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CN102740713A - High fiber nutritional emulsions for blood glucose control - Google Patents

High fiber nutritional emulsions for blood glucose control Download PDF

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Publication number
CN102740713A
CN102740713A CN201080026016XA CN201080026016A CN102740713A CN 102740713 A CN102740713 A CN 102740713A CN 201080026016X A CN201080026016X A CN 201080026016XA CN 201080026016 A CN201080026016 A CN 201080026016A CN 102740713 A CN102740713 A CN 102740713A
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emulsion
weight
fiber
oil
aqueous emulsion
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N.K.埃登斯
V.A.马斯塔德
J.E.沃尔顿
D.R.沃尔夫
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Abbott GmbH and Co KG
Abbott Laboratories
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A—HUMAN NECESSITIES
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    • A23D—EDIBLE OILS OR FATS, e.g. MARGARINES, SHORTENINGS OR COOKING OILS
    • A23D7/00—Edible oil or fat compositions containing an aqueous phase, e.g. margarines
    • A23D7/005—Edible oil or fat compositions containing an aqueous phase, e.g. margarines characterised by ingredients other than fatty acid triglycerides
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    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
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    • A23L33/115—Fatty acids or derivatives thereof; Fats or oils
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/16—Inorganic salts, minerals or trace elements
    • A23L33/165—Complexes or chelates
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/17—Amino acids, peptides or proteins
    • A23L33/19—Dairy proteins
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/20—Reducing nutritive value; Dietetic products with reduced nutritive value
    • A23L33/21—Addition of substantially indigestible substances, e.g. dietary fibres
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/40—Complete food formulations for specific consumer groups or specific purposes, e.g. infant formula
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

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Abstract

Disclosed are nutritional aqueous emulsions having high fiber content. These emulsions comprise fat, protein, and carbohydrate, including (a) from 1.75% to about 4.0% by weight of a diacylglycerol oil; (b) from about 0.5% to about 9.0% by weight of a milk protein concentrate; (c) from about 2.0% to about 9.0% by weight of fiber; and (d) fructose and from about 0.15% by weight of leucrose in a weight ratio of fructose to leucrose of at least 2:1, wherein the aqueous emulsion has a viscosity of at least about 300 centipoise at 20 DEG C. These high fiber emulsions provide beneficial features, including one or more of stability, desirable hedonics, rheology, and product performance, including a blunted glycemic response profile and/or minimal or no gastrointestinal intolerance.

Description

The high fiber nutrient emulsion that is used for glycemic control
The application is referred to the U.S. Provisional Patent Application submitted on April 14th, 2009 number 61/169,030 and requires its priority.
Technical field
The present invention relates to have the nutrition emulsion of low viscosity and high fibre concentration.
Background technology
There is the many dissimilar emulsion that is suitable for as independent nutrient source or the Orally administered people of giving in extra-nutrition source based on milk or protein.Generally these emulsions are prepared into the oil in water emulsion that comprises fat, protein, carbohydrate, vitamin and mineral matter.The instance of this emulsion comprises can derive from Abbott Laboratories, Columbus, the ENSURE Nutritional Liquid of Ohio USA and GLUCERNA Shake.
Many interpolation fibers in these nutrition emulsions and preparing are to provide in many benefits any.Think that the suitable absorption of fiber reduces the risk that various illnesss such as heart disease, diabetes, diverticulosis and constipation take place.Usually fiber is formulated in the nutrition emulsion to help to reduce the glycemic index (glycemic index) of carbohydrate containing emulsion; This can be useful to many individualities, comprise the diabetic and to the relevant interested individuality of many benefits of liter sugar reaction of conditioned more.
In view of many benefits of high fibre diet, usually advise the dietary fiber of children and per day for adults consumption at least 20 grams.In fact, the calorie of individual consumption every day is many more, and the fiber that he or she needs for health diet is many more.For example, teenager and adult male can need 30-35 gram fiber or more fiber every day, and these concrete meals that depend on them are taken in.
Though in most of meals, need high relatively fiber content, the American only consumes the fiber of about 15 grams average every day, although a lot of food is strengthened with the fiber that adds.Therefore, exist nutrition product like demand based on the emulsion of protein or milk, its with high relatively fibre concentration preparation to satisfy the nutritional need of ordinary consumer better.
Yet the nutrition emulsion prescription with higher fiber concentration usually produces many problems, and the some of them problem is unique for the matrix of emulsion-based.High fiber content can damage emulsion stability, and it is necessary that demand to harsh processing temperature is become, and reduces the intestines and stomach tolerance, and produce that the sensation of not expecting (hedonics) is poor like mouthfeel, the sense of sand shape, local flavor change etc.
Therefore, have the needs to following nutrition emulsion, it comprises higher fibre concentration, but also have low relatively and thereby drinkable viscosity, but not have in relevant with the high fiber emulsion in the past negative factor some or whole.
Summary of the invention
First embodiment of nutrition emulsion comprises fat, protein and carbohydrate; And comprise: (a) 1.75% diacylglycerol oil to about 4.0% weight; (b) about 0.5% milk protein concentrate to about 9.0% weight, (c) about 2.0% to the fiber of about 9.0% weight and (d) fructose and at least about 0.15% lucrose; The weight ratio of fructose and lucrose is 2:1 at least, and wherein this emulsion has the viscosity less than about 300 centipoises.
Second embodiment of nutrition emulsion comprises about 5% carbohydrate to about 40% weight, about 2% fat and about 0.5% protein to about 15% weight to about 30% weight; Wherein this emulsion comprises: (a) the about 1.75% diacylglycerol oil to about 4.0% weight; (b) about 0.5% milk protein concentrate to about 9.0% weight; (c) about 2.0% fiber to about 9.0% weight, (d) fructose and about 0.15% lucrose, the weight ratio of fructose and lucrose is 2:1 at least; (e) about 0.0020% of this emulsion to about 0.00010% chromium picolinate by weight, wherein this aqueous emulsion has the viscosity less than about 300 centipoises under 20 ℃.
These alimentation compositions are water-based oil in water emulsion; Although its fiber content is high; But have the physics of expectation under various conditions and sensation, rheology and the properties of product of chemical stability and expectation, comprise the liter sugar reaction overview (blunted glycemic response profile) and/or the intestines and stomach intolerance minimum or that do not have of passivation.In the time of in being contained in the packing with the most of inner surface (this surface is plastics rather than metal, glass or other non-frosting) that contacts with nutrition emulsion, this emulsion is particularly useful.
Description of drawings
Fig. 1 is the figure from research I, and it illustrates with the fasting plasma insulin concentration (mmole/L) that replenishes in the Zucker fa/fa rat of raising with the meals of A1, A2 and A3 prescription the 0th, 14 and 28 day.
Fig. 2 is the figure from research I, and it illustrates to replenishing the Zucker fa/fa rat with A1, A2 and A3 prescription, like the difference in the insulin sensitivity of measuring through insulin tolerance test (in the change of blood sugar of raising the back stipulated time by force).
Fig. 3 is the figure from research I, and it illustrates with the glycosylated hemoglobin (%) that replenishes in the Zucker fa/fa rat of raising with the meals of A1, A2 or A3 prescription the 0th and 28 day.The 0th day to the 28th day glycosylated hemoglobin changes the top indication by each diagram rod.
Fig. 4 is the figure from research II, and it illustrates with the research meals or replenish voluntarily in the Zucker fa/fa rat of raising with the research meals of A1 prescription the 0th, 14 and 28 day fasting plasma insulin concentration (pmol/L).This figure shows that the voluntary consumption of A1 prescription weakens the rising of the plasma insulin of in control group, seeing (*: p < 0.05).
Fig. 5 is the figure from research II, and it illustrates with the research meals or replenish voluntarily in the Zucker fa/fa rat of raising with the research meals of A1 prescription 0,30,60,90 and 120 minute blood sugar (mg/dl) level behind injection of insulin (p < 0.05).
Fig. 6 is the figure from research II, and it illustrates therein with the research meals or replenishes the 0th day and the 28th day with the research of the meals raising rat of A1 prescription, the glycosylated hemoglobin (%) in Zucker fa/fa rat voluntarily.The top of rod is the variation to the 28th day glycosylated hemoglobin in the 0th day from research.The voluntary consumption of A1 prescription weakens the glycosylated hemoglobin of in supplementation group not, being seen and raises.
Fig. 7 is the figure from research III, and its total foodstuff that shows the Zucker fa/fa rat of raising with control Food or half purified diet (research meals) is taken in (kilocalorie), and prompting is to the preference of better to eat research meals.
Fig. 8 is the figure from research III, and it shows the accumulation food intake (kilocalorie) of the Zucker fa/fa rat of raising with independent research meals or additional research meals of filling a prescription with A1.This figure show animal rat select to reduce to good to eat, preferably study the consumption of meals, to compensate for them as the calorie of A1 prescription consumption (p < 0.05).
The specific embodiment
High fiber nutrient emulsion can comprise: the various combinations of diacylglycerol oil, fiber, fructose and lucrose, milk protein concentrate and glycerine and other optional or other composition.Facing the essential characteristic of this nutrition emulsion and some in many optional modification down is described in detail.
Only if point out in addition, the term that uses among this paper " nutrition emulsion " means the aqueous emulsion that is suitable for human oral is used and comprised fat, protein, carbohydrate.
Only if point out in addition, the term that uses among this paper " fat " and " oil " use interchangeably, to refer to from the lipid material of plant or animal derived or processing.
Only if point out in addition, the term that uses among this paper " high fiber " mean by weight as nutrition emulsion about 1.5% to about 9%, about 2.3% to about 9% fibre concentration more typically.
Only if point out in addition, the term that uses among this paper " sensation " can refer to one or more in the following properties of nutrition emulsion: fragrance, mouthfeel, quality, taste and color or physical appearance.
The term that uses among this paper " rheology " can refer to the viscoelastic properties of the expectation of nutrition emulsion; Viscoelastic properties under the storage temperature that be included in various conditions, for example increases or reduce is with emulsion and/or suspending agent stability and other characteristic of the increase of reflection nutrition emulsion.
Only if point out in addition; The term that uses among this paper " properties of product " can refer to the benefit of the expectation of packing nutrition emulsion described herein, and wherein this benefit comprises one or more in following: the intestines and stomach tolerance increases, desirably the reaction of the liter of passivation sugar, insulin sensitivity increase, the liter sugar reaction of the passivation of meals and the packing of product of expectation are interacted at different time and under particular cases.
Only if point out in addition, all viscosity numbers that this paper quotes are to utilize the Brookfield viscosimeter (DV-II+ type) with 62 axles to obtain down or under the temperature of appointment like this in room temperature (20 ℃).Measure viscosity through operation viscosimeter under for the axle speed of maximum speed that can obtain reading on the scale.The viscosity number of measuring is represented the ratio of shear stress and shear rate, and it is expressed as dyne-second/cm 2Perhaps pool perhaps more typically is expressed as centipoise (cps) or centipoise(unit of dynamic viscosity.
Only if point out in addition, all percentages that adopt among this paper, umber and be by general composition weight meter than all.This weight of when belonging to ingredients listed all is all based on activity level, and therefore do not comprise the solvent or the accessory substance that possibly comprise in the commercially available material, only if point out in addition.
Like what use among this paper, should comprise corresponding plural characteristic or characteristic to any mentioning of single characteristic or characteristic, vice versa, only if point out in addition.
Only if point out in addition, the method that this paper adopted or the combination in any of procedure of processing can be carried out by random order.
The various embodiments of nutrition emulsion can be substantially free of any concrete composition described herein, and condition is that remaining nutrition emulsion comprises all described in this paper and limits basically.In this context; Term " is substantially free of " and means that composition comprises disclosed definite composition less than this paper of function, typically less than about 1.0%, comprise less than about 0.5%, also comprise and also comprise definite composition of 0 % weight less than about 0.1%.
The various embodiments of nutrition emulsion can comprise any in essential characteristic described herein or the composition and can be used for this paper of nutrition emulsion or describe in addition any in addition or optional characteristic or composition, by said characteristic or one-tenth is grouped into or be grouped into by said characteristic or one-tenth basically.
The number range that adopts among this paper intention comprises each numerical value that comprises in this scope and the subclass of numerical value, and no matter whether it is by concrete open.In addition, these number ranges any number or claim of numerical value subclass that should be interpreted as relating in this scope provides support.For example, from 1 to 10 disclosure should be interpreted into 2 to 8,3 to 7,5 to 6,1 to 9,3.6 to 4.6,3.5 to 9.9 etc. the scope of supporting.
Product form
Nutrition emulsion is the aqueous systems of oil-in-water, Water-In-Oil or multiple emulsion form, although the most typically, emulsion is the oil in water emulsion with continuous water and discontinuous oil phase.Water content changes between each emulsion, but the most typically, scope is by weight about 70% to about 90%, more typically about 75% to about 85% of this emulsion.
Nutrition emulsion at room temperature and/or have drinkable viscosity when before consumption, being frozen.Therefore, emulsion can have room temperature (20 ℃) measure down less than about 300 cps, the viscosity of about 10 cps typically to about 160 cps and more typically about 20 cps to about 70 cps.
Can be with the nutrient preparation of nutrition emulsion with enough kinds and amount; With the nutrient source that provides unique, main or replenish, perhaps be provided for suffering from specified disease or illness special nutritional emulsion like the individuality of for example diabetes or other impaired glucose tolerance illness.
These nutrition emulsions also can have the product density greater than about 1.055 g/mL, comprise 1.06 g/mL to 1.08 g/mL.
Can be in suitable glass, plastics, metal or other container with the sterilization of nutrition emulsion autoclave or aseptic packaging; Although found advantageously with the plastics with the plastic interior surfaces that contact with emulsion or other nonmetal and non-glass container or packed preparation, this plastic interior surfaces accounts for the major part of the inner surface area of container or packing.When being used for emulsion and experience autoclave sterilization (retort sterilization) and packing, these packings are particularly useful.
Diacylglycerol
Nutrition emulsion can comprise the diacylglycerol oil as defining among this paper.The concentration range of this diacylglycerol oil be by weight emulsion at least about 1%, comprise about 1.75% to about 4%, and also comprise about 1.8%, and also comprise about 1.9% to about 2.7% to about 3%.
Term " diacylglycerol oil (diacylglycerol oil) " is art-recognized term, and as used herein being meant comprises about by weight 60% to 100%, as to comprise about 70% to about 85% diglyceride processing oil.Diacylglycerol oil can account for fat in the emulsion by weight about 10% to 100%, comprise about 40% to about 80% and comprise about 50% to about 70%.
Diacylglycerol oil is well-known in field of nutrition, and generally comprises the admixture of monoglyceride, diglyceride and triglycerides, and wherein diglyceride accounts for the wherein major part of glyceride.These oil generally are vegetable oil such as the soybean oil and/or the cupu oils of processing, and it comprises about by weight 80% diglyceride and other glyceride of about by weight 20%, i.e. triglycerides and monoglyceride.Diglyceride can comprise the C16-24 fatty acid ester, comprises the C16-20 fatty acid ester, the most typically oleic acid, linoleic acid and/or linolenic ester.The limiting examples that is applicable to the diacylglycerol oil of this paper is to derive from Kao Health and Nutrition, Itasca, Illinois, the Enova Oil of USA.
Although nutrition emulsion can comprise in the multiple natural oil any; Most or all of natural oil contain a spot of diacylglycerol (DGDG) (diglyceride), but these natural oils do not comprise the diglyceride of diacylglycerol oil component enough relative quantities, that represent this paper emulsion.
Nutrition emulsion can further comprise the lecithin with the combination of diacylglycerol oil.Lecithin concentration can be emulsion by weight at least about 0.1%, comprise about 0.16% to about 0.5% scope.
The diacylglycerol composition can be replaced; And oily admixture capable of using is kept the physical stability of the expectation of filling a prescription described in this paper; This oil admixture comprises all 30% to 50% high oleic safflower oil by oily admixture weight, 20% to 40% Tower rape oil, 15% to 35% soybean oil and 1% to 10% lecithin respectively, comprises 40/30/25/5 admixture of these oil.The replacement admixture can with for the identical concentration of diacylglycerol composition under use, said concentration is the weight by the nutrition emulsion of finished product described in this paper.
Fiber
Nutrition emulsion with account for emulsion by weight about at least 1.5%, comprise about 2.0% to about 9% and also comprise about 2.1% to about 6% and comprise that also about 2.2% to about 4.3% level contains fiber.Fiber can account for total carbohydrates in the emulsion by weight about 10% to 100%, comprise about 12% to about 40% and also comprise about 15% to about 25%.
The fiber that is used for this paper generally is meant not absorbed perhaps by body and is not resolved into those compositions in little molecule and the absorbed then nutrition product in addition by the enzyme of people's alimentary canal.Fiber can comprise and is suitable for Orally administered any known fiber or fibre source in the nutrition product, comprises solubility and/or fiber or its source insoluble, that can ferment and maybe can not ferment, perhaps its combination or variant.
Be based on that fiber is dissolved in the ability in the buffer solution under the regulation pH value, the fiber that is used for this paper can be divided into solvable type and insoluble type.Aspect the solubility that each fibre source comprises at them and the amount of insoluble fibre is different.Only if point out in addition, solubility as used herein and insoluble fibre title and concentration thereof or amount and comprise total fiber concentration and utilize Association of Official Analytical Chemists (AOAC) Method 991.43 to confirm.
Being used for the soluble dietary fiber of this paper or the limiting examples of fiber source comprises: Arabic gum, sodium carboxymethylcellulose, guar gum, citrus pectin, low-methoxy and HM, oat beta-glucan and barley, carrageenan and psyllium (psyllium).Numerous commercial source of soluble dietary fiber can get.For example, Arabic gum, hydrolyzed carboxymethylcellulo, e, guar gum, pectin and LM and HM can derive from TIC Gums, Inc., Belcamp, Maryland.Oat beta-glucan and barley can derive from Mountain Lake Specialty Ingredients, Inc., Omaha, Nebraska.Psyllium can derive from Meer Corporation, North Bergen, and New Jersey, and carrageenan can derive from FMC Corporation, Philadelphia, Pennsylvania.
Being used for the insoluble diedairy fiber of this paper or the limiting examples of fiber source comprises: oat hull fiber, pea hide fiber, soybean skin fiber, cotyledon fiber, beet fiber, cellulose and corn bran.Numerous sources of insoluble diedairy fiber also can get.For example, corn bran can derive from Quaker Oats, Chicago, Illinois; The oat hull fiber can derive from Canadian Harvest, Cambridge, Minnesota; The pea hide fiber can derive from Woodstone Foods, Winnipeg, Canada; Soybean skin fiber and oat hull fiber can derive from The Fibrad Group, LaVale, Maryland; Cotyledon fiber can derive from Protein Technologies International, St. Louis, Missouri; Beet fiber can derive from Delta Fiber Foods, Minneapolis, Minnesota; And cellulose can derive from James River Corp., Saddle Brook, New Jersey.
The fiber that is used for this paper also can comprise: FOS (FOS) comprises that the degree of polymerization is 2 to 10,3 to 7 FOS the most typically; And/or inulin, comprise that the degree of polymerization is at least 10, comprises about 20 to about 50 inulin; And/or grape oligosaccharides (GOS).FOS, GOS and/or inulin can account for fiber in the nutrition emulsion by weight 0 to about 50%, comprise about 5% to about 30%, comprise about 10% to about 20%.As used herein, the fiber content of FOS can confirm according to Association of Official Analytical Chemists (AOAC) Method 997.08, perhaps is assumed to be about 96% of FOS by weight in addition.
A commercial fibres source that is applicable to this paper is Fibersol-2, and it is the Soluble Fiber source that comprises the dietary fiber of about 37% weight, and it can derive from ADM Company, Decatur, Illinois, USA.
Nutrition emulsion also can comprise at least about 1.20:1, comprise that about 1.23:1 is to about 5:1 and also comprise about 1.24:1 extremely fiber and the oily weight ratio of diacylglycerol of about 1.8:1.
Sugar
Nutrition emulsion can comprise low relatively sugared concentration, its scope for emulsion by weight 0 to about 2.1%, comprise about 0.5% to about 1.8% and also comprise about 0.9% to about 1.7%.So, emulsion also can have the high fiber/sugared ratio greater than about 1:1, comprises from about 20:1 to about 1:1 and also comprises about 1.4:1 extremely from about 3:1.
In this context, term " sugar " refers to the summation of monose and disaccharides in the emulsion.
In the nutrition emulsion total carbohydrates can be at least about 5:1 with the ratio of sugar, comprise about 5.5:1 to about 20:1, comprise extremely about 10:1 and also comprise the extremely scope of about 9:1 of about 7:1 of about 6:1.
Nutrition emulsion can further comprise artificial sweetener, for example asccharin, Aspartame, Sucralose, knob sweet (neotame), acesulfame potassium or its combination.Artificial sweetener can be at least about 0.0060:1 with the ratio of sugar, comprise about 0.0070:1 to about 0.0300:1, comprise the extremely scope of about 0.0095:1 of about 0.0080:1.
Nutrition emulsion also can comprise glycerine as sweetener, and it can compare Combination application with artificial sweetener/sugar as herein described with sugar (under low sugar concn as herein described) and artificial sweetener.
Milk protein concentrate (milk protein concentrate)
Nutrition emulsion can comprise milk protein concentrate (MPC), and this concentrate can account for some of protein in the emulsion or all.Emulsion can comprise emulsion by weight at least about 0.5%, comprise about 1% to about 9% and also comprise the MPC of about 2% to about 6% concentration.
The suitable milk protein concentrate that is used for this paper comprises any this concentrate that is applicable to the oral nutrient product.In this context, term " milk protein concentrate " is meant dairy product, its have generally account for this dairy products by weight about 40% to about 88%, comprise about 60% to about 80% and comprise about 65% to about 75% protein content.Milk protein concentrate generally also comprises a spot of lactose and butterfat.
Glycerine
Nutrition emulsion can comprise glycerine, its concentration can account for nutrition emulsion by weight about 2.0% to about 6.0%, comprise about 2.1% to about 4.0% and also comprise about 2.2% to about 3.0%.
Suitable glycerine source comprises any glycerol product that is applicable to the oral nutrient product.
Fructose and lucrose
Nutrition emulsion can comprise the combination of fructose and lucrose; Wherein lucrose account for nutrition emulsion by weight at least about 0.15%, comprise about 0.15% to about 1.0% and also comprise nutrition emulsion by weight about 0.30% to about 0.40%, wherein the weight ratio of fructose and lucrose is at least about 1.5:1, comprises that about 2:1 is to about 20:1 and also comprise extremely about 8:1 of about 2.8:1.
Can individually or in combination fructose and lucrose be added in the nutrition emulsion.The commercial source of a this combination can be used as Cargill ' s Sucromalt SM05 syrup and derives from Cargill Sweetener Solutions; Minneapolis; Minnesota; USA, it comprises about 37% fructose, 13% lucrose, 48% sugar and other disaccharides of 2% on dry basis.
Chromium picolinate
Nutrition emulsion can be suitable for comprising chromium picolinate under the Orally administered concentration.This concentration can be by weight emulsion at least about 0.002%, comprise about 0.0020% to about 0.00010% and also comprise about 0.0010% to about 0.00040% and also comprise about 0.00090% to about 0.00060% scope.
Can chromium picolinate be formulated in the nutrition emulsion as herein described, when using, to assist glycemic control with other nutrient combination described herein.
Macronutrient (macronutrients)
Nutrition emulsion comprises fat, protein and carbohydrate.Usually, known or be applicable to that in addition any source of fat, protein and the carbohydrate of oral nutrient product also is suitable for using in this article, condition be this nutrient also with prescription in other is compatible through selection component.
Although the total concentration of fat, protein and carbohydrate or amount can change according to intention user's nutritional need; Specialize in the scope in the scope below but this concentration or amount the most typically drop on, comprise other essential fat, protein and/or carbohydrate component as described herein.
Carbohydrate concentration the most typically be by weight nutrition emulsion about 5% to about 40%, comprise about 7% to about 30%, comprise about 10% to about 25% scope; Fatty consistency the most typically be by weight nutrition emulsion about 2% to about 30%, comprise about 3% to about 15% and also comprise about 5% to about 10% scope; And, protein concentration the most typically be by weight nutrition emulsion about 0.5% to about 30%, comprise about 1% to about 15% and comprise about 2% to about 10% scope.
As herein describedly be used for the suitable fat of nutrition emulsion or the limiting examples in its source comprises: diacylglycerol oil as described herein, lecithin as described herein, coconut oil, fractionated coconut oil, soybean oil, corn oil, olive oil, safflower oil, high oleic safflower oil, MCT oil (medium chain triglyceride), sunflower oil, high oleic sunflower oil, palm oil and palm-kernel oil, palm olein, Tower rape oil, bunker oil (marine oil), cottonseed oil and combination thereof.
Being used for the suitable carbohydrate of nutrition emulsion described herein or the limiting examples in its source can comprise: the carbohydrate that the starch of maltodextrin, hydrolysis or modification or cornstarch, glucose polymer, corn syrup, corn in solids syrup, rice derive, glucose, fructose, lactose, high-fructose corn syrup, honey, sugar alcohol (for example, maltitol, antierythrite, D-sorbite) and combination thereof.
Being used for the suitable protein of nutrition emulsion or the limiting examples in its source comprises: the protein of hydrolysis, partial hydrolysis or non-hydrolysis or protein source; It can be derived from any known or other suitable source; For example milk (as, casein, whey), animal (as, meat, fish), cereal (as; Rice, corn), vegetables (like, soybean) or its combination.The limiting examples of this protein comprises: milk proem matter separator, milk protein concentrate as described herein, casein protein separator, whey protein, caseinate, full milk, partially or completely defatted milk, soybean protein separator, soy protein concentrate etc.
Optional member
Nutrition emulsion can further comprise physics, chemistry, sensation or the processing characteristics that can change product or when being used for target group, serve as medicine or other optional member of other nutritional labeling.Many this optional members are known or be applicable to other nutrition product in addition and also can be used for the nutrition emulsion described in this paper, condition be this optional member for Orally administered be safety with effectively and compatible with essential composition and other composition in the selected product form.
The limiting examples of this optional member comprises: anticorrisive agent, anti-oxidant, emulsifying agent, buffer, active constituents of medicine, other nutrient as herein described, colouring agent, flavor enhancement (flavor), thickener and stabilizing agent (for example, carrageenan, microcrystalline cellulose), sterol, phytosterol, turmeric, lubricant etc.
Nutrition emulsion can further comprise vitamin or relevant nutrient, and its limiting examples comprises: vitamin A, vitamin D, vitamin E, vitamin K, thiamine, riboflavin, pyridoxol, cobalamin, carotenoid, nicotinic acid, folic acid, pantothenic acid, biotin, vitamin C, choline, inositol, salt and derivative thereof and combination thereof.
Nutrition emulsion can further comprise mineral matter, and its limiting examples comprises: calcium, phosphorus, magnesium, iron, zinc, manganese, copper, sodium, potassium, molybdenum, chromium, selenium, chloride and combination thereof.
The preparation method
Nutrition emulsion can be through being used to prepare nutrition emulsion, the most typically being to be used to prepare the nutrition aqueous emulsion or based on any conventional method or the known method preparation in addition of the emulsion of milk.
In a kind of suitable conventional preparation method, prepare 2 kinds or more kinds of independent slurry, wherein a kind of slurry is fat free basically water-based slurry.One or more other slurries can comprise: the water slurry body (for example, the protein in the water) and the other carbohydrate-mineral matter slurry of the fats/oils slurry of protein (for example, protein, fat, emulsifying agent or surfactant etc.), protein.At last, in the fusion jar, a plurality of slurries are combined experience uht, homogenate, the vitamin, mineral matter or other optional member that inject to add, and dilute with water on demand.
This preparation technology can further comprise resulting nutrition emulsion is packaged in the proper container, and this container can be for example metal, glass or plastics, and can be Reclosable.This method can comprise further that also the nutrition emulsion with packing is exposed to autoclave sterilization (retort packaged) nutrition emulsion with preparation autoclave sterilization packaging.The autoclave sterilization is the procedure of processing that the formulation art those of ordinary skill is known, and relates to the nutraceutical high-temperature process of packing liquid as the one of which.Nutrition emulsion also can carry out aseptic packaging rather than autoclave sterilization.
The preparation technology of nutrition emulsion is not critical, and under the situation that does not deviate from spirit and scope of the invention, can adopt other method except that methods described herein to implement.Therefore, it is illustrative rather than restrictive that embodiment of the present invention all are considered in all respects, and all variations and equivalent are also in description of the invention.
Surprisingly, found that some combination with the composition of describing disclosed herein can be high fiber nutrient emulsion unexpected benefit is provided now.One or more in these unexpected benefits can be the results of the synergistic combination of 2 kinds or more kinds of compositions described in this paper.Compare with conventional nutrition emulsion, a kind of or more kinds of combination of special component described in this paper can be high fiber emulsion and gives improvement and unexpected characteristic.In one embodiment, the combination of the composition in the high fiber emulsion can provide the liter sugar of improvement to react together with higher calorie content.In another embodiment, the combination of the composition in the high fiber emulsion can provide the high stability high fiber emulsion of the low temperature process preparation that can utilize more expectation, although have high fiber content.In another embodiment, the composition of high fiber emulsion can provide the sensation of improvement and the intestines and stomach tolerance of improvement, the passivation liter sugar reaction that high fiber, higher calorie is provided simultaneously and improves.
The new component admixture that is used for high fiber emulsion described in this paper can comprise following composition any 2,3,4,5 or more kinds of any combinations, said composition can be separately (even synergistic combination ground) surprising benefit of facilitating above-mentioned high fiber emulsion individually or in combination: diacylglycerol oil, milk protein concentrate, sucromalt, fiber, FOS, insoluble fibre, turmeric, glycerine, chromium picolinate, have monounsaturated fatty acids class, lucrose and the fructose of 16-24 carbon atom.That is, any in these compositions can with any or the more kinds of combination in other composition, and can be resulting high fiber emulsion surprising benefit be provided.
Embodiment
Following embodiment has explained the specific embodiments and/or the characteristic of nutrition emulsion.It is restriction that given embodiment just is interpreted into for illustrative purposes and not, because in the present invention without departing from the spirit and scope of the present invention many variations can be arranged.
Embodiment 1-4
These embodiment have explained nutrition embodiment of the present disclosure, during its composition is listed in the table below.Only if point out in addition, the amount of all the components is listed with " kg/1000 kg criticizes product ".Prescription is the aqueous emulsion of stable storage.
Prepare in the slurry oil body of prescription through water slurry body and the independent protein of conventional method through proper composition being combined to independent carbohydrate-mineral matter slurry, independent protein.For each other slurry, under temperature that is suitable for selected materials and shearing force, each composition is mixed, in the fusion jar, different slurries is made up then, through uht (UHT), and homogenate under about 3000 psi then.Subsequently, vitamin, flavor enhancement and other thermo-sensitive material are added in the homogenate mixture.As required, with resulting mixture dilute with water, to obtain the concentration and the density (about 1.0628 g/mL) of expectation.Then, to resulting nutrition emulsion sterilize with the autoclave sterilization packaging in the plastic bottle of 8 oz (ounce).Selected bottle has the narrow neck of extending 1-5 cm from the packing major part of broad.
This exemplary composition the time provides the characteristic of expectation in packing, comprises the characteristic of one or more expectations, for example the sensation of physics or chemistry or emulsion stability, expectation, favourable rheological characteristic or viscoelastic characteristic and properties of product defined herein.This prescription is physically stable in packing with when storing up to 18 months down for 20 ℃; And the liter sugar reaction of passivation is provided and has minimum or do not have the intestines and stomach intolerance, particularly rise sugared reaction pair it will be that useful other are when individual being used for diabetic or this passivation.
Composition Embodiment 1 Embodiment 2 Embodiment 3 Embodiment 4
Water QS QS QS QS
Fibersol-2 TM1 52.6 68.6 137.2 205.7
Milk protein concentrate 38.5 38.5 38.5 38.5
Sucromalt 2 36.4 36.4 36.4 36.4
Glycerine 22.0 22.0 22.0 22.0
Enova TMOil 3 18.6 18.6 18.6 18.6
Soy protein concentrate 18 18 18 18
MALTRIN ? M100 4 10.6 10.6 10.6 10.6
Tower rape oil 7.8 7.8 7.8 7.8
FOS 5.0 6.5 13.0 19.6
The phytosterol ester 3.2 3.2 3.2 3.2
High oleic safflower oil 3.1 3.1 3.1 3.1
Magnesium phosphate 2.4 2.4 2.4 2.4
Flavor enhancement 3.3 3.3 3.3 3.3
Potassium citrate 2.0 2.0 2.0 2.0
Natrium citricum 2.0 2.0 2.0 2.0
Soybean lecithin (5%OB) is dissolved in soybean oil 1.6 1.6 1.6 1.6
Potassium chloride 0.900 0.900 0.900 0.900
Calcium phosphate 0.670 0.670 0.670 0.670
Choline Chloride 0.6515 0.6515 0.6515 0.6515
Sodium chloride 0.650 0.650 0.650 0.650
Ascorbic acid 0.5841 0.5841 0.5841 0.5841
Magnesium chloride 0.5000 0.5000 0.5000 0.5000
Viscarin SA-359 5 0.4500 0.4500 0.4500 0.4500
45%KOH solution 0.4181 0.4181 0.4181 0.4181
UTM/TM/WSV 0.2717 0.2717 0.2717 0.2717
Liquid Sucralose (25%) 0.1600 0.1600 0.1600 0.1600
Acesulfame potassium 0.0940 0.0940 0.0940 0.0940
The turmeric concentrate 0.0750 0.0750 0.0750 0.0750
Vitamin D EK pre-composition 0.0651 0.0651 0.0651 0.0651
Vit. A Palm. (54% oil) 0.0091 0.0091 0.0091 0.0091
KI 220 mg 220 mg 220 mg 220 mg
Cobalamin 16 mg 16 mg 16 mg 16 mg
(total fiber) 2.3% 3.0% 6.0% 9.0%
1. Soluble Fiber source: the dietary fiber of 37% weight; ADM Company, Decatur, Illinois USA
2. Sucromalt SM05 syrup has 37% fructose, 13% lucrose (dry weight); Cargill, Minneapolis, MN, USA
3. diacylglycerol is oily: Kao Health and Nutrition, Itasca, IL USA
4. maltodextrin DE 9-12; Grain Processing Corporation, Muscatine Iowa
5. carrageenan: FMC Biopolymer, Philadelphia, Pennsylvania, USA.
Embodiment 5-8
These embodiment have explained nutrition embodiment of the present disclosure, during its composition is listed in the table below.Except as otherwise noted, all the components amount is listed with " kg/1000 kg criticizes product ".This prescription is the aqueous emulsion of stable storage, and it is according to preparation of the method described in the embodiment 1-4 and packing.
Composition Embodiment 5 Embodiment 6 Embodiment 7 Embodiment 8
Water QS QS QS QS
Fibersol
2 52.6 52.6 52.6 52.6
Milk protein concentrate 38.5 38.5 38.5 38.5
Sucromalt 36.4 36.4 36.4 36.4
Glycerine 22.0 22.0 22.0 22.0
Enova TMOil 20.0 25.0 30.0 40.0
Soy protein concentrate 18 18 18 18
Maltrin M 100 10.6 10.6 10.6 10.6
Tower rape oil 7.8 7.8 7.8 7.8
FOS 5.0 5.0 5.0 5.0
The phytosterol ester 3.2 3.2 3.2 3.2
High oleic safflower oil 3.1 3.1 3.1 3.1
Magnesium phosphate 2.4 2.4 2.4 2.4
Flavor enhancement 3.3 3.3 3.3 3.3
Potassium citrate 2.0 2.0 2.0 2.0
Natrium citricum 2.0 2.0 2.0 2.0
Soybean lecithin (5%OB) is dissolved in soybean oil 1.6 1.6 1.6 1.6
Potassium chloride 0.900 0.900 0.900 0.900
Calcium phosphate 0.670 0.670 0.670 0.670
Choline Chloride 0.6515 0.6515 0.6515 0.6515
Sodium chloride 0.650 0.650 0.650 0.650
Ascorbic acid 0.5841 0.5841 0.5841 0.5841
Magnesium chloride 0.5000 0.5000 0.5000 0.5000
Viscarin SA-359 0.4500 0.4500 0.4500 0.4500
45%KOH solution 0.4181 0.4181 0.4181 0.4181
UTM/TM/WSV 0.2717 0.2717 0.2717 0.2717
Liquid Sucralose (25%) 0.1600 0.1600 0.1600 0.1600
Acesulfame potassium 0.0940 0.0940 0.0940 0.0940
The turmeric concentrate 0.0750 0.0750 0.0750 0.0750
Vitamin D EK pre-composition 0.0651 0.0651 0.0651 0.0651
Vit. A Palm. (54% oil) 0.0091 0.0091 0.0091 0.0091
KI 220 mg 220 mg 220 mg 220 mg
Cobalamin 16 mg 16 mg 16 mg 16 mg
(total fiber) 2.3% 2.3% 2.3% 2.3%
Embodiment 9-12
These embodiment have explained nutrition embodiment of the present disclosure, during its composition is listed in the table below.Except as otherwise noted, all the components amount is listed with " kg/1000 kg criticizes product ".This prescription is the aqueous emulsion of stable storage, and it is according to preparation of the method described in the embodiment 1-4 and packing.
Composition Embodiment 9 Embodiment 10 Embodiment 11 Embodiment 12
Water QS QS QS QS
Fibersol
2 52.6 52.6 52.6 52.6
Milk protein concentrate 10 30 60 90
Sucromalt 36.4 36.4 36.4 36.4
Glycerine 22.0 22.0 22.0 22.0
Enova TMOil 18.6 18.6 18.6 18.6
Soy protein concentrate 18 18 18 18
Maltrin M 100 10.6 10.6 10.6 10.6
Tower rape oil 7.8 7.8 7.8 7.8
FOS 5.0 5.0 5.0 5.0
The phytosterol ester 3.2 3.2 3.2 3.2
High oleic safflower oil 3.1 3.1 3.1 3.1
Magnesium phosphate 2.4 2.4 2.4 2.4
Flavor enhancement 3.3 3.3 3.3 3.3
Potassium citrate 2.0 2.0 2.0 2.0
Natrium citricum 2.0 2.0 2.0 2.0
Soybean lecithin (5%OB) is dissolved in soybean oil 1.6 1.6 1.6 1.6
Potassium chloride 0.900 0.900 0.900 0.900
Calcium phosphate 0.670 0.670 0.670 0.670
Choline Chloride 0.6515 0.6515 0.6515 0.6515
Sodium chloride 0.650 0.650 0.650 0.650
Ascorbic acid 0.5841 0.5841 0.5841 0.5841
Magnesium chloride 0.5000 0.5000 0.5000 0.5000
Viscarin SA-359 0.4500 0.4500 0.4500 0.4500
45%KOH solution 0.4181 0.4181 0.4181 0.4181
UTM/TM/WSV 0.2717 0.2717 0.2717 0.2717
Liquid Sucralose (25%) 0.1600 0.1600 0.1600 0.1600
Acesulfame potassium 0.0940 0.0940 0.0940 0.0940
The turmeric concentrate 0.0750 0.0750 0.0750 0.0750
Vitamin D EK pre-composition 0.0651 0.0651 0.0651 0.0651
Vit. A Palm. (54% oil) 0.0091 0.0091 0.0091 0.0091
KI 220 mg 220 mg 220 mg 220 mg
Cobalamin 16 mg 16 mg 16 mg 16 mg
(total fiber) 2.3% 2.3 2.3 2.3
Embodiment 13-16
These embodiment have explained nutrition embodiment of the present disclosure, during its composition is listed in the table below.Except as otherwise noted, all the components amount is listed with " kg/1000 kg criticizes product ".This prescription is the aqueous emulsion of stable storage, and it is according to preparation of the method described in the embodiment 1-4 and packing.
Composition Embodiment 13 Embodiment 14 Embodiment 15 Embodiment 16
Water QS QS QS QS
Fibersol
2 52.6 52.6 52.6 52.6
Milk protein concentrate 38.5 38.5 38.5 38.5
Sucromalt 36.4 36.4 36.4 36.4
Glycerine 25.0 30.0 35.0 40.0
Enova TMOil 18.6 18.6 18.6 18.6
Soy protein concentrate 18 18 18 18
Maltrin M 100 10.6 10.6 10.6 10.6
Tower rape oil 7.8 7.8 7.8 7.8
FOS 5.0 5.0 5.0 5.0
The phytosterol ester 3.2 3.2 3.2 3.2
High oleic safflower oil 3.1 3.1 3.1 3.1
Magnesium phosphate 2.4 2.4 2.4 2.4
Flavor enhancement 3.3 3.3 3.3 3.3
Potassium citrate 2.0 2.0 2.0 2.0
Natrium citricum 2.0 2.0 2.0 2.0
Soybean lecithin (5%OB) is dissolved in soybean oil 1.6 1.6 1.6 1.6
Potassium chloride 0.900 0.900 0.900 0.900
Calcium phosphate 0.670 0.670 0.670 0.670
Choline Chloride 0.6515 0.6515 0.6515 0.6515
Sodium chloride 0.650 0.650 0.650 0.650
Ascorbic acid 0.5841 0.5841 0.5841 0.5841
Magnesium chloride 0.5000 0.5000 0.5000 0.5000
Viscarin SA-359 0.4500 0.4500 0.4500 0.4500
45%KOH solution 0.4181 0.4181 0.4181 0.4181
UTM/TM/WSV 0.2717 0.2717 0.2717 0.2717
Liquid Sucralose (25%) 0.1600 0.1600 0.1600 0.1600
Acesulfame potassium 0.0940 0.0940 0.0940 0.0940
The turmeric concentrate 0.0750 0.0750 0.0750 0.0750
Vitamin D EK pre-composition 0.0651 ? 0.0651 0.0651
Vit. A Palm. (54% oil) 0.0091 0.0091 0.0091 0.0091
KI 220 mg 220 mg 220 mg 220 mg
Cobalamin 16 mg 16 mg 16 mg 16 mg
Total fiber 2.3% 2.3 2.3 2.3
Embodiment 17-20
These embodiment have explained nutrition embodiment of the present disclosure, during its composition is listed in the table below.Except as otherwise noted, all the components amount is listed with " kg/1000 kg criticizes product ".This prescription is the aqueous emulsion of stable storage, and it is according to preparation of the method described in the embodiment 1-4 and packing.
Composition Embodiment 17 Embodiment 18 Embodiment 19 Embodiment 20
Water QS QS QS QS
Fibersol
2 52.6 52.6 52.6 52.6
Milk protein concentrate 38.5 38.5 38.5 38.5
Sucromalt 30 35 40 50
Glycerine 22.0 22.0 22.0 22.0
Enova TMOil 18.6 18.6 18.6 18.6
Soy protein concentrate 18 18 18 18
Maltrin M 100 10.6 10.6 10.6 10.6
Tower rape oil 7.8 7.8 7.8 7.8
FOS 5.0 5.0 5.0 5.0
The phytosterol ester 3.2 3.2 3.2 3.2
High oleic safflower oil 3.1 3.1 3.1 3.1
Magnesium phosphate 2.4 2.4 2.4 2.4
Flavor enhancement 3.3 3.3 3.3 3.3
Potassium citrate 2.0 2.0 2.0 2.0
Natrium citricum 2.0 2.0 2.0 2.0
Soybean lecithin (5%OB) is dissolved in soybean oil 1.6 1.6 1.6 1.6
Potassium chloride 0.900 0.900 0.900 0.900
Calcium phosphate 0.670 0.670 0.670 0.670
Choline Chloride 0.65 5 0.6515 0.6515 0.6515
Sodium chloride 0.650 0.650 0.650 0.650
Ascorbic acid 0.5841 0.5841 0.5841 0.5841
Magnesium chloride 0.5000 0.5000 0.5000 0.5000
Viscarin SA-359 0.4500 0.4500 0.4500 0.4500
45%KOH solution 0.4181 0.4181 0.4181 0.4181
UTM/TM/WSV 0.2717 0.2717 0.2717 0.2717
Liquid Sucralose (25%) 0.1600 0.1600 0.1600 0.1600
Acesulfame potassium 0.0940 0.0940 0.0940 0.0940
The turmeric concentrate 0.0750 0.0750 0.0750 0.0750
Vitamin D EK pre-composition 0.0651 0.0651 0.0651 0.0651
Vit. A Palm. (54% oil) 0.0091 0.0091 0.0091 0.0091
KI 220 mg 220 mg 220 mg 220 mg
Cobalamin 16 mg 16 mg 16 mg 16 mg
Total fiber 2.3% 2.3% 2.3% 2.3%
Research I
In this research, embodiment of the present invention (A1) is estimated the insulin sensitivity benefit with respect to independent contrast (A2 and A3).A1 is a balanced nutrients prescription of the present invention, and A1 and prescription A2 (Carb-chromium) and A3 (carb-protein-chromium) are compared, and A2 and A3 prescription only comprise the selection component of A1 and do not comprise the essential balance formula of wanting required for the present invention.
Figure 875714DEST_PATH_IMAGE001
In the preparation of present embodiment, with 32 male Zucker Fa/faRat (9 weeks, 5 day age, body weight is 0.423 kg when the research beginning) is divided into three groups (n=10-11) being complementary with body weight.Make rat can arbitrarily obtain half purifying granulating meals (" research meals "), it is intended to simulate low-quality standard U.S. meals, because it is rich in saturated fat and promotion sugar charcoal hydrate.In addition, make rat can obtain a kind of among 3 kinds of replenisher liquid A1, A2 or A3.A1 is a balanced nutrients embodiment of the present invention.A2 comprises the functional carbohydrate of A1 and the solution of chromium picolinate.A3 is the solution of the functional carbohydrate, chromium and the protein that comprise A1.Preparation A2 and A3 solution make functional carbohydrate (Fibersol, Sucromalt and glycerine) (2.83 kilocalories/gram) and protein (milk protein concentrate and soy protein concentrate) (3.46 kilocalories/restrain) level of seeing in the rat consumption A1 prescription.
Have at feeding and to replenish or unsupplemented research meals after 0,14 and 28 days, gather the blood sample of overnight fasting, carry out glucose, insulin, glycosylated hemoglobin analysis.Giving before the rat study meals at once and after feeding in 28 days, measuring insulin resistance.In order to measure insulin resistance, to rat injection regular insulin (the 1 U/kg body weight of overnight fasting; Humulin , Eli Lilly Company).Before the injection of insulin and injection back 30,60,90 and 120 minutes, obtain blood sample from the tail point.Recover during off-test to subsist.
Between 28 days feeding periods, supplement composition does not influence fasting blood-glucose concentration.Surprisingly, compare with A1, A3 and A2 increase plasma insulin (referring to Fig. 1; P 0.01, in the 14th day, A2 and A1 were relatively).Compare with A1, A3 makes insulin sensitivity variation (referring to Fig. 2) significantly.From the 0th day to the 28th day, compare with 0.2% of A1, A2 replenishes the rising 0.9% (Fig. 3) that increases glycosylated hemoglobin.
Based on above-mentioned assessment; Find surprisingly: compare with the voluntary oral ingestion of complete A1 prescription, the voluntary oral ingestion of the supposition functional component (Fibersol, Sucromalt, glycerine, chromium picolinate, milk protein concentrate and soy protein concentrate) of A1 prescription makes insulin sensitivity and metabolism control variation.Therefore, the beneficial effect of A1 prescription can not be explained by any indivedual compositions, and must be the disclosed complete equipilibrium prescription of this paper.
Research II
Carry out research, wherein to insulin sensitivity and glycosylated hemoglobin assessment embodiment of the present invention.
In the preparation of research, with 20 male Zucker Fa/faRat (in 9 ages in week, the body weight during the research beginning is 0.36 kilogram) divides to go into 2 groups, 10 every group, is complementary with body weight.Give rat feeding " research meals ", i.e. half purifying granulating meals, it is intended to simulate low-quality standard U.S. meals, because it is rich in saturated fat and promotion sugar charcoal hydrate, comprises sucrose and maltodextrin.Give independent research meals of rat feeding (" do not have and replenish ") or the meals that replenish with aforementioned formula A1.
Have at feeding and to replenish or do not have the research meals that replenish after 0,14 and 28 days, gather the overnight fasting blood sample, carry out glucose, insulin, glycosylated hemoglobin analysis.Before giving rat feeding research meals at once with feeding 14 days after, measure insulin resistance.Rat overnight fasting 16 hours is also gathered blood sample on an empty stomach in 0 time from tail point.Then immediately to rat injection regular insulin (1 U/kg body weight; Humulin , Eli Lilly Company).Behind injection of insulin 30,60,90 and 120 minutes, obtain blood sample from the tail point.Recover during off-test to subsist.
With the additional blood sugar concentration that do not influence of A1 prescription.Surprisingly, the voluntary consumption of A1 has reduced plasma insulin concentration (referring to Fig. 4) and has improved insulin resistance (referring to Fig. 5).During studying, glycosylated hemoglobin concentration increases by 2.1% (Fig. 6), but surprisingly, consumes Viking 2 voluntarily and only limits these 4 weeks and only increase to 0.6%.Do not force the rat consumption Viking 2 in these experiments.Only make them except that their good to eat meals of height that are rich in fat and sugar, also can obtain this prescription.Surprisingly, these prediabetes rats consume enough A1 prescriptions of one's own accord to improve its insulin sensitivity, as what measured by plasma insulin concentration and insulin resistance test.In addition, surprisingly, in these prediabetes rats, A1 prescription voluntary oral ingestion only can limit by glycosylated hemoglobin higher fatty acid, that high-sucrose research meals cause and raise in 4 weeks significantly.
Research III
Carry out research, wherein to satiety recruitment evaluation embodiment of the present invention.
In the preparation of this research, with 40 male Zucker Fa/faRat (in 9 ages in week, body weight is 0.36 kilogram when the research beginning) is divided into 4 groups, 10 every group.Each group is complementary with body weight.Give a kind of in two kinds of solid meals of rat feeding.First kind is control Food Harlan 2018 (Harlan-Teklad; Madison, WI), and second kind be " research meals "; It is half purifying granulating meals; Be intended to simulate low-quality standard U.S. meals,, comprise sucrose and maltodextrin because it is rich in saturated fat and promotion sugar charcoal hydrate.Give the rat feeding without the solid meals that replenish (independent control Food is perhaps studied meals), perhaps to those same solid meal supplement aforementioned formula A1 (liquid).
Experimental diet is provided 28 days.The feeding solid particle meals through on the wire cage tops, giving the about 50 g foods of rat, and the leftover of weighing every day.The situation (spillage) that consideration is overflowed.The feeding liquid dietary (A1 prescription) through bottle being attached to the cage front portion.Measure consumption figure through weighing to bottle.Abandon and clean bottle with outmoded meals every day, and fresh liquid and solid meals are provided.To random feeding solid of all rats and liquid dietary.
As expectedly, compare with control Food, the research meals have increased food intake and body weight (p < 0.05, referring to Fig. 7).This shows with the common food meals compares, and higher fatty acid, high-sucrose research meals are preferred, and the prompting rat finds that research meals height is good to eat.Yet when making it can obtain the A1 prescription, rat consumes about 1000 kilocalories voluntarily in research process.Surprisingly, rat select to reduce to good to eat, preferably study the consumption of meals, (p < 0.05 as the calorie of A1 prescription consumption to compensate for it; Referring to Fig. 8).This prompting A1 prescription is good to eat surprisingly and satiety is arranged, and causes rat to reduce the absorption to preferred solid meals.

Claims (20)

1. comprise the aqueous emulsion of fat, protein and carbohydrate, it comprises:
(a) 1.75% diacylglycerol oil to about 4.0% weight;
(b) about 0.5% milk protein concentrate to about 9.0% weight;
(c) about 2.0% fiber to about 9.0% weight; With
(d) fructose and about 0.15% lucrose, the weight ratio of fructose and lucrose are 2:1 at least,
Wherein said aqueous emulsion has the viscosity less than about 300 centipoises under 20 ℃.
2. the described aqueous emulsion of claim 1, wherein said emulsion comprise about 5% carbohydrate to about 40% weight, about 2% fat and about 1% protein to about 15% weight to about 30% weight.
3. the described aqueous emulsion of claim 2, wherein said emulsion comprise about 2.0% to about 6% fiber of said emulsion by weight.
4. the described aqueous emulsion of claim 2, wherein said fiber account for about 12% to about 40% of total carbohydrates in the said by weight emulsion.
5. the described aqueous emulsion of claim 2, wherein said fiber comprises FOS, and said FOS accounts for about 5% to about 50% of fiber in the said by weight emulsion.
6. the described aqueous emulsion of claim 2, wherein said emulsion comprise about 1.8% to about 3% diacylglycerol oil of said emulsion by weight.
7. the described aqueous emulsion of claim 2, wherein said diacylglycerol oil account for about 40% to about 80% of total fat in the said by weight emulsion.
8. the described aqueous emulsion of claim 2, wherein said emulsion have fiber and the diacylglycerol oily weight ratio of about 1.20:1 to about 5:1.
9. the described aqueous emulsion of claim 2, wherein said composition have the viscosity of about 10 centipoises to about 160 centipoises under 20 ℃.
10. the described aqueous emulsion of claim 2, it further comprises about 0.1% lecithin to about 0.5% weight.
11. the described aqueous emulsion of claim 2, it further comprises chromium picolinate.
12. the described aqueous emulsion of claim 2, it further comprises carrageenan.
13. the described aqueous emulsion of claim 2, it further comprises turmeric.
14. comprise about 5% carbohydrate to about 40% weight, about 2% fat and about 1% aqueous emulsion to the protein of about 15% weight to about 30% weight, wherein said emulsion comprises:
(a) about 1.75% diacylglycerol oil to about 4.0% weight;
(b) about 0.5% milk protein concentrate to about 9.0% weight;
(c) about 2.0% fiber to about 9.0% weight;
(d) fructose and about 0.15% lucrose, the weight ratio of fructose and lucrose be at least 2:1 and
(e) about 0.1 mg% is to the chromium picolinate of about 2.0 mg %,
Wherein said aqueous emulsion has the viscosity less than about 300 centipoises under 20 ℃.
15. the described aqueous emulsion of claim 2, wherein said emulsion comprise about 2% to about 6% fiber of said emulsion by weight.
16. the described aqueous emulsion of claim 2, wherein said fiber account for about 12% to about 40% of carbohydrate in the said by weight emulsion.
17. the described aqueous emulsion of claim 2, wherein said fiber comprises FOS, and said FOS accounts for about 5% to about 50% of fiber in the said by weight emulsion.
18. the described aqueous emulsion of claim 2, wherein said emulsion comprise about 1.8% to about 3% diacylglycerol oil of said emulsion by weight.
19. the described aqueous emulsion of claim 2, wherein said diacylglycerol oil account in the said by weight emulsion about 40% to about 80% of total fat.
20. the described aqueous emulsion of claim 2, wherein said emulsion have the weight ratio of about 1.20:1 to fiber and the diacylglycerol oil of about 5:1.
CN201080026016XA 2009-04-14 2010-04-13 High fiber nutritional emulsions for blood glucose control Pending CN102740713A (en)

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US9897565B1 (en) 2012-09-11 2018-02-20 Aseko, Inc. System and method for optimizing insulin dosages for diabetic subjects
US9171343B1 (en) 2012-09-11 2015-10-27 Aseko, Inc. Means and method for improved glycemic control for diabetic patients
US9898585B2 (en) 2014-01-31 2018-02-20 Aseko, Inc. Method and system for insulin management
US9486580B2 (en) 2014-01-31 2016-11-08 Aseko, Inc. Insulin management
US11081226B2 (en) 2014-10-27 2021-08-03 Aseko, Inc. Method and controller for administering recommended insulin dosages to a patient
AU2015339576B2 (en) 2014-10-27 2020-02-06 Glytec, Llc Subcutaneous outpatient management
CA2993275C (en) 2015-08-20 2022-06-21 Aseko, Inc. Diabetes management therapy advisor

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101340822A (en) * 2005-12-21 2009-01-07 艾博特公司 Induced-viscosity nutritional emulsions

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MY115050A (en) * 1995-10-16 2003-03-31 Mead Johnson Nutrition Co Diabetic nutritional product having controlled absorption of carbohydrate
US20040209953A1 (en) * 2002-12-06 2004-10-21 Wai Lee Theresa Siu-Ling Glyceride compositions and methods of making and using same
US8067356B2 (en) * 2003-07-15 2011-11-29 Nestec S.A. High fibre high calorie liquid or powdered nutritional composition
WO2008140064A1 (en) * 2007-05-07 2008-11-20 Bbk Bio Corporation Nutrient composition for prevention and amelioration of lifestyle-related disease

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101340822A (en) * 2005-12-21 2009-01-07 艾博特公司 Induced-viscosity nutritional emulsions

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
ALEX K. EAPEN ET AL: "A 28-day oral (dietary) toxicity study of sucromalt in Sprague–Dawley rats", 《FOOD AND CHEMICAL TOXICOLOGY》, 31 December 2007 (2007-12-31) *

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