CN102631421A - Traditional Chinese medicine for treating senile dementia - Google Patents
Traditional Chinese medicine for treating senile dementia Download PDFInfo
- Publication number
- CN102631421A CN102631421A CN2012101085328A CN201210108532A CN102631421A CN 102631421 A CN102631421 A CN 102631421A CN 2012101085328 A CN2012101085328 A CN 2012101085328A CN 201210108532 A CN201210108532 A CN 201210108532A CN 102631421 A CN102631421 A CN 102631421A
- Authority
- CN
- China
- Prior art keywords
- chinese medicine
- senile dementia
- traditional chinese
- new drug
- alzheimer disease
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 208000024827 Alzheimer disease Diseases 0.000 title claims abstract description 19
- 239000003814 drug Substances 0.000 title claims abstract description 17
- 206010039966 Senile dementia Diseases 0.000 title abstract description 6
- 238000002360 preparation method Methods 0.000 claims abstract description 9
- DTGKSKDOIYIVQL-WEDXCCLWSA-N (+)-borneol Chemical compound C1C[C@@]2(C)[C@@H](O)C[C@@H]1C2(C)C DTGKSKDOIYIVQL-WEDXCCLWSA-N 0.000 claims abstract description 6
- 239000007788 liquid Substances 0.000 claims abstract description 6
- 229930182490 saponin Natural products 0.000 claims abstract description 6
- 150000007949 saponins Chemical class 0.000 claims abstract description 6
- 235000017709 saponins Nutrition 0.000 claims abstract description 6
- TZJALUIVHRYQQB-XFDQAQKOSA-N Icariin Natural products O(C)c1ccc(C2=C(O[C@H]3[C@@H](O)[C@H](O)[C@@H](O)[C@H](C)O3)C(=O)c3c(O)cc(O[C@H]4[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O4)c(C/C=C(\C)/C)c3O2)cc1 TZJALUIVHRYQQB-XFDQAQKOSA-N 0.000 claims abstract description 5
- 235000003143 Panax notoginseng Nutrition 0.000 claims abstract description 5
- 241000180649 Panax notoginseng Species 0.000 claims abstract description 5
- TZJALUIVHRYQQB-XLRXWWTNSA-N icariin Chemical compound C1=CC(OC)=CC=C1C1=C(O[C@H]2[C@@H]([C@H](O)[C@@H](O)[C@H](C)O2)O)C(=O)C2=C(O)C=C(O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O3)O)C(CC=C(C)C)=C2O1 TZJALUIVHRYQQB-XLRXWWTNSA-N 0.000 claims abstract description 5
- TZJALUIVHRYQQB-UHFFFAOYSA-N icariine Natural products C1=CC(OC)=CC=C1C1=C(OC2C(C(O)C(O)C(C)O2)O)C(=O)C2=C(O)C=C(OC3C(C(O)C(O)C(CO)O3)O)C(CC=C(C)C)=C2O1 TZJALUIVHRYQQB-UHFFFAOYSA-N 0.000 claims abstract description 5
- 239000002775 capsule Substances 0.000 claims abstract description 4
- 239000004530 micro-emulsion Substances 0.000 claims abstract description 4
- 201000004810 Vascular dementia Diseases 0.000 claims abstract description 3
- 239000000839 emulsion Substances 0.000 claims abstract description 3
- 239000008187 granular material Substances 0.000 claims abstract description 3
- 239000007924 injection Substances 0.000 claims abstract description 3
- 238000002347 injection Methods 0.000 claims abstract description 3
- 239000006187 pill Substances 0.000 claims abstract description 3
- 239000007787 solid Substances 0.000 claims abstract description 3
- 239000003826 tablet Substances 0.000 claims abstract description 3
- 239000002547 new drug Substances 0.000 claims description 7
- 239000002552 dosage form Substances 0.000 claims description 5
- 229940079593 drug Drugs 0.000 claims description 4
- 239000000203 mixture Substances 0.000 claims description 4
- REPVLJRCJUVQFA-UHFFFAOYSA-N (-)-isopinocampheol Natural products C1C(O)C(C)C2C(C)(C)C1C2 REPVLJRCJUVQFA-UHFFFAOYSA-N 0.000 abstract 2
- 229940116229 borneol Drugs 0.000 abstract 2
- CKDOCTFBFTVPSN-UHFFFAOYSA-N borneol Natural products C1CC2(C)C(C)CC1C2(C)C CKDOCTFBFTVPSN-UHFFFAOYSA-N 0.000 abstract 2
- DTGKSKDOIYIVQL-UHFFFAOYSA-N dl-isoborneol Natural products C1CC2(C)C(O)CC1C2(C)C DTGKSKDOIYIVQL-UHFFFAOYSA-N 0.000 abstract 2
- 241001080798 Polygala tenuifolia Species 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
- 230000000694 effects Effects 0.000 description 6
- 230000002490 cerebral effect Effects 0.000 description 5
- 201000010099 disease Diseases 0.000 description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 4
- 238000011160 research Methods 0.000 description 3
- 239000002671 adjuvant Substances 0.000 description 2
- 238000011161 development Methods 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 230000008506 pathogenesis Effects 0.000 description 2
- 102000003914 Cholinesterases Human genes 0.000 description 1
- 108090000322 Cholinesterases Proteins 0.000 description 1
- 102000019197 Superoxide Dismutase Human genes 0.000 description 1
- 108010012715 Superoxide dismutase Proteins 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
- 229910052782 aluminium Inorganic materials 0.000 description 1
- 238000009412 basement excavation Methods 0.000 description 1
- 230000036770 blood supply Effects 0.000 description 1
- 210000004556 brain Anatomy 0.000 description 1
- 229940048961 cholinesterase Drugs 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 230000000378 dietary effect Effects 0.000 description 1
- 238000003912 environmental pollution Methods 0.000 description 1
- 230000002757 inflammatory effect Effects 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 230000002045 lasting effect Effects 0.000 description 1
- 206010025482 malaise Diseases 0.000 description 1
- 230000004089 microcirculation Effects 0.000 description 1
- 230000003285 pharmacodynamic effect Effects 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 238000012827 research and development Methods 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
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- Medicinal Preparation (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a traditional Chinese medicine for treating senile dementia. The novel medicament preparation is combined from four effective components such as polygala tenuifolia total saponins, borneol or natural borneol, notoginseng total saponins and icariin in a certain ratio and has special therapeutic effects for senile dementia and vascular dementia. The forms of the medicament can be solid preparations such as tablets, capsules, granules and pills, and can also be liquid preparations such as oral liquid, emulsion, microemulsion and injection.
Description
Technical field
The invention belongs to pharmaceutical sanitary field.
Background technology
Alzheimer disease is human commonly encountered diseases, frequently-occurring disease, difficult disease, owing to environmental pollution, dietary structure is unreasonable and its sickness rate of multiple reason such as wound, disease is fast rise trend, has a strong impact on people's health and patient's dignity.But the treatment alzheimer disease never has ideal medicament, and the anti-treatment of alzheimer disease almost is in stage at a loss what to do.Development treatment alzheimer disease has become the urgent and great problem of medicine research and development.Along with going deep into of scientific research; People more and more clearly recognize alzheimer disease be old body particularly in the cerebral tissue multiple factor imbalance as: blood supply in brain is not enough, big cerebral microcirculation disturbance, cerebral tissue cholinesterase activity are too high, cerebral tissue aluminum, lead, inflammatory factor level are too high, the cerebral tissue superoxide dismutase activity cross low etc. due to.The treatment alzheimer disease is not a target spot, the problem that ingredient can solve, and needs to take multicomponent, many target spots, multipath Comprehensive Treatment to etiology and pathogenesis.Chinese medicine has significant advantage and experience accumulation in this respect.But, the treatment alzheimer disease writes out a prescription in aspect defectives such as preparation technology, dosage form, drug loading, effective dose, compliances because need taking with traditional Chinese medicine for a long time; Chinese medicine is difficult to be not fully exerted in the curative effect aspect the treatment alzheimer disease, and the treatment advantage is not fully manifested.This research is exactly to start with from the experience prescription of the famous Traditional Chinese Medicine experts treatment of research excavation alzheimer disease, optimizes the Chinese medicine best prescription through pharmacology, pharmacodynamic study; Excellent through extracting purification, and then select " best compatibility " composition (component) and best proportion compatibility, and then " composition of medicine " of development treatment alzheimer disease.
To above problem, the novel anti senile dementia preparation that the present invention develops is fast to alzheimer disease Different types of etiopathogenises pathogenesis, determined curative effect, produce effects, lasting medicine, toxic and side effects are little, facilitate patients.
Summary of the invention
A kind of new drug of treating senile dementia is characterized in that it comprises the following aspects:
This new drug is made up of Radix Polygalae total saponins, Borneolum Syntheticum or natural Broneolum Syntheticum, Radix Notoginseng total arasaponins, icariin.
With the described drug ratios of claim 1 be: 0 ~ 500: 0 ~ 300: 0 ~ 500: 0 ~ 300.
The dosage form of this new drug is that this pharmaceutically dosage form is liquid preparations such as solid preparations such as tablet, capsule, granule, pill or oral liquid, mixture, Emulsion, microemulsion, injection.
It is dull-witted that this new drug is mainly used in treatment alzheimer disease, vascular dementia and mixed type.
Embodiment 1
Radix Polygalae total saponins, Borneolum Syntheticum or natural Broneolum Syntheticum, Radix Notoginseng total arasaponins, icariin: 300: 125: 360: 75, add suitable adjuvant, process capsule.
Embodiment 2
Radix Polygalae total saponins, Borneolum Syntheticum or natural Broneolum Syntheticum, Radix Notoginseng total arasaponins, icariin: 300: 125: 360: 75, add suitable adjuvant, process oral micro-emulsion.
Claims (4)
1. this new drug is made up of Radix Polygalae total saponins, Borneolum Syntheticum or natural Broneolum Syntheticum, Radix Notoginseng total arasaponins, icariin.
2. with the described drug ratios of claim 1 be: 0 ~ 500: 0 ~ 300: 0 ~ 500: 0 ~ 300.
3. the dosage form of this new drug is that this pharmaceutically dosage form is liquid preparations such as solid preparations such as tablet, capsule, granule, pill or oral liquid, mixture, Emulsion, microemulsion, injection.
4. it is dull-witted that this new drug is mainly used in treatment alzheimer disease, vascular dementia and mixed type.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2012101085328A CN102631421A (en) | 2012-04-14 | 2012-04-14 | Traditional Chinese medicine for treating senile dementia |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2012101085328A CN102631421A (en) | 2012-04-14 | 2012-04-14 | Traditional Chinese medicine for treating senile dementia |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN102631421A true CN102631421A (en) | 2012-08-15 |
Family
ID=46616100
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2012101085328A Pending CN102631421A (en) | 2012-04-14 | 2012-04-14 | Traditional Chinese medicine for treating senile dementia |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN102631421A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104721732A (en) * | 2015-02-04 | 2015-06-24 | 黑龙江中医药大学 | Chinese herbal medicine composition for treating senile dementia |
| CN105079090A (en) * | 2014-05-19 | 2015-11-25 | 四川省中医药科学院 | Pharmaceutical composition capable of preventing and treating senile dementia, medicine and preparation method thereof |
-
2012
- 2012-04-14 CN CN2012101085328A patent/CN102631421A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105079090A (en) * | 2014-05-19 | 2015-11-25 | 四川省中医药科学院 | Pharmaceutical composition capable of preventing and treating senile dementia, medicine and preparation method thereof |
| CN104721732A (en) * | 2015-02-04 | 2015-06-24 | 黑龙江中医药大学 | Chinese herbal medicine composition for treating senile dementia |
| CN104721732B (en) * | 2015-02-04 | 2019-05-03 | 黑龙江中医药大学 | Chinese herbal medicine composition for treating senile dementia |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20120815 |