CN102613297B - Milk for enhancing organism immunity and preparation process of milk - Google Patents
Milk for enhancing organism immunity and preparation process of milk Download PDFInfo
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- 235000013336 milk Nutrition 0.000 title claims abstract description 84
- 210000004080 milk Anatomy 0.000 title claims abstract description 84
- 239000008267 milk Substances 0.000 title claims abstract description 83
- 238000002360 preparation method Methods 0.000 title claims abstract description 30
- 230000036039 immunity Effects 0.000 title claims abstract description 23
- 230000002708 enhancing effect Effects 0.000 title description 3
- 239000002994 raw material Substances 0.000 claims abstract description 53
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- HEBKCHPVOIAQTA-NGQZWQHPSA-N d-xylitol Chemical compound OC[C@H](O)C(O)[C@H](O)CO HEBKCHPVOIAQTA-NGQZWQHPSA-N 0.000 claims abstract description 17
- 235000021255 galacto-oligosaccharides Nutrition 0.000 claims abstract description 17
- 150000003271 galactooligosaccharides Chemical class 0.000 claims abstract description 17
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- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Dairy Products (AREA)
Abstract
The invention discloses milk for regulating the organism immunity. Raw materials of the milk comprise the following ingredients in percentage by weight: 92 to 99 percent of raw material milk, 0.8 to 2.5 percent of fructo-oligose, 0.01 to 0.5 percent of xylo-oligosaccharide, 0.01 to 1 percent of galactooligosaccharide, 0.05 to 3 percent of inulin and organic selenium, wherein the selenium element in the organic selenium accounts for 1.4*10<-5> to 2.8*10<-5> percent of the total weight of the raw materials. The invention also discloses a preparation process of the milk for regulating the organism immunity. The long-short-chain compound prebiotics and organic selenium in a prior mixture ratio are added into the milk, and through the cooperated synergia effect between the substances, the growth and the propagation of the prebiotics in the intestinal tract can be promoted, so the effect of propagating the intestinal mucosal immune cells is realized, in addition, free radicals are favorably cleared, and the milk has the effect of obviously improving the immunity and can be drunk for a long time.
Description
Technical field
The present invention relates to field of liquid milk, relate in particular to a kind of milk and preparation technology thereof who strengthens immunity of organisms.
Background technology
Along with the fast development of Chinese national economy, fast pace, high efficiency Working and life styles, and the market competition of tackling various fiercenesses, increasing people, for a long time in sub-health state, causes body immunity to decline.Meanwhile, the rise day by day that the raising of living standards of the people and sustainable development view, quality of life are seen, the health care idea of people's science just progressively forms.The past outdated ideas of " ill just going seen the doctor " are desalinated just gradually, then pursue the fitness mode centered by self health care, administer voluntarily health.People, having higher requirement to varying the diet, aspect nutrition science, thirst for improving self the general level of the health and quality of life by adjustment of diet, extra-nutrition material, the object of reach health care, intelligence development, lengthening the life.Take a broad view of this health food quantity of several years, the product number of packages that strengthens immunity is maximum always, but the immune milk that the liquid milk of take is primary raw material is less, existing product mainly be take the liquid dairy product that colostrum is development of raw materials, because colostrums yield is very limited, heat endurance is bad, be difficult to collect and large-scale production, so this class has the very difficult large-scale production and selling of colostrum milk that strengthens immunity.
Summary of the invention
Technical problem to be solved by this invention is to overcome that existing immune milk output is little, poor heat stability, the defect that is difficult to large-scale production, and a kind of milk that strengthens immunity of organisms and preparation method thereof is provided.The present invention adds length chain compound " prebiotics " and the Organic Selenium of suitable proportioning in milk, by the synergistic function between these materials, can promote beneficial bacterium growth and breeding in enteron aisle, thereby play the effect of increment Intestinal Mucosal Immunization cell, also contribute to remove in addition free radical, make the effect of immunocompetence that increases significantly of this milk tool, and can eat for a long time.
The invention provides a kind of milk that regulates immunity of organisms, its raw material packet contains following component by weight percentage: raw material milk 92～99%, FOS 0.8～2.5%, xylo-oligosaccharide 0.01～0.5%, galactooligosaccharide 0.01～1%, inulin 0.05～3% and Organic Selenium; Selenium element in described Organic Selenium accounts for 1.4 * 10 of raw material gross weight
-5～2.8 * 10
-5%.
In the present invention one preferably in embodiment, described raw material comprises following component by weight percentage: raw material milk 96～98%, FOS 1.0～2.5%, xylo-oligosaccharide 0.1～0.5%, galactooligosaccharide 0.1～1%, inulin 0.5～3% and Organic Selenium; Selenium element in described Organic Selenium accounts for 2.0 * 10 of raw material gross weight
-5～2.8 * 10
-5%.
Wherein, described Organic Selenium is preferably Se-enriched yeast.
Wherein, described raw material milk can comprise the various raw material milks for the preparation of liquid milk in this area, as raw milk and/or recombined milk etc., is preferably raw milk.Described raw milk should meet the standard of GB-19301 < < food security national standard lactogenesis > >.Described recombined milk is to blend with milk powder, whey powder, rare cream and water etc. the milk forming.From the content of nutriment, consider, in raw material milk of the present invention protein content preferably >=2.9wt%, fat content can require to determine according to specific product, can select defatted milk, low fat milk or whole milk etc.
Wherein, described raw material also can comprise the conventional food additives that add in the liquid milk of this area, as stabilizing agent and/or flavor substance.
Described stabilizing agent can be selected various stabilizing agents conventional in milk production technology, generally various stabilizing agents or the composite compound stabilizer forming in GB2760, as one or more in single stearic acid glycerine lipoprotein fat acid esters, two glyceryl stearate fat acid esters, sucrose fatty ester, soybean lecithin, carragheen and microcrystalline cellulose etc.The consumption of described stabilizing agent is the conventional amount used of this area, is preferably 0.1～0.6%, and described percentage is the percentage by weight that accounts for raw material gross weight.
Described flavor substance can be selected the conventional various flavor substances that use in this area, as essence and/or mouthfeel modifying agent.Described essence can be selected the essence of the various routines in this area, as one or more in vanilla, milk flavour and fat flower bud etc.Described mouthfeel modifying agent can be selected the mouthfeel modifying agent of the various routines in this area, as one or more in enriching nutritious wheat flour, white granulated sugar, Sucralose and Aspartame etc.The consumption of described flavor substance is the conventional amount used of this area, is preferably below 0.8%, but does not comprise 0%, and described percentage is the percentage by weight that accounts for raw material gross weight.
The key technical indexes of the milk of adjusting immunity of organisms of the present invention is generally as follows:
The preparation technology of the milk of the adjusting immunity of organisms described in the present invention also provides, it comprises the steps: 1. described raw material milk to be mixed with described FOS, described xylo-oligosaccharide, described galactooligosaccharide, described inulin and described Organic Selenium, carry out protein and fatty standardization, stir; 2. double-stage homogenization; 3. sterilization; 4. cooling rear filling, obtain the milk of adjusting immunity of organisms of the present invention.
When raw material comprises stabilizing agent, 1. step carries out in the steps below: stabilizing agent is mixed with described raw material milk, mix with described FOS, described xylo-oligosaccharide, described galactooligosaccharide, described inulin and described Organic Selenium again, carry out protein and fatty standardization, stir.
When raw material comprises flavor substance, if described flavor substance is thermal sensitivity, after step double-stage homogenization 2., add; If described flavor substance is not thermal sensitivity, before step standardization 1., add.
Step 2. in, the conventional temperature that the temperature of described double-stage homogenization is this area, is preferably 65～75 ℃.The homogenization pressure of described double-stage homogenization is the homogenization pressure of this area routine, and wherein the pressure of first order homogeneous is preferably 22～25MPa, and the pressure of second level homogeneous is preferably 8～10MPa.
Step 3. in, described sterilization adopts the sterilization of milk method of this area routine to carry out, as pasteurize or ultra high temperature sterilization.
Step 4. in, the conventional chilling temperature that described cooling temperature is this area, is generally 2～6 ℃.
In the present invention, above-mentioned optimum condition can be combined on the basis that meets this area general knowledge, obtains each preferred embodiment of the present invention.
Raw material of the present invention and reagent is commercially available obtaining all.
Positive progressive effect of the present invention is:
1, dairy product of the present invention has been brought into play the synergistic function between each compound sugar well, with respect to adding single compound sugar of planting, there is the effect of very excellent adjusting immunity of organisms, and can promote the mineral absorptions such as Ca, Mg, be the functional milk of a taste sweet-smelling, delicate mouthfeel, met consumer for the demand that improves the milk of immunity of organisms.
2, preparation technology of the present invention can adopt the preparation method of this area routine to carry out, and for production equipment, there is no specific (special) requirements, can directly put into production.
The specific embodiment
Below in conjunction with embodiment, the present invention is described in further detail, but the present invention is not limited to this.
The experimental technique of unreceipted actual conditions in the following example, conventionally according to normal condition, or the condition of advising according to manufacturer.In the present invention, except special instruction, percentage used is all percentage by weight.The addition of the selenium in embodiment is in the amount of the selenium element in Organic Selenium.Production firm raw materials used in embodiment is as follows:
Raw material milk: He Sitan branch company of Shanghai Bright Dairy & Food Co., Ltd.,
FOS: Shanghai lattice are believed healthy Science and Technology Ltd.,
Xylo-oligosaccharide: Shandong Longli Biology Science and Technology Co., Ltd,
Galactooligosaccharide: Pan Asia dairy products (Shanghai) Co., Ltd.,
Inulin: Derby Europe, Guangzhou trade Co., Ltd,
Se-enriched yeast: Angel Yeast Co.,Ltd,
Stabilizing agent QSR-70 (form: single stearic acid glycerine lipoprotein fat acid esters, sucrose fatty ester, carragheen): upper sea blue Dao Jiali food additives Co., Ltd,
Stabilizing agent SR-16 (form: single stearic acid glycerine lipoprotein fat acid esters, sucrose fatty ester, soybean lecithin): upper sea blue Dao Jiali food additives Co., Ltd,
Stabilizing agent 9395-C (forming: microcrystalline cellulose, single stearic acid glycerine lipoprotein fat acid esters, sucrose fatty ester): Danisco (China) Co., Ltd,
Essence APG-07: Apple Flavor & Fragrance Group Co., Ltd.,
Enriching nutritious wheat flour: Shanghai Xin Rong industry development Co., Ltd.
Embodiment 1
Composition of raw materials:
Preparation technology:
1. stabilizing agent 9395-C is added in raw material milk, stir 10 minutes, add FOS, xylo-oligosaccharide, galactooligosaccharide, inulin and Se-enriched yeast, and carry out protein and fatty standardization, stir 10 minutes; 2. double-stage homogenization: homogenizing temperature: 70 ℃, the first order is at 23MPa, and carry out under 10MPa the second level; 3. sterilization: sterilization conditions is 120 ℃, the time is 15 seconds; 4. filling after being cooled to 2-6 ℃.
After adopting above-mentioned raw materials formula to make by described preparation technology, the assay of milk is as follows:
Embodiment 2
Composition of raw materials:
Preparation technology:
1. stabilizing agent QSR-70 is added in raw material milk, stir 10 minutes, add FOS, xylo-oligosaccharide, galactooligosaccharide, inulin and Se-enriched yeast, and carry out protein and fatty standardization, stir 10 minutes; 2. double-stage homogenization: homogenizing temperature: 65 ℃, the first order is at 22MPa, and carry out under 8MPa the second level; 3. add again essence BD-0025, stir 10 minutes; 4. sterilization: sterilization conditions is 85 ℃, the time is 15 seconds; 5. filling after being cooled to 2-6 ℃.
After adopting above-mentioned raw materials formula to make by described preparation technology, the assay of milk is as follows:
Embodiment 3
Composition of raw materials:
Preparation technology:
1. stabilizing agent SR-16 is added in raw material milk, stir 10 minutes, add FOS, xylo-oligosaccharide, galactooligosaccharide, inulin and Se-enriched yeast, and carry out protein and fatty standardization, stir 10 minutes; 2. double-stage homogenization: homogenizing temperature: 75 ℃, the first order is at 25MPa, and carry out under 8MPa the second level; 3. add again essence APG-07, stir 10 minutes; 4. sterilization: sterilization conditions is 120 ℃, the time is 15 seconds; 5. filling after being cooled to 2-6 ℃.
After adopting above-mentioned raw materials formula to make by described preparation technology, the assay of milk is as follows:
Embodiment 4
Composition of raw materials:
Preparation technology:
1. stabilizing agent QSR-70 is added in raw material milk, stir 10 minutes, add enriching nutritious wheat flour, FOS, xylo-oligosaccharide, galactooligosaccharide, inulin and Se-enriched yeast, and carry out protein and fatty standardization, stir 10 minutes; 2. double-stage homogenization: homogenizing temperature: 65 ℃, the first order is at 22MPa, and carry out under 10MPa the second level; 3. sterilization: sterilization conditions is 140 ℃, the time is 3 seconds; 4. filling after being cooled to 2-6 ℃.
After adopting above-mentioned raw materials formula to make by described preparation technology, the assay of milk is as follows:
Embodiment 5
Composition of raw materials:
Preparation technology:
1. stabilizing agent SR-16 is added in raw material milk, stir 10 minutes, add FOS, xylo-oligosaccharide, galactooligosaccharide, inulin and Se-enriched yeast, and carry out protein and fatty standardization, add essence APG-07, stir 10 minutes; 2. double-stage homogenization: homogenizing temperature: 70 ℃, the first order is at 25MPa, and carry out under 8MPa the second level; 3. add again essence APG-07, stir 10 minutes; 4. sterilization: 75 ℃ of sterilization conditions, the time is 15 seconds; 5. filling after being cooled to 2-6 ℃.
After adopting above-mentioned raw materials formula to make by described preparation technology, the assay of milk is as follows:
Embodiment 6
Composition of raw materials:
Preparation technology:
1. stabilizing agent 9395-C is added in raw material milk, stir 10 minutes, add enriching nutritious wheat flour, FOS, xylo-oligosaccharide, galactooligosaccharide, inulin and Se-enriched yeast, and carry out protein and fatty standardization, stir 10 minutes; 2. double-stage homogenization: homogenizing temperature: 65 ℃, the first order is at 24MPa, and carry out under 9MPa the second level; 3. sterilization: sterilization conditions is 135 ℃, the time is 3 seconds; 4. filling after being cooled to 2-6 ℃.
After adopting above-mentioned raw materials formula to make by described preparation technology, the assay of milk is as follows:
Embodiment 7
Composition of raw materials:
Preparation technology:
1. stabilizing agent 9395-C is added in raw material milk, stir 10 minutes, add FOS, xylo-oligosaccharide, galactooligosaccharide, inulin and Se-enriched yeast, and carry out protein and fatty standardization, stir 10 minutes; 2. double-stage homogenization: homogenizing temperature: 65 ℃, the first order is at 22MPa, and carry out under 9MPa the second level; 3. sterilization: sterilization conditions is 120 ℃, the time is 15 seconds; 4. filling after being cooled to 2-6 ℃.
After adopting above-mentioned raw materials formula to make by described preparation technology, the assay of milk is as follows:
Embodiment 8
Composition of raw materials:
Preparation technology:
1. stabilizing agent QSR-70 is added in raw material milk, stir 10 minutes, add white granulated sugar, FOS, xylo-oligosaccharide, galactooligosaccharide, inulin and Se-enriched yeast, and carry out protein and fatty standardization, stir 10 minutes; 2. double-stage homogenization: homogenizing temperature: 70 ℃, the first order is at 24MPa, and carry out under 9MPa the second level; 3. sterilization: 85 ℃ of sterilization conditions, the time is 15 seconds; 4. filling after being cooled to 2-6 ℃.
After adopting above-mentioned formula to make by described preparation technology, the assay of milk is as follows:
Embodiment 9
Composition of raw materials:
Preparation technology:
1. FOS, xylo-oligosaccharide, galactooligosaccharide, inulin and Se-enriched yeast are added in raw material milk, stir 10 minutes, and carry out protein and fatty standardization, then stir 10 minutes; 2. double-stage homogenization: homogenizing temperature: 67 ℃, the first order is at 24MPa, and carry out under 9MPa the second level; 3. sterilization: 85 ℃ of sterilization conditions, the time is 15 seconds; 4. filling after being cooled to 2-6 ℃.
After adopting above-mentioned formula to make by described preparation technology, the assay of milk is as follows:
Effect embodiment 1 the present invention strengthens the immunologic function effect assessment of the milk of immunity of organisms
What the pilot project of announcing for 2003 according to ministry of Health of China, test principle and result were judged tentatively provides as follows:
1. pilot project
1.1 body weight
The mensuration of 1.2 internal organs/weight ratio: thymus gland/body weight ratio (thymus index), spleen/body weight ratio (spleen index)
1.3 cellular immune function tests: mouse lymphocyte transformation experiment, delayed allergy experiment (DTH)
1.4 humoral immune function tests: antibody-producting cell detects, and serum hemolysin is measured
1.5 monocytes/macrophages functional tests: mouse carbon clearance test, Turnover of Mouse Peritoneal Macrophages is engulfed chicken red blood cell experiment
The test of 1.6NK cytoactive
2. the listed index of test principle is for must do project.
3. result is judged
Strengthen immunity function: Ren Liang aspect result is positive aspect four of cellular immune functions, humoral immune function, monocytes/macrophages function, NK cytoactive, can judge that this given the test agent has the effect of the immunity function of enhancing.
Wherein two experimental results in cellular immune function test event are all positive, or two dosage group results of arbitrary test are positive, can judge that cellular immune function test result is positive.Two experimental results in humoral immune function test event are all positive, or two dosage group results of arbitrary test are positive, can judge that humoral immune function test result is positive.Two experimental results in monocytes/macrophages functional test project are all positive, or two dosage group results of arbitrary test are positive, can judge that monocytes/macrophages functional test results is positive.Two experimental results in NK cytoactive functional test project are all positive, or two dosage group results of arbitrary test are positive, can judge that NK cytoactive test result is positive.
4. test method: 250 mouse are randomized into large group of five experiments by body weight, every group 50 (immune one group is carried out the test of NK cytoactive and lymphocyte transformation experiment, immune two groups are carried out DTH, spleen index and thymus index experiment, immune three groups are carried out antibody-producting cell detection and serum hemolysin mensuration, immune four groups are carried out carbon clearance test, and immune five groups are carried out the experiment of macrophage phagocytic chicken red blood cell.Each is tested and in large group, is equipped with blank group, milk control group and basic, normal, high dosage Zu Wuzu group, 10 of every groups.Basic, normal, high dosage group gives given the test agent (milk that embodiment 5 obtains) a.The time of giving is all 30 days.Blank group and milk control group give same dose, after 30 days, put to death mouse, carry out the check of indices.
(a indicates: human body recommended amounts is 500ml/60kg body weight.Because sample RD is very large, surpass animal Greatest load, therefore using the concentrated 100 times of test liquids as mouse test of the dairy product of embodiment 5 preparations, be equivalent to human body RD 5ml/60kg every day).
5. Data Processing in Experiment: add up with SPSS software.
6. experimental result
Immune one group (NK cytoactive, SPL transformation experiment) result (n=10) of table 1
From table 1: the NK cytoactive of 2.5ml/kg dosage group is significantly higher than blank group (p < 0.05) and milk control group (p < 0.05).The OD difference of 2.5ml/kg dosage group is significantly higher than blank group (p < 0.05) and milk control group (p < 0.05); Milk control group is a little more than blank group, but no difference of science of statistics.
Immune two groups (DTH, spleen index and thymus index experiment) results (n=10) of table 2
From table 2: the mouse thymus exponential sum spleen index of each group, all without significant difference.In DTH experiment, the left and right ear weight difference (swelling) of 2.5ml/kg dosage group is significantly higher than blank group (p < 0.01), is also significantly higher than milk control group (p < 0.05); Milk control group is a little more than blank group, but no difference of science of statistics.
Immune three groups (antibody-producting cell and hemolysin experiment) results (n=10) of table 3
From table 3: during antibody-producting cell detects, the plaque number of 2.5ml/kg dosage group is significantly higher than blank group (p < 0.01), is also significantly higher than milk control group (p < 0.05); Milk control group is a little more than blank group, but no difference of science of statistics.In serum hemolysin experiment, the antibody product of 2.5ml/kg dosage group is significantly higher than blank group (p < 0.01), is also significantly higher than milk control group (p < 0.05); Milk control group is a little more than blank group, but no difference of science of statistics.
Immune four groups (carbon is cleaned up experiment) results of table 4 (n=10)
From table 4: in carbon clearance test, the phagocytic index of 2.5ml/kg dosage group is significantly higher than blank (p < 0.01), is also significantly higher than milk control group (p < 0.05); Milk control group is a little more than blank group, but no difference of science of statistics.
Immune five groups (engulfing experiment) results of table 5 (n=10)
From table 5: mouse peritoneal is huge to be bitten west and run and engulf in chicken red blood cell experiment, and the phagocytic percentage of 0.8ml/kg and phagocytic index are all significantly higher than blank group (all p < 0.05); The phagocytic rate of 2.5ml/kg dosage group and phagocytic index are all significantly higher than blank group (all p < 0.01), are also significantly higher than milk control group (p < 0.01); Milk control group and blank group no difference of science of statistics.
7. conclusion: result shows, milk of the present invention has the function (effect of the enhancing immunity of other embodiment is suitable with embodiment 5) that strengthens immunity.
The milk that effect embodiment 2 the present invention strengthen immunity of organisms promotes the effect assessment that calcium, magnesium absorb
1 pilot project
Measure human body and ingest after tested milk (embodiment 2), the absorptivity of calcium and magnesium.
2 test methods
Choose the age and be 20 of the old men of 69 ± 2 years old.Before giving given the test agent, the aseptic experimenter's ight soil of taking, the absorptivity of mensuration calcium and magnesium.Experimenter takes tested milk every day 2 times, each 250mL, continuous 14 days.At the 14th day, the aseptic experimenter's ight soil of taking, detected the absorptivity of calcium and magnesium again.
Ca or Mg absorptivity are calculated by following formula:
The content of 3.1 atomic absorption spectroscopy determination picked-up calcium and excretion calcium
Accurately take liquor sample 5.0～10.0g in 250mL beaker in tall form, add mixed acid digestion liquid 20～30mL, upper cover surface plate.Be placed in hot digestion in electric hot plate or electric sand bath.When acid solution is very few as do not digested well, then add several milliliters of mixed acid digestion liquid, continue hot digestion, until water white transparency.Add water, heating is to remove unnecessary nitric acid.When in beaker, liquid approaches 2mL～3mL, take off cooling.With the lanthana solution of 20g/L, wash and shift in 10mL scale test tube, add lanthana solution and be settled to scale.
Sample, after wet method digestion, imports in atomic absorption spectrophotometer, after flame atomization, absorbs the resonance line of 422.7nm, and its uptake is directly proportional to content, more quantitative with standard series.
The mensuration of 3.2 atomic absorption spectroscopy determination picked-up magnesium and excretion magnesium:
The digestion method of sample in the digestion method same 3.1 of sample.With 10mL deionization, wash and be transferred in 10mL scale test tube, add water and be settled to scale.
Sample, after wet method digestion, imports in atomic absorption spectrophotometer, after flame atomization, absorbs the resonance line of 285.2nm, and its uptake is directly proportional to content, more quantitative with standard series.
4 result of the tests ingest dairy product of the present invention on the impact of calcium, magnesium absorption rate respectively in Table 6 and 7.
Table 6 ingest before and after the absorptivity result (n=20) of calcium
Table 7 ingest before and after the absorptivity result (n=20) of magnesium
From table 6 and 7, the milk of the present invention of ingesting can significantly promote the absorption (calcium of other embodiment, magnesium absorbing state suitable with embodiment 2) of calcium, magnesium after two weeks.
Claims (1)
1. regulate a milk for immunity of organisms, its raw material packet contains following component: raw material milk 990g, FOS 8g, xylo-oligosaccharide 0.1g, galactooligosaccharide 0.1g, inulin 0.5g, Se-enriched yeast 0.07g, stabilizing agent SR-16 1g, and essence APG-07 0.23g; Wherein, fat≤3.1% in described raw material milk, protein >=2.9%, non-fat solid >=8.1%, described percentage is mass percent, the Se content in described Se-enriched yeast is 2000ppm; Described milk is obtained by the preparation method's preparation comprising the steps: 1. stabilizing agent SR-16 is added in raw material milk, stir 10 minutes, add FOS, xylo-oligosaccharide, galactooligosaccharide, inulin and Se-enriched yeast, and carry out protein and fatty standardization, add essence APG-07, stir 10 minutes; 2. double-stage homogenization: homogenizing temperature: 70 ℃, the first order is at 25MPa, and carry out under 8MPa the second level; 3. add again essence APG-07, stir 10 minutes; 4. sterilization: 75 ℃ of sterilization conditions, the time is 15 seconds; 5. filling after being cooled to 2-6 ℃.
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| CN102771563A (en) * | 2012-08-15 | 2012-11-14 | 苏州硒谷科技有限公司 | Selenium-enriched milk product and production method thereof |
| CN104146248B (en) * | 2014-07-30 | 2016-06-01 | 广州施健生物科技有限公司 | A kind of immunity nourishment composition and application thereof |
| CN105341157A (en) * | 2015-09-30 | 2016-02-24 | 内蒙古蒙牛乳业（集团）股份有限公司 | Liquid dairy product and preparation method thereof |
| CN106615176A (en) * | 2016-12-16 | 2017-05-10 | 渤海大学 | Preparation methods of soybean-milk drink and soybean-milk solid drink which have functions of improving intestinal flora and improving body immunity |
| TWI658791B (en) | 2017-09-25 | 2019-05-11 | 愛之味股份有限公司 | Oligosaccharide-rich dairy product having the functions of regulating blood lipids, improving intestinal flora and improving immunity, and preparation method thereof |
| CN108713757A (en) * | 2018-06-04 | 2018-10-30 | 河南源隆生物科技有限公司 | A kind of composition and its preparation method and application improving gastrointestinal tract microenvironment |
| CN112273444A (en) * | 2020-09-18 | 2021-01-29 | 内蒙古欧世蒙牛乳制品有限责任公司 | Milk base material and dairy product containing same and capable of improving immunity |
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