CN102716256B - Prepared rehmannia root Chinese medicinal preparation for treating headache and preparation method thereof - Google Patents
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Abstract
Description
技术领域 technical field
本发明属于中药领域,尤其涉及一种用于治疗头痛熟地黄中药制剂及制备方法。The invention belongs to the field of traditional Chinese medicines, and in particular relates to a traditional Chinese medicinal preparation of rehmannia glutinosa for treating headache and a preparation method thereof.
背景技术 Background technique
头痛是指由于外感与内伤,致使脉络拘急或失养,清窍不利所引起的以头部疼痛为主要临床特征的疾病,头痛既是一种常见病证,也是一个常见症状,可以发生于多种急慢性疾病过程中,有时亦是某些相关疾病加重或恶化的先兆,头痛出现将会严重影响人们的身体健康,且头痛病一般都具有病程长、治疗见效慢、费用高、愈后易复发等特点,目前国内外多采用西药治疗,星状神经节阻滞在疼痛治疗中较为常用,是治疗多种头面部疼痛和自主神经功能紊乱等疾病的有效手段,西医固有的对症治疗,忽视整体的治疗原则,使得它无法根治头痛,西医治疗头痛是针对引起头痛的外因,治标不治本,长久以来,西医治疗头痛着眼于“止痛”,但长期过量服用止痛药将引起药物依赖性和更严重的头痛,造成所谓的“止痛药反跳性头痛”或“药物诱导性头痛”。且西药治疗药费高,副作用大,还容易复发。中药药性平和,采用中医中药的手段来治疗头痛疾病,标本兼顾,是一极待开发的渠道,适用范围广,治疗方面有其独到的效果。Headache refers to a disease with head pain as the main clinical feature caused by exogenous pathogenic factors and internal injuries, resulting in tense veins or loss of nourishment, and poor clear orifices. Headache is not only a common syndrome, but also a common symptom. It can occur in multiple In the process of acute and chronic diseases, sometimes it is also a sign of aggravation or deterioration of certain related diseases. Headaches will seriously affect people's health, and headaches generally have a long course of disease, slow treatment, high cost, and easy recovery. Recurrence and other characteristics, at present, Western medicine is mostly used for treatment at home and abroad. Stellate ganglion block is more commonly used in pain treatment. The overall treatment principle makes it impossible to cure headaches. Western medicine treats headaches against the external causes of headaches, and treats the symptoms, not the root cause. For a long time, Western medicine treats headaches with a focus on "pain relief", but long-term excessive use of painkillers will cause drug dependence and more Severe headaches, causing so-called "rebound headaches from painkillers" or "drug-induced headaches." And the cost of Western medicine treatment is high, the side effects are large, and it is also easy to relapse. Traditional Chinese medicine is mild in nature, and it uses traditional Chinese medicine to treat headache diseases. It takes both specimens and specimens into account. It is a channel that is extremely waiting to be developed. It has a wide range of applications and has its own unique effects in treatment.
发明内容 Contents of the invention
本发明的目的就是为了克服已有技术的上述缺陷,提供一种具有配伍完善,无毒副作用,疗效可靠的治疗头痛熟地黄中药制剂及制备方法。The object of the present invention is to overcome the above-mentioned defects of the prior art, and provide a Chinese medicine preparation and a preparation method of Rehmannia glutinosa for treating headache with perfect compatibility, no toxic and side effects, and reliable curative effect.
为实现上述目的,本发明是通过以下技术方案实现的:To achieve the above object, the present invention is achieved through the following technical solutions:
治疗头痛熟地黄中药制剂,由以下重量份的中药原料制成:The rehmannia glutinosa traditional Chinese medicine preparation for treating headache is made from the following traditional Chinese medicine raw materials in parts by weight:
熟地黄200-400份、山茱萸200-300份、茯苓100-200份、决明子150-250份、女贞子50-150份、巴戟天50-150份。Rehmannia glutinosa 200-400 parts, Cornus officinalis 200-300 parts, Poria cocos 100-200 parts, Cassia seed 150-250 parts, Ligustrum lucidum 50-150 parts, Morinda officinalis 50-150 parts.
所述的治疗头痛熟地黄中药制剂,由以下重量份的中药原料制成:The described Rehmannia glutinosa Chinese medicine preparation for treating headache is made from the following Chinese medicine raw materials in parts by weight:
熟地黄300份、山茱萸250份、茯苓150份、决明子200份、女贞子100份、巴戟天100份。Rehmannia glutinosa 300 parts, Cornus officinalis 250 parts, Poria cocos 150 parts, Cassia seed 200 parts, Ligustrum lucidum 100 parts, Morinda officinalis 100 parts.
所述的治疗头痛熟地黄中药制剂的制备方法,其制备方法为:The preparation method of described rehmannia glutinosa traditional Chinese medicine preparation for the treatment of headache, its preparation method is:
按比例称取上述中药原料熟地黄300份、山茱萸250份、茯苓150份、决明子200份、女贞子100份、巴戟天100份,清洗晾干,粉碎成颗粒,加水浸泡1.5小时,然后加水煎煮两次,第一次加原料药8倍量的水,武火煎沸后,再文火煎煮1-2小时,取煎液、滤过,第二次加原料药6倍量的水,煎煮0.5-1.5小时,取两次煎液,滤过,热封袋中,每袋180ml,高温灭菌,包装即得。Weigh 300 parts of Rehmannia glutinosa, 250 parts of Cornus officinalis, 150 parts of Poria, 200 parts of Semen Cassiae, 100 parts of Ligustrum lucidum, and 100 parts of Morinda officinalis in proportion, wash and dry, crush into granules, add water to soak for 1.5 hours, and then Add water to decoct twice, add 8 times the amount of raw material medicine for the first time, boil with strong fire, then simmer for 1-2 hours, take the decoction, filter, add water 6 times the amount of raw material medicine for the second time , decoct for 0.5-1.5 hours, take two decoctions, filter, put in heat-sealed bags, 180ml per bag, sterilize at high temperature, and pack.
用法与用量:口服本发明中药制剂,每次180ml,每日2次,饭后半小时,1周为1个疗程。Usage and dosage: take the traditional Chinese medicine preparation of the present invention orally, 180ml each time, twice a day, half an hour after meals, and one week is a course of treatment.
本发明原料药的药理作用如下,熟地黄:甘,微温,归肝、肾经,养血滋阴、补精益髓;山茱萸:酸,微温,归肝、肾经,补益肝肾、收敛固涩;茯苓:甘、淡、平,归心、脾、肾经,利水渗湿、健脾、安神;决明子:甘、苦、微寒,归大肠经,清肝明目,润肠通便;女贞子:甘、苦、凉,归肝、肾经,补益肝肾、明目、清虚热;巴戟天:微温,辛、甘,入肾经,补肾阳、强筋骨、祛风湿;诸药共奏养阴补肾之功,本发明的中药制剂对内伤头痛肾虚型患者有显著治疗效果,可迅速缓解头痛且空,伴有眩晕,腰酸痛,疲乏,耳鸣失眠的症状,本制剂无毒副作用,治疗效果显著,从根本上解除了患者的痛苦。The pharmacological action of crude drug of the present invention is as follows, Rehmannia glutinosa: sweet, tepor, returns liver, kidney meridian, nourishes blood and nourishes yin, nourishes essence and marrow; Cornus officinalis: sour, lukewarm, returns liver, kidney meridian, nourishes liver and kidney, astringes and solidifies Poria cocos: sweet, light, flat, returning to the heart, spleen, kidney channel, diuresis and dampness, invigorating the spleen, calming the nerves; Semen Cassiae: sweet, bitter, slightly cold, returning to the large intestine channel, clearing the liver and improving eyesight, moisturizing the intestines and defecating; Son: sweet, bitter, cool, returns to liver, kidney meridian, nourishes liver and kidney, improves eyesight, clears deficiency and heat; Morinda officinalis: slightly warm, pungent, sweet, enters kidney meridian, nourishes kidney yang, strengthens muscles and bones, and dispels rheumatism; various medicines Playing the merits of nourishing yin and tonifying the kidney, the traditional Chinese medicine preparation of the present invention has a significant therapeutic effect on patients with internal injuries, headaches and kidney deficiency, and can quickly relieve symptoms of headache and emptyness, accompanied by dizziness, back pain, fatigue, tinnitus and insomnia, and the preparation has no toxic side effects , The treatment effect is remarkable, and the pain of the patient is fundamentally relieved.
具体实施方式 Detailed ways
实施例l:Embodiment 1:
中药原料:熟地黄300份、山茱萸250份、茯苓150份、决明子200份、女贞子100份、巴戟天100份。Chinese medicine raw materials: 300 parts of Rehmannia glutinosa, 250 parts of Cornus officinalis, 150 parts of Poria cocos, 200 parts of cassia seed, 100 parts of Ligustrum lucidum, and 100 parts of Morinda officinalis.
制备方法:按比例称取上述中药原料熟地黄300份、山茱萸250份、茯苓150份、决明子200份、女贞子100份、巴戟天100份,清洗晾干,粉碎成颗粒,加水浸泡1.5小时,然后加水煎煮两次,第一次加原料药8倍量的水,武火煎沸后,再文火煎煮1-2小时,取煎液、滤过,第二次加原料药6倍量的水,煎煮0.5-1.5小时,取两次煎液,滤过,热封袋中,每袋180ml,高温灭菌,包装即得。Preparation method: Weigh 300 parts of Rehmannia glutinosa, 250 parts of Cornus officinalis, 150 parts of Poria cocos, 200 parts of cassia seed, 100 parts of Ligustrum lucidum and 100 parts of Morinda officinalis in proportion, wash and dry, crush into granules, soak in water for 1.5 hour, then add water to decoct twice, add 8 times the amount of raw material medicine for the first time, boil with strong fire, then decoct with slow fire for 1-2 hours, take decoction, filter, add 6 times the amount of raw material medicine for the second time Take a certain amount of water, decoct for 0.5-1.5 hours, take two decoctions, filter, put in heat-sealed bags, 180ml per bag, sterilize at high temperature, and pack.
实施例2Example 2
中药原料:熟地黄400份、山茱萸300份、茯苓200份、决明子250份、女贞子150份、巴戟天150份。Raw materials of traditional Chinese medicine: 400 parts of Rehmannia glutinosa, 300 parts of Cornus officinalis, 200 parts of Poria cocos, 250 parts of cassia seed, 150 parts of Ligustrum lucidum, and 150 parts of Morinda officinalis.
制备方法:按比例称取上述中药原料熟地黄400份、山茱萸300份、茯苓200份、决明子250份、女贞子150份、巴戟天150份,清洗晾干,粉碎成颗粒,加水浸泡1.5小时,然后加水煎煮两次,第一次加原料药8倍量的水,武火煎沸后,再文火煎煮1-2小时,取煎液、滤过,第二次加原料药6倍量的水,煎煮0.5-1.5小时,取两次煎液,滤过,热封袋中,每袋180ml,高温灭菌,包装即得。Preparation method: Weigh 400 parts of Rehmannia glutinosa, 300 parts of Cornus officinalis, 200 parts of Poria cocos, 250 parts of cassia seed, 150 parts of Ligustrum lucidum, and 150 parts of Morinda officinalis in proportion to the above-mentioned traditional Chinese medicine raw materials, wash and dry, crush into granules, soak in water for 1.5 hour, then add water to decoct twice, add 8 times the amount of raw material medicine for the first time, boil with strong fire, then decoct with slow fire for 1-2 hours, take decoction, filter, add 6 times the amount of raw material medicine for the second time Take a certain amount of water, decoct for 0.5-1.5 hours, take two decoctions, filter, put in heat-sealed bags, 180ml per bag, sterilize at high temperature, and pack.
实施例3:Example 3:
中药原料:熟地黄200份、山茱萸200份、茯苓100份、决明子150份、女贞子50份、巴戟天50份。Chinese medicine raw materials: Rehmannia glutinosa 200 parts, Cornus officinalis 200 parts, Poria cocos 100 parts, Cassia seed 150 parts, Ligustrum lucidum 50 parts, Morinda officinalis 50 parts.
制备方法:按比例称取上述中药原料熟地黄200份、山茱萸200份、茯苓100份、决明子150份、女贞子50份、巴戟天50份,清洗晾干,粉碎成颗粒,加水浸泡1.5小时,然后加水煎煮两次,第一次加原料药8倍量的水,武火煎沸后,再文火煎煮1-2小时,取煎液、滤过,第二次加原料药6倍量的水,煎煮0.5-1.5小时,取两次煎液,滤过,热封袋中,每袋180ml,高温灭菌,包装即得。Preparation method: Weigh 200 parts of Rehmannia glutinosa, 200 parts of Cornus officinalis, 100 parts of Poria cocos, 150 parts of cassia seed, 50 parts of Ligustrum lucidum and 50 parts of Morinda officinalis in proportion, wash and dry, crush into granules, soak in water for 1.5 hour, then add water to decoct twice, add 8 times the amount of raw material medicine for the first time, boil with strong fire, then decoct with slow fire for 1-2 hours, take decoction, filter, add 6 times the amount of raw material medicine for the second time Take a certain amount of water, decoct for 0.5-1.5 hours, take two decoctions, filter, put in heat-sealed bags, 180ml per bag, sterilize at high temperature, and pack.
实施例4:Example 4:
临床试验Clinical Trials
1)一般资料:1) General information:
采用本发明中药制剂共治疗33例患者,其中男10例,女23例;年龄最大者78岁,年龄最小者35岁。Adopt Chinese medicine preparation of the present invention to treat 33 patients altogether, wherein 10 cases are male, 23 cases are female; The oldest person is 78 years old, and the youngest person is 35 years old.
2)诊断标准:主症头痛且空,伴有眩晕,腰酸痛,疲乏,耳鸣失眠,舌红少苔,脉细无力。2) Diagnostic criteria: main symptoms are headache and empty, accompanied by dizziness, back pain, fatigue, tinnitus, insomnia, red tongue with little coating, thready and weak pulse.
3)治疗方法:口服本发明实施例1中药汤剂,每次180ml,每日2次,饭后半小时,1周为1个疗程。3) Treatment method: Orally take the traditional Chinese medicine decoction of Example 1 of the present invention, 180ml each time, twice a day, half an hour after meals, and one week is a course of treatment.
4)疗效评价标准:4) Evaluation criteria for curative effect:
基本恢复:头痛消失,体征及症状完全改善,心情舒畅,精神焕发。Basic recovery: the headache disappeared, the signs and symptoms were completely improved, the mood was comfortable, and the spirit was refreshed.
显效:头痛基本消失,体征及症状显著改善,心情舒畅,精神很好。Significantly effective: the headache basically disappeared, the signs and symptoms were significantly improved, the mood was comfortable, and the spirit was very good.
有效:头痛改善,体征及症状有改变,偶感稍有不适,但能接受。Effective: The headache improved, the signs and symptoms changed, and I occasionally felt a little discomfort, but it was acceptable.
无效:体征无改变,症状如前。Ineffective: no change in signs, symptoms as before.
5)治疗结果:患者33例病例中,经两周治疗,其中基本恢复20例,显效5例,有效5例,无效3例,总有效率达90.9%。5) Treatment results: Among the 33 patients, after two weeks of treatment, 20 cases were basically recovered, 5 cases were markedly effective, 5 cases were effective, and 3 cases were ineffective, with a total effective rate of 90.9%.
实施例5:Example 5:
典型病例:王某,48岁,女,头痛,伴有眩晕,腰酸痛,疲乏,耳鸣失眠,舌红少苔,脉细无力,服用实施例1的中药制剂1周见效,2周基本恢复。Typical case: Wang, 48 years old, female, headache, accompanied by dizziness, sore waist, fatigue, tinnitus and insomnia, red tongue with less coating, thready and weak pulse, took the traditional Chinese medicine preparation of embodiment 1 to take effect in 1 week, and basically recovered in 2 weeks.
实施例6:Embodiment 6:
典型病例:施某,64岁,男,头痛且空,伴有眩晕,腰酸痛,疲乏,耳鸣失眠,舌红少苔,脉细无力,服用实施例1的中药制剂1周见效,2周基本恢复。Typical case: Shi Mou, 64 years old, male, headache and empty, accompanied by dizziness, waist pain, fatigue, tinnitus and insomnia, red tongue with less moss, thready and weak pulse, taking the traditional Chinese medicine preparation of Example 1 for 1 week to be effective, and 2 weeks for basic recover.
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CN1121811A (en) * | 1994-05-12 | 1996-05-08 | 广东医学院医药科技开发中心 | Drug prescription for treatment of neurosis and preparing method thereof |
CN1354014A (en) * | 2001-11-29 | 2002-06-19 | 廖干甫 | Gongbu ointment |
CN102366586A (en) * | 2011-09-28 | 2012-03-07 | 邓华伦 | Chinese herbal medicine for treating kidney deficiency, spleen dampness and headache |
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2012
- 2012-06-21 CN CN 201210208568 patent/CN102716256B/en active Active
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1121811A (en) * | 1994-05-12 | 1996-05-08 | 广东医学院医药科技开发中心 | Drug prescription for treatment of neurosis and preparing method thereof |
CN1354014A (en) * | 2001-11-29 | 2002-06-19 | 廖干甫 | Gongbu ointment |
CN102366586A (en) * | 2011-09-28 | 2012-03-07 | 邓华伦 | Chinese herbal medicine for treating kidney deficiency, spleen dampness and headache |
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