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CN102727192A - Pulmonary circulation blood pressure monitoring equipment based on body surface phonocardiogram and method for monitoring pulmonary circulation blood pressure by using equipment - Google Patents

Pulmonary circulation blood pressure monitoring equipment based on body surface phonocardiogram and method for monitoring pulmonary circulation blood pressure by using equipment Download PDF

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Publication number
CN102727192A
CN102727192A CN2012102087814A CN201210208781A CN102727192A CN 102727192 A CN102727192 A CN 102727192A CN 2012102087814 A CN2012102087814 A CN 2012102087814A CN 201210208781 A CN201210208781 A CN 201210208781A CN 102727192 A CN102727192 A CN 102727192A
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blood pressure
pulmonary circulation
circulation blood
monitoring
equipment
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CN102727192B (en
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唐洪
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Dalian University of Technology
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Dalian University of Technology
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Abstract

The invention discloses a method and a device for monitoring the pulmonary circulation blood pressure based on body surface phonocardiogram signals. In monitoring, the mechanical closing time of cardiac valves is used as an input parameter; and the parameters are periodically detected, and the change trend of the pulmonary circulation blood pressure is calculated according to the change trend of the parameters, so the noninvasive pulmonary circulation blood pressure is realized. Because the physiological relationship of the mechanical closing time of cardiac valves and pulmonary circulation blood stream dynamics are utilized in the method, the relative change trend of the pulmonary circulation blood pressure can be monitored under an uncalibrated condition. The equipment for monitoring the pulmonary circulation blood pressure is noninvasive, easy to operate, and low in cost.

Description

一种基于体表心音的肺循环血压监测设备和方法A device and method for monitoring pulmonary circulation blood pressure based on body surface heart sounds

技术领域 technical field

本项目属于医疗器械领域,涉及一种肺循环血压的无创监测仪器,是一种基于体表心音无创监测肺循环血流动力,特别是利用体表心音信号中蕴藏的瓣膜关闭时间来监测受试者的肺循环血压,实现无创的方式连续监测肺循环血压的仪器。  This project belongs to the field of medical devices and involves a non-invasive monitoring instrument for pulmonary blood pressure. It is a non-invasive monitoring of pulmonary circulation hemodynamics based on body surface heart sounds, especially using the valve closing time contained in body surface heart sound signals to monitor subjects. Pulmonary blood pressure, an instrument for continuous monitoring of pulmonary blood pressure in a non-invasive manner. the

背景技术 Background technique

现有的肺循环血压监测一般以有创的右心导管术测量肺循环血压,这是一种“事后”的检测手段,不适于对肺循环高血压的早期筛查。目前常见的无创肺循环血压测量方法是超声多普勒法,但只能用于受试者伴有三尖瓣返流的情况,而且对操作者的技巧要求较高,应用有较大的局限性。  Existing monitoring of pulmonary circulation blood pressure generally uses invasive right heart catheterization to measure pulmonary circulation blood pressure, which is a "post-event" detection method and is not suitable for early screening of pulmonary circulation hypertension. At present, the common non-invasive pulmonary circulation blood pressure measurement method is ultrasonic Doppler method, but it can only be used in the case of subjects with tricuspid regurgitation, and it requires high skill of the operator, so the application has great limitations. the

发明内容 Contents of the invention

本发明针对现有技术中存在的问题,提供了一种无创的、连续的、操作简便的肺循环血压监测方法和仪器。可用于定期体检中早期筛查肺循环血流动力相关疾病,或用于监测可疑患者的病情发展过程,或用于评估疾病的治疗效果。  The invention aims at the problems existing in the prior art and provides a non-invasive, continuous and easy-to-operate pulmonary circulation blood pressure monitoring method and instrument. It can be used for early screening of diseases related to pulmonary circulation and hemodynamics during regular physical examination, or for monitoring the disease progression of suspicious patients, or for evaluating the treatment effect of diseases. the

一种基于体表心音的肺循环血压监测设备,包括如下组成部分:  A device for monitoring pulmonary circulation blood pressure based on body surface heart sounds, comprising the following components:

心音传感器,所述的心音传感器单元用于获取受试者的心音信号,其能够将心脏瓣膜的振动转化为电信号;  Heart sound sensor, the heart sound sensor unit is used to obtain the subject's heart sound signal, which can convert the vibration of the heart valve into an electrical signal;

前端模块,所述的前端模块与心音传感器单元相连,用于对所述的心音信号进行放大、滤波、数模转换;  A front-end module, the front-end module is connected to the heart sound sensor unit for amplifying, filtering, and digital-to-analog conversion of the heart sound signal;

数据处理器,所述的数据处理器特征提取模块,与前端模块相连,用于分析心音信号,提取时间特征参数,并根据特征参数的变化趋势估计肺循环血压的变化趋势;  Data processor, the data processor feature extraction module is connected with the front-end module for analyzing the heart sound signal, extracting time characteristic parameters, and estimating the variation trend of pulmonary circulation blood pressure according to the variation trend of the characteristic parameters;

存储模块,所述的存储模块与数据处理器相连,用于存储两方面内容:一是用于存储前期和当前获得的心音特征参数,二是用于存储心音特征参数与肺循环血压的生理关系。存储模块为只读存储器或可重写存储器。  The storage module is connected with the data processor and is used to store two aspects: one is used to store the heart sound characteristic parameters acquired earlier and currently, and the other is used to store the physiological relationship between the heart sound characteristic parameters and pulmonary circulation blood pressure. The storage module is a read-only memory or a rewritable memory. the

显示模块,所述的显示模块与数据处理器相连,用于显示肺循环血压的变化趋势。  A display module, the display module is connected with the data processor and is used to display the variation trend of the pulmonary circulation blood pressure. the

上述的设备,还包括键盘输入模块,所述的键盘输入模块,与数据处理器相连,用于系统参数的设定,或在标定时用于输入标定参数。  The above-mentioned device also includes a keyboard input module, the keyboard input module is connected with the data processor, and is used for setting system parameters, or for inputting calibration parameters during calibration. the

上述的设备,还包括一个外套,用于固定和安装所述设备。  The above-mentioned device also includes a jacket for fixing and installing the device. the

为了达到上述目的,本发明提供了基于体表心音的无创肺循环血压监测方法,包括以下步骤:  In order to achieve the above object, the present invention provides a non-invasive pulmonary circulation blood pressure monitoring method based on body surface heart sounds, comprising the following steps:

1)从受试者身上采集心音信号;  1) Collect heart sound signals from the subjects;

2)从采集的心音信号中提取表示瓣膜关闭的多个时间差信息,存储备用;  2) Extract multiple time difference information indicating valve closure from the collected heart sound signals, and store them for later use;

3)间隔一段时间后,采集同一受试者的心音信号;  3) After a period of time, collect the heart sound signal of the same subject;

4)如所述步骤2),提取表示瓣膜关闭的多个时间差信息,存储备用;  4) As described in step 2), extract multiple time difference information indicating valve closure and store them for future use;

5)通过分析所述时间差的变化趋势,给出肺循环血压的变化趋势结论:“升高”、“保持”或“降低”;  5) By analyzing the change trend of the time difference, give the conclusion of the change trend of pulmonary circulation blood pressure: "increase", "maintain" or "decrease";

6)在定期体检中记录所述的时间差,可监测受试者的肺循环血压变化情况。  6) Record the time difference in the regular physical examination to monitor the change of the subject's pulmonary circulation blood pressure. the

所述的步骤3)中间隔一段时间,采集同一受试者的心音信号。  The heart sound signal of the same subject is collected at intervals in the step 3). the

所述步骤中还包括时间参数的统计平均值。  The step also includes a statistical average of time parameters. the

所述的步骤5)给出的肺循环血压变化趋势,可以是右心室收缩压、平均压的变化趋势。  The variation trend of the pulmonary circulation blood pressure given in step 5) may be the variation trend of right ventricular systolic pressure and mean pressure. the

本发明涉及的特征参数是心音中表示瓣膜关闭的多个时间差信息。这些参数可以是多次测量的统计平均值。本发明可监测肺循环右心室收缩压、平均压 的变换趋势。  The characteristic parameter involved in the present invention is a plurality of time difference information representing valve closing in the heart sound. These parameters can be statistical averages of multiple measurements. The present invention can monitor the change trend of pulmonary circulation right ventricle systolic pressure and mean pressure. the

本发明提供的无创肺循环血压可应用于定期体检中,从而实现连续地、实时地监测肺循环血压,可形成受试者的长期肺循环血压历史记录,以便医护人员对受试者进行综合判断。  The non-invasive pulmonary circulation blood pressure provided by the present invention can be applied to regular physical examinations, so as to realize continuous and real-time monitoring of pulmonary circulation blood pressure, and can form a long-term historical record of pulmonary circulation blood pressure of subjects, so that medical staff can make comprehensive judgments on subjects. the

说明书附图  Attached to the manual

图1用于说明本发明方法的操作示意图;  Fig. 1 is used to illustrate the operation schematic diagram of the inventive method;

图2用于说明心音中表示瓣膜关闭时间差的特征参数;  Figure 2 is used to illustrate the characteristic parameters representing the valve closing time difference in heart sounds;

图3用于说明本发明的工作流程;  Fig. 3 is used for illustrating the workflow of the present invention;

图4为本发明所述的肺循环血压监测仪器的结构示意图。  Fig. 4 is a schematic structural diagram of a pulmonary circulation blood pressure monitoring instrument according to the present invention. the

图中:410心音传感器;420前端模块;430键盘输入模块;440数据处理器;450存储模块;460显示模块。  In the figure: 410 heart sound sensor; 420 front-end module; 430 keyboard input module; 440 data processor; 450 storage module; 460 display module. the

具体实施方式 Detailed ways

参考图3对本发明的实施进行具体说明。鉴于本发明是以多次测量心音特征参数监测肺循环血压的相对变化趋势,对于第一次采集心音信号的受试者不能给出分析结论。如果受试者已经完成多次(包括两次)数据采集310,则读入以前的数据320,并显示以前的分析结论330。受试者处于静息状态,以仰卧姿态,每次采集心音信号3-5分钟340,提取每个心动周期内瓣膜的关闭时间差作为心音特征350,并将这些数据保存360,以备将来使用。为了消除各种随机因素的影响,需对心音特征进行统计平均处理370。从存储器中读入瓣膜关闭时间与肺循环血流动力的关系380,并结合心音特征在前后的变化趋势,经过分析与处理390,得出肺循环血压变化趋势的结论391,并显示出来。  The implementation of the present invention will be specifically described with reference to FIG. 3 . In view of the fact that the present invention monitors the relative change trend of the pulmonary circulation blood pressure by measuring the heart sound characteristic parameters multiple times, no analysis conclusion can be given for the subject whose heart sound signal is collected for the first time. If the subject has completed multiple (including two) data collection 310 , then read in the previous data 320 and display the previous analysis conclusion 330 . The subject is in a resting state, in a supine position, collects heart sound signals for 3-5 minutes each time 340, extracts the valve closing time difference in each cardiac cycle as heart sound features 350, and saves these data 360 for future use. In order to eliminate the influence of various random factors, it is necessary to perform statistical average processing 370 on the characteristics of the heart sound. Read the relationship 380 between valve closing time and pulmonary circulation hemodynamics from the memory, and combine the change trend of heart sound characteristics before and after, analyze and process 390, draw the conclusion 391 of the change trend of pulmonary blood pressure, and display it. the

如图所示,心音传感器410用于将瓣膜振动转换为电信号,并由前端模块 420进行放大、滤波。由数据处理模块440对心音电信号进行采集并完成心音特征提取工作。键盘输入模块430完成输入心音特征与肺循环血流动力的关系或标定参数。存储模块450用于存储心音特征与肺循环血流动力的关系、前期心音特征、前期结论以及本次心音特征、本次分析结论等。显示模块460用于显示心音特征的长期变化趋势以及分析出的肺循环血压变化趋势。  As shown in the figure, the heart sound sensor 410 is used to convert the valve vibration into an electrical signal, which is amplified and filtered by the front-end module 420. The data processing module 440 collects the heart sound electrical signal and completes the heart sound feature extraction work. The keyboard input module 430 completes the input of the relationship or calibration parameters between the heart sound characteristics and pulmonary circulation hemodynamics. The storage module 450 is used to store the relationship between heart sound characteristics and pulmonary circulation hemodynamics, previous heart sound characteristics, previous conclusions, current heart sound characteristics, and current analysis conclusions. The display module 460 is used for displaying the long-term change trend of heart sound characteristics and the analyzed change trend of pulmonary circulation blood pressure. the

Claims (9)

1. the pulmonary circulation monitoring of blood pressure equipment based on the body surface hear sounds is characterized in that, comprising:
Heart sound transducer, described heart sound transducer is used to obtain experimenter's cardiechema signals, and it can be converted into the signal of telecommunication with valvular vibration;
Front-end module, described front-end module links to each other with the heart sound transducer unit, be used for to described cardiechema signals amplify, filtering, digital-to-analogue conversion;
Memory module, described memory module links to each other with data processor, is used to store two aspect contents: the one, be used to store early stage and the hear sounds characteristic parameter that obtains, the 2nd, be used to store the physiological relation of hear sounds characteristic parameter and pulmonary circulation blood pressure.
Data processor, described data processor characteristic extracting module links to each other with front-end module, is used to analyze cardiechema signals, extraction time characteristic parameter, and estimate the variation tendency of pulmonary circulation blood pressure according to the variation tendency of characteristic parameter;
Display module, described display module links to each other with data processor, is used to show the variation tendency of pulmonary circulation blood pressure.
2. equipment as claimed in claim 1 is characterized in that, said heart sound transducer unit is made up of pick off or resistance or non-linear element.
3. equipment as claimed in claim 1 is characterized in that, also comprises the keyboard input module, and described keyboard input module links to each other with data processor, is used for the setting of systematic parameter, or is used for the input calibration parameter at timing signal.
4. equipment as claimed in claim 1 is characterized in that, memory module is read only memory or recordable memory.
5. like the arbitrary described equipment of claim 1, it is characterized in that, also comprise an overcoat, be used for fixing and said equipment is installed.
6. the pulmonary circulation monitoring of blood pressure method of the arbitrary described equipment of claim 1-5, its characteristic may further comprise the steps:
1) gathers cardiechema signals on one's body from the experimenter;
2) from the cardiechema signals of gathering, extract a plurality of time difference informations that the expression valve is closed, store subsequent use;
3) behind the certain interval of time, gather same experimenter's cardiechema signals;
4) like said step 2), extract a plurality of time difference informations that the expression valve is closed, store subsequent use;
5) through analyzing the variation tendency of said time difference, provide the variation tendency conclusion of pulmonary circulation blood pressure: " rising ", " maintenance " or " reduction ";
6) in having regular physical checkups, write down described time difference, can monitor experimenter's pulmonary circulation blood pressure situation.
7. pulmonary circulation monitoring of blood pressure method as claimed in claim 6 is characterized in that, said step 3) interval a period of time, gathers same experimenter's cardiechema signals.
8. like claim 6 or 7 described pulmonary circulation monitoring of blood pressure methods, it is characterized in that, also comprise the assembly average of time parameter in the said step.
9. like claim 6 or 7 arbitrary described pulmonary circulation monitoring of blood pressure methods, it is characterized in that the pulmonary circulation blood pressure trend that said step 5) provides can be the variation tendency of right ventricular systolic pressure, mean pressure.
CN201210208781.4A 2012-06-21 2012-06-21 Pulmonary circulation blood pressure monitoring equipment based on body surface phonocardiogram and method for monitoring pulmonary circulation blood pressure by using equipment Expired - Fee Related CN102727192B (en)

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