CN102551917B - Artificial fallopian tube and preparation method thereof - Google Patents
Artificial fallopian tube and preparation method thereof Download PDFInfo
- Publication number
- CN102551917B CN102551917B CN201110401167.5A CN201110401167A CN102551917B CN 102551917 B CN102551917 B CN 102551917B CN 201110401167 A CN201110401167 A CN 201110401167A CN 102551917 B CN102551917 B CN 102551917B
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- CN
- China
- Prior art keywords
- artificial
- braided tube
- oviduct
- horn
- polyster fibre
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Links
- 210000003101 oviduct Anatomy 0.000 description 23
- 239000000835 fiber Substances 0.000 description 15
- YCKRFDGAMUMZLT-UHFFFAOYSA-N Fluorine atom Chemical compound [F] YCKRFDGAMUMZLT-UHFFFAOYSA-N 0.000 description 7
- 229920006237 degradable polymer Polymers 0.000 description 7
- 239000003814 drug Substances 0.000 description 7
- 125000005396 acrylic acid ester group Chemical group 0.000 description 6
- 238000001035 drying Methods 0.000 description 6
- 239000000839 emulsion Substances 0.000 description 6
- 229910052731 fluorine Inorganic materials 0.000 description 6
- 239000011737 fluorine Substances 0.000 description 6
- 230000001680 brushing effect Effects 0.000 description 5
- 238000007731 hot pressing Methods 0.000 description 5
- 239000004021 humic acid Substances 0.000 description 5
- 238000002360 preparation method Methods 0.000 description 4
- 229920001661 Chitosan Polymers 0.000 description 3
- 102000002322 Egg Proteins Human genes 0.000 description 3
- 108010000912 Egg Proteins Proteins 0.000 description 3
- 230000000903 blocking effect Effects 0.000 description 3
- OBNCKNCVKJNDBV-UHFFFAOYSA-N ethyl butyrate Chemical compound CCCC(=O)OCC OBNCKNCVKJNDBV-UHFFFAOYSA-N 0.000 description 3
- 210000004681 ovum Anatomy 0.000 description 3
- 229920000747 poly(lactic acid) Polymers 0.000 description 3
- 229920001610 polycaprolactone Polymers 0.000 description 3
- 239000004626 polylactic acid Substances 0.000 description 3
- 150000002148 esters Chemical class 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 239000004632 polycaprolactone Substances 0.000 description 2
- 206010001233 Adenoma benign Diseases 0.000 description 1
- 244000043261 Hevea brasiliensis Species 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 208000002938 adenomyoma Diseases 0.000 description 1
- 230000000721 bacterilogical effect Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 229920001577 copolymer Polymers 0.000 description 1
- 230000002526 effect on cardiovascular system Effects 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 208000000509 infertility Diseases 0.000 description 1
- 230000036512 infertility Effects 0.000 description 1
- 231100000535 infertility Toxicity 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 238000005461 lubrication Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 229920003052 natural elastomer Polymers 0.000 description 1
- 229920001194 natural rubber Polymers 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 210000004291 uterus Anatomy 0.000 description 1
Landscapes
- Materials For Medical Uses (AREA)
- Prostheses (AREA)
Abstract
本发明涉及一种人工输卵管及其制备方法，人工输卵管为涤纶纤维编织管，编织管内层为氟树脂层，含防粘连药的可降解的聚合物涂层膜位于编织管的端口处。制备方法，包括：(1)将涤纶纤维编织成涤纶纤维编织管，于140～160℃热定型；(2)用含氟的丙烯酸酯乳液涂刷上述编织管内层，然后干燥得到内有氟树脂层的编织管；(3)将防粘连药和可降解的聚合物配成溶液，涂布到喇叭状的模具上，干燥得喇叭状膜，把喇叭状膜分别放入两个喇叭口的端部，经热压得人工输卵管。本发明可以替代已经堵塞坏死的部分输卵管，接入到原输卵管部位以保证卵子的通行流畅；缝合口机械强度大，不易撕裂。
The invention relates to an artificial fallopian tube and a preparation method thereof. The artificial fallopian tube is a polyester fiber braided tube, the inner layer of the braided tube is a fluororesin layer, and a degradable polymer coating film containing anti-adhesion medicine is located at the end of the braided tube. The preparation method includes: (1) braiding polyester fibers into a polyester fiber braided tube, and heat-setting at 140-160°C; (2) coating the inner layer of the braided tube with fluorine-containing acrylate emulsion, and then drying to obtain a fluorine-containing resin (3) Make a solution of anti-adhesion drug and degradable polymer, apply it on the horn-shaped mold, dry it to get the horn-shaped film, put the horn-shaped film into the ends of the two horn mouths respectively Department, the artificial fallopian tube was obtained by hot pressing. The invention can replace part of the fallopian tubes that have been blocked and necrotic, and can be connected to the original fallopian tubes to ensure smooth passage of eggs; the suture port has high mechanical strength and is not easy to tear.
Description
Technical field
The invention belongs to medical department of obstetrics and gynecology field, particularly a kind of artificial oviduct and preparation method thereof.
Background technology
At present, in the infertility caused by women's pathologic problems, considerable part is had to be blocked by fallopian tube adhesion and cause.The generation of adhesion mainly fallopian tube extensive inflammation causes.Before adhesion does not also block completely, the methods such as anti support can be adopted to carry out Film with Preventing Adhesion blocking.For the patient of fallopian tube adhesion blocking, be just difficult to get through again.
The artificial organ of artificial oviduct to be one end of being made by natural rubber with cover, one end be equipped with check valve, in order to replace, Oviduct Development is complete, cornua uteri adenomyoma or cause the fallopian tube that blocks because of bacteriological infection etc., and the research work of current artificial oviduct is also very immature.
Summary of the invention
Technical problem to be solved by this invention is to provide a kind of artificial oviduct and preparation method thereof, and this fallopian tube can substitute and block downright bad part fallopian tube, is linked into former fallopian tube position to ensure the current smoothness of ovum; Sew up mouth mechanical strength large, not easily tear.
A kind of artificial oviduct of the present invention, described artificial oviduct is polyster fibre braided tube, and braided tube internal layer is fluororesin layer, and the degradable polymer coated film containing anti medicine is positioned at the port of braided tube.
The specification of described polyster fibre is 6 ~ 300d/2 ~ 100F.
Described polyster fibre braided tube mid diameter is 2 ~ 3mm, horn mouth diameter 2 ~ 3mm, and length is 2 ~ 3mm.
Described fluororesin is formed by fluorine-containing acrylic acid ester emulsion drying.
The weight ratio of described anti medicine and degradable polymer is 1 ~ 3: 97 ~ 99.
Described anti medicine is chitosan or humic acids.
Described degradable polymer is one or more copolymers formed in polylactic acid, polycaprolactone, poly butyric ester.
The preparation method of a kind of artificial oviduct of the present invention, comprising:
(1) polyster fibre is woven into polyster fibre braided tube, in 140 ~ 160 DEG C of thermal finalizations;
(2) with the above-mentioned braided tube internal layer of fluorine-containing acrylic acid ester emulsion brushing, then drying has the braided tube of fluororesin layer in obtaining;
(3) be 1 ~ 3: 97 ~ 99 for anti medicine and degradable polymer wiring solution-forming by weight ratio, be applied on trumpet-shaped mould, dry horn-like film, puts into two bell-mouthed ends respectively horn-like film, obtains artificial oviduct through hot pressing.
Polyster fibre braided tube is foolproof material, for artificial cardiovascular manufacture.The lubricity that fluor resin coating has had and chemistry, biologically inert are foolproof materials.The degradable polymer containing anti medicine is also scribbled at oviducal two ends of the present invention internal layer, this coated film slightly extends pipe, degradable polymer is progressively degraded in vivo, discharge anti medicine while excreting, can prevent from causing new blocking at stitching interface because of hamartoplasia.
beneficial effect
(1) the present invention can substitute and block downright bad part fallopian tube, is linked into former fallopian tube position to ensure the current smoothness of ovum;
(2) feature of the present invention sews up mouth mechanical strength greatly, not easily tears; Inside pipe wall lubrication travels forward with favourable ovum, uses the women of artificial oviducal former salpingemphraxis, can become pregnant with the same intrauterine at oneself of normal women.
Accompanying drawing explanation
Fig. 1 is structural representation of the present invention; Wherein 1 is polyster fibre braided tube, and 2 is fluororesin layer, and 3 is the degradable polymer coated film containing anti medicine.
Detailed description of the invention
Below in conjunction with specific embodiment, set forth the present invention further.Should be understood that these embodiments are only not used in for illustration of the present invention to limit the scope of the invention.In addition should be understood that those skilled in the art can make various changes or modifications the present invention, and these equivalent form of values fall within the application's appended claims limited range equally after the content of having read the present invention's instruction.
Embodiment 1
Be woven into the polyster fibre of 50d/10F that mid diameter is 2mm, horn mouth diameter is 5mm, length is the polyster fibre braided tube of 25mm, to shape at 150 DEG C of temperature, then with fluorine-containing acrylic acid ester emulsion brushing braided tube internal layer, then dry obtain in have the braided tube of fluororesin layer.Be applied on trumpet-shaped mould with the solution containing 2 grams of humic acidss, 98 grams of polycaprolactones, drying obtains the horn-like film that humic acids and polycaprolactone are 2: 98, two these films is put into two flare end respectively, obtains artificial oviduct through hot pressing.
Embodiment 2
Be woven into the polyster fibre of 6d/100F that mid diameter is 3mm, horn mouth diameter is 6mm, length is the polyster fibre braided tube of 30mm, to shape at 140 DEG C of temperature, then with fluorine-containing acrylic acid ester emulsion brushing braided tube internal layer, then dry obtain in have the braided tube of fluororesin layer.Be applied on trumpet-shaped mould with the solution containing 1 gram of humic acids, 99 grams of polylactic acid, drying obtains the horn-like film that humic acids and polylactic acid are 1: 99, two these films is put into two flare end respectively, obtains artificial oviduct through hot pressing.
Embodiment 3
Be woven into the polyster fibre of 300d/2F that mid diameter is 3mm, horn mouth diameter is 6mm, length is the polyster fibre braided tube of 24mm, to shape at 160 DEG C of temperature, then with fluorine-containing acrylic acid ester emulsion brushing braided tube internal layer, then dry obtain in have the braided tube of fluororesin layer.Be applied on trumpet-shaped mould with the solution containing 3 grams of chitosan, 97 grams of poly butyric esters, drying obtains the horn-like film that chitosan and poly butyric ester are 3: 97, two these films is put into two flare end respectively, obtains artificial oviduct through hot pressing.
Embodiment 4
Be woven into the polyster fibre of 15d/60F that mid diameter is 2mm, horn mouth diameter is 5mm, length is the polyster fibre braided tube of 30mm, to shape at 145 DEG C of temperature, then with fluorine-containing acrylic acid ester emulsion brushing braided tube internal layer, then dry obtain in have the braided tube of fluororesin layer.Be applied on trumpet-shaped mould with the solution containing 3 grams of humic acidss, 97 grams of poly butyric esters, drying obtains the horn-like film that humic acids and poly butyric ester are 3: 97, two these films is put into two flare end respectively, obtains artificial oviduct through hot pressing.
Claims (7)
1. an artificial oviduct, is characterized in that: described artificial oviduct is polyster fibre braided tube, and braided tube internal layer is fluororesin layer, and the degradable polymer coated film containing anti medicine is positioned at the port of braided tube; Wherein, described polyster fibre braided tube mid diameter is 2 ~ 3mm, horn mouth diameter 4 ~ 6mm, and length is 20 ~ 30mm.
2. a kind of artificial oviduct according to claim 1, is characterized in that: the specification of described polyster fibre is 6 ~ 300d/2 ~ 100F.
3. a kind of artificial oviduct according to claim 1, is characterized in that: described fluororesin is formed by fluorine-containing acrylic acid ester emulsion drying.
4. a kind of artificial oviduct according to claim 1, is characterized in that: the weight ratio of described anti medicine and degradable polymer is 1 ~ 3:97 ~ 99.
5. a kind of artificial oviduct according to claim 1 or 4, is characterized in that: described anti medicine is chitosan or humic acids.
6. a kind of artificial oviduct according to claim 1 or 4, is characterized in that: described degradable polymer is one or more copolymers formed in polylactic acid, polycaprolactone, poly butyric ester.
7. a preparation method for artificial oviduct as claimed in claim 1, comprising:
(1) polyster fibre is woven into polyster fibre braided tube, in 140 ~ 160 DEG C of thermal finalizations;
(2) with the above-mentioned braided tube internal layer of fluorine-containing acrylic acid ester emulsion brushing, then drying has the braided tube of fluororesin layer in obtaining;
(3) be 1 ~ 3:97 ~ 99 by weight ratio be anti medicine and degradable polymer wiring solution-forming, be applied on trumpet-shaped mould, dry horn-like film, puts into two bell-mouthed ends respectively horn-like film, obtains artificial oviduct through hot pressing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201110401167.5A CN102551917B (en) | 2011-12-06 | 2011-12-06 | Artificial fallopian tube and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201110401167.5A CN102551917B (en) | 2011-12-06 | 2011-12-06 | Artificial fallopian tube and preparation method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN102551917A CN102551917A (en) | 2012-07-11 |
| CN102551917B true CN102551917B (en) | 2015-06-03 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201110401167.5A Expired - Fee Related CN102551917B (en) | 2011-12-06 | 2011-12-06 | Artificial fallopian tube and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN102551917B (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112535767A (en) * | 2019-09-20 | 2021-03-23 | 江苏启灏医疗科技有限公司 | Preparation method of fallopian tube scaffold |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN2726573Y (en) * | 2004-07-02 | 2005-09-21 | 山东省计划生育科学技术研究所 | Restorable memory alloy silicone rubber oviduct cork |
| CN1897990A (en) * | 2003-12-22 | 2007-01-17 | 株式会社I.S.T. | Medical tube and its manufacturing method |
| CN2870771Y (en) * | 2006-03-07 | 2007-02-21 | 王哲 | Utering tube interstitialis stand and holder |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3343248A1 (en) * | 1983-11-30 | 1985-06-05 | Mohamed Naim Dr.med. 3000 Hannover Saymé | Implant as substitute for a fallopian tube whose function is disturbed |
| US4574000A (en) * | 1984-08-24 | 1986-03-04 | Hunter Stephen K | Artificial fallopian tube |
| CN1158050C (en) * | 2001-02-12 | 2004-07-21 | 周星 | Artificial intracavity duct |
| CN2617333Y (en) * | 2003-04-25 | 2004-05-26 | 杜永义 | Articial multi-use implantation tube |
-
2011
- 2011-12-06 CN CN201110401167.5A patent/CN102551917B/en not_active Expired - Fee Related
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1897990A (en) * | 2003-12-22 | 2007-01-17 | 株式会社I.S.T. | Medical tube and its manufacturing method |
| CN2726573Y (en) * | 2004-07-02 | 2005-09-21 | 山东省计划生育科学技术研究所 | Restorable memory alloy silicone rubber oviduct cork |
| CN2870771Y (en) * | 2006-03-07 | 2007-02-21 | 王哲 | Utering tube interstitialis stand and holder |
Non-Patent Citations (3)
| Title |
|---|
| 甲壳胺影响变形链球菌粘附力的研究;张雅萍等;《中国微生态学杂志》;20011031;第13卷(第5期);第269页至第270页 * |
| 腐植酸铈的抑菌作用;张辉等;《中国稀土学报》;19981231;第16卷(第3期);第97页 * |
| 进口医用可吸收缝合线做支架用于输卵管子宫角植入术的体会;刘静等;《中国计划生育学杂志》;20031231;第11卷(第7期);第435页右栏倒数第2段 * |
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| Publication number | Publication date |
|---|---|
| CN102551917A (en) | 2012-07-11 |
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Granted publication date: 20150603 Termination date: 20171206 |