CN102697923B - Traditional Chinese medicine composition for preventing and treating pig immunosuppressive diseases - Google Patents
Traditional Chinese medicine composition for preventing and treating pig immunosuppressive diseases Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine composition for preventing and treating pig immunosuppressive diseases. The traditional Chinese medicine composition comprises the components in parts by weight as follows: 10 to 40 parts of evodia lepta, 10 to 35 parts of glabrous sarcandra glabrous herb, 25 to 45 parts of cyrtomium rhizome, 10 to 20 parts of bidens biternata, 10 to 35 parts of eucommia ulmoides oliv, and 2 to 10 parts of liquorice. The traditional Chinese medicine composition disclosed by the invention has scientific formula, and reasonable matching, and is efficient, safe, and residue-free. The traditional Chinese medicine composition can be used for activating the inhibited immune system of the pig, can improve the immunity of the pig, and guarantees that the pig has enough resistance to remove or kill infectious pathogens, therefore, the pig can regain health; and the illness and death of pig due to the immunosuppressive diseases and the secondary infection can be reduced; and the traditional Chinese medicine composition can be widely applied to prevent and treat the pig immunosuppressive diseases, as well as promoting the development of green pig industry..
Description
Technical field
The present invention relates to a kind of veterinary drug, be specifically related to a kind of for preventing and treating the Chinese medicine composition of pig immunosuppressive disease.
Background technology
In recent years, swine diseases is more and more, and increasingly sophisticated, controls difficulty increasing, has become the large outstanding problem facing in pig industry production.The various diseases of further investigation pig will be found, a lot " incurable disease " on veterinary clinic, basic reason is exactly swinery generation immunosuppressive disease, cause pig herd immunity and health level to decline, pig is increased the susceptibility of pathogen, cause breaking out the diseases such as mixed infection bacillary, viral and antibacterial and virus.
Cause that pig immunosuppressant sexual factor comprises mycotoxin, chemicals, malnutrition, distress and infectious disease, wherein infectious disease is the principal element that causes pig immunosuppressive disease, causes that pig transmissible immunosuppressive disease mainly comprises swine fever, pig breeding and breathing syndrome, circovirus disease, piglet multisystemic wasting syndrome, swine enzootic pneumonia, pseudorabies, porcine parvovirus etc.Inhibitive ability of immunity disease feature has: antibody response is lower than normal or expectation level, and makes vaccination can not reach expection immune effect, and the sickness rate of the concurrent or secondary infection of other cause of diseases increases, thereby causes the immunocompetence of pig to decline even dead.This be also why many raisers always ask " vaccine and immunity programm that I use are all no problem, but how or break out on a large scale this kind of disease, have the basic reason of various bacteria and viral infection ".
At present, immunostimulant for animals is mainly with chemicals, but because comprising some chemical synthetic drugs, medicine used often have administration time long, curative effect lasting time is short, drug residue, the shortcomings such as environmental pollution, and the immunne response of animal body, there is extremely complicated process, the participation of many factors, when so animal body produces immunosuppressant, normal is not that single chemo-immunity promoter can be proved effective, and often need body animal immune state to carry out across-the-board regulation, transfer all favorable factors of body, eliminating pathogenic factor for supporting vital QI, reach the object that strengthens immunologic function.And Chinese medicine source plant, animal, mineral, contain plurality of active ingredients, as polysaccharide, flavone, saponin, alkaloid, immunological enhancement has continuous action time length, drug residue free, animal body is stimulated to the advantages such as little, there are the effects such as the immune organ of quickening growth promoter, raising humoral immunization and cellular immune level, promotion cytokine secretion, anti-bacteria and anti-virus, so Chinese medicine becomes comparatively ideal immunostimulant.
Summary of the invention
The object of the present invention is to provide a kind of for preventing and treating the Chinese medicine composition of pig immunosuppressive disease, its efficient, safe noresidue, can be used for activating the repressed immune system of pig, strengthen pig immunologic function, guarantee that pig can have enough resistances to remove or kill the pathogen of infection, make the pig state of getting well, reduce and cause pig morbidity or dead because of immunosuppressive disease and secondary infection thereof.
For achieving the above object, the present invention adopts following technical scheme:
For preventing and treating a Chinese medicine composition for pig immunosuppressive disease, the parts by weight of its each component consist of: Foliumet Ramulus Evodiae 10-40 part, Herba Pileae Scriptae 10-35 part, Rhizoma Osmundae 25-45 part, Herba Bidentis Bipinnate (Herba Bidentis Pilosae, Herba Bidentis Pilosae) 10-20 part, Cortex Eucommiae 10-35 part, Radix Glycyrrhizae 2-10 part.
Should consist of for preventing and treating the parts by weight of its each component of Chinese medicine composition of pig immunosuppressive disease: Foliumet Ramulus Evodiae 15-30 part, Herba Pileae Scriptae 15-20 part, Rhizoma Osmundae 35-40 part, Herba Bidentis Bipinnate (Herba Bidentis Pilosae, Herba Bidentis Pilosae) 13-18 part, Cortex Eucommiae 15-25 part, Radix Glycyrrhizae 5-7 part.
Described medicine can be made powder, injection, oral liquid.
While making powder, take by weight proportion satisfactory medical material, pulverize, sieve, mix homogeneously, packing and get final product.
While making injection, oral liquid, add 6-12 doubly to measure purified water, extract 2-3 time, each 1-3 hour, merge extractive liquid,, cryogenic vacuum is concentrated, according to conventional method, removes impurity, adds conventional adjuvant, makes required Chinese medicine injection, oral liquid.
Know-why of the present invention: Foliumet Ramulus Evodiae: hardship, cold.Return liver, lung, stomach warp.Heat-clearing and toxic substances removing, dampness removing to stop itchin.Cure mainly calentura hyperpyrexia, laryngopharynx swelling and pain, hot carbuncle toxin, wet fiery osteodynia.Skin herpes simplex, skin pruritus are controlled in external.
Herba Pileae Scriptae: bitter, pungent, flat, GUIXIN, Liver Channel.Clearing away heat and cooling blood, the speckle removing of invigorating blood circulation, dispelling wind and removing obstruction in the collateral, cure mainly dysentery, influenza etc.
Rhizoma Osmundae: hardship, cold.Return liver, stomach warp.Anthelmintic, heat-clearing and toxic substances removing, hemostasis.Cure mainly abdominal pain due to worm stagnation, damp and hot sore, hemorrhage.
Herba Bidentis Bipinnate (Herba Bidentis Pilosae, Herba Bidentis Pilosae): hardship, flat.Return liver, lung, large intestine channel.Heat-clearing and toxic substances removing, dissipating blood stasis for subsidence of swelling.Cure mainly the diseases such as enteritis, bacillary dysentery, hepatitis, peritonitis, upper respiratory tract infection, tonsillitis, laryngitis, scald, traumatic injury, skin infection.
The Cortex Eucommiae: sweet, micro-pungent, temperature.Return liver, kidney channel.Invigorating the liver and kidney, bone and muscle strengthening, antiabortive.Cure mainly lumbago due to renal deficiency, rheumatic arthralgia, frequent fetal movement.
Radix Glycyrrhizae: sweet, flat.Return 12 warps.Invigorating the spleen and replenishing QI, expelling phlegm for arresting cough, and middle emergency, removing toxic substances, the mediation property of medicine.Cure mainly weakness of the spleen and stomach, cough with asthma, sore and toxic, laryngopharynx swelling and pain, poisoning.
The present invention compares and has following advantage with other products:
1, Chinese medicine composition compatibility of the present invention is reasonable, has elimination immunosuppressant, improves immunity, anti-inflammation, antiviral.Regularly or life-time service, can prevent pig generation immunosuppressive disease and eliminate immunosuppressant, strengthen pig immunologic function, anti-bacteria and anti-virus, avoids or reduces pig morbidity, accelerates the pig speed of growth, deliver for sale in advance, reduce production costs, increase economic benefit.
2, the made product safety of the present invention has no side effect, and is difficult for producing drug resistance, Pork and its products drug residue free, and production cost is low simultaneously, is beneficial to popularization.
The specific embodiment
Embodiment 1: a kind of enhancing immunologic function, antiviral Chinese medicine composition.According to weight below, take Chinese crude drug (kg): Foliumet Ramulus Evodiae 25, Herba Pileae Scriptae 15, Rhizoma Osmundae 35, Herba Bidentis Bipinnate (Herba Bidentis Pilosae, Herba Bidentis Pilosae) 18, the Cortex Eucommiae 25, Radix Glycyrrhizae 6, makes powder through pulverizing.
Preparation method: above-mentioned Chinese medicine is pulverized, crossed 300 mesh sieves, mix homogeneously, packing, every bag of 500g.
Embodiment 2: a kind of enhancing immunologic function, antiviral Chinese medicine composition.According to weight below, take Chinese crude drug (kg): Foliumet Ramulus Evodiae 30, Herba Pileae Scriptae 20, Rhizoma Osmundae 40, Herba Bidentis Bipinnate (Herba Bidentis Pilosae, Herba Bidentis Pilosae) 13, the Cortex Eucommiae 25, Radix Glycyrrhizae 7, is prepared into injection through water extract-alcohol precipitation.
Preparation method: add 100 ℃ of 12 times of amount purified water to extract twice the above-mentioned Chinese crude drug taking, extract 2 hours for the 1st time, extract 1.5 hours for the 2nd time, cryogenic vacuum is concentrated into 1: 1 (medicinal liquid: medical material), add 3 times of amount 95% ethanol, 4 ℃ standing 24 hours, high speed centrifugation, filter, filtrate recycling ethanol, in medicinal liquid, add 5 times of amount ethanol, 4 ℃ standing 24 hours, high speed centrifugation, filter, filtrate recycling ethanol, to in medicine liquid heating to 100 ℃ backward medicinal liquid, add 0.5% active carbon, 0.2% sodium sulfite, 0.05%EDTA2Na, and then heat 20 minutes, 4 ℃ standing 24 hours, high speed centrifugation, add appropriate injection water to the suitable medical material 2g of every 1ml, adjust pH is 6.0, filter, fill, sterilizing, obtain.
Embodiment 3: a kind of enhancing immunologic function, antiviral Chinese medicine composition.According to weight below, take Chinese crude drug (kg): by Foliumet Ramulus Evodiae 15, Herba Pileae Scriptae 20, Rhizoma Osmundae 35, Herba Bidentis Bipinnate (Herba Bidentis Pilosae, Herba Bidentis Pilosae) 15, the Cortex Eucommiae 15, Radix Glycyrrhizae 5, is prepared into oral liquid through water extract-alcohol precipitation.
Preparation method: add 100 ℃ of 10 times of purified water to extract 2 times to the Chinese crude drug taking, extract 2 hours for the 1st time, extract 1.5 hours for the 2nd time, cryogenic vacuum be concentrated into 1: 1 (medicinal liquid: medical material), add 3 times amount 95% ethanol, 4 ℃ are standing 24 hours, high speed centrifugation, filter, filtrate recycling ethanol, adds 0.1% sodium sorbate and appropriate purified water, every 1ml is equivalent to medical material 1g, adjust pH is 5.0, and fill, obtains.
Test determination result of use:
Test 1
Adopt embodiment tri-proportionings for preventing and treating the Chinese medicine composition of pig immunosuppressive disease, measure the Immune Function to immunosuppressed mice.
Kunming mouse, male and female half and half, body weight 20 ± 2.0g, injection cyclophosphamide (CY), manufactures immunosuppressant model.After manufacturing immunosuppressant model, oral Chinese medicine composition oral liquid of the present invention, observes the Immune Function of Chinese medicine composition to immunosuppressed mice.Be divided into 6 groups, 1 group is blank group, does not inject cyclophosphamide, only gives and which kind of identical normal saline of medicinal liquid; 5 groups are immunosuppressant group, and CY group gavages the normal saline identical with medicine liquid volume.Astragalus polysaccharides group, the high, medium and low dosage group of Chinese medicine composition gavage appropriate amount of drug, totally 60 of each groups, according to immunology immune indexes assay method, detect that spleen index, hemolysin formation, lymphocyte transformation, hemolysis plaque form, the immune indexes such as IgM and IgG in serum, the results are shown in Table 1, table 2
Table 1 causes immunocompromised mice hemolysin hemolysis plaque to cyclophosphamide (CY) and forms and the beyond challenge impact of lymphocyte
n=10)
Note: compare with CY group, * represents significant difference (P < 0.05), * * represents difference extremely significantly (P < 0.01)
The impact that mouse spleen index, hemolysin formation, lymphocyte transformation and hemolysis plaque are formed: blank group and CY group, difference is (P < 0.01) extremely significantly, illustrate and successfully set up immunosuppressant model, the high, medium and low dosage group of Chinese medicine composition and astragalus polysaccharides group remarkable (P < 0.05) or extremely significantly (P < 0.01) are higher than CY group,, there is statistical significance.
The impact of table 2 Chinese medicine composition on mice serum IgM and IgG
n=10)
Note: compare with CY group, * represents significant difference (P < 0.05), * * represents difference extremely significantly (P < 0.01)
Impact on mice serum IgM and IgG: blank group and CY group, difference is (P < 0.01) extremely significantly, illustrate and successfully set up immunosuppressant model, the high, medium and low dosage group of Chinese medicine composition and astragalus polysaccharides group remarkable (P < 0.05) or extremely significantly (P < 0.01), higher than CY group, have statistical significance.Result of the test shows, Chinese medicine composition can be eliminated immunity of organism inhibitory state, and in enhancing human body immunity function, especially Chinese medicine composition, dosage group effect is the most obvious.
Test 2
In May, 2011,800 growing and fattening pigs that Guangxi raiser raises, the about 60-65 kilogram of body weight.Due to change in weather, diseases induced, a small amount of pig fever, cough, asthma, the technician of plant heavy dose is used amikacin, dipyrone, moroxydine and the intramuscular injection of florfenicol medicine, treats 7 days, all lose curative effect, pig is morbidity and dead constantly, and morbidity pig reaches 300, dead 45, sickness rate 43.1%, mortality rate 5.6%.
Clinical symptoms: performance lassitude, be dried by thick unrest of hair, loss of appetite, feces and with mucus, the sick temperature of pig body of part is up to 41-42 ℃, be continued fever, under skin pore root, have, cough blue as speckle, the ear of rust sample, with the development of the state of an illness, breathe and be the devil, be ventral breathing, stream foam sample nose liquid, vomiting, one or more joint swelling and pains, muscular tremor, slowly, rear quarters rocks or crouches not rise wherein has 40 bulls to occur that appetite is absolutely useless in walking.
Pathological change: cut open 5 pigs that die of illness of inspection, pathological change is roughly the same.Cut open inspection visible: skin whitening, anemia and jaundice, visual mucosa is pale, anus and nostril are with kermesinus blood and solidify bad, subcutaneous fat degeneration, inside be full of bubble, abdominal cavity and pericardial effusion, hydrops solidifies and is gel-shaped, heart hat fat has diffuse hemorrhage point, liver blood stasis, enlargement, lung slightly expands, congested, edema, interstitial broadening, flow out foam-like liquid, kidney enlargement, color is light, bladder mucosa is congested, hemorrhage, especially lymphonodi mesosteniales inflammation swelling of lymph nodes of body as a whole, superficial inguinal lymph nodes xanthochromia, meninges is congested, hemorrhage, brain essence is hemorrhage.
According to clinical symptoms, pathological change tentative diagnosis, be reproductive and respiratory syndrome, Eperythrozoon, streptococcus mixed infection.Use Chinese medicine composition provided by the invention instead, for there being appetite pig, 5kg Chinese medicine composition composition powders provided by the invention is made an addition in 500kg feedstuff to mix homogeneously, mixed feeding, be used in conjunction 7 days, for appetite extreme difference pig, inject Chinese medicine composition composition injection provided by the invention, every 10ml, every day 2 times, to use latter the 2nd day, appetite extreme difference pig has a small amount of appetite; The 3rd day, appetite was recovered gradually, within the 4th day, changed powder spice mixed feeding into, use again 4 days, use after Chinese medicine composition provided by the invention and no longer include pig morbidity and dead, except 13 very serious sick pigs, it is normal that other sick temperature of pig body, appetite, spirit etc. are recovered, and effective percentage reaches 95.7%.
Claims (2)
1. for preventing and treating a Chinese medicine composition for pig immunosuppressive disease, it is characterized in that, the parts by weight of its each component consist of: Foliumet Ramulus Evodiae 15-30 part, Herba Pileae Scriptae 15-20 part, Rhizoma Osmundae 35-40 part, Herba Bidentis Bipinnate (Herba Bidentis Pilosae, Herba Bidentis Pilosae) 13-18 part, Cortex Eucommiae 15-25 part, Radix Glycyrrhizae 5-7 part.
2. according to claim 1 a kind of for preventing and treating the Chinese medicine composition of pig immunosuppressive disease, it is characterized in that: described medicine is made powder, injection, oral liquid.
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