CN102552670A

CN102552670A - Preparation method for oral liquid capable of clearing heat and removing toxicity

Info

Publication number: CN102552670A
Application number: CN2010106054079A
Authority: CN
Inventors: 邹武斌
Original assignee: Jiangxi Jimin Kexin Group Co Ltd; Jiangxi Jimin Kexin Pharmaceutical Co Ltd
Current assignee: Jiangxi Jimin Kexin Group Co Ltd; Jiangxi Jimin Kexin Pharmaceutical Co Ltd
Priority date: 2010-12-27
Filing date: 2010-12-27
Publication date: 2012-07-11
Anticipated expiration: 2030-12-27
Also published as: CN102552670B

Abstract

The invention discloses a preparation method for oral liquid capable of clearing heat and removing toxicity, which comprises the following steps: according to a prescription dose specified by the pharmacopeia, taking 12 medicines of gypsum, honeysuckle, radix scrophulariae, dried rehmannia root, fructus forsythia, jasmine, Chinese violet, scutellaria baicalensis, radix gentianae, isatis root, rhizoma anemarrhenae and radix ophiopogonis; firstly extracting the honeysuckle by ethanol, filtering, and concentrating filtrate; decocting filter residue and other 11 medicines with water for two times; combining, filtering and concentrating decoction; adding the ethanol to ensure that the ethanol content is 65%; refrigerating for 48h; filtering, and concentrating; adding activated carbon and sodium benzoate; stirring to dissolve the activated carbon and the sodium benzoate; adding crane sugar, heating and cooling; adding the honeysuckle to extract the concentrated solution; stirring to dissolve the honeysuckle; adding water to the specified volume; and evenly mixing to obtain the oral liquid.

Description

A kind of method for preparing of QINGRE JIEDU KOUFUYE

Technical field

The present invention relates to a kind of Chinese medicinal preparation method, be specifically related to a kind of method for preparing of QINGRE JIEDU KOUFUYE, belong to field of traditional Chinese medicine pharmacy.

Background technology

QINGRE JIEDU KOUFUYE be by medical materials such as Flos Lonicerae, Radix Scutellariaes through extracting to such an extent that prepare burden behind the clear paste and process, have effects for removing toxic heat, diseases such as the flushed complexion that is used for generating heat due to the hyperactivity of toxic heat, irritated thirsty, laryngopharynx swelling and pain, influenza, upper respiratory tract infection are seen above-mentioned disease person.Existing QINGRE JIEDU KOUFUYE method for preparing: except that Flos Lonicerae, Radix Scutellariae, all the other Gypsum Fibrosum etc. ten flavor medical materials add water temperature earlier and soaked 1 hour, decoct secondary (after waiting to seethe with excitement, cold rnning Flos Lonicerae and Radix Scutellariae) slightly again, 1 hour for the first time; 40 minutes for the second time, filter, merging filtrate, filtrating is concentrated into relative density and is about 1.17 (80 ℃), gets clear paste; Add ethanol, make to contain alcohol amount and reach 65% ~ 70%, cold preservation 48 hours filters, and reclaims ethanol; Add 0.5% active carbon, heated 30 minutes, filter, add water to recipe quantity; Filter, fill, sterilization promptly gets.Method exists the interior Main Ingredients and Appearance chlorogenic acid extraction of Flos Lonicerae not exclusively now, thereby affects the treatment, and has waste medical material problem.

Summary of the invention

The object of the present invention is to provide a kind of effective extraction ratio that can improve the interior chlorogenic acid of Flos Lonicerae in the QINGRE JIEDU KOUFUYE, thereby improve the effect of QINGRE JIEDU KOUFUYE, reduce the waste of Chinese crude drug.Preparation technology of the present invention is convenient and practical, and is easy to control product quality, and the present invention realizes through following structure.

Method for preparing of the present invention is:

QINGRE JIEDU KOUFUYE, it is write out a prescription by weight:

80 parts of 107 parts of Radix Rehmanniae of 134 portions of Radix Scrophulariaes of 670 portions of Flos Loniceraes of Gypsum Fibrosum

67 parts of 67 parts of Radix Scutellariaes of 67 parts of Herba Gueldenstaedtiaes of 67 portions of Fructus Gardeniaes of Fructus Forsythiae

54 parts of 67 parts of Rhizoma Anemarrhenaes of 67 parts of Radix Isatidis of Radix Gentianae 54 parts of Radix Ophiopogonis

Step 1 is got Flos Lonicerae in the recipe quantity with 50-95% alcohol reflux 2 times, and each 1 hour, filter, reclaim ethanol, Flos Lonicerae slag and concentrated solution are subsequent use;

Step 2 is got and Gypsum Fibrosum, Radix Scrophulariae, Radix Rehmanniae, Fructus Forsythiae, Fructus Gardeniae, Herba Gueldenstaedtiae, Radix Gentianae, Radix Isatidis, the Rhizoma Anemarrhenae, Radix Ophiopogonis in the prescription is added water temperature and soaked 1 hour, be heated to boiling after, add the Radix Scutellariae of Flos Lonicerae slag and recipe quantity; Decoct twice, 1 hour for the first time, the 2nd time 40 minutes, filter; Merge to filter, mention liquid and concentrate, be about 1.17 to relative density, add ethanol; Make to contain alcohol amount and reach 65% ~ 70%, cold preservation 48 hours filters, and reclaims ethanol; Being concentrated into relative density is 1.25, adds 0.5% active carbon, heats 30 minutes; Add an amount of sodium benzoate in mentioning liquid, stir and to make dissolving, continuously add the appropriate amount of auxiliary materials post-heating and boil, filter, put cold;

Step 3, the liquid of getting in the step 2 of mentioning adds the Flos Lonicerae extraction concentrated solution in the step 1, stirs and makes its dissolving, adds water to recipe quantity, and mixing promptly gets.

Method for preparing of the present invention; Method for preparing with respect to existing QINGRE JIEDU KOUFUYE; Increased first step with the ethanol extraction Flos Lonicerae; This improvement has produced beyond thought effect: surveying chlorogenic acid contents in the product with high performance liquid chromatogram, is 1.5 times of chlorogenic acid content in the QINGRE JIEDU KOUFUYE that makes of prior art with chlorogenic acid contents in the prepared QINGRE JIEDU KOUFUYE of the present invention.Just the extraction ratio of chlorogenic acid is 1.5 times of existing technology of preparing in the QINGRE JIEDU KOUFUYE.

The specific embodiment

Embodiment one:

Prescription: Gypsum Fibrosum 670g Flos Lonicerae 134g Radix Scrophulariae 107g Radix Rehmanniae 80g

Fructus Forsythiae 67g Fructus Gardeniae 67g Herba Gueldenstaedtiae 67g Radix Scutellariae 67g

Radix Gentianae 67g Radix Isatidis 67g Rhizoma Anemarrhenae 54g 54g Radix Ophiopogonis

Method for making:

(1) extracting honeysuckle 134 g, with 70% ethanol 1200ml reflux, extract, 2 times, each 1 hour, filter, filtrate recycling ethanol to relative density 1.30, Flos Lonicerae slag and concentrated solution are subsequent use;

(2) get Gypsum Fibrosum, Radix Scrophulariae, Radix Rehmanniae, Fructus Forsythiae, Fructus Gardeniae, Herba Gueldenstaedtiae, Radix Gentianae, Radix Isatidis, the Rhizoma Anemarrhenae, Radix Ophiopogonis and add water temperature and soaked 1 hour, be heated to the boiling back and add the Flos Lonicerae slag and decoct twice with Radix Scutellariae, 1 hour first time, the 2nd time 40 minutes; Filter, merging filtrate, heating is concentrated into relative density and is about 1.17, adds ethanol; Make to contain alcohol amount and reach 65% ~ 70%, cold preservation 48 hours filters, and reclaims ethanol; Being concentrated into relative density is 1.25, adds the 5g active carbon, heats 30 minutes;

(3) add the 0.3g sodium benzoate in decocting liquid, stir and to make dissolving, continuously add 300ml simple syrup post-heating and boil, filter, put cold;

(4) the continuous Flos Lonicerae ethanol extraction concentrated solution that adds stirs and makes its dissolving, adds water to 1000ml, and mixing promptly gets.

Embodiment two:

Method for making:

(1) extracting honeysuckle 134 g, with 50% ethanol 1200ml reflux, extract, 2 times, each 1 hour, filter, filtrate recycling ethanol to relative density 1.25, Flos Lonicerae slag and concentrated solution are subsequent use;

(2) add Gypsum Fibrosum, Radix Scrophulariae, Radix Rehmanniae, Fructus Forsythiae, Fructus Gardeniae, Herba Gueldenstaedtiae, Radix Gentianae, Radix Isatidis, the Rhizoma Anemarrhenae, Radix Ophiopogonis water temperature and soaked 1 hour, be heated to the boiling back and add Flos Lonicerae slag and Radix Scutellariae decoction twice, 1 hour for the first time, the 2nd time 40 minutes; Filter, merging filtrate, heating is concentrated into relative density and is about 1.17, adds ethanol; Make to contain alcohol amount and reach 65% ~ 70%, cold preservation 48 hours filters, and reclaims ethanol; Being concentrated into relative density is 1.25, adds 0.6g steviosin, 5g active carbon, heats 30 minutes;

(3) add the 0.3g sodium benzoate in decocting liquid, stir and make dissolving, heated and boiled filters, and puts cold;

Claims

1. the method for preparing of a QINGRE JIEDU KOUFUYE; It is characterized in that the prescription of QINGRE JIEDU KOUFUYE (by weight) is: 54 parts of 67 parts of Rhizoma Anemarrhenaes of 67 parts of Radix Isatidis of 67 parts of Radix Gentianae of 67 parts of Radix Scutellariaes of 67 parts of Herba Gueldenstaedtiaes of 67 portions of Fructus Gardeniaes of 80 parts of Fructus Forsythiaes of 107 parts of Radix Rehmanniae of 134 portions of Radix Scrophulariaes of 670 portions of Flos Loniceraes of Gypsum Fibrosum 54 parts of Radix Ophiopogonis

Be prepared from according to the following steps:

Step 1 is got Flos Lonicerae in the recipe quantity with alcohol reflux 2 times, and each 1 hour, filter, reclaim ethanol, Flos Lonicerae slag and concentrated solution are subsequent use;

Step 2 is got and Gypsum Fibrosum, Radix Scrophulariae, Radix Rehmanniae, Fructus Forsythiae, Fructus Gardeniae, Herba Gueldenstaedtiae, Radix Gentianae, Radix Isatidis, the Rhizoma Anemarrhenae, Radix Ophiopogonis in the prescription is added water temperature and soaked 1 hour, be heated to boiling after, add the Radix Scutellariae of Flos Lonicerae slag and recipe quantity, decoct twice; 1 hour for the first time, the 2nd time 40 minutes, filter, merge and filter, be concentrated into relative density and be about 1.17; Add ethanol, make to contain alcohol amount and reach 65% ~ 70%, cold preservation 48 hours filters, and reclaims ethanol; Being concentrated into relative density is 1.25, adds 0.5% active carbon, heats 30 minutes, adds an amount of sodium benzoate in mentioning liquid; Stirring makes dissolving, adds the appropriate amount of auxiliary materials post-heating and boils, and filters, and puts cold;

Step 3, the Flos Lonicerae concentrated solution of getting step 1 extraction adds mentioning in the liquid of step 2, stirs and makes its dissolving, adds water to 1000ml, and mixing promptly gets.