. 3, skin is completely recovered;
Fig. 4 is the wound wound face figure of the product of uncoated embodiment 1;
Fig. 5 is the design sketch that has been coated with on the wound behind the product of embodiment 1; As can beappreciated from fig. 5, the coating compatibility even and skin is good, nonirritant;
After Fig. 6 was 1 day, the product film body of embodiment 1 was by the wound surface design sketch after opening; As can beappreciated from fig. 6 skin does not infect, and does not have red and swollen phenomenon.These article of further illustrating have good hydrophobicity, and biocompatibility is non-stimulated to wound, do not have irritated reaction, can well protect wound.
The specific embodiment
Listed embodiment is for all being weight percentage.Wherein PVB is that polyvinyl butyral, EC are that ethyl cellulose, VA64 are vinyl pyrrolidone-vinyl acetate co-polymer, and PVP is a polyvinylpyrrolidone.
Embodiment 1
The component and the percentage by weight of the wound spray of present embodiment are following:
Preparation technology is following:
⑴ functional component pre-prepared: take by weighing benzalkonium chloride, rose essence, VA64, the sodium lauryl sulphate mix homogeneously of recipe quantity, add adequate amount of ethanol, in the high speed homogenization dispersion machine, fully disperse the back subsequent use.
⑵ blank film forming stock solution preparation: take by weighing PVB, isobutyltrimethylmethane., ethyl cellulose, the ethyl oleate mix homogeneously of recipe quantity, add the solvent of surplus, mix homogeneously dissolves it fully.
⑶ the abundant mix homogeneously of blank film forming stock solution of the reserve liquid of step ⑴ and step ⑵, and pour into and promptly get the liquid adhesive bandage that contains 0.2% benzalkonium chloride in the sprayer unit.
Embodiment 2
The component and the percentage by weight of the wound spray of present embodiment are following:
Preparation technology is following:
⑴ functional component pre-prepared: take by weighing benzalkonium bromide, Flos Jasmini Sambac Oleum sesami, VA64, the sodium lauryl sulphate mix homogeneously of recipe quantity, add an amount of ethyl acetate, in the high speed homogenization dispersion machine, fully disperse the back subsequent use.
⑵ blank film forming stock solution preparation: take by weighing PVB, isobutyltrimethylmethane., ethyl cellulose, the ethyl oleate mix homogeneously of recipe quantity, add the solvent of surplus, mix homogeneously dissolves it fully.
⑶ the abundant mix homogeneously of blank film forming stock solution of the reserve liquid of step ⑴ and step ⑵, and pour into and promptly get the liquid adhesive bandage that contains 0.2% benzalkonium bromide in the sprayer unit.
Embodiment 3
The component and the percentage by weight of the wound spray of present embodiment are following:
Preparation technology is following:
⑴ functional component pre-prepared: take by weighing lecithin iodine, Eucalyptus oil, VA64, the sodium lauryl sulphate mix homogeneously of recipe quantity, add an amount of acetone, in the high speed homogenization dispersion machine, fully disperse the back subsequent use.
⑵ blank film forming stock solution preparation: take by weighing PVB, isobutyltrimethylmethane., ethyl cellulose, the ethyl oleate mix homogeneously of recipe quantity, add the solvent of surplus, mix homogeneously dissolves it fully.
⑶ the abundant mix homogeneously of blank film forming stock solution of the reserve liquid of step ⑴ and step ⑵, and pour into and promptly get the liquid adhesive bandage that contains 0.2% lecithin iodine in the sprayer unit.
Embodiment 4
The component and the percentage by weight of the wound spray of present embodiment are following:
Preparation technology is following:
⑴ functional component pre-prepared: take by weighing acrylic acid disulfide, Oleum menthae, PVP, the sodium lauryl sulphate mix homogeneously of recipe quantity, add an amount of propylene glycol, in the high speed homogenization dispersion machine, fully disperse the back subsequent use.
⑵ blank film forming stock solution preparation: take by weighing PVB, isobutyltrimethylmethane., ethyl cellulose, the ethyl oleate mix homogeneously of recipe quantity, add the solvent of surplus, mix homogeneously dissolves it fully.
⑶ the abundant mix homogeneously of blank film forming stock solution of the reserve liquid of step ⑴ and step ⑵, and pour into and promptly get the liquid adhesive bandage that contains 0.2% acrylic acid disulfide in the sprayer unit.
Embodiment 5
The component and the percentage by weight of the wound spray of present embodiment are following:
Preparation technology is following:
⑴ functional component pre-prepared: take by weighing acrylic acid trithioether, wintergreen oil, pvp, the sodium lauryl sulphate mix homogeneously of recipe quantity, add adequate amount of ethanol, in the high speed homogenization dispersion machine, fully disperse the back subsequent use.
⑵ blank film forming stock solution preparation: take by weighing PVB, isobutyltrimethylmethane., ethyl cellulose, the ethyl oleate mix homogeneously of recipe quantity, add the solvent of surplus, mix homogeneously dissolves it fully.
⑶ the abundant mix homogeneously of blank film forming stock solution of the reserve liquid of step ⑴ and step ⑵, and pour into and promptly get the liquid adhesive bandage that contains 0.2% acrylic acid trithioether in the sprayer unit.
Embodiment 6
The component and the percentage by weight of the wound spray of present embodiment are following:
Preparation technology is following:
⑴ functional component pre-prepared: take by weighing mupirocin, Flos Jasmini Sambac Oleum sesami, pvp, the sodium lauryl sulphate mix homogeneously of recipe quantity, add adequate amount of ethanol, in the high speed homogenization dispersion machine, fully disperse the back subsequent use.
⑵ blank film forming stock solution preparation: take by weighing PVB, isobutyltrimethylmethane., ethyl cellulose, the ethyl oleate mix homogeneously of recipe quantity, add the solvent of surplus, mix homogeneously dissolves it fully.
⑶ the abundant mix homogeneously of blank film forming stock solution of the reserve liquid of step ⑴ and step ⑵, and pour into and promptly get the liquid adhesive bandage that contains 2% mupirocin in the sprayer unit.
Embodiment 7
The component and the percentage by weight of the wound spray of present embodiment are following:
Preparation technology is following:
⑴ functional component pre-prepared: take by weighing erythromycin, Herba Menthae Oleum sesami, VA64, the sodium lauryl sulphate mix homogeneously of recipe quantity, add adequate amount of ethanol, in the high speed homogenization dispersion machine, fully disperse the back subsequent use.
⑵ blank film forming stock solution preparation: take by weighing PVB, isobutyltrimethylmethane., ethyl cellulose, the ethyl oleate mix homogeneously of recipe quantity, add the solvent of surplus, mix homogeneously dissolves it fully.
⑶ the abundant mix homogeneously of blank film forming stock solution of the reserve liquid of step ⑴ and step ⑵, and pour into and promptly get the liquid adhesive bandage that contains 5% erythromycin in the sprayer unit.
Embodiment 8
The component and the percentage by weight of the wound spray of present embodiment are following:
Preparation technology is following:
⑴ functional component pre-prepared: take by weighing griseofulvin, rose essence, VA64, the sodium lauryl sulphate mix homogeneously of recipe quantity, add adequate amount of ethanol, in the high speed homogenization dispersion machine, fully disperse the back subsequent use.
⑵ blank film forming stock solution preparation: take by weighing PVB, isobutyltrimethylmethane., ethyl cellulose, the ethyl oleate mix homogeneously of recipe quantity, add the solvent of surplus, mix homogeneously dissolves it fully.
⑶ the abundant mix homogeneously of blank film forming stock solution of the reserve liquid of step ⑴ and step ⑵, and pour into and promptly get the liquid adhesive bandage that contains 3% griseofulvin in the sprayer unit.
Embodiment 9
The component and the percentage by weight of the wound spray of present embodiment are following:
Preparation technology is following:
⑴ functional component pre-prepared: take by weighing lignocaine, rose essence, VA64, the sodium lauryl sulphate mix homogeneously of recipe quantity, add adequate amount of ethanol, in the high speed homogenization dispersion machine, fully disperse the back subsequent use.
⑵ blank film forming stock solution preparation: take by weighing PVB, isobutyltrimethylmethane., ethyl cellulose, the ethyl oleate mix homogeneously of recipe quantity, add the solvent of surplus, mix homogeneously dissolves it fully.
⑶ the abundant mix homogeneously of blank film forming stock solution of the reserve liquid of step ⑴ and step ⑵, and pour into and promptly get the liquid adhesive bandage that contains 3% lignocaine in the sprayer unit.
Embodiment 10
The component and the percentage by weight of the wound spray of present embodiment are following:
Preparation technology is following:
⑴ functional component pre-prepared: take by weighing tannic acid, benzalkonium chloride, Herba Menthae Oleum sesami, VA64, the sodium lauryl sulphate mix homogeneously of recipe quantity, add adequate amount of ethanol, in the high speed homogenization dispersion machine, fully disperse the back subsequent use.
⑵ blank film forming stock solution preparation: take by weighing PVB, isobutyltrimethylmethane., ethyl cellulose, the ethyl oleate mix homogeneously of recipe quantity, add the solvent of surplus, mix homogeneously dissolves it fully.
⑶ the abundant mix homogeneously of blank film forming stock solution of the reserve liquid of step ⑴ and step ⑵, and pour into promptly to get in the sprayer unit and contain 0.5% tannic acid, the liquid adhesive bandage of 0.2% benzalkonium chloride.
Embodiment 11
The component and the percentage by weight of the wound spray of present embodiment are following:
Preparation technology is following:
⑴ functional component pre-prepared: take by weighing silver nitrate, mupirocin, lignocaine, Herba Menthae Oleum sesami, VA64, the sodium lauryl sulphate mix homogeneously of recipe quantity, add adequate amount of ethanol, in the high speed homogenization dispersion machine, fully disperse the back subsequent use.
⑵ blank film forming stock solution preparation: take by weighing PVB, isobutyltrimethylmethane., ethyl cellulose, the ethyl oleate mix homogeneously of recipe quantity, add the solvent of surplus, mix homogeneously dissolves it fully.
⑶ the abundant mix homogeneously of blank film forming stock solution of the reserve liquid of step ⑴ and step ⑵, and pour into and promptly get the liquid adhesive bandage that contains 0.5% silver nitrate, 2% mupirocin and 3% lignocaine in the sprayer unit.
Embodiment 12
The component and the percentage by weight of the wound spray of present embodiment are following:
Preparation technology is following:
⑴ functional component pre-prepared: take by weighing recipe quantity zinc sulfate, erythromycin, lignocaine, Herba Menthae Oleum sesami, VA64,
The sodium lauryl sulphate mix homogeneously adds adequate amount of ethanol, in the high speed homogenization dispersion machine, fully disperses the back subsequent use.
⑵ blank film forming stock solution preparation: the PVB, isobutyltrimethylmethane., ethyl cellulose, the ethyl oleate that take by weighing recipe quantity mix
Close evenly, add the solvent of surplus, mix homogeneously dissolves it fully.
⑶ the abundant mix homogeneously of blank film forming stock solution of the reserve liquid of step ⑴ and step ⑵, and pour in the sprayer unit
Promptly get the liquid adhesive bandage that contains 0.5% zinc sulfate, 5% erythromycin and 3% lignocaine.
Embodiment 13
The component and the percentage by weight of the wound spray of present embodiment are following:
Preparation technology is following:
⑴ functional component pre-prepared: take by weighing procaine, rose essence, VA64, the sodium lauryl sulphate mix homogeneously of recipe quantity, add adequate amount of ethanol, in the high speed homogenization dispersion machine, fully disperse the back subsequent use.
⑵ blank film forming stock solution preparation: take by weighing PVB, isobutyltrimethylmethane., ethyl cellulose, the ethyl oleate mix homogeneously of recipe quantity, add the solvent of surplus, mix homogeneously dissolves it fully.
⑶ the abundant mix homogeneously of blank film forming stock solution of the reserve liquid of step ⑴ and step ⑵, and pour into and promptly get the liquid adhesive bandage that contains 2% procaine in the sprayer unit.
Embodiment 14
The component and the percentage by weight of the wound spray of present embodiment are following:
Preparation technology is following:
⑴ functional component pre-prepared: take by weighing tetracaine, jasmine Oleum sesami, VA64, the sodium lauryl sulphate mix homogeneously of recipe quantity, add adequate amount of ethanol, in the high speed homogenization dispersion machine, fully disperse the back subsequent use.
⑵ blank film forming stock solution preparation: take by weighing PVB, isobutyltrimethylmethane., ethyl cellulose, the ethyl oleate mix homogeneously of recipe quantity, add the solvent of surplus, mix homogeneously dissolves it fully.
⑶ the abundant mix homogeneously of blank film forming stock solution of the reserve liquid of step ⑴ and step ⑵, and pour into and promptly get the liquid adhesive bandage that contains 2.5% tetracaine in the sprayer unit.
Embodiment 15
The component and the percentage by weight of the wound spray of present embodiment are following:
Preparation technology is following:
⑴ functional component pre-prepared: take by weighing bupivacaine, rose essence, VA64, the sodium lauryl sulphate mix homogeneously of recipe quantity, add adequate amount of ethanol, in the high speed homogenization dispersion machine, fully disperse the back subsequent use.
⑵ blank film forming stock solution preparation: take by weighing PVB, isobutyltrimethylmethane., ethyl cellulose, the ethyl oleate mix homogeneously of recipe quantity, add the solvent of surplus, mix homogeneously dissolves it fully.
⑶ the abundant mix homogeneously of blank film forming stock solution of the reserve liquid of step ⑴ and step ⑵, and pour into and promptly get the liquid adhesive bandage that contains 4% bupivacaine in the sprayer unit.
Embodiment 16
The component and the percentage by weight of the wound spray of present embodiment are following:
Preparation technology is following:
⑴ functional component pre-prepared: take by weighing ropivacaine, ibuprofen, rose essence, VA64, the sodium lauryl sulphate mix homogeneously of recipe quantity, add adequate amount of ethanol, in the high speed homogenization dispersion machine, fully disperse the back subsequent use.
⑵ blank film forming stock solution preparation: take by weighing PVB, isobutyltrimethylmethane., ethyl cellulose, the ethyl oleate mix homogeneously of recipe quantity, add the solvent of surplus, mix homogeneously dissolves it fully.
⑶ the abundant mix homogeneously of blank film forming stock solution of the reserve liquid of step ⑴ and step ⑵, and pour into and promptly get the liquid adhesive bandage that contains 3% ropivacaine, 1% ibuprofen in the sprayer unit.
Embodiment 17
1, film body elasticity research
Prescription sees that table 1, the said percentage ratio of following table are mass percent (wherein PVB is a polyvinyl butyral, and PVA is a polyvinyl alcohol)
Process for preparation is following:
1) preparation of ethyl cellulose:, subsequent use with ethyl cellulose abundant swelling in adequate amount of ethanol solution of recipe quantity.
2) preparation of polyvinyl alcohol:, subsequent use with polyvinyl alcohol abundant swelling in suitable quantity of water of recipe quantity.
3) prescription 1 and contrast 1 preparation: with the ethyl cellulose solution mix homogeneously that polyvinyl butyral, ethyl oleate, isobutyltrimethylmethane., the step 1) of recipe quantity makes, add the ethanol of surplus, fully dissolving promptly gets.
4) prescription 2 and contrast 2 preparation: with the swelling solution of the polyvinyl alcohol 0588 of the ethyl oleate of recipe quantity, isobutyltrimethylmethane., step 1 and the ethyl cellulose solution that step 1) makes, add the second alcohol and water of surplus, fully dissolving promptly gets.
5) prescription 3 and contrast 3 preparation: with the swelling solution of the polyvinyl alcohol 1788 of the ethyl oleate of recipe quantity, isobutyltrimethylmethane., step 1 and the ethyl cellulose solution that step 1) makes, add the second alcohol and water of surplus, fully dissolving promptly gets.
Detection method is following:
With the film forming stock solution of prescription 1-3 and contrast 1-3, take out 2 grams pour in the rectangle glass case of long 2cm inner width 0.8cm, at room temperature place 2 hours after, make film forming complete.Take out film body, prune the film body edge with blade and make its growth 1.8cm, the thin slice of wide 0.6cm; And entirely be placed on the sheet glass; One is fixed on graduated sheet glass edge, and an effect of removing pulling force after stretching 1 minute with the pulling force of 20N, 40N, 60N respectively recovers after 5 minutes it, measures the film body length before and after stretching respectively; Observe the distortion situation of film body, and measure the elasticity rate of change of film.The result sees table 2:
Can find out from the contrast of above-mentioned prescription 1-3 and contrast side 1-3,
1) through adding ethyl cellulose, makes the more high resilience of its film body.Therefore add the elasticity that ethyl cellulose helps to increase film body.
2) from above-mentioned prescription 1-3, can find out that ethyl cellulose is more suitable to polyvinyl butyral.
2, viscosity adjustment research
The liquid adhesive bandage when using injection apparatus because the surface tension and the too high sprayer unit that causes using common press type of viscosity of material.Liquid rerum natura through to classics can be recognized the influence in dispersed jet liquid droplet footpath; Under high surface tension and full-bodied situation; Expect that very little SMD (average liquid droplet footpath) must increase impelling pressure and reduce nozzle diameter; This will increase substantially production cost, is unfavorable for Products Development.Therefore in order to be designed to the sprayer unit of common press type, need to reduce viscosity and surface tension to pleurodiaphragmatic in terspace liquid.
Selecting for use on the viscosity adjustment, tentatively selecting for use polyoxyethylene hydrogenated Oleum Ricini, liquid paraffin, low viscosity dimethicone, ethyl oleate, triglyceride as the plasticising adjusting adhesive.
The result sees table 3, and the said percentage ratio of following table is mass percent (PVB is a polyvinyl butyral, and EC is an ethyl cellulose)
Can find out that from table 3 ethyl oleate is more suitable to the adjusting of viscosity, further the preferred oil acetoacetic ester is as the plasticising adjusting adhesive, and concentration is controlled at 0 ~ 8%, further optimizes concentration and is controlled at 3 ~ 6%.
3, anti-stick research
The requirement of liquid adhesive bandage is film forming in 1 minute; This will produce other a kind of unfavorable factor, promptly after injection, understands residual stock solution in the above at spray valve, and film forming causes spray valve to stop up at once; Find that through studying us isobutyltrimethylmethane. can not only quicken the volatilization of pleurodiaphragmatic in terspace liquid; And lubricated spray valve prevents to stop up valve, and concentration is controlled at 1 ~ 20%, further optimizes concentration and is controlled at 3 ~ 10%.And realize through following method.During film forming stock solution is packed the spray bottle in will filling a prescription, whenever sprayed 3 times, observe jet power and droplet spray pattern at a distance from 5 minutes.Formula table is seen table 4, and the result sees table 5.
Recipe is following:
1) preparation of ethyl cellulose:, subsequent use with ethyl cellulose abundant swelling in adequate amount of ethanol solution of recipe quantity;
2) preparation of prescription 1: with polyvinyl butyral, ethyl cellulose solution, ethyl oleate, the isobutyltrimethylmethane. mix homogeneously of recipe quantity, add the ethanol of surplus, fully dissolving promptly gets;
3) preparation of contrast 1: with polyvinyl butyral, ethyl cellulose solution, ethyl oleate, the mix homogeneously of recipe quantity, add the ethanol of surplus, fully dissolving promptly gets.
4, the pharmacological datum of wound healing ability
Generally speaking, scratch takes about 3 days and could form a scab under the situation of the protection of traditional adhesive bandage, could heal fully about 2 weeks.
The present invention has carried out significant improvement with respect to existing adhesive bandage technology, understands the mode of accelerating wound more, and making of designing in such a way it is ventilative, fungi-proofing, antibacterial more, bioadhesive is good, can the moistening wound.
The liquid adhesive bandage that contains 0.2% benzalkonium chloride with embodiment 1 carries out pharmacological research.
4.1 the wound healing situation is observed
Abrasive situation is as shown in Figure 1; Use the wound incrustation situation after 1 day as shown in Figure 2; Use the wound healing situation after 5 days as shown in Figure 3.
From accompanying drawing 1 ~ 3, we can find out that the healing rate of wound is obviously accelerated, and explain that these article have facilitation to the healing of wound.
From accompanying drawing 4 ~ 6, we can find out that these article have good hydrophobicity, and biocompatibility is non-stimulated to wound, do not have irritated reaction, can well protect wound.
4.2 the bactericidal effect of liquid adhesive bandage of the present invention, prior art liquid adhesive bandage, traditional adhesive plaster adhesive bandage and 0.2% Benza is contrasted, and the result sees table 6
From table 6, can find out clearly that liquid adhesive bandage of the present invention all has the obvious sterilization effect with respect to other adhesive bandages, and can obviously strengthen the sterilizing ability of benzalkonium chloride.
Claims (4)
1. one kind is used to treat abrasive wound spray; It is characterized in that; Form by functional component and blank film forming stock solution; Said functional component is selected from one or more in disinfectant for external use, topical antibiotic, local anesthetic and the skin contraction composition, and said blank film forming stock solution comprises polyvinyl butyral, coalescents, plasticising adjusting adhesive, surfactant, helps volatilization antiplastering aid, porogen, aromatic and solvent;
Each composition shared mass percent in the wound spray is following:
2. according to claim 1ly be used to treat abrasive wound spray, it is characterized in that said disinfectant for external use is selected from polymer, acrylic disulfide or the acrylic trithioether of benzalkonium chloride, benzalkonium bromide, iodine, iodine; Said topical antibiotic is selected from mupirocin, erythromycin or griseofulvin; Said local anesthetic is lignocaine, procaine, tetracaine, bupivacaine, ropivacaine or ibuprofen; Said skin contraction composition is selected from tannic acid, silver nitrate or zinc sulfate.
3. according to claim 1ly be used to treat abrasive wound spray, it is characterized in that said coalescents is an ethyl cellulose; Said plasticising adjusting adhesive is selected from ethyl oleate, triethyl citrate, diethyl phthalate, dimethyl phthalate, dibutyl phthalate or silicone oil and derivant thereof; Said surfactant is a sodium lauryl sulphate; Said help the volatilization antiplastering aid be isobutyltrimethylmethane.; Said porogen is polyvinylpyrrolidone-vinyl acetate co-polymer or polyvinylpyrrolidone; Said aromatic is rose essence, Flos Jasmini Sambac Oleum sesami, wintergreen oil, Oleum menthae or Eucalyptus oil; Said solvent is one or several in ethanol, ethyl acetate, acetone, the propylene glycol.
4. describedly be used to treat abrasive wound spray preparing process like claim 1 or 2 or 3, it is characterized in that, comprise the steps:
1) functional component pre-prepared: take by weighing functional component, aromatic, porogen, the surfactant mix homogeneously of recipe quantity, add proper amount of solvent, in the high speed homogenization dispersion machine, fully disperse the back subsequent use;
2) blank film forming stock solution preparation: take by weighing recipe quantity polyvinyl butyral, plasticising adjusting adhesive, coalescents, help volatilization antiplastering aid mix homogeneously, add the solvent of surplus, mix homogeneously dissolves it fully;
3) with the reserve liquid and the step 2 of step 1)) the abundant mix homogeneously of blank film forming stock solution, and pour in the sprayer unit and promptly get.
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| CN106563129A (en) * | 2016-10-31 | 2017-04-19 | 江苏长泰药业有限公司 | Composition for wound protection and dressing formed by composition |
| CN107616971A (en) * | 2017-08-16 | 2018-01-23 | 稳健医疗用品股份有限公司 | A kind of liquid spray bandage, wound spray liquid and preparation method thereof |
| CN105363066B (en) * | 2015-11-30 | 2018-07-06 | 江苏华能药业有限公司 | A kind of liquid adhesive bandage |
| EP3613405A4 (en) * | 2017-04-19 | 2021-01-13 | Kao Corporation | Method for forming coating film |
| CN113181420A (en) * | 2021-05-07 | 2021-07-30 | 多能干细胞再生医学科技（广州）有限公司 | Liquid wound dressing for quickly repairing skin superficial injury and preparation method thereof |
| WO2022133626A1 (en) * | 2020-12-21 | 2022-06-30 | 江苏奇力康皮肤药业有限公司 | Rapid film-forming liquid band-aid and preparation method therefor |
| WO2022133629A1 (en) * | 2020-12-21 | 2022-06-30 | 江苏奇力康皮肤药业有限公司 | Spray type liquid bandage and preparation method therefor |
| EP4255994A4 (en) * | 2020-12-01 | 2024-10-02 | Polyamyna Nanotech Inc. | CLEAR ANTIMICROBIAL COATING COMPOSITIONS, METHODS OF PREPARATION AND USES THEREOF FOR IMPLEMENTING ANTIMICROBIAL EFFECT TO A SURFACE |
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| CN113181420A (en) * | 2021-05-07 | 2021-07-30 | 多能干细胞再生医学科技（广州）有限公司 | Liquid wound dressing for quickly repairing skin superficial injury and preparation method thereof |
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