CN102743523A - Production process of traditional Chinese medicine for treating anhypnia - Google Patents
Production process of traditional Chinese medicine for treating anhypnia Download PDFInfo
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- CN102743523A CN102743523A CN2012102779251A CN201210277925A CN102743523A CN 102743523 A CN102743523 A CN 102743523A CN 2012102779251 A CN2012102779251 A CN 2012102779251A CN 201210277925 A CN201210277925 A CN 201210277925A CN 102743523 A CN102743523 A CN 102743523A
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- 239000003814 drug Substances 0.000 title claims abstract description 17
- 238000004519 manufacturing process Methods 0.000 title claims abstract description 11
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 28
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 13
- VYQNWZOUAUKGHI-UHFFFAOYSA-N monobenzone Chemical compound C1=CC(O)=CC=C1OCC1=CC=CC=C1 VYQNWZOUAUKGHI-UHFFFAOYSA-N 0.000 claims abstract description 9
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims abstract description 8
- 239000000706 filtrate Substances 0.000 claims abstract description 7
- 239000000843 powder Substances 0.000 claims abstract description 7
- 238000010992 reflux Methods 0.000 claims abstract description 7
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims abstract description 5
- 238000005303 weighing Methods 0.000 claims abstract description 5
- 229920002472 Starch Polymers 0.000 claims abstract description 4
- 235000019359 magnesium stearate Nutrition 0.000 claims abstract description 4
- 239000008107 starch Substances 0.000 claims abstract description 4
- 235000019698 starch Nutrition 0.000 claims abstract description 4
- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 claims description 8
- 206010022437 insomnia Diseases 0.000 claims description 8
- 239000007788 liquid Substances 0.000 claims description 8
- 210000000582 semen Anatomy 0.000 claims description 8
- 241000628997 Flos Species 0.000 claims description 7
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 6
- 238000001694 spray drying Methods 0.000 claims description 6
- 238000001291 vacuum drying Methods 0.000 claims description 6
- 241000255791 Bombyx Species 0.000 claims description 3
- 239000000741 silica gel Substances 0.000 claims description 3
- 229910002027 silica gel Inorganic materials 0.000 claims description 3
- 239000012141 concentrate Substances 0.000 claims description 2
- 238000005469 granulation Methods 0.000 claims description 2
- 230000003179 granulation Effects 0.000 claims description 2
- 239000008213 purified water Substances 0.000 claims description 2
- -1 through reflux Substances 0.000 claims description 2
- 230000000694 effects Effects 0.000 abstract description 10
- 229930003935 flavonoid Natural products 0.000 abstract description 10
- 150000002215 flavonoids Chemical class 0.000 abstract description 10
- 235000017173 flavonoids Nutrition 0.000 abstract description 10
- 229930182490 saponin Natural products 0.000 abstract description 8
- 150000007949 saponins Chemical class 0.000 abstract description 8
- 235000017709 saponins Nutrition 0.000 abstract description 8
- 238000000605 extraction Methods 0.000 abstract description 5
- 238000001914 filtration Methods 0.000 abstract description 4
- 239000007921 spray Substances 0.000 abstract description 3
- 238000001035 drying Methods 0.000 abstract 3
- 239000002775 capsule Substances 0.000 abstract 2
- 240000007185 Albizia julibrissin Species 0.000 abstract 1
- 235000011468 Albizia julibrissin Nutrition 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 238000011049 filling Methods 0.000 abstract 1
- 239000008187 granular material Substances 0.000 abstract 1
- 238000007873 sieving Methods 0.000 abstract 1
- 239000000377 silicon dioxide Substances 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 description 8
- 239000012567 medical material Substances 0.000 description 5
- RANQPHKSRUUPKK-UHFFFAOYSA-N 3-O-[alpha-L-arabinofuranosyl-(1->2)-O-{beta-D-glucopyranosyl-(1->3)}-(alpha-L-arabinopyranosyl)]jujubogenin Natural products CC(C)=CC1CC(C)(O)C2C3CCC4C5(C)CCC(OC6OCC(O)C(OC7OC(CO)C(O)C(O)C7O)C6OC6OC(CO)C(O)C6O)C(C)(C)C5CCC4(C)C33COC2(C3)O1 RANQPHKSRUUPKK-UHFFFAOYSA-N 0.000 description 2
- YKRGDOXKVOZESV-WRJNSLSBSA-N Paeoniflorin Chemical compound C([C@]12[C@H]3O[C@]4(O)C[C@](O3)([C@]1(C[C@@H]42)O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)C)OC(=O)C1=CC=CC=C1 YKRGDOXKVOZESV-WRJNSLSBSA-N 0.000 description 2
- 238000002481 ethanol extraction Methods 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 238000011835 investigation Methods 0.000 description 2
- 229930192286 jujuboside Natural products 0.000 description 2
- 210000004185 liver Anatomy 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 241000202726 Bupleurum Species 0.000 description 1
- 206010010904 Convulsion Diseases 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 206010019705 Hepatic pain Diseases 0.000 description 1
- 208000008454 Hyperhidrosis Diseases 0.000 description 1
- 206010022998 Irritability Diseases 0.000 description 1
- 206010033557 Palpitations Diseases 0.000 description 1
- 208000001431 Psychomotor Agitation Diseases 0.000 description 1
- 206010038743 Restlessness Diseases 0.000 description 1
- 241000219100 Rhamnaceae Species 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000036592 analgesia Effects 0.000 description 1
- 230000000202 analgesic effect Effects 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 230000001914 calming effect Effects 0.000 description 1
- 230000036461 convulsion Effects 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- 229930003944 flavone Natural products 0.000 description 1
- 150000002213 flavones Chemical class 0.000 description 1
- 235000011949 flavones Nutrition 0.000 description 1
- 229930182478 glucoside Natural products 0.000 description 1
- 150000008131 glucosides Chemical class 0.000 description 1
- 230000037315 hyperhidrosis Effects 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 230000005906 menstruation Effects 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- YKRGDOXKVOZESV-UHFFFAOYSA-N paeoniflorin Natural products O1C(C)(C2(CC34)OC5C(C(O)C(O)C(CO)O5)O)CC3(O)OC1C24COC(=O)C1=CC=CC=C1 YKRGDOXKVOZESV-UHFFFAOYSA-N 0.000 description 1
- OXGUCUVFOIWWQJ-HQBVPOQASA-N quercitrin Chemical compound O[C@@H]1[C@H](O)[C@@H](O)[C@H](C)O[C@H]1OC1=C(C=2C=C(O)C(O)=CC=2)OC2=CC(O)=CC(O)=C2C1=O OXGUCUVFOIWWQJ-HQBVPOQASA-N 0.000 description 1
- 239000001397 quillaja saponaria molina bark Substances 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
Landscapes
- Medicines Containing Plant Substances (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention discloses a production process of the traditional Chinese medicine for treating anhypnia. The production process includes the following steps: 1 weighing spina date seeds, radix paeoniae alba, radix bupleuri and albizia julibrissin, adding ethanol, extracting for 1-4 times through reflux, and combining the filtrate; 2 adding water into the obtained dreg, decocting for 1-4 times, combining the decocted medicine solution, standing, and filtering to obtain filtrate; 3 combining the two kinds of obtained filtrate, concentrating, and drying in vacuum or spray mode; 4 adding water into other four medicines, decocting for 2-4 times, wherein each time lasts for 1-3 hours, combining and decocting the obtained medicine solution, standing, filtering, concentrating the filtrate, and drying in vacuum or spray mode; and 5 performing palletizing on the two obtained powder, drying the powder granules, smashing, sieving, adding magnesium stearate, starch and superfine silica powder, and filling the powder in capsules to obtain the traditional Chinese medicine for treating anhypnia. By means of the technical scheme of the production process, effective part flavonoid can be effectively extracted, simultaneously the extraction rate of the effective part saponins is improved, and accordingly, the curing effect of the 'shumian capsule' is remarkably improved.
Description
Technical field
The present invention relates to a kind of production of medicine technology, particularly a kind of production of medicine technology of Cure for insomnia disease.
Background technology
Semen Ziziphi Spinosae: be the dry mature seed of Rhamnaceae plant acid Semen Ziziphi Spinosae, effect such as have tonifying liver, mind calming, promote the production of body fluid, it is thirsty to be mainly used in restlessness of asrhenia type and insomnia, palpitation with fear dreaminess, the empty hyperhidrosis of body, Tianjin wound.Its saponins and flavonoid are its main active component, and Semen Ziziphi Spinosae is that thin layer is differentiated jujuboside a in the SHUMIAN JIAONANG quality standard, so serve as the investigation index with jujuboside a clear spot.
The Radix Paeoniae Alba: be the dry root of Herba Ranunculi Japonici Radix Paeoniae, have effects such as suppressing the hyperactive liver pain relieving, nourishing blood for regulating menstruation.Radix Paeoniae Alba total glucosides is the main effective ingredient in the Radix Paeoniae Alba.Be determined as index with paeoniflorin content in the SHUMIAN JIAONANG quality standard, so be to investigate index with the peoniflorin.
Radix Bupleuri: be umbelliferae bupleurum, Radix Bupeuri Scorzonerfolii. dry root.Have analgesic, analgesia, calmness, convulsion, protect the liver antiinflammatory, improve the function of immunity.Radix Bupleuri total saponin is the main effective ingredient of Radix Bupleuri, for the curative effect of whole medicine plays a part very important.Differentiate to be index with the Radix Bupleuri thin layer in the SHUMIAN JIAONANG quality standard, so clear spot is the investigation index in differentiating with the Radix Bupleuri thin layer.
Flos Albiziae: the dry inflorescence for the leguminous plant Herba Albiziae, have the effect of resolving stagnation for tranquilization, often treat irritability, melancholy insomnia.Total flavones and Quercitroside are main active, so clear spot serves as to investigate index in differentiating with the Flos Albiziae thin layer.
Above four Chinese medicine is the main Chinese medicinal materials of Cure for insomnia disease Chinese medicine " SHUMIAN JIAONANG "; Right ' SHUMIAN JIAONANG " curative effect play main effect; the active component of this four Chinese medicine material mainly is saponins and flavonoid, and saponins water soluble and ethanol, and flavonoid is water insoluble and be dissolved in ethanol.Existing extraction process is the active ingredient that the method that decocts of water is extracted medicine, can't extract the flavonoid active ingredient basically, and flavonoid is the main active ingredient of " SHUMIAN JIAONANG ", so that " SHUMIAN JIAONANG " and curative effect have a greatly reduced quality.Provide a kind of extraction ratio that can improve the active ingredient saponins can effectively extract the technology of active ingredient flavonoid again, with making the curative effect of SHUMIAN JIAONANG that significantly raising arranged.
Summary of the invention
The technical problem that the present invention will solve: can not more effectively extract the defective of Semen Ziziphi Spinosae, the Radix Paeoniae Alba, Radix Bupleuri and Flos Albiziae active ingredient to having technology now, a kind of extraction ratio that can improve saponins is provided, can effectively extract the technology of flavonoid again.
Technical scheme of the present invention:
The first, take by weighing Semen Ziziphi Spinosae, the Radix Paeoniae Alba, Radix Bupleuri and Flos Albiziae, add ethanol, through reflux, extract, 1 ~ 4 time, each reflux, extract, 0.5 ~ 5 hour, extracting solution filters, the merging of will filtrating;
The second, filter the medicinal residues of gained, decoct 1 ~ 4 time after adding water, each 0.5 ~ 5 hour, merge and decoct the gained medicinal liquid, leave standstill, filter, obtain filtrating;
Three, above-mentioned two kinds of filtratings are merged, concentrate vacuum or spray drying;
Four, get Cortex Albiziae, Bombyx Batryticatus, Periostracum Cicadae and Medulla Junci decocte with water 2 ~ 4 times in addition, each 1 ~ 3 hour, merge and decoct the gained medicinal liquid and leave standstill, filter the back concentrated filtrate, vacuum or spray drying;
Five, two kinds of powder of above-mentioned gained are granulated, oven dry, crushing screening adds magnesium stearate, starch and micropowder silica gel, and is encapsulated, promptly gets.
Said concentration of ethanol is 50 ~ 90%, and wherein concentration is 70% ethanol extraction best results.
Beneficial effect of the present invention
Get Semen Ziziphi Spinosae, the Radix Paeoniae Alba, Radix Bupleuri and Flos Albiziae; Pass through reflux, extract, after adding ethanol; Be dissolved in ethanol because flavonoid is water insoluble; So can effectively extract the active ingredient flavonoid with ethanol extraction, improve the extraction ratio of active ingredient saponins simultaneously, make the curative effect of SHUMIAN JIAONANG that significantly raising arranged.The result is shown in table 1 and table 2:
The specific embodiment
The concrete embodiment of the present invention is following:
The first, take by weighing Semen Ziziphi Spinosae 650g, Radix Bupleuri 380g, Radix Paeoniae Alba 380g and Flos Albiziae 480g; The concentration of adding 10 times of medical material amounts is 50 ~ 90% ethanol, and wherein concentration is that 70% ethanol is best, refluxes 2 hours; Filtration obtains filtrating 1; 70% alcohol reflux of 8 times of medical material amounts of medicinal residues reuse 2 hours filters and obtains filtrating 2, merges the filtrating that obtains for twice;
The second, the decocting of 8 times of medical material amounts of medicinal residues reuse boiled 2 hours, obtained decocting liquid 1; The water that medicinal residues add 8 times of medical material amounts decocted 2 hours, obtained decocting liquid 2, and collecting decoction 1 and decocting liquid 2 left standstill 8 hours, filtered to obtain filtrating;
The filtrating of three, two kinds of different solvents being extracted merges back concentrated (concentrating pressure limit 0.1 ~ 0.99Pa, 50 ~ 100 ℃ of temperature ranges) to relative density and is about 1.0 ~ 1.3 (50 ℃), and then vacuum or spray drying;
Four, take by weighing Cortex Albiziae 480g, Bombyx Batryticatus 300g, Periostracum Cicadae 300g and Medulla Junci 30g in addition; The decocting that adds 10 times of medical material amounts boils twice; 2 hours for the first time, 2 hours for the second time, merge twice decoction gained medicinal liquid and left standstill 8 hours; The filtration rear filtrate is concentrated into relative density and is about 1.0 ~ 1.3 (50 ℃), vacuum or spray drying.
Five, with two kinds of powder of above-mentioned gained spray ethanol or purified water mixing granulation, 60 mesh sieves were pulverized in oven dry, added an amount of magnesium stearate and micropowder silica gel, and added starch adjustment total amount and be 400g, and were encapsulated, processed 1000, promptly got.
Claims (3)
1. the production technology of the Chinese medicine of a Cure for insomnia disease, its characteristic comprises following steps:
The first, take by weighing Semen Ziziphi Spinosae, the Radix Paeoniae Alba, Radix Bupleuri and Flos Albiziae, add ethanol, through reflux, extract, 1 ~ 4 time, refluxed 0.5 ~ 5 hour at every turn, extracting solution filters, the merging of will filtrating;
The second, filter the medicinal residues of gained, decoct 1 ~ 4 time after adding water, each 0.5 ~ 5 hour, merge and decoct the gained medicinal liquid, leave standstill, filter, obtain filtrating;
Three, above-mentioned two kinds of filtratings are merged, concentrate vacuum or spray drying;
Four, get Cortex Albiziae, Bombyx Batryticatus, Periostracum Cicadae and Medulla Junci decocte with water 2 ~ 4 times in addition, each 1 ~ 3 hour, merge and decoct the gained medicinal liquid and leave standstill, filter the back concentrated filtrate, vacuum or spray drying;
Five, with two kinds of powder mixes of above-mentioned gained, with purified water or alcohol granulation, 60 mesh sieves were pulverized in oven dry, added magnesium stearate, starch and micropowder silica gel, and were encapsulated, promptly got.
2. the production technology of the Chinese medicine of a kind of Cure for insomnia disease according to claim 1 is characterized in that: said concentration of ethanol is 50 ~ 90%.
3. the production technology of the Chinese medicine of a kind of Cure for insomnia disease according to claim 2 is characterized in that: said concentration of ethanol is 70% for best.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN2012102779251A CN102743523A (en) | 2012-08-07 | 2012-08-07 | Production process of traditional Chinese medicine for treating anhypnia |
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| Application Number | Priority Date | Filing Date | Title |
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| CN2012102779251A CN102743523A (en) | 2012-08-07 | 2012-08-07 | Production process of traditional Chinese medicine for treating anhypnia |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103223027A (en) * | 2013-04-22 | 2013-07-31 | 王国恩 | Medicinal preparation for treating and preventing vegetative nerve functional disturbance diseases |
| WO2018042384A1 (en) * | 2016-09-02 | 2018-03-08 | Pharmacogenetics Limited | Compositions of medicinal plants for reducing the effects of aging, prevention and treatment of age-related neurodegenerative diseases, and treatment of anxiety and sleep disorders |
| CN109966379A (en) * | 2018-12-03 | 2019-07-05 | 贵州大隆药业有限责任公司 | A kind of pharmaceutical composition and preparation method thereof for insomnia |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101167898A (en) * | 2007-11-07 | 2008-04-30 | 贵州大隆药业有限责任公司 | Traditional Chinese medicine preparation for treating insomnia |
-
2012
- 2012-08-07 CN CN2012102779251A patent/CN102743523A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101167898A (en) * | 2007-11-07 | 2008-04-30 | 贵州大隆药业有限责任公司 | Traditional Chinese medicine preparation for treating insomnia |
Non-Patent Citations (4)
| Title |
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| 南京中医药大学: "《中药大辞典》", 31 March 2006, 上海科学技术出版社 * |
| 彭伟等: "解郁安神法治疗亚健康状态失眠151例", 《山东中医药大学学报》 * |
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Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103223027A (en) * | 2013-04-22 | 2013-07-31 | 王国恩 | Medicinal preparation for treating and preventing vegetative nerve functional disturbance diseases |
| CN103223027B (en) * | 2013-04-22 | 2015-07-22 | 王国恩 | Medicinal preparation for treating and preventing vegetative nerve functional disturbance diseases |
| WO2018042384A1 (en) * | 2016-09-02 | 2018-03-08 | Pharmacogenetics Limited | Compositions of medicinal plants for reducing the effects of aging, prevention and treatment of age-related neurodegenerative diseases, and treatment of anxiety and sleep disorders |
| CN109641023A (en) * | 2016-09-02 | 2019-04-16 | 华晶基因技术有限公司 | For delaying senescence, old neurodegenerative disease, and the Chinese herbal medicine efficient combination for the treatment of anxiety and sleep disturbance disease are prevented and treated |
| US10722547B2 (en) | 2016-09-02 | 2020-07-28 | Pharmacogenetics Limited | Compositions of medicinal plants for reducing the effects of aging, prevention and treatment of age-related neurodegenerative diseases, and treatment of anxiety and sleep disorders |
| CN109641023B (en) * | 2016-09-02 | 2021-11-05 | 华晶基因技术有限公司 | An effective combination of Chinese herbal medicine for delaying aging, preventing and treating senile neurodegenerative diseases, anxiety and sleep disorders |
| CN109966379A (en) * | 2018-12-03 | 2019-07-05 | 贵州大隆药业有限责任公司 | A kind of pharmaceutical composition and preparation method thereof for insomnia |
| CN109966379B (en) * | 2018-12-03 | 2021-08-17 | 贵州大隆药业有限责任公司 | Pharmaceutical composition for insomnia and preparation method thereof |
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Application publication date: 20121024 |