CN102759474A - Liquid-based cell smear manufacturing and dyeing machine utilizing principles of injection and pipetting - Google Patents
Liquid-based cell smear manufacturing and dyeing machine utilizing principles of injection and pipetting Download PDFInfo
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- CN102759474A CN102759474A CN2012101942010A CN201210194201A CN102759474A CN 102759474 A CN102759474 A CN 102759474A CN 2012101942010 A CN2012101942010 A CN 2012101942010A CN 201210194201 A CN201210194201 A CN 201210194201A CN 102759474 A CN102759474 A CN 102759474A
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- 238000004519 manufacturing process Methods 0.000 title description 3
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- 210000000270 basal cell Anatomy 0.000 claims description 24
- 210000004027 cell Anatomy 0.000 claims description 21
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Abstract
The invention relates to a liquid-based cell smear manufacturing and dyeing machine utilizing principles of injection and pipetting, which is characterized by structurally comprising a machine base, a machine body, a worktable, a horizontal slide rail, a moving arm, a horizontal motor moving device, an up-down motor moving device and a microcomputer motion control system, wherein four groups of smear manufacturing and dyeing units and a kit are mounted on the worktable board; and 24 samples can be automatically manufactured into smears and dyed when the machine runs once. The liquid-based cell smear manufacturing and dyeing machine does not need a tedious specific gravity liquid gradient centrifugation step, a micropipe type liquid drawing system of a liquid-based cytology test (LCT) machine, or processes of vacuum negative pressure drawing and positive pressure cell transfer of a microporous filter membrane of a Thinprep cytology test (TCT) machine. Cell samples are drawn, evenly mixed and scattered by using a pipetting injector and sample reagents are transferred by utilizing an accurate quantitative liquid drawing and injecting function of the pipetting injector. Cells in a settling and smear-manufacturing bin are naturally settled on a sticky glass slide by relying on the gravity of the cells and then automatically dyed. The liquid-based cell smear manufacturing and dyeing machine has the advantages that the operation is simple, the cost is relatively low, and high quality liquid-based cytological smears can be rapidly manufactured.
Description
Technical field
The present invention relates to a kind ofly use injection to move the liquid basal cell film-making overflow dyeing machine of liquid principle; Specifically a kind of simple efficient, film-making high-quality and high liquid based cytology film-making and the dyeing integration instrument and equipment of automaticity are applied in clinical medicine pathology, cytology check and biological study field.
Background technology
The traditional-handwork smear technique has almost been continued to use last 100 years unalterablely.The eighties is noticed the two big reasons that mainly contain of false negative case in the self-examination to the traditional-handwork smear technique.At first be to have cell more than 80% still to remain on the sampler in the smear process and thrown away; Next is the smear poor quality, and the abnormal cell on the microslide possibly overlap each other or covered and be difficult to discern by inflammatory cell, red blood cell; Smear also possibly diagnosed because of factor affecting such as fixing untimely, cell dryings.Problem to the existence of traditional-handwork smear; Be accompanied by the high speed development of computer information technology and automated control technology; From the later stage 1980s; Sample collection and tabletting technology that people's pair cell is learned constantly improve, and a series of liquid based cytology film-makings are arisen at the historic moment with the dyeing new technology.At present, mainly be that following two quasi-instruments are representative on the market.
The automatic liquid basal cell pelleter of film pipe filtering type is commonly called as TCT.Its uses filtering membrane tube high speed rotating to stir cell, relies on the negative pressure suction to preserve the liquid entrapped cell to the miillpore filter of film pipe, shifts cell on the filter membrane to microslide through malleation again.The mechanical factor of filtering membrane tube high speed rotating may cause destruction to a certain degree by pair cell; The miillpore filter of consumptive material assembly needs energetic ion or isotope technology to produce micropore; This just caused should technology adapted consumptive material expensive, satisfied inadequately to the production effect of courage and uprightness or mucus sample.In addition, this kind equipment can only be used for smear to be made, and can not realize the robotization dyeing of smear.
Natural subsidence formula liquid based cytology pelleter is commonly called as LCT.The cell collection of natural subsidence formula LCT is roughly similar with TCT with the preservation process, because whole film-making process adopts the specific gravity liquid gradient centrifugation twice, and then carries out film-making and dyeing, makes whole technique process redundant and complicated.And, to operating personnel's experience require high and labour intensity greatly, defectives such as consumptive material assembly complicacy and device fabrication cost height.Therefore, the liquid based cytology film-making dyeing integration equipment that a kind of simple efficient, film-making high-quality of invention and automaticity are high is very necessary concerning the application of the development of current cell pathology subject and clinical cytology inspection.
Summary of the invention
The technical matters that the present invention solved is to provide a kind of and uses injection to move the liquid based cytology film-making of liquid principle and the robot of dyeing integration; Can be as the liquid based cytology film-making dyeing of quick and high-quality, to solve the shortcomings and deficiencies in the above-mentioned background technology.
The technical matters that the present invention solved adopts following technical scheme to realize: the feature structure of liquid basal cell film-making overflow dyeing machine of the present invention comprises machine base; Worktable; Sample moves liquid syringe and moves the liquid syringe seat; Cell-preservation liquid bottle and preservation liquid bottle seat; The film-making plate of may command upset; Reagent moves liquid syringe and moves the liquid syringe seat; Kit; The micro computer kinetic control system; Fuselage; Kit has port lid; Forearm; Horizontal slide rail; Movement arm; Horizontal motor movement device; Horizontal motor; Motor telecontrol equipment up and down; Move liquid syringe operation paw; Top board and side arm.
The fuselage of liquid basal cell film-making overflow dyeing machine of the present invention and forearm support one group of horizontal slide rail, and movement arm is across between two tracks of horizontal slide rail, and horizontal motor movement device and motor telecontrol equipment and move liquid syringe operation paw up and down are housed on the movement arm.
Liquid basal cell film-making overflow dyeing machine of the present invention is characterized in that being divided into moving liquid syringe that sample moves liquid syringe and reagent moves two types of liquid syringes, prevents to pollute between the different samples and between sample and the reagent; Employing moves the liquid cell specimen in liquid syringe suction, mixing and the distributed and saved liquid bottle and uses its accurate quantification imbibition and fluid injection function to carry out the jump operation of sample and reagent.
Four groups of film-makings dyeing unit are installed on the worktable of liquid basal cell film-making overflow dyeing machine of the present invention, and every group of film-making dyeing unit moves liquid syringe by 6 samples of a row and moves liquid syringe seat, 6 cell-preservation liquid bottles of a row and preserve liquid bottle seat and film-making plate that a row can adorn the may command upset in 6 sedimentation film-making storehouses is formed.
On the worktable of liquid basal cell film-making overflow dyeing machine of the present invention kit is installed; Having 5 reagent troughs, kits to have port lid, kit not to have port lid, kit left side on the kit is that 6 reagent of a row move liquid syringe and move the liquid syringe seat, and the volume of each reagent trough is 250 to 300 milliliters.
The cell-preservation liquid bottle of installing on the worktable of liquid basal cell film-making overflow dyeing machine of the present invention has bottle cap; The top of bottle is cylindric and is coniform with the bottom; Be built-in with and filter inner core and sample collection brush, the bottom of filtering inner core is welded with the nylon leaching net of mesh size between 50 to 200 orders.
Beneficial effect of the present invention: liquid basal cell film-making overflow dyeing machine neither needs loaded down with trivial details LCT specific gravity liquid gradient centrifugation step and micro-tubular drainage system, does not also need the negative pressure of vacuum extraction of TCT and the process of miillpore filter malleation transitional cell.Utilization moves liquid syringe suction, mixing, cell dispersion sample and its accurate quantification imbibition and the fluid injection function realizes fluid sample and agent transfer operation; And be divided into moving liquid syringe that sample moves liquid syringe and reagent moves two types of liquid syringes, prevent to pollute between the different samples and between sample and the reagent.The concussion that whole film-making process does not need the additional configuration oscillator to carry out cell specimen disperses.Cell in the sedimentation film-making storehouse relies on its gravity natural subsidence to having on the adhering microslide, carries out robotization dyeing then.Have simple to operately, cost is lower and make the characteristics of the quick high-quality of liquid based cytology smear.
Description of drawings
Through reading the detailed description of non-limiting example being done with reference to following accompanying drawing, other features, objects and advantages of the present invention will become more apparent.
Fig. 1 is the contour structures synoptic diagram of liquid basal cell film-making overflow dyeing machine.
Fig. 2 is the planar structure synoptic diagram of liquid basal cell film-making overflow dyeing machine worktable.
Fig. 3 is the structural representation of facing of liquid basal cell film-making overflow dyeing machine.
Fig. 4 is the side-looking structural representation of liquid basal cell film-making overflow dyeing machine.
Fig. 5 is the structural representation of liquid basal cell film-making overflow dyeing machine kit.
Fig. 6 is the structural representation of cell-preservation liquid bottle.
Fig. 7 is the structural representation in film-making plate and sedimentation film-making storehouse.
Embodiment
In order to understand concrete structure of the present invention and content more carefully, for example the present invention is described further below in conjunction with accompanying drawing.
The structural representation of the liquid basal cell film-making overflow dyeing machine of Fig. 1, Fig. 2, Fig. 3 and different visual angles shown in Figure 4, its feature structure comprise machine base 1, worktable 2,6 samples of a row move liquid syringe and move liquid syringe seat 3,6 cell-preservation liquid bottles of a row and preserve liquid bottle seat 4, a row can adorn film-making plate 5, the reagent of the may command upset in 6 sedimentation film-making storehouses move liquid syringe and move liquid syringe seat 6, kit 7, micro computer kinetic control system 8, fuselage 9, kit have port lid 10, forearm 11, horizontal slide rail 12, movement arm 13, horizontal motor movement device 14, horizontal motor 15, up and down motor telecontrol equipment 16, move liquid syringe operation paw 17, top board 18 and side arm 19.
Fig. 5 is the structural representation of liquid basal cell film-making overflow dyeing machine kit.Having 5 reagent trough 20-24, kits to have port lid 10, kit not to have port lid 25, kit left side on the kit 7 is that 6 reagent of a row move liquid syringe and move liquid syringe seat 6, and the volume of each reagent trough is 250 to 300 milliliters.
Fig. 6 is the structural representation of cell-preservation liquid bottle.Comprise and filter inner core 26, the bottom of filtering inner core is welded with the nylon leaching net 27 of mesh size between 50 to 200 orders.To filter inner core 26 and insert in the cell-preservation liquid bottle 4, the characteristic of preserving the liquid bottle is that top is cylindric and bottom and is coniform 28, fills 10 to 15 ml cells and preserves liquid, puts into bottle to the brush that collects sample 30, builds bottle cap 29.
Fig. 7 is the structural representation in settlement plate and sedimentation film-making storehouse.A row can install 6 microslides and sedimentation film-making storehouse on the film-making plate 5.The microslide 34 of numbering is placed on the film-making plate 6 exactly, and each microslide 34 is put into corresponding microslide groove 35, the symmetrical ear in sedimentation film-making storehouse 32 is picked up the ears two semi-rings on 33 screw-in film-making plate slide groove both sides in 36, and fix.
Structure accompanying drawing below in conjunction with liquid basal cell film-making overflow dyeing machine further specifies the course of work of the present invention and principle.
Like Fig. 6 and shown in Figure 7, collection there is the brush 30 of the Uterine neck bush of cell sample be retained in the cell-preservation liquid bottle 4, build bottle cap, be sent to the laboratory.When the laboratory operation personnel receive preservation liquid bottle; Jolt preservation liquid bottle for several times with hand; After 5 minutes, screw the cap off a bottle 29 with the centrifugal preservation liquid of 2000 rev/mins speed bottle, will filter inner core 26 and abandon from preserving to take out in the liquid bottle 4 in the lump with brush 30; Carefully pour out upper liquid lightly, observing bottle point bottom has cell precipitation 31.Then, with preserving in the preservation liquid bottle seat that liquid bottle 4 is placed on the worktable 2 in order, and with film-making plate 5 on the sample number position of microslide corresponding.
Start energized, computer are according to the programming automation complete operation of writing input, and the operation of machine single can be accomplished the film-making and the dyeing of 24 routine samples at most automatically.As shown in Figure 1; Movement arm 13 drives move liquid syringe operation paw 17 and are moved horizontally to the top position that reagent moves liquid syringe 6; Grasp reagent and move liquid syringe 6; From the buffering liquid groove 20 of kit 7, extract damping fluid, horizontal left is to the top position that every row preserves liquid bottle 4, and syringe injects 1 milliliter of damping fluid in every row's preservation liquid bottle.Then, movement arm 13 drives and moves liquid syringe operation paw 17 levels and move to right and reagent is moved liquid syringe be put back into original position 6.Movement arm 13 drives once more and moves the top position that the moving paraphase of liquid syringe operation paw 17 horizontal left should every stock layout originally moves liquid syringe 3; Grasp sample and move liquid syringe 3; Be inserted in the cell-preservation liquid bottle 4, and liquid is for several times drawn and is shifted about 0.3 to 0.6 milliliters of liquid to the film-making plate 5 in the corresponding sedimentation film-making storehouse in the suction bottle; Wait for the cell natural subsidence after 10 to 20 minutes, film-making plate upset is automatically outwelled Reversion Level original position behind the liquid in the storehouse.Movement arm 13 drive move liquid syringe operation paw 17 again sub-level be shifted to the right to the top position that reagent moves liquid syringe 6, grasp reagent downwards and move liquid syringe 6.Then, repeat from each reagent trough 20-24 of kit 7, to extract respectively the dye liquor and the reagent of aequum, join again in the sedimentation film-making storehouse on every row's film-making plate, finally accomplish the dyeing of cell smear.Behind reagent or water flushing sedimentation film-making storehouse inner room, take off sedimentation film-making storehouse and slide from the film-making plate, carry out mounting and microscopy again.
More than show and described ultimate principle of the present invention and principal character and advantage of the present invention.The technician of the industry should understand; The present invention is not restricted to the described embodiments; That describes in the foregoing description and the instructions just explains principle of the present invention; Under the prerequisite that does not break away from spirit and scope of the invention, the present invention also has various changes and modifications, and these variations and improvement all fall in the scope of the invention that requires protection.The present invention requires protection domain to be defined by the right content and the equivalent thereof of appending claims.
Claims (6)
1. one kind is used injection to move the liquid basal cell film-making overflow dyeing machine of liquid principle, its feature structure comprise that machine base (1), worktable (2), sample move liquid syringe and the film-making plate (5), the reagent that move liquid syringe seat (3), cell-preservation liquid bottle and preserve liquid bottle seat (4), may command upset move liquid syringe and move liquid syringe seat (6), kit (7), micro computer kinetic control system (8), fuselage (9), kit have port lid (10), forearm (11), horizontal slide rail (12), movement arm (13), horizontal motor movement device (14), horizontal motor (15), up and down motor telecontrol equipment (16), move liquid syringe operation paw (17), top board (18) and side arm (19).
2. as claimed in claim 1ly a kind ofly use injection to move the liquid basal cell film-making overflow dyeing machine of liquid principle; The fuselage (9) and the forearm (11) that it is characterized in that it support one group of horizontal slide rail (12); Movement arm (13) is across between two tracks of horizontal slide rail, and horizontal motor movement device (14) and motor telecontrol equipment (16) and move liquid syringe operation paw (17) up and down are housed on the movement arm.
3. as claimed in claim 1ly a kind ofly use injection to move the liquid basal cell film-making overflow dyeing machine of liquid principle; It is characterized in that being equipped with on its worktable (2) four groups of film-makings dyeing unit, every group of film-making dyeing unit moves liquid syringe by 6 samples of a row and moves liquid syringe seat, 6 cell-preservation liquid bottles of a row and preserve liquid bottle seat and film-making plate that a row can adorn the may command upset in 6 sedimentation film-making storehouses is formed.
4. according to claim 1ly a kind ofly use injection to move the liquid basal cell film-making overflow dyeing machine of liquid principle; It is characterized in that being divided into moving liquid syringe that sample moves liquid syringe and reagent moves two types of liquid syringes, prevent to pollute between the different samples and between sample and the reagent; Employing moves the liquid cell specimen in liquid syringe suction, mixing and the distributed and saved liquid bottle and uses its accurate quantification imbibition and fluid injection function to carry out the jump operation of sample and reagent.
5. as claimed in claim 1ly a kind ofly use injection to move the liquid basal cell film-making overflow dyeing machine of liquid principle; It is characterized in that on its worktable (2) kit (7) being installed; Having 5 reagent troughs (20-24), kit to have port lid (10), kit not to have port lid (25), kit left side on the kit is that 6 reagent of a row move liquid syringe and move liquid syringe seat (6), and the volume of each reagent trough is 250 to 300 milliliters.
6. as claimed in claim 1ly a kind ofly use injection to move the liquid basal cell film-making overflow dyeing machine of liquid principle; The last cell-preservation liquid bottle of installing (4) of worktable (2) that it is characterized in that it has bottle cap (29); The top of bottle is cylindric and is coniform (28) with the bottom; Be built-in with and filter inner core (26) and sample collection brush (30), the bottom of filtering inner core (26) is welded with the nylon leaching net (27) of mesh size between 50 to 200 orders.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2012101942010A CN102759474A (en) | 2012-06-13 | 2012-06-13 | Liquid-based cell smear manufacturing and dyeing machine utilizing principles of injection and pipetting |
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| Application Number | Priority Date | Filing Date | Title |
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| CN2012101942010A CN102759474A (en) | 2012-06-13 | 2012-06-13 | Liquid-based cell smear manufacturing and dyeing machine utilizing principles of injection and pipetting |
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| CN102759474A true CN102759474A (en) | 2012-10-31 |
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| CN103558074A (en) * | 2013-10-10 | 2014-02-05 | 广州安必平自动化检测设备有限公司 | Cell-stain apparatus |
| CN105259008A (en) * | 2015-10-30 | 2016-01-20 | 广州鸿琪光学仪器科技有限公司 | Plunger pump sample-adding and dyeing assembly and dyeing machine |
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