CN102579625A - Preparation method of Chinese medicinal dropping pills for treating rheumatoid arthritis - Google Patents
Preparation method of Chinese medicinal dropping pills for treating rheumatoid arthritis Download PDFInfo
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- CN102579625A CN102579625A CN2012100577005A CN201210057700A CN102579625A CN 102579625 A CN102579625 A CN 102579625A CN 2012100577005 A CN2012100577005 A CN 2012100577005A CN 201210057700 A CN201210057700 A CN 201210057700A CN 102579625 A CN102579625 A CN 102579625A
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- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 54
- 239000003814 drug Substances 0.000 description 43
- 239000000843 powder Substances 0.000 description 26
- 229940079593 drug Drugs 0.000 description 24
- 238000002156 mixing Methods 0.000 description 22
- 238000000034 method Methods 0.000 description 15
- 238000010828 elution Methods 0.000 description 12
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 12
- 239000006187 pill Substances 0.000 description 11
- 230000006837 decompression Effects 0.000 description 10
- 238000004064 recycling Methods 0.000 description 10
- 239000011347 resin Substances 0.000 description 9
- 229920005989 resin Polymers 0.000 description 9
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- 241001057584 Myrrha Species 0.000 description 6
- 206010039073 rheumatoid arthritis Diseases 0.000 description 6
- 239000004863 Frankincense Substances 0.000 description 5
- 230000004927 fusion Effects 0.000 description 5
- 238000010438 heat treatment Methods 0.000 description 5
- 238000005325 percolation Methods 0.000 description 5
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- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 4
- 235000019425 dextrin Nutrition 0.000 description 4
- 239000000203 mixture Substances 0.000 description 4
- 238000002360 preparation method Methods 0.000 description 4
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- 244000082204 Phyllostachys viridis Species 0.000 description 2
- 235000015334 Phyllostachys viridis Nutrition 0.000 description 2
- 229920001030 Polyethylene Glycol 4000 Polymers 0.000 description 2
- 239000002671 adjuvant Substances 0.000 description 2
- 239000011425 bamboo Substances 0.000 description 2
- MTHSVFCYNBDYFN-UHFFFAOYSA-N diethylene glycol Chemical compound OCCOCCO MTHSVFCYNBDYFN-UHFFFAOYSA-N 0.000 description 2
- 229940008099 dimethicone Drugs 0.000 description 2
- 235000013870 dimethyl polysiloxane Nutrition 0.000 description 2
- 239000004205 dimethyl polysiloxane Substances 0.000 description 2
- 239000002552 dosage form Substances 0.000 description 2
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- AXTGDCSMTYGJND-UHFFFAOYSA-N 1-dodecylazepan-2-one Chemical compound CCCCCCCCCCCCN1CCCCCC1=O AXTGDCSMTYGJND-UHFFFAOYSA-N 0.000 description 1
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- 208000023275 Autoimmune disease Diseases 0.000 description 1
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- 229960003639 laurocapram Drugs 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
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- Medicines Containing Plant Substances (AREA)
Abstract
The invention relates to a preparation method of Chinese medicinal dropping pills which have functions of dispelling pathogenic wind and removing dampness, expelling coldness and activating blood, and relaxing tendons and relieving pains, and are used for treating rheumarthritis and rheumatoid arthritis. The Chinese medicinal dropping pills are prepared from the following raw material drugs: processed monkshood, processed kusnezoff monkshood root, notopterygium root, radix angelicae pubescentis, prepared aconite, frankincense, myrrh, Chinese angelica, medicinal cyathula root, pawpaw, ephedra, cassia twig, centipede, hemlock parsley and semen strychni pulveratum. The preparation method comprises the following steps: crushing the processed monkshood, the processing kusnezoff monkshood root and the prepared aconite into coarse powder; extracting by a percolation method, concentrating the percolation solution, eluting with macroporous resin, and concentrating the elution solution into extract; performing water extraction and alcohol precipitation on the Chinese angelica, the medicinal cyathula root, pawpaw, the ephedra, the cassia twig, the hemlock parsley, the notopterygium root and the radix angelicae pubescentis, concentrating supernatant into extract; and combining two extracts, drying with spray to obtain dry medicinal powder; and combining with the frankincense, the myrrh fine powder and the semen strychni pulveratum, and uniformly mixing with proper substrate, and dripping into cooling agent to prepare dropping pills. According to the preparation method, the process and technology of medical extraction are improved, and the prepared pill preparation has small dosage everyday per time, convenient taking, quick response and high bioavailability.
Description
Technical field
The present invention relates to a kind of dispeiling pathogenic wind and removing dampness that has, cold expelling is invigorated blood circulation, and the muscles and tendons relaxing to alleviate pain effect is used for the method for preparing of the Chinese medicine dripping pills of rheumatic arthritis and rheumatoid arthritis.
Background technology
Rheumatic arthritis be a kind of be the chronic general LADA autoimmune disease of characteristic with the articular synovitis.Synovitis is outbreak repeatedly lastingly, the destruction that can cause intraarticular cartilage and bone, and joint function disturbance, in addition maimed.Treating the common herbal species of this disease has conventional dosage forms such as rheumatism patch, unguentum, pill, tablet, and its extraction process is simpler, exists to use or take that inconvenience, bioavailability are not high, onset waits problem slowly.CN03125238.9 is a kind of medicine of treating rheumatoid arthritis, especially a kind of external used medicine of treating rheumatoid arthritis, the medicament that the present invention is processed by the following weight proportion raw material: end 10～15 parts; 7～9 parts on Bulbus Allii bar; 8～12 parts of Semen Allii Tuberosi; 4～7 parts in Eucalyptus globules Fruits; 3～5 parts of Caulis Sinomeniis; 2～4 parts of Radix Gentianae Macrophyllae.The invention still further relates to the method for preparing of this medicine, comprise the crude drug pretreatment; Fried; Concentrated medicament makes liquor strength reach 40～50%; Cooling, the aseptic packaging warehouse-in.CN03104821.8 is a kind of pharmaceutical composition of treating rheumatism, rheumatoid arthritis and limbs pain and preparation method thereof, and said composition is processed by 35 flavor crude drug such as Rhizoma Et Radix Notopterygii, Radix Angelicae Pubescentis, Radix Clematidis, Radix Gentianae Macrophyllae, Cortex Acanthopancis, and this method for preparing is to get plaster substrate; Dissolve with slow fire, under constantly stirring, add the category-A drug extract, after stirring; Add category-B medicated powder; Put into laurocapram again, stir, can spread out and paint plaster.Pharmaceutical composition of the present invention is to the treatment prolapse of lumbar intervertebral disc, and rheumatism, rheumatoid arthritis and soft tissue injury etc. have remarkable result.CN200610048463.0 is a kind of Chinese medicine of rheumatic arthritis and medicine that method for preparing is a kind of treatment of arthritis of treating; It is processed by following medicine, Rhizoma Gastrodiae 6-15g, Radix Achyranthis Bidentatae 6-15g, Stigma Croci 6-15g, windproof 6-15g, Radix Gentianae Macrophyllae 6-15g, Herba speranskiae tuberculatae 6-15g, Herba Lycopodii 6-15g, long 12 centimetres of thick bamboo tube, 3 centimetres, one opening of diameter, a sealing; Its preparation method does, the first step is placed on Rhizoma Gastrodiae, Radix Achyranthis Bidentatae, Stigma Croci, windproof, Radix Gentianae Macrophyllae, Herba speranskiae tuberculatae, Herba Lycopodii medicine pot the inside and pours suitable quantity of water into and decoct; Second step is when decocting to a certain degree (dripping into pearl), an end of thick bamboo tube opening put into medicinal liquid continue to decoct a period of time and get final product this medicine wind-damp dispelling, promoting blood circulation to remove obstruction in the collateral.
Summary of the invention
The technical problem that the present invention will solve is a kind of method for preparing of treating the Chinese medicine dripping pills of rheumatic arthritis of research, and with dispeiling pathogenic wind and removing dampness, cold expelling is invigorated blood circulation, and muscles and tendons relaxing to alleviate pain is used to treat rheumatic arthritis and rheumatoid arthritis.The present invention has improved the Technology of extract drugs; Few, the taking convenience of each dosage dropping pill formulation every day of processing, rapid-action, bioavailability is high; Can adapt to the more and more faster rhythm of life of contemporary people, more meet the development trend of modern Chinese medicine dosage form " three little, triple effect, five convenience ".
For addressing the above problem the present invention following technical proposals is provided.
A kind of Chinese medicine dripping pills preparation of treating rheumatic arthritis is processed by the following raw materials in part by weight medicine: 42 parts of Radix Aconiti Preparatas, 42 parts of Radix Aconiti Kusnezoffii Preparatas, 32 parts of Rhizoma Et Radix Notopterygiis, 32 parts of Radix Angelicae Pubescentiss, 6 parts of Radix Aconiti Lateralis Preparata, 15 parts of Olibanums, 15 parts of Myrrhas, 32 parts of Radix Angelicae Sinensis, 32 parts of Radix Cyathulaes, 25 parts of Fructus Chaenomeliss, 20 parts in Herba Ephedrae, 20 parts of Ramulus Cinnamomi, 50 parts of Scolopendras, 25 parts of Rhizoma Chuanxiongs, 50 parts of Semen Strychni Pulveratums.
Said preparation of drug combination method comprises the following steps:
A) take by weighing each crude drug Radix Aconiti Preparata, Radix Aconiti Kusnezoffii Preparata, Rhizoma Et Radix Notopterygii, Radix Angelicae Pubescentis, Radix Aconiti Lateralis Preparata, Olibanum, Myrrha, Radix Angelicae Sinensis, Radix Cyathulae, Fructus Chaenomelis, Herba Ephedrae, Ramulus Cinnamomi, Scolopendra, Rhizoma Chuanxiong, Semen Strychni Pulveratum, subsequent use;
B) crude drug Radix Aconiti Preparata, Radix Aconiti Kusnezoffii Preparata, Radix Aconiti Lateralis Preparata are ground into coarse powder, extract, collect percolate, concentrate the back and use the macroporous resin eluting, collect eluent, be condensed into extractum with percolation, subsequent use;
C) with crude drug Radix Angelicae Sinensis, Radix Cyathulae, Fructus Chaenomelis, Herba Ephedrae, Ramulus Cinnamomi, Rhizoma Chuanxiong, Rhizoma Et Radix Notopterygii, Radix Angelicae Pubescentis, decocte with water, after filtrating concentrated, it was an amount of to add ethanol, staticly settles, and gets supernatant concentration and becomes extractum, subsequent use;
D) with above-mentioned b) c) extractum of gained merges, and adds appropriate amount of auxiliary materials, mixing, spray drying, dry medicated powder, subsequent use;
E) with crude drug Olibanum, Myrrha, be ground into fine powder, sieve, merge with Semen Strychni Pulveratum and above-mentioned dry medicated powder, mixing, subsequent use;
F) it is an amount of to get substrate, and heating makes fusion, adds above-mentioned e) mixing fine powders of gained, mixing splashes in the coolant, processes drop pill, promptly gets.
Pharmaceutical composition according to the invention contains pharmaceutically acceptable oral formulations adjuvant.
In the preferred manufacturing procedure step b) is ground into coarse powder with crude drug Radix Aconiti Preparata, Radix Aconiti Kusnezoffii Preparata, Radix Aconiti Lateralis Preparata, uses 95% ethanol to be solvent, extract with percolation; Collect percolate, decompression recycling ethanol is concentrated into every milliliter of concentrated solution that contains the 0.5g crude drug, with D-101 macroporous resin eluting; Earlier use water elution, discard eluent, the ethanol elution of reuse 95%; Collect eluent, be condensed into extractum, subsequent use; Step c) is crude drug Radix Angelicae Sinensis, Radix Cyathulae, Fructus Chaenomelis, Herba Ephedrae, Ramulus Cinnamomi, Rhizoma Chuanxiong, Rhizoma Et Radix Notopterygii, Radix Angelicae Pubescentis, decocte with water 2 times, each 3 hours; Collecting decoction filters, filtrating concentrating put cold after; Adding ethanol is 80% to containing the alcohol amount in right amount, staticly settles, and gets the supernatant decompression recycling ethanol; Be concentrated into relative density 1.05～1.15, get extractum; Step d) is with above-mentioned b) c) merging of gained extractum, add an amount of dextrin, mixing, spray drying promptly gets dry medicated powder; It is an amount of that step f) is got substrate, and heating makes fusion, adds the mixing fine powders of step e) gained, and mixing splashes in the coolant, processes drop pill, promptly gets.
More than measure the relative density of extractum, all under it is 75 ℃ condition, carry out.
In the preferred method for preparing step b) is ground into coarse powder with crude drug Radix Aconiti Preparata, Radix Aconiti Kusnezoffii Preparata, Radix Aconiti Lateralis Preparata, uses 95% ethanol to be solvent, extract with percolation, collect percolate, decompression recycling ethanol is concentrated into every milliliter of concentrated solution that contains the 0.5g crude drug.After concentrated solution regulated pH=4.5 with hydrochloric acid, be added to the D-101 macroporous resin of pre-treatment, per 10 gram macroporous resin applied sample amounts are 8 gram medical materials, last kind of flow velocity 1ml/min; Left standstill 2 hours, and used water elution earlier, elution flow rate 1ml/min, it is closely colourless to be eluted to water liquid; Discard eluent, 95% ethanol elution of 10 times of resin volumes of reuse, be eluted to effluent colourless till, collect 95% ethanol elution; Decompression recycling ethanol is concentrated into relative density 1.10, gets extractum; Step c) is crude drug Radix Angelicae Sinensis, Radix Cyathulae, Fructus Chaenomelis, Herba Ephedrae, Ramulus Cinnamomi, Rhizoma Chuanxiong, Rhizoma Et Radix Notopterygii, Radix Angelicae Pubescentis, decocte with water 2 times, each 3 hours; Collecting decoction filters, and filtrating is concentrated into every milliliter of clear paste that contains the 2g crude drug; Put cold after, add ethanol in right amount to the alcohol amount of containing be 80%, staticly settle; Get the supernatant decompression recycling ethanol, be concentrated into relative density 1.10, get extractum; Step d) is with above-mentioned b) c) merging of gained extractum, the dextrin of adding clear paste amount 15%, mixing carries out spray drying, the spray drying condition: feed liquor speed 15%, 160～170 ℃ of inlet temperatures, outlet temperature are 75～85 ℃, promptly get dry medicated powder; Step f) is with the mixing fine powders of step e) gained: substrate=1: 1.5, and it is an amount of to get substrate PEG4000, and heating makes fusion, adds mixing fine powders, and mixing splashes in the refrigerative dimethicone, processes drop pill, promptly gets.
More than measure the relative density of extractum, all under it is 75 ℃ condition, carry out.
The specific embodiment
The raw materials used medicine Radix Aconiti Preparata of pharmaceutical composition of the present invention, Radix Aconiti Kusnezoffii Preparata, Rhizoma Et Radix Notopterygii, Radix Angelicae Pubescentis, Radix Aconiti Lateralis Preparata, Olibanum, Myrrha, Radix Angelicae Sinensis, Radix Cyathulae, Fructus Chaenomelis, Herba Ephedrae, Ramulus Cinnamomi, Scolopendra, Rhizoma Chuanxiong, Semen Strychni Pulveratum are commercially available, and meet standard under 2010 editions pharmacopeia continuous items.
The used oral formulations adjuvant of pharmaceutical composition of the present invention is commercially available, and meets standard under the pharmacopeia continuous item.
Embodiment 1, and a kind of method for preparing of treating the Chinese medicine dripping pills of rheumatic arthritis is that crude drug Radix Aconiti Preparata 42g, Radix Aconiti Kusnezoffii Preparata 42g, Radix Aconiti Lateralis Preparata 6g are ground into coarse powder, uses 95% ethanol to be solvent; Extract with percolation, collect percolate, decompression recycling ethanol is concentrated into every milliliter of concentrated solution that contains the 0.5g crude drug, with D-101 macroporous resin eluting; Earlier use water elution, discard eluent, the ethanol elution of reuse 95%; Collect eluent, be condensed into extractum, subsequent use; With crude drug Radix Angelicae Sinensis 32g, Radix Cyathulae 32g, Fructus Chaenomelis 25g, Herba Ephedrae 20g, Ramulus Cinnamomi 20g, Rhizoma Chuanxiong 25g, Rhizoma Et Radix Notopterygii 32g, Radix Angelicae Pubescentis 32g, decocte with water 2 times, each 3 hours; Collecting decoction filters, filtrating concentrating put cold after; Adding ethanol is 80% to containing the alcohol amount in right amount, staticly settles, and gets the supernatant decompression recycling ethanol; Be concentrated into relative density 1.05～1.15, get extractum; Two kinds of extractum of above-mentioned gained are merged, add an amount of dextrin, mixing, spray drying promptly gets dry medicated powder; With crude drug Olibanum 15g, Myrrha 15g, be ground into fine powder, sieve, merge with Semen Strychni Pulveratum 50g and above-mentioned dry medicated powder, mixing gets mixing fine powders, and is subsequent use; It is an amount of to get substrate, and heating makes fusion, adds above-mentioned mixing fine powders, and mixing splashes in the coolant, processes 1000 balls, promptly gets.
More than measure the relative density of extractum, all under it is 75 ℃ condition, carry out.
Embodiment 2; A kind of method for preparing of treating the Chinese medicine dripping pills of rheumatic arthritis; Be that crude drug Radix Aconiti Preparata 42g, Radix Aconiti Kusnezoffii Preparata 42g, Radix Aconiti Lateralis Preparata 6g are ground into coarse powder, use 95% ethanol to be solvent, extract with percolation; Collect percolate, decompression recycling ethanol is concentrated into every milliliter of concentrated solution that contains the 0.5g crude drug.After concentrated solution regulated pH=4.5 with hydrochloric acid, be added to the D-101 macroporous resin of pre-treatment, per 10 gram macroporous resin applied sample amounts are 8 gram medical materials, last kind of flow velocity 1ml/min; Left standstill 2 hours, and used water elution earlier, elution flow rate 1ml/min, it is closely colourless to be eluted to water liquid; Discard eluent, 95% ethanol elution of 10 times of resin volumes of reuse, be eluted to effluent colourless till, collect 95% ethanol elution; Decompression recycling ethanol is concentrated into relative density 1.10, gets extractum; With crude drug Radix Angelicae Sinensis 32g, Radix Cyathulae 32g, Fructus Chaenomelis 25g, Herba Ephedrae 20g, Ramulus Cinnamomi 20g, Rhizoma Chuanxiong 25g, Rhizoma Et Radix Notopterygii 32g, Radix Angelicae Pubescentis 32g, decocte with water 2 times, each 3 hours; Collecting decoction filters, and filtrating is concentrated into every milliliter of clear paste that contains the 2g crude drug; Put cold after, add ethanol in right amount to the alcohol amount of containing be 80%, staticly settle; Get the supernatant decompression recycling ethanol, be concentrated into relative density 1.10, get extractum; Two kinds of extractum of above-mentioned gained are merged, add the dextrin of clear paste amount 15%, mixing carries out spray drying, the spray drying condition: feed liquor speed 15%, and 160～170 ℃ of inlet temperatures, outlet temperature are 75～85 ℃, promptly get dry medicated powder; With crude drug Olibanum 15g, Myrrha 15g, be ground into fine powder, sieve, merge with Semen Strychni Pulveratum 50g and above-mentioned dry medicated powder, mixing gets mixing fine powders, and is subsequent use; The above-mentioned mixing fine powders of step: substrate=1: 1.5, it is an amount of to get substrate PEG4000, and heating makes fusion, adds above-mentioned mixing fine powders, and mixing splashes in the refrigerative dimethicone, processes 1000 balls, promptly gets.
More than measure the relative density of extractum, all under it is 75 ℃ condition, carry out.
Claims (3)
1. method for preparing of treating the Chinese medicine dripping pills of rheumatic arthritis is characterized in that the following step:
A) take by weighing each crude drug Radix Aconiti Preparata, Radix Aconiti Kusnezoffii Preparata, Rhizoma Et Radix Notopterygii, Radix Angelicae Pubescentis, Radix Aconiti Lateralis Preparata, Olibanum, Myrrha, Radix Angelicae Sinensis, Radix Cyathulae, Fructus Chaenomelis, Herba Ephedrae, Ramulus Cinnamomi, Scolopendra, Rhizoma Chuanxiong, Semen Strychni Pulveratum, subsequent use;
B) crude drug Radix Aconiti Preparata, Radix Aconiti Kusnezoffii Preparata, Radix Aconiti Lateralis Preparata are ground into coarse powder, extract, collect percolate, concentrate the back and use the macroporous resin eluting, collect eluent, be condensed into extractum with percolation, subsequent use;
C) with crude drug Radix Angelicae Sinensis, Radix Cyathulae, Fructus Chaenomelis, Herba Ephedrae, Ramulus Cinnamomi, Rhizoma Chuanxiong, Rhizoma Et Radix Notopterygii, Radix Angelicae Pubescentis, decocte with water, after filtrating concentrated, it was an amount of to add ethanol, staticly settles, and gets supernatant concentration and becomes extractum, subsequent use;
D) with above-mentioned b) c) extractum of gained merges, and adds appropriate amount of auxiliary materials, mixing, spray drying, dry medicated powder, subsequent use;
E) with crude drug Olibanum, Myrrha, be ground into fine powder, sieve, merge with Semen Strychni Pulveratum and above-mentioned dry medicated powder, mixing, subsequent use;
F) it is an amount of to get substrate, and heating makes fusion, adds above-mentioned e) mixing fine powders of gained, mixing splashes in the coolant, processes drop pill, promptly gets.
2. preparation of drug combination method according to claim 1, wherein
Step b) is ground into coarse powder with crude drug Radix Aconiti Preparata, Radix Aconiti Kusnezoffii Preparata, Radix Aconiti Lateralis Preparata, uses 95% ethanol to be solvent, extract with percolation; Collect percolate, decompression recycling ethanol is concentrated into every milliliter of concentrated solution that contains the 0.5g crude drug, with D-101 macroporous resin eluting; Earlier use water elution, discard eluent, the ethanol elution of reuse 95%; Collect eluent, be condensed into extractum, subsequent use; Step c) is crude drug Radix Angelicae Sinensis, Radix Cyathulae, Fructus Chaenomelis, Herba Ephedrae, Ramulus Cinnamomi, Rhizoma Chuanxiong, Rhizoma Et Radix Notopterygii, Radix Angelicae Pubescentis, decocte with water 2 times, each 3 hours; Collecting decoction filters, filtrating concentrating put cold after; Adding ethanol is 80% to containing the alcohol amount in right amount, staticly settles, and gets the supernatant decompression recycling ethanol; Be concentrated into relative density 1.05～1.15, get extractum; Step d) is with above-mentioned b) c) merging of gained extractum, add an amount of dextrin, mixing, spray drying promptly gets dry medicated powder; It is an amount of that step f) is got substrate, and heating makes fusion, adds the mixing fine powders of step e) gained, and mixing splashes in the coolant, processes drop pill, promptly gets.
More than measure the relative density of extractum, all under it is 75 ℃ condition, carry out.
3. preparation of drug combination method according to claim 2, wherein
Step b) is ground into coarse powder with crude drug Radix Aconiti Preparata, Radix Aconiti Kusnezoffii Preparata, Radix Aconiti Lateralis Preparata, uses 95% ethanol to be solvent, extract with percolation, collect percolate, decompression recycling ethanol is concentrated into every milliliter of concentrated solution that contains the 0.5g crude drug.After concentrated solution regulated pH=4.5 with hydrochloric acid, be added to the D-101 macroporous resin of pre-treatment, per 10 gram macroporous resin applied sample amounts are 8 gram medical materials, last kind of flow velocity 1ml/min; Left standstill 2 hours, and used water elution earlier, elution flow rate 1ml/min, it is closely colourless to be eluted to water liquid; Discard eluent, 95% ethanol elution of 10 times of resin volumes of reuse, be eluted to effluent colourless till, collect 95% ethanol elution; Decompression recycling ethanol is concentrated into relative density 1.10, gets extractum; Step c) is crude drug Radix Angelicae Sinensis, Radix Cyathulae, Fructus Chaenomelis, Herba Ephedrae, Ramulus Cinnamomi, Rhizoma Chuanxiong, Rhizoma Et Radix Notopterygii, Radix Angelicae Pubescentis, decocte with water 2 times, each 3 hours; Collecting decoction filters, and filtrating is concentrated into every milliliter of clear paste that contains the 2g crude drug; Put cold after, add ethanol in right amount to the alcohol amount of containing be 80%, staticly settle; Get the supernatant decompression recycling ethanol, be concentrated into relative density 1.10, get extractum; Step d) is with above-mentioned b) c) merging of gained extractum, the dextrin of adding clear paste amount 15%, mixing carries out spray drying, the spray drying condition: feed liquor speed 15%, 160～170 ℃ of inlet temperatures, outlet temperature are 75～85 ℃, promptly get dry medicated powder; Step f) is with the mixing fine powders of step e) gained: substrate=1: 1.5, and it is an amount of to get substrate PEG4000, and heating makes fusion, adds mixing fine powders, and mixing splashes in the refrigerative dimethicone, processes drop pill, promptly gets.
More than measure the relative density of extractum, all under it is 75 ℃ condition, carry out.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2012100577005A CN102579625B (en) | 2012-03-07 | 2012-03-07 | Preparation method of Chinese medicinal dropping pills for treating rheumatoid arthritis |
Applications Claiming Priority (1)
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104491818A (en) * | 2014-12-15 | 2015-04-08 | 刘国村 | Formula for treating rheumatoid rheumatic arthritis and preparation method thereof |
| CN105582096A (en) * | 2016-02-26 | 2016-05-18 | 南京正亮医药科技有限公司 | Preparation method and application of Feng Tong Ning tablet |
| CN105726802A (en) * | 2016-03-01 | 2016-07-06 | 南京正亮医药科技有限公司 | Preparation method and application of Bazheng tablets |
| CN106236985A (en) * | 2016-08-30 | 2016-12-21 | 山东沃华医药科技股份有限公司 | One treats wind chill blockage disease medicament and preparation method thereof |
| CN111375030A (en) * | 2020-04-20 | 2020-07-07 | 马应龙药业集团股份有限公司 | Traditional Chinese medicine gel for treating skin itch |
| CN111603508A (en) * | 2020-06-02 | 2020-09-01 | 杨芍 | Method for preparing traditional Chinese medicine external application powder for drawing, soaking and recovering primordial qi |
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| CN104491818A (en) * | 2014-12-15 | 2015-04-08 | 刘国村 | Formula for treating rheumatoid rheumatic arthritis and preparation method thereof |
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| CN111375030A (en) * | 2020-04-20 | 2020-07-07 | 马应龙药业集团股份有限公司 | Traditional Chinese medicine gel for treating skin itch |
| CN111375030B (en) * | 2020-04-20 | 2021-08-03 | 马应龙药业集团股份有限公司 | Traditional Chinese medicine gel for treating skin itch |
| CN111603508A (en) * | 2020-06-02 | 2020-09-01 | 杨芍 | Method for preparing traditional Chinese medicine external application powder for drawing, soaking and recovering primordial qi |
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