CN102716281B - Care solution for cleaning wounds after operation - Google Patents
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- CN102716281B CN102716281B CN201210242884.2A CN201210242884A CN102716281B CN 102716281 B CN102716281 B CN 102716281B CN 201210242884 A CN201210242884 A CN 201210242884A CN 102716281 B CN102716281 B CN 102716281B
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Abstract
The invention discloses a care solution for cleaning wounds after operation, and relates to the technical field of traditional Chinese medicines. The care solution is prepared from the following traditional Chinese medicines in parts by weight: 10-14 parts of dragon bone, 5-8 parts of cinnabar, 15-20 parts of frankincense, 15-20 parts of myrrh, 15-20 parts of radix angelicae, 12-18 parts of rush and 2-3 parts of dried alum. The care solution for cleaning wounds after operation disclosed by the invention has the functions of resisting bacteria, forming film, promoting granulation growth, easing pain and the like, and can improve the fibroblast content in the granulation tissue of wounds to effectively promote wound healing.
Description
Technical field
The present invention relates to the Chinese medicine technical field, be specifically related to a kind of conditioning liquid cleaned for postoperative wound.
Background technology
Skin is health and the extraneous first barrier contacted, and can stop the intrusion of antibacterial, virus etc.But, when the skin Shi，Zhe road barrier that sustains damage also has been broken, the people knows from experience the infringement that is subject to antibacterial, virus.The domestic main medicine for the skin degerming debridement has medical alcohol, liquor iodi mitis, povidone iodine, furacilin solution, bromogeramine solution etc. at present, yet clinical practice finds that the zest that these medicines have is too strong, can not large-area applications, some clinical debridement effects are undesirable, and anaphylaxis is even arranged.In addition, these medicines all do not promote the functions such as granulation growth and analgesia.
The processing method of the traumatic wounds that modern doctor trained in Western medicine surgery causes operation is that, to wound sterilizing, sterilization, the application antibiotic is protected from infection, the method for wrapping up with hospital gauze after sew up wound.Stitching has closure of wound, promotes hemostasis and organization healing effect, be the most basic technology of modern surgery, so manual suture is current most widely used method.In addition, not medication on wound of modern surgery, the healing of wound is to repair by the tissue of body self.General 2-3 days after surgery, the patient changes a dressing, and purpose is to be to observe and clean wound.As can be seen here, doctor trained in Western medicine relies on patient's tissue repairing ability itself fully for the healing of postoperative wound, and wound healing is slow, and has increased patient infection's risk.
Summary of the invention
The object of the present invention is to provide a kind of conditioning liquid cleaned for postoperative wound.The functions such as that wound care liquid of the present invention has is antibiotic, conjunctiva, the growth of promotion granulation and analgesia, infect and promote in control and have unique effect aspect wound healing.
The object of the present invention is achieved like this:
A kind of conditioning liquid cleaned for postoperative wound, be prepared from by the Chinese crude drug of following weight portion: Os Draconis 10-14 part, Cinnabaris 5-8 part, Olibanum 15-20 part, Myrrha 15-20 part, Radix Angelicae Dahuricae 15-20 part, Medulla Junci 12-18 part, dried Alumen 2-3 part.
Preferably, the described conditioning liquid cleaned for postoperative wound, be prepared from by the Chinese crude drug of following weight portion: 12 parts of Os Draconis, 6 parts, Cinnabaris, 18 parts of Olibanums, 18 parts of Myrrhas, 18 parts of the Radixs Angelicae Dahuricae, 15 parts of Medulla Juncies, 2 parts of dried Alumens.
Further preferably, the described conditioning liquid cleaned for postoperative wound is lotion.
The preparation method of the conditioning liquid cleaned for postoperative wound the present invention relates to comprises the steps: to take Os Draconis, Cinnabaris, Olibanum, Myrrha, the Radix Angelicae Dahuricae, Medulla Junci, dried Alumen, clean roguing, dry, be ground into granule, with bundle it, put in people's container, add 20-25 times of water, soak after 20-30 minute and decoct about 25-40 minute, filter medicinal residues and obtain filtrate, stirring and dissolving, be sub-packed in the bottle of 100ml, and gland is also standby in 115 ℃ of high temperature sterilize 30-60min.
Using method: when conditioning liquid is heated to 30-40 ℃, cleans a wound repeatedly with gauze or sponge libation at an ancient wedding ceremony taking liquid, or make wound directly soak into the liquid 30-45 minute, every day 3-4 time, but every dose of medicine Reusability 1 day, 7 days was 1 course for the treatment of.
According to the Chinese medicine Historical Data Data About, the pharmacologically active of above-mentioned Chinese crude drug is as follows:
Os Draconis: tranquillizing the mind by relieving convulsion, arresting sweating controlling nocturnal emission with astringent drugs, hemostasis astringing intestine to stop diarrhea, promoting tissue regeneration and ulcer healing.Be used for the treatment of infantile convulsion demented, palpitation with a distress feeling is forgetful, insomnia and dreamful sleep, and spontaneous sweating, the seminal emission stranguria with turbid discharge, bleeding not during menses, the dysentery proctoptosis, ulcer does not close up for a long time.Derive from the ancient times mammals as if the fossil of the skeleton of class, rhinoceros class, Hippocampal cortex etc.
Cinnabaris: clear away heart-fire relieving convulsion, the removing toxic substances of calming the nerves, for palpitation and being susceptible to fright, insomnia and dreamful sleep, epilepsy is gone mad, infantile convulsion, blurring of vision, aphtha, sore throat.Cinnabaris is mercury compound class mineral cinnabar family cinnabar, main Containing Sulfur hydrargyrum.
Olibanum: have regulating qi and activating blood, analgesic therapy, chase after malicious effect.For regulating qi and activating blood, analgesic therapy, chase after poison.Control coagulation of QI-blood, trusted subordinate's pain, carbuncle pyogenic infections from tumour or sore, traumatic injury, dysmenorrhea, postnatal blood stasis twinge.The smoked Lu Xiang of another name.Select the gum resin of olive subject plant Boswellia carterii Birdw (Baswellia carterii Birdw.).
Myrrha: have promoting blood circulation and stopping pain is arranged, the effect such as detumescence and promoting granulation.Cure mainly breast abdomen stasis of blood pain, dysmenorrhea, amenorrhea, lump in the abdomen, traumatic injury, carbuncle skin infection, acute appendicitis, conjunctival congestion and swelling pain.Select the dry resin of olive subject plant Herba Violae tree or Ha Didingshu, have another name called myrrh.
The Radix Angelicae Dahuricae: wind-damp dispelling, the evacuation of pus of invigorating blood circulation, granulation promoting pain relieving.For headache, toothache, nasal sinusitis, hemorrhoidal hamorrhage anal fistula, leucorrhea with red and white discharge, ulcer sores, skin pruritus.Select the root of samphire angelica anomala.
Medulla Junci: relieving stranguria by diuresis, clearing heart fire.Cure mainly gonorrhea, edema, dysuria, the puckery pain of oliguria, jaundice due to damp-heat, dysphoria and insomnia, the nocturnal fretfulness in infants, sore throat, aphtha of the mouth and tongue, wound.Select the stem pith of rush family plant Medulla Junci.
Dried Alumen: expectorant, dampness, antidiarrheal, hemostasis, removing toxic substances, parasite killing.Control epilepsy, sore throat, hepatitis, jaundice, general edema with yellowish skin, Stomach duodenum ulcer, uterine prolapse, leucorrhea, dysentery, aphtha of the mouth and tongue, skin ulcer hemorrhoid scabies.
The functions such as that wound care liquid of the present invention has is antibiotic, conjunctiva, the growth of promotion granulation and analgesia, infect and promote in control and have unique effect aspect wound healing.In clinical observation, wound care liquid of the present invention has than positive effect for wound healing, can, every bacterium, antibacterial promotion wound healing, can prevent again and the wound adhesion, to newborn skin and wound without secondary damage, use the consistent reflection of rear patient of changing dressings of wound care liquid to feel comfortable, without pain, stimulate little to wound, clearly, the wound surface exudate obviously reduces, and wound surface does not give an offensive smell, abnormal smells from the patient delicate fragrance.Study discovery by animal experiment, can find out according to the result of the test of table 1 and table 2, As time goes on, the conditioning liquid group is compared with matched group, aspect rat wound surface CI or fibroblast number, have significant difference (
p<0.05), even utmost point significant difference (
p<0.01), this illustrates that wound surface conditioning liquid of the present invention can improve the content of wound surface Granulation tissue fibroblasts, thus quick wound healing effectively.
The specific embodiment
Be below specific embodiments of the invention, technical scheme of the present invention is done to further the description, but protection scope of the present invention is not limited to these embodiment.Every do not deviate from the change of the present invention design or be equal to substitute include within protection scope of the present invention.
Embodiment 1
Prescription: 12 parts of Os Draconis, 6 parts, Cinnabaris, 18 parts of Olibanums, 18 parts of Myrrhas, 18 parts of the Radixs Angelicae Dahuricae, 15 parts of Medulla Juncies, 2 parts of dried Alumens.
Preparation method: take Os Draconis, Cinnabaris, Olibanum, Myrrha, the Radix Angelicae Dahuricae, Medulla Junci, dried Alumen, clean roguing, dry, be ground into granule, with bundle it, put in people's container, add 25 times of water, soak after 30 minutes and decoct approximately 30 minutes, filter medicinal residues and obtain filtrate, be sub-packed in the bottle of 100ml, gland is also standby in 115 ℃ of high temperature sterilize 30min.
Embodiment 2
Prescription: 10 parts of Os Draconis, 6 parts, Cinnabaris, 20 parts of Olibanums, 20 parts of Myrrhas, 15 parts of the Radixs Angelicae Dahuricae, 18 parts of Medulla Juncies, 3 parts of dried Alumens.
Preparation method: take Os Draconis, Cinnabaris, Olibanum, Myrrha, the Radix Angelicae Dahuricae, Medulla Junci, dried Alumen, clean roguing, dry, be ground into granule, with bundle it, put in people's container, add 25 times of water, soak after 20 minutes and decoct approximately 40 minutes, filter medicinal residues and obtain filtrate, be sub-packed in the bottle of 100ml, gland is also standby in 115 ℃ of high temperature sterilize 30min.
Embodiment 3
Prescription: 14 parts of Os Draconis, 5 parts, Cinnabaris, 15 parts of Olibanums, 15 parts of Myrrhas, 20 parts of the Radixs Angelicae Dahuricae, 12 parts of Medulla Juncies, 2 parts of dried Alumens.
Preparation method: take Os Draconis, Cinnabaris, Olibanum, Myrrha, the Radix Angelicae Dahuricae, Medulla Junci, dried Alumen, clean roguing, dry, be ground into granule, with bundle it, put in people's container, add 25 times of water, soak after 30 minutes and decoct approximately 25 minutes, filter medicinal residues and obtain filtrate, be sub-packed in the bottle of 100ml, gland is also standby in 115 ℃ of high temperature sterilize 30min.
Embodiment 4 conditioning liquid of the present invention promotes the experimentation of the postoperative rat model wound healing of perianal abscess
64 of SPF level Wistar rats, male and female half and half, weight 220 ± 20g, with 1% ketalar (3mL/kg) intraperitoneal injection of anesthesia.Local preserved skin, routine disinfection, 1 of the circular incision that rat back cut-off footpath is 1cm, cut off skin holostrome, subcutaneous superficial fascia until the flesh layer, after hemostasis, on wound surface, with liquid manure 1mL, (normal person's fresh excreta 10g, add normal saline 5mL, mixes, centrifugal, get supernatant, now with the current), with oily yarn, dressing, adhesive tape, fix, dismantle after 48h, see that wound has purulent secretion, excrement stink person arranged for the modeling success.
Rat model is divided into to model control group, conditioning liquid group, every group of 32 rats.Two groups of rats adopt normal saline to clean a wound, and adopt iodophor disinfection, wrapping dressing.Wherein, model control group is pressed penicillin sodium 140,000 units/kg intraperitoneal injection.The conditioning liquid group, except pressing penicillin sodium 140,000 units/kg intraperitoneal injection, while the conditioning liquid of embodiment 1 preparation being heated to 35-40 ℃, directly soaks wound into the liquid 30 minutes simultaneously, and morning, noon and afternoon every day respectively once.
The 3rd, 7,10,14 d after modeling, divide 4 batches (every batch every group 8 rats) to put to death rat, cut the 0.5cm*0.5cm granulation tissue at edge of wound, put in carnoy fluid fixedly 45min, paraffin embedding, section, row conventional H E dyeing, adopt light microscopic and MPIAS-500 color pathological picture and text analytical system to be observed.
The computing formula of wound surface CI: wound surface CI=(wound surface area/original wound surface area after the 1-treatment) * 100%.Result is referring to table 1.
Table 1 liang is formed face CI relatively (%)
Compare * with model control group
p<0.05, * *
p<0.01.
The fibroblast number: each specimen is observed 5 visuals field, fibroblast number in the counting granulation tissue, and average (fibroblast number/each visual field).Result is referring to table 2.
Table 2 liang is formed the comparison (individual/HPF) of fibroblast number in the face granulation tissue
Compare * with model control group
p<0.05, * *
p<0.01.
Granulation tissue is by a large amount of blood capillaries and tiny blood vessels and abundant fibroblast.Fibroblast is the topmost cell of repair in trauma.In cell proliferation and reparation phase, one of step of most critical is the formation of granulation tissue, and the essence of granulation tissue is a large amount of fibroblast and blood capillaries.After wound forms, fibroblast breeds, moves, and synthesizes, secretes collagen and extracellular matrix composition, participates in the process of granulation tissue formation, wound contraction and tissue reconstruction, and its number change can have an immense impact on to wound healing.According to the result of the test of table 1 and table 2, can find out, As time goes on, the conditioning liquid group is compared with model control group, aspect rat wound surface CI or fibroblast number, have significant difference (
p<0.05), even utmost point significant difference (
p<0.01), this illustrates that wound surface conditioning liquid of the present invention can improve the content of wound surface Granulation tissue fibroblasts, thus quick wound healing effectively.
Claims (2)
1. the conditioning liquid cleaned for postoperative wound, is characterized in that being prepared from by the Chinese crude drug of following weight portion: 12 parts of Os Draconis, 6 parts, Cinnabaris, 18 parts of Olibanums, 18 parts of Myrrhas, 18 parts of the Radixs Angelicae Dahuricae, 15 parts of Medulla Juncies, 2 parts of dried Alumens.
2. the conditioning liquid cleaned for postoperative wound as claimed in claim 1, it is characterized in that: described conditioning liquid is lotion.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210242884.2A CN102716281B (en) | 2012-07-15 | 2012-07-15 | Care solution for cleaning wounds after operation |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210242884.2A CN102716281B (en) | 2012-07-15 | 2012-07-15 | Care solution for cleaning wounds after operation |
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| Publication Number | Publication Date |
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| CN102716281A CN102716281A (en) | 2012-10-10 |
| CN102716281B true CN102716281B (en) | 2014-01-01 |
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