CN102579170A - Thermoplastic degradable fiber woven stent and preparation method thereof - Google Patents
Thermoplastic degradable fiber woven stent and preparation method thereof Download PDFInfo
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- 239000000835 fiber Substances 0.000 title claims abstract description 144
- 229920001169 thermoplastic Polymers 0.000 title claims abstract description 67
- 239000004416 thermosoftening plastic Substances 0.000 title claims abstract description 67
- 238000002360 preparation method Methods 0.000 title claims description 15
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 34
- 229920001661 Chitosan Polymers 0.000 claims abstract description 33
- 239000011248 coating agent Substances 0.000 claims abstract description 16
- 238000000576 coating method Methods 0.000 claims abstract description 16
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims description 39
- 229920001634 Copolyester Polymers 0.000 claims description 11
- JJTUDXZGHPGLLC-UHFFFAOYSA-N lactide Chemical compound CC1OC(=O)C(C)OC1=O JJTUDXZGHPGLLC-UHFFFAOYSA-N 0.000 claims description 11
- AEMRFAOFKBGASW-UHFFFAOYSA-N Glycolic acid Polymers OCC(O)=O AEMRFAOFKBGASW-UHFFFAOYSA-N 0.000 claims description 10
- 229920000954 Polyglycolide Polymers 0.000 claims description 10
- 229920002463 poly(p-dioxanone) polymer Polymers 0.000 claims description 10
- 239000000622 polydioxanone Substances 0.000 claims description 10
- RKDVKSZUMVYZHH-UHFFFAOYSA-N 1,4-dioxane-2,5-dione Chemical compound O=C1COC(=O)CO1 RKDVKSZUMVYZHH-UHFFFAOYSA-N 0.000 claims description 9
- 229920000747 poly(lactic acid) Polymers 0.000 claims description 9
- 238000000034 method Methods 0.000 claims description 8
- 229910001220 stainless steel Inorganic materials 0.000 claims description 8
- 239000010935 stainless steel Substances 0.000 claims description 8
- 238000002844 melting Methods 0.000 claims description 6
- 230000008018 melting Effects 0.000 claims description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 6
- PQLVXDKIJBQVDF-UHFFFAOYSA-N acetic acid;hydrate Chemical compound O.CC(O)=O PQLVXDKIJBQVDF-UHFFFAOYSA-N 0.000 claims description 4
- 238000009954 braiding Methods 0.000 claims description 4
- 238000001816 cooling Methods 0.000 claims description 4
- 238000001035 drying Methods 0.000 claims description 4
- 239000000463 material Substances 0.000 claims description 3
- 238000007654 immersion Methods 0.000 claims description 2
- 238000000465 moulding Methods 0.000 claims description 2
- 229920001610 polycaprolactone Polymers 0.000 claims description 2
- 239000004632 polycaprolactone Substances 0.000 claims description 2
- 150000002148 esters Chemical class 0.000 claims 2
- 238000009941 weaving Methods 0.000 abstract 1
- 239000002184 metal Substances 0.000 description 9
- 229920006237 degradable polymer Polymers 0.000 description 6
- 238000010438 heat treatment Methods 0.000 description 5
- 229920002972 Acrylic fiber Polymers 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 238000010828 elution Methods 0.000 description 2
- -1 glycolide Ester Chemical class 0.000 description 2
- 239000002861 polymer material Substances 0.000 description 2
- 208000031481 Pathologic Constriction Diseases 0.000 description 1
- 239000007857 degradation product Substances 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000007721 mold pressing method Methods 0.000 description 1
- 208000037804 stenosis Diseases 0.000 description 1
- 230000036262 stenosis Effects 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
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Abstract
本发明涉及热塑性可降解纤维编织具有甲壳胺涂层的支架，包括：(1)将可降解纤维编织成具有网状结构的管状物；(2)通过热处理或热压合的方法使管状物中的纤维在交叉点方式粘合，防止纤维的松散，且赋予支架以较高的径向支撑力；(3)对上述管状物采用甲壳胺-醋酸-水溶液涂复后，置入无水乙醇中，形成甲壳胺涂层；(4)在真空烘箱中除去乙醇，得到热塑性可降解纤维编织具有甲壳胺涂层的支架。支架具有较高的径向支撑力，在人体内可完全降解。The invention relates to a chitosan-coated stent braided by thermoplastic degradable fibers, comprising: (1) weaving the degradable fibers into a tubular object with a network structure; The fibers are bonded at the intersections to prevent the loosening of the fibers and give the stent a higher radial support force; (3) after the above-mentioned tube is coated with chitosan-acetic acid-water solution, it is placed in absolute ethanol , forming a chitosan coating; (4) removing ethanol in a vacuum oven to obtain a scaffold with a chitosan coating braided by thermoplastic degradable fibers. The stent has high radial support force and can be completely degraded in the human body.
Description
技术领域 technical field
本发明涉及一种热塑性可降解纤维编织支架及其制备方法，特别是涉及一种用于人体内部管道支撑、防止人体内部管道狭窄或堵塞的热塑性可降解纤维编织的支架及其的制备方法。The invention relates to a thermoplastic degradable fiber braided bracket and a preparation method thereof, in particular to a thermoplastic degradable fiber braided bracket used for supporting internal pipelines of a human body and preventing narrowing or blockage of human internal pipelines and a preparation method thereof.
背景技术 Background technique
由于各种原因，人体内部管道会发生狭窄或堵塞，目前使用金属支架来防治这类疾病。但是，金属支架难以取出，带来一些副作用。用可降解高分子材料制备支架是解决金属支架副作用的途径之一。但是，目前用可降解高分子材料制备的支架遇到径向支撑力不足的问题。提高可降解高分子材料支架的径向支撑力是使可降解高分子支架具有实用价值的一个关键。Due to various reasons, the internal pipes of the human body can become narrowed or blocked, and metal stents are currently used to prevent and treat such diseases. However, the metal stent is difficult to remove, which brings some side effects. Fabricating stents with degradable polymer materials is one of the ways to solve the side effects of metal stents. However, the current stents made of degradable polymer materials encounter the problem of insufficient radial support force. Improving the radial support force of degradable polymer scaffolds is a key to make degradable polymer scaffolds have practical value.
发明内容 Contents of the invention
本发明的目的是提供一种具有良好径向支撑力的热塑性可降解纤维编织的支架。The purpose of the present invention is to provide a thermoplastic degradable fiber braided stent with good radial support.
本发明的另一目的是提供一种具有良好径向支撑力的热塑性可降解纤维编织的支架的制备方法。Another object of the present invention is to provide a preparation method of a thermoplastic degradable fiber braided scaffold with good radial support.
本发明的又一目的是将具有良好径向支撑力的热塑性可降解纤维编织的支架用于人体内部管道支撑、防治人体内部管道狭窄或堵塞。Another object of the present invention is to use the stent braided by thermoplastic degradable fiber with good radial support force to support the internal pipeline of the human body, and prevent the stenosis or blockage of the internal pipeline of the human body.
本发明的再一目的是提供一种给上述支架施加具有多孔和粗糙表面的甲壳胺涂层的方法。Yet another object of the present invention is to provide a method for applying a chitosan coating having a porous and rough surface to the above-mentioned stent.
为达到以上目的，本发明采用的技术方案如下：For achieving above object, the technical scheme that the present invention adopts is as follows:
本发明的一种热塑性可降解纤维编织支架，是由热塑性可降解纤维交叉编织成的中空管状物，纤维和纤维在交叉点粘结在一起，不发生松散，支架具有较大的径向支撑力。A thermoplastic degradable fiber braided support of the present invention is a hollow tubular material cross-woven from thermoplastic degradable fibers, and the fibers are bonded together at the intersection point without loosening, and the support has a relatively large radial support force .
作为优选的技术方案：As a preferred technical solution:
如上所述的一种热塑性可降解纤维编织支架，所述的热塑性可降解纤维的单丝直径为0.1-0.6mm，所述的热塑性可降解纤维为聚丙交酯纤维、聚乙交酯纤维、丙交酯和乙交酯共聚酯纤维和聚对二氧杂环己酮纤维。A kind of thermoplastic degradable fiber braided support as mentioned above, the monofilament diameter of described thermoplastic degradable fiber is 0.1-0.6mm, and described thermoplastic degradable fiber is polylactide fiber, polyglycolide fiber, acrylic fiber Lactide and glycolide copolyester fibers and polydioxanone fibers.
如上所述的一种热塑性可降解纤维编织支架，所述的热塑性可降解纤维编织支架表面有甲壳胺薄膜层，所述的甲壳胺薄层表面呈亚光，具有多孔和较粗糙的特征。The above-mentioned thermoplastic degradable fiber braided bracket has a chitosan film layer on the surface of the thermoplastic degradable fiber braided bracket, and the chitosan thin layer has a matte surface and is porous and rough.
本发明还提供了一种热塑性可降解纤维编织支架的制备方法，包括以下步骤：The present invention also provides a preparation method of a thermoplastic degradable fiber braided support, comprising the following steps:
(1)将热塑性可降解纤维交叉编织成中空管状物；(1) cross-braiding thermoplastic degradable fibers into a hollow tube;
(2)将外径与最终所需要制备的支架内径相同的不锈钢管插入上述中空管状物中；(2) inserting a stainless steel tube having the same outer diameter as the inner diameter of the final stent to be prepared into the above-mentioned hollow tubular object;
(3)将中间插有不锈钢管的中空管状物置于热塑性可降解纤维的软化温度以上，熔融温度以下；(3) Place the hollow tubular object with the stainless steel tube inserted in the middle above the softening temperature of the thermoplastic degradable fiber and below the melting temperature;
(4)纤维和纤维在交叉点形成粘结，不发生松散，支架具有较大的径向支撑力；(4) Fibers and fibers form a bond at the intersection point without loosening, and the scaffold has a large radial support force;
(5)冷却，得到形状稳定的热塑性可降解纤维编织支架。(5) cooling to obtain a shape-stable thermoplastic degradable fiber braided support.
如上所述的制备方法，所述的热塑性可降解纤维的单丝纤度直径为0.1-0.6mm，所述的热塑性可降解纤维为聚丙交酯纤维、聚乙交酯纤维、丙交酯和乙交酯共聚酯纤维或聚对二氧杂环己酮纤维。According to the above-mentioned preparation method, the monofilament fineness diameter of the thermoplastic degradable fiber is 0.1-0.6mm, and the thermoplastic degradable fiber is polylactide fiber, polyglycolide fiber, lactide and glycolide Ester copolyester fiber or polydioxanone fiber.
如上所述的制备方法，形成粘结时采用模压的方法增加纤维交叉点的压力，使纤维和纤维在交叉点牢固粘合。According to the above-mentioned preparation method, the method of molding is used to increase the pressure at the intersection point of the fibers when forming the bond, so that the fibers are firmly bonded at the intersection point.
本发明又提供了一种制备热塑性可降解纤维编织支架的方法，包括以下步骤：The present invention also provides a method for preparing a thermoplastic degradable fiber braided support, comprising the following steps:
(1)将热塑性可降解纤维交叉编织成中空管状物；(1) cross-braiding thermoplastic degradable fibers into a hollow tube;
(2)将外径与最终所需要制备的支架内径相同的不锈钢管插入上述中空管状物中；(2) inserting a stainless steel tube having the same outer diameter as the inner diameter of the final stent to be prepared into the above-mentioned hollow tubular object;
(3)将中间插有不锈钢管的中空管状物置于热塑性可降解纤维的软化温度以上，熔融温度以下；(3) Place the hollow tubular object with the stainless steel tube inserted in the middle above the softening temperature of the thermoplastic degradable fiber and below the melting temperature;
(4)纤维和纤维在交叉点形成粘结；(4) Fibers and fibers form bonds at intersection points;
(5)冷却，得到形状稳定的热塑性可降解纤维编织支架；(5) cooling to obtain a shape-stable thermoplastic degradable fiber braided support;
(6)将甲壳胺醋酸-水溶液涂复于所述的热塑性可降解纤维编织支架表面，再浸入无水乙醇中，使甲壳胺析出，同时将醋酸洗脱，得到热塑性可降解纤维表面具有多孔和表面较粗糙的甲壳胺涂层的热塑性可降解纤维编织支架。(6) Coating the chitosan acetic acid-water solution on the surface of the thermoplastic degradable fiber braided support, and then immersing in absolute ethanol to precipitate the chitosan, and simultaneously elute the acetic acid to obtain a porous and porous surface of the thermoplastic degradable fiber. A thermoplastic degradable fiber braided scaffold with a rougher chitosan coating.
(7)在35-50℃真空烘箱中干燥15-30分钟，去除甲壳胺薄层中的乙醇。(7) Dry in a vacuum oven at 35-50° C. for 15-30 minutes to remove ethanol in the chitosan thin layer.
如上所述的制备方法，所述的甲壳胺-醋酸-水溶液中甲壳胺的质量浓度为2-4％，醋酸与水的质量比为：3-5∶100。According to the above preparation method, the mass concentration of chitosan in the chitosan-acetic acid-water solution is 2-4%, and the mass ratio of acetic acid to water is 3-5:100.
如上所述的制备方法，所述的无水乙醇的温度为20-30℃，支架浸入时间为10-20分钟。According to the above preparation method, the temperature of the absolute ethanol is 20-30° C., and the stent immersion time is 10-20 minutes.
如上所述的制备方法，所述的热塑性可降解纤维的单丝纤度直径为0.1-0.6mm，所述的热塑性可降解纤维为聚丙交酯纤维、聚乙交酯纤维、丙交酯和乙交酯共聚酯纤维、聚己内酯纤维或聚对二氧杂环己酮纤维。According to the above-mentioned preparation method, the monofilament fineness diameter of the thermoplastic degradable fiber is 0.1-0.6mm, and the thermoplastic degradable fiber is polylactide fiber, polyglycolide fiber, lactide and glycolide Ester copolyester fiber, polycaprolactone fiber or polydioxanone fiber.
具体实现过程：The specific implementation process:
采用直径0.1-0.6mm的热塑性可降解纤维，例如：聚丙交酯纤维、聚乙交酯纤维、丙交酯和乙交酯共聚酯纤维、聚对二氧杂环己酮纤维交叉编织成具有网状结构的管状物。采用纤维形态的可降解高聚物编织热塑性可降解纤维支架，其原因在于纤维形态的可降解高聚物具有较高的弯曲模量，可以赋予支架有较高的径向支撑力。将热塑性可降解纤维编织成的管状物套于金属棒上，在热塑性可降解纤维的软化点温度以上、熔点温度以下进行热处理，热处理的时间为5-15分钟。热塑性可降解纤维在软化点温度以上、熔点温度以下时发生软化和收缩，管状物的纤维与纤维的交叉点可发生粘合。也可以采用模具压合的方法，使纤维与纤维的交叉点更好的粘合。将温度降低到室温，热塑性可降解纤维重新硬化。经过热处理后，纤维与纤维之间粘合，热塑性可降解纤维编织的支架形状稳定，纤维与纤维间不容易发生松脱，支架具有较大的径向支撑力，且能在置入人体内部管道时缩小直径，顺利置入，然后撑开，达到支撑人体内部管道的作用。将甲壳胺-醋酸-水溶液(其中：甲壳胺的质量浓度为2-4％，醋酸与水的质量比为：3-5∶100)涂复与经过热处理的支架表面，再将支架置于20-30℃的无水乙醇中10-20分钟，醋酸被洗脱，甲壳胺快速析出，形成表面呈亚光、具有多孔和较粗糙特征的薄层，同时将醋酸洗脱。在35-50℃真空烘箱中干燥15-30分钟，去除甲壳胺薄层中的乙醇。Use thermoplastic degradable fibers with a diameter of 0.1-0.6mm, such as: polylactide fiber, polyglycolide fiber, lactide and glycolide copolyester fiber, polydioxanone fiber cross-woven into a Network-like tubes. The degradable polymer in fiber form is used to weave the thermoplastic degradable fiber scaffold, because the degradable polymer in fiber form has a higher flexural modulus, which can endow the scaffold with a higher radial support force. The tubular object woven by thermoplastic degradable fibers is placed on a metal rod, and heat treatment is carried out at a temperature above the softening point and below the melting point of the thermoplastic degradable fibers, and the heat treatment time is 5-15 minutes. The thermoplastic degradable fiber softens and shrinks when it is above the softening point temperature and below the melting point temperature, and the intersection point of the fiber and the fiber of the tube can be bonded. The mold pressing method can also be used to better bond the intersection points of fibers and fibers. Lower the temperature to room temperature and the thermoplastic degradable fibers harden again. After heat treatment, the fibers are bonded to each other, the shape of the thermoplastic degradable fiber-woven scaffold is stable, and the fibers are not easy to loosen, the scaffold has a large radial support force, and can be placed in the human body When the diameter is reduced, it is inserted smoothly, and then stretched to support the internal pipeline of the human body. Coating the chitosan-acetic acid-water solution (wherein: the mass concentration of chitosan is 2-4%, the mass ratio of acetic acid to water: 3-5:100) is coated with the surface of the heat-treated stent, and then the stent is placed in 20 In absolute ethanol at -30°C for 10-20 minutes, acetic acid is eluted, and chitosan is rapidly precipitated to form a thin layer with matte surface, porous and rough features, and acetic acid is eluted at the same time. Dry in a vacuum oven at 35-50°C for 15-30 minutes to remove ethanol in the chitosan thin layer.
有益效果Beneficial effect
1、本发明的支架具有良好的径向支撑能力，可以有效地支撑起人体内部管道、防止人体内部管道狭窄或堵塞。1. The stent of the present invention has good radial support ability, can effectively support the internal pipeline of the human body, and prevent the internal pipeline of the human body from being narrowed or blocked.
2、本发明的支架在完成其功效后，可以完全降解，不再停留在人体内。2. After the stent of the present invention completes its function, it can be completely degraded and no longer stays in the human body.
3、本发明的支架具有具有甲壳胺涂层，可以消除或缓解支架降解产物对机体的刺激。3. The stent of the present invention has a chitosan coating, which can eliminate or alleviate the stimulation of the body by degradation products of the stent.
4、本发明的支架具有具有甲壳胺涂层表面多孔粗糙，有利于附加涂层的粘附。4. The stent of the present invention has a porous and rough surface of the chitosan coating, which is beneficial to the adhesion of the additional coating.
具体实施方式 Detailed ways
下面结合具体实施方式，进一步阐述本发明。应理解，这些实施例仅用于说明本发明而不用于限制本发明的范围。此外应理解，在阅读了本发明讲授的内容之后，本领域技术人员可以对本发明作各种改动或修改，这些等价形式同样落于本申请所附权利要求书所限定的范围。The present invention will be further described below in combination with specific embodiments. It should be understood that these examples are only used to illustrate the present invention and are not intended to limit the scope of the present invention. In addition, it should be understood that after reading the teachings of the present invention, those skilled in the art can make various changes or modifications to the present invention, and these equivalent forms also fall within the scope defined by the appended claims of the present application.
本发明的一种热塑性可降解纤维编织支架，是由热塑性可降解纤维交叉编织成的中空管状物，纤维和纤维在交叉点粘结在一起，不发生松散，支架具有较大的径向支撑力。A thermoplastic degradable fiber braided support of the present invention is a hollow tubular material cross-woven from thermoplastic degradable fibers, and the fibers are bonded together at the intersection point without loosening, and the support has a relatively large radial support force .
如上所述的一种热塑性可降解纤维编织支架，所述的热塑性可降解纤维的单丝直径为0.1-0.6mm，所述的热塑性可降解纤维为聚丙交酯纤维、聚乙交酯纤维、丙交酯和乙交酯共聚酯纤维或聚对二氧杂环己酮纤维。A kind of thermoplastic degradable fiber braided support as mentioned above, the monofilament diameter of described thermoplastic degradable fiber is 0.1-0.6mm, and described thermoplastic degradable fiber is polylactide fiber, polyglycolide fiber, acrylic fiber Lactide and glycolide copolyester fibers or polydioxanone fibers.
如上所述的一种热塑性可降解纤维编织支架，所述的热塑性可降解纤维编织支架表面有甲壳胺薄膜层，所述的甲壳胺薄层表面呈亚光，具有多孔和较粗糙的特征。The above-mentioned thermoplastic degradable fiber braided bracket has a chitosan film layer on the surface of the thermoplastic degradable fiber braided bracket, and the chitosan thin layer has a matte surface and is porous and rough.
实施例1Example 1
将直径为0.2mm的丙交酯和乙交酯共聚酯纤维交叉编织成内径为6mm的具有网状结构的管状物，再将这一管状物套在外径为6mm的金属棒上，置于80℃烘箱中5分钟后，纤维在交叉点相互粘结，再予以冷却、取下，得到纤维不发生松散的管状物。Cross-braid lactide and glycolide copolyester fibers with a diameter of 0.2mm into a tubular object with a network structure with an inner diameter of 6mm, and then put this tubular object on a metal rod with an outer diameter of 6mm, and place it on the After being placed in an oven at 80°C for 5 minutes, the fibers are bonded to each other at the crossing points, and then cooled and removed to obtain a tube without loose fibers.
在经过热处理的上述管状物表面涂复甲壳胺-醋酸-水溶液，甲壳胺-醋酸-水溶液中甲壳胺的质量浓度为2％，醋酸与水的质量比为3∶100，涂复量为每厘米管状物0.023克，然后将涂复有甲壳胺-醋酸-水溶液管状物置于20℃无水乙醇中，摇动10分钟后取出；再置于新鲜的20℃无水乙醇中，摇动10分钟后取出，以彻底洗脱醋酸；再在35℃真空烘箱中干燥30分钟，除去乙醇，即得到具有甲壳胺涂层的丙交酯和乙交酯共聚酯纤维支架。这种支架每cm的径向支撑力为195厘牛。Coat the chitosan-acetic acid-water solution on the above-mentioned tubular body through heat treatment, the mass concentration of chitosan in the chitosan-acetic acid-water solution is 2%, the mass ratio of acetic acid and water is 3: 100, and coating amount is every centimeter of tubular body 0.023 g, then place the tube coated with chitosan-acetic acid-water solution in 20°C absolute ethanol, shake it for 10 minutes and take it out; then put it in fresh 20°C absolute alcohol, shake it for 10 minutes Elution of acetic acid; drying in a vacuum oven at 35°C for 30 minutes to remove ethanol to obtain a lactide and glycolide copolyester fiber scaffold with a chitosan coating. This stent has a radial support force of 195 cN per cm.
实施例2Example 2
将直径为0.3mm的聚对二氧杂环己酮纤维交叉编织成内径为6mm的具有网状结构的管状物，再将这一管状物套在外径为6mm的金属棒上，置于110℃烘箱中10分钟后，用内径为6.5mm的模具压合，纤维在交叉点相互粘结，再予以冷却、取下，得到纤维不发生松散的管状。Cross-braid polydioxanone fibers with a diameter of 0.3mm into a tubular object with an inner diameter of 6mm and a mesh structure, and then put this tubular object on a metal rod with an outer diameter of 6mm, and place it at 110°C After 10 minutes in the oven, press with a mold with an inner diameter of 6.5 mm, the fibers are bonded to each other at the intersection point, then cooled and removed to obtain a tubular shape in which the fibers do not become loose.
在经过热压合的的上述管状物表面涂复甲壳胺醋酸-水溶液，甲壳胺-醋酸-水溶液中甲壳胺的质量浓度为2％，醋酸与水的质量比为3∶100，涂复量为每厘米管状物0.035克，然后将涂复有甲壳胺醋酸-水溶液管状物置于20℃无水乙醇中，摇动5分钟后取出；再置于新鲜的20℃无水乙醇中，摇动5分钟后取出，以彻底洗脱醋酸；再在40℃真空烘箱中干燥20分钟，除去乙醇，即得到具有甲壳胺涂层的聚对二氧杂环己酮纤维支架。这种支架每cm的径向支撑力为239厘牛。Coat chitosan acetic acid-water solution on the surface of the above-mentioned tubes that have been hot-pressed, the mass concentration of chitosan in chitosan-acetic acid-water solution is 2%, the mass ratio of acetic acid to water is 3:100, and the coating amount is per centimeter 0.035 g of the tube, and then place the tube coated with chitosan acetic acid-water solution in 20°C absolute ethanol, take it out after shaking for 5 minutes; put it in fresh 20°C absolute alcohol, shake it for 5 minutes, take it out, and The acetic acid is completely eluted; and then dried in a vacuum oven at 40° C. for 20 minutes to remove ethanol to obtain a chitosan-coated polydioxanone fiber scaffold. This stent has a radial support force of 239 centinewtons per cm.
实施例3Example 3
将直径为0.6mm的聚丙交酯纤维交叉编织成内径为8mm的具有网状结构的管状物，再将这一管状物套在外径为8mm的金属棒上，置于80℃烘箱中15分钟后，纤维在交叉点相互粘结，再予以冷却、取下，得到纤维不发生松散的管状支架。这种支架每cm的径向支撑力为335厘牛。Cross-braid polylactide fibers with a diameter of 0.6mm into a tubular object with an inner diameter of 8mm and a mesh structure, and then put this tubular object on a metal rod with an outer diameter of 8mm, and place it in an oven at 80°C for 15 minutes. , the fibers are bonded to each other at the intersection points, and then cooled and removed to obtain a tubular scaffold in which the fibers do not loosen. This stent has a radial support force of 335 centinewtons per cm.
实施例4Example 4
将直径为0.4mm的聚乙交酯纤维交叉编织成内径为8mm的具有网状结构的管状物，再将这一管状物套在外径为8mm的金属棒上，置于80℃烘箱中15分钟后，纤维在交叉点相互粘结，再予以冷却、取下，得到纤维不发生松散的管状物。Cross-braid polyglycolide fibers with a diameter of 0.4mm into a tubular object with an inner diameter of 8mm and a mesh structure, and then put this tubular object on a metal rod with an outer diameter of 8mm, and place it in an oven at 80°C for 15 minutes Finally, the fibers are bonded to each other at the crossing points, and then cooled and removed to obtain a tubular object in which the fibers do not loosen.
在经过热处理的上述管状物表面涂复甲壳胺-醋酸-水溶液，甲壳胺-醋酸-水溶液中甲壳胺的质量浓度为4％，醋酸与水的质量比为5∶100，涂复量为每厘米管状物0.030克，然后将涂复有甲壳胺-醋酸-水溶液管状物置于30℃无水乙醇中，摇动5分钟后取出；再置于新鲜的30℃无水乙醇中，摇动5分钟后取出，以彻底洗脱醋酸；再在50℃真空烘箱中干燥15分钟，除去乙醇，即得到具有甲壳胺涂层的聚乙交酯纤维支架。这种支架每cm的径向支撑力为355厘牛。Coating chitosan-acetic acid-water solution on the surface of the above-mentioned tube after heat treatment, the mass concentration of chitosan in the chitosan-acetic acid-water solution is 4%, the mass ratio of acetic acid and water is 5: 100, and the amount of coating is per centimeter of tube 0.030 g, then place the tube coated with chitosan-acetic acid-water solution in 30°C absolute ethanol, shake it for 5 minutes and take it out; then place it in fresh 30°C absolute alcohol, shake it for 5 minutes and take it out to thoroughly Elution of acetic acid; drying in a vacuum oven at 50° C. for 15 minutes to remove ethanol to obtain a chitosan-coated polyglycolide fiber scaffold. This stent has a radial support force of 355 centinewtons per cm.
实施例5Example 5
将直径为0.1mm的丙交酯和乙交酯共聚酯纤维交叉编织成内径为3mm的具有网状结构的管状物，再将这一管状物套在外径为3mm的金属棒上，置于80℃烘箱中5分钟后，纤维在交叉点相互粘结，再予以冷却、取下，得到纤维不发生松散的管状支架。这种支架每cm的径向支撑力为150厘牛。Cross-braid lactide and glycolide copolyester fibers with a diameter of 0.1mm into a tubular object with an inner diameter of 3mm and a mesh structure, and then put this tubular object on a metal rod with an outer diameter of 3mm, and place it on the After being placed in an oven at 80°C for 5 minutes, the fibers are bonded to each other at the intersection points, and then cooled and removed to obtain a tubular scaffold without loose fibers. This stent has a radial support force of 150 centinewtons per cm.
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