CN102772747A - Traditional Chinese medicine preparation for treating heat-toxicity heart-disoperation type viral myocarditis - Google Patents

Abstract

The invention provides a traditional Chinese medicine preparation for treating heat-toxicity heart-disoperation type viral myocarditis. The traditional Chinese medicine preparation comprises the following medicinal raw materials in parts by weight: 10-20 parts of radix ophiopogonis, 10-20 parts of the root of red-rooted salvia, 10-20 parts of carthamus tinctorius, 10-20 parts of root of common peony, 10-20 parts of schisandra chinensis, 10-20 parts of pseudo-ginseng, 10-20 parts of astragalus mongholicus, 10-20 parts of trogopterus dung, 10-20 parts of rhizoma atractylodis, 10-20 parts of vegetable sponge, 10-20 parts of ligusticum wallichii, 10-20 parts of curcuma zedoary, 10-20 parts of scutellaria baicalensis, 10-20 parts of polygala tenuifolia, 10-20 parts of lumbricus, 10-20 parts of angelica sinensis, 10-20 parts of isatis root, 10-20 parts of folium isatidis, 10-20 parts of honeysuckle, 10-20 parts of fructus forsythiae, 10-20 parts of mint, and 10-20 parts of cape jasmine. The traditional Chinese medicine preparation disclosed by the invention is capable of rapidly in-flowing blood, directly achieving myocardium, rapidly increasing myocardial contraction force, tonifying qi, nourishing yin, invigorating blood circulation, removing stasis, calming the mind, soothing the liver and reducing heat and has the main functions of detoxifying, removing stasis, clearing heat, opening the inhibited lung-energy and clearing away the heart-fire; therefore, the function of rapidly relieving patient conditions can be achieved.

Description

A kind ofly treat the Chinese medicine preparation that pyretic toxicity is invaded heart type viral myocarditis

Technical field

The present invention relates to contain the medicinal preparation that derives from plant, animal or mineral component, particularly a kind ofly treat the Chinese medicine preparation that pyretic toxicity is invaded heart type viral myocarditis.

Background technology

Viral myocarditis is one type of the most common clinically, that number of the infected is maximum myocarditis; Has popularity; Risen more than 10 times than sickness rate before 10 years now; Become the modal cardiomyopathy of China, pilosity be born among the crowd viral infection popular in, have 5% patient cause viral myocarditis approximately on the virus infected flow departure date.In recent years, the understanding of viral myocarditis is constantly deepened.Can cause that myocarditic virus is a lot; As: Coxsackie virus, adenovirus, influenza virus or the like; The myocarditis that wherein causes with change of coxsackie b virus especially sees that at most because cardiac muscle is responsive especially to this virus performance, myocardium has special affinity to this virus.

After the patient infection Coxsackie virus, 5% the heart that involves is arranged approximately.Focal necrosis all can take place in heart myocardial cell everywhere; With inflammatory cell infiltration, mainly be mononuclear cell in the necrosis region, neutrophilic granulocyte is also arranged sometimes, inflammatory cell reaction sometimes is not obvious.Necrosis region finally replaces for fibrosis, and the clinical manifestation of children virus myocarditis is grown up serious.Viral myocarditis does not have specific treatment so far, and modern medicine generally all is to adopt to suit the medicine to the illness and supporting treatment.Be mainly and alleviate the heart burden, take a good rest and nutrition; Carry out symptomatic treatment to symptoms such as the heart failure that occurs, arrhythmia simultaneously, and cardiac nutrition, the myocardial metabolism of improving, adrenocortical hormone used sometimes.

After the increased in acute viral myocarditis, usually need convalescent treatment for a long time, half a year at least, have in addition 1-2, or longer a period of time.It is exactly the liver-fire superinverse that pyretic toxicity is invaded heart type myocarditis, and pathogenic fire is admired the myocarditis that causes, disease is seen pharyngalgia, fever and cough, and sensation of oppression over the chest with shortness of breath, cardiopalmus is vexed, red tip of the tongue, yellow and thin fur, thready and rapid pulse, clinical common.

Recent study is found, utilizes combination of Chinese and Western medicine method treatment viral myocarditis to receive gratifying effect.Therefore, Chinese medicine is for the improvement of viral myocarditis at symptom control, cardiac function, and the recovery of cardiac muscle and the adjusting aspect of whole machine body function have obtained the approval of extensive patients.Through a large amount of zooperies and clinical observation, prove that myocarditis is to be caused by multiple virus.Modal is Coxsackie virus B6, and other also possibly cause a disease like Coxsackie virus A, EcHo virus, poliovirus, influenza and parainfluenza virus, mumps virus, chickenpox virus, herpes simplex virus, varicella zoster virus and hepatitis virus etc.The etiopathogenesis of viral myocarditis is not understood so far fully, and propounding a theory at present mainly contains viral theory, immunological theory and biochemical mechanism theory etc.Most evidences show that its pathological process can be divided into two stages: be mainly the coup injury of viral infection to myocardial cell in early days; Along with the progress of the course of disease, viral infection can excite the immunopathogenesis process, thereby increases the weight of or cause new myocardial damage, and this process is slow and lasting.

At present, modern medicine does not still have the efficacious therapy method to viral myocarditis.The clinical manifestation of viral myocarditis has nothing in common with each other, and myocarditic symptom possibly come across the symptom phase or the convalescent period of protopathy, and as occurring in symptom phase of protopathy, its performance can be covered by protopathy.Most of patients has symptoms such as heating, systemic pain, pharyngalgia, diarrhoea at premorbid, reflection general viral infection, but part patient protopathy mild symptoms is also arranged and not remarkable, and carefully the side of questioning closely is noted, the myocarditis symptom is then relatively significantly.

That myocarditis patient often tells is uncomfortable in chest, pareordia dull pain, cardiopalmus, weak, nauseating, dizzy.Clinically in the myocarditis of diagnosis, about 90% are chief complaint or head sees symptom with arrhythmia, and wherein small number of patients can take place to faint or Adams Stokes syndrome therefrom.Only a few patient rises after being ill, and development heart failure or cardiogenic shock occur rapidly.There is 60%～88% patient about morbidity the last fortnight, to have on heating, pharyngalgia, the general pain etc. pioneer such as sense or diarrhoea present approximately; Viral myocarditis has become the commonly encountered diseases in medical science internal medicine field; Hazardness is very big, but does not still have the Chinese medicine preparation of drug administration by injection safely and effectively so far; Do not have effective experience side clinically, flavour of a drug are more, and all adopt decoct oral, also do not have the Chinese medicine injection dosage form, and are slow to drug absorption for the more not only body of peroral dosage form, and use also inconvenient.Directly have influence on the therapeutic effect and the scope of application of the type medicine.

During this disease of clinical treatment, measures such as main employing anti-bolt medicine, nitrate esters medicine and bypass surgery treatment.The then Western medicine antibiotic that adopt of viral myocarditis more, for example oral ribavirin, intravenous injection inosine, aspara, vitamin C etc., its general effect is not obvious, and cure rate is low, and toxic and side effects is big.Western medical treatment is main with chemotherapy still, and treatment cycle is long, and side effect is big; Uncertain therapeutic efficacy is cut, and is difficult for adhering to, traditional Chinese medical science traditional therapy does not have the Chinese medicine of special treatment to come out yet; Do not have effective experience side clinically, flavour of a drug are more, and all adopt decoct oral; Also there is not the Chinese medicine injection dosage form, slow for the more not only body of peroral dosage form to drug absorption, and use also inconvenient.

Summary of the invention

Technical problem to be solved by this invention is, provides a kind of pyretic toxicity of treating to invade Chinese medicine preparation of heart type viral myocarditis and preparation method thereof, and the medicine of invading heart type viral myocarditis to present treatment pyretic toxicity remains in many deficiencies; Like western medical treatment is main with chemotherapy still, and treatment cycle is long, and side effect is big; Uncertain therapeutic efficacy is cut, and is difficult for adhering to, traditional Chinese medical science traditional therapy does not have the Chinese medicine of special treatment to come out yet; Do not have effective experience side clinically, flavour of a drug are more, and all adopt decoct oral; Also there is not the Chinese medicine injection dosage form, slow for the more not only body of peroral dosage form to drug absorption, and use also inconvenient.

For solving the problems of the technologies described above, the present invention provides a kind of Chinese medicine preparation that pyretic toxicity is invaded heart type viral myocarditis of treating, and the ratio of weight and number of various crude drug is in the said Chinese medicine preparation: 10～20 parts of Radix Ophiopogonis, 10～20 parts of Radix Salviae Miltiorrhizaes; 10～20 parts on Flos Carthami, 10～20 parts of Radix Paeoniae Rubra, 10～20 parts of Fructus Schisandrae Chinensis, 10～20 parts of Radix Notoginseng; 10～20 parts of the Radixs Astragali, 10～20 parts of Oletum Trogopteroris, 10～20 parts of Rhizoma Atractylodis, 10～20 parts of Retinervus Luffae Fructuss; 10～20 parts of Rhizoma Chuanxiongs, 10～20 parts of Rhizoma Curcumae, 10～20 parts of Radix Scutellariaes, 10～20 parts of Radix Polygalaes; 10～20 parts of Pheretimas, 10～20 parts of Radix Angelicae Sinensis, 10～20 parts of Radix Isatidis, 10～20 parts of Folium Isatidiss; 10～20 parts of Flos Loniceraes, 10～20 parts of Fructus Forsythiaes, 10～20 parts of Herba Menthaes, 10～20 parts of Fructus Gardeniaes.

Said treatment pyretic toxicity is invaded the Chinese medicine preparation of heart type viral myocarditis, and the ratio of weight and number of various crude drug can also be 10～15 parts of Radix Ophiopogonis, 10～15 parts of Radix Salviae Miltiorrhizaes, 10～15 parts on Flos Carthami, 10～15 parts of Radix Paeoniae Rubra in the said Chinese medicine preparation; 10～15 parts of Fructus Schisandrae Chinensis, 10～15 parts of Radix Notoginseng, 10～15 parts of the Radixs Astragali, 10～15 parts of Oletum Trogopteroris, 10～15 parts of Rhizoma Atractylodis; 10～15 parts of Retinervus Luffae Fructuss, 10～15 parts of Rhizoma Chuanxiongs, 10～20 parts of Rhizoma Curcumae, 10～20 parts of Radix Scutellariaes, 10～20 parts of Radix Polygalaes; 10～20 parts of Pheretimas, 10～20 parts of Radix Angelicae Sinensis, 10～20 parts of Radix Isatidis, 10～20 parts of Folium Isatidiss; 10～20 parts of Flos Loniceraes, 10～20 parts of Fructus Forsythiaes, 10～20 parts of Herba Menthaes, 10～20 parts of Fructus Gardeniaes.

Said treatment pyretic toxicity is invaded the Chinese medicine preparation of heart type viral myocarditis, and the ratio of weight and number of various crude drug also can be 10～20 parts of Radix Ophiopogonis, 10～20 parts of Radix Salviae Miltiorrhizaes, 10～20 parts on Flos Carthami, 10～20 parts of Radix Paeoniae Rubra in the said Chinese medicine preparation; 10～20 parts of Fructus Schisandrae Chinensis, 10～20 parts of Radix Notoginseng, 10～20 parts of the Radixs Astragali, 10～20 parts of Oletum Trogopteroris, 10～20 parts of Rhizoma Atractylodis; 10～20 parts of Retinervus Luffae Fructuss, 10～20 parts of Rhizoma Chuanxiongs, 10～15 parts of Rhizoma Curcumae, 10～15 parts of Radix Scutellariaes, 10～15 parts of Radix Polygalaes; 10～15 parts of Pheretimas, 10～15 parts of Radix Angelicae Sinensis, 10～15 parts of Radix Isatidis, 10～15 parts of Folium Isatidiss; 10～15 parts of Flos Loniceraes, 10～15 parts of Fructus Forsythiaes, 10～15 parts of Herba Menthaes, 10～15 parts of Fructus Gardeniaes.

For solving the problems of the technologies described above; The present invention provides a kind of method for preparing that pyretic toxicity is invaded the Chinese medicine preparation of heart type viral myocarditis of treating; The dosage form of said Chinese medicine preparation comprises for the method for preparing of honey refining pill: earlier said crude drug is ground into coarse powder, further pulverizes, cross 100 orders～120 mesh sieves; The fine powder amount that enable pass is sieved is reaching 20 ~ 30%, and the fine powder of collecting through sieve gets fine powder a; Can not drop into multi-function extractor through the coarse powder of 120 mesh sieves again and extract twice, and add 5-10 times of water gaging for the first time and decocted 1-2 hour, and add 5-10 for the second time and doubly measured ethanol extraction 1-2 hour, merge decocting liquid twice, and cross and filter filtrating; Heating is concentrated into pasty state, puts into 80 ℃ of oven dry of baking oven postcooling, grinds to form fine powder b, with a, calls in Mel after b mixes and processes honey refining pill.

For solving the problems of the technologies described above, the present invention provides a kind of method for preparing that pyretic toxicity is invaded the Chinese medicine preparation of heart type viral myocarditis of treating, and the dosage form of said medicine is that the method for preparing of capsule comprises:

A, get crude drug and add water extraction 2 times, become the extractum shape, be component 1;

It is the extractum shape that b, medicinal residues add the ethanol thickening filtration, is component 2;

C, two kinds of component extractum are mixed pulverize, it is an amount of to add dextrin, mixing, fill capsule.

Among the said step a, can get crude drug and add water logging bubble 1-2 hour that 5-10 doubly measures, extract 2 times; Heating extraction 1-2 hour, be concentrated into the extractum shape, become component 1.

Among the said step b, can medicinal residues be added the 60-90% soak with ethanol 1-2 hour, extract twice, each 0.5-1 hour; Merge extractive liquid, filters, and concentrates; The 80-160 order filters, and the 6000-10000 rev/min of supernatant after centrifugal is the ultrafiltration post ultrafiltration of 5000-10000 through the molecular weight that dams; 1.38 extractum when ultrafiltrate concentrating under reduced pressure relative density is 80 ℃, heating and refluxing extraction 2 times, each 30 minutes～45 minutes; Extract active ingredient, with twice 7, merge according to extracting solution among the b of step described in the claim 5 and to settle into the extractum shape, as component 2;

Among the said step c, can two kinds of component extractum be pulverized and mix, the adding dextrin is an amount of, puts into the hothouse drying, and hot stream temperature is 80 ℃-100 ℃, gets raw material medicated powder, incapsulates patent medicine.

For solving the problems of the technologies described above; The present invention provides a kind of method for preparing that pyretic toxicity is invaded the Chinese medicine preparation of heart type viral myocarditis of treating; The dosage form of said medicine is that the method for preparing of drop pill comprises: with Pheretima, Rhizoma Curcumae, Rhizoma Chuanxiong and Radix Notoginseng add the water that its weight sum 5-7 doubly measures, and put into multi-function extractor according to said component ratio of weight and number; Keep air pressure to decoct 2 hours, extract its water soluble ingredient at 0.04-0.06mPa; Extracting liquid filtering 100 mesh sieves; With the refining filtrating of adsorbent resin back ethanol elution; Eluent is evaporated to density 1.33-1.35, and wherein input air pressure is 0.04-0.06mPa, and vacuum is-0.076 ~-0.088 mPa, stand for standby use; All the other components add the water that its weight sum 5-7 doubly measures; Put into multi-function extractor, maintenance air pressure is 0.04-0.06mPa, decocts 2 hours; The filter extracting solution is crossed 100 mesh sieves; Vacuum concentrated filtrate is to crude drug amount 1: 1W/V; Concentrated solution adds ethanol precipitation; Ethanol precipitation liquid filters with 100 mesh sieves; The use sephadex chromatography is refining, uses ethanol elution; Eluent is concentrated into density 1.33-1.35, leaves standstill; Get above-mentioned two kinds leave standstill drop go into cool off in the dimethicone drop pill.

For solving the problems of the technologies described above; The present invention provides a kind of dosage form that pyretic toxicity is invaded the Chinese medicine preparation of heart type viral myocarditis of treating, and its pharmaceutical dosage form comprises: tablet, sugar coated tablet, film coated tablet, enteric coated tablet, capsule, hard capsule, soft capsule, oral liquid, suck agent, granule, electuary, honey pill agent, powder, sublimed preparation, solution, injection, suppository, plaster, syrup, drop pill or extractum.

Compared with prior art, the extract of the inventive method acquisition is convenient to the preparation of solid preparation.When extract of the present invention was prepared into solid preparation, usually extracting solution must the spray-dried extract powder that becomes, and granulate, thereby supplementary product consumption in the minimizing preparation reduces clinical taking dose again.If the sample liquid behind the water extract-alcohol precipitation is carried out spray drying, very easily sticking wall is difficult to obtain dried powder, and loss is very big, even obtain powder, because of hygroscopicity is very strong, also is difficult to process granule, makes troubles for the preparation of solid preparation.And the present invention through ultracentrifugal medicinal liquid because to remove impurity comparatively thorough, concentrate, after the spray drying, can obtain dry loose powdered, the back yield rate of granulating is high, can be suitable for large-scale production.

Drop pill machine technology parameter is following: the drip irrigation temperature keeps 85-95 ℃, and condensed fluid liquid paraffin temperature is lower than 8 ℃, and the water dropper internal diameter is 1.6mm, and the water dropper external diameter is 2.5mm, and water dropper is 15cm apart from the liquid paraffin surface distance; Centrifugal, rotating speed 800-1100rpm after 15 minutes, removes deparaffnize and gets final product.Be quick acting, drop pill of the present invention is made into to dissolve the piller of absorption in the Sublingual rapidly, and it can go into blood fast, and through cardiac muscle strengthens myocardial contraction rapidly, coronary blood flow increasing, and protecting myocardial cell improves cardiac function.

This invention beneficial technical effects is exactly: use the myocarditic medicine of selected Chinese medicinal material preparation treatment; The medicine of processing can not only improve myocardial metabolism, cardiac nutrition, protection heart cell; Improve the resistance against diseases of cardiac muscle; And ability direct killing virus, alleviate virus to induced myocardial injury, play antiviral and the integrally-regulated action effect that combines; Alleviate the Western medicine prolonged application to the side effect that human body produces, make it become the ideal myocarditic medicine that is used to treat, the present invention contains a large amount of active component, and raw material is cheap, and method for preparing is simple, can apply in the clinical practice in a large number.The present invention can go into blood fast, and through cardiac muscle strengthens myocardial contraction rapidly, and eliminating toxic substances to remove stasis, reducing heat and dispersing lung-QI, and it is main that detoxifcation clears away heart-fire; Supplementing QI and nourishing YIN, or supplementing QI and nourishing YIN and blood circulation promoting and blood stasis dispelling share, or QI invigorating mind calming and soothing the liver expelling the heat-evil share, or the Yangfu(jing-River point,GB 38) that helps heart kidney reaches rapid mitigate the disease with methods such as the diuretic that reduces phlegm, saves the effect of sufferer life.And raw material is cheap, and method for preparing is simple, can apply in the clinical practice in a large number.Treatment by Chinese herbs ability treating both the principal and secondary aspects of a disease, safety, effective, medical expense is lower.The present invention is easy to use, and cheap, and is easy to use, can create good social and be worth and economic interests.

The specific embodiment

Viral myocarditis relates to categories such as the traditional Chinese medical science " cardiopalmus ", " palpitation with a distress feeling ", " thoracic obstruction "; The Chinese medicine viral myocarditis has special advantages; According to for many years the treatment experience of this disease and experimentation being confirmed; Holding concurrently with the detoxifcation with supplementing QI and nourishing YIN, blood circulation promoting and blood stasis dispelling, calming heart and tranquilizing mind is method, and treatment is with syndrome of deficiency of both qi and yin or to hold the stasis of blood under the arm be that the viral myocarditis effect of main clinical manifestation is preferable.

Viral myocarditis is clinical more common cardiac disorder, is mainly in teenager and middle age.Be to violate by evil poison is outer, the interior house due to the heart, mainly show as cardiopalmus, uncomfortable in chest, breathe hard, disease such as weak, arrhythmia, belong to motherland's medical science " cardiopalmus " " palpitation with a distress feeling " " thoracic obstruction " categories such as " asthenia " more.The heart occupies in the heart, controlling blood and vessel, house mind.At body is arteries and veins, and arteries and veins is the house of blood.In battalion's row arteries and veins, defensive QI circulating outside the vessel, battalion defends root in middle Jiao, can be in cardiopulmonary.Exopathogen invasion and attack, chief criminal battalion defends, and it is evil to stagnate and does not loose, and stays and does not go, or go and not to the greatest extent, can follow sering, the interior house in the heart." qi being the governor of blood, blood being the material foundation of QI " again, the deficiency of vital energy is then agitated unable, and the blood deficiency then heart is lost and to be moistened fosterly, all can form primary disease.Sui's Chao Yuanfang (550-630 A.D.) " General Treatise on the Cause and Symptoms of Diseases " is said: " wind palpitation with fear person, empty by body, deficiency of heart-QI, the mansion of the heart is taken advantage of by ailment said due to cold or exposure, or frightened melancholy compels, and makes us the deficiency of vital energy, also receives in ailment said due to cold or exposure, ailment said due to cold or exposure is fought in the heart, and is then frightened from peace, shy endlessly then startle indefinite." " warm pathogen tend to attack the upper orifices, attacking the lung first, the pathogen attacking the pericardium adversely." so primary disease at the beginning of, see that evil poison attacks the disease of the criminal's of showing lung more, give up in the heart in the pathogen that continues, and occur that the motive is disturbed, qi-blood disharmony, the cloudy impaired all cards of gas of the heart.Mostly primary disease is that cardiopulmonary are with sick in early days.Disease to middle and late stage then mainly shows as the QIYINLIANGXU of the heart or the syndrome of QI and blood retardance.Difference such as factor body or inducement are also arranged, show as the gas YANG deficiency; Accumulate in the phlegm-damp; Liver and gall are hot and suffocating, deficiency of heart-QI; Or deficiency of heart-YANG and kidney-YANG, disease persons such as the heart attacked by pathogenic water.The sick position of primary disease is at the heart in a word, and holds concurrently and he is dirty.Pathogenesis belongs to void or deficiency in origin and excess in superficiality, and is mostly the simulataneous insufficiency and excessive syndrome.The common Q-T of electrocardiogram interval, prolong, and the T popin is smooth or be inverted various arrhythmia such as frequent premature beat, I, the atrioventricular block of II degree, sinus tachycardia etc.For the treatment of primary disease, the initial stage, it was main that detoxifcation clears away heart-fire with reducing heat and dispersing lung-QI; Middle and late stage is then biased respectively with supplementing QI and nourishing YIN according to the prosperity and decline of negative and positive of qi and blood, or supplementing QI and nourishing YIN and blood circulation promoting and blood stasis dispelling share, or QI invigorating mind calming and soothing the liver expelling the heat-evil share, or the Yangfu(jing-River point,GB 38) that helps heart kidney is with methods such as the diuretic that reduces phlegm.

Radix Angelicae Sinensis invigorating the spleen and replenishing QI in the side, spermatogenesis nourishes blood; Radix Astragali tonifying Qi and lifting yang, the diuretic detumescent; Flos Carthami, Radix Salviae Miltiorrhizae and pseudo-ginseng blood-circulation-invigovating blood stasis dispelling; Rhizoma Curcumae promoting the circulation of QI the chest stuffiness relieving; The tangible coronary dilating of ginsenoside's tool, heart tonifying, reinforcement myocardial contraction, increase cardiac output, reduction myocardial oxygen consumption, reduction blood viscosity and peripheral vascular resistance effect; Simultaneously can reduce and eliminate oxygen-derived free radicals; Thereby the protection cardiac muscle is avoided ischemic injuries, invigorating the heart and spleen.All medicines share, and play altogether that spleen reinforcing is nourished heart, the merit of promoting the circulation of QI to induce diuresis, blood circulation promoting and blood stasis dispelling.Pharmacological research shows that the Radix Astragali has positive inotropic action, contains glucuronic acid, choline etc., can expand peripheral blood vessel, brings high blood pressure down, and strengthens myocardial contractility, improves cardiac output, can suppress the acid of platelet di-phosphate ester simultaneously, microcirculation improvement; But Radix Angelicae Sinensis, Flos Carthami, Radix Salviae Miltiorrhizae decreased heart rate increase coronary flow, and resisting myocardial ischemia strengthens myocardial contraction; But the Radix Polygalae arrhythmia reduces heart rate, significantly reduces the arterial pressure peak value; Rhizoma Chuanxiong, the calm diuresis of ability Radix Ophiopogonis, blood vessel dilating improves coronary circulation.Radix Angelicae Sinensis, Rhizoma Chuanxiong, Radix Paeoniae Rubra, Rhizoma Atractylodis, Flos Carthami, Radix Salviae Miltiorrhizae are the article of activating blood circulation and dissipating phlegm, to reach the effect of blood circulation promoting and blood stasis dispelling, regulating qi and dredging collateral.But the general medical history of the thoracic obstruction patient normal simulataneous insufficiency and excessive of length is to suffer from, and is so-called empty, not the void thanks to of exogenous QI, blood, yin, yang; Real is the stagnation of QI, turbid, the cold coagulation of expectorant often, so clinical need on essential drugs, with the card plus-minus, are executed flexibly and controlled.Research shows, patients with coronary heart disease shows as that the deficiency of vital energy, blood stasis, expectorant are turbid more, cold coagulation or the deficiency of YIN, the stagnation of QI etc., but is main symptom with the blood stasis due to qi deficiency.Pheretima, activating blood circulation to dissipate blood stasis and dredge the collateral in the BENTONG heart side; The Radix Astragali, replenishing qi and promoting blood flow, the temperature gas that activates yang is to strengthen the merit of promoting blood circulation to remove obstruction in the collateral; The Fructus Schisandrae Chinensis QI invigorating and body resistance strengthening is strengthened resistance.All medicines share and play the effect that promoting blood circulation to remove obstruction in the collateral, QI invigorating activate yang, giving consideration to both the incidental and fundamental altogether.Modern pharmacological research confirms, Radix Paeoniae Rubra ability anticoagulant and thrombosis, and microcirculation improvement increases coronary blood flow; The extract of the Radix Astragali has cardiotonic, can improve heart stroke and cardiac index, and the Retinervus Luffae Fructus detoxifcation has effects such as blood vessel dilating, blood pressure lowering, microcirculation improvement simultaneously; Fructus Gardeniae has blood vessel dilating, excited heart, strengthens the effect of coronary blood flow and myocardial contraction.

The Radix Astragali is main with tonify deficiency, ability invigorating QI to consolidate the body surface resistance, diuresis poison holding, evacuation of pus, expelling pus and promoting granulation.Be used for that insufficiency of vital energy and blood, skin infection cave in, difficulty in discharging of pus or burst for a long time and do not hold back the person.The Radix Astragali has the function of good promoting pus discharge and tissue regeneration strengthening, i.e. the abscess suppuration granulation promoting of disunion for a long time.Modern medicine study shows, the Chinese medicine astragalus sweet in the mouth, and tepor is returned the lung spleen channel; But ascending YANG and invigorating QI, and " pearl sac " " the sweet Wen Chunyang of the Radix Astragali, it is with having five: mend all empty deficiencies, one also; Benefit vigour, two also; Strong taste, three also; Go flesh heat, four also; The hemopoietic of invigorating blood circulation.Modern pharmacological research is found: the Radix Astragali and effective ingredient astragaloside thereof and α-tyrosine have blood vessel dilating, reduce Peripheral resistance, thereby lightening heart load reduces myocardial oxygen consumption.The Radix Astragali can also improve the ability of myocardial cell anti-hypoxia " oxygen supply again " damage; Alleviate the damage of myocardial cells degree, keep the myocardial cell function of beating, improve myocardial cell energy metabolism protection cell ultrastructure; Improve SOD activity in the cell, strengthen the oxygen-derived free radicals ability of removing.Modern study is found: astragalin has positive inotropic action, has dose-effect relationship, and with Radix Astragali crude drug in calcium ion concentration irrelevant; And confirm that the astragalin IV is its effective ingredient, and it can make, and cAMP raises in the myocardial cell, activates the protein kinase of dependency ATP, makes the calciphorin phosphorylation, and flow of calcium ions increases; CAMP raises in the cell simultaneously, promotes the sarcoplasmic reticulum calcium ion to discharge, and strengthens thereby myocardial cell excitement-contraction Rhizoma Nelumbinis is joined.The Radix Astragali includes and multiple antibiotic effective ingredient, and the ability enhancing body's immunological function, therefore can also be used to prevent the generation of some infectious disease." book on Chinese herbal medicine meets former " carries: " Radix Astragali is can tonifying five ZANG-organs all empty, controls the stringy pulse spontaneous perspiration, rushes down YIN-fire, removes lung-heat, losslessly then sends out, and has antiperspirant then to end." be the good medicine of promoting resistance and defence disease.

Radix Salviae Miltiorrhizae is bitter, is slightly cold.GUIXIN, Liver Channel.Stasis-dispelling and pain-killing, promoting blood circulation to restore menstrual flow, relieving restlessness clears away heart-fire.Be used for menoxenia, the amenorrhea dysmenorrhea, lump in the abdomen, breast ventral spine pain, pyretic arthralgia pain, skin infection swells and ache, dysphoria and insomnia.Be used for the costa sternales hypochondriac pain, rheumatic arthralgia, lump in the abdomen caking, skin infection swells and ache, tumbling down is grieved, menoxenia, the amenorrhea dysmenorrhea, puerperal stasis of blood pain etc.Treatment costa sternales pain, lump in the abdomen caking, and menoxenia, amenorrhea dysmenorrhoea have good effect.The lid Radix Salviae Miltiorrhizae can break stagnated blood, mends fresh blood, peaceful tire, and the stillborn fetus that falls ends the metrorrhagia dysentery, the regulating menstruation arteries and veins.Its chemical constituent of Radix Salviae Miltiorrhizae mainly is divided into 2 types: one is fat-soluble TANSHINONES, and one is water solublity danshensu etc.No matter be clinical or the most scholars of experimentation have affirmed that Radix Salviae Miltiorrhizae has coronary artery dilator, improve myocardium anti-anoxia ability, the expansion peripheral blood vessel; Microcirculation improvement is regulated the reparation and the regeneration of tissue, activates fibrinolytic anticoagulant; Enhancing immunity, effect such as antibiotic grade.Especially it can improve myocardial contraction under the situation that does not influence oxygen consumption when core function badness, and decreased heart rate obviously improves cardiac function, and blood flow is quickened, and the capillary bed opening increases.

Flos Carthami is warm in nature, acrid in the mouth.Cure mainly the latus rectum of invigorating blood circulation, eliminating stasis to stop pain.Be used for that amenorrhea, dysmenorrhea, lochia are not all right, lump in the abdomen mass in the abdomen, traumatic injury." book on Chinese herbal medicine converges and says ": Flos Carthami, the medicine of removing blood stasis, promoting the circulation of blood and blood, accent blood also.Main tire produces all kinds of diseases and ailments and is trouble because of blood, or the tired bruise of blood, and coma in silence; Or lochia is robbed the heart, the umbilicus angina abdominis; Or the drop slurry is difficult living; Or afterbirth do not fall, and dead fetus in the uterus is all just before giving birth all cards, and non-Flos Carthami can not be controlled.If puerperal blood faints, locked mouth refer to hold in the hand; Or heresy goes into the blood chamber, and delirium is gone mad; Or vexed interior the expanding of blood, the sudden syncope with rigidity is that all puerperal, non-Flos Carthami can not be decided at card as extremely.All friendship like the obstructed and cold and heat of amenorrhea done, or expired stomachache and purple black dripping, or injury from falling down and the QI and blood stasis of blood is long-pending, or skin infection sufferings and swollen burst uneasyly, is cards of disharmony between QI and blood all, and non-Flos Carthami can not be transferred." medicineization justice ": Flos Carthami, kind tonneau passages through which vital energy circulates is gas medicine in the blood, can rush down and can mend, and wonderful justice is respectively arranged.If many with three, four money, then too hot temperature is wandered away blood.With Lignum Sappan removing blood stasis blood, to close Cortex Cinnamomi and stimulate the menstrual flow and close, assistant is returned, Chinese herbaceous peony is controlled all over or the pricking caused by the stagnation of QI and blood of breast abdomen, and this its row is led and is invigorated blood circulation also.If use seven, eight fens less, with dispersing liver-energy, helping the sea of blood, the void of enriching blood greatly, this its transfer smooth and with blood also; If end with two, three minutes, go into the heart to join painstaking effort, dismiss heart channel pathogenic fire, make the blood mediation, this its nourishing and hemopoietic are also; The justice of component number, meagre.Modern experiment shows that Flos Carthami has tangible effect to cardiovascular system: suppress the heart effect 1.: Flos Carthami decoct low dose can make Bufo siccus isolated heart and rabbit in slightly excitement of systemic heart, makes heart beating strong, and amplitude strengthens; Heavy dose then has inhibitory action to heart, makes decreased heart rate, and myocardial contraction weakens, and SV reduces.2. the experimentation to CF shows: Flos Carthami water extract and Flos Carthami water soluble mixt-Carthamus yellow have the effect of coronary blood flow increasing and myocardial nutrition property blood flow; The coronary artery dilating of Flos Carthami ethanol extraction and the effect of coronary blood flow increasing are then not obvious or do not have an influence.3. the experimentation to expeirmental myocardial ischemia and myocardial infarction shows: cause on the animal model of expeirmental myocardial ischemia or myocardial infarction rabbit, rat, dog etc., Flos Carthami and preparation thereof all have antagonism in various degree.Flos Carthami can make the rat or the rabbit acute myocardial ischemia that cause because of pituitrin that obvious protective effect is arranged; Can make repeatedly of short duration blocking-up coronary flow cause the degree of anesthetized dog acute myocardial ischemia obviously to alleviate; Scope is dwindled; Decreased heart rate; And the edge in protection acute myocardial infarction district, district and dwindle infarction size and reduce the amplitude that the marginal zone ECG ST section is raised, thus improve the supply-demand relationship of ischemic myocardium oxygen.Thereby Flos Carthami have the hemodynamics of improving myocardial ischemia reperfusion injury and reaches the effect that protection cardiac muscle improves function because of containing safflower yellow.Safflower yellow have the effect that obvious coronary blood flow increasing improves blood supply of cardiac muscle.In addition, safflower yellow has the obvious suppression effect to endogenous and extrinsic coagulation, but significant prolongation prothrombin time and clotting time, and to many links of coagulation process such as platelet adhesion reaction, thrombosis and fibrin are crosslinked etc. has inhibitory action.

The sweet mildly bitter flavor of Radix Notoginseng property, warm in nature, return liver, stomach through being used as medicine with root, root stock.Be rare Chinese medicine, but give birth to have good hemostasia effect, significant hemopoietic function with hemostasia and dissipation blood stasis, reducing swelling and alleviating pain; Can tighten and improve the arteria coronaria microcirculation, Radix Notoginseng is used as medicine with a long history, acts on peculiarly being regarded as the treasured in the medicine by ancient Chinese medicine doctor, so the saying of " Radix Stephaniae Sinicae (Radix Stephaniae Dielsianae) " is arranged." it is little sweet and bitter to distinguish the flavor of, quite seemingly the flavor of Radix Ginseng for Radix Notoginseng." " all canes are pounced on trauma, and the dripping person of blood stasis chews promptly ending of mashed net for catching birds or fish immediately, and bruise the person promptly dissipate.If when receiving cane, clothes one, two money earlier, then the blood centre of punch not should be obeyed it behind the cane especially, and obey also good puerperal.On the whole this medicine temperature, sweet and slightly bitter taste, and sun is bright, the medicine of the cloudy blood system of fainting, so can control all disorders of blood "." book on Chinese herbal medicine is looked for the truth " record: " Radix Notoginseng, common people only know the function hemostasis and pain-relieving.Hardly realize bitterly and ache work that blood ends because of applying the blood that looses because of blood stasis.The bitter temperature of Radix Notoginseng abnormal smells from the patient can be in its blood stasis of blood systemization." Radix Notoginseng ability coronary blood flow increasing, decreased heart rate reduces myocardial oxygen consumption, increases myocardium oxygen-resistant ability, and microcirculation improvement is removed the effect of smooth muscle spasm.

Radix Paeoniae Rubra is bitter, is slightly cold.Return Liver Channel.Function cures mainly clearing away heat and cooling blood, eliminating stasis to stop pain.Be used for maculae caused by violent heat pathogen, hematemesis and epistaxis, conjunctival congestion and swelling pain, hypochondriac pain due to stagnation of liverQI, amenorrhea dysmenorrhea, lump in the abdomen stomachache, injury from falling down, carbuncle skin infection.The Radix Paeoniae Rubra branch excess-heat that can purify the blood, dissipating blood stasis blood is detained.These article function and Cortex Moutan are close, so normal be usefulness with the Cortex Moutan mutual reinforcement between.But the effect of Cortex Moutan clearing away heat and cooling blood is preferable, and the branch excess-heat that can purify the blood can be controlled fever due to yin deficiency again; And Radix Paeoniae Rubra can only be used for the blood system excess-heat, is good at promoting blood circulation to remove blood stasis.

The Fructus Schisandrae Chinensis temperature; Sour, sweet; Return lung, the heart, kidney channel.Restrain astringent or styptic treatment for spontaneous sweating, supplementing QI for promoting the production of body fluid, kidney calming.Be used for the chronic cough dyspnea due to deficiency, emission, enuresis frequent micturition, incessant chronic diarrhea, spontaneous perspiration, night sweat, Tianjin wound is thirsty, the deficient pulse of losing heart, interior-heat is quenched one's thirst, palpitation and insomnia.Fruit is made Chinese medicine function supplementing QI for promoting the production of body fluid, the nourishing kidney of astringing the lung, antidiarrheal, arresting seminal emission, is calmed the nerves, and can control diseases such as chronic cough dyspnea due to deficiency, the few xerostomia in Tianjin, seminal emission chronic diarrhea, forgetful insomnia.The pharmacological testing proof can be regulated central nervous system's excitement and process of inhibition, promotes body metabolism, regulates the secretion of gastric juice and bile, and hepatitis convalescent period transaminase rising person is had the reduction effect.

Sweet, the mildly bitter flavor of property Radix Ophiopogonis is slightly cold.GUIXIN, lung, stomach warp.Function with cure mainly YIN nourishing and the production of body fluid promoting, lung moistening clears away heart-fire.Be used for dryness of the lung dry cough, the chronic consumptive disease cough, Tianjin wound is thirsty, vexed insomnia, interior-heat is quenched one's thirst, dryness of the intestine constipation, pharyngeal diphtheria.Control dryness of the lung dry cough, spit blood, spitting of blood, consumptive lung disease, lung abscess, the asthenia dysphoria with smothery sensation is quenched one's thirst, and hinder in calentura Tianjin, dry mouth and throat, constipation.These article are sweet cold clear and rich, the heat of the kind lung that clears away heart-fire and yin nourishing relieving restlessness, and holding concurrently can clear and rich gastrointestinal and quench the thirst and moisturize.Effect with anti-experimental character arrhythmia, increase coronary flow.

Rhizoma Atractylodis property is hot, bitter in the mouth, temperature.Return spleen, stomach, Liver Channel.Function cures mainly drying damp and strengthening spleen, and expelling wind and cold makes eye bright.Be used for distension and fullness in the abdomen, the edema of having loose bowels, beriberi flaccidity of feet with lamenness, rheumatic arthralgia, anemofrigid cold, nyctalopia.Influence to cardiovascular system shows that Rhizoma Atractylodis have slight inhibitory action to the Bufo siccus heart, and Bufo siccus hind leg blood vessel is had slight dilating effect.The low dose of intravenous injection of Rhizoma Atractylodis extractum can make rabbits blood pressure slightly rise, and heavy dose then makes blood pressure drops.The pharmacological action that the drying damp and strengthening spleen effect of Rhizoma Atractylodis is relevant is adjustment gastrointestinal motility function, antiulcer, protects the liver.Antibacterial etc.The main effective ingredient of Rhizoma Atractylodis is to be the volatile oil of representative with sagittol and hinesol.Rhizoma Atractylodis are to the influence of blood glucose, and anti-hypoxia, maincenter inhibition, antitumor, the calcification of promotion skeleton reach the effects such as influence to cardiovascular system, then are the modern study progress of its pharmacological action.

Rhizoma Chuanxiong is gone into liver, spleen, three warmers three warps.Function cures mainly activating QI to alleviate the depression, and the method wind-dryness is wet, promoting blood circulation and stopping pain.Control air-cooled headache and revolve dizzyly, the hypochondriac pain abdomen is painful, arthralgia due to cold clonic spasm of the muscle, amenorrhea, difficult labour, postpartum stagnation piece pain, ulcer sores.Be used for menoxenia, amenorrhea dysmenorrhea, abdominal mass stomachache, the twinge of the breast side of body, tumbling and swelling, headache, rheumatic arthralgia." detailed outline " carries: " dampness, antidiarrheal dysentery, activating QI to alleviate the depression." ligustrazine is removed vascular smooth muscle (aortic article) spasm (epinephrine, potassium chloride cause).Can also expand coronary vasodilator, coronary blood flow increasing.The myocardial ischemia-anoxemia that the antagonism pituitrin causes.Alleviate the myocardial infarction lesion degree that the ligation arteria coronaria causes.

Oletum Trogopterori is the dry feces of trogopterus xanthipes Milne-Edwards, can be used for the hemorrhage of blood-stasis internal-depression, escape of blood from meridian, and is many like the woman uterine bleeding warp, the purple polylith of color, stabbing pain of the lower abdomen.Both but single was fried and was ground into powder, and heat wine takes, and can be used with other drug again.Promoting blood circulation to remove blood stasis, the parch to black hemostasis.Be used for trusted subordinate's congestion and have a pain, dysmenorrhea, the blood stasis amenorrhea, puerperal abdominalgia with blood stasis; Parch to black is controlled metrostaxis; Traumatic injury is controlled in external, and Serpentis, insect bite are hindered.It is logical that the Oletum Trogopterori hardship is let out temperature, and " tonneau gaseous pulse ", " general rule is not bitterly." " the stasis passages through which vital energy circulates, gas must not be gone, and attacks cards such as thorn pain, must use in institute so " Bencao Jingshu " called it." when using, but single take, it is pained cruelly to control the soldier like " chicken peak Prescriptions for Universal Relief ", can not the person of bearing, use these article to be the end, under hot wine or the vinegar soup.If usefulness is controlled the pained and lochiostasis of stasis with the Pollen Typhae mutual reinforcement between, few abdomen is had a pain, and its benefit is clear, like " through the efficacious prescriptions " SHIXIAO SAN.If with the merit same usefulness of Rhizoma Corydalis, Myrrha and Rhizoma Cyperi of blood-activating and qi-promoting of holding concurrently, controlling stagnation of QI and blood, gastralgia such as thorn person, benefit increases the effect of blood stasis dispelling promoting the circulation of QI to relieve pain, picks up diffusing like " Medicine Comprehended " hands.Recently these article of Chang Youyong join invigorate blood circulation, circulation of qi promoting, the article that activate yang, the person that controls the angina pectoris also has good result.

Rhizoma Curcumae is hot, bitter, temperature.Return liver, spleen channel.The removing blood stasis promoting the circulation of QI to relieve pain: these article effect is with triangular similar, but warm concerted effort is bigger, can treat amenorrhea due to stagnation of blood stomachache, abdominal mass, gather.Long-pending eliminating stagnation: the pain relieving of these article ability circulation of qi promoting removing food stagnancy is used for eating accumulation, the breast abdominal distention is vexed has a pain.Removing blood stasis, women's amenorrhea, or the phlegm-damp congestion lump in the abdomen addiction piece that condenses and form.Promoting the circulation of QI to relieve pain: be suitable for drinking and eating irregularly, the card of gastral cavity abdomen overflow pain.Suitable compatibility, deficient syndrome, the case of a physically strong patient running a high fever all can.

Radix Polygalae is bitter, hot, tepor.GUIXIN, kidney, lung meridian.Function cures mainly the Fructus Alpiniae Oxyphyllae of calming the nerves, and eliminates the phlegm detumescence.Be used for the insomnia and dreamful sleep that disarmony between the heart and kidney causes, forgetful palpitation with fear, staring spells, expectoration is not well, sore swollen toxin, breast swell and pain.Be applied to insomnia and dreamful sleep, severe palpitation, forgetful.These article toil is warm in nature, property is kind lead off sensible, happily gas and mind tranquilizing and the heart calming, can lead to kidney qi and strong will is not forgotten, be restoring normal coordination between the heart and kidney, stable mind, the Fructus Alpiniae Oxyphyllae good merchantable brand of knowledge by force.Cure mainly the diseases such as malaise, insomnia, palpitation with fear of disarmony between the heart and kidney, normal and the same usefulness of medicinal for tranquilizing mind such as Poria cum Radix Pini, Dens Draconis, Cinnabaris are like Radix Polygalae ball (" the Zhang Shi doctor is led to "); Control forgetful card, normal and Radix Ginseng, Poria, the same usefulness of Rhizoma Acori Graminei are loose (" prescriptions worth thousand gold ") as happy, add Poria cum Radix Pini, promptly do not forget to loose (" Standards of Diagnosis and Treatment ") as if Fang Zhongzai." book on Chinese herbal medicine is just ": Radix Polygalae, the wholwe-hearted kidney of merit, so but the relieving palpitation spasmolytic, the peace that exorcises evil spirits dream, Yang strengthening and life essence tonifying, strong will power-assisted.With its gas lift, so same Radix Ginseng, Radix Glycyrrhizae, Semen Ziziphi Spinosae, the utmost point can be lifted and fall into consolidating semen, handing-over extreme misery.

Pheretima: Compendium of Material Medica is referred to as to have dredge the meridian passage, blood circulation promoting and blood stasis dispelling, the effect of prophylactic treatment cardiovascular and cerebrovascular disease.Pheretima salty in the mouth cold in nature.Function: heat clearing away, suppressing the hyperactive liver, Zhichuan, logical Lip river.It is fanatical dry to cure mainly height, convulsion with spasms, headache due to pathogenic wind-heat, conjunctival congestion, hemiplegia etc.Pheretima provides gets liquid the good effect that cloperastine is breathed heavily of deciding is arranged.

Retinervus Luffae Fructus: dredge the meridian passage is arranged, the effect of removing toxic substances and promoting subsidence of swelling.Cure mainly pain in chest and hypochondrium; Rheumatic arthralgia, passages through which vital energy circulates contracture, galactostasis, lung gesture cough, carbuncle future sore, his carbuncle." book on Chinese herbal medicine is just read ": Retinervus Luffae Fructus, go into meridians, separate pathogenic heat.Evanescence of heat then wind goes, and the unlikely combination of body fluid in the network and be expectorant becomes all diseases of toxic swelling, the ear so cloud detoxifies.

Radix Scutellariae has heat clearing and damp drying, and removing heat from blood is antiabortive, detoxicating functions.Cure mainly diseases such as epidemic febrile disease, upper respiratory tract infection, cough due to lung-heat, damp and hot jaundice, pneumonia, dysentery, hemoptysis, conjunctival congestion, frequent fetal movement, hypertension, carbuncle furuncle.The clinical practice of Radix Scutellariae is antibiotic not worse than Rhizoma Coptidis, and does not develop immunity to drugs.Hardship, cold.Return lung, gallbladder, spleen, large intestine, small intestine meridian.Heat clearing and damp drying, eliminating fire and detoxication, hemostasis, antiabortive, blood pressure lowering.Be used for hygropyrexia, fever disease in summer vomiting and nausea uncomfortable in chest, damp and hot feeling of fullness, dysentery, jaundice, the cough due to lung-heat, the hyperpyrexia excessive thirst, heat in blood is told nosebleed, carbuncle sore tumefacting virus, frequent fetal movement.

Radix Angelicae Sinensis: its sweet in the mouth and weighing, so specially can enrich blood, its gas is light and hot, thus again can promoting the circulation of blood, invigorating middle warmer has, in the row benefit is arranged, the gas medicine in the sincere blood, the also panacea in the blood.About mending of assistant to mend then, thus can support nutrition blood, the QI invigorating spermatogenesis, settling five organs, body by force, beneficial mind, all tangible deficient diseases, nothing is unsuitable.Assistant logical to attack then, so the relieving constipation bitterly of dispelling, relieving rigidity of muscles and joints is controlled contracture, paralysis, card such as dry, puckery.Nutrient QI being deficient and exterior syndrome being not relieved person, assistant is with agent such as bavin, Pueraria lobota, fiber crops, osmanthus, the Biao Weire that can loose greatly, and show not hold back the person, and help with Radix Et Rhizoma Rhei and so on, again can consolidating superficial resistance.Precisely because gas Xin Erdong, so desire its quiet person when keeping away it, the sliding benefaction of property is defecated and is not consolidated the person when keeping away it.All cloudy moderate heat Sheng persons, the active blood of Radix Angelicae Sinensis, also non-institute is suitable, cloudy deficiency of YANG of middle-JIAO person, Radix Angelicae Sinensis can nourish blood, and is indispensable.

Folium Isatidis is mainly used in pyretic toxicity and sends out diseases such as speckle, erysipelas, laryngopharynx swelling and pain, aphtha of the mouth and tongue, sore and toxic.This medicine extensive use is clinically in recent years controlled above-mentioned all diseases except that available, can be used for expectorant heat stagnation lung again, cough up phlegm yellow thick; Especially be usually used in popular second property encephalitis, but both single was applied to prevention, can cooperate Radix Bupleuri, Flos Lonicerae, Fructus Forsythiae, Radix Isatidis, Radix Scrophulariae, the Radix Rehmanniae etc. again, can removing summer-heat the pyretic toxicity that divides of edema caused by disorder of QI, battalion, availablely control various encephalitis b, and comparatively suitable with the partial heat type." detailed outline ": " main pyrotoxic dysentery, jaundice, sore throat, erysipelas." " LANYE juice is separated Mylabris, blue or green, the tree of heaven chicken of Yuan, Cinnabaris, arsenicum sablimatum poison." " book on Chinese herbal medicine is just ": " controlled the pestilence pyretic toxicity and goes mad, the wind heat macule, and carbuncle and ulcer swells and ache, and relieving thirst and restlessness ends epistaxis, haematemesis, kills infantile malnutrition erosion, incised wound curare.All with the heat malicious person that holds concurrently, all should LANYE smash juice and use it.

Fructus Gardeniae is bitter, and is cold.GUIXIN, lung, tri-jiao channel.Be used for calentura heating, vexedly rather do not wait disease.Fructus Gardeniae is kind to expel the heat-evil and relieving restlessness in pathogenic fire purging.At the edema caused by disorder of QI disease initial stage of fever caused by exogenous pathogenic factors, see disease such as heating is arranged, uncomfortable in chest, vexed, available Fructus Gardeniae cooperates Semen Sojae Preparatum, with expelling pathogenic factors from the exterior expel the heat-evil, the relieving restlessness resolving depression.As belong to all excess-heat fire diseases and see diseases such as hyperpyrexia agitation, unconsciousness and delirium, available article are joined pathogenic fire purging such as Cortex Phellodendri and clear pathogen is warm.

Herba Menthae is one of Chinese conventional Chinese medicine.It is hot cold property sweating and heat resolving medicine, controls influenza, headache, conjunctival congestion, fever of the body, throat, dental bed disease such as swell and ache.But the place is with training the mind dysmenorrhoea, skin pruritus, erythra and eczema etc.All herbal medicine, suffering, cold.Return lung, Liver Channel; The wind heat of dispersing is arranged, clearing throat, rash detoxifcation; Dispersing the stagnated live-QI to relieve the stagnation of QI and effect such as antipruritic; Be applicable to that cold, fever, headache, laryngopharynx swelling and pain, lossless, wind-fire acute conjunctivitis, rubella, skin are itched, disease such as colic, dysentery and scrofula, external has slight analgesic effect, is used for neuralgia etc.

Ramulus Cinnamomi is hot, sweet, temperature.GUIXIN, lung, urinary bladder channel.Expelling cold and relieving exterior syndrome; Promoting the flow of QI-blood by warming the meridian; Activating YANG and prormoting functioning of QI.The diaphoresis expelling pathogenic factors from muscles, promoting the flow of QI-blood by warming the meridian, supporing yang activating QI, the flat gas that spins.Be used for anemofrigid cold, coldness and pain in the epigastrium, cold in blood amenorrhea, arthralgia, phlegm retention, edema, cardiopalmus, renal mass.1. antibacterial action: the Ramulus Cinnamomi ethanol extract can suppress escherichia coli, bacillus subtilis and staphylococcus aureus external, and valid density is 25mg/ml or following; Staphylococcus albus, dysentery bacterium, typhoid fever and paratyphoid fever bacillus, streptococcus pneumoniae, aerobacteria, Bacillus proteus, anthrax bacillus, Salmonella enteritidis, vibrio cholera etc. are also had 2. antivirus action of inhibitory action (flat board dig a hole method): cultivate with human embryo kidney (HEK) simple epithelium cell tissue of former generation, Ramulus Cinnamomi decoct (1: 20) has inhibitory action to the first type capital 68-l of section strain of influenza Asia and Orphan virus (ECHO11).On Embryo Gallus domesticus, influenza virus there is inhibitory action, better with 70% pure preserved material effect.

The Folium Bambusae slightly sweet flavor, gas is put down little cold, is used for the flourishing aphtha of the mouth and tongue that causes of heart-fire, oliguria and red.Clearing heat and relieving fidgetness, the calentura excessive thirst is controlled in the diuresis of promoting the production of body fluid, and is used for the not most scorching vexed erosion of the oral mucosa tongue boil of waste heat after the calentura." book on Chinese herbal medicine is just " cloud: the irritated sleeplessness of reducing the asthenic fever, end excessive thirst, born fluid, Li Xiaoshui separates sore throat, and the children's wind-heat infantile convulsion.

Radix Isatidis clearing away heat and cooling blood, antiviral antibacterial action clinically is obvious, and consumption is big, can be rated as Chinese patent medicine.Result of study shows that Radix Isatidis has the internal energy pyrogen effect that causes fervescence of significant removing body." classification medical herbs property " carries: " separate all malicious malignant boil, diffusing poison reduces internal heat." and cheap, toxic and side effects is little, is the good medicine of very popular heat-clearing and toxic substances removing.

Compendium of Material Medica is carried " Flos Lonicerae is good at removing toxic substances, so control carbuncle, toxic swelling, skin ulcer tinea ... ".Since ancient times, Flos Lonicerae is usually used in heat-clearing and toxic substances removing, the heating of treatment epidemic febrile disease, toxic-heat and blood stasis, diseases such as carbuncle and ulcer.Modern pharmacological research shows, that Flos Lonicerae has is antibacterial, antiviral, antiinflammatory, analgesic, regulate the effect traditional Chinese medical science such as immunity and think, Flos Lonicerae is cold in nature, sweet in the mouth, gas are put down, and has the effect of heat-clearing and toxic substances removing, can treat diseases such as pyretic toxicity abscess, carbuncle furuncle.And have the diffusing effect of a surname concurrently.The Flos Lonicerae antipyretic and antidote functions is quite strong, is article commonly used in the orthopaedic surgical operations, generally is used to have the sore and toxic of red and swollen heat pain,

Fructus Forsythiae is bitter, is slightly cold.Return lung, the heart, small intestine meridian.Function is a heat-clearing and toxic substances removing, dispersing swelling and dissipating binds.Be used for carbuncle, scrofula, acute mastitis, erysipelas, anemopyretic cold, epidemic febrile disease is from the beginning of, warm joining the army, the hyperpyrexia excessive thirst, coma is sent out speckle, the pyretic stranguria urine retention.The medicinal part of Fructus Forsythiae mainly is a fruit.Its shell, i.e. " sticking up " in " a kind of reed mentioned in ancient books sticks up detoxifying pills ".Contain forsythol, coumarin, oleanolic acid, Saponin, Citrin etc.Have effects such as heat clearing away, detoxifcation, eliminating stagnation evacuation of pus.Cure mainly warm, skin infection, scrofula, erysipelas, class's rash, influenza, be decocted in water for oral dose with fruit, or add in the prescription.Be usually used in anemopyretic cold.Nature,taste and action: Chinese medicine bitter in the mouth, cold nature.Heat-clearing and toxic substances removing, mass dissipating and swelling eliminating.The mongolian medicine bitter in the mouth, cool in nature." association's day " clearly, antidiarrheal.Cure mainly: Chinese medicine is controlled calentura from the beginning of, anemopyretic cold, and heating is vexed, laryngopharynx swelling and pain, macule, erysipelas, scrofula, carbuncle pyogenic infections from tumour or sore, acute nephritis, pyretic stranguria.The mongolian medicine subcutaneous ulcer of harnessing the Yellow River, intestinal twinge, " association day " disease, intestinal heat.The Sheng Nong's herbal classic ": main cold and heat, Mus flaccidity, scrofula, carbuncle, malignant boil, goiter, stagnation of pathogenic heat, diseases due to noxious agents produced by various parasites.

The manufacturing process of the present invention's honey refining pill is: with crude drug 1000g Radix Ophiopogonis, Radix Salviae Miltiorrhizae 1000g, Flos Carthami 1000g, Radix Paeoniae Rubra 1000g, Fructus Schisandrae Chinensis 1000g, Radix Astragali 1000g; Oletum Trogopterori 1000g, Rhizoma Atractylodis 1000g, Retinervus Luffae Fructus 1000g, Rhizoma Chuanxiong 1000g, Rhizoma Curcumae 1000g; Radix Scutellariae 1000g, Radix Polygalae 1000g, Radix Angelicae Sinensis 1000g, Radix Isatidis 1000g, Folium Isatidis 1000g; Flos Lonicerae 1000g, Fructus Forsythiae 1000g, Herba Menthae 1000g, Fructus Gardeniae 1000g, Radix Notoginseng 1000g; Pheretima 1000g is ground into coarse powder, further pulverizes again, crosses 100 orders～120 mesh sieves, and the fine powder amount that enable pass is sieved is reaching 30%, and the fine powder of collecting through sieve gets fine powder a; Can not drop into multi-function extractor through the coarse powder of 120 mesh sieves again and extract twice, and add 5-10 times of water gaging for the first time and decocted 1-2 hour, and add 4-8 times of water gaging for the second time and decocted 1-2 hour, merge decocting liquid twice, and cross and filter filtrating; Heating is concentrated into pasty state, puts into 80 ℃ of oven dry of baking oven postcooling, grinds to form fine powder b, with a, calls in Mel after b mixes and processes honey refining pill.

Capsule preparation method thereof of the present invention is: Radix Ophiopogonis 1200g, Radix Salviae Miltiorrhizae 1200g, Flos Carthami 1000g, Radix Paeoniae Rubra 1200g, Fructus Schisandrae Chinensis 1000g; Radix Astragali 1200g, Oletum Trogopterori 1000g, Rhizoma Atractylodis 1000g, Retinervus Luffae Fructus 1200g, Rhizoma Chuanxiong 1100g; Rhizoma Curcumae 1000g, Radix Scutellariae 1500g, Radix Polygalae 1000g, Radix Angelicae Sinensis 1000g, Radix Isatidis 1000g; Folium Isatidis 1000g, Flos Lonicerae 1200g, Fructus Forsythiae 1000g, Herba Menthae 1000g; Fructus Gardeniae 1000g, Radix Notoginseng 1000g, Pheretima 1000g get the crude drug crude drug and add water logging bubble 1-2 hour that 5-10 doubly measures, and extract 2 times; Heating extraction 1-2 hour, be concentrated into the extractum shape, become component 1; Again medicinal residues are added the 60-90% soak with ethanol 1-2 hour, extract twice, each 0.5-1 hour, merge extractive liquid; Filter, concentrate, the 80-160 order filters, the 6000-10000 rev/min of supernatant after centrifugal; Through the molecular weight that dams is the ultrafiltration post ultrafiltration of 5000-10000,1.38 extractum when ultrafiltrate concentrating under reduced pressure relative density is 80 ℃, heating and refluxing extraction 2 times, each 30 minutes～45 minutes; Extract active ingredient, the merging of extracted twice liquid is settled into the extractum shape, as component 2; Adding the ethanol thickening filtration is the extractum shape, is component 2; Component 2 extractum are pulverized mixing, and the adding dextrin is an amount of, puts into the hothouse drying, and hot stream temperature is 80 ℃-100 ℃, gets raw material medicated powder, incapsulates patent medicine.

The method for preparing of tablet of the present invention: Radix Ophiopogonis 1500g, Radix Salviae Miltiorrhizae 1200g, Flos Carthami 1000g, Radix Paeoniae Rubra 1500g, Fructus Schisandrae Chinensis 1500g, Radix Astragali 1500g; Oletum Trogopterori 1500g, Rhizoma Atractylodis 1500g, Retinervus Luffae Fructus 1500g, Rhizoma Chuanxiong 1500g, Rhizoma Curcumae 1500g, Radix Scutellariae 1500g; Radix Polygalae 1000g, Radix Angelicae Sinensis 1500g, Radix Isatidis 1100g, Folium Isatidis 1100g, Flos Lonicerae 1100g, Fructus Forsythiae 1100g; Herba Menthae 1500g, Fructus Gardeniae 1500g, Radix Notoginseng 1500g, Pheretima 1500g add 10 times of amount ethanol, heating and refluxing extraction 3 times; Each 2 hours, 3 extracting solution are merged, decompression recycling ethanol and to be concentrated into liquor strength be 0.5g crude drug/mL, behind the sucking filtration, the relative density of filtrating is about 1.08 (20 ℃); Above-mentioned filtrating is the macroporous adsorptive resins of 10L through volume, and with the deionized water or the distilled water eluting of 10 times of resin column volumes, 95% ethanol elution of 5 times of resin column volumes of reuse is collected ethanol elution, removes solvent, obtains the component medicine earlier; Be pressed into tablet with amylodextrin.

The method for preparing of drop pill of the present invention may further comprise the steps: according to said component ratio of weight and number with Pheretima 1200g; Rhizoma Curcumae 1200g, Rhizoma Chuanxiong 1500g and Radix Notoginseng 1200g are with adding the water that 5-7 doubly measures; Put into multi-function extractor; Keep air pressure at 0.04-0.06mPa, decocted 2 hours, extract its water soluble ingredient; Repeat above-mentioned steps and extracted extracting liquid filtering 100 mesh sieves once more 1.5 hours; With the refining filtrating of macroporous adsorbent resin, use ethanol elution; It is 1.33-1.35 that eluent is evaporated to density, and wherein input air pressure is 0.04-0.06mPa, and vacuum is-0.076-0.088mPa stand for standby use; All the other component 1500g Radix Ophiopogonis, Radix Salviae Miltiorrhizae 1500g, Flos Carthami 1500g, Radix Paeoniae Rubra 1500g, Fructus Schisandrae Chinensis 1500g; Radix Astragali 1200g, Oletum Trogopterori 1500g, Rhizoma Atractylodis 1500g, Retinervus Luffae Fructus 1500g, Radix Scutellariae 1300g; Radix Polygalae 1500g, Radix Angelicae Sinensis 1300g, Radix Isatidis 1500g, Folium Isatidis 1300g, Flos Lonicerae 1500g; Fructus Forsythiae 1500g, Herba Menthae 1300g, Fructus Gardeniae 1500g adds the water that its weight sum 5-7 doubly measures; Put into multi-function extractor, maintenance air pressure is 0.04-0.06mPa, decocts 2 hours; The filter extracting solution is crossed 100 mesh sieves; Vacuum concentrated filtrate is to crude drug amount 1: 1W/V; Concentrated solution adds ethanol precipitation; Ethanol precipitation liquid filters with 100 mesh sieves; The use sephadex chromatography is refining, uses ethanol elution; Eluent is concentrated into density 1.33-1.35, leaves standstill; Get above-mentioned two kinds leave standstill drop go into cool off in the dimethicone drop pill.

Drop pill machine technology parameter is following: the drip irrigation temperature keeps 85-95 ℃, and condensed fluid liquid paraffin temperature is lower than 8 ℃, and the water dropper internal diameter is 1.6mm, and the water dropper external diameter is 2.5mm, and water dropper is 15cm apart from the liquid paraffin surface distance; Centrifugal, rotating speed 800-1100rpm after 15 minutes, removes deparaffnize and gets final product.Be quick acting, drop pill of the present invention is made into to dissolve the piller of absorption in the Sublingual rapidly, and it can go into blood fast, through cardiac muscle.Toxicology test:

Experimental example 1: acute toxicity test of the present invention

One, test material:

Animal: Kunming mouse, body weight 21-24g, male and female half and half, the biology laboratory breeding of magnificent section.Medicine: tablet of the present invention contains 0.0425g crude drug/sheet.

Two, method:

1, LD50 calculates: adopt the improvement karber's method, mice is divided into 5 groups at random, and 10 every group, male and female half and half; With the dissolving of tablet adding distil water, be made into Cmax, by the administration of the maximum permission capacity of mice, institute is followed successively by 18 to dosage by the crude drug amount; 14.4,11.5,9.2,7.4 (g.kg-1); In animal fasting (can't help water) after 18 hours, administration at twice (half an hour at interval) in a day, each 0.5ml observes the animal dead situation.

2, maximum tolerated dose is measured (MTD value): get 20 of mices, each 10 of male and female.With tablet adding distil water dissolving, be made into maximum concentration, by the maximum tolerated dose of animal, irritate with injection and to feed device and can twitch and be as the criterion.In animal fasting (can't help water) after 18 hours, administration at twice (half an hour at interval) in a day, each 0.5ml (every ml contains crude drug 0.36g), total dose is 18g crude drug/kg.d, 300 times of quite clinical adult 50Kg body weight consumption.Observed 7 days continuously after the administration.

Three, result of the test:

In LD50 calculates when giving mice (18g/Kg.d) with maximum acceptable concentration and maximum permission capacity; Do not see dead mouse, promptly do not measure LD50, ask maximum tolerated dose only; In 7 day observation period; Its appetite of animal, activity, hair color, the mental status etc. are all normal, grow normally, and not seeing has death.Promptly select 300 times of doses that are equivalent to clinical dosage for use, and have no adverse reaction, show that acute toxicity is minimum, MTD＞18g/Kg.d.

Experimental example 2: the result of the test of acute toxicity and long term toxicity

Acute toxicity test: give drop pill of the present invention through the disposable filling stomach of white mice; Maximum concentration 35%, maximum gastric capacity 0.4ml/10g, the dosage 14g/kg (every g medicated powder is equivalent to the 10g crude drug) of irritating; Observed 7 days continuously; Do not find any toxic reaction, because of concentration and dosage can't increase, so fail to measure the LD 50 of this medicine.Maximum tolerance determination: with maximum concentration, the maximum gastric capacity of irritating, mice lavage administration 3 times, 5 hours at interval, to observe continuously then 7 days, none example is dead.Medicated powder dosage is＞42g/kg. day (every g medicated powder is equivalent to the 10g crude drug), calculate the clinical consumption per day that is equivalent to be grown up by kg body weight 420 times.Long term toxicity test: for observing whether toxigenicity reaction of long-term prescription, give these article of rat medicated powder respectively and raise clothes, by 70 times of the clinical consumption per day of being grown up and 35 times (being 7g/kg/ day and 3.5g/kg/ day); In 8 weeks of successive administration, do not see that behavior, feed, the body weight of rat occurs unusually, with the matched group ratio; Routine blood test, hepatic and renal function, all no abnormal change of various important organs; In institute's dosage scope, do not found any toxicity of these article.Acute and chronic toxicity test through animal confirms that these article drug safety scope is bigger, is a kind of safe and reliable compound preparation.

Experimental example 3: aggregate toxicity experiment:

The agent of Chinese medicine preparation of the present invention honey refining for oral administration pill to mice by 7.69,19.18 and the 43.21g crude drug/15 weeks of kg continuous use (1.0ml/100g body weight; Every day 2 times) and after 3 week of drug withdrawal; The result shows: Chinese medicine preparation of the present invention does not all have obvious influence to indexs such as the hair of rat, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat; The internal organs naked eyes do not find that difference changes and the histological examination result shows; After 15 weeks of medication and 3 weeks of drug withdrawal, each internal organs of rat all do not have obvious change.Explain that toxicity is little after Chinese medicine preparation oral capsule of the present invention is to the rat long-term prescription, also do not have the difference reaction after the drug withdrawal, application safety.

Experimental example 4: external anti-CB 3 viral result of the tests show: drop pill of the present invention has the significant protection effect to rat neonatal rat myocardial cell and the Vero cell that infects CB 3 viruses; Can stop CB 3 viral absorption surfaces, get into cell and produce direct deactivation.The medication group can obviously reduce the lesion degree of cultured cell, reduces the myocardial cell virus titer that infects, and is good dose-effect relationship.

Experimental example 5: anti-CB 3 viral result of the tests show in the body: drop pill of the present invention has the significant protection effect to CB 3 virogenetic mice viral myocarditis; Can improve neutralizing antibody concentration in the mice body; Obviously suppress Vero necrocytosis rate; It suppresses percentage rate can reach 400%, and obviously reduces administration group mice serum virus titer.Pathological examination shows that the pathological change of administration group mouse cardiac muscle cell is significantly less than the virus control group, and prompting has therapeutical effect to viral myocarditis.

Therefore; Can think that from results of pharmacodynamic test these article have anti-CB 3 viruses; Protecting myocardial cell increases the blood supply oxygen supply of cardiac muscle, improves myocardial ischemia and antiarrhythmic effect; Be the medicine that a comparatively ideal treatment pyretic toxicity is invaded heart type viral myocarditis, the result of clinical trial has also further proved its curative effect.

Pharmacological experiment:

Experiment 1: the effect of white mice normal pressure hypoxia-bearing capability

Experimental technique and result: get 50 of ICR white mice; Be divided into 5 groups at random; Every group 10; Male and female half and half, that is: blank group, Chinese medicine preparation of the present invention (drop pill) high dose group (1.8g/kg), middle dose groups (0.9g/kg), low dose group (0.45g/kg), inosine sheet matched group (2g/kg).Each treatment group by above-mentioned dosage respectively decocte with water be condensed into medicinal liquid, the administration capacity is 0.3ml/10g, gastric infusion, the blank group give to wait the normal saline of capacity to irritate stomach, once a day, continuous 14 days.After the last administration 1 hour, white mice is put into the tool plug ground glass stoppered bottle of 250ml dress sodica calx, sealing is observed and is respectively organized every mouse diing time, and the result sees table 1.

The influence of table 1 pair mice anoxia enduring

Conclusion: drop pill of the present invention has the effect that improves white mice normal pressure hypoxia-bearing capability.

Experiment 2: to the influence of mice viral myocarditis

(1) test material

Animal: the Swiss mice, male and female half and half, in age in 3-4 week, 16-18g is provided by Shandong University's medical board Experimental Animal Center.

Medicine: stem and leaf of Radix Panacis Quinquefolii total saponins, positive control drug are drop pill of the present invention.

(2) test method and result

Inoculation contains 10 4 TCID, 50 CVB, 3 liquid 0.2ml through the abdominal cavity with mice, behind the 1h, and gastric infusion, two weeks of successive administration.The virus of model control group mouse inoculation same dose irritates stomach, continuous two weeks for every day the normal saline of same dose.After the last administration, pluck eyeball and get blood, separation of serum is measured myocardium three enzyme glutamic oxaloacetic transaminase, GOT AST, creatine phosphokinase CK, lactate dehydrogenase L DH.The result sees table 2.

The influence of table 2 pair mice viral myocarditis cardiac muscle three enzymes (X ± s)

Annotate: with the virus control group than * p＜0.05, * * p＜0.01

The result shows that drop pill of the present invention can significantly reduce myocardium three enzymes in the myocarditis animal pattern blood, has the effect of treatment viral myocarditis.

Clinical experiment:

Year April in March, 2007 to 2010 in Jinan institute of traditional Chinese medicine screening patient 122 examples.

1 data and method

Matched group 62 examples, routine adds 5% glucose injection, 250 ml with virazole 0. 5 g, quiet of day 1 time; Quiet of Energy mixture (10% glucose injection, 250 ml+coenzyme A 100 u+ATP injection 40 μ g+ vitamin Cs 5. 0 g) day 1 time.The ARR arrhythmia that gives occurring disposes to the ill.4 weeks were 1 course of treatment.

Treatment group patient 60 examples, basic prescription: Radix Ophiopogonis 10g, Radix Salviae Miltiorrhizae 10g, Flos Carthami 15g, Radix Paeoniae Rubra 10g, Fructus Schisandrae Chinensis 15g, Radix Astragali 10g, Oletum Trogopterori 10g; Rhizoma Atractylodis 15g, Retinervus Luffae Fructus 10g, Rhizoma Chuanxiong 10g, Rhizoma Curcumae 10g, Radix Scutellariae 15g, Radix Polygalae 10g, Radix Angelicae Sinensis 10g, Radix Isatidis 10g; Folium Isatidis 15g, Flos Lonicerae 10g, Fructus Forsythiae 15g, Herba Menthae 10g, Fructus Gardeniae 10g, Radix Notoginseng 10g, determination of treatment based on pathogenesis obtained through differentiation of symptoms and signs on the basis of Pheretima 15g, specific as follows: palpitation and restlessness; Uncomfortable in chestly do not relax, do when pained, or see cyanosis of the lips and nails, purplish tongue or ecchymosis is arranged, hesitant pulse or knot generation, so with blood circulation promoting and blood stasis dispelling, regulating qi and dredging collateral; Disease is seen pharyngalgia, fever and cough, sensation of oppression over the chest with shortness of breath, cardiopalmus is vexed, red tip of the tongue, yellow and thin fur, thready and rapid pulse or the knot generation.Be decocted in water for oral dose 21 dose of every day, and 4 weeks were 1 course of treatment.The concurrent infection person adds and uses antibiotic.　

Clinical recovery: clinical symptoms, sign disappear, and electrocardiogram, X line rabat, ultrasoundcardiogram, myocardial enzymes inspection recover normal; Take a turn for the better: clinical symptoms, sign turn for the better by and large, and electrocardiogram takes a turn for the better, and X line chest film inspection heart shadow (X dwindles, the basic normal or chamber wall thickness increase of echocardiography, and the myocardial enzymes inspection is normal; Invalid: clinical symptoms, sign, electrocardiogram, X line rabat, ultrasoundcardiogram, myocardial enzymes inspection all do not have and are clearly better.

2 results

After the course of treatment, treatment group patient clinical cure 38 examples, effective 20 examples, invalid 2 examples, total effective rate is 97%; Matched group patient clinical cure 20 examples, effective 11 examples, invalid 31 examples, total effective rate is 50%.Two groups have significant difference (P>0. 05) on clinical cure rate and total effective rate.See table 1.

Symptom, sign (x ± s) relatively before and after the treatment of table 1 liang group

3 discuss

Differential diagnosis in tcm is executed and is controlled, and giving consideration to both the incidental and fundamental has opened up new approaches for the treatment of viral myocarditis, has obtained good result through clinical observation.Result of study demonstration Chinese medicine therapy can fundamentally be adjusted myocarditis patient body complex immunological state, can obviously reduce too high Immunoglobulin IgA, IgG, eliminates antimyocardial antibody, free radical; Through clearing away phlegm, collateral dredging, removing blood stasis with potent drugs; Can suppress to decompose the myocardial fibrosis tissue, and have and obviously prevent myocardial remodelling, prevent that myocarditis is converted into the dilated cardiomyopathy effect; Anti-recurrence is worth clinical application.

Specific embodiment 1: Zheng, the male, 16 years old, patient's week of flu in 2008, disease was seen pharyngalgia, fever and cough, sensation of oppression over the chest with shortness of breath; Cardiopalmus is vexed, red tip of the tongue, yellow and thin fur, thready and rapid pulse or knot add the generation, belong to pyretic toxicity and invade heart type: medicinal Radix Ophiopogonis 10g, Radix Salviae Miltiorrhizae 10g, Flos Carthami 15g; Radix Paeoniae Rubra 10g, Fructus Schisandrae Chinensis 15g, Radix Astragali 10g, Oletum Trogopterori 10g, Rhizoma Atractylodis 15g, Retinervus Luffae Fructus 10g, Rhizoma Chuanxiong 10g; Rhizoma Curcumae 10g, Radix Scutellariae 15g, Radix Polygalae 10g, Radix Angelicae Sinensis 10g, Radix Isatidis 10g, Folium Isatidis 15g, Flos Lonicerae 10g; Fructus Forsythiae 15g, Herba Menthae 10g, Fructus Gardeniae 10g, Radix Notoginseng 10g, Pheretima 15g processes pill, adds 5% glucose injection, 250 ml with virazole 0. 5 g simultaneously, quiet of day 1 time; Quiet of Energy mixture (10% glucose injection, 250 ml+coenzyme A 100 u+ATP injection 40 μ g+ vitamin Cs 5. 0 g) day 1 time.The ARR arrhythmia that gives occurring disposes to the ill.Add the treatment of heartbeat health, patient symptom is clearly better after 30 days, and electrocardiogram S-T section often changes correction after treating 4 months, and cardiac ultrasonic shows that left chamber contractile function is normal, continues to take consolidation in 50 days, recurrence so far after the drug withdrawal.

Specific embodiment 2: poplar, the woman, 21 years old, bad from little body constitution, catch cold easily, cat fever in 2007 causes pharyngalgia, fever and cough, sensation of oppression over the chest with shortness of breath; Cardiopalmus is vexed, and disease is seen severe palpitation, the throat enlargement, yellowish urine, red tip of the tongue, yellow and thin fur, spiritlessness and weakness, spontaneous perspiration or night sweat, thready and rapid pulse or knot substitute: belong to pyretic toxicity and invade heart type: medicinal Radix Ophiopogonis 10g; Radix Salviae Miltiorrhizae 15g, Flos Carthami 10g, Radix Paeoniae Rubra 10g, Fructus Schisandrae Chinensis 10g, Radix Astragali 10g, Oletum Trogopterori 10g, Rhizoma Atractylodis 15g, Retinervus Luffae Fructus 10g; Rhizoma Chuanxiong 10g, Rhizoma Curcumae 15g, Radix Scutellariae 15g, Radix Polygalae 10g, Radix Angelicae Sinensis 10g, Radix Isatidis 10g, Folium Isatidis 15g; Flos Lonicerae 10g, Fructus Forsythiae 15g, Herba Menthae 10g, Fructus Gardeniae 15g, Radix Notoginseng 10g, Pheretima 10g processes honey refining pill.Control with supplementing QI and nourishing YIN, nourishing yin and promoting blood circulation, be equipped with 10 % glucose injections, 250 mL and add SHENGMAI ZHUSHEYE 30 mL intravenous drips, 1 time on the 1st.Nursing is the basis with psychology and living nursing, treatment by Chinese herbs and traditional Chinese medical science holistic Nursing through 3 months, and transference cure, electrocardiogram recover normal, recovered and discharged.

Specific embodiment 3: Qiu, the man, 28 years old, irritability was liked to get angry at ordinary times, and flu is got angry a few days; Liver-fire expectorant heat is done when disease is seen cardiopalmus, and is vexed uncomfortable in chest, insomnia and dreamful sleep, bitter taste in the mouth and dry throat; Constipation, yellowish or reddish urine, red tongue, yellow and greasy fur, stringy and rolling pulse or short; Auxiliary examination: numeration of leukocyte raises, electrocardiographic abnormality, and myocardial damage ST-T changes, and the ventricular premature contraction symptom is arranged, and is diagnosed as viral myocarditis after the diagnosis.The patient is cut out Western medicine, change Chinese traditional treatment, the side uses: Radix Ophiopogonis 15g, Radix Salviae Miltiorrhizae 15g, Flos Carthami 10g, Radix Paeoniae Rubra 10g; Fructus Schisandrae Chinensis 10g, Radix Astragali 10g, Oletum Trogopterori 10g, Rhizoma Atractylodis 15g, Retinervus Luffae Fructus 10g, Rhizoma Chuanxiong 10g; Rhizoma Curcumae 15g, Radix Scutellariae 15g, Radix Polygalae 10g, Radix Angelicae Sinensis 10g, Radix Isatidis 15g, Folium Isatidis 10g; Flos Lonicerae 15g, Fructus Forsythiae 15g, Herba Menthae 10g, Fructus Gardeniae 15g, Radix Notoginseng 10g, Pheretima 10g; Take the medicine pill according to the present invention, take every day three times, each 3 balls gave conventional to lie up when the viral myocarditis acute attack, oxygen uptake, Energy mixture, through one month treatment; The state of an illness is stablized with becoming, but slight cardiac dilatation is arranged, aroused in interestly can go down, arrhythmia or electrocardiogram change, through 6 months treatment, any Sx was not left in patient's recovery from illness.

Claims (10)

1. treat the Chinese medicine preparation that pyretic toxicity is invaded heart type viral myocarditis for one kind, it is characterized in that, the ratio of weight and number of various crude drug is in the said Chinese medicine preparation: 10～20 parts of Radix Ophiopogonis, 10～20 parts of Radix Salviae Miltiorrhizaes, 10～20 parts on Flos Carthami; 10～20 parts of Radix Paeoniae Rubra, 10～20 parts of Fructus Schisandrae Chinensis, 10～20 parts of Radix Notoginseng, 10～20 parts of the Radixs Astragali, 10～20 parts of Oletum Trogopteroris; 10～20 parts of Rhizoma Atractylodis, 10～20 parts of Retinervus Luffae Fructuss, 10～20 parts of Rhizoma Chuanxiongs, 10～20 parts of Rhizoma Curcumae, 10～20 parts of Radix Scutellariaes; 10～20 parts of Radix Polygalaes, 10～20 parts of Pheretimas, 10～20 parts of Radix Angelicae Sinensis, 10～20 parts of Radix Isatidis, 10～20 parts of Folium Isatidiss; 10～20 parts of Flos Loniceraes, 10～20 parts of Fructus Forsythiaes, 10～20 parts of Herba Menthaes, 10～20 parts of Fructus Gardeniaes.

2. invade the Chinese medicine preparation of heart type viral myocarditis according to the said treatment pyretic toxicity of claim 1, it is characterized in that the ratio of weight and number of various crude drug is in the said Chinese medicine preparation: 10～15 parts of Radix Ophiopogonis, 10～15 parts of Radix Salviae Miltiorrhizaes; 10～15 parts on Flos Carthami, 10～15 parts of Radix Paeoniae Rubra, 10～15 parts of Fructus Schisandrae Chinensis, 10～15 parts of Radix Notoginseng; 10～15 parts of the Radixs Astragali, 10～15 parts of Oletum Trogopteroris, 10～15 parts of Rhizoma Atractylodis, 10～15 parts of Retinervus Luffae Fructuss; 10～15 parts of Rhizoma Chuanxiongs, 10～20 parts of Rhizoma Curcumae, 10～20 parts of Radix Scutellariaes, 10～20 parts of Radix Polygalaes; 10～20 parts of Pheretimas, 10～20 parts of Radix Angelicae Sinensis, 10～20 parts of Radix Isatidis, 10～20 parts of Folium Isatidiss; 10～20 parts of Flos Loniceraes, 10～20 parts of Fructus Forsythiaes, 10～20 parts of Herba Menthaes, 10～20 parts of Fructus Gardeniaes.

3. invade the Chinese medicine preparation of heart type viral myocarditis according to the said treatment pyretic toxicity of claim 1, it is characterized in that the ratio of weight and number of various crude drug is in the said Chinese medicine preparation: 10～20 parts of Radix Ophiopogonis, 10～20 parts of Radix Salviae Miltiorrhizaes; 10～20 parts on Flos Carthami, 10～20 parts of Radix Paeoniae Rubra, 10～20 parts of Fructus Schisandrae Chinensis, 10～20 parts of Radix Notoginseng; 10～20 parts of the Radixs Astragali, 10～20 parts of Oletum Trogopteroris, 10～20 parts of Rhizoma Atractylodis, 10～20 parts of Retinervus Luffae Fructuss; 10～20 parts of Rhizoma Chuanxiongs, 10～15 parts of Rhizoma Curcumae, 10～15 parts of Radix Scutellariaes, 10～15 parts of Radix Polygalaes; 10～15 parts of Pheretimas, 10～15 parts of Radix Angelicae Sinensis, 10～15 parts of Radix Isatidis, 10～15 parts of Folium Isatidiss; 10～15 parts of Flos Loniceraes, 10～15 parts of Fructus Forsythiaes, 10～15 parts of Herba Menthaes, 10～15 parts of Fructus Gardeniaes.

4. invade the Chinese medicine preparation of heart type viral myocarditis according to each said treatment pyretic toxicity in the claim 1～3; It is characterized in that the dosage form of said Chinese medicine preparation is a honey refining pill, its preparation method comprises: earlier said crude drug is ground into coarse powder; Further pulverize again; Cross 100 orders～120 mesh sieves, the fine powder amount that enable pass is sieved is reaching 20 ~ 30%, and the fine powder of collecting through sieve gets fine powder a; Can not drop into multi-function extractor through the coarse powder of 100 ~ 120 mesh sieves again and extract twice, and add 5-10 times of water gaging for the first time and decocted 1-2 hour, and add 5-10 for the second time and doubly measured ethanol extraction 1-2 hour, merge decocting liquid twice, and cross and filter filtrating; Heating is concentrated into pasty state, puts into 80 ℃ of oven dry of baking oven postcooling, grinds to form fine powder b, with fine powder a, calls in Mel after b mixes and processes honey refining pill.

5. invade the method for preparing of the Chinese medicine preparation of heart type viral myocarditis like each said treatment pyretic toxicity in the claim 1～3 for one kind, it is characterized in that its dosage form is a capsule, its preparation method comprises:

A, get crude drug and add water extraction 2 times, become the extractum shape, be component 1;

It is the extractum shape that b, medicinal residues add the ethanol thickening filtration, is component 2;

C, two kinds of component extractum are mixed pulverize, add dextrin, mixing, fill capsule.

6. according to the said method for preparing of claim 5, it is characterized in that, among the said step a, get crude drug and add water logging bubble 1-2 hour that weight portion 5-10 doubly measures, extract 2 times; Heating extraction 1-2 hour, be concentrated into the extractum shape, become component 1.

7. according to the said method for preparing of claim 5, it is characterized in that among the said step b, medicinal residues added the 60-90% soak with ethanol 1-2 hour; Extract twice, each 0.5-1 hour, merge extractive liquid, filtered; Concentrate, the 80-160 order filters, and the 6000-10000 rev/min of supernatant after centrifugal is the ultrafiltration post ultrafiltration of 5000-10000 through the molecular weight that dams; 1.38 extractum when ultrafiltrate concentrating under reduced pressure relative density is 80 ℃, heating and refluxing extraction 2 times, each 30 minutes～45 minutes; Extract active ingredient, the merging of extracted twice liquid is settled into the extractum shape, as component 2.

8. according to the said method for preparing of claim 5, it is characterized in that, among the said step c, two kinds of component extractum are pulverized mixing, add dextrin, put into the hothouse drying, hot stream temperature is 80 ℃-100 ℃, gets raw material medicated powder, incapsulates patent medicine.

9. method for preparing of invading the Chinese medicine preparation of heart type viral myocarditis like each said treatment pyretic toxicity in the claim 1～3; It is characterized in that the dosage form of said medicine is a drop pill, its concrete steps comprise: according to said component ratio of weight and number with Pheretima; Rhizoma Curcumae, Rhizoma Chuanxiong and Radix Notoginseng add the water that its parts by weight sum 5-7 doubly measures; Put into multi-function extractor, keep air pressure to decoct 2 hours, extract its water soluble ingredient at 0.04-0.06mPa; Extracting liquid filtering 100 mesh sieves; With the refining filtrating of adsorbent resin back ethanol elution; Eluent is evaporated to density 1.33-1.35, and wherein input air pressure is 0.04-0.06mPa, and vacuum is-0.076 ~-0.088 mPa, stand for standby use; All the other components add the water that its parts by weight sum 5-7 doubly measures; Put into multi-function extractor, maintenance air pressure is 0.04-0.06mPa, decocts 2 hours; The filter extracting solution is crossed 100 mesh sieves; Vacuum concentrated filtrate is to crude drug amount 1: 1W/V; Concentrated solution adds ethanol precipitation; Ethanol precipitation liquid filters with 100 mesh sieves; The use sephadex chromatography is refining, uses ethanol elution; Eluent is concentrated into density 1.33-1.35, leaves standstill; Get above-mentioned two kinds leave standstill drop go into cool off in the dimethicone drop pill.

10. invade the Chinese medicine preparation of heart type viral myocarditis according to each said treatment pyretic toxicity in the claim 1～3; It is characterized in that its dosage form is: tablet, sugar coated tablet, film coated tablet, enteric coated tablet, capsule, hard capsule, soft capsule, oral liquid, suck agent, granule, electuary, honey pill agent, powder, sublimed preparation, solution, injection, suppository, plaster, syrup, drop pill or extractum.