CN102727808B - Drugs to quickly treat menstrual cramps and abdominal lumps - Google Patents
Drugs to quickly treat menstrual cramps and abdominal lumps Download PDFInfo
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- CN102727808B CN102727808B CN201210215667.4A CN201210215667A CN102727808B CN 102727808 B CN102727808 B CN 102727808B CN 201210215667 A CN201210215667 A CN 201210215667A CN 102727808 B CN102727808 B CN 102727808B
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Abstract
The present invention discloses a drug for rapidly treating dysmenorrheal and abdomen mass. The drug can be prepared into any one oral formulation by adopting peach seed, safflower, white peony root, angelica, salvia miltiorrhiza, cassia bark, flatspine pricklyash, galangal, licorice root and nutgrass galingale rhizome as raw materials according to a certain weight ratio and adopting a conventional process of traditional Chinese drug pharmacy. Results of clinical observation and laboratory tests show that the drug of the present invention provides significant treatment effects for endometriosis and various types of dysmenorrheal, ovarian cysts, uterine fibroids, and other abdomen masses, and advantages of safety after administration, rapid effect, and no toxic and side effect are provided.
Description
technical field
The present invention relates to the medicine of a kind of fast treating dysmenorrhea and abdominal mass, particularly relate to a kind of take botanical herbs and be all that the Chinese medicine of Chinese medicine health care product or medicine-food two-purpose is that make as raw material, treatment dysmenorrhea that there is the treating both the principal and secondary aspects of a disease function and the medicine of abdominal mass.
Background technology
In recent years, the sickness rate of adult female's dysmenorrhea obviously rises.Because life stress, operating pressure strengthen; female menstrual period protection, healthy reproduction are left in the basket; the probability that the diseases such as endometriosis, adenomyosis, ovarian cyst, hysteromyoma, inflammatory bag be fast occur increases, and directly has influence on women's reproductive performance with physically and mentally healthy.
Endometriosis is clinical common disease, and the position of the activated endometriosis of cording beyond in uterus causes morbidity.According to reports indicate that, this sick sickness rate increased more in the past.Because this disease symptoms is obvious, the dysmenorrhea endurable, have larger adverse effect to patient's physical and mental health.
Generally, Endometriosis incidence is the Western medicine symptomatic treatment of pain relieving commonly used often, but this is only makeshift, and disease itself is not improved, and is difficult to the effect that performance effects a permanent cure.
The treatment aspect of endometriosis in uterus, clinical Western medicine commonly used is nemestran, danazol etc., kind is more single, and these medicines have certain side effect, particularly to the infringement of liver function, causes some patients were to use.And, aspect Chinese medicine, the Chinese patent medicine that is exclusively used in the treatment endometriosis is not yet found at present.
Based on the endometriosis clinical treatment, need, we observe through research for many years, the approach such as, blood circulation promoting and blood stasis dispelling stagnant by promoting the flow of QI in the collateral by warming the meridian, regulating the flow of vital energy, find can reach endometriosis the effect of the pain relieving that effects a permanent cure, and meeting medicine must safe and effective basic principle.Because the blood stasis dispelling effect of selected medicine is obvious, there is qi depression to blood stasis arteries and veins card person for the pathologic enclosed mass of gynecological's abdominal part, possess equally the reliable curative effect of dwindling lump and even eliminating lump.
In the medicine of blood circulation promoting and blood stasis dispelling, often there is certain side effect, the patient takes medicine safely and effectively, is very important.Select the Chinese medicine by medicine-food two-purpose and health-care effect to form prescription, its safety is guaranteed, and subject range is more extensive.Moreover, effectively controlling on the basis of dysmenorrhea, developing the Chinese medicine that has therapeutical effect for the lump of qi depression to blood stasis arteries and veins card, is the gynecological clinic problem demanding prompt solution.
Use that traditional Chinese medical science promoting the flow of QI in the collateral by warming the meridian, regulating the flow of vital energy are stagnant, the theoretical prescription of blood circulation promoting and blood stasis dispelling, treat the medicine of dysmenorrhea and gynecological mass simultaneously, make a general survey of Chinese medicine and western medicine market, such medicine still belongs to blank.
Summary of the invention
The object of the invention is to, the medicine of a kind of fast treating dysmenorrhea and abdominal mass is provided, this medicine has the yang-energy of rousing oneself, promoting the flow of QI in the collateral by warming the meridian, stagnant, the blood circulation promoting and blood stasis dispelling that disappears of regulating the flow of vital energy, detumescence is except the effect of disease, the dysmenorrhea that the treatment endometriosis causes, and can be for diseases such as gynecological's abdominal mass are as fast as ovarian cyst, hysteromyoma, inflammatory bag, curative effect is reliable, take effect rapidly, treating both the principal and secondary aspects of a disease, for clinical, provides a kind of novel, safe, efficient medicine.
The present invention is achieved through the following technical solutions: the medicine of a kind of fast treating dysmenorrhea and abdominal mass, it is characterized in that it is to be made by the crude drug of following weight parts: Semen Persicae 6-60 part, Flos Carthami 6-60 part, Radix Paeoniae Alba 6-45 part, Radix Angelicae Sinensis 6-60 part, Radix Salviae Miltiorrhizae 3-60 part, Cortex Cinnamomi 6-60 part, Pericarpium Zanthoxyli 3-45 part, Rhizoma Alpiniae Officinarum 6-60 part, Radix Glycyrrhizae 3-45 part, Rhizoma Cyperi 6-60 part.
Above-mentioned fast treating dysmenorrhea with preferred weight part of each raw material of medicine for the treatment of abdominal mass is: Semen Persicae 10-45 part, Flos Carthami 10-45 part, Radix Paeoniae Alba 10-40 part, Radix Angelicae Sinensis 10-50 part, Radix Salviae Miltiorrhizae 10-45 part, Cortex Cinnamomi 10-45 part, Pericarpium Zanthoxyli 10-36 part, Rhizoma Alpiniae Officinarum 10-45 part, Radix Glycyrrhizae 10-36 part, Rhizoma Cyperi 10-45 part.
Above-mentioned raw materials medicine and consumption formula, be that the inventor draws on the clinical experience basis in more than 30 year, all has significant curative effect in above-mentioned amount ranges.
The present invention be take traditional determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs as basic norm, rouse oneself the yang-energy promoting the flow of QI in the collateral by warming the meridian by this medicine, vital energy regualting and blood circulation-promoting is removed pain, the stagnant dissipation lump of blood stasis dispelling row, medication is made a distinction between the important and the lesser one, fill a prescription ingenious appropriate, dialectically with differential diagnosis of diseases, be combined, Chinese and Western medicine is closed ginseng, medicine used all proves that through the relevant pharmacological evaluation of modern medicine it promotes the tissue blood circulation, promotes produce effects and reliability that tissue absorbs, prove produce effects and the reliability of its blood stasis dispelling, dredging collateral, pain relieving, detumescence, and every herbal medicine all do not have obvious toxic and side effects through the prompting of pharmacology of Chinese materia medica Research Literature.
Medicament selection Semen Persicae of the present invention, Flos Carthami, the Radix Paeoniae Alba, Radix Angelicae Sinensis, Radix Salviae Miltiorrhizae, Cortex Cinnamomi, Pericarpium Zanthoxyli, Rhizoma Alpiniae Officinarum, Radix Glycyrrhizae, Rhizoma Cyperi 10 flavor medicines carry out compatibility, each efficacy of drugs produces synergism, entirely can enough realize rousing oneself yang-energy, temperature three-way meridian, blood-activating analgetic, the effect of dissipation lump.
Semen Persicae, Flos Carthami blood circulation promoting and blood stasis dispelling in side, strengthen the local organization blood circulation; Radix Angelicae Sinensis, Radix Paeoniae Alba nourishing blood and promoting blood circulation, take good care of whole body vim and vigour; Four compatibilities, treating blood disorders, blood stasis dispelling, except stagnant effect brings out the best in each other.It is supporing yang that Cortex Cinnamomi is mended fire, dispersing cold for relieving pain, promoting blood circulation to restore menstrual flow; The Pericarpium Zanthoxyli acrid in the mouth is warm in nature, and the analgesia thromboembolism preventing, prevent platelet aggregation; Radix Salviae Miltiorrhizae circulation of qi promoting dissipating blood stasis, detumescence is except stagnant; All medicines coordinates, warming YANG, cold expelling, pain relieving, invigorate blood circulation, the dissipating blood stasis effect is better.The Rhizoma Alpiniae Officinarum warming spleen and stomach for dispelling cold, promoting the circulation of QI to relieve pain; The Rhizoma Cyperi dispelling cold by warming the meridian, regulating QI to relieve pain; The Radix Glycyrrhizae relieving spasm to stop pain, auxiliary healthy energy; Three medicines share, regulating QI to relieve pain, and relief of symptoms is more quick.The party's combination, warming YANG is capable stagnant, the righting of regulating the flow of vital energy, blood circulation promoting and blood stasis dispelling, detumescence is except piece, and all medicines coordinate the basic principle that meets traditional Chinese medical science prescription fully.
Moreover, the pharmacological action of said medicine, all have relevant single medicine pharmacological research and animal experiment conclusion to confirm.
Medicine of the present invention can adopt the conventional method of Chinese medicine preparation to make any dosage form for oral administration.
Medicine of the present invention adopts the pharmacy of Chinese materia medica common process to make capsule.
Medicine of the present invention adopts the pharmacy of Chinese materia medica common process to make tablet.
Medicine of the present invention adopts the pharmacy of Chinese materia medica common process to make powder or granule.
Medicine of the present invention adopts the pharmacy of Chinese materia medica common process to make watered pill, honey pill agent, water-honeyed pill, concentrated pill or drop pill.
Medicine of the present invention adopts the pharmacy of Chinese materia medica common process to make oral liquid.
Medicine of the present invention adopts the pharmacy of Chinese materia medica common process to make medicinal tea.
Medicine of the present invention also can adopt the method effective component extractings such as semi-bionic extraction, supercritical fluid extraction, microwave extraction, enzyme engineering technology, ultrasonic extraction, Flavonoids by Macroporous Adsorption Resin, but these extracting modes are all in protection scope of the present invention.
Medicine of the present invention shows that through result in clinical application following advantage is arranged:
1, to select the natural edible-plant medicine be raw material in the present invention, and each component meets Medicine Act regulation and tcm prescription principle, gives prominence to the basic characteristic that Chinese medical discrimination combines with the doctor trained in Western medicine differential diagnosis of diseases, etiological treatment combines with symptomatic treatment;
2, after extract drugs of the present invention, mouthfeel is better, taking convenience, and all nontoxic before and after each herbal medicine prescription, normal dose is taken and is not found toxic and side effects;
3, to dysmenorrhea, endometriosis, ovarian cyst, hysteromyoma, tissue adhesion, gynecological's inflammatory bag be fast etc., disease has good therapeutical effect to medicine of the present invention;
But 4, all selected in the kind of Ministry of Public Health regulation medicine-food two-purpose, safety is higher for medicine of the present invention, but some gynecological chronic disease long periods are taken;
5, medicine treating both the principal and secondary aspects of a disease of the present invention, take effect rapidly, and cure rate is high.
The specific embodiment
Medicine of the present invention is through clinical observation on the therapeutic effect and safety testing, shows for oral administration safe and reliablely, and therapeutic effect is remarkable, has certain promotional value.
Embodiment 1
Semen Persicae 10-45 part, Flos Carthami 10-45 part, Radix Paeoniae Alba 10-40 part, Radix Angelicae Sinensis 10-50 part, Radix Salviae Miltiorrhizae 10-45 part, Cortex Cinnamomi 10-45 part, Pericarpium Zanthoxyli 10-36 part, Rhizoma Alpiniae Officinarum 10-45 part, Radix Glycyrrhizae 10-36 part, Rhizoma Cyperi 10-45 part.
Adopt the preparation method of conventional Chinese medicine, make every containing the capsule that extracts medicated powder 0.45 gram.
Clinical experiment example 1: endometriosis dysmenorrhea
Physical data
Observe dysmenorrhea patient totally 122 examples.Be divided at random observation group and matched group.Two groups of patients are from outpatient service, the course of disease 3 months to 4 years 9 months.Observation group's ages 61 example, age 19-39 year; Matched group 61 examples, the age is 19-38 year.The degree of observation group's dysmenorrhea is slight person's 6 examples, moderate 20 examples, severe 35 examples; The degree of matched group dysmenorrhea is slight person's 5 examples, moderate 22 examples, severe 34 examples.Learn and process there was no significant difference between the two by statistics.
Diagnosis of Endometriosis standard: " new Chinese medicine guideline of clinical investigations " endometriosis and the dysmenorrhea diagnostic criteria of issuing with reference to Ministry of Public Health: (1) progressive dysmenorrhea; (2) lack abdomen, waist sacrum discomfort, the aggravation of carrying out property menstrual period; (3) periodicity rectal distention stimulation symptom, the aggravation of carrying out property; (4) posterior fornix jarjavay's ligaments or isthmus uteri contact painful tubercles; (5) adnexa adhesion enclosed mass companion peplos tuberosity sense, tubal patency; (6) the adnexa enclosed mass is little before and after menstruation a significant change.All have in above (1)-(3) in 1 and (4)-(6) 1, seron Endometrium antibody positive, and CA-125 abnormal (can be for referencial use between 25-35), get final product diagnosis of endometriosis.
The standard of dysmenorrhea light and heavy degree: menstrual period or its front and back lower abdomen pain are obvious, and companion's waist is ached, but can adhere to work, without General Symptoms, sometimes need to take analgesic for slight; Menstrual period or its front and back lower abdomen hurt like hell, companion's waist is ached, nausea and vomiting, extremity are not warm, and by pain relieving measure pain, postponing is moderate; Menstrual period or its front and back lower abdomen hurt like hell, feel restless, and has a strong impact on work and study and daily life, must lie up, companion's waist is ached, pale complexion, dripping cold sweat, extreme cold of the limbs, vomiting and diarrhoea, or rectal tenesmus, adopt the pain relieving measure without obviously alleviating as severe.
Therapeutic Method
Medicament capsule of the present invention is taken by observation group, and every day 3 times, each 4 (every contains extraction medicated powder 0.45 gram, lower same), premenstrual 1 day starts to take, and takes continuously afterwards always, within 3 months, is 1 course for the treatment of.
Matched group is taken danazol capsule 200mg * 30 (Hualian Pharmaceutical Co., Shanghai, lot number is 20020130), each 200mg; every day 2 times is oral, and menstruation starts to take medicine on the 5th day, after amenorrhea occurring; dosage is reduced to 200mg every day, is maintenance dose, and treating continuously 3 months is 1 course for the treatment of.
Two groups are all finished rear 3 menstrual cycle and follow up a case by regular visits to the statistics curative effect in treatment 1 course for the treatment of.
Therapeutic effect
Criterion of therapeutical effect: " traditional Chinese medical science disease Standardization of diagnosis and curative effect " according to State Administration of Traditional Chinese Medicine, issued drafted.Cure: pain disappears, and continuous 3 menstrual cycle do not recur; Take a turn for the better: pain relief or disappearance, but can not maintain 3 menstrual cycle; Invalid: pain has no improvement.
Statistical method: application SPSS13.0 statistics software, calculating chart with
mean, relatively check with user documents (shipped with equipment) t between group, the enumeration data chi-square criterion, there is statistical significance P<0.05 for difference.
Interpretation of result
Treatment group 61 examples, cure 37 examples, 21 examples that take a turn for the better, and invalid 3 examples, total effective rate is 95.1%.
Matched group is cured 19 examples, 26 examples that take a turn for the better, and invalid 16 examples, total effective rate is 73.8%.
Learn and process by statistics, two groups have significant difference (P<0.05), and treatment group is better than matched group.
Moreover, the improvement for the treatment of group symptom of other except dysmenorrhea (as menoxenia, infertile, pelvic lump, sexual anhedonia etc.) to the patient, also apparently higher than matched group.
Clinical experiment example 2: ovarian cyst
Physical data
Observe ovarian cyst (functional cyst, hemorrhagic cyst, endometrioid cyst and malignant tumor of ovary, teratoma is not within this range of observation) patient 77 examples, wherein chocolate cyst of ovary 56 examples, serosity and mucus epidermal cyst 21 examples.Above-mentioned case is all determined the size of ovarian cyst through color ultrasound.Patient age is 23-42 year, and the course of disease is 1 month-22 months.Once Drug therapy person's 33 examples, not therapist 44 examples.
Therapeutic Method
The patient takes medicament capsule of the present invention, every day 3 times, each 4.Taking 3 months was 1 course for the treatment of, full 1 course for the treatment of of B ultrasonic check again.
Therapeutic outcome
Criterion of therapeutical effect: after medication, ovarian cyst disappears, and after 1 month, following up a case by regular visits to without recurrence is clinical cure; Ovarian cyst volume-diminished to 50% is above is produce effects; Ovarian cyst volume-diminished 10% is to 50% being effective; Ovarian cyst is dwindled below 10%, front and back are invalid without change or increase person.
Interpretation of result: after treating 1 course for the treatment of, cure 28 examples in this group example, produce effects 29 examples, effective 16 examples, invalid 4 examples, total effective rate is 94.8%.
Clinical experiment example 3: hysteromyoma
Physical data
Observe and select intramural myoma case 96 examples, wherein multiple myomata 29 examples.All cases are all determined the size of hysteromyoma before and after treatment through color ultrasound.Patient age is 26-41 year, and the course of disease is 1 month-32 months.Once Drug therapy person's 39 examples, not therapist 57 examples.
Therapeutic Method
All patients take medicament capsule of the present invention, every day 3 times, each 4.Taking 3 months was 1 course for the treatment of, full 1 course for the treatment of of B ultrasonic check again.
Therapeutic outcome
Criterion of therapeutical effect: after medication, hysteromyoma disappears, and in drug withdrawal, after 1 month, following up a case by regular visits to without recurrence is clinical cure; After treatment, more than hysteromyoma volume-diminished to 50%, be produce effects; After treatment, hysteromyoma volume-diminished 10% is to 50% being effective; The hysteromyoma volume-diminished below 10% or after treatment hysteromyoma increase person is arranged for invalid.For multiple myomata, with each hysteromyoma volume sum, added up.
Interpretation of result: after treating 1 course for the treatment of, cure 29 examples in this group case, produce effects 39 examples, effective 18 examples, invalid 10 examples, total effective rate is 89.6%.
Clinical experiment example 4: safety testing
Test method
The test crowd: in order to observe this medicine, the normal human is had to avirulence, we select 40 examples (average 32 ± 6.2 years old of age) healthy premenopausal volunteers (except gestation or women breast-feeding their children), adopt self cross-reference form.
Instructions of taking: every day 3 times, each 4-6 grain, every 0.45 gram, one after each meal, continuous 3 weeks.Medicament capsule is provided by Jiangsu Yi Hai Pharmaceutical Co.
Observation index
The safety observation index mainly comprises total protein TP, albumin A LB, darling renal function (glutamic oxaloacetic transaminase, GOT AST, glutamate pyruvate transaminase ALT, blood urea nitrogen BUN, inosine CRE), blood glucose GLU, blood fat (T-CHOL TC, triglyceride TG, HDL-C HDL-C), Hb H GB, erythrocyte RBC, leukocyte WBC, urinate ten.
Result of the test
Tested volunteer fore-and-aft observing achievement data is learned by statistics and is processed there was no significant difference (P>0.05).
Observed result for details see attached table.
Subordinate list safety indexes detection case
Claims (8)
1. the medicine of a fast treating dysmenorrhea and abdominal mass is characterized in that it is that material medicine by following weight parts is prepared from:
Semen Persicae 6-60 part Flos Carthami 6-60 part Radix Paeoniae Alba 6-45 part Radix Angelicae Sinensis 6-60 part
Radix Salviae Miltiorrhizae 3-60 part Cortex Cinnamomi 6-60 part Pericarpium Zanthoxyli 3-45 part Rhizoma Alpiniae Officinarum 6-60 part
Radix Glycyrrhizae 3-45 part Rhizoma Cyperi 6-60 part.
2. the medicine of a kind of fast treating dysmenorrhea and abdominal mass as claimed in claim 1, it is characterized in that: the preferred deal ratio of described material medicine is:
Semen Persicae 10-45 part Flos Carthami 10-45 part Radix Paeoniae Alba 10-40 part Radix Angelicae Sinensis 10-50 part
Radix Salviae Miltiorrhizae 10-45 part Cortex Cinnamomi 10-45 part Pericarpium Zanthoxyli 10-36 part Rhizoma Alpiniae Officinarum 10-45 part
Radix Glycyrrhizae 10-36 part Rhizoma Cyperi 10-45 part.
3. the medicine of a kind of fast treating dysmenorrhea and abdominal mass as claimed in claim 1, is characterized in that adopting the pharmacy of Chinese materia medica common process to make capsule.
4. the medicine of a kind of fast treating dysmenorrhea and abdominal mass as claimed in claim 1, is characterized in that adopting the pharmacy of Chinese materia medica common process to make tablet.
5. the medicine of a kind of fast treating dysmenorrhea and abdominal mass as claimed in claim 1, is characterized in that adopting the pharmacy of Chinese materia medica common process to make powder or granule.
6. the medicine of a kind of fast treating dysmenorrhea and abdominal mass as claimed in claim 1, is characterized in that adopting the pharmacy of Chinese materia medica common process to make watered pill, honey pill agent, water-honeyed pill, concentrated pill or drop pill.
7. the medicine of a kind of fast treating dysmenorrhea and abdominal mass as claimed in claim 1, is characterized in that adopting the pharmacy of Chinese materia medica common process to make oral liquid.
8. the medicine of a kind of fast treating dysmenorrhea and abdominal mass as claimed in claim 1, is characterized in that adopting the pharmacy of Chinese materia medica common process to make medicinal tea.
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| CN201210215667.4A CN102727808B (en) | 2012-06-27 | 2012-06-27 | Drugs to quickly treat menstrual cramps and abdominal lumps |
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| CN1265824C (en) * | 2002-07-31 | 2006-07-26 | 顾海铮 | Chinese medicinal preparation for treating dysmenorrhea and preparation method thereof |
| CN101366892A (en) * | 2008-09-03 | 2009-02-18 | 李富祥 | Chinese medicinal composition for treating menorrhalgia |
| CN102228591B (en) * | 2011-06-23 | 2012-08-29 | 贵州弘康药业有限公司 | Preparation method of oral medicinal preparation for regulating menstruation and stopping pains |
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