CN102579276B - Permeation-promoting combination for cosmetic - Google Patents
Permeation-promoting combination for cosmetic Download PDFInfo
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- CN102579276B CN102579276B CN 201210084983 CN201210084983A CN102579276B CN 102579276 B CN102579276 B CN 102579276B CN 201210084983 CN201210084983 CN 201210084983 CN 201210084983 A CN201210084983 A CN 201210084983A CN 102579276 B CN102579276 B CN 102579276B
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Abstract
本发明涉及一种化妆品用安全保湿促渗组合物，主要成分为氨基酸保湿剂（5%-15%重量）、透明质酸钠（1%-3%重量）、烟酰胺（5%-15%重量）、尿囊素（0.1%-0.5%重量）、去离子水（75%-77%重量）。本发明组合物主要根据角质层的含水量为环境相对湿度的函数，角质层经水合作用后，可膨胀成多孔状态，易于物质穿透的原理完成。氮酮促渗原理为改变皮肤色质层脂质与蛋白结构，增加角质流动性，使角质层的类脂质产生不规则排列。本发明组合物所含成分经实践证明为安全的，渗透机理也与氮酮不同，因此不会对皮肤造成潜在危害。本发明组合物中成分与凡士林等烷烃化合物配伍性良好，本发明组合物促渗作用优于氮酮。The invention relates to a safe moisturizing and penetration enhancing composition for cosmetics. The main components are amino acid moisturizer (5%-15% by weight), sodium hyaluronate (1%-3% by weight), nicotinamide (5%-15% weight), allantoin (0.1%-0.5% by weight), deionized water (75%-77% by weight). The composition of the invention is mainly completed based on the principle that the water content of the cuticle is a function of the relative humidity of the environment, and the cuticle can expand into a porous state after hydration and is easy for substances to penetrate. The principle of Azone to promote penetration is to change the lipid and protein structure of the skin chromatin layer, increase the fluidity of the cutin, and make the lipids in the cuticle irregularly arranged. The ingredients contained in the composition of the invention are proved to be safe by practice, and the penetration mechanism is also different from that of azone, so it will not cause potential harm to the skin. The ingredients in the composition of the invention have good compatibility with alkane compounds such as vaseline, and the penetration promoting effect of the composition of the invention is better than that of azone.
Description
Technical field
The present invention relates to the short compositions of oozing of the safe moisturizing of a kind of used for cosmetic.
Background technology
At present, the used for cosmetic penetrating agent is take laurocapram (hereinafter to be referred as azone) as main, laurocapram is called for short azone, chemical name 1-positive dodecyl aza cyclohepta ketone-22 ketone, a kind of osmotic absorption promoter that U.S. Nelson company succeeds in developing the eighties in 20th century, can change skin chromaticness layer lipid and protein structure, promote the drug percutaneous skin to absorb, can both strengthen its transdermal effect to hydrophilic and hydrophobic chemical compound, report that azone can increase the cutin flowability, make cuticular lipoids produce irregular alignment, and follicular orifice is widened, be conducive to medicine and absorb by horny layer.According to people such as Zhou Jinxu in the research that 2% azone aqueous solution changes the mouse skin Surface Ultrastructure, find that rimala appears in the part epidermis, there is a hole to reach 2～4 microns, the hydrocarbon compound compatibilities such as azone and vaseline, paraffin are poor in addition, composite use can reduction can lose or reduces and help osmosis, and azone still makes skin have the osmosis of helping in long-time after stopping using.
Summary of the invention
The present invention will solve the problem of obtaining and provide a kind of permeation-promoting combination for cosmetic, and this permeation-promoting combination for cosmetic uses safety, mechanism is obvious, compatibility is good.
Using for reference the medical domain achievement in research can find, the infiltration conduction of functional mass on skin undertaken by following approach:
1, medicine is transported and is absorbed by the dermal papilla layer, thereby enter when injected organism tissue by skin arterial channel, horny layer transhipment (comprising cell internal diffusion, intercellular substance diffusion) and epidermis deep layer, corium.
2, the material absorbing at skin point place.Compare with other places skin, the Skin at Acupoints impedance is low, electric capacity is large, current potential is high, is conducive to the Transdermal absorption of material.
3, the absorption of mucosa place material.Be the common medicine position of medicine external evenly such as the hypoglossis mucous membrane in oral cavity, nasal mucosa, mucous membrane of rectum etc., mucosa does not have horny layer, and that medicine penetrates is comparatively easy, speed is fast.
4, hydration.Cuticular water content is the function of envionmental humidity.Horny layer is expandable into porous state behind hydration, be easy to material and penetrate.Facts have proved that the percutaneous rate of functional mass can increase by 4 to 5 times, the colleague can also make Pi Wen increase to 37 ℃, the acceleration blood circulation from 32 ℃.
5, the effect of surfactant or transdermal enhancer.Such as laurocapram, dimethyl sulfoxide etc.
6, the facilitation of aromatic herbs.
Technical scheme provided by the invention is: permeation-promoting combination for cosmetic, main component are amino acid humectant (5%-15% weight), hyaluronate sodium (1%-3% weight), nicotiamide (5%-15% weight), allantoin (0.1%-0.5% weight), deionized water (75%-77% weight).
The present composition is the function of envionmental humidity according to cuticular water content mainly, and horny layer is expandable into porous state behind hydration, is easy to the principle that material penetrates and finishes.
1, short principle for a change skin chromaticness layer lipid and the protein structure of oozing of azone, it is mobile to increase cutin, makes cuticular lipoids produce irregular alignment.
2, present composition ingredient is proven as safety, and penetration mechanism is also different from azone, therefore can not cause potential hazard to skin
3, the alkane compound compatibilities such as composition and vaseline are good in the present composition,
4, the short effect of oozing of the present composition is better than azone.
The specific embodiment
Embodiment 1: permeation-promoting combination for cosmetic, formed by amino acid humectant 5%, hyaluronate sodium 2.5%, nicotiamide 15%, allantoin 0.5%, deionized water 77%, and described percentage ratio is weight ratio.
Get 100 ml beakers, add 77 gram deionizations, add hyaluronate sodium 2.5 grams, and use heating by electric cooker, be stirred to hyaluronate sodium with electric blender simultaneously and dissolve fully, be heated to 80 ℃ and add allantoin 0.5 gram, amino acid humectant 5 grams, after naturally being cooled to room temperature, add nicotiamide 15 grams, and supply volatilization water to 100 gram and namely finish.
Embodiment 2: amino acid humectant 15%, hyaluronate sodium 3%, nicotiamide 5%, allantoin 0.1%, deionized water 76.9%, described percentage ratio are weight ratio.
Get 100 ml beakers, add 76.9 gram deionizations, add hyaluronate sodium 3 grams, and use heating by electric cooker, be stirred to hyaluronate sodium with electric blender simultaneously and dissolve fully, be heated to 80 ℃ and add allantoin 0.1 gram, amino acid humectant 15 grams, after naturally being cooled to room temperature, add nicotiamide 5 grams, and supply volatilization water to 100 gram and namely finish.
Embodiment 3: amino acid humectant 11.7%, hyaluronate sodium 1%, nicotiamide 12%, allantoin 0.3%, deionized water 75%, described percentage ratio are weight ratio.
Get 100 ml beakers, add 75 gram deionizations, add hyaluronate sodium 1 gram, and use heating by electric cooker, be stirred to hyaluronate sodium with electric blender simultaneously and dissolve fully, be heated to 80 ℃ and add allantoin 0.3 gram, amino acid humectant 11.7 grams, after naturally being cooled to room temperature, add nicotiamide 12 grams, and supply volatilization water to 100 gram and namely finish.
The used amino acid humectant of the application is the commercially available prod, main component: natural trimethyl glycine, adopt color analyse isolation technics from the molasses of beet root, extracts make natural product, outward appearance: white crystalline powder content 〉=99% moisture :≤1.0% 5% aqueous solution pH:5.0-7.0.
The short effect of oozing of the present composition can be verified by cinnamic acid percutaneous (Corium Mus) permeability test, makes 5 samples before the experiment, distinguishes with A, B, C, D, E, and the concrete composition of each sample is as follows:
Sample A:99% deionized water, 0.1% cinnamic acid
Sample B:1% azone, 99% deionized water, 0.1% cinnamic acid
The compositions that the sample C:1% embodiment of the invention 1 obtains, 99% deionized water, 0.1% cinnamic acid
The compositions that the sample D:1% embodiment of the invention 2 obtains, 99% deionized water, 0.1% cinnamic acid
The compositions that the sample E:1% embodiment of the invention 3 obtains, 99% deionized water, 0.1% cinnamic acid
Sample F: 84.1% deionized water, 3% glyceryl monostearate, 3% vaseline, 2% white oil, 0.1% cinnamic acid, 0.3% carbomer, 0.3% triethanolamine, 1% azone, 5% glycerol, 0.2% germall, 0.1% essence.
Compositions, 5% glycerol, 0.2% germall, 0.1% essence that sample G:84.1% deionized water, 3% glyceryl monostearate, 3% vaseline, 2% white oil, 1% cinnamic acid, 0.3% carbomer, 0.3% triethanolamine, 1% embodiment of the invention 1 obtain.
Compositions, 5% glycerol, 0.2% germall, 0.1% essence that sample H:84.1% deionized water, 3% glyceryl monostearate, 3% vaseline, 2% white oil, 1% cinnamic acid, 0.3% carbomer, 0.3% triethanolamine, 1% embodiment of the invention 2 obtain.
Compositions, 5% glycerol, 0.2% germall, 0.1% essence that sample I:84.1% deionized water, 3% glyceryl monostearate, 3% vaseline, 2% white oil, 1% cinnamic acid, 0.3% carbomer, 0.3% triethanolamine, 1% embodiment of the invention 3 obtain.
Experimental result is as follows:
| Sample | Infiltration coefficient P * 10 -3（㎝/h） |
| A | 22.525±2.229 |
| B | 70.525±1.675 |
| C | 90.362±1.756 |
| D | 98.242±2.456 |
| E | 88.112±1.202 |
| F | 23.114±2.113 |
| G | 89.030±5.121 |
| H | 96.420±2.134 |
| I | 87.545±1.332 |
Shown in the result, azone is obvious to the cinnamic acid Penetration enhancing effect, and present composition Penetration enhancing effect is better than azone, and especially the composition effect that obtains of the embodiment of the invention 2 is more remarkable.But Penetration enhancing effect reduces obviously even does not have Penetration enhancing effect when azone and vaseline are composite, and the present composition and vaseline still show powerful Penetration enhancing effect when composite.
Claims (1)
1. permeation-promoting combination for cosmetic is comprised of amino acid humectant 5%-15%, hyaluronate sodium 1%-3%, nicotiamide 5%-15%, allantoin 0.1%-0.5%, deionized water 75%-77%; Above-mentioned percentage ratio is weight ratio.
2. permeation-promoting combination for cosmetic according to claim 1 is characterized in that: described amino acid humectant is 15%, hyaluronate sodium is 3%, nicotiamide is 5%, allantoin is 0.1%, deionized water is 76.9%, and described percentage ratio is weight ratio.
3. the preparation method of claim 1 or 2 described permeation-promoting combination for cosmetics, at first hyaluronate sodium is joined in the deionized water, stir, be heated to 80 ℃, after hyaluronate sodium dissolves fully, add allantoin and amino acid humectant, add nicotiamide after naturally being cooled to room temperature, namely obtain this permeation-promoting combination for cosmetic.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201210084983 CN102579276B (en) | 2012-03-28 | 2012-03-28 | Permeation-promoting combination for cosmetic |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201210084983 CN102579276B (en) | 2012-03-28 | 2012-03-28 | Permeation-promoting combination for cosmetic |
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| Publication Number | Publication Date |
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| CN102579276A CN102579276A (en) | 2012-07-18 |
| CN102579276B true CN102579276B (en) | 2013-04-10 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN 201210084983 Expired - Fee Related CN102579276B (en) | 2012-03-28 | 2012-03-28 | Permeation-promoting combination for cosmetic |
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Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108888581A (en) * | 2018-08-01 | 2018-11-27 | 江苏朗沁科技有限公司 | A kind of transdermal absorbing composition and its application |
| CN109953900A (en) * | 2019-05-05 | 2019-07-02 | 广东科盈科技有限公司 | A compound for enhancing penetration and absorption of skin care products and preparation method thereof |
| CN112245366B (en) * | 2020-11-24 | 2022-12-16 | 山东华熙海御生物医药有限公司 | Permeation-promoting composition containing hyaluronic acid and application of permeation-promoting composition in cosmetics |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1856294A (en) * | 2003-08-25 | 2006-11-01 | 弗米克斯有限公司 | Penetrating pharmaceutical foam |
| JP4685163B2 (en) * | 2005-07-08 | 2011-05-18 | ザ プロクター アンド ギャンブル カンパニー | Lipophilic personal care composition |
| WO2007102125A2 (en) * | 2006-03-06 | 2007-09-13 | The Procter & Gamble Company | Lipophilic personal care composition |
| US20090263340A1 (en) * | 2006-04-18 | 2009-10-22 | Dsm Ip Assets B.V. | Cosmetic compositions |
| GB2458228B (en) * | 2006-10-12 | 2011-02-23 | Rohto Pharma | External preparation for skin |
| JP2009073764A (en) * | 2007-09-20 | 2009-04-09 | Fujifilm Corp | Adhesive gel sheet for living body and sheet-like cosmetic using the same |
| FR2939799B1 (en) * | 2008-12-11 | 2011-03-11 | Sederma Sa | COSMETIC COMPOSITION COMPRISING ACETYL OLIGOGLUCURONANS. |
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