CN102553084B - Phototherapy device - Google Patents

Abstract

The embodiment of the present invention discloses a phototherapy device, comprising: a light source, used to transmit light with a fixed wavelength to the light guide system, including receiving light with a fixed wavelength from a filter device and converting the light with a fixed wavelength The light of the wavelength is transmitted into the light guide system; the light guide system is used to enter the body of the patient to be treated under the control of the control system, and guide the light with a fixed wavelength introduced by the light source to the The lighting refraction system; the control system is used to control the light guide system to enter the body of the patient to be treated, so that the lighting refraction system located at the front end of the light guide system reaches the lesion in the patient; the lighting refraction system is used to guide the light guide system The light with a fixed wavelength guided by the light guide system uniformly irradiates the lesion in the patient's body. The tube-shaped continuous phototherapy device applied in the cavity provided by the present invention has tube-shaped LED packaging and light path design based on cavity organs, and can provide uniform cavity irradiation.

Description

A phototherapy device

technical field

The invention relates to the field of medical equipment, in particular to a phototherapy device.

Background technique

Photodynamic therapy (Photodynamic Therapy, PDT), formerly known as photoradiation therapy (Photoradiation Therapy, PRT), photochemotherapy (Photochemical Therapy, PCT), is a new technology that uses light for disease diagnosis and treatment. The clinical application of PDT can be divided into photodiagnosis (also known as fluorescence diagnosis) and phototherapy. Clinically, photodynamic therapy usually only refers to light therapy, while photodynamic diagnosis is called fluorescence diagnosis. Phototherapy is to irradiate the surface of the human body or the surface of the cavity with a spectrum of a specific band. Through the photothermal composite effect, it can effectively kill the diseased cells and tissues, coagulate the mucosal tissues, coagulate and block the blood vessels, and achieve the purpose of healing.

Photodynamic therapy is the synergistic effect of specific wavelengths of light and photosensitizers to make oxygen molecules in cells generate free radicals and single oxygen atoms, causing cytotoxicity and achieving the effect of treating diseases. At present, photodynamic therapy has been successfully applied in the treatment of skin diseases and tumors, such as actinic keratosis, basal cell carcinoma, Bowen's disease, etc. The most well-known application is the treatment of acne. Blue light irradiation of Propionibacterium acnes can cause the endogenous porphyrin to undergo a photochemical reaction to generate singlet oxygen, thereby killing the bacteria and achieving the effect of treating acne. More and more studies have proved that many bacteria, such as Gram-positive Staphylococcus aureus, Gram-negative Porphyromonas, Prevotella, Haemophilus, etc., can be killed by irradiation with specific wavelengths , such as 405nm light can kill Helicobacter pylori, 617nm light can kill Haemophilus parainfluenzae, 664nm light can kill Staphylococcus aureus, etc.

Photodynamic therapy is more and more widely used in medicine. So far, many hospitals have used photodynamic therapy to diagnose and treat tumors and infectious diseases clinically. For example, in the treatment of infectious diseases (such as skin diseases), the diagnosis and treatment of photodynamic therapy has achieved good results. Compared with traditional treatment methods, the advantage of photodynamic therapy is that it hardly leaves scars, and it is relatively easy to implement for lesions with large area, large number, or unclear boundaries, and it is also suitable for those who are unable or unwilling to accept traditional treatment. Another option. Side effects are also usually mild. Red light, blue light and yellow light with high purity and high power density can also change cell structure and kill bacteria.

Recent studies have shown that a variety of pathogenic bacteria in the human body (helicobacter pylori is the most prominent) can be killed by visible light, and the light wave with the best sterilization effect is good red and blue light. The killing mechanism of Helicobacter pylori is based on the fact that it can produce an endogenous photosensitizer "porphyrin" in its body. This substance has a strong absorption peak for light waves in the range of 405+/-25 nanometers. There are smaller absorption peaks at 550, 570 and 655 nm. The "porphyrin" after absorbing light waves undergoes a chemical de-excitation reaction, which can generate a large amount of active oxygen, the most important of which is singlet oxygen. Active oxygen can interact with a variety of biological macromolecules, damage cell structure or affect cell function, thus produce a killing effect.

Visible light transmits enough energy in these narrow wavelength ranges to kill most bacteria. And the light wave killing effect is remarkable, not only effective along the surface, but also has a good curative effect under the surface. The depth at which different light penetrates into tissues varies with the wavelength, and the longer the wavelength, the deeper the penetration. Light waves of 400 nanometers can penetrate about 1mm, while light waves of 650 nanometers can penetrate about 3mm or more. Therefore, light waves of different wavelengths can be selected according to the desired penetration depth to achieve the desired treatment depth. The effective wavelength for killing Helicobacter pylori is 400 nanometers. In addition, multicolored rays provide effective and deeper healing. Generally, this treatment effect can kill 99%-99.9% of bacteria, and the host's own immune system is also sufficient to kill the remaining bacteria.

At present, light sources used for photodynamic therapy generally use fluorescent lamps, incandescent lamps, LEDs, lasers, and chemiluminescence sources. Generally, 1 to 2 light sources are set by using a method similar to the light source of an endoscope. But, the shortcoming of this phototherapy apparatus is very obvious. Its main defects are as follows: 1. The light source is single and the irradiation is uneven; 2. The irradiation angle of the light source is limited and cannot reach 360° irradiation; 3. In order to achieve a certain irradiation intensity, the irradiation area is concentrated into one spot, which is not suitable for large areas Treatment. In order to solve the above problems, some phototherapy instruments use spherical or elliptical airbags in the endoscope to expand the cavity to expand the field of view, but due to the limitation of the light source, the irradiation range is still a spot. At present, there is also a photodynamic therapy lamp which is a luminous body composed of LED arrays, and the total luminous power is increased, but it can only be used outside the body. Therefore, the above-mentioned problems have not been fundamentally solved.

Contents of the invention

The technical problem to be solved by the embodiments of the present invention is to provide a tubular continuous phototherapy device applied in the cavity, the phototherapy device is a new type of medical device for full-channel treatment or an accessory of existing endoscopic equipment , the light therapy device has a tube-shaped LED package and light path design based on a hollow organ, and can provide uniform intracavity irradiation.

In order to solve the above technical problems, an embodiment of the present invention provides a phototherapy device applied in the cavity, including: a light source, a control system, a light guide system, and an illumination refraction system;

A light source, used to transmit light with a fixed wavelength into the light guide system, including receiving light with a fixed wavelength from the filter device and transmitting the light with a fixed wavelength into the light guide system;

A light guide system, used to enter the body of the patient to be treated under the control of the control system, and guide the light with a fixed wavelength introduced by the light source to the illumination refraction system;

A control system, used to control the light guide system to enter the body of the patient to be treated, so that the illumination refraction system located at the front end of the light guide system reaches the lesion in the patient;

The illumination refraction system is used to uniformly irradiate the light with a fixed wavelength guided by the light guide system on the lesion in the patient's body.

Wherein, the phototherapy device also includes:

The spectrum color matching system is used to select different wavelength spectrums for color matching according to the patient's lesions, and use them as the irradiation light source to kill the pathogenic bacteria at the lesions. The wavelength range of the spectrum includes: 360nm to 420nm.

Wherein, the light source includes: an illumination light module and a treatment light module;

an illumination light module, used to provide illumination for the endoscope at the front end of the phototherapy device;

The treatment light module is used to transmit light with a fixed wavelength to the light guide system for treating lesions in the patient's body.

Wherein, the therapeutic light module includes:

An LED light source is used to generate or receive light with a fixed wavelength from the filter device; the light source adopts a tubular LED;

a light detector for detecting light output conditions;

A control circuit, coupled to the power supply of the LED light source, is used to adjust the brightness of the LED light source and control the operation of the modulation component according to the detection signal of the photodetector;

A modulating component, configured to adjust the duration of each illumination on the patient's lesion and the interval between two illuminations under the control of the control circuit;

A filter wheel, used to control the type and wavelength of light passing through the filter wheel; the type of light includes ultraviolet light, infrared light, and visible light;

a light intensity detector for detecting the light intensity transmitted from the filter wheel to the patient, and determining the dose for the patient based on the light intensity;

An optical spectrum analyzer for receiving and analyzing the light reflected from the patient's lesion.

Wherein, the illumination light module includes:

The first primary color light semiconductor light source is used to emit the first primary color light;

The second primary color light semiconductor light source is used to emit the second primary color light;

Converging lens, located on the optical path of the first primary color light and the second primary color light, for converging the first primary color light and the second primary color light;

An optical fiber with one end at the focal point of the converging lens and the other end connected to the endoscope.

Wherein, the illumination refraction system guides the light from the light source to the surface of the illuminant through a bundle of optical fibers, and a prism is arranged at the end of each optical fiber, and the light is evenly diffused to the surrounding through the function of the prism, reaching the surface of the lumen/deep tissue; or

A reflective film is placed at the end of the optical fiber to transmit a part of the light, and the other part of the light is evenly diverged to reach the lumen surface/deep tissue; or

Corresponding light channels are set on the surface of the illuminant, so that the light can be evenly diffused through the light channels and reach the surface/deep tissue of the lumen.

Wherein, the phototherapy device also includes: a balloon;

The balloon structure includes: a tube body, a gastric balloon and/or an esophageal balloon; one end of the gastric balloon and/or esophageal balloon close to the tube body communicates with the tube body, and the tube body is used for feeding the gastric balloon and/or the esophageal balloon Inflate/deflate, and extract esophageal fluid, gastric juice;

The gastric balloon and/or the esophageal balloon are used to fix the phototherapy device relative to the patient cavity and prevent stomach and esophageal bleeding after entering the patient cavity with the phototherapy device.

Wherein, the length of the esophageal air bag is 8-12 cm.

Wherein, the phototherapy device further includes an accessory inlet, which is used for the auxiliary and therapeutic device to enter the patient's body through the opening.

Wherein, the phototherapy device enters the patient's body through the patient's oral cavity or nasal cavity.

The phototherapy device provided by the embodiment of the present invention can completely cover any infected area for phototherapy, and provide light irradiation with nearly equal optical density, which solves the problem that spot-type irradiation devices cannot uniformly irradiate a large area, and at the same time effectively reduces edema at the inflammatory site Congestion, improve microcirculation, promote tissue repair and healing, and solve the problem of drug-resistant bacterial intracavitary infection that cannot be cured. The phototherapy device provided by the embodiments of the present invention has a short course of medication, low predictable complications, and safety. And has a histocompatible balloon design.

Description of drawings

In order to more clearly illustrate the technical solutions in the embodiments of the present invention or the prior art, the following will briefly introduce the drawings that need to be used in the description of the embodiments or the prior art. Obviously, the accompanying drawings in the following description are only These are some embodiments of the present invention. Those skilled in the art can also obtain other drawings based on these drawings without creative work.

FIG. 1 is a schematic structural view of the first embodiment of the phototherapy device provided by the present invention;

Fig. 2 is a schematic structural diagram of the second embodiment of the phototherapy device provided by the present invention;

Figure 3 is a schematic diagram of setting a prism at the end of the optical fiber, and the light is evenly diffused to the surrounding through the effect of the prism;

Fig. 4 is a schematic diagram of setting a light channel on the surface of the illuminant to make the light evenly diffused;

Figure 5 is a schematic diagram of the optical path of a single LED;

Figure 6 is a schematic diagram of the illumination of a single LED;

Fig. 7 is a schematic diagram of illumination of multiple LEDs;

8 is a schematic diagram of the distribution of multiple LEDs on the plane receiving surface;

Fig. 9 is a schematic diagram when the illuminance of the receiving surface reaches a relatively good uniformity;

Fig. 10 is a schematic structural diagram of the third embodiment of the phototherapy device provided by the present invention.

Detailed ways

The phototherapy device provided by the embodiment of the present invention can completely cover any infected area for phototherapy, and provide light irradiation with nearly equal optical density, which solves the problem that spot-type irradiation devices cannot uniformly irradiate a large area, and at the same time effectively reduces edema at the inflammatory site Congestion, improve microcirculation, promote tissue repair and healing, and solve the problem of drug-resistant bacterial intracavitary infection that cannot be cured. The phototherapy device provided by the embodiments of the present invention has a short course of medication, low predictable complications, and safety. And has a histocompatible balloon design.

The phototherapy device provided by the present invention mainly includes the following parts: 1. Spectral color matching system; 2. Light sources that can emit specific wavelengths (such as 420nm, 850nm and 940nm); 3. Light guide system; 4. Intracavity lighting refraction system ; 5, auxiliary treatment system. The device provided by the present invention can be used as an independent treatment device, or can be used in conjunction with a traditional endoscope, or used as an accessory of a traditional endoscope, and the principle is the same. For the convenience of description, various embodiments of the present invention are described by taking the case where the phototherapy device cooperates with a traditional endoscope as an example.

The following will clearly and completely describe the technical solutions in the embodiments of the present invention with reference to the accompanying drawings in the embodiments of the present invention. Obviously, the described embodiments are only some, not all, embodiments of the present invention. Based on the embodiments of the present invention, all other embodiments obtained by persons of ordinary skill in the art without creative efforts fall within the protection scope of the present invention.

Referring to FIG. 1 , it is a schematic structural diagram of the first embodiment of the phototherapy device provided by the present invention. As shown in the figure, the device includes but not limited to: a light source 1 , a control system 2 , a light guide system 3 and an illumination refraction system 4 .

The light source 1 is used to transmit light with a fixed wavelength to the light guide system 3, including receiving light with a fixed wavelength from the filter device, and transmitting the light with a fixed wavelength to the light guide system 3 middle.

The light guide system 3 is used to enter the body of the patient to be treated under the control of the control system, and guide the light with a fixed wavelength introduced by the light source 1 to the illumination refraction system 4 .

The control system 2 is used to control the light guiding system 3 to enter the body of the patient to be treated, so that the illumination refracting system 4 located at the front end of the light guiding system 3 reaches the lesion in the patient.

The illumination refraction system 4 is used to uniformly irradiate the light with a fixed wavelength guided by the light guide system 3 on the lesion in the patient's body.

The phototherapy device provided by the embodiment of the present invention can completely cover any infected area for phototherapy, and provide light irradiation with nearly equal optical density, which solves the problem that spot-type irradiation devices cannot uniformly irradiate a large area, and at the same time effectively reduces edema at the inflammatory site Congestion, improve microcirculation, promote tissue repair and healing, and solve the problem of drug-resistant bacterial intracavitary infection that cannot be cured. The phototherapy device provided by the embodiments of the present invention has a short course of medication, low predictable complications, and safety.

Referring to FIG. 2 , it is a schematic structural diagram of the second embodiment of the phototherapy device provided by the present invention. In this embodiment, the structure and functions of the components of the phototherapy device will be described in more detail. As shown in the figure, the phototherapy device includes: a spectral color matching system 5 , a light source 1 , a light guide system 3 , a control system 2 , and an illumination refraction system 4 .

The spectrum color matching system 5 is used to select different wavelength spectra for color matching according to the patient's lesion, and use it as an irradiation light source to kill the pathogenic bacteria at the lesion. The wavelength range of the spectrum includes: 360nm to 420nm. Many studies have proved that many bacteria can be killed by irradiation of specific wavelengths. For example, 405nm light can kill Helicobacter pylori, 617nm light can kill Haemophilus parainfluenzae, and 664nm light can kill Aureus aureus. cocci etc. In this device, we use the 360nm-420nm spectrum for color matching, and use it as a light source to kill bacteria in the gastrointestinal tract.

The light source 1 is used to transmit light with a fixed wavelength to the light guide system 3, including receiving light with a fixed wavelength from the filter device, and transmitting the light with a fixed wavelength to the light guide system 3 middle. More specifically, the light source includes: a treatment light module and an illumination light module. The treatment light module is used to transmit light with a fixed wavelength to the light guide system 3 for treating lesions in the patient's body. The illumination light module is used to provide illumination for the endoscope at the front end of the phototherapy device.

Further, the treatment light module includes: LED light source, light detector, control circuit, modulation component, filter wheel, light intensity detector and spectrum analyzer.

The LED light source is used to generate or receive light with a fixed wavelength from the filter device; the light source adopts a tubular LED, which is a light-emitting diode semiconductor solid-state light source, and there is no gap between the light-emitting surface and the surface. The surface of the LED light source is covered with biocompatible silica gel, which has biological properties and will not reduce its performance and service life due to direct combination with biological systems. Biocompatible silicone rubber has good biocompatibility, non-irritating to human tissue, non-toxic, non-allergic reaction, and very little rejection of the body; it has good physical and chemical properties, and can be used in contact with body fluids and tissues. It maintains its original elasticity and softness and is not degraded. It is a fairly stable inert substance. The LED light source wrapped with biocompatible silica gel can withstand high temperature, can be sterilized, is easy to process and shape, easy to process and engrave, and is easy to use.

The LED light source is composed of multiple independent LEDs. Through local series connection and overall parallel connection, the brightness required for treatment can be achieved, and personalized treatment can be implemented, that is, different irradiation of different parts can be set according to the specific conditions of the affected part of the patient through program control. strength. The implementation of this function also depends on the hardness of the pipe body, the length and the cooperation of the scale on the outer surface of the pipe. This design uses materials with moderate hardness to make the tube body, so that it can not only smoothly enter the curved pipeline in the patient's body and reduce the pain of the patient, but also fully transmit the operator's strength to make the operation in place. The length of the tube body will be designed according to the standard of the human body, and can also be designed into tubes of different thicknesses according to the irradiation intensity required for treatment. The thinner ones can be designed to a corresponding length by considering the way of entering through the nose, and the thicker ones can be designed through the mouth. Enter.

A light detector for detecting light output conditions. More specifically, a light detector is coupled to the light-transmitting liquid container for detecting light output conditions in the light-transmitting liquid.

The control circuit, coupled to the LED light source power supply, can adjust the brightness of the LED light source according to the detection signal of the photodetector, and control the modulation component at the same time, thereby providing the first stage of using light to the patient and not using light to the patient. For the second phase of the patient, and such that the illumination within the first phase is pulsed or such that the first phase is always longer in time than the second phase. The control circuit is connectable to an external computer for storing a database and from which the user can enter commands and data, receive data therefrom, which data is modulated with said first phase, second phase and during the first phase of illumination on the patient related to the frequency or pulse.

The modulating component is used to adjust the duration of each illumination on the lesion of the patient and the interval between two illuminations under the control of the control circuit. The modulation means includes a pulse width modulation circuit, a first chopping element and a second chopping element for modulating the illumination to provide a treatment cycle consisting of one or more cycles, wherein each cycle of the plurality of cycles includes a The second stage, and the first stage immediately following the second stage. During the first phase, light is applied to the patient, and during the second phase, no light is applied to the patient. The modulating means is also for pulsating the light applied in each first phase to provide pulsed light to the patient.

The filter wheel is used to control the type and wavelength of light passing through the filter wheel; the type of light includes ultraviolet light, infrared light, and visible light. More specifically, the filter wheel includes a first filter wheel and a second filter wheel, the first filter wheel has at least one filter element for transmitting ultraviolet light, one filter element for transmitting infrared light, A filter element to transmit visible light and a blocking region to block any transmission of light from the light source. The second filter wheel has a plurality of filter elements for selecting a specific wavelength band passing through the second filter wheel. Further, the first filter wheel and the second filter wheel include a driving device for rotating the filter wheel so that selected filter elements are aligned with the light source, thereby providing light of a desired wavelength. Preferably, the second filter wheel includes a tilting mechanism for tilting the filter wheel so as to shift the bandwidth provided by each filter element of the second filter wheel.

A light intensity detector is used to detect the intensity of light transmitted from the filter wheel to the patient, and to determine the dose for the patient based on the intensity of the light and the distance between the light guide and the patient during treatment of the patient.

An optical spectrum analyzer for receiving and analyzing light reflected from the patient's lesion through the fiber optic waveguide.

The illumination light module includes a first primary color light semiconductor light source for emitting first primary color light. The second primary color light semiconductor light source is used for emitting the second primary color light. The converging lens is located on the optical path of the first primary color light and the second primary color light, and is used for converging the first primary color light and the second primary color light. An optical fiber with one end at the focal point of the converging lens and the other end connected to the endoscope.

The use of semiconductor lasers as light sources can save energy consumption, reduce the diameter of the light transmission path to reduce the pain of patients, eliminate unnecessary heating of tissues in the lighting cavity, reduce the volume of the lighting source, and avoid replacement and maintenance of the light source; The module adopts the control device to switch and adjust the power of the primary color light source, which can realize colored lighting and facilitate the observation of lesions. Compared with the ordinary light source illumination and optical fiber bundle transmission of spontaneous radiation in the existing endoscope, the illumination light module provided by the present invention has high brightness and low heat, which makes the endoscope colorful and vivid, and can be adjusted according to the needs of observing lesions The laser output power of each laser is suitable for brightness, color and chromaticity.

The light guide system 3 is used to enter the body of the patient to be treated under the control of the control system, and guide the light with a fixed wavelength introduced by the light source 1 to the illumination refraction system 4 . The main body of the light guide system 3 is an optical fiber, which has the characteristics of uniform distribution of side scattered light intensity, wide illumination range, small energy loss, low cost, plasticity, certain bending, and uniform illumination in the cavity. Side-emitting optical fiber is also called full-body optical fiber, linear optical fiber, leaky optical fiber, large-diameter light guide, and even neon optical fiber. It not only transmits light from one end face of the fiber to the other, but also leaks light out of its cladding surface, making the fiber as a whole glow.

The light guide system 3 mainly uses optical fibers that are specially treated to allow uniform light leakage for light guide. In the optical fiber of the light guiding system 3 , scatterers are distributed in the core layer at the interface between the core layer and the cladding layer with different densities and depths. When guided light is transmitted in the optical fiber, part of the guided light will be evenly scattered out of the optical fiber from the side of the optical fiber by the scatterer. The uniformity of the scattered light intensity on the side of the fiber is achieved by changing the attenuation coefficient at different positions of the fiber, and the change of the attenuation coefficient is achieved by changing the density and depth of the scatterers at different positions of the fiber.

The control system 2 is used to control the light guiding system 3 to enter the body of the patient to be treated, so that the illumination refracting system 4 located at the front end of the light guiding system 3 reaches the lesion in the patient.

The illumination refraction system 4 is used to uniformly irradiate the light with a fixed wavelength guided by the light guide system 3 on the lesion in the patient's body. More specifically, the illumination refraction system guides the light from the light source to the surface of the illuminant through a bundle of optical fibers, and a prism is arranged at the end of each optical fiber, and the light is evenly diffused to the surrounding through the function of the prism, reaching the surface/deep part of the lumen tissue (as shown in Figure 3); or set a reflective film at the end of the optical fiber, so that part of the light is transmitted, and the other part of the light is evenly diverged to reach the lumen surface/deep tissue; or set a corresponding light channel on the surface of the illuminant , so that the light is evenly diffused through the optical channel, and reaches the surface/deep tissue of the lumen (as shown in FIG. 4 ).

Furthermore, there are many ways to realize that the lighting refraction system 4 can radiate light evenly, and this embodiment lists three of them:

The first is to use equal light intensity, as shown in Figure 5. The light distribution curve of a single LED is I=I0cosθ, and the following assumptions are made: 1. The light intensity of the corresponding point A directly above each LED is only affected by the LED and the two adjacent LEDs; 2. The center point B of the two LEDs The light intensity above is only affected by these two LEDs.

If the light intensity of A and B in Figure 5 is equal, it is approximately considered that the light intensity in the direction of the AB connection is uniform; the same conclusion is reached in the direction perpendicular to the AB connection; if the LEDs in the two directions are staggered And when both meet the requirement that the light intensity between the two points is equal, it is considered that the light intensity on the entire irradiated surface is uniform.

The second is to use equal illuminance, as shown in Figure 5. The light distribution curve of a single LED I=I0cosθ, make the following assumptions: 1. The illuminance of the corresponding point A directly above each LED is only affected by the LED and the two adjacent LEDs; 2. The illuminance above the center point B of the two LEDs Illumination is only affected by these two LEDs;

If the illuminance of points A and B in Figure 5 are equal, it is approximately considered that the illuminance in the direction of the AB connection is uniform; the same conclusion is reached in the direction perpendicular to the AB connection; if the LEDs in the two directions are staggered and distributed When both meet the requirement that the illuminance between two points is equal, it is considered that the light intensity on the entire irradiated surface is uniform.

The third is direct simulation. Figure 6 is a simulation diagram of a single LED, and Figure 7 is a simulation diagram of multiple LEDs. It can be seen from the figure that when the number of LEDs increases, the energy received by the middle part of the irradiation surface under the illumination of each LED is relatively uniform, and the distance between the LEDs should be adjusted appropriately. The spacing can make the energy distribution on the irradiation surface reach the most uniform level. Fig. 8 is a schematic diagram of distribution simulation of multiple LEDs on a plane receiving surface. As shown in the figure, the horizontal distance between two LEDs in the same row is d, and the vertical distance between two adjacent LEDs in the same row is h. By continuously adjusting the values of d and h, and through the simulation of the simulation software, a suitable value of d and h can be obtained, so that the illuminance uniformity of the receiving surface can reach a relatively good level, as shown in Figure 9.

The phototherapy device provided by the embodiment of the present invention can completely cover any infected area for phototherapy, and provide light irradiation with nearly equal optical density, which solves the problem that spot-type irradiation devices cannot uniformly irradiate a large area, and at the same time effectively reduces edema at the inflammatory site Congestion, improve microcirculation, promote tissue repair and healing, and solve the problem of drug-resistant bacterial intracavitary infection that cannot be cured. The phototherapy device provided by the embodiments of the present invention has a short course of medication, low predictable complications, and safety.

Referring to FIG. 10 , it is a schematic structural diagram of a third embodiment of a phototherapy device provided by the present invention. The phototherapy device provided in this embodiment also includes a light source 1, a light guide system 3, a control system 2, an illumination refraction system 4, and a spectral color matching system 5, and the structures and functions of the above components are basically the same as those of the phototherapy device provided in the previous embodiment. The same will not be repeated in this embodiment. The phototherapy device provided in this embodiment differs from the phototherapy device provided in the previous embodiment in that some new accessories or auxiliary devices are added. As shown in Figure 11, the phototherapy device provided in this embodiment except the light source 1 , light guide system 3, control system 2, lighting refraction system 4, spectral color matching system 5, also includes: balloon;

The balloon structure includes: a tubular body 6, a gastric balloon 7 and/or an esophageal balloon 8; one end of the gastric balloon 7 and/or esophageal balloon 8 close to the tubular body communicates with the tubular body 6, and the tubular body 6 is used for feeding the stomach Inflation/deflation of the external air bag 7 and/or esophageal air bag 8, and extraction of esophageal fluid and gastric juice. Gastric balloon 7 and/or esophageal balloon 8 are used to fix the phototherapy device relative to the patient cavity and prevent gastric and esophageal bleeding after they enter the patient cavity with the phototherapy device.

More specifically, an esophageal fluid extraction cavity is also opened in the tube body 6, and an esophageal fluid extraction tube is correspondingly installed at one end of the esophageal fluid extraction cavity, and an esophageal fluid extraction hole is opened on the side of the tube body adjacent to the esophageal balloon 8 , The esophageal fluid extraction hole, the esophageal fluid extraction cavity, and the esophageal fluid extraction tube are connected. In the middle of the gastric inflation tube and the middle of the esophageal inflation tube, there are connected respectively a gastric buffer air bag and an esophageal buffer air bag, which are elastic sacs. The increased esophageal fluid extraction chamber can avoid secondary infection caused by inhalation of secretions into the lungs; the buffer airbag can directly observe the inflation of the stomach and esophageal airbags and adjust them in time; it is also easy to change the syringe; the length of the esophageal airbag is 8-12 cm, It can reduce the pressure on the left bronchus and left atrium after the esophageal balloon is inflated, and it can also be used as an emergency device to prevent gastric and esophageal bleeding.

Further, the phototherapy device also includes an accessory inlet 9, which is used for auxiliary and therapeutic devices to enter the patient's body through this opening. Devices that can be used in conjunction with the phototherapy device provided by the present invention through the accessory inlet 9 include but are not limited to: an insertion system and a drug injection device.

Insertion system: The insertion system is equipped with an insertion assisting device that installs a first balloon on the insertion portion of the endoscope, guides the insertion portion to be inserted into a body cavity, and has a second balloon at its front end, and An end connector of a tube is connected to the balloon control device for supplying and suctioning air to the balloon and the second balloon. The insertion system connects the first pipeline communicated with the first balloon installed on the insertion part of the endoscope, the second pipeline communicated with the second balloon installed on the insertion aid, to the insertion part and the insertion aid The third pipeline for supplying lubricant between them is connected to the balloon control device, or the three pipelines are connected to the connector part of the endoscope between the external device and connected to the balloon control device, Therefore, the connection work with the balloon control device can be easily performed, and connection errors can be eliminated. The insertion system alternately inserts the insertion part of the endoscope and the insertion assisting device, and then inserts and observes the deep alimentary canal such as the small intestine or the large intestine.

Drug injection device: one end of the infusion tube is located at the bottom of the liquid storage bottle, and the other end is equipped with a drug spray head. The front end of the drug spray head has a spherical surface, and several spray holes are arranged on the spherical surface. An inflatable tube is plugged into the bottle cap of the liquid storage bottle, one end of the inflatable tube is located above the liquid level in the liquid storage bottle, and the other end is connected with an extruded inflatable bag. When performing anesthesia before surgery on the stomach or women's cervix and uterine cavity, insert the drug nozzle with a spherical surface into the stomach or cervix and uterine cavity, and then squeeze the air in the storage bottle by squeezing the inflatable bag to anesthetize the anesthesia The medicine liquid is evenly sprayed onto the stomach or the cervix and uterine cavity through the nozzle holes on the medicine nozzle, which reduces the pain of the patient. The structure is reasonable and practical, no special surgical instruments are needed, and the operation is simple.

Further, the phototherapy device provided by the present invention is provided with a sterile isolation sleeve on the endoscope. The sterile isolation sleeve is contained in the outer surface of the endoscope and is made of hard plastic or plexiglass or glass. The observation hole of the isolation sleeve corresponding to the endoscope is a transparent body with convex and concave rings similar to optical lenses. The part of the isolation sleeve that is inserted into the human body is transparent, and the isolation sleeve is provided with a bayonet slot corresponding to the optical fiber seat of the cavity mirror, and the transparent body part of the inner wall of the isolation sleeve is coated with an anti-fogging agent.

The phototherapy device provided by the embodiment of the present invention can completely cover any infected area for phototherapy, and provide light irradiation with nearly equal optical density, which solves the problem that spot-type irradiation devices cannot uniformly irradiate a large area, and at the same time effectively reduces edema at the inflammatory site Congestion, improve microcirculation, promote tissue repair and healing, and solve the problem of drug-resistant bacterial intracavitary infection that cannot be cured. The phototherapy device provided by the embodiments of the present invention has a short course of medication, low predictable complications, and safety.

Those of ordinary skill in the art can understand that all or part of the processes in the methods of the above embodiments can be implemented through computer programs to instruct related hardware, and the programs can be stored in a computer-readable storage medium. During execution, it may include the processes of the embodiments of the above-mentioned methods. Wherein, the storage medium may be a magnetic disk, an optical disk, a read-only memory (Read-Only Memory, ROM) or a random access memory (Random AccessMemory, RAM), etc.

The above disclosure is only a preferred embodiment of the present invention, which certainly cannot limit the scope of rights of the present invention. Therefore, equivalent changes made according to the claims of the present invention still fall within the scope of the present invention.

Claims (2)

1. A phototherapy device, characterized in that it comprises: a light source, a control system, a light guide system and an illumination refraction system; A light source, used to transmit light with a fixed wavelength into the light guide system, including receiving light with a fixed wavelength from the filter device and transmitting the light with a fixed wavelength into the light guide system; A light guide system, used to enter the body of the patient to be treated under the control of the control system, and guide the light with a fixed wavelength introduced by the light source to the illumination refraction system; A control system, used to control the light guide system to enter the body of the patient to be treated, so that the illumination refraction system located at the front end of the light guide system reaches the lesion in the patient; The illumination refraction system is used to uniformly irradiate the light with a fixed wavelength guided by the light guide system on the lesion in the patient's body. The illumination refraction system guides the light from the light source to the surface of the illuminant through a bundle of optical fibers. A prism is installed at the end of the optical fiber, through the function of the prism, the light is evenly diffused to the surrounding, reaching the surface of the lumen or deep tissue; or a reflective film is installed at the end of the optical fiber, so that part of the light is transmitted, and the other part of the light is evenly diverged to reach The surface of the lumen or the deep tissue; or a corresponding light channel is set on the surface of the illuminant, so that the light can be evenly diffused through the light channel and reach the surface of the lumen or the deep tissue. 2. phototherapy device as claimed in claim 1, is characterized in that, described phototherapy device also comprises: The spectrum color matching system is used to select different wavelength spectrums for color matching according to the patient's lesions, and use them as the irradiation light source to kill the pathogenic bacteria at the lesions. The wavelength range of the spectrum includes: 360nm to 420nm. 3. The phototherapy device according to claim 1, wherein the light source comprises: an illumination light module and a treatment light module; an illumination light module, used to provide illumination for the endoscope at the front end of the phototherapy device; The treatment light module is used to transmit light with a fixed wavelength to the light guide system for treating lesions in the patient's body. 4. The phototherapy device according to claim 3, wherein the treatment light module comprises: The LED light source is used to generate or receive light with a fixed wavelength from the filter device; the light source adopts a tubular LED; a light detector for detecting light output conditions; A control circuit, coupled to the power supply of the LED light source, used to adjust the brightness of the LED light source and control the operation of the modulation component according to the detection signal of the photodetector; A modulating component, configured to adjust the duration of each illumination on the patient's lesion and the interval between two illuminations under the control of the control circuit; A filter wheel, used to control the type and wavelength of light passing through the filter wheel; the type of light includes ultraviolet light, infrared light, and visible light; a light intensity detector for detecting the light intensity transmitted from the filter wheel to the patient, and determining the dose for the patient based on the light intensity; An optical spectrum analyzer for receiving and analyzing the light reflected from the patient's lesion. 5. The phototherapy device according to claim 3, wherein the illumination light module comprises: The first primary color light semiconductor light source is used to emit the first primary color light; The second primary color light semiconductor light source is used to emit the second primary color light; A converging lens, located on the optical path of the first primary color light and the second primary color light, is used to converge the first primary color light and the second primary color light; one end of the optical fiber is located at the focal point of the converging lens, and the other end is connected to the endoscope. 6. The phototherapy device according to claim 1, wherein the phototherapy device further comprises: a balloon; the balloon structure comprises: a tube body, a gastric balloon and/or an esophageal balloon; a gastric balloon and/or Or the end of the esophageal balloon close to the tube body communicates with the tube body, and the tube body is used to inflate or deflate the gastric balloon and/or esophageal balloon, and extract esophageal fluid and gastric juice; Gastric balloon and/or esophageal balloon are used to fix the phototherapy device relative to the patient cavity and prevent gastric and esophageal bleeding after it enters the patient cavity with the phototherapy device. 7. The phototherapy device according to claim 6, wherein the length of the esophageal balloon is 8-12 cm. 8. The phototherapy device according to claim 7, characterized in that, the phototherapy device further comprises an accessory inlet, which is used for assisting the therapeutic device to enter the patient's body through the accessory inlet. 9. The phototherapy device according to any one of claims 1 to 5, wherein the phototherapy device enters the patient's body through the patient's oral cavity or nasal cavity.